Anti-infection human body lubricant containing plant components as well as preparation method and application of anti-infection human body lubricant

Abstract

The invention belongs to the technical field of anti-infection human body lubricants, and particularly relates to an anti-infection human body lubricant containing plant components as well as a preparation method and application of the anti-infection human body lubricant. The anti-infection human body lubricant is composed of the following components in parts by weight: 1-3 parts of an antibacterial component; 1-4 parts of a lubricating component; 8-10 parts of a solvent component; wherein the antibacterial component is prepared by mixing procyanidine, obaculactone and lotus seed polysaccharide according to a weight part ratio of 5: (0.5-1): (0.5-1). The anti-infection human body lubricant disclosed by the invention contains plant-derived active ingredients, is high in safety, does not need a harsh chemical synthesis process, and also has anti-infection effects, such as bacteria resistance, fungus resistance and trichomonad resistance, while playing a lubricating role.

Description

Technical Field

[0001] The invention belongs to the technical field of anti-infection human body lubricants, and in particular relates to an anti-infection human body lubricant containing plant components, a preparation method and an application thereof. Background Art

[0002] Anti-infection human lubricants usually refer to vaginal lubricants, which can increase the lubrication effect and reduce skin damage. Anti-infection human lubricants can help relieve pain or discomfort during sexual intercourse, and are suitable for various situations such as sexual life, gynecological examinations, and anorectal examinations. Common anti-infection human lubricants on the market mainly include glycerin, vaseline, sodium hyaluronate, ethyl cellulose, carbomer, sodium stearate, sodium lactate and other ingredients. Some anti-infection human lubricants also include antibacterial ingredients or antiviral ingredients to avoid local infection. For example, Chinese patent CN100418541C adds nanosilver ingredients for antibacterial, Chinese patent CN115040700B adds antibacterial polymers, and Chinese patent CN1319606C adds antibacterial drugs. However, when chemical components or drugs are used for antibacterial, many pathogenic bacteria will develop drug resistance after a long time, resulting in a decrease in the antibacterial efficiency of chemical components or drugs, and the production conditions of chemical components are harsh. Therefore, other new anti-infection lubricants with low pollution are developed.

[0003] Active ingredients derived from plants are highly safe and do not require harsh chemical synthesis processes. There are also many studies in the prior art that use lubricants with active ingredients derived from plants, such as CN1091652A, CN113209163A, etc. However, the anti-infection effect of these prior arts is not obvious or even has no anti-infection effect. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides an anti-infection human lubricant containing plant ingredients, a preparation method and an application thereof. The anti-infection human lubricant can not only play a lubricating role, but also resist infection.

[0005] The object of the present invention is to provide an anti-infection human body lubricant containing plant ingredients, which is composed of the following ingredients in parts by weight:

[0006] 1 to 3 parts of antibacterial ingredients;

[0007] 1 to 4 parts of lubricating ingredients;

[0008] 8 to 10 parts of solvent component;

[0009] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.5-1:0.5-1;

[0010] The lubricating component is formed by mixing a thickener and an oily component in a weight ratio of 5:1 to 1.5;

[0011] The solvent component is an inorganic solvent;

[0012] The anti-infection includes at least anti-trichomoniasis infection.

[0013] In the inventive concept of the present invention, the antibacterial component is a mixture of proanthocyanidins, phellodendron lactone, and lotus seed polysaccharide in a weight ratio of 5:0.5-1:0.5-1. These antibacterial components are all derived from plants, have a high safety factor, can be obtained by extraction, do not need to go through harsh chemical synthesis processes, and have a stable chemical structure in the natural environment. For example, the extraction methods of proanthocyanidins include organic solvent extraction, green solvent extraction, liquid phase extraction, microwave-assisted extraction, solid phase extraction, column chromatography, etc.

[0014] During the research process of the present invention, the specific information of the antibacterial ingredients is as follows:

[0015] The CAS number of proanthocyanidins is 4852-22-6, purchased from Chengdu Lemeitian Pharmaceutical Technology Co., Ltd., the product number is DY0049, and the content of UV is ≥95%.

