Immunoassay analyzer, carrier positioning method and sample diluent mixing method

Abstract

The present application relates to an immunoassay analyzer, including: a transfer component, a sampling component, a reagent storage component, a dilution component and a material extraction component. The material extraction component includes a linear unit, a sampling unit and a reagent extraction unit. Driven by the linear unit, the sampling unit and the reagent extraction unit move in a linear direction; the sampling unit has a plurality of first stop points, and the first stop points are correspondingly located above the functional components on the transfer component, the sample suction port on the sampling component, the outlet on the reagent storage component and the inlet on the dilution component; the reagent extraction unit has a plurality of second stop points, and the second stop points are correspondingly located above the functional components on the transfer component and the outlet on the reagent storage component. The present application also relates to a carrier positioning method and a sample diluent mixing method. The transfer component, the sampling component, the reagent storage component and the dilution component are arranged on the straight path of the sampling unit and the reagent extraction unit, and the transfer efficiency of the sampling unit and the reagent extraction unit is high.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to an immunoassay analyzer, a carrier positioning method, and a sample diluent mixing method. Background Art

[0002] In existing immunoanalyzers, if you want to increase the test throughput and functions of the immunoanalyzer, you need to expand the capacity of the reaction cups and reagents in the immunoanalyzer and reserve installation space. This means that the more complete the functions and the larger the throughput of the detection equipment, the larger the space it occupies. This is undoubtedly a huge challenge for the current demand for portability and miniaturization.

[0003] In addition, as the size of the testing equipment gradually increases, the circulation time of samples and reaction cups in the testing equipment will also be extended. If the testing time remains unchanged, the time required for a single test will increase, thereby affecting the detection efficiency of the testing equipment. Summary of the invention

[0004] In order to solve the above technical problems, this application provides the following technical solutions:

[0005] On the one hand, the present application provides an immunoassay analyzer, comprising:

[0006] A transfer assembly, wherein a plurality of functional components are provided on the transfer assembly;

[0007] A sample injection component, wherein the sample injection component is provided with at least two sample suction ports;

[0008] A reagent storage component, wherein the reagent storage component is provided with a plurality of outlets;

[0009] a dilution assembly having an inlet; and

[0010] The material taking component includes a linear unit, a sampling unit and a reagent taking unit. The sampling unit and the reagent taking unit are installed on the linear unit. When driven by the linear unit, the sampling unit and the reagent taking unit move in a linear direction.

[0011] The sampling unit has a plurality of first stop points, and the first stop points are correspondingly located above the functional components on the transfer component, the sample suction port on the injection component, the outlet on the reagent storage component, and the inlet on the dilution component;

[0012] The reagent taking unit has a plurality of second stopping points, and the second stopping points are correspondingly located above the functional components on the transfer component and the outlet on the reagent storage component.

[0013] In one embodiment, the linear unit has two independent power output ends, and the sampling unit and the reagent taking unit are respectively installed on the two power output ends.

[0014] In one embodiment, the sampling unit and the reagent taking unit move along the same horizontal straight line direction.

[0015] In one embodiment, the reagent storage component, the transfer component, the dilution component, and the injection component are arranged in sequence along a horizontal straight line.

[0016] In one embodiment, the transfer assembly includes a base unit and a carrier unit for loading a reaction cup, the base unit has a guide portion, and driven by an external force, the carrier unit is limited by the guide portion to move laterally or move laterally and longitudinally at the same time, so that the carrier unit moves back and forth between a longitudinal high position and a longitudinal low position.

[0017] In one embodiment, it further includes a reaction cup storage component and an incubation component;

[0018] The reaction cup storage component and the incubation component are located on the longitudinal high side of the transfer component, and the sampling component, the reagent storage component and the dilution component are located on the longitudinal low side of the transfer component, so that the reaction cup storage component and the incubation component are located above the sampling component, the reagent storage component and the dilution component.

[0019] In one embodiment, it also includes a cleaning and measuring component, a waste cup collection component and a mechanical gripper, and a carrier is installed in the reaction cup storage component, and the carrier has a plurality of through holes distributed in an equidistant array;

[0020] The cleaning and measuring component, the reaction cup storage component, the incubation component and the waste cup collection component are located on the same horizontal plane, and the reaction cup grasped by the mechanical gripper flows among the cleaning and measuring component, the reaction cup storage component, the incubation component, the waste cup collection component and the transfer component.

