Analysis mechanism and blood coagulation analyzer thereof

Abstract

The invention discloses an analysis mechanism and a blood coagulation analyzer thereof. The analysis mechanism comprises an incubation disc assembly and a reagent disc assembly, the incubation disc assembly is of a rotating disc type structure and comprises a plurality of cup positions used for containing reaction cups, and sample placing positions used for receiving the reaction cups subjected to sample dispensing and at least one dispensing reagent position used for dispensing reagents into the reaction cups are arranged in the cup positions; the reagent disc assembly is of a rotating disc type structure, is concentric with the incubation disc assembly and is used for bearing at least one required reagent container. The incubation disc assembly and the reagent disc assembly are coaxial, the action overlapping area is small, the operation risk is greatly reduced, and the operation smoothness of the mechanism is improved.

Description

Technical Field

[0001] The present invention relates to the field of biological detection technology, and in particular to an analysis mechanism and a coagulation analyzer thereof. Background Art

[0002] In the existing technical solutions, the mechanisms for cup filling, liquid separation, transportation, incubation, detection, and cup throwing are arranged linearly, and there is a certain area overlap between the moving mechanisms; for different test items, the incubation time may be different, or the type or quantity of required reagents may be different, resulting in complicated movement scheduling of the above mechanisms, and unable to guarantee continuous and stable output (report results).

[0003] Especially for equipment with higher test speeds, the instrument is more difficult to schedule because there are more liquid dispensing and rotating cup modules and more areas of overlapping module movements. When the motion scheduling is unreasonable to avoid motion risks, there are many empty cycles, which greatly affects the output of the analyzer report results. Summary of the invention

[0004] Based on this, it is necessary to propose an analysis mechanism and a coagulation analyzer thereof to address the above problems.

[0005] An analysis mechanism, comprising: an incubation disk assembly, a reagent disk assembly;

[0006] The incubation tray assembly is a turntable structure, including a plurality of cup positions for accommodating reaction cups, wherein the cup positions are provided with a sample placement position for receiving a reaction cup after the sample is dispensed, and at least one reagent dispensing position for dispensing reagents into the reaction cup;

[0007] The reagent tray assembly is a turntable structure, which is arranged concentrically with the incubation tray assembly and is used to carry at least one required reagent container.

[0008] Preferably, the plurality of cup positions for accommodating reaction cups are evenly distributed along the circumferential direction, and the number of the cup positions includes the sum of the first interval cup positions and the third interval cup positions, or the sum of the first interval cup positions, the second interval cup positions and the third interval cup positions. 。

[0009] Preferably, the first spaced cup positions are at least the quotient of the incubation time divided by the rotation period of the analysis mechanism, the second spaced cup positions are at least the quotient of the reagent time when triggered divided by the rotation period of the analysis mechanism, and the number of the third spaced cup positions is the number that can be evenly distributed on the incubation tray assembly after being combined with the number of the first spaced cup positions, or the number that can be evenly distributed on the incubation tray assembly after being combined with the number of the first spaced cup positions and the second spaced cup positions.

[0010] Preferably, the reagent disc assembly is located in the inner circle of the incubation disc assembly, or in the outer circle of the incubation disc assembly, or a part of the reagent disc assembly is located in the inner circle of the incubation disc assembly and another part is located in the outer circle of the incubation disc assembly.

[0011] A coagulation analyzer, comprising: the above-mentioned analysis mechanism and detection mechanism;

[0012] The detection mechanism is arranged around the analysis mechanism and is used to detect the transferred reaction cup.

[0013] Preferably, it also includes a sample dispensing mechanism, which is arranged at the periphery of the sample placement position of the analysis mechanism and is used to dispense the sample into the reaction cup.

[0014] Preferably, it further comprises a liquid dispensing mechanism, which is arranged around the analysis mechanism and is used to absorb a specified amount of reagent at intervals and dispense it into a reaction cup.

[0015] Preferably, the interval time is at least the product of the first interval cup position multiplied by the rotation period of the analysis mechanism, the second interval cup position multiplied by the rotation period of the analysis mechanism, and / or the product of the time from the injection of the second reagent until the reaction endpoint is determined by real-time analysis of the reaction curve.