[0016] Phellodendron lactone, CAS No. 1180-71-8, is derived from Phellodendron, which is derived from the dried bark of the Rutaceae plant Phellodendron chinense, commonly known as Sichuan Phellodendron, and is mainly produced in Sichuan, Guizhou and other places. At present, the efficacy and function of Phellodendron chinense are mainly to clear away heat and dampness, purge fire and eliminate symptoms, and detoxify and treat sores. The medicinal properties of Phellodendron chinense are relatively bitter and cold, and it belongs to the kidney meridian and bladder meridian. Our research found that in the composition of the anti-infection human lubricant of the present invention, Phellodendron lactone can inhibit the content of proinflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8, thereby achieving antibacterial and anti-trichomonal effects.

[0017] Lotus seed polysaccharide is extracted from lotus seeds by using existing technology, such as referring to the method of Example 1 in CN108753872B or CN111607629B. It should be noted that in the specific embodiment of the present invention, the chain lotus seed polysaccharide used is extracted by referring to the method of Example 1 in CN111607629B. In the composition of the anti-infection human lubricant of the present invention, lotus seed polysaccharide can inhibit the amount of pro-inflammatory cytokines TNF-α, IL-6 and IL-8, and achieve anti-fungal, anti-bacterial and anti-trichomonal effects.

[0018] In the composition of the anti-infection human body lubricant of the present invention, the lubricating component has a lubricating effect, and the solvent component has a function of mixing the antibacterial component and the lubricating component. The viscous product texture composed of the lubricating component and the solvent component is not only convenient for the dispersion of the antibacterial component, but also helps the antibacterial component to adhere to the mucous membrane and the skin. In addition, the viscous product texture has adhesion to fungi, bacteria and trichomonas, and increases the action time of the antibacterial component with fungi, bacteria and trichomonas, thereby achieving a significant anti-infection effect.

[0019] Preferably, in the above-mentioned anti-infection human lubricant containing plant ingredients, the thickener is carbomer or hydroxyethyl cellulose, and the oily component is glycerol or propylene glycol.

[0020] Preferably, in the above-mentioned anti-infection human lubricant containing plant ingredients, the inorganic solvent is sterile deionized water or sterile physiological saline, and the sterile physiological saline is obtained by sterilizing a sodium chloride solution with a mass concentration of 9%.

[0021] Preferably, in the above-mentioned anti-infection human lubricant containing plant ingredients, the mass ratio of phellodendron lactone and lotus seed polysaccharide is 1:1.

[0022] Preferably, in the above-mentioned anti-infection human body lubricant containing plant ingredients, the antibacterial ingredient is a mixture of proanthocyanidins, phellodendron lactone, and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6;

[0023] Alternatively, the antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.7:0.7.

[0024] The above combinations of weight proportions have been verified by us to be the most effective and are the embodiments with the best anti-infection effect.

[0025] Based on the same inventive concept, the present invention also provides a method for preparing an anti-infective human lubricant containing plant ingredients, comprising: preparing an antibacterial ingredient, a lubricating ingredient and a solvent ingredient separately; then mixing and homogenizing the antibacterial ingredient, the lubricating ingredient and the solvent ingredient to obtain the anti-infective human lubricant. The preparation method is a simple mixing operation, is simple and easy to operate, and has a low production cost.

[0026] Based on the same inventive concept, the present invention also provides an application of the above-mentioned anti-infection human lubricant containing plant ingredients, wherein the anti-infection human lubricant is used for anti-bacteria, anti-fungus and anti-trichomoniasis.

[0027] Preferably, in the use of the above-mentioned anti-infection human lubricant containing plant ingredients, the bacteria are Staphylococcus aureus, non-hemolytic Streptococcus, and Gardnerella vaginalis.

[0028] Preferably, in the use of the above-mentioned anti-infection human lubricant containing plant ingredients, the fungi are Candida albicans and Candida albicans.

[0029] Based on the same inventive concept, the present invention also provides an anti-infective external preparation, comprising the anti-infective human lubricant and pharmaceutically acceptable excipients.

[0030] For example, the auxiliary material is a preservative for extending the shelf life. More specifically, the preservative is benzoic acid and its salts, sorbic acid, methyl paraben, benzalkonium bromide, etc. The amount of the preservative is 0.01% to 0.25% of the mass of the lubricant for infecting the human body.

