Analyzing device with common port

Abstract

An analysis device with a common port is disclosed. An analysis device (100) for analyzing a sample, the analysis device (100) comprising: i) a thermoregulation tank (110) for containing a fluid to provide temperature control of the sample when the sample is contained in the thermoregulation tank (110); and ii) a common port (150) coupled to the thermoregulation tank (110) and including an inlet port (120) and an outlet port (130) therein.

Description

Technical Field

[0001] The present disclosure relates to an analytical device (e.g., a dissolution test device) having a common port in which an inlet port and an outlet port are combined, wherein the analytical device further comprises a temperature-controlled bath coupled to the common port. The present disclosure also relates to a method for analyzing a sample and a specific use of the common port for temperature-controlled fluid in a temperature bath. Background Art

[0002] An analytical device is provided for analyzing a sample, such as for analyzing the dissolution properties of said sample. In some analyses, it may be necessary to keep the sample at a specific temperature during the measurement; in other words, temperature control / regulation is required.

[0003] For example, dissolution testing equipment needs to be able to maintain the sample container (and its media / sample) at a constant set temperature. This is usually achieved by a water bath method or direct heating without a bath. Water bath instruments are the most common due to their temperature stability. Water bath methods are usually a "flow-through" design where water is heated externally by a heating circulator and pumped from one side of the bath to the other.

[0004] Another solution is to use an immersion heater in the bath. Disadvantages of the immersion heater design typically include higher temperature variations across the bath due to the lack of applied flow. This issue can be addressed by adding a stirring device, but this increases cost. Additionally, immersion heaters in the bath take up valuable bath space, increasing water quality, heat-up time, and energy costs. Immersion heaters may obstruct views, creating visibility issues. Finally, immersion heaters typically must be fully submerged to operate safely, increasing startup time.

[0005] In contrast, flow-through baths typically have an inflow port for hot water to enter the bath from the heater and an outflow return port. Each of these ports is typically implemented by a separate hole in the bath container. However, existing designs can have the disadvantage of a high risk of leakage: each port requires a sealing hole in the bath container, and each seal further presents a risk of leakage due to assembly errors / damage.

[0006] Another conventional design has a third port at the lowest point of the bath vessel, which is usually used for drainage and is located at the front. The purpose of this is to create a drain at the front of the instrument that is easily accessible to the user. However, this design adds even another disadvantage: there is an extra hole in the bath vessel that is filled by the port, which can be another failure / leak point.

[0007] US 7,658,198 B2 describes a cleaning system for a dissolution container. The container cleaning machine comprises a nozzle in which a flushing channel and a waste channel are formed. However, the document focuses on cleaning and does not describe a solution for reliably temperature-regulating (heating) a temperature-regulating bath for a sample in the container. Summary of the invention

[0008] It may be desirable to control / regulate a fluid in a temperature controlled bath for sample analysis, in particular dissolution analysis, in an efficient and reliable manner. This object is solved by the independent claim. Further embodiments are shown by the dependent claims.

[0009] According to a first aspect, an analytical device (e.g. a dissolution testing device) for analyzing (e.g. during sample preparation) a sample (e.g. a drug) is described, the analytical device comprising:

[0010] i) a temperature controlled bath for containing a fluid (e.g., a water bath) to provide temperature control (in this context, the term "temperature control" may also include temperature regulation) of a sample (e.g., located in a sample container) when (the fluid and / or the sample) is contained in the temperature controlled bath (110); and

[0011] ii) A common port (especially a single / discrete component) which is coupled to the temperature-controlled bath (especially fluidically coupled) and comprises / combines therein / within an inlet port (eg an inlet channel) and an outlet port (eg an outlet channel).

[0012] According to a second aspect, a method of analyzing a sample is described, the method comprising:

[0013] i) providing the sample into the fluid (eg, into a sample container within the fluid); and

[0014] ii) providing temperature control of the bath, in particular by flowing a fluid from an inlet port in the inlet fluid path through the fluid, and flowing a fluid from a fluid in the outlet fluid path to the outlet port, whereby the inlet port and the outlet port are combined in a single common port (in particular connected to a single opening in the temperature-controlled bath).

[0015] According to a third aspect, a use (method of use) of a common port having an inlet port and an outlet port to control / regulate the temperature of (a sample in) a thermostatic bath with a heating fluid through a single opening of the thermostatic bath is described.

[0016] In the context of this document, the term "comprising" (especially comprising a common port for an inlet port and an outlet port) may also mean storing, containing, comprising, etc.