[0021] In one embodiment, the dilution assembly includes at least two dilution cup units, a cleaning tube unit and a rotating unit, and the dilution cup units are symmetrically mounted on the rotating shaft of the rotating unit;

[0022] In the longitudinal direction, the inlet is located above the dilution cup unit, and the cleaning tube unit is located below the dilution cup unit.

[0023] On the other hand, the present application provides a carrier positioning method based on the above-mentioned embodiment of the immunoassay analyzer, comprising: the through holes include P1, P2 and P3, wherein P1 is the first hole, P2 is the last hole in the row where the first hole P1 is located, and P3 is the last hole in the column where the first hole P1 is located;

[0024] Construct a coordinate system based on the confirmed positions P1, P2, and P3;

[0025] The coordinate positions of all through holes in the coordinate system are calculated based on the gap between two adjacent through holes.

[0026] In another aspect, the present application provides a sample dilution mixing method based on the immunoassay analyzer of the above embodiment, comprising:

[0027] S1, the sampling unit extracts the diluent in the reagent storage component and the sample liquid in the injection component;

[0028] S2, the sampling unit moves to the discharge position of the dilution cup unit, and spits all the diluent and sample liquid in the sampling unit into the dilution cup unit;

[0029] S3, the sampling unit sinks to the mixing position of the dilution cup unit, the sampling unit absorbs part of the liquid according to the proportion, and then spits out the liquid;

[0030] S4. The sampling unit is lifted to the discharge position to absorb the air column, and then lowered to the mixing position to absorb the mixed sample.

[0031] This application has at least the following beneficial effects:

[0032] In the present application, by optimizing the layout, the transfer assembly, the injection assembly, the reagent storage assembly and the dilution assembly are arranged on the straight path of the sampling unit, and correspondingly, the transfer assembly and the reagent storage assembly are arranged on the straight path of the reagent extraction unit, which reduces the moving path of the sampling unit and the reagent extraction unit and improves the transfer efficiency of the sampling unit and the reagent extraction unit. At the same time, the components corresponding to the multiple stations of the sampling unit and the reagent extraction unit are arranged on the transfer assembly, the injection assembly, and the reagent storage assembly, making the structure of the immunoassay analyzer more compact.

[0033] When the sample in the existing luminescence analyzer needs to be diluted, the sample and the diluent are extracted and mixed. The extracted sample and the diluent are transferred to the dilution cup for mixing, and the mixed liquid is transferred back to the transfer component after the mixing is completed. In this solution, the dilution component is located on one side of the transfer component, and the shaking position is located under the moving path of the sampling unit, which reduces the transfer time required for the dilution and the sample in the dilution component and back to the transfer component. The sampling unit extracts the dilution and the sample and mixes them in the dilution component. Dilution will not affect the detection speed in the normal test process, and the dilution test does not occupy extra reaction cups for mixing, reducing the use of consumables.

[0034] By moving the stage unit laterally or both laterally and longitudinally, the movement trajectory of the stage unit is made Z-shaped, and the reaction cup is transferred longitudinally; and based on the longitudinal transfer of the reaction cup, the reaction cup storage component and the reagent storage component are designed in an upper and lower layout, which can reduce the footprint of the immunoassay analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 A schematic diagram of the three-dimensional structure of an immunoassay analyzer provided in one embodiment of the present application.

[0036] Figure 2 A schematic diagram of the layout structure of an immunoassay analyzer provided in one embodiment of the present application.

[0037] Figure 3 A schematic diagram of the partial layout of a transfer component, a material collection component, a reagent storage component, and a dilution component provided in one embodiment of the present application.

[0038] Figure 4 A schematic diagram of the partial layout of a transfer assembly, a cleaning and measuring assembly, and a reaction cup storage assembly provided in one embodiment of the present application.

[0039] Figure 5 A schematic diagram of the three-dimensional structure of a transfer mechanism provided in one embodiment of the present application.

[0040] Figure 6 A schematic diagram of the three-dimensional structure of a sample injection assembly provided in one embodiment of the present application.

[0041] Figure 7 A schematic diagram of the three-dimensional structure of the emergency unit in the injection assembly provided in one embodiment of the present application.

