Buccal substance and preparation method thereof
By using 0.2% to 1% gorsepine and other auxiliary components in the oral content, a powdered oral content was prepared, which solved the high cost and adverse reactions of tobacco oral content in the prior art. The problem has achieved effective relief of smoking addiction and improved user experience.
Patent Information
- Application Number
- CN202411219113.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-30
- Publication Date
- 2024-12-24
AI Technical Summary
The existing oral contents used for quitting tobacco have problems such as high use cost, which can cause adverse reactions such as pain, nausea and vomiting.
A oral content containing gorserine is 0.2% to 1%, combined with sweeteners, fillers, preservatives, antioxidants, fragrances and coolants, by mixing Prepare by stirring to form a powdery oral content to relieve smoking addiction.
By selectively acting on the nicotine-dependent nicotine receptor in the human brain, the symptoms of nicotine withdrawal are reduced, the pain of injection-like oral ingredients and the poor taste of oral lozenges are avoided, and low-cost, no nausea and vomiting are achieved withdrawal effect.
Smart Images
Figure CN119174761A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of oral contraceptives, and more specifically, to an oral contraceptive and a preparation method thereof. Background Art
[0002] As the number of people who smoke tobacco increases, the demand for quitting tobacco is also increasing. The existing oral substances for quitting tobacco or replacing tobacco include two types, one of which is an injection-type oral substance and the other is a lozenge-type oral substance.
[0003] When using injectable lozenges, users need to be in professional places (such as medical clinics) or use professional equipment (such as syringes), which causes users to suffer physical pain, affects the user experience, and increases the cost of quitting tobacco. Lozenges usually have a poor taste, making it difficult for users to use them continuously, and are also prone to causing adverse reactions such as nausea and vomiting.
[0004] In summary, the existing oral substances for quitting tobacco use have the problems of high cost of use and causing adverse reactions such as pain, nausea and vomiting. Summary of the invention
[0005] The technical problem to be solved by the embodiments of the present application is that the existing oral substances used for quitting smoking have the problems of high cost of use and causing adverse reactions such as pain, nausea and vomiting.
[0006] In order to solve the above technical problems, the embodiment of the present application adopts the following solution:
[0007] A buccal substance, the component of which includes cytisine.
[0008] Furthermore, in the components of the oral congee, the content of cytisine is 0.2% to 1%.
[0009] Furthermore, the oral substance also includes at least one of a sweetener, a filler, a preservative, an antioxidant, a flavoring agent, and a cooling agent.
[0010] Further, the sweetener includes at least one of mannitol, glucose, xylitol, sorbitol, sucralose, neotame and powdered sugar; and / or,
[0011] The flavoring agent includes at least one of a liquid flavor and a microcapsule flavor; and / or,
[0012] The cooling agent comprises at least one of WS-23, menthol and borneol; and / or,
[0013] The filler comprises at least one of microcrystalline cellulose, ethyl cellulose and hydroxyethyl cellulose; and / or,
[0014] The preservative includes at least one of benzoic acid and its salts, sorbic acid and its salts, parabens, calcium propionate, sodium lactate and sodium diacetate; and / or,
[0015] The antioxidant includes at least one of vitamin E, ascorbic acid, tea polyphenols and tocopherol.
[0016] Furthermore, the components of the oral substance include a sweetener, and the content of the sweetener is 1% to 5%; and / or,
[0017] The components of the oral congee include a flavoring agent, wherein the content of the flavoring agent is 5% to 15%; and / or,
[0018] The components of the oral substance include a cooling agent, wherein the content of the cooling agent is 1% to 5%; and / or,
[0019] The components of the oral concoction include a filler, and the content of the filler is 10% to 90%; and / or,
[0020] The components of the oral concoction include a preservative, and the content of the preservative is 1% to 5%; and / or,
[0021] The components of the oral concoction include an antioxidant, and the content of the antioxidant is 0.5% to 2%.
[0022] Furthermore, the components of the oral congee include cytisine, microcrystalline cellulose, glucose, WS-23, sorbic acid, vitamin E and microcapsule flavor.
[0023] Further, the content of cytisine is 0.8%, the content of microcrystalline cellulose is 81.2%, the content of glucose is 3%, the content of cooling agent is 2%, the content of microcapsule flavor is 10%, the content of vitamin E is 1%, and the content of sorbic acid is 2%; and / or,
[0024] The oral substance is in powder form.