[0017] In the context of this document, the term "analytical device" may particularly refer to a device suitable for analyzing a sample. In an example, the analytical device is applied to analyze (characterize) the sample by analyzing the dissolution characteristics of the sample. In particular, the analytical device includes a fluid (in a thermostatic bath volume) to place the sample (located in a sample container) at least partially into the fluid so that a desired temperature (range) can be provided during the measurement. In addition to the fluid (in the thermostatic bath), the analytical device may also include an analysis domain, which is configured to perform the actual analysis, such as a dissolution test. For example, the analysis domain may include one or more corresponding sensing devices to monitor the dissolution characteristics of the sample. In addition, the analytical device may include a control device to perform analysis in the analysis domain and / or control / regulate the temperature of the fluid in the thermostatic bath.

[0018] In the context of this document, the term "analysis" may refer to the characterization of at least one property of a sample. For example, a dissolution test is such an analysis. Dissolution can be considered a sample preparation technique, so the term "analysis" in this document may also refer to analytical sample preparation.

[0019] In the context of this document, the term "dissolution test equipment" may particularly refer to an analytical device suitable for performing a dissolution test, particularly for healthcare and / or pharmaceutical samples (such as medicines, etc.). The dissolution test is usually performed using a test device that accommodates a plurality of sample containers and immerses the containers in a temperature-controlled dissolution tank. In a specific conventional example (see US 7,658,198B2), each container is then filled with a dissolution medium in which a solute / sample is placed, and then a stirring element is used to stir the dissolution medium. At some point, one or more samples of the resulting solution are taken out from the container and evaluated, for example, using a spectrophotometer, in situ or by transporting the sample to an external device for evaluation.

[0020] In the context of this document, the term "thermostatic bath" may particularly refer to a defined space suitable for receiving a fluid to provide temperature control / regulation of a sample. In an illustrative example, the thermostatic bath may be implemented as a container or bath filled with a fluid for providing temperature control of the fluid. Water may be considered a preferred choice for the temperature control fluid, but other suitable (liquid) fluids may also be used. The thermostatic bath may be spatially defined by side walls (as well as a bottom and ultimately a cover). The thermostatic bath may further include at least one opening, such as an inlet for a fluid and an outlet / discharge port for a fluid. In a preferred embodiment, the thermostatic bath of the present disclosure includes only a single opening for both an inlet fluid path and an outlet fluid path.

[0021] In the context of this document, the term "port" may particularly refer to a structure suitable for being flowed through by a fluid. For example, an inlet port may be suitable for enabling a thermostatic (providing temperature control) fluid to flow in an inlet fluid path, and an outlet port may be suitable for enabling a (consumed) thermostatic (providing temperature control) fluid to flow in an outlet fluid path. In an illustrative example, a port may be implemented by a channel, a conduit or a capillary. In addition, a port may include (or be coupled to) a valve. A port may terminate with only a (planar) opening, or a more complex structure, such as a nozzle, may be used.

[0022] In the context of this document, the term "fluid path" may particularly refer to a specific flow (characteristic / property) of a fluid. For example, a temperature control fluid (i.e. a fluid suitable for providing temperature control; which is, for example, heated) entering a thermostatic bath may flow through an inlet port and then flow through the bath in a specific manner (e.g. see Figure 1 ). In the same manner, the consumed temperature-controlled fluid (e.g., cooled compared to the fluid in the inlet fluid path) can flow from the temperature-controlled tank to the outlet port in a specific manner and through the outlet port (also compared to Figure 1 ). The change from the inlet fluid path to the outlet fluid path within the temperature-controlled bath may be continuous, so that no precise boundaries can be defined.

[0023] In the context of this document, the term "common port" may particularly refer to a device adapted to comprise an inlet port and an outlet port (see above). Thus, both ports are implemented in a single device, i.e. a common device for ports. Such a common port can be fluidically coupled to a single opening in the thermostatic bath, since all ports are integrated into one and the same device. A number of embodiments of the common port include Figure 1 As shown in Figure 8, it can be seen that even though the inlet port and the outlet port can be implemented as two independent channels, they are still combined in the same device. In the example, the common port is configured as an independent device (single piece) that can be handled / transported separately and then can be directly connected to the temperature control tank.

[0024] According to an exemplary embodiment, the present disclosure may be based on the idea that a temperature-controlled bath for sample analysis (particularly dissolution analysis) can be controlled / regulated in an efficient and reliable manner when the temperature control of the bath is triggered by a fluid providing a temperature control (heating fluid), wherein the fluid providing the temperature control (heating fluid) enters the bath through an inlet port and leaves the bath through an outlet port, wherein the inlet port and the outlet port are combined in a single common port.