[0016] Preferably, it also includes a reaction cup transport mechanism, which is arranged around the analysis mechanism and is respectively arranged at the sample placement position of the analysis mechanism and the periphery of at least one reagent dispensing position, and is used to transport the reaction cup that has completed sample dispensing to the sample placement position, grab the reaction cup at the reagent dispensing position for reagent injection, and transport the reaction cup to the detection mechanism.

[0017] Preferably, the detection mechanism further comprises an optical detection component and / or a magnetic bead detection component, and the optical detection component and the magnetic bead detection component are arranged around the incubation tray mechanism, and are both used to detect the transferred reaction cups.

[0018] The embodiments of the present invention have the following beneficial effects:

[0019] The incubation tray assembly and the reagent tray assembly described in the utility model are coaxial, and the overlapping area of ​​the movements is small, which greatly reduces the operation risk and improves the smoothness of the mechanism operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] in:

[0022] Figure 1 A schematic diagram of a structure of an analysis mechanism in an embodiment;

[0023] Figure 2 A schematic diagram of another form of the structure of the analysis mechanism in one embodiment;

[0024] Figure 3 A schematic diagram of a structure of an analysis mechanism for a single reagent in one embodiment;

[0025] Figure 4 A schematic diagram of a structure of a dual reagent analysis mechanism in one embodiment;

[0026] Figure 5 A schematic diagram of another structure of a dual reagent analysis mechanism in one embodiment;

[0027] Figure 6 It is a schematic diagram of the structure of the third form of the analysis mechanism for double reagents in one embodiment. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] The embodiment of the present invention provides an analysis mechanism, such as Figure 1 As shown, it includes: an incubation tray assembly 1 and a reagent tray assembly 2;

[0030] The incubation tray assembly 1 is a turntable structure, comprising a plurality of cup positions 101 for accommodating reaction cups, wherein the cup positions are provided with a sample placement position 102 for receiving a reaction cup after the sample is dispensed, and at least one reagent dispensing position 103 for dispensing reagents into the reaction cup;

[0031] The reagent tray assembly 2 is a turntable structure, which is concentrically arranged with the incubation tray assembly 1 and is used to carry at least one required reagent container;

[0032] The reagent is injected into the reaction cup in the incubation tray assembly 1 through the reagent tray assembly 2, and the incubation tray assembly 1 completes the incubation of the sample, or the mixture of the sample and the reagent. After that, the reaction cup that has completed the incubation is transported for detection to obtain the analysis result; the incubation tray assembly 1 is coaxial with the reagent tray assembly 2, and the overlapping area of ​​the movements is small, which greatly reduces the operation risk and improves the smoothness of the mechanism operation.

[0033] The incubation tray assembly 1 has a plurality of cup positions 101 for accommodating reaction cups evenly arranged along the circumferential direction. As the incubation tray assembly 1 rotates once in each cycle, after the rotation stops, a cup position 101 is advanced on the incubation tray assembly 1, but the sample placement position 102 and the reagent dispensing position 103 remain fixed and always correspond to the cup position 101 at that position.

[0034] The reagent disk assembly 2 is located in the inner circle of the incubation disk assembly, or in the outer circle of the incubation disk assembly, or a part of the reagent disk assembly is located in the inner circle of the incubation disk assembly and the other part is located in the outer circle of the incubation disk assembly.

[0035] Exemplarily, the reagent disk assembly 2 includes an inner disk 201 and / or an outer disk 202, the inner disk 201 is arranged on the inner circle of the outer disk 202, and the outer disk 202 is arranged on the inner circle of the incubation disk assembly 1. Alternatively, the inner disk 201 and the outer disk 202 are respectively arranged on the inner circle and outer circle of the incubation disk assembly 1.

[0036] The inner disk 201 and / or the outer disk 202 are coaxially arranged with the incubation disk assembly 1 and rotate synchronously or independently.