[0025] Accordingly, the present application also provides a method for preparing a lozenge, the method comprising the following steps:
[0026] Provide prefabricated materials and cytisine;
[0027] The prefabricated material and cytisine are mixed and stirred to form a lozenge.
[0028] Furthermore, the step of providing the prefabricated material and cytisine comprises the following steps:
[0029] At least one of a sweetener, a filler, a preservative, an antioxidant, a flavoring agent and a cooling agent is selected as the prefabricated material.
[0030] Further, the sweetener includes at least one of mannitol, glucose, xylitol, sorbitol, sucralose, neotame and powdered sugar; and / or,
[0031] The flavoring agent includes at least one of a liquid flavor and a microcapsule flavor; and / or,
[0032] The cooling agent comprises at least one of WS-23, menthol and borneol; and / or,
[0033] The filler comprises at least one of microcrystalline cellulose, ethyl cellulose and hydroxyethyl cellulose; and / or,
[0034] The preservative includes at least one of benzoic acid and its salts, sorbic acid and its salts, parabens, calcium propionate, sodium lactate and sodium diacetate; and / or,
[0035] The antioxidant comprises at least one of vitamin E, ascorbic acid, tea polyphenols and tocopherol; and / or,
[0036] The content of cytisine is 0.2% to 1%; and / or,
[0037] The components of the prefabricated material include a sweetener, and the content of the sweetener is 1% to 5%; and / or,
[0038] The components of the prefabricated material include a flavoring agent, the content of the flavoring agent is 5% to 15%; and / or,
[0039] The components of the prefabricated material include a cooling agent, and the content of the cooling agent is 1% to 5%; and / or,
[0040] The components of the prefabricated material include a filler, and the content of the filler is 10% to 90%; and / or,
[0041] The components of the prefabricated material include a preservative, the content of the preservative is 1% to 5%; and / or,
[0042] The components of the prefabricated material include an antioxidant, and the content of the antioxidant is 0.5% to 2%.
[0043] Compared with the prior art, the embodiments of the present application have the following beneficial effects:
[0044] Since cytisine can selectively act on the nicotinic receptors in the human brain that regulate nicotine dependence, the purpose of reducing nicotine withdrawal symptoms is achieved. The oral substance prepared in the embodiment of the present application contains cytisine, so when the user takes the oral substance, the cytisine component can relieve the addiction to smoking, thereby achieving the effect of quitting tobacco. BRIEF DESCRIPTION OF THE DRAWINGS
[0045] In order to more clearly illustrate the solutions in the present application or the prior art, a brief introduction is given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0046] Figure 1 It is a flow chart of the method for preparing the oral congee according to the embodiment of the present application. DETAILED DESCRIPTION
[0047] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application. In addition, it should be understood that the specific implementation methods described herein are only used to illustrate and explain the present application, and are not used to limit the present application.
[0048] In this application, unless otherwise stated, directional words such as "upper" and "lower" generally refer to the upper and lower parts of the device in actual use or working state, specifically the drawing direction in the accompanying drawings; while "inner" and "outer" refer to the outline of the device. In addition, in the description of this application, the term "including" means "including but not limited to". The terms first, second, third, etc. are used only as labels and do not impose numerical requirements or establish an order.
[0049] In this application, "and / or" describes the association relationship of associated objects, indicating that there may be three relationships. For example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone. A and B can be singular or plural.
[0050] In the present application, "at least one" means one or more, and "plurality" means two or more. "At least one", "at least one of the following" or similar expressions refer to any combination of these items, including any combination of single items or plural items. For example, "at least one of a, b, or c", or "at least one of a, b, and c" can all mean: a, b, c, ab (i.e., a and b), ac, bc, or abc, where a, b, c can be single or multiple, respectively.
[0051] Various embodiments of the present application may be presented in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be understood as a rigid limitation on the scope of the present application; therefore, the range description should be considered to have specifically disclosed all possible sub-ranges and single numerical values within the range. For example, the range description from 1 to 6 should be considered to have specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5 and 6, which apply regardless of the range. In addition, whenever a numerical range is indicated herein, it is meant to include any cited number (fractional or integer) within the indicated range.
[0052] In order to solve the above problems, an embodiment of the present application provides a mouthful, the components of which include cytisine.