[0025] For example, the common port can be compared to a coaxial cable, where two different conductors pass along the same round cable. In this way, a double flow port can be provided, making it possible to form a single opening in the thermostatic bath for inflow, outflow and discharge. The reduction of openings can in particular reduce the risk of leakage while maintaining temperature stability in the thermostatic bath.

[0026] Furthermore, the advantages of a flow-through bath compared to an immersion heating bath (see above) may be enhanced: the heater may not need to use any volume in the bath, may have no line of sight obstructions, and may have inherently better temperature variation / stability.

[0027] Exemplary Embodiments

[0028] Further embodiments of the disclosure are described below: these apply to the apparatus as well as to the method and use.

[0029] In an embodiment, the inlet port is coupled to the thermostatic tank (particularly a single opening) and is configured to supply the fluid (eg, hot water) in the inlet fluid path (heating flow) into the thermostatic tank.

[0030] In an embodiment, the outlet port is coupled to the tempered tank (particularly a single opening) and is configured to discharge (exit) the fluid (eg, cold water) in the outlet fluid path from the tempered tank.

[0031] In an embodiment, the analytical device is configured to analyze samples in a health care and / or pharmaceutical context. In this case, the sample to be analyzed can be a drug. In this context, the term "drug" may refer to a chemical substance (and particularly different from general food) that may be suitable for causing physiological / psychological changes in an organism. In the context of health care / pharmacy, analysis is generally highly regulated, such as with reference to good laboratory practice (GLP) and good manufacturing practice (GMP) guidelines. In particular, in the approval / access procedure or quality control process of a drug, very high standards may need to be reached in a health care / pharmacy context. In order to meet the high standards, analytical conditions, particularly temperature stability, may have to be very accurate and repeatable. The described analytical device can meet such high-precision requirements based on reliable and efficient temperature control / regulation. Therefore, the analytical device can be configured to control the temperature to meet the dissolution rule.

[0032] In the context of this document, the term "health care" may refer to diagnostics / treatment, while the term "pharmaceutical" may refer to the manufacture of treatments. However, there may be some overlap between these areas.

[0033] In another embodiment, the common port (particularly the inlet port and the outlet port) is fluidly connected to a single opening of the thermostatic tank. Thus, the risk of leakage can be reduced and stability can be improved. The single opening in the thermostatic tank can make it possible to implement only one interface that needs to be sealed. Compared with the flow port, the openings in the thermostatic tank are fewer (for example, two ports (inlet, outlet) or three ports (inlet, outlet, exhaust port) compared to one port in the thermostatic tank) can reduce the risk of leakage. In an embodiment, the thermostatic tank includes only a single opening. In another embodiment, the thermostatic tank includes two or more openings, but only one opening is used for the common port.

[0034] In another embodiment, the analytical device is configured such that the temperature of the fluid in the inlet fluid path is higher / lower than the temperature of the fluid in the outlet fluid path, in particular wherein the fluid is used to provide temperature control (heating the fluid). This may provide the advantage that the established concept of temperature control of the fluid in the fluid tank may be implemented in a straightforward manner. However, this concept may be highly improved in terms of efficiency and reliability when the inlet fluid and the outlet fluid are made to flow through the same port arrangement. Within the thermostatic tank, the fluid of the inlet fluid path (having a higher temperature than the thermostatic tank fluid) may cool to become the fluid of the outlet fluid path (having the same or lower temperature than the thermostatic tank fluid).

[0035] In another embodiment, the fluid used to provide temperature control can be used to cool the thermostatic bath (fluid).Thus, the fluid of the inlet fluid path will have a lower temperature than the fluid of the outlet fluid path.

[0036] In another embodiment, the common port comprises a nozzle coupled to the inlet port and configured to allow the fluid in the inlet fluid path to flow into the thermostatic tank. This can provide the advantage that the fluid is distributed to the thermostatic tank fluid in an efficient manner, in particular away from the outlet fluid path (which will cool the inlet fluid). The nozzle may include a bend so that the flow direction of the fluid in the inlet fluid path is at least partially changed. The nozzle may have the same diameter as the inlet port or a different diameter, in particular a wider diameter. In examples, the diameter of the nozzle changes, in particular becomes larger with the flow direction.