[0037] Specifically, for a single reagent, the inner disk 201 can be used as a reagent storage disk. During use, according to the research and development design requirements, the inner disk 201 can rotate or remain stationary;

[0038] In one embodiment, the inner disk 201 is stationary, which makes it easier to design the position of the reagent dispensing device and simplifies the control logic of the reagent dispensing device.

[0039] When a single reagent is used, the outer disc 202 can be used as a reagent containing disc. During use, according to the research and development design requirements, the outer disc 202 can rotate or remain stationary.

[0040] In one embodiment, the outer disk 202 is stationary, which makes it easier to design the position of the reagent dispensing device and simplify the control logic of the reagent dispensing device. In addition, the outer disk 202 is closer to the reagent dispensing device arranged on the periphery than the inner disk 201, shortening the action path of the reagent dispensing device to absorb and dispense the reagent.

[0041] When using two reagents, the inner disk 201 can be used as a reagent containing disk for the first reagent, and the outer disk 202 can be used as a reagent containing disk for the second reagent, or the outer disk 202 can be used as a reagent containing disk for the first reagent, and the inner disk 201 can be used as a reagent containing disk for the second reagent; during use, according to the needs of research and development and design, the inner disk 201 and the outer disk 202 rotate synchronously, or the inner disk 201 and the outer disk 202 rotate independently; by changing different rotation modes, it is easy to match the corresponding scheduling management of the reagent dispensing device and reduce the scheduling difficulty.

[0042] In one embodiment, the ratio between the rotation speed of the inner disk 201 and the rotation speed of the outer disk 202 is equal to the ratio between the diameter of the inner disk 201 and the diameter of the outer disk 202, so that the inner disk 201 and the outer disk 202 can rotate synchronously, realizing the linkage setting of the inner disk 201 and the outer disk 202 to meet the scheduling requirements of the reagent dispensing device.

[0043] In another embodiment, the outer disk 202 rotates counterclockwise at one speed, and the inner disk 201 rotates clockwise at another speed. Alternatively, the inner disk 201 and the outer disk 202 rotate in the same direction to achieve independent rotation of the inner disk 201 and the outer disk 202 to meet the scheduling requirements of the reagent dispensing device.

[0044] For single reagent, such as Figure 1 As shown, one reagent dispensing position 103 is provided, and the number of cup positions of the incubation tray assembly 1 includes the sum of the first interval cup positions and the third interval cup positions.

[0045] On the one hand, by separately changing the first interval cup position and / or the third interval cup position to improve the detection speed, it is easier to achieve high-speed output, reducing the difficulty of developing a high-speed analyzer; on the other hand, by solidifying the time of reagent injection and cup throwing process through the sum of the first interval cup position and the third interval cup position, the difficulty of subsequent scheduling is reduced, making it easier to obtain continuous and stable output.

[0046] The first spaced cup positions are cup positions spaced between the sample placement position 102 and the reagent dispensing position 103 in the counterclockwise direction, and the third spaced cup positions are cup positions spaced between the reagent dispensing position 103 and the sample placement position 102 in the counterclockwise direction.

[0047] The first interval cup position is at least the quotient of the incubation time divided by the rotation period of the analysis mechanism, which determines the minimum value of the first interval cup, thereby increasing the number of cup positions 101 based on the minimum value, that is, expanding the cup positions 101 to meet a larger number of analyses and achieve speed improvement.

[0048] For example, there are m cup positions spaced between the sample placement position 102 and the reagent dispensing position 103 in the counterclockwise direction, and the incubation tray assembly 1 needs to rotate m cycles, each rotation cycle is t seconds, and the incubation time after the sample is dispensed from the sample placement position 102 is t1, then the first interval cup positions are at least m=t1 / t;

[0049] If t1=360 seconds and t=15 seconds, then the number of first interval cup positions is at least m=360 / 15=24.

[0050] The number of the third spaced cup positions can be evenly distributed on the incubation tray assembly 1 after being combined with the number of the first spaced cup positions.

[0051] That is to say, if the number of cup positions in the first interval is at least 24, then according to the interval layout of the 24 cup positions 101, 9 cup positions 101 are needed to form a circle, and the number of cup positions in the third interval is 9.