[0042] Figure 8 A schematic diagram of the three-dimensional structure of a material taking assembly provided in one embodiment of the present application.

[0043] Fig. 9 A schematic diagram of the three-dimensional structure of a reagent storage assembly provided in one embodiment of the present application.

[0044] Fig.10 A top view of the partial structure of a reagent storage assembly provided in one embodiment of the present application.

[0045] Fig.11 A schematic diagram of the three-dimensional structure of a reagent box holder and a reagent box provided in one embodiment of the present application.

[0046] Fig.12 A cross-sectional view of a reagent box holder and a reagent box provided in one embodiment of the present application.

[0047] Fig.13 A schematic diagram of the three-dimensional structure of a dilution component provided in one embodiment of the present application.

[0048] Fig.14 A schematic diagram of the mixing liquid level of a dilution cup unit provided in one embodiment of the present application.

[0049] Fig.15 A schematic diagram of a through hole on a carrier provided in an embodiment of the present application.

[0050] Fig.16 A simplified diagram of through-hole coordinates when a carrier is relatively tilted provided in an embodiment of the present application.

[0051] Reference numerals:

[0052] 10. Transfer components;

[0053] 11. Base unit; 12. Stage unit; 13. First cleaning unit; 14. Shaking unit; 15. Second cleaning unit;

[0054] 20. Sample injection assembly;

[0055] 21. Sample injection unit; 22. Sample unloading unit; 23. Sample rack; 24. Emergency unit; 25. Scanning unit;

[0056] 241, slide table; 242, pull rod; 243, first detection part; 244, limit part; 245, buffer part; 246, second detection part; 2401, emergency sample;

[0057] 30. Material taking component;

[0058] 31. Linear unit; 32. Sampling unit; 33. Reagent taking unit;

[0059] 321, first lifting motor; 322, sample needle;

[0060] 331. second lifting motor; 332. reagent needle;

[0061] 40. Reagent storage assembly;

[0062] 41. Reagent disk unit; 42. Rotating motor; 43. Refrigeration unit;

[0063] 411. reagent box seat; 412. reagent box; 413. rotating disk;

[0064] 4111, bayonet;

[0065] 4121, buckle convex point;

[0066] 50. Dilution component;

[0067] 51. dilution cup unit; 52. cleaning tube unit; 53. mounting frame;

[0068] 531, rotating shaft; 532, needle hole;

[0069] 60. Clean the measuring components;

[0070] 70. Reaction cup storage assembly;

[0071] 71. Vehicle;

[0072] 711, through hole;

[0073] 80. Incubation component;

[0074] 90. Waste cup collection component;

[0075] 101, sample adding position; 102, sample needle cleaning position; 103, reagent needle cleaning position; 104, reagent adding position; 105, reaction cup position;

[0076] 201, general sample suction position; 202, emergency sample suction position;

[0077] 401, diluent suction position; 402, first reagent suction position; 403, second reagent suction position; 404, magnetic bead suction position;

[0078] 501. Mixed bit. DETAILED DESCRIPTION

[0079] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0080] In the description of the present application, it should be understood that if the terms "length", "width", "thickness", "up", "down", "vertical", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0081] In addition, if the terms "first", "second", and "third" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first", "second", and "third" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0082] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0083] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0084] It should be noted that if an element is referred to as being "fixed to" or "disposed on" or "set on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only implementation method.

[0085] The embodiments of the present application are described in detail below with reference to the accompanying drawings.