[0037] In another embodiment, the nozzle is configured to change the flow direction of the fluid in the inlet fluid path (in a substantially right-angled manner), in particular by an angle greater than 30°, in particular greater than 60°, in particular (approximately) 90°, when the fluid in the inlet fluid path enters the thermostatic bath. Thus, the flow direction can be changed in a practical and simple manner, thereby achieving an efficient inlet flow path that initially flows away from the outlet fluid path.

[0038] In another embodiment, the common port comprises an opening at the outlet port, wherein the opening is configured to allow the fluid in the outlet fluid path to flow out of the temperature control tank, in particular in a constant flow direction, more particularly supported by gravity (in particular passively). This embodiment can achieve an efficient outlet fluid path that flows toward and directly into the outlet port.

[0039] In another embodiment, the analytical device further comprises a connection device, which is coupled to the common port and is configured to further connect the inlet fluid path and / or the outlet fluid path. Thus, the common port can be directly implemented as a flexible temperature control system. The connection device can be implemented as a manifold block, which allows the connection of channel-like structures such as hoses.

[0040] In another embodiment, the analytical device further comprises a heating connection (e.g., a hose) coupled to the common port or connection means and configured to supply the fluid from the heating means to the inlet fluid path. In this context, a "heating" means may be any means suitable for increasing the temperature of the fluid. In another example, in the case where the thermostatic bath should be cooled, the heating means may be replaced by a cooling means.

[0041] In another embodiment, the analytical device includes an exhaust connection (e.g., a hose) coupled to a common port or connection device and configured to discharge the fluid from the outlet fluid path to an exhaust device (e.g., a valve; configured to discharge the fluid from a temperature control system) and / or to allow the fluid to flow from the outlet fluid path to a heating device (or cooling device). In the latter case, the consumed fluid can be reheated and flowed to the inlet port, thereby achieving an efficient and environmentally friendly cycle.

[0042] In another embodiment, the analytical device is configured to control and / or regulate the temperature of the fluid in the thermostatic bath, particularly based on the fluid temperature and / or fluid flow rate. For example, the analytical device may include a control device (which may also be remotely operated) that determines the desired temperature of the sample. Different parameters may be considered to control the temperature in the thermostatic bath. An important parameter may be the temperature of the inlet port fluid. Flow rate may describe how much fluid may be pumped through the volume. Pressure may be derived from flow rate, flow velocity, and the hydraulic diameter in the port, and will affect the distance that the flow is "ejected" into the bath.

[0043] In another embodiment, the analytical device further comprises: a fluid in the thermostatic bath, in particular wherein the inlet fluid path flows into the thermostatic bath as heated (or cooled) fluid, and in particular wherein the outlet fluid path flows out of the thermostatic bath as consumed, in particular cooled (or heated) fluid. As described above, such operation can achieve an efficient flow path of the fluid through the thermostatic bath, thereby achieving precise temperature control of the sample.

[0044] In another embodiment, the analytical device further comprises: one or more sample containers arranged in the thermostatic bath, wherein the one or more sample containers are configured to take a sample therein. This may provide the advantage that established and standardized principles of dissolution measurements may be directly implemented. In another embodiment, the common port is configured to control the temperature of the one or more sample containers based on controlling the temperature of the thermostatic bath fluid.

[0045] In another embodiment, the analytical device is configured as a dissolution test device, in particular configured to simulate the dissolution of a sample relative to a patient's stomach. Therefore, the advantages of the present disclosure can be directly transferred to dissolution testing, which generally requires a high level of accuracy and reliability. The sample for the dissolution test is typically a drug, and its dissolution characteristics in a patient's (human or animal) stomach can be simulated in a sample container. For example, the sample container can have a low pH value (high acid content) and / or multiple enzymes.

[0046] In another embodiment, the common port comprises a tapered shape, in particular wherein the tapering direction is away from the temperature regulating tank.

[0047] In another embodiment, the common port comprises an upper portion and a lower portion, wherein the upper portion is spatially closer to the tank volume than the lower portion, and wherein the upper portion comprises a greater width than the lower portion.

[0048] In another embodiment, wherein the common port comprises a funnel-like shape, these shapes can improve the fluid connection with the (single) opening of the thermostatic bath.

[0049] In another embodiment, the common port includes a connection / cover plate on the upper portion and / or the top of the funnel shape. Such a cover-like structure can cover the top of the common port to prevent fluid from entering the common port other than the port.

[0050] In another embodiment, the nozzle protrudes from the funnel shape and / or the connecting plate. Thus, the nozzle can improve the inlet fluid path flow when entering the temperature control tank fluid.

