Human intestinal probiotic group for improving properties of Chinese herbal medicines and culture medium of human intestinal probiotic group

Abstract

The invention relates to the technical field of microbial flora, in particular to a human intestinal probiotic flora for improving the properties of Chinese herbal medicines and a culture medium thereof. According to the invention, traditional Chinese medicine extracting solutions with different proportions of sourness, sweetness, bitterness, pungency and salty and a culture medium are fermented in an ecological environment simulating a human digestive system to obtain the liquid medicine for improving the properties of Chinese herbal medicines, wherein the liquid medicine contains human intestinal probiotics. The human intestinal probiotic group capable of improving the properties of the Chinese herbal medicines can fully digest and decompose the Chinese herbal medicines and remove the peculiar smell of the Chinese herbal medicines, so that the sour and sweet taste favored by people is achieved, and the problem of bitter taste of good medicines is solved. Through simultaneous inoculation and co-fermentation, bitter taste is removed, the beverage is sour, sweet and tasty, diarrhea, nausea and vomiting after taking are reduced, and appetite is improved.

Description

Technical Field

[0001] The invention relates to the technical field of microbial flora, and in particular to a human intestinal probiotic flora and a culture medium thereof for improving the medicinal properties of Chinese herbal medicines. Background Art

[0002] Many single bacterial strains can achieve the purpose of fermentation after being domesticated and grown, but the ingredients needed by the human body need to be re-digested and decomposed by intestinal probiotics.

[0003] Chinese herbal medicines have five medicinal properties: sour, sweet, bitter, pungent, and salty, and need to be digested and decomposed by probiotics in the human intestine. However, the digestion and absorption functions of probiotics in different human intestinal tracts are different. When Chinese herbal medicines that need to be digested before they can be absorbed are taken orally, they will produce rejection reactions such as diarrhea, nausea, and vomiting. Summary of the invention

[0004] Based on the above background technology, the present invention provides a human intestinal probiotic flora and a culture medium thereof for improving the medicinal properties of Chinese herbal medicines.

[0005] A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicines, comprising the following bacterial species in percentage: 20%-70% of bacterial species A, 20%-25% of bacterial species B, and 10%-60% of bacterial species C.

[0006] Further, the following percentages of strains are included: 20% of strain A, 20% of strain B and 60% of strain C.

[0007] Further, the following percentages of strains are included: 40% of strain A, 20% of strain B and 40% of strain C.

[0008] Further, the following percentages of strains are included: 50% of strain A, 25% of strain B and 25% of strain C.

[0009] Further, the following percentages of strains are included: 60% of strain A, 20% of strain B and 20% of strain C.

[0010] Further, the following percentages of strains are included: 70% of strain A, 20% of strain B and 10% of strain C.

[0011] Furthermore, the bacterial species A is Bifidobacterium longum or Bifidobacterium breve or Bifidobacterium adolescentis or Bifidobacterium infantis, the bacterial species B is Lactobacillus casei or Lactobacillus bulgaricus or Lactobacillus delbrueckii subspecies or Lactobacillus gestell, and the bacterial species C is Lactobacillus acidophilus.

[0012] A culture medium for human intestinal probiotics for improving the medicinal properties of Chinese herbal medicines comprises the following raw materials in parts by weight: 5-15 parts of glucose, 0.5-1.5 parts of non-genetically modified soybean peptide powder, 0.5-1.5 parts of yeast powder, 0.5-1.5 parts of aspartame, 1-3 parts of yeast extract, 2-6 parts of peptone, 0.05-0.15 parts of potassium dihydrogen phosphate, 0.05-0.15 parts of dipotassium hydrogen phosphate, 0.02-0.06 parts of zinc sulfate, 0.01-0.03 parts of ferrous sulfate, 0.03-0.09 parts of magnesium sulfate and 0.001-0.003 parts of sucralose.