[0086] Reference Figure 1-3As shown, in some embodiments of the present application, the present application provides an immunoassay analyzer, including: a transfer component 10, a sampling component 20, a material collection component 30, a reagent storage component 40 and a dilution component 50. The material collection component 30 includes a linear unit 31, a sampling unit 32 and a reagent collection unit 33. The linear unit 31 drives the sampling unit 32 and the reagent collection unit 33 to move along a straight line direction X. When the sampling unit 32 moves along the straight line direction X, the sampling unit 32 has a plurality of first stop points; correspondingly, when the reagent collection unit 33 moves along the straight line direction X, the reagent collection unit 33 has a plurality of second stop points. In the present solution, the linear unit 31 has two independent power output ends, and the sampling unit 32 and the reagent collection unit 33 are respectively installed on the two power output ends. The sampling unit 32 and the reagent collection unit 33 can independently translate along the straight line direction X. Exemplarily, in combination with Figure 8 As shown, the linear unit 31 includes two linear drivers and a bracket, and the two linear drivers have the above-mentioned two independent power output ends, and the linear drivers are respectively installed on both sides of the bracket, so that the sampling unit 32 and the reagent unit 33 can move in parallel along the linear direction X. The sampling unit 32 and the reagent unit 33 move in parallel along the linear direction X, which reduces the moving path of the sampling unit 32 and the reagent unit 33 and improves the transfer efficiency of the sampling unit 32 and the reagent unit 33. Exemplarily, the linear direction X is a horizontal linear direction. However, it should be pointed out that the sampling unit 32 and the reagent unit 33 in the present application include but are not limited to moving along the same horizontal linear direction, and the sampling unit 32 and the reagent unit 33 in the present application can also move in different linear directions, and the moving directions of the sampling unit 32 and the reagent unit 33 can also be inclined relative to the horizontal plane.

[0087] Specifically, the first stop position includes a plurality of sampling unit 32 stop positions such as a sample adding position 101, a normal sample suction position 201, an emergency sample suction position 202, a diluent suction position 401 and a mixing position 501. The second stop position includes a plurality of reagent taking unit 33 stop positions such as a reagent needle cleaning position 103, a reagent adding position 104, a first reagent suction position 402, a second reagent suction position 403 and a magnetic bead suction position 404. The sampling unit 32 includes a sample needle 322 and a first lifting motor 321, the sample needle 322 is installed on the first lifting motor 321, and the sample needle 322 can be driven by the first lifting motor 321, so that the sample needle 322 can be close to the sample injection component 20, the transfer component 10, the dilution component 50 and the reagent storage component 40. In addition, the reagent taking unit 33 includes a second lifting motor 331 and a reagent needle 332, and the reagent needle 332 can be driven by the second lifting motor 331, so that the reagent needle 332 can be close to the transfer component 10 and the reagent storage component 40.

[0088] Combination Figure 5As shown, the transfer assembly 10 is provided with a plurality of functional components to correspond to the sample adding position 101, the sample needle cleaning position 102, the reagent needle cleaning position 103, and the reagent adding position 104. The transfer assembly 10 includes a base unit 11, a stage unit 12, and a plurality of functional components. The base unit 11 is slidably connected with the stage unit 12, and a plurality of functional components are installed on the base unit 11. The functional components include a first cleaning unit 13, a shaking unit 14, and a second cleaning unit 15, and the first cleaning unit 13, the shaking unit 14, and the second cleaning unit 15 are arranged corresponding to the sample needle cleaning position 102, the reagent adding position 104, and the reagent needle cleaning position 103. It should be pointed out that a point position in the moving path of the stage unit 12 corresponds to the sample adding position 101. When the stage unit 12 and the sampling unit 32 move to the point position at the same time, the sampling unit 32 performs the sample adding process on the reaction cup on the stage unit 12 at the point position.

[0089] The sample injection assembly 20 is provided with two sample suction ports, corresponding to the common sample suction position 201 and the emergency sample suction position 202. The sample injection assembly 20 is used to transfer samples. Figure 6 As shown, the sample injection assembly 20 includes a sample injection unit 21, a sample unloading unit 22 and an emergency unit 24. A sample rack 23 is transferred between the sample injection unit 21 and the sample unloading unit 22. A plurality of samples can be loaded on the sample rack 23. The sample rack 23 is transferred from the sample injection unit 21 to the sample unloading unit 22. There is a gap between the sample injection unit 21 and the sample unloading unit 22, wherein a sample suction port is arranged in the gap. When the sample rack 23 passes through the gap, the sampling unit 32 moves to the sample suction port to extract the sample. Another sample suction port is arranged on the emergency unit 24, and the sampling unit 32 can also move to the sample suction port of the emergency unit 24 to extract the sample, thereby realizing the emergency function. Exemplarily, the emergency unit 24 is located in the gap between the sample injection unit 21 and the sample unloading unit 22, and the sample suction port on the emergency unit 24 and another sample suction port are located in the straight line direction X.