[0051] In another embodiment, the common port comprises an inner part, which comprises an inlet port and an outlet port. In another embodiment, the common port comprises an outer part at least partially surrounding the inner part (especially completely surrounding). Therefore, the outer part can play a role in stabilizing the inner part.

[0052] In another embodiment, the common port is configured as a discrete (fluid and port can be separated from the rest of the instrument) (particularly a stand-alone device, a single piece). Thus, the common port can be applied in a design-flexible manner. Even if the inlet port and the outlet port (and potentially the exhaust port) are separated in the common port, the latter is still a discrete structure that combines the two ports.

[0053] In another embodiment, the outlet port is arranged at the lowest part of the temperature control tank, in particular with respect to the direction of gravity. This position allows for a particularly efficient drainage of the outlet fluid path.

[0054] In another embodiment, the flow direction of the inlet fluid path and / or the flow direction of the outlet fluid path is (substantially) vertical, in particular (substantially) parallel to the direction of gravity. In other words, the common port is connected to the thermostatic tank at the bottom. Thereby, an efficient outlet fluid path flow can be achieved. In contrast, the inlet fluid path may require an elevated flow (in particular pressure) for efficient flow.

[0055] In another embodiment, the method further comprises: performing a dissolution test, in particular in a healthcare and / or pharmaceutical context (see description above).

[0056] In another embodiment, the method further comprises: circulating the fluid between the outlet port and the inlet port. In particular, wherein such circulation comprises (through) a heating device (or a cooling device). This may provide the advantage that a circulation may be established and the consumed fluid may be (at least partially) recirculated by further temperature control (heating or cooling).

[0057] In an exemplary embodiment, the common port combines the inlet port and the outlet port in a single component. In an exemplary embodiment, the common port includes a Y-shaped component / port. The component can be located in a thermostatic tank (fluid) and can be used to form a sealing surface to prevent fluid / water leakage. In an exemplary embodiment, the common port can be produced at least in part by injection molding. In another example, the common port can be produced at least in part by additive manufacturing (3D printing). In another example, the common port can be machined (formed by mechanical actions such as drilling). In an exemplary embodiment, the common port at least partially includes plastic. Plastic can provide the advantage of low thermal conductivity. In another example, any insulating, waterproof, low permeability material can be used (advantageously). BRIEF DESCRIPTION OF THE DRAWINGS

[0058] Other objects and many attendant advantages of the present invention will be readily appreciated and better understood by referring to the following more detailed description of the embodiments in conjunction with the accompanying drawings. Features that are substantially or functionally equivalent or similar will be designated by the same reference numerals.

[0059] Figure 1 An analytical device having a common port and fluid flow path is shown according to an exemplary embodiment.

[0060] Figure 2 A common port according to an exemplary embodiment is shown.

[0061] Figure 3 An analysis device with a shared port according to a further exemplary embodiment is shown.

[0062] Figure 4 An analytical device having a common port with a nozzle is shown according to an exemplary embodiment.

[0063] Figure 5 An analysis device with a connection device according to an exemplary embodiment is shown.

[0064] Figure 6 A cross section through a common port is shown according to an exemplary embodiment.

[0065] Figure 7 An analytical device having a common port connected to a bath volume according to an exemplary embodiment is shown.

[0066] FIG. 8A to FIG. 8E Common ports according to exemplary embodiments are respectively illustrated. DETAILED DESCRIPTION

[0067] Referring now in more detail to the accompanying drawings, Figure 1 An analytical device 100 having a common port 150 and a fluid flow path according to an exemplary embodiment is depicted. The analytical device 100 includes a temperature-controlled bath 110 (here a water container) for containing a fluid (here water) to provide temperature control for a sample. The analytical device 100 is a dissolution testing device, and the sample is provided in a sample container placed in a fluid (not shown).

[0068] The common port 150 is fluidly connected (i.e., a connection capable of fluid exchange) to a single opening in the thermostatic tank 110. The common port 150 includes an inlet port 120 and an outlet port 130, each of which is fluidically coupled to a single opening in the thermostatic tank 110. Through the inlet port 120, a heated fluid (e.g., hot water) is supplied to the thermostatic tank 110 in an inlet fluid path 121 (in other words, a hot fluid path, as indicated by an arrow). Through the outlet 130, the consumed fluid (e.g., cold water) is discharged from the thermostatic tank 110 in an outlet fluid path 131 (in other words, a cold fluid path, as indicated by an arrow). In other words, the temperature of the fluid in the inlet fluid path 121 is higher than the temperature of the fluid in the outlet fluid path 131.