[0052] High-speed output can be achieved by adjusting the number of cup positions in the first interval.

[0053] For double reagents, such as Figure 2 As shown, two reagent dispensing positions 103 are provided, namely a first reagent dispensing position 1031 and a second reagent dispensing position 1032 , and the number of cup positions of the incubation tray assembly 1 includes the sum of the first interval cup position, the second interval cup position, and the third interval cup position.

[0054] On the one hand, by individually changing the first spacing cup position, the second spacing cup position and / or the third spacing cup position to improve the detection speed, it is easier to achieve high-speed output, reducing the difficulty of developing a high-speed analyzer; on the other hand, by solidifying the time of the first reagent injection, the second reagent injection and the cup throwing process through the sum of the first spacing cup position, the second spacing cup position and the third spacing cup position, it is reduced The difficulty of subsequent scheduling is convenient for obtaining continuous and stable output.

[0055] The first interval cup position is the cup position 101 interval between the sample placement position 102 and the first dispensing reagent position 1031 in the counterclockwise direction, the second interval cup position is the cup position 101 interval between the first dispensing reagent position 1031 and the second dispensing reagent position 1032 in the counterclockwise direction, and the third interval cup position is the cup position 101 interval between the second dispensing reagent position 1032 and the sample placement position 102 in the counterclockwise direction.

[0056] The first interval cup position is at least the quotient of the incubation time divided by the rotation period of the analysis mechanism, which determines the minimum value of the first interval cup, thereby increasing the number of cup positions 101 based on the minimum value, that is, expanding the cup positions 101 to meet a larger number of analyses and achieve speed improvement.

[0057] For example, if there are m cup positions spaced between the sample placement position 102 and the first reagent dispensing position 1031 in the counterclockwise direction, the incubation tray assembly 1 needs to rotate m cycles, each rotation cycle is t seconds, and the incubation time from the sample placement position 102 to the first reagent dispensing is t1, then the first interval cup positions are at least m=t1 / t;

[0058] If t1=90 seconds and t=15 seconds, then the number of first interval cup positions is at least m=90 / 15=6.

[0059] There are k cup positions spaced between the first reagent dispensing position 1031 and the second reagent dispensing position 1032 in the counterclockwise direction, so the incubation tray assembly 1 needs to rotate k cycles, each rotation cycle is t seconds, and the incubation time from the first reagent dispensing position 1031 to the second reagent dispensing is t2, so the second interval cup positions are at least k=t2 / t;

[0060] If t2=180 seconds and t=15 seconds, then the number of second interval cup positions is at least k=180 / 15=12.

[0061] The number of the third spaced cup positions can be evenly distributed on the incubation tray assembly 1 after being combined with the number of the first spaced cup positions and the second spaced cup positions.

[0062] That is to say, if the number of cup positions in the first interval is at least 6 and the number of cup positions in the second interval is at least 12, then according to the interval layout of 18 cup positions 101, 8 cup positions 101 are needed to form a circle, and the number of cup positions in the third interval is 8.

[0063] If the number of cup positions of the incubation tray assembly 1 is set according to the above embodiment, 3600 / 15=240 results of the seven coagulation tests can be continuously produced every hour.

[0064] The embodiment of the present invention also provides a coagulation analyzer, such as Figure 3 , 4 As shown, including analysis agency, detection agency 3;

[0065] The detection mechanism 3 is arranged around the analysis mechanism and is used to detect the transferred reaction cup.

[0066] The detection mechanism 3 is used to detect the reaction container placed in the detection hole, and determine the reaction endpoint by real-time analysis of the reaction curve. Once the reaction endpoint is found, the test can be terminated and the reaction cup can be discarded, which reduces the occupancy time of the cup position and is conducive to obtaining a higher speed output with fewer cup positions.

[0067] The analysis mechanism is as described in the above embodiment and will not be elaborated here.

[0068] Furthermore, it also includes a sample dividing mechanism 4, which is arranged at the periphery of the sample placement position of the analysis mechanism and is used to divide the sample into the reaction cup.