[0053] In this embodiment, cytisine is a quinolizidine alkaloid mainly found in the seeds of the genus genus of the leguminous family, which has a high binding affinity with the nicotine acetylcholine receptor. Therefore, it can selectively act on the nicotinic receptors in the human brain that regulate nicotine dependence, thereby achieving the purpose of reducing nicotine withdrawal symptoms and thus alleviating the user's urge to smoke. The oral substance of the embodiment of the present application contains cytisine, so when the user takes the oral substance, the cytisine component therein can be used to relieve the addiction to smoking, thereby achieving the effect of quitting tobacco.
[0054] The method for taking the oral substance of the embodiment of the present application includes: placing the oral substance between the lips and gums, and absorbing cytisine by the oral mucosa after the oral cavity naturally secretes saliva to decompose the oral substance. In the process of using the oral substance, because cytisine itself has no odor and will not irritate the human body within a suitable content range, the user will not feel vomiting discomfort during the process of taking the open lozenge. At the same time, compared to the injection method, the oral substance of the embodiment of the present application does not need to pierce the skin, and does not require additional cost. In summary, the oral substance of the embodiment itself has low cost of use and does not cause adverse reactions such as pain, nausea and vomiting.
[0055] It should be understood that the oral contraceptives of the embodiments of the present application can eventually be in various structures such as powder, sheet, and soft candy. Among them, when the oral contraceptive is in powder form, it can be sealed in bags, with the content of the oral contraceptive in each bag being 0.35 g, and the bag size being 30 mm long and 12 mm wide. At this time, the oral contraceptive is also easy to carry, and it can be easily placed between the lips and gums, which promotes the effect of cytisine on the nicotinic receptors in the human brain that regulate nicotine dependence, thereby increasing the onset speed of the oral contraceptive.
[0056] Furthermore, the content of cytisine in the oral congee is 0.2% to 1%.
[0057] In this embodiment, cytisine can provide mild biological activity within the content range of 0.2% to 1%, promoting the sedative and relaxing effects of the oral substance; secondly, this content range can also avoid poisoning or other side effects of the user, and then, this ratio can enable cytisine to fully exert its effect of alleviating smoking addiction. It should be understood that the content of cytisine can be any one of 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, or a range formed by any two values.
[0058] Furthermore, the oral substance further comprises at least one of a sweetener, a filler, a preservative, an antioxidant, a flavoring agent and a cooling agent.
[0059] In this embodiment, the sweetener can make the oral substance sweet and improve the user experience. The flavoring agent can increase the fragrance of the oral substance and improve the taste experience of the user when taking the oral substance. The cooling agent can create a cool feeling, so that the oral substance has a refreshing effect to a certain extent. The filler can serve as a carrier for the other materials, and when the content of the other materials needs to be adjusted, the adjustment effect can be achieved by changing the content of the filler. The preservative can effectively inhibit the growth of microorganisms and improve the shelf life and safety of the oral substance. The antioxidant can effectively prevent the oxidation of the other materials in the oral substance and maintain the effects of the other materials.
[0060] Further, the sweetener includes at least one of mannitol, glucose, xylitol, sorbitol, sucralose, neotame and powdered sugar; and / or,
[0061] The flavoring agent includes at least one of a liquid flavor and a microcapsule flavor; and / or,
[0062] The cooling agent comprises at least one of WS-23, menthol and borneol; and / or,
[0063] The filler comprises at least one of microcrystalline cellulose, ethyl cellulose and hydroxyethyl cellulose; and / or,
[0064] The preservative includes at least one of benzoic acid and its salts, sorbic acid and its salts, parabens, calcium propionate, sodium lactate and sodium diacetate; and / or,
[0065] The antioxidant includes at least one of vitamin E, ascorbic acid, tea polyphenols and tocopherol.
[0066] In this embodiment, among the above sweeteners: mannitol, glucose, xylitol, and sorbitol can provide natural sweetness, and have the characteristics of low calories or low glycemic index, which are suitable for diabetic patients and consumers with strong health awareness. Sucralose and neotame can provide strong sweetness at very low dosages, reduce calorie intake, and are suitable for people who control their weight and reduce sugar intake. Powdered sugar can provide uniform sweetness, is easy to mix with other ingredients, and ensures the taste stability of the oral substance.