[0069] In the example shown, the thermostatic bath 110 is filled with a thermostatic bath fluid, wherein the inlet fluid path 120 flows into the thermostatic bath fluid as a heated fluid, and wherein the outlet fluid path 130 flows out of the thermostatic bath fluid as a cooled fluid. Thus, based on the temperature of the heated fluid (and the flow rate of the provided fluid), the analytical device 100 is configured to regulate the temperature of the fluid in the thermostatic bath 110.

[0070] The analytical device 100 further comprises a heating device 160, which is fluidically coupled to the outlet port 130, so that the (consumed) fluid flows to the heating device 160 in the outlet fluid path 131. In the heating device 160, the fluid is again temperature-conditioned (heated) and then provided to the inlet fluid path 121 to flow back into the temperature-controlled bath 110 through the inlet port 120. In this way, an efficient circulation of the temperature-controlled fluid can be established. Also shown is a discharge device 170, such as a discharge valve, for discharging the (consumed) fluid out of the temperature control system.

[0071] Figure 2 A common port 150 according to an exemplary embodiment is shown. In this basic embodiment, the common port 150 includes two channels oriented parallel to each other. In addition, both channels are oriented vertically, i.e., along the direction of gravity. When the left channel is the inlet port 120 for the inlet fluid path 121, the right channel is the outlet port 130 for the outlet fluid path 131. The common port 150 includes a tapered shape, wherein the tapered direction is toward the direction of gravity (away from the thermostatic tank 110). In other words, the common port 150 includes a funnel-shaped shape. The upper (widest) portion of the common port 150 (shown as the inner portion 152) can be connected to a single opening of the thermostatic tank 110.

[0072] Figure 3 FIG. 1 shows an analysis device 100 having a common port 150 according to another exemplary embodiment. Figure 2 The port of the thermostatic tank 110 is relatively large (however, the funnel-like shape is less pronounced) and is fluidically connected to the single opening of the thermostatic tank 110. The fluid connection is preferably established at the lowest part / point of the thermostatic tank 110. Due to this position, a particularly efficient drainage of the outlet fluid path 131 supported by gravity (downward in the vertical direction) can be achieved.

[0073] Furthermore, it has been shown that the fluid of the inlet fluid path 121 (preferably flowing into the tempering tank fluid at a sufficient pressure) is distributed over the fluid so that the tank can be tempered efficiently.

[0074] Figure 4 1 shows an analytical device 100 having a common port 150 with a nozzle 155 according to an exemplary embodiment. Figure 3 The common port 150 comprises a straight (cylindrical) shape (rather than a funnel shape) and extends into the temperature-controlled tank 110. Although the outlet port 130 is configured as a vertical channel (such as Figure 3 ), and is connected to the temperature control bath 110 via a simple opening 135, but the inlet port 120 includes a nozzle 155 through which the inlet fluid path 121 enters the temperature control path.

[0075] The nozzle 155 guides the inlet fluid path 121 and is able to change the flow direction of the fluid in the inlet fluid path 121 when it enters the thermostatic bath 110. In the example shown, the change in flow direction is, for example, 90°, i.e., the flow direction changes from vertical flow to horizontal flow. Since the common port 150 extends into the thermostatic bath 110, the nozzle 155 enables the heating fluid to efficiently flow into the bath and leave the outlet fluid path 131. Therefore, the hot fluid and the consumed fluid can be separated more efficiently in space, thereby improving the circulation of the heating fluid in the thermostatic bath fluid. In contrast, for the outlet port 130, the opening 135 can provide the most efficient discharge because it can be directly supported by gravity.

[0076] Figure 5 1 shows an analytical device 100 with a connection device 180 according to an exemplary embodiment. In this embodiment, the common port 150 extends into the temperature-controlled bath 110, such as Figure 4 Shown in detail. Figure 5 The focus is on the connection device 180 which is spatially located below the common port 150. In other words, the common port 150 is mounted on the connection device 180. The latter comprises two connections (in addition to the connection to the common port 150), a heating connection 161 and a discharge connection 171. These connections 161, 171 are in this example terminals which are configured, for example, to be connected to a channel-like structure such as a hose or the like.

