Lumbricus protein peptide composition for improving microcirculation disturbance and preparation process thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine health care products, and discloses an earthworm protein peptide composition for improving microcirculation disturbance, which comprises the following components in parts by weight: 20-50 parts of earthworm protein peptide, 5-20 parts of red yeast rice extract, 1-5 parts of natto powder and 6-16 parts of small molecular collagen peptide, 5 to 10 parts of spirulina platensis, and 1.5 to 4 parts of y-aminobutyric acid; the preparation process comprises the following steps: S1, preparing raw materials: preparing earthworm protein peptide powder, red yeast rice extract powder, natto powder and spirulina platensis powder for later use; s2, proportioning and mixing: accurately weighing the components of the raw materials prepared in the S1 according to proportioning requirements, and uniformly mixing; s3, quality detection and packaging; s4, storing and transporting; according to the scheme, the six effective components cooperate with one another, and microcirculation can be effectively improved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine health care products, in particular to an earthworm protein peptide composition for improving microcirculation disorders and a preparation process thereof. Background Art

[0002] Microcirculatory disorder is a common pathological phenomenon, which refers to the poor or blocked blood circulation in micro-vessels (such as capillaries, arterioles and venules), which results in insufficient oxygen and nutrients for tissues and organs, and the inability to excrete metabolic waste in a timely manner. This disorder may cause a variety of diseases, such as cardiovascular and cerebrovascular diseases, diabetic foot, varicose veins, etc., seriously affecting people's health and quality of life.

[0003] In the field of traditional Chinese medicine health care products, finding safe and effective methods to improve microcirculation has always been a hot topic of research. In traditional Chinese medicine, many natural plant and animal ingredients have been proven to have the effect of improving microcirculation, but these ingredients often have problems such as unclear active ingredients and unstable effects. Therefore, it is of great significance to develop a health care product that improves microcirculation with clear active ingredients, significant effects and high safety.

[0004] In recent years, with the continuous development of biotechnology, it has become a trend to extract active ingredients from natural plants and animals and prepare them into health products. Ingredients such as earthworm protein peptides, red yeast rice extract, natto powder, small molecule collagen peptides, Spirulina platensis, and γ-aminobutyric acid have attracted much attention due to their unique biological activities and health functions. These ingredients have significant effects in improving microcirculation, regulating blood lipids, and enhancing immunity, and are highly safe and suitable for long-term use.

[0005] However, a single ingredient is often unable to meet the comprehensive needs of improving microcirculation. Therefore, scientifically matching and combining multiple active ingredients to exert their synergistic effects becomes the key to improving the effectiveness of health care products. Summary of the invention

[0006] The purpose of the present invention is to provide a composition of earthworm protein peptide for improving microcirculatory disorders and a preparation process thereof, so as to solve the problems existing in the prior art. The present invention uses earthworm protein peptide as a core component, has excellent biological activity, can effectively promote blood flow, reduce vascular resistance, and thus significantly improve microcirculation. The synergistic effect with other components makes the composition perform well in improving microcirculation.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] A lumbar protein peptide composition for improving microcirculatory disorders comprises the following components in parts by weight: 20-50 parts of lumbar protein peptide, 5-20 parts of red yeast rice extract, 1-5 parts of natto powder, 6-16 parts of small molecule collagen peptide, 5-10 parts of spirulina platensis and 1.5-4 parts of y-aminobutyric acid.

[0009] In order to further optimize the present invention, the following technical solutions may be preferably used:

[0010] Preferably, the following components are included in weight: 25-45 parts of earthworm protein peptide, 8-10 parts of red yeast rice extract, 2-3 parts of natto powder, 15-20 parts of small molecule collagen peptide, 6-8 parts of Spirulina platensis, and 2-3 parts of y-aminobutyric acid.

[0011] Preferably, the following components are included in weight: 25 parts of earthworm protein peptide, 8 parts of red yeast rice extract, 2 parts of natto powder, 15 parts of small molecule collagen peptide, 6 parts of Spirulina platensis, and 1.5 parts of y-aminobutyric acid.