[0090] The reagent storage assembly 40 is provided with a plurality of outlets corresponding to the diluent suction position 401, the first reagent suction position 402, the second reagent suction position 403, and the magnetic bead suction position 404. The reagent storage assembly 40 includes a reagent disk unit 41 and a rotating motor 42. The reagent disk unit 41 is loaded with a plurality of reagent kits. The rotating motor 42 can drive the reagent kits in the reagent disk unit 41 to rotate. The outer shell of the reagent disk unit 41 is provided with a plurality of outlets. The reagent kits correspond to the outlets. The sampling unit 32 and the reagent extraction unit 33 can extract reagents from the reagent kits through the outlets.

[0091] The dilution assembly 50 has an inlet corresponding to the mixing position 501. Fig.13As shown, the dilution assembly 50 includes a dilution cup unit 51, a cleaning tube unit 52 and a mounting frame 53. The number of the dilution cup units 51 is at least two. The plurality of dilution cup units 51 are accommodated in the mounting frame 53. A needle hole 532 serving as an inlet is provided at the top of the mounting frame 53. A rotating shaft 531 is also installed on the mounting frame 53. The plurality of dilution cup units 51 are connected to the rotating shaft 531. The dilution cup unit 51 is located below the needle hole 532, and the cleaning tube unit 52 is located below the dilution cup unit 51. The plurality of dilution cup units 51 can rotate to correspond to the needle hole 532 or the cleaning tube unit 52. When the dilution cup unit 51 corresponds to the needle hole 532, the sample and the diluent can be mixed in the dilution cup unit 51. When the dilution cup unit 51 corresponds to the cleaning tube unit 52, the cleaning tube unit 52 can clean the dilution cup unit 51.

[0092] refer to Fig.14 As shown, the dilution cup unit 51 has a liquid discharge position, a mixing position and a maximum limit position, which are arranged in sequence from the opening to the bottom of the cup. Among them, the liquid discharge position is a position higher than the maximum dilution and mixing liquid level, generally set near the 600uL liquid level.

[0093] The method of mixing the sample and the diluent in the dilution component 50 comprises:

[0094] S1, the sample needle 322 absorbs the diluent in the reagent storage component 40 and the sample liquid in the injection component 20, and the sample in the injection component 20 can be a common sample or an emergency sample 2401;

[0095] S2, running to the liquid discharge position of the dilution cup unit 51, and quickly spitting the diluent and sample liquid sucked by the sample needle 322 into the dilution cup unit 51;

[0096] S3, the sample needle 322 moves to the mixing position, absorbs part of the total liquid volume of this dilution according to the proportion, and then spits out the liquid to achieve the purpose of mixing the sample. The absorption ratio is preferably half of the total liquid volume of this dilution;

[0097] S4, the sample needle 322 is lifted up again and moves to the liquid discharge position to absorb the air column above, and then moves to the mixing position to absorb and mix the sample.

[0098] Furthermore, the reagent storage component 40, the transfer component 10, the dilution component 50, and the injection component 20 are arranged in sequence along the straight line direction X. Figure 4As shown, the immunoassay analyzer also includes a cleaning and measuring component 60, a reaction cup storage component 70, an incubation component 80, a waste cup collection component 90 and a mechanical gripper component. The cleaning and measuring component 60 is arranged close to the incubation component 80. In the longitudinal direction Z, the reaction cup storage component 70 and the reagent storage component 40 are arranged up and down, that is, the cleaning and measuring component 60, the reaction cup storage component 70, the incubation component 80, and the waste cup collection component 90 are located above the reagent storage component 40. Among them, the cleaning and measuring component 60 is used for magnetic separation and cleaning of the reaction liquid, filling of the excitation liquid and optical signal measurement. The incubation component 80 is used to provide the temperature environment required for the reaction of the sample and the reagent. After the reaction of the sample and the reagent, it can be transferred to the cleaning and measuring component 60 as soon as possible. After the test is completed, the reaction cup containing the waste liquid is sent to the waste cup collection component 90. The movement range of the mechanical gripper assembly covers the reaction cup storage assembly 70, the longitudinal high position of the stage unit 12, the incubation assembly 80, the cleaning and measuring assembly 60, and the waste cup collection assembly 90, and the automatic circulation of the reaction cup is realized through the mechanical gripper assembly.