[0069] The sample sorting mechanism 4 is used to sequentially send the sample rack carrying the sample containers in the loading area to the barcode scanning position, the sample suction position, the unloading area, etc., and run to the sampling position to realize the scheduling of the sample containers;

[0070] Furthermore, it also includes a cup supply component 5 arranged at the periphery of the sample placement position of the analysis mechanism;

[0071] The cup supply assembly 5 is used to sort the disordered reaction cups and then select the reaction cups, and send them to the scheduling plate to wait for the sample sorting mechanism 4 to sort the samples.

[0072] Furthermore, it also includes a liquid dispensing mechanism 6, which is arranged around the analysis mechanism and is respectively arranged at the periphery of at least one reagent dispensing position 103 of the analysis mechanism, for sucking a specified amount of reagent at intervals and dispensing it into the reaction cup.

[0073] The present invention has a unified time interval from sample addition to reagent addition, but a different time interval from adding a trigger reagent to start a reaction to completing detection. The reaction endpoint is determined by real-time analysis of the reaction curve. Once the reaction endpoint is found, the test can be terminated and the measurement result reported, which helps to shorten the time required for outputting the report. The reaction cup that has completed the test is transferred to the cup throwing position for cup throwing. By solidifying the sample addition, liquid separation, and cup throwing process, the scheduling difficulty is simplified, making it easier to obtain continuous and stable output.

[0074] For single reagent, such as Figure 3 As shown, the liquid dispensing mechanism 6 includes a sample liquid dispensing component 601 and a second reagent liquid dispensing component 603. The sample liquid dispensing component 601 is arranged between the sample dispensing mechanism 4 and the cup supply component 5, and is used to absorb a specified amount of sample or first absorb a certain amount of diluent and then absorb a specified amount of sample and dispense it into the reaction cup of the scheduling disk of the cup supply component 5; the second reagent liquid dispensing component 603 is arranged at the periphery of the reagent dispensing position 103, and is used to absorb a specified amount of reagent from the reagent disk component 2 and dispense it into the reaction cup on the incubation disk component 1;

[0075] For double reagents, such as Figure 4As shown, the dispensing mechanism 6 includes a sample dispensing component 601, a first reagent dispensing component 602, and a second reagent dispensing component 603. The sample dispensing component 601 is arranged between the sample dispensing mechanism 4 and the cup supply component 5, and is used to absorb a specified amount of sample or first absorb a certain amount of diluent and then absorb a specified amount of sample and dispense it into the reaction cup of the scheduling disk of the cup supply component 5; the first reagent dispensing component 602 is arranged on the periphery of the first dispensing reagent position 1031, and is used to absorb a specified amount of the first reagent from the reagent disk component 2 and dispense it into the reaction cup on the incubation disk component 1; the second reagent dispensing component 603 is arranged on the periphery of the second dispensing reagent position 1032, and is used to absorb a specified amount of the second reagent from the reagent disk component 2 and dispense it into the reaction cup on the incubation disk component 1.

[0076] The interval time from sample addition to reagent addition of the liquid dispensing mechanism 6 is unified, which simplifies the scheduling difficulty and facilitates obtaining continuous and stable output.

[0077] For single reagent and double reagent, the interval time of adding samples is unified, which is the rotation cycle of the analysis mechanism, that is, every time the analysis mechanism rotates one cycle, a specified amount of sample is sucked and dispensed into the reaction cup of the scheduling tray of the cup supply assembly 5.

[0078] Exemplarily, each rotation cycle is t seconds, t=15, then a specified amount of sample is drawn every 15 seconds and dispensed into the reaction cups on the scheduling tray of the cup supply assembly 5 .

[0079] For single reagent, such as Figure 3 As shown, the interval time from the sample placement position 102 to the reagent placement position 103 is m*t seconds, where m is the first interval cup position and t is the rotation period of the analysis mechanism;

[0080] Exemplarily, m=6, t=15, the interval time from the sample placement position 102 to the reagent injection position 103 is 6*15, that is, 90 seconds, that is, the reagent is injected at least once every 90 seconds.