[0012] Preferably, the following components are included in weight: 50 parts of earthworm protein peptide, 20 parts of red yeast rice extract, 5 parts of natto powder, 25 parts of small molecule collagen peptide, 10 parts of Spirulina platensis, and 4 parts of y-aminobutyric acid.

[0013] A method for preparing a lumbar protein peptide composition for improving microcirculatory disorders comprises the following steps:

[0014] S1. Raw material preparation

[0015] Prepare earthworm protein peptide powder, red yeast rice extract powder, natto powder, and Spirulina platensis powder for later use;

[0016] S2: Proportioning and mixing

[0017] The raw materials prepared in S1 are mixed according to the following weight ratios: 20-50 parts of earthworm protein peptide, 5-20 parts of red yeast rice extract, 1-5 parts of natto powder, 10-25 parts of small molecule collagen peptide and 5-10 parts of Spirulina platensis. Each component is accurately weighed according to the ratio requirements and mixed evenly.

[0018] S3: Quality Inspection and Packaging

[0019] Quality testing: Conduct quality testing on the mixed composition, including purity, content, biological activity and other indicators to ensure that the product quality meets relevant standards and requirements; Packaging: Use packaging materials with good sealing properties to prevent moisture, oxidation and contamination. During the packaging process, attention should be paid to maintaining environmental hygiene to avoid secondary contamination;

[0020] S4: Storage and Transportation

[0021] Store the packaged composition in a cool, dry place away from light and high temperature. During transportation, care should be taken to maintain the stability and safety of the product and avoid moisture, heat or other physical damage.

[0022] Preferably, the preparation of earthworm protein peptide in step S1 comprises the following steps:

[0023] Raw material selection: Choose fresh earthworms that are free of pests and diseases and impurities as raw materials;

[0024] Cleaning and drying: Clean the earthworms with clean water to remove mud, impurities and internal organs, and then dry them;

[0025] Enzymatic extraction: Add the washed and dried earthworms into an appropriate amount of enzymatic solution, and perform enzymatic treatment under appropriate temperature and pH conditions to obtain earthworm protein peptide extract;

[0026] Separation and purification: The extract is separated and purified by ultrafiltration, nanofiltration, ion exchange and other methods to obtain high-purity earthworm protein peptides;

[0027] Concentration and drying: The purified earthworm protein peptide solution is concentrated and dried to obtain the desired earthworm protein peptide powder.

[0028] Preferably, the preparation of red yeast rice extract in step S1 comprises the following steps:

[0029] Raw material selection: Choose high-quality indica rice, japonica rice or glutinous rice as raw materials;

[0030] Fermentation extraction: The raw materials are fermented with Monascus to obtain red yeast rice extract;

[0031] Purification and drying: The extract is purified to remove impurities and then dried to obtain red yeast rice extract powder.

[0032] Preferably, the preparation of natto powder in step S1 comprises the following steps:

[0033] Raw material selection: Choose high-quality soybeans as raw materials;

[0034] Soaking and steaming: Soak the soybeans for about 12 hours, then wash and steam them thoroughly;

[0035] Fermentation: spray the natto bacteria while it is still hot to ferment and obtain natto;

[0036] Drying and powdering: Put the fermented natto on a drying rack and dry it at about 40 degrees for 24 hours, then use a powdering machine to grind it into powder to obtain natto powder.

[0037] Preferably, the preparation of small molecule collagen peptides in step S1 comprises the following steps:

[0038] Raw material selection: Choose high-quality animal skins, bones, etc. as raw materials;

[0039] Enzymatic extraction: hydrolyzed into small molecule collagen peptides under the catalysis of biological enzymes;

[0040] Separation and purification: Control the distribution of molecular weight through membrane filtration and other methods to obtain small molecule collagen peptides with higher purity.

[0041] Preferably, the preparation of Spirulina platensis in step S1 comprises the following steps:

[0042] Raw material selection: Choose high-quality Spirulina platensis as raw material;

[0043] Extraction: soak the spirulina powder in ethanol to defatted, then extract with water to obtain spirulina extract;

[0044] Purification and drying: the extract is purified to remove impurities, and then dried to obtain Spirulina platensis powder.