[0099] The transfer assembly 10 includes a base unit 11 and a stage unit 12 for loading a reaction cup. The base unit 11 has a guide portion. Driven by an external force, the stage unit 12 is limited by the guide portion to move in the lateral Y direction or in the lateral Y and longitudinal Z directions at the same time. The movement trajectory of the stage unit 12 is Z-shaped. The stage unit 12 can be in a longitudinal high position and a longitudinal low position. In the longitudinal Z direction, the height of the longitudinal high position is greater than the height of the longitudinal low position.

[0100] The vertical high position of the stage unit 12 is located on the same horizontal plane as the cleaning and measuring assembly 60, the cup storage assembly 70, the incubation assembly 80 and the waste cup collection assembly 90. The vertical low position of the stage unit 12 is located on the same horizontal plane as the injection assembly 20, the reagent storage assembly 40 and the dilution assembly 50, so that the cleaning and measuring assembly 60, the cup storage assembly 70, the incubation assembly 80 and the waste cup collection assembly 90 are arranged up and down with the injection assembly 20, the reagent storage assembly 40 and the dilution assembly 50.

[0101] In the scheme, the stage unit 12 can move back and forth between the reagent storage assembly 40 and the reaction cup storage assembly 70. The operating range of the mechanical gripper covers the cleaning and measuring assembly 60, the reaction cup storage assembly 70, the incubation assembly 80, the waste cup collection assembly 90 and the longitudinal high position of the stage unit 12. The arrangement of the reagent storage assembly 40, the transfer assembly 10, the dilution assembly 50, the injection assembly 20 and the reaction cup storage assembly 70 can make the immunoassay analyzer more compact. In addition, since the longitudinal high positions of the cleaning and measuring assembly 60, the reaction cup storage assembly 70 and the stage unit 12 are close to each other, the longitudinal high position of the stage unit 12 and the cleaning and measuring assembly 60 are located on the circumferential outer side of the reaction cup storage assembly 70, the time consumed by the mechanical gripper to complete a single reaction cup transfer is short, which can effectively improve the throughput of the reaction cup.

[0102] The cuvette storage assembly 70 has a cavity for accommodating the carrier 71, and the incubation assembly 80 is located on one side of the cuvette storage assembly 70. A plurality of through holes 711 are arranged in an array on the carrier 71, and the gap L between two adjacent through holes 711 is kept consistent, so that the cuvette can be placed in the through holes 711. In a specific embodiment, a method for positioning the through holes 711 on the carrier 71 in the accommodating unit includes: forming a coordinate system through the positions of the through holes P1, the through holes P2, and the through holes P3; and calculating the coordinate positions of all the through holes 711 according to the gaps between the through holes 711.

[0103] During use, the mechanical gripper and the carrier 71 may be relatively tilted due to installation reasons. Fig.16 The positioning calculation formula based on the through hole 711 on the tilting carrier 71 includes:

[0104] (1) Calculate the unit vector

[0105] ;

[0106] (2) Calculate the coordinates of the nth through hole

[0107]

[0108] Among them, the nth through hole is located in the ath n Row, b n List;

[0109] ;

[0110] From this, the coordinates of the nth through hole can be obtained as:

[0111] ;

[0112] Right now

[0113] Through the above calculation formula, the coordinates of the nth through hole can be calculated, and then the actual coordinates of all through holes 711 can be calculated, so that the mechanical gripper can grab the reaction cup in the through hole 711.

[0114] In some embodiments of the present application, reference Figure 7As shown, the emergency unit 24 includes a slide 241 and a pull rod 242, wherein the slide 241 and the pull rod 242 are slidably connected, and the pull rod 242 can slide relative to the slide 241 to the detection position. The pull rod 242 has a loading hole for loading the emergency sample 2401. A first detection portion 243 and a second detection portion 246 are fixedly connected to the slide 241, wherein when the pull rod 242 moves to the detection position, the first detection portion 243 is used to detect whether the emergency sample 2401 is loaded on the pull rod 242. The second detection portion 246 is used to detect whether the pull rod 242 moves to the detection position. A limiting portion 244 is installed on the pull rod 242, and when the pull rod 242 moves to the detection position, the limiting portion 244 can be connected to the slide 241 to limit the relative movement of the pull rod 242 and the slide 241.