[0077] The inlet port 120 and the inlet fluid path 121 are fluidly connected to the heating connection 161 so that heated fluid (e.g., from the heating device 160) can be supported. In contrast, the outlet port 130 and the outlet fluid path 131 are fluidly connected to the exhaust connection 171 so that the consumed fluid can be exhausted, for example, through the exhaust valve 170 and / or flow to the heating device 160 to circulate in the temperature control system.

[0078] Figure 6A cross section through a common port 150 is shown according to an exemplary embodiment. In this preferred example, the common port 150 comprises a funnel-like shape with two separate (but combined in the same device) channels, one channel being the outlet port 130 (see arrow) for the outlet fluid path 131, and the other channel being the inlet port 120 (see arrow) for the inlet fluid path 121. The outlet port 130 comprises a planar opening 135 at the interface with the temperature control tank fluid, while the inlet port 120 comprises a nozzle 155. The nozzle 155 is an enlarged flow structure that directs the inlet fluid path 121 from a vertical direction to a horizontal direction, thereby away from the outlet fluid path 131.

[0079] Figure 7 An analysis device 100 according to an exemplary embodiment is shown with a common port 150 connected to a tank volume 110. In this example, the common port 150 mounted on a connection device 180 is provided with a nozzle 155 and an opening 135 arranged in the temperature-controlled tank 110.

[0080] FIG. 8A to FIG. 8E Common ports 150 according to exemplary embodiments are respectively shown.

[0081] Fig. 8A : The connecting plate 156 covers the top of the common port 150, leaving an open nozzle 155 and a planar opening 135. The connecting plate 156 can be pressed against the outer wall of the thermostatic tank 110, or it can be located inside the thermostatic tank 100.

[0082] Figure 8B :The cross section (compared Figure 6 ) shows in detail the connection between the common port 150 and the connecting device 180, wherein the connecting device 180 includes a heating connecting piece 161 and a discharge connecting piece 171.

[0083] Figure 8C : This exploded view shows an embodiment in which the common port 150 comprises an inner portion 152 having an inlet port 120 and an outlet port 130, and an outer portion 151 circumferentially surrounding the inner portion 152. A connection plate 156, a heating connection 161, a drain connection 171 and a connection device 180 are also shown.

[0084] Fig.8D : This embodiment shows in detail the connection plate 156 with an open space for the nozzle 155 and the opening 135.

[0085] Fig. 8E An example of an outer portion 151 having a funnel-like shape is shown.

[0086] It should be noted that the term "comprising" does not exclude other elements, and "a" or "an" does not exclude a plurality. Moreover, elements described with respect to different embodiments may be combined. It should also be noted that the reference signs in the claims should not be interpreted as limiting the scope of the claims.

[0087] Reference numerals list

[0088] 100 Analytical Equipment

[0089] 110 Temperature Control Tank

[0090] 120 Inlet Port

[0091] 121 Inlet fluid path

[0092] 130 Exit port

[0093] 131 Outlet fluid path

[0094] 135 Opening

[0095] 150 Shared Ports

[0096] 151 External common port part

[0097] 152 Internal shared port part

[0098] 155 Nozzle

[0099] 156 Connecting plate

[0100] 160 Heating device

[0101] 161 Heating connection

[0102] 170 Discharge device

[0103] 171 Discharge connection

[0104] 180 Connecting device

Claims

1. An analysis device (100) for analyzing a sample, the analysis device (100) comprising: a temperature-controlled bath (110) for containing a fluid to provide temperature control of the sample when the sample is contained in the temperature-controlled bath (110); and A common port (150) is coupled to the temperature-controlled bath (110) and includes an inlet port (120) and an outlet port (130) therein.

2. The analysis device (100) according to claim 1, comprising at least one of the following: The inlet port (120) is coupled to the temperature regulating tank (110) and is configured to supply the fluid in the inlet fluid path (121) into the temperature regulating tank (110); The outlet port (130) is coupled to the thermostatic tank (110) and is configured to discharge fluid in an outlet fluid path (131) from the thermostatic tank (110).

3. The analysis device (100) according to claim 1 or 2, comprising at least one of the following: The analytical device (100) is configured to analyze the sample in a healthcare and / or pharmaceutical context; The analytical device (100) is a dissolution testing device configured to simulate dissolution of the sample.

4. The analysis device (100) according to any one of the preceding claims, in, The common port (150), in particular the inlet port (120) and the outlet port (130), are fluidly connected to a single opening of the temperature-controlled tank (110).

5. The analysis device (100) according to any of the preceding claims 2 to 4, The method is configured such that the temperature of the fluid in the inlet fluid path (121) is higher than the temperature of the fluid in the outlet fluid path (131), in particular wherein: The fluid is used as a heating fluid.