[0067] Among fillers: Microcrystalline cellulose can provide a good taste and physical structure, making the oral congee easier to process, while increasing the chewing texture and volume. Ethyl cellulose and hydroxyethyl cellulose can improve the adhesion and stability of the oral congee, prevent the oral congee from deforming or collapsing during storage and transportation, and extend the shelf life.
[0068] Among preservatives: benzoic acid and its salts, sorbic acid and its salts can effectively inhibit the growth of microorganisms, extend the shelf life of oral consumables, and ensure the safety of oral consumables. Parabens, calcium propionate, sodium lactate, and sodium diacetate can provide a broad spectrum of antibacterial effects, prevent oral consumables from deteriorating, and maintain the stability of their flavor and appearance.
[0069] Among the antioxidants: vitamin E, ascorbic acid, tea polyphenols, and tocopherol can prevent the fat and other easily oxidized components in the oral congee from deteriorating, extend the shelf life, and at the same time maintain the nutritional value and flavor of the oral congee.
[0070] Among flavoring agents: liquid flavors and microcapsule flavors can provide long-lasting fragrance and enhance consumers' sensory experience. Microcapsule flavors can also control the time of fragrance release and maintain the freshness of the fragrance.
[0071] Among the cooling agents: WS-23, menthol, and borneol provide a cool taste, enhance the consumer's comfort, and improve the sensory experience of the oral cavity, making the oral substance more refreshing and pleasant when used.
[0072] Furthermore, the components of the oral congee include a sweetener, the content of the sweetener is 1% to 5%; and / or,
[0073] The components of the oral congee include a flavoring agent, the content of which is 5% to 15%; and / or,
[0074] The components of the oral congee include a cooling agent, the content of the cooling agent is 1% to 5%; and / or,
[0075] The components of the oral concoction include a filler, the content of the filler is 10% to 90%; and / or,
[0076] The components of the oral congee include a preservative, the content of the preservative being 1% to 5%; and / or,
[0077] The components of the oral congee include antioxidants, and the content of the antioxidants is 0.5% to 2%.
[0078] In this embodiment, the range of the sweetener can provide an appropriate sweetness, so that the mouthfeel is pleasant and not too sweet, while also avoiding the health risks caused by excessive intake of sugar, such as blood sugar fluctuations or tooth decay risks.
[0079] The content range of the flavoring agent ensures that the oral consumable can release sufficient and lasting aroma when used, thereby enhancing the sensory appeal of the oral consumable; at the same time, it also helps to maintain the uniformity of the aroma, and prevents the aroma from being too strong and covering up the flavor of other ingredients.
[0080] The range of cooling agents can provide a moderate cooling sensation to the oral substance, adding comfort and pleasure during use; at the same time, it can also ensure that the cooling taste is not too irritating, so that while maintaining the cooling effect, it will not cause a strong sense of numbness or discomfort.
[0081] The range of fillers can adjust the physical form, texture and chewing sensation of the oral congee; at low content, fillers can provide moderate volume and structure to the oral congee; at high content, fillers can significantly increase the volume and chewing durability of the oral congee, allowing it to release active ingredients in the mouth for a longer time.
[0082] The range of preservatives can effectively inhibit the growth of microorganisms, ensuring that the oral consumables remain safe and stable during a long storage period; they can also keep the taste and efficacy of the oral consumables unaffected by time.
[0083] The content of antioxidants can effectively prevent the active ingredients in the oral concoctions from oxidizing and deteriorating, maintaining their stability and effectiveness; it can also avoid potential bad taste or chemical reactions caused by excessive antioxidant content.
[0084] It should be understood that the content of the sweetener can be any one of 1%, 2%, 3%, 4%, 5% or a range formed by any two values. The range of the flavoring agent can be any one of 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15% or a range formed by any two values. The range of the cooling agent can be any one of 1%, 2%, 3%, 4%, 5% or a range formed by any two values. The range of the filler can be any one of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% or a range formed by any two values. The content of the antioxidant can be any one of 0.2%, 0.3%, 0.4%, 0.5% or a range formed by any two values.
[0085] Furthermore, the components of the oral congee include cytisine, microcrystalline cellulose, glucose, WS-23, sorbic acid, vitamin E, and microcapsule flavor.