[0031] In summary, compared with the prior art, the present invention has at least the following beneficial effects:

[0032] The anti-infection human lubricant of the present invention can not only play a lubricating role, but also resist infection, and has good anti-bacterial, anti-fungal and anti-trichomonal properties. When it plays an anti-infection effect, it can reduce the content of TNF-α, IL-1β, IL-6 and IL-8, and promote the body to play an anti-infection role. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 It is the technical roadmap of the present invention.

[0034] Figure 2 is the survival rate of Staphylococcus aureus.

[0035] Figure 3 is the survival rate of non-hemolytic streptococci.

[0036] Figure 4 is the survival rate of vaginal Gardnerella.

[0037] Figure 5 is the survival rate of Candida albicans.

[0038] Figure 6 is the survival rate of Candida albicans.

[0039] Figure 7 is the survival rate of Trichomonas.

[0040] Figure 8 is the TNF-α content.

[0041] Fig. 9 is the IL-1β content.

[0042] Fig.10 is the IL-6 content.

[0043] Fig.11 is the IL-8 content. DETAILED DESCRIPTION

[0044] In order to enable those skilled in the art to better understand and implement the technical solution of the present invention, the present invention is further described below in conjunction with specific embodiments and drawings.

[0045] In the description of the present invention, unless otherwise specified, all reagents used are commercially available and all methods used are conventional techniques in the art.

[0046] Example 1

[0047] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0048] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.5:0.5.

[0049] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0050] The solvent component is sterile water.

[0051] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0052] Example 2

[0053] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0054] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6.

[0055] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0056] The solvent component is sterile water.

[0057] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0058] Example 3

[0059] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0060] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.7:0.7.

[0061] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0062] The solvent component is sterile water.

[0063] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0064] Example 4

[0065] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0066] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.8:0.8.

[0067] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0068] The solvent component is sterile water.

[0069] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0070] Example 5

[0071] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0072] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.9:0.9.

[0073] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0074] The solvent component is sterile water.

[0075] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0076] Example 6

[0077] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0078] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:1:1.

[0079] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0080] The solvent component is sterile water.

[0081] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0082] Example 7

[0083] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0084] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.5:1.

[0085] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0086] The solvent component is sterile water.

[0087] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0088] Example 8

[0089] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0090] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:1:0.5.

[0091] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0092] The solvent component is sterile water.

[0093] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0094] Example 9

[0095] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0096] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.5:0.5.

[0097] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0098] The solvent component is sterile water.

[0099] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0100] Example 10

[0101] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0102] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6.

[0103] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0104] The solvent component is sterile water.

[0105] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0106] Embodiment 11

[0107] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0108] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.7:0.7.

[0109] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0110] The solvent component is sterile water.

[0111] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0112] Example 12

[0113] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0114] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.8:0.8.

[0115] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0116] The solvent component is sterile water.

[0117] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0118] Example 13

[0119] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0120] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.9:0.9.

[0121] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0122] The solvent component is sterile water.

[0123] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0124] Embodiment 14

[0125] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0126] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:1:1.

[0127] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0128] The solvent component is sterile water.

[0129] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0130] Embodiment 15

[0131] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0132] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.5:1.

[0133] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0134] The solvent component is sterile water.

[0135] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0136] Example 16

[0137] The invention discloses an anti-infection human body lubricant containing plant components, which is composed of the following components in parts by weight: 3 parts of antibacterial components, 4 parts of lubricating components, and 10 parts of solvent components.

[0138] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:1:0.5.

[0139] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.

[0140] The solvent component is sterile water.

[0141] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0142] Embodiment 17

[0143] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0144] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6.

[0145] The lubricating component is a mixture of hydroxyethyl cellulose and glycerin in a weight ratio of 5:1.5.

[0146] The solvent component is sterile water.

[0147] The preparation method of the anti-infection human body lubricant containing plant ingredients is as follows: respectively preparing an antibacterial component, a lubricating component and a solvent component; then mixing and homogenizing the antibacterial component, the lubricating component and the solvent component to obtain the anti-infection human body lubricant.