[0013] Beneficial effects of the present invention: The present invention obtains a medicinal liquid for improving the medicinal properties of Chinese herbal medicine by fermenting Chinese herbal medicine extracts and culture media with different proportions of sour, sweet, bitter, pungent and salty in an ecological environment that simulates the human digestive system, wherein the medicinal liquid contains a human intestinal probiotic group. The human intestinal probiotic group for improving the medicinal properties of Chinese herbal medicine of the present invention can fully digest and decompose the Chinese herbal medicine, and remove the unique smell of the Chinese herbal medicine, achieving the sour and sweet taste that people like, and solving the problem of "good medicine tastes bitter". After simultaneous inoculation and co-fermentation, the bitter taste is removed, the medicine tastes sweet and sour, and the occurrence of diarrhea, nausea and vomiting after taking the medicine is reduced, and the appetite is improved. DETAILED DESCRIPTION

[0014] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0015] A human intestinal probiotic flora and a culture medium for improving the medicinal properties of Chinese herbal medicines, comprising the following bacterial species in percentage: 20%-70% of bacterial species A, 20%-25% of bacterial species B and 10%-60% of bacterial species C.

[0016] In this embodiment, the bacterial species A is Bifidobacterium longum or Bifidobacterium breve or Bifidobacterium adolescentis or Bifidobacterium infantis, the bacterial species B is Lactobacillus casei or Lactobacillus bulgaricus or Lactobacillus delbrueckii subsp. or Lactobacillus gestell, and the bacterial species C is Lactobacillus acidophilus.

[0017] Preferably, when the ratio of sour and sweet to bitter, pungent and salty in the Chinese herbal medicine is 1:4, the percentages of strain A, strain B and strain C are 20%, 20% and 60% respectively; Preferably, when the ratio of sour and sweet to bitter, pungent and salty in the Chinese herbal medicine is 3:2, the percentages of strain A, strain B and strain C are 40%, 20% and 40% respectively; Preferably, when the ratio of sour and sweet to bitter, pungent and salty in the Chinese herbal medicine is 1:1, the percentages of strain A, strain B and strain C are 50%, 25% and 25% respectively; Preferably, when the ratio of sour and sweet to bitter, pungent and salty in the Chinese herbal medicine is 2:3, the percentages of strain A, strain B and strain C are 60%, 20% and 20% respectively; When the ratio of sour and sweet, bitter, pungent and salty in Chinese herbal medicine is 4:1, the percentages of strains A, B and C are 70%, 20% and 10% respectively.

[0018] A culture medium for human intestinal probiotics for improving the medicinal properties of Chinese herbal medicines comprises the following raw materials in parts by weight: 5-15 parts of glucose, 0.5-1.5 parts of non-genetically modified soybean peptide powder, 0.5-1.5 parts of yeast powder, 0.5-1.5 parts of aspartame, 1-3 parts of yeast extract, 2-6 parts of peptone, 0.05-0.15 parts of potassium dihydrogen phosphate, 0.05-0.15 parts of dipotassium hydrogen phosphate, 0.02-0.06 parts of zinc sulfate, 0.01-0.03 parts of ferrous sulfate, 0.03-0.09 parts of magnesium sulfate and 0.001-0.003 parts of sucralose.

[0019] Due to the high fluidity of the human intestine, after food enters the intestine through gastric enzymolysis, it stays in the duodenum and the jejunum of the small intestine for a short time, and stays in the ileum for a long time and undergoes relatively static fermentation, but it will also be fermented and excreted within a day. Therefore, although the existing intestinal probiotics are distributed in different locations, they are not mutually exclusive, but symbiotic, that is, they exert their own fission and proliferate together through symbiosis. They work together to cope with challenges in the surrounding environment, resist antibiotic treatment and immune response, and can survive under extremely harsh conditions. Therefore, in an ecological environment that mimics the human digestive system, Chinese herbal medicines are mixed with culture media, inoculated and fermented to obtain a liquid medicine that improves the medicinal properties of Chinese herbal medicines, which contains human intestinal probiotics.