[0115] Exemplarily, the limiter 244 is an electromagnet. When the pull rod 242 moves to the detection position, the electromagnet generates magnetism, and the electromagnet and the slide 241 generate a strong suction force, so that the positions of the pull rod 242 and the slide 241 are relatively fixed. In this solution, the pull rod 242 is locked by the electromagnet to avoid accidental risks caused by human error.

[0116] In this solution, the emergency unit 24 also includes an external indicator light, which is electrically connected to the second detection unit 246. When the user pulls out the pull rod 242, the external indicator light goes out, and the pull rod 242 moves to the detection position. The external indicator light turns on and off to prompt the user whether the pull rod 242 is pushed in place.

[0117] Furthermore, the slide 241 is also provided with a buffer portion 245, and when the pull rod 242 moves to the detection position, the pull rod 242 interacts with the buffer portion 245. Exemplarily, the buffer portion 245 is a permanent magnet with weak magnetism, and the pull rod 242 is made of metal material. When the pull rod 242 approaches the detection position, the pull rod 242 is attracted by the permanent magnet, so that the pull rod 242 slowly returns to the detection position.

[0118] Furthermore, if Figure 6 As shown, the sample injection assembly 20 further includes a scanning unit 25, which is located between the sample injection unit 21 and the sample unloading unit 22. The scanning unit 25 can identify the information of the common samples on the sample rack 23 between the sample injection unit 21 and the sample unloading unit 22, and the information of the emergency sample 2401 on the emergency unit 24.

[0119] In some embodiments of the present application, reference Figure 9-12 As shown, the reagent disk unit 41 includes a body and a rotating disk 413, and the rotating motor 42 drives the rotating disk 413 to rotate relative to the body. A plurality of reagent kit subsets are installed on the rotating disk 413, and the reagent kit subsets include a reagent kit seat 411 and a plurality of reagent kits 412, and the reagent kits 412 are clamped in the reagent kit seat 411, and the outlet is opened on the body.

[0120] Specifically, a bayonet 4111 is provided on the reagent box seat 411, and a buckle protrusion 4121 is also provided on the reagent box 412. The bayonet 4111 cooperates with the buckle protrusion 4121 so that the reagent box 412 is installed on the reagent box seat 411 to limit the relative position of the reagent box 412 and the reagent box seat 411.

[0121] Further, a plurality of reagent kit seats 411 are evenly distributed on the rotating disk 413. Exemplarily, the plurality of reagent kit seats 411 are radially distributed on the rotating disk 413. The reagent kit seats 411 are set at an angle, and the angle of the reagent kit seats 411 is set so that the arrangement direction of the reagent kit seats 411 is inclined relative to the radial direction of the rotating disk 413. Among them, a plurality of reagent kit seats 411 can be arranged in the reagent kit seat 411, and the plurality of reagent kit seats 411 are arranged in a straight line direction, and the arrangement direction of the plurality of reagent kit seats 411 is the arrangement direction of the reagent kit seats 411. The arrangement direction of the reagent kit seats 411 forms an angle with the radial direction of the rotating disk 413 as shown in FIG. Fig.10 The angle α is shown.

[0122] By setting the reagent kit seat 411 at an angle, the utilization rate of the plane space of the rotating disk 413 is improved, and the capacity of the reagent kit 412 on the rotating disk 413 is increased.

[0123] Furthermore, the reagent storage assembly 40 further includes a refrigeration unit 43, which is disposed near the reagent disk unit 41. In this embodiment, the refrigeration unit 43 is disposed below the reagent disk unit 41. The refrigeration unit 43 maintains a frozen environment inside the reagent disk unit 41, thereby increasing the validity period of the reagent inside.

[0124] The above embodiments are used to further illustrate the present application, but the present application is not limited to these specific implementations. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be understood to be within the scope of protection of the present application.