[0081] For double reagents, such as Figure 4 As shown, the interval time from the time when the sample is dispensed into the reaction cup from the sample placement position 102 to the time when the first reagent is injected into the first reagent dispensing position 1031 is m*t seconds, wherein m is the first interval cup position and t is the rotation period of the analysis mechanism; the interval time from the time when the first reagent is dispensed into the first reagent dispensing position 1031 to the time when the second reagent is injected into the second reagent dispensing position 1032 is k*t seconds; and the interval time from the time when the second reagent is dispensed into the second reagent dispensing position 1032 to the time when the cup is thrown into the throwing position 105 is n*t seconds.

[0082] Exemplarily, m=6, k=12, t=15, the interval time from the time the sample is dispensed into the reaction cup from the sample placement position 102 to the time the first reagent is injected into the first reagent dispensing position 1031 is 6*18, i.e., 90 seconds; the interval time from the time the first reagent is dispensed into the first reagent dispensing position 1031 to the time the second reagent is injected into the second reagent dispensing position 1032 is 12*15, i.e., 180 seconds.

[0083] Furthermore, it also includes a reaction cup transport mechanism 7, which is arranged around the analysis mechanism and is respectively arranged at the sample placement position 102 of the analysis mechanism and the periphery of at least one dispensing reagent position 103, and is used to transport the reaction cup after sample dispensing to the sample placement position 102, and grab the reaction cup at the dispensing reagent position 103 for injecting reagent.

[0084] For single reagent, such as Figure 3 As shown, the reaction cup transport mechanism 7 is used to dispatch the reaction cup inside the coagulation analyzer, and includes a first grabbing hand 701 and a third grabbing hand 703;

[0085] The first grabber 701 grabs the reaction cup after sample dispensing from the sampling position of the scheduling tray of the cup supply assembly 5 to the sample placement position 102 of the incubation tray assembly 1;

[0086] The third gripper 703 grabs the reaction cup that has completed incubation from the reagent dispensing position 103 of the incubation tray assembly 1, shakes it evenly after the reagent is injected into the liquid dispensing mechanism 6, and transfers it to the detection hole of the detection mechanism 3; grabs the reaction cup that has completed detection from the detection hole of the detection mechanism 3 and transfers it to the cup throwing port for disposal.

[0087] For double reagents, such as Figure 4 As shown, the reaction cup transport mechanism 7 is used to dispatch the reaction cup inside the coagulation analyzer, and includes a first grabbing hand 701, a second grabbing hand 702, and a third grabbing hand 703;

[0088] The first grabber 701 grabs the reaction cup after sample dispensing from the sampling position of the scheduling tray of the cup supply assembly 5 to the sample placement position 102 of the incubation tray assembly 1;

[0089] The second gripper 702 grabs the reaction cup that has completed incubation from the first reagent dispensing position 1031 of the incubation tray assembly 1, shakes it evenly after the first reagent is injected into the liquid dispensing mechanism 6, and puts it back into the first reagent dispensing position 1031 of the incubation tray assembly 1;

[0090] The third gripper 703 grabs the reaction cup that has completed incubation from the second reagent dispensing position 1032 of the incubation tray assembly 1, shakes it evenly after the second reagent is injected into the liquid dispensing mechanism 6, and transports it to the detection hole of the detection mechanism 3; grabs the reaction cup that has completed detection from the detection hole transported to the detection mechanism 3 and transfers it to the cup throwing port for disposal.

[0091] Furthermore, the detection mechanism 3 includes an optical detection component 301 , and the optical detection component 301 detects the reaction cup transferred by the third gripper 703 .

[0092] like Figure 5 As shown, the sample detection component 3 further includes a magnetic bead detection component 302 , and the magnetic bead detection component 302 detects the magnetic bead cup transferred to by the third gripper 703 .