[0148] Embodiment 18

[0149] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0150] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6.

[0151] The lubricating component is prepared by mixing hydroxycarbomer and propylene glycol in a weight ratio of 5:1.

[0152] The solvent component is sterile water.

[0153] The preparation method of the anti-infection human lubricant containing plant ingredients is as follows: prepare the antibacterial component, the lubricating component and the solvent component respectively; then mix the lubricating component with the solvent component first, let it stand for 24 hours, then add the antibacterial component, homogenize, and obtain the anti-infection human lubricant.

[0154] Embodiment 19

[0155] An anti-infection human body lubricant containing plant ingredients is composed of the following ingredients in parts by weight: 1 part of antibacterial ingredient; 1 part of lubricating ingredient; and 8 parts of solvent ingredient.

[0156] The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6.

[0157] The lubricating component is a mixture of hydroxycarbomer and propylene glycol in a weight ratio of 5:1.5.

[0158] The solvent component is sterile water.

[0159] The preparation method of the anti-infection human lubricant containing plant ingredients is as follows: prepare the antibacterial component, the lubricating component and the solvent component respectively; then mix the lubricating component with the solvent component first, let it stand for 24 hours, then add the antibacterial component, homogenize, and obtain the anti-infection human lubricant.

[0160] In order to prove the anti-infection effect of the present invention, we conducted antibacterial test and pro-inflammatory factor test respectively.

[0161] 1. Antibacterial test

[0162] 1. Test materials: ATCC43300 Staphylococcus aureus (a type of Staphylococcus aureus), Gamma-Streptococcus (a type of non-hemolytic streptococcus), ATCC49145 Gardnerella vaginalis (a type of Gardnerella vaginalis), ATCC42265 Candida albicans (a type of Candida albicans), ATCC10231 Candida albicans (a type of Candida albicans), ATCC15946 Trichomonas saccharophila (a type of Trichomonas).

[0163] 2. Test method: The anti-infective human lubricants of Examples 1 to 19 were added to the culture medium of the above test materials, and the survival rate of the test materials was calculated after 30 minutes.

[0164] Among them, the concentration of live bacteria in the culture medium of bacterial test materials is 10 9 CFU / mL; in the culture medium of fungal test materials, the concentration of live fungi is 10 8 CFU / mL; the concentration of live strains of Trichomonas in the culture medium of Trichomonas is 10 6 Pieces / mL.

[0165] The survival rate was calculated as follows:

[0166]

[0167] 3. Experimental setup:

[0168] Single factor group 1: the antibacterial component used in the test material is proanthocyanidin, and the rest is the same as in Example 2.

[0169] Single factor group 2: The antibacterial component used in the test material is phellodendron lactone, and the rest is the same as in Example 2.

[0170] Single factor group 3: The antibacterial component used in the test material is lotus seed polysaccharide, and the rest is the same as in Example 2.

[0171] Composite factor group: the antibacterial component of the formulation of Example 2.

[0172] Blank control: no antibacterial component was added, and the rest was the same as Example 2.

[0173] Example 1 to Example 19 correspond to the anti-infection human body lubricants containing plant ingredients prepared in Examples 1 to 19. By comparing the antibacterial effects of the composite factor group and Example 2, the contribution of the lubricating component and the solvent component to the antibacterial effect can be seen. By comparing the single factor group 1 to the single factor group 3 and Example 2, the contribution of the composite antibacterial component to the antibacterial effect can be seen.

[0174] 4. Data processing: Each test group was tested three times in parallel, and the test results were averaged.

[0175] 5. Test results: The results are shown in Table 1 below. The results in Table 1 show that the antibacterial effects of Examples 1 to 19 are the best. In order to more intuitively compare the significant differences in the antibacterial effects of each group, we also plotted Figure 2 to Figure 7 , with error bars.

[0176] Table 1 Antibacterial test results

[0177]

[0178]

[0179] 2. Pro-inflammatory Factor Test

[0180] Using the HeLa cell culture model, sterile deionized water + vaginal Gardnerella + Candida albicans infection triggered HeLa cells to secrete proinflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8; in addition, after treatment with different drugs + vaginal Gardnerella + Candida albicans infection, the test results of cytokine secretion concentration are shown in Table 2. TNF-α, IL-1β, IL-6 and IL-8 were tested using their respective kits.