[0086] In this embodiment, the components of the oral consumables include cytisine, microcrystalline cellulose, glucose, WS-23, sorbic acid, vitamin E, and microcapsule flavors, which can make the oral consumables have a sweetness, fragrance, and coolness that are more suitable for ordinary consumers, while also having good stability and shelf life.
[0087] Furthermore, the content of cytisine is 0.8%, the content of microcrystalline cellulose is 81.2%, the content of glucose is 3%, the content of cooling agent is 2%, the content of microcapsule flavor is 10%, the content of vitamin E is 1%, and the content of sorbic acid is 2%.
[0088] In this embodiment, the content of cytisine is 0.8%, which can ensure that its biological activity and pharmacological effects are fully exerted in the oral consumables, thereby achieving the effect of completely stopping smoking addiction, while avoiding the bitterness or other adverse taste effects caused by excessive concentrations. The content of microcrystalline cellulose provides the oral consumables with good physical form, texture and structural stability, ensuring that the oral consumables can quickly and evenly release active ingredients in the mouth and maintain a suitable taste. The content of microcapsule flavor provides the oral consumables with moderate sweetness, masks the bitterness of cytisine, and enhances the overall taste pleasure. The content of WS-23 can bring a moderate cool feeling to the oral consumables, which complements the mint flavor and brings a refreshing and lasting experience to users.
[0089] The content of microencapsulated flavor is 10%, which ensures the sufficient and lasting aroma and enhances the overall taste experience. The content of vitamin E as an antioxidant is 1%, which can effectively protect the active ingredients in the oral congee from oxidation and extend the shelf life of the oral congee while maintaining its effectiveness and stability. The content of sorbic acid can effectively inhibit the growth of microorganisms and ensure the safety and stability of the oral congee. In summary, the combination of the components of the oral congee of the embodiment of the present application in the above-mentioned proportions achieves the best balance of functionality, stability, taste and user experience, ensuring that the effect of the oral congee is optimal.
[0090] Accordingly, please refer to Figure 1 The present application also provides a method for preparing a buccal substance, the method comprising the following steps:
[0091] S100, providing prefabricated materials and cytisine;
[0092] S200, mixing and stirring the prefabricated material and cytisine to form a concoction.
[0093] In this embodiment, cytisine can selectively act on the nicotinic receptors in the human brain that regulate nicotine dependence, thereby achieving the purpose of reducing nicotine withdrawal symptoms. The oral substance prepared in the embodiment of the present application contains cytisine, so when the user takes the oral substance, the cytisine component can relieve the addiction to smoking, thereby achieving the effect of quitting tobacco. At the same time, the preparation method of the embodiment of the present application only needs to mix and stir cytisine and prefabricated materials to prepare the oral substance, so it also has the beneficial effects of simple production process and high production efficiency.
[0094] Further, the step of providing the prefabricated material and cytisine comprises the following steps:
[0095] At least one of a sweetener, a filler, a preservative, an antioxidant, a flavoring agent and a cooling agent is selected as the prefabricated material.
[0096] In the present embodiment, the sweetener can make the oral substance sweet and improve the user experience. The flavoring agent can increase the fragrance of the oral substance and improve the taste experience of the user when taking the oral substance. The cooling agent can create a cool feeling, so that the oral substance can have a certain degree of refreshing effect. The filler can serve as a carrier of the other materials, and when the content of the other materials needs to be adjusted, the content can be adjusted by changing the content of the filler. The preservative can effectively inhibit the growth of microorganisms and improve the shelf life and safety of the oral substance. The antioxidant can effectively prevent the oxidation of the other materials in the oral substance and maintain the effects of the other materials. In summary, the oral substance prepared in this embodiment can have suitable sweetness, refreshing effect and taste; at the same time, it can also have a longer shelf life.
[0097] Further, the sweetener includes at least one of mannitol, glucose, xylitol, sorbitol, sucralose, neotame and powdered sugar; and / or,
[0098] The flavoring agent includes at least one of a liquid flavor and a microcapsule flavor; and / or,
[0099] The cooling agent comprises at least one of WS-23, menthol and borneol; and / or,
[0100] The filler comprises at least one of microcrystalline cellulose, ethyl cellulose and hydroxyethyl cellulose; and / or,
[0101] The preservative includes at least one of benzoic acid and its salts, sorbic acid and its salts, parabens, calcium propionate, sodium lactate and sodium diacetate; and / or,
[0102] The antioxidant includes at least one of vitamin E, ascorbic acid, tea polyphenols and tocopherol.