6. The analysis device (100) according to any of the preceding claims 2 to 5, in, The common port (150) includes a nozzle (155) coupled to the inlet port (120) and configured to allow the fluid in the inlet fluid path (121) to flow into the temperature regulating tank (110).

7. The analysis device (100) according to claim 6, in, The nozzle (155) is configured to change the flow direction of the fluid in the inlet fluid path (121) when the fluid enters the temperature regulating tank (110), particularly at an angle greater than 30°, particularly greater than 60°, particularly about 90°.

8. The analysis device (100) according to any of the preceding claims 2 to 7, in, The common port (150) comprises an opening (135) at the outlet port (130), wherein the opening (135) is configured to allow the fluid in the outlet fluid path (131) to flow out of the temperature regulating tank (110), particularly in a constant flow direction, more particularly supported by gravity.

9. The analysis device (100) according to claims 2 to 8, further comprising: A connection device (180) is coupled to the common port (150) and is configured to further connect the inlet fluid path (121) and / or the outlet fluid path (131).

10. The analysis device (100) according to claim 9, further comprising: a heating connection (161) coupled to the connection device (180) and configured to supply the fluid from the heating device (160) to the inlet fluid path (121); and / or A discharge connection (171) is coupled to the connection device (180) and is configured to discharge the fluid from the outlet fluid path (131) to the discharge device (170) and / or to allow the fluid to flow from the outlet fluid path (131) to the heating device (160).

11. The analysis device (100) according to claims 2 to 10, further comprising: The fluid in the temperature regulating tank (110) The inlet fluid path (120) flows into the thermostatic tank fluid as a heated fluid, and the outlet fluid path (130) flows out of the thermostatic tank fluid as a consumed, in particular cooled, fluid.

12. The analysis device (100) according to the preceding claim, further comprising: One or more sample containers are arranged in the temperature regulating bath (110), wherein the one or more sample containers are configured to ingest the sample therein.

13. The analysis device (100) according to claim 12, in, The common port (150) is configured to temperature-regulate the one or more sample containers based on providing temperature control to the fluid in the temperature-regulating bath (110).

14. The analysis device (100) according to the preceding claim, configured as a dissolution test device, in particular configured to simulate the dissolution of the sample with respect to a patient's stomach.

15. The analysis device (100) according to any one of the preceding claims, in, The common port (150) comprises a tapered shape, wherein the tapered direction is away from the temperature regulating tank (110); wherein the common port (150) comprises an upper portion and a lower portion, wherein the upper portion is spatially closer to the tank volume (110) than the lower portion, and wherein the upper portion comprises a greater width than the lower portion; wherein the common port (150) comprises a funnel shape; wherein the common port (150) comprises a connection plate (156) on the upper portion and / or the top of the funnel shape; wherein the pipe opening (155) protrudes from the funnel shape and / or the connecting plate (156); wherein the common port (150) includes an inner portion (152), the inner portion including the inlet port (120) and the outlet port (130); wherein the common port (150) comprises an outer portion (151) which at least partially surrounds the inner portion (152); wherein the common port (150) is configured as a discrete device; The outlet port (130) is arranged at the lowest part of the temperature regulating tank (110), particularly relative to the direction of gravity.

16. The analysis device (100) according to the preceding claim, in, The flow direction of the inlet fluid path (121) and / or the flow direction of the outlet fluid path (131) is substantially vertical, in particular substantially parallel to the direction of gravity.

17. A method for analyzing a sample, the method comprising: Providing the sample to the fluid in the temperature-controlled bath (110); and Temperature control of the tank is provided by: allowing the fluid in the inlet fluid path (121) to flow from the inlet port (120) through the fluid in the temperature regulating tank (110), and Allowing the fluid in the outlet fluid path (131) to flow from the fluid in the temperature regulating tank (110) to the outlet port (130); Wherein, the inlet port (120) and the outlet port (130) are combined into a single common port (150).

18. The method according to claim 17, further comprising: Especially for dissolution testing in healthcare and / or pharmaceutical environments.

19. The method according to claim 17 or 18, further comprising: In particular, the fluid is circulated between the outlet port (130) and the inlet port (120) by means of a heating device (160).

20. Use of a common port (150) having an inlet port (120) and an outlet port (130) for controlling the temperature of a fluid in a thermostatic bath (10) by means of a heating fluid through a single opening of the thermostatic bath (110).

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