[0181] Among them, the settings of different drug treatments are as follows:

[0182] Single factor group 1: the antibacterial component used in the test material is proanthocyanidin, and the rest is the same as in Example 2.

[0183] Single factor group 2: The antibacterial component used in the test material is phellodendron lactone, and the rest is the same as in Example 2.

[0184] Single factor group 3: The antibacterial component used in the test material is lotus seed polysaccharide, and the rest is the same as in Example 2.

[0185] Composite factor group: the antibacterial component of the formulation of Example 2.

[0186] Blank control: no antibacterial component was added, and the rest was the same as Example 2.

[0187] Example 1 group to Example 19 group correspond to the anti-infective body lubricants containing plant ingredients prepared in the above-mentioned Example 1 to Example 19, respectively.

[0188] From the results in Table 2, it can be seen that after being treated with the anti-infective human lubricants containing plant ingredients in Examples 1 to 19 of the present invention, the pro-inflammatory factors secreted by cells were significantly reduced. Figure 8 to Figure 11 , with error bars.

[0189] Table 2 Pro-inflammatory factor test results

[0190]

[0191]

[0192] It should be noted that when the present invention involves a numerical range, it should be understood that the two endpoints of each numerical range and any value between the two endpoints can be selected. Since the steps and methods used are the same as those in the embodiments, in order to avoid redundancy, the present invention describes a preferred embodiment. Although the preferred embodiments of the present invention have been described, once those skilled in the art know the basic creative concept, they can make other changes and modifications to these embodiments, and these changes and modifications all fall within the scope of the present invention.

[0193] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. If these modifications and variations of the present invention fall within the scope of the equivalent technology of the present invention, the present invention is also intended to include these modifications and variations.

Claims

1. An anti-infection human body lubricant containing plant ingredients, characterized in that: It is composed of the following ingredients in parts by weight: 1 to 3 parts of antibacterial ingredients; 1 to 4 parts of lubricating ingredients; 8 to 10 parts of solvent component; The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.5-1:0.5-1; The lubricating component is formed by mixing a thickener and an oily component in a weight ratio of 5:1 to 1.5; The solvent component is an inorganic solvent; The anti-infection includes at least anti-trichomoniasis infection.

2. The anti-infection human body lubricant containing plant ingredients according to claim 1, characterized in that: The mass ratio of phellodendron lactone and lotus seed polysaccharide is 1:

1.

3. The anti-infection human body lubricant containing plant ingredients according to claim 2, characterized in that: The antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.6:0.6; Alternatively, the antibacterial component is prepared by mixing proanthocyanidins, phellodendron lactone and lotus seed polysaccharide in a weight ratio of 5:0.7:0.

7.

4. The anti-infection human body lubricant containing plant ingredients according to claim 1, characterized in that: The thickener is carbomer or hydroxyethyl cellulose; The oily component is glycerin or propylene glycol.

5. The method for preparing the anti-infection human body lubricant containing plant ingredients according to claim 1, characterized in that: The antibacterial component, the lubricating component and the solvent component are prepared separately; then the antibacterial component, the lubricating component and the solvent component are mixed and homogenized to obtain an anti-infection human body lubricant.

6. The use of the anti-infection human lubricant containing plant ingredients according to claim 1, characterized in that: The anti-infective personal lubricant is used to fight bacteria, fungi and trichomonas.

7. The use of the anti-infection human lubricant containing plant ingredients according to claim 6, characterized in that: The bacteria are Staphylococcus aureus, non-hemolytic Streptococcus and Gardnerella vaginalis.

8. The use of the anti-infection human lubricant containing plant ingredients according to claim 6, characterized in that: The fungi are Candida and Candida albicans.

9. An anti-infective external preparation, characterized in that: The invention comprises the anti-infective human lubricant according to claim 1 and pharmaceutically acceptable excipients.

10. The anti-infective external preparation according to claim 9, characterized in that: The auxiliary material is a preservative.

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