[0103] Further, the content of cytisine is 0.2% to 1%; and / or,
[0104] The components of the prefabricated material include a sweetener, the content of the sweetener is 1% to 5%; and / or,
[0105] The components of the prefabricated material include a flavoring agent, the content of which is 5% to 15%; and / or,
[0106] The components of the prefabricated material include a cooling agent, the content of the cooling agent is 1% to 5%; and / or,
[0107] The components of the prefabricated material include a filler, the content of the filler is 10% to 90%; and / or,
[0108] The components of the prefabricated material include a preservative, the content of the preservative is 1% to 5%; and / or,
[0109] The components of the prefabricated material include an antioxidant, and the content of the antioxidant is 0.5% to 2%.
[0110] Next, the performance of the oral substance in this solution is further analyzed by examples, as shown in the following examples:
[0111] Example 1
[0112] The preparation method of the oral substance of the present embodiment is as follows:
[0113] Step 1, take 0.5 parts of cytisine, 81.5 parts of microcrystalline cellulose, 3 parts of glucose, 2 parts of WS-23, 2 parts of sorbic acid, 1 part of vitamin E, and 10 parts of mint microcapsule flavor, put them into a mixer, mix them evenly, and obtain a mixture;
[0114] Step 2: Use a packaging machine to pack the above mixture into small bags, with each bag containing 0.35g of powder and the bag size being 30mm long and 12mm wide;
[0115] Step 3: Put the small bags into plastic boxes, 20 bags per box, the box size is 70mm in diameter and 24mm in height.
[0116] Example 2
[0117] This embodiment is basically the same as Embodiment 1, except that: in step 1 of the present application, 0.2 parts of cytisine and 81.8 parts of microcrystalline cellulose are used.
[0118] Example 3
[0119] This embodiment is basically the same as Embodiment 1, except that: in step 1 of the present application, 0.8 parts of cytisine and 81.2 parts of microcrystalline cellulose are used.
[0120] Comparative Example
[0121] This comparative example is basically the same as Example 1, except that: in step 1 of the present application, 0 parts of cytisine and 82 parts of microcrystalline cellulose are used.
[0122] The differences between Examples 1 to 3 and the comparative example are shown in Table 1 below.
[0123] Under the same conditions, 10 smokers were selected to use the mouthpiece when they had a craving for cigarettes (put the mouthpiece between the upper lip and gums for 30 minutes) to examine the taste experience during use and the degree of relief from the craving after using the product. Based on the observation and measurement, the above Examples 1 to 3 and the comparative example were compared to form Table 2:
[0124]
[0125] Table 1
[0126] Serial number Test Results Example 1 Mint aroma, no obvious discomfort, basically no smoking addiction after use Example 2 Mint aroma, no obvious discomfort, still have a slight craving for cigarettes after use Example 3 Mint aroma, no obvious discomfort, no smoking addiction after use Comparative Example Mint aroma, no obvious discomfort, still addictive after use
[0127] Table 2
[0128] According to Table 2 above, we can know that:
[0129] According to the data of Examples 1 to 3 and the comparative example, through the drying and foaming process. First, Examples 1 to 3 can effectively relieve the craving for cigarettes; second, because the content of cytisine in Example 2 is relatively low, the testers still have a slight craving for cigarettes after taking it, that is, it proves that the reduction of the content of cytisine will lead to a decrease in the relieving effect of craving for cigarettes; then, after taking it, the testers in Examples 1 to 3 have a reduced craving for cigarettes as the content of cytisine increases, indicating that after the content of cytisine increases, it can play a role in blocking the craving for cigarettes; finally, Examples 1 to 3 and the comparative example all have a mint aroma, and the user will not feel uncomfortable, proving that the oral substance of the embodiment of the present application has a good taste and will not cause vomiting and other discomfort to the user.
[0130] Obviously, the embodiments described above are only some embodiments of the present application, rather than all embodiments. The preferred embodiments of the present application are given in the accompanying drawings, but they do not limit the patent scope of the present application. The present application can be implemented in many different forms. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive. Although the present application is described in detail with reference to the aforementioned embodiments, for those skilled in the art, it is still possible to modify the technical solutions recorded in the aforementioned specific implementation methods, or to perform equivalent replacement of some of the technical features therein. Any equivalent structure made using the contents of the specification and drawings of this application, directly or indirectly used in other related technical fields, is similarly within the scope of patent protection of this application.