[0020] After the Chinese herbal extract and the culture medium are mixed and stirred evenly, high pressure and high temperature sterilization are carried out, and then the temperature is cooled and adjusted to 36.9°C. In the present embodiment, preferably, 36.9°C is the middle value of normal human body temperature, the purpose is to strictly control the temperature and imitate the ecological environment of the human digestive system. Then inoculation and fermentation are carried out, and the inoculation and fermentation process strictly maintains the temperature range of 36.5°C-37.3°C for inoculation. At different stages of human intestinal digestion and decomposition of food, due to different food ingredients, the human immune system will kill harmful substances through regulation, and body temperature fluctuations will occur, but there is a strict range of 36.5°C-37.3°C, that is, different stages of fermentation are within the normal human body temperature range, reaching the critical value, and quickly adjusting to 36.9 degrees, and finally obtaining this microecological environment and the in vivo environment of intestinal digestion and decomposition under the condition of high consistency of the medicinal liquid of Chinese herbal medicine, which contains human intestinal probiotics.

[0021] No matter how the substances with various smells such as sour, sweet, bitter, pungent, and salty in Chinese herbal medicines are combined, they can be fully digested and decomposed at appropriate concentrations by inoculating different proportions of probiotics according to the above embodiment, and the unique smell of Chinese herbal medicines is removed, achieving the sour and sweet taste that people like, solving the problem of "good medicine tastes bitter". After simultaneous inoculation and co-fermentation, the bitterness is removed, the sweet and sour taste is delicious, the occurrence of diarrhea, nausea, and vomiting after taking is reduced, and the appetite is improved.

[0022] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for a person skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to replace some of the technical features therein by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions claimed to be protected by the present invention.

Claims

1. A human intestinal probiotic flora for improving the medicinal properties of Chinese herbal medicines, It is characterized in that The bacterial species are included in the following percentages: 20%-70% of species A, 20%-25% of species B and 10%-60% of species C.

2. A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicine as claimed in claim 1, It is characterized in that It is characterized in that The following percentages of strains are included: 20% of strain A, 20% of strain B and 60% of strain C.

3. A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicine as claimed in claim 1, It is characterized in that It is characterized in that The following percentages of strains are included: 40% strain A, 20% strain B and 40% strain C.

4. A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicine as claimed in claim 1, It is characterized in that It is characterized in that The following percentages of strains are included: 50% strain A, 25% strain B and 25% strain C.

5. A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicine as claimed in claim 1, It is characterized in that It is characterized in that The following percentages of strains are included: 60% strain A, 20% strain B and 20% strain C.

6. A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicine as claimed in claim 1, It is characterized in that It is characterized in that The following percentages of strains are included: 70% strain A, 20% strain B and 10% strain C.

7. A human intestinal probiotic flora and culture medium for improving the medicinal properties of Chinese herbal medicine according to any one of claims 1 to 6, It is characterized in that The bacterial species A is Bifidobacterium longum or Bifidobacterium breve or Bifidobacterium adolescentis or Bifidobacterium infantis, the bacterial species B is Lactobacillus casei or Lactobacillus bulgaricus or Lactobacillus delbrueckii subspecies or Lactobacillus gestell, and the bacterial species C is Lactobacillus acidophilus.

8. A culture medium for human intestinal probiotics for improving the medicinal properties of Chinese herbal medicines, It is characterized in that The invention comprises the following raw materials in parts by weight: 5-15 parts of glucose, 0.5-1.5 parts of non-genetically modified soybean peptide powder, 0.5-1.5 parts of yeast powder, 0.5-1.5 parts of aspartame, 1-3 parts of yeast extract, 2-6 parts of peptone, 0.05-0.15 parts of potassium dihydrogen phosphate, 0.05-0.15 parts of dipotassium hydrogen phosphate, 0.02-0.06 parts of zinc sulfate, 0.01-0.03 parts of ferrous sulfate, 0.03-0.09 parts of magnesium sulfate and 0.001-0.003 parts of sucralose.