[0093] The second reagent dispensing assembly 603 injects the sample into the second reagent dispensing position 1032 located on the incubation tray assembly 1 and washes it in the washing tank;

[0094] The third gripper 703 also grabs the magnetic bead cup from the second reagent dispensing position 1032 of the incubation disk assembly 1 to the magnetic bead method detection assembly 302 for incubation. After the magnetic bead method detection assembly 302 completes the incubation, the third gripper 703 grabs the magnetic bead cup from the magnetic bead method detection assembly 302 and transfers it to the top of the second reagent dispensing position 1032. The second reagent dispensing assembly 603 absorbs the first reagent from the reagent disk assembly 2 and moves to the second reagent dispensing position 1032 for dispensing. After the dispensing is completed, the second reagent dispensing assembly 603 is cleaned in the cleaning tank, and the third gripper 703 transfers the magnetic bead cup to the detection hole of the magnetic bead method detection assembly 302 for incubation.

[0095] The third gripper 703 grabs the magnetic bead cup from the magnetic bead cup supply rack and transfers it to the second reagent dispensing position 1032. The second reagent dispensing component 603 dispenses the sample. After the dispensing is completed, R2 goes to the cleaning tank for cleaning. The third gripper 703 transfers the magnetic bead cup to the detection hole of the magnetic bead detection component 302 for incubation.

[0096] After the sample incubation is completed, the third gripper 703 grabs the magnetic bead cup from the magnetic bead detection component 302 and transports it to the top of the second reagent dispensing position 1032, the second reagent dispensing component 603 absorbs the second reagent from the reagent disk component 2, and moves to the second reagent dispensing position 1032 for dispensing, after the dispensing is completed, the second reagent dispensing component 603 goes to the cleaning tank for cleaning, and the third gripper 703 transports the magnetic bead cup to the detection hole of the magnetic bead detection component 302 for incubation;

[0097] After the incubation is completed, the third gripper 703 grabs the magnetic bead cup from the magnetic bead detection component 302 and transports it to the top of the second dispensing reagent position 1032, the second reagent dispensing component 603 absorbs the R2 reagent from the inner circle of the reagent disk, and moves to the second dispensing reagent position 1032 for dispensing. After the dispensing is completed, the second reagent dispensing component 603 goes to the cleaning pool for cleaning, and the third gripper 703 transports the magnetic bead cup to the detection hole of the magnetic bead detection component 302 to start the detection; after the detection is completed, the third gripper 703 grabs the magnetic bead cup and transfers it to the cup mouth for throwing.

[0098] Furthermore, if Figure 6 As shown, the present invention facilitates speed improvement by increasing the number of modules. For example, to achieve an output of 600 per hour, the cycle time is 3600 / 600=6 seconds, the incubation time after sample dispensing is 90s, and the interval between the sample placement position 102 and the first dispensing reagent position 1031 is adjusted to m=90 / 6=15. The incubation time after the first reagent is dispensed is 180s, and the interval between the first dispensing reagent position 1031 and the second dispensing reagent position 1032 is adjusted to n=180 / 6=30. The detection time after the second reagent is dispensed is 210s, and the interval between the second dispensing reagent position 1032 and the cup throwing position 105 is adjusted to p=210 / 6=35. If a more efficient cleaning method is adopted for the liquid dispensing mechanism 6, the number does not increase. If a conventional cleaning method is adopted, one sample liquid dispensing component 601 can be added, that is, two sample liquid dispensing components 601, and the two sample liquid dispensing components 601 are used alternately to ensure sufficient cleaning; one first reagent liquid dispensing component 602 is added, that is, two first reagent liquid dispensing components 602, and the two first reagent liquid dispensing components 602 are used alternately to ensure sufficient cleaning; one second reagent liquid dispensing component 603 is added, that is, two second reagent liquid dispensing components 603, and the two second reagent liquid dispensing components 603 are used alternately to ensure sufficient cleaning.

[0099] A fourth gripper 704 may also be added to grab the reaction cup after detection from the detection mechanism 3 and transfer it to the cup throwing port; the third gripper 703 does not perform the cup throwing action.

[0100] The two first reagent dispensing components 602 are arranged in an axisymmetric manner along the central axis of the first reagent dispensing position 1031 and the second gripper 702 , and the action radius of each first reagent dispensing component 602 is tangent to the central axis.