[0131] Although the embodiments of the present application have been shown and described, those skilled in the art will appreciate that various changes, modifications, combinations, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present application, and that the scope of the present invention is defined by the claims and their equivalents.
Claims
1. A buccal substance, characterized in that: The components of the lozenge include cytisine.
2. The oral substance according to claim 1, characterized in that In the components of the oral concoction, the content of cytisine is 0.2% to 1%.
3. The oral substance according to claim 1, characterized in that The oral substance further comprises at least one of a sweetener, a filler, a preservative, an antioxidant, a flavoring agent, and a cooling agent.
4. The oral substance according to claim 3, characterized in that The sweetener comprises at least one of mannitol, glucose, xylitol, sorbitol, sucralose, neotame and powdered sugar; and / or, The flavoring agent includes at least one of a liquid flavor and a microcapsule flavor; and / or, The cooling agent comprises at least one of WS-23, menthol and borneol; and / or, The filler comprises at least one of microcrystalline cellulose, ethyl cellulose and hydroxyethyl cellulose; and / or, The preservative includes at least one of benzoic acid and its salts, sorbic acid and its salts, parabens, calcium propionate, sodium lactate and sodium diacetate; and / or, The antioxidant includes at least one of vitamin E, ascorbic acid, tea polyphenols and tocopherol.
5. The oral substance according to claim 3, characterized in that The components of the oral concoction include a sweetener, and the content of the sweetener is 1% to 5%; and / or, The components of the oral congee include a flavoring agent, wherein the content of the flavoring agent is 5% to 15%; and / or, The components of the oral substance include a cooling agent, wherein the content of the cooling agent is 1% to 5%; and / or, The components of the oral concoction include a filler, and the content of the filler is 10% to 90%; and / or, The components of the oral congee include a preservative, and the content of the preservative is 1% to 5%; and / or, The components of the oral concoction include an antioxidant, and the content of the antioxidant is 0.5% to 2%.
6. The oral substance according to claim 4, characterized in that The components of the oral congee include microcrystalline cellulose, glucose, WS-23, sorbic acid, vitamin E and microcapsule flavor.
7. The oral substance according to claim 6, characterized in that The content of cytisine is 0.8%, the content of microcrystalline cellulose is 81.2%, the content of glucose is 3%, the content of cooling agent is 2%, the content of microcapsule flavor is 10%, the content of vitamin E is 1%, and the content of sorbic acid is 2%; and / or, The oral substance is in powder form.
8. A method for preparing a buccal substance, characterized in that: The method comprises the following steps: providing prefabricated materials and cytisine; The prefabricated material and the cytisine are mixed and stirred to form a mouthful.
9. The preparation method according to claim 8, characterized in that: The step of providing the prefabricated material and cytisine comprises the following steps: At least one of a sweetener, a filler, a preservative, an antioxidant, a flavoring agent and a cooling agent is selected as the prefabricated material.
10. The preparation method according to claim 9, characterized in that: The sweetener comprises at least one of mannitol, glucose, xylitol, sorbitol, sucralose, neotame and powdered sugar; and / or, The flavoring agent includes at least one of a liquid flavor and a microcapsule flavor; and / or, The cooling agent comprises at least one of WS-23, menthol and borneol; and / or, The filler comprises at least one of microcrystalline cellulose, ethyl cellulose and hydroxyethyl cellulose; and / or, The preservative includes at least one of benzoic acid and its salts, sorbic acid and its salts, parabens, calcium propionate, sodium lactate and sodium diacetate; and / or, The antioxidant comprises at least one of vitamin E, ascorbic acid, tea polyphenols and tocopherol; and / or, The components of the prefabricated material include a sweetener, and the content of the sweetener is 1% to 5%; and / or, The components of the prefabricated material include a flavoring agent, the content of the flavoring agent is 5% to 15%; and / or, The components of the prefabricated material include a cooling agent, and the content of the cooling agent is 1% to 5%; and / or, The components of the prefabricated material include a filler, and the content of the filler is 10% to 90%; and / or, The components of the prefabricated material include a preservative, the content of the preservative is 1% to 5%; and / or, The components of the prefabricated material include an antioxidant, and the content of the antioxidant is 0.5% to 2%.