Claims

1. An immunoassay analyzer, characterized in that: include: A transfer assembly (10), wherein the transfer assembly (10) is provided with a plurality of functional components, wherein the functional components include a first cleaning unit (13), a shaking unit (14) and a second cleaning unit (15); the transfer assembly (10) includes a base unit (11) and a carrier unit (12) for loading a reaction cup; the base unit (11) is provided with a guide portion; under the drive of an external force, the carrier unit (12) is limited by the guide portion to move laterally or move laterally and longitudinally at the same time, so that the carrier unit (12) moves back and forth between a longitudinal high position and a longitudinal low position; A sample injection assembly (20), wherein the sample injection assembly (20) is provided with at least two sample suction ports; A reagent storage component (40), wherein the reagent storage component (40) is provided with a plurality of outlets for diluents, reagents, and magnetic beads to pass through; a dilution assembly (50) having an inlet for passage of a diluent and a sample; and A material taking component (30), the material taking component (30) comprising a linear unit (31), a sampling unit (32) and a reagent taking unit (33), the sampling unit (32) and the reagent taking unit (33) being mounted on the linear unit (31), and under the drive of the linear unit (31), the sampling unit (32) and the reagent taking unit (33) move in a linear direction; The sampling unit (32) has a plurality of first parking points, wherein the first parking points are correspondingly located above the functional components on the transfer component (10), the sample suction port on the injection component (20), the outlet on the reagent storage component (40) and the inlet on the dilution component (50); The reagent taking unit (33) has a plurality of second parking points, and the second parking points are correspondingly located above the functional components on the transfer component (10) and the outlet on the reagent storage component (40); The immunoassay analyzer further comprises a reaction cup storage component (70) and an incubation component (80); The reaction cup storage component (70) and the incubation component (80) are located on the longitudinal high side of the transfer component (10), and the sample injection component (20), the reagent storage component (40) and the dilution component (50) are located on the longitudinal low side of the transfer component (10), so that the reaction cup storage component (70) and the incubation component (80) are located above the sample injection component (20), the reagent storage component (40) and the dilution component (50).

2. The immunoassay analyzer according to claim 1, characterized in that: The linear unit (31) has two independent power output ends, and the sampling unit (32) and the reagent taking unit (33) are respectively installed on the two power output ends.

3. The immunoassay analyzer according to claim 2, characterized in that: The sampling unit (32) and the reagent taking unit (33) move along the same horizontal straight line direction.

4. The immunoassay analyzer according to claim 3, characterized in that: The reagent storage component (40), the transfer component (10), the dilution component (50), and the sample injection component (20) are arranged in sequence along the horizontal straight line direction.

5. The immunoassay analyzer according to claim 1, characterized in that: It also includes a cleaning and measuring component (60), a waste cup collecting component (90) and a mechanical gripper. The reaction cup storage component (70) is equipped with a carrier (71), and the carrier (71) has a plurality of through holes (711) distributed in an equidistant array. The cleaning and measuring component (60), the reaction cup storage component (70), the incubation component (80) and the waste cup collection component (90) are located on the same horizontal plane, and the reaction cup grasped by the mechanical gripper flows among the cleaning and measuring component (60), the reaction cup storage component (70), the incubation component (80), the waste cup collection component (90) and the transfer component (10).

6. The immunoassay analyzer according to any one of claims 1 to 5, characterized in that: The dilution assembly (50) comprises at least two dilution cup units (51), a cleaning tube unit and a rotating unit, wherein the dilution cup unit (51) is symmetrically mounted on a rotating shaft of the rotating unit; In the longitudinal direction, the inlet is located above the dilution cup unit (51), and the cleaning pipe unit is located below the dilution cup unit (51).

7. The carrier positioning method of the immunoassay analyzer according to claim 5, characterized in that: include: The through holes (711) include P1, P2 and P3, wherein P1 is the first hole, P2 is the last hole in the row where the first hole P1 is located, and P3 is the last hole in the column where the first hole P1 is located; Construct a coordinate system based on the confirmed positions P1, P2, and P3; The coordinate positions of all through holes (711) in the coordinate system are calculated according to the gap between two adjacent through holes (711).

8. The sample diluent mixing method based on the immunoassay analyzer according to claim 6, characterized in that: include: S1, the sampling unit (32) extracts the diluent in the reagent storage component (40) and the sample liquid in the injection component (20); S2, the sampling unit (32) moves to the liquid discharge position of the dilution cup unit (51), and discharges all the diluent and sample liquid in the sampling unit (32) into the dilution cup unit (51); S3, the sampling unit (32) sinks to the mixing position of the dilution cup unit (51), the sampling unit (32) absorbs part of the liquid according to the proportion, and then spits out the liquid; S4, the sampling unit (32) is lifted to the liquid discharge position to absorb the air column, and then lowered to the mixing position to absorb the mixed sample.

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