[0101] The two second reagent dispensing components 603 are arranged in an axisymmetric manner along the central axis of the second reagent dispensing position 1032 , and the action radius of each second reagent dispensing component 603 is tangent to the central axis.

[0102] The present invention solidifies the sample adding, reagent adding, and cup throwing action cycles, and unifies the time interval and rhythm from sample adding to reagent adding for single-reagent and double-reagent projects, thereby simplifying the scheduling difficulty and fully exerting the operating efficiency of each mechanism to facilitate obtaining continuous and stable output.

[0103] The above disclosure is only the preferred embodiment of the present invention, which certainly cannot be used to limit the scope of the present invention. Therefore, equivalent changes made according to the claims of the present invention are still within the scope of the present invention.

Claims

1. An analysis mechanism, characterized in that: include: Incubation tray assembly, reagent tray assembly; The incubation tray assembly is a turntable structure, including a plurality of cup positions for accommodating reaction cups, wherein the cup positions are provided with a sample placement position for receiving a reaction cup after the sample is dispensed, and at least one reagent dispensing position for dispensing reagents into the reaction cup; The reagent tray assembly is a turntable structure, which is arranged concentrically with the incubation tray assembly and is used to carry at least one required reagent container.

2. The analysis mechanism according to claim 1, characterized in that: The plurality of cup positions for accommodating reaction cups are evenly distributed along the circumferential direction, and the number of the cup positions includes the sum of the first interval cup positions and the third interval cup positions, or the sum of the first interval cup positions, the second interval cup positions and the third interval cup positions. 。 3. The analysis mechanism according to claim 2, characterized in that: The number of the first spaced cup positions is at least the quotient of the incubation time divided by the rotation period of the analysis mechanism, the number of the second spaced cup positions is at least the quotient of the reagent time when triggered divided by the rotation period of the analysis mechanism, and the number of the third spaced cup positions is the number that can be evenly distributed on the incubation tray assembly after being combined with the number of the first spaced cup positions, or the number that can be evenly distributed on the incubation tray assembly after being combined with the number of the first spaced cup positions and the second spaced cup positions.

4. The analysis mechanism according to any one of claims 1 to 3, characterized in that: The reagent disc assembly is located in the inner circle of the incubation disc assembly, or in the outer circle of the incubation disc assembly, or a part of the reagent disc assembly is located in the inner circle of the incubation disc assembly and the other part is located in the outer circle of the incubation disc assembly.

5. A coagulation analyzer, characterized in that: include: The analysis mechanism or detection mechanism as described in any one of claims 1 to 4; The detection mechanism is arranged around the analysis mechanism and is used to detect the transferred reaction cup.

6. The coagulation analyzer according to claim 5, characterized in that: It also includes a sample dispensing mechanism, which is arranged at the periphery of the sample placement position of the analysis mechanism and is used for dispensing the sample into the reaction cup.

7. The coagulation analyzer according to claim 5, characterized in that: The device also includes a liquid dispensing mechanism, which is arranged around the analysis mechanism and is used to absorb a specified amount of reagent at intervals and dispense it into a reaction cup.

8. The coagulation analyzer according to claim 7, characterized in that: The interval time is at least the product of the first interval cup position multiplied by the rotation period of the analysis mechanism, the second interval cup position multiplied by the rotation period of the analysis mechanism, and / or the product of the time from the injection of the second reagent to the time when the reaction endpoint is reached as determined by real-time analysis of the reaction curve.

9. The coagulation analyzer according to claim 5, characterized in that: It also includes a reaction cup transport mechanism, which is arranged around the analysis mechanism and is respectively arranged at the sample placement position of the analysis mechanism and the periphery of at least one reagent dispensing position, and is used to transport the reaction cup that has completed sample dispensing to the sample placement position, grab the reaction cup at the reagent dispensing position for reagent injection, and transport the reaction cup to the detection mechanism.

10. The blood coagulation analyzer according to claim 5, characterized in that: The detection mechanism further comprises an optical detection component and / or a magnetic bead detection component. The optical detection component and the magnetic bead detection component are arranged around the incubation tray mechanism and are both used to detect the transferred reaction cups.

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