[0045] Preferably, the preparation of γ-aminobutyric acid in step S1 comprises the following steps:

[0046] Fermentation production: Through the microbial fermentation method, high-yield strains are selected for pre-culture, and then inoculated into the fermentation matrix containing suitable nutrients for fermentation.

[0047] Separation, extraction and purification: The fermentation broth is separated by centrifugation, filtrate and concentration, and then the γ-aminobutyric acid is purified by cooling crystallization, solvent crystallization and other methods.

[0048] The beneficial effects of the earthworm protein peptide composition for improving microcirculatory disorders are as follows:

[0049] The earthworm protein peptide composition for improving microcirculatory disorders of the present invention has shown remarkable beneficial effects by carefully selecting and scientifically proportioning six effective ingredients, namely earthworm protein peptide, red yeast rice extract, natto powder, small molecule collagen peptide, Spirulina platensis and γ-aminobutyric acid:

[0050] (1) Significantly improve microcirculation: As the core ingredient, earthworm protein peptide has excellent biological activity, which can effectively promote blood flow and reduce vascular resistance, thereby significantly improving microcirculation. The synergistic effect with other ingredients makes the composition perform well in improving microcirculation.

[0051] (2) Regulating blood lipids and blood pressure: Red yeast rice extract is rich in a variety of active ingredients, such as lovastatin, which helps regulate blood lipid levels, lower cholesterol, and thus have a positive impact on blood pressure. Ingredients such as nattokinase in natto powder also have thrombolytic and anticoagulant effects, which help maintain cardiovascular health.

[0052] (3) Enhance immunity and anti-oxidation: Spirulina platensis is rich in vitamins, minerals, and antioxidants, which can enhance human immunity and resist damage from free radicals. Small molecule collagen peptides help maintain the health of skin, bones and other tissues, further promoting overall health.

[0053] (4) Promote sleep and nerve regulation: GABA, as a precursor of neurotransmitters, has sedative and hypnotic effects, can improve sleep quality and regulate nervous system function. This is also of great significance for improving microcirculation, because good sleep and nerve state help the body recover and repair.

[0054] (5) Safe, effective and easy to absorb: The composition of the present invention adopts a scientific preparation process to ensure that the effective ingredients of each component are fully retained and easily absorbed by the human body. At the same time, the synergistic effect between the components makes the composition have a significant effect in improving microcirculation, and it is highly safe and suitable for long-term use.

[0055] In summary, the earthworm protein peptide composition for improving microcirculation disorders of the present invention has significant beneficial effects. It can not only effectively improve microcirculation, but also regulate blood lipids and blood pressure, enhance immunity and anti-oxidation, promote sleep and nerve regulation, etc. It is safe, effective and easy to absorb, providing a new treatment option for patients with microcirculation disorders. DETAILED DESCRIPTION

[0056] The preferred embodiments of the present invention will be described in detail below. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0057] After the blood of the human body is pumped out by the heart, it flows through the aorta, arterioles, arterioles, and then into the capillaries, and then returns to the heart through the venules and veins at all levels. This blood circulation between the arterioles and venules is called microcirculation. Modern medicine has proved that human aging, hypertension, diabetes, and many cardiovascular and cerebrovascular diseases are closely related to microcirculation. Therefore, whether the function of microcirculation is normal or not is an important indicator of the health status of the human body. Because of this important physiological function, microcirculation is called the "second heart" of the human body by the current medical community. Microcirculation disorders are common in middle-aged and elderly people. When microcirculation is impaired, the blood vessels of the microcirculation are deformed and blocked in the blood vessels, which can cause ischemia, hypoxic necrosis or lesions of organs, tissues, and cells. Microcirculation disorders are the source of all diseases. If the microcirculation is unobstructed, all diseases will not occur. When microcirculation disorders occur in the nervous system, brain cells cannot get enough nutrition and oxygen. At the same time, cellular metabolic products cannot be completely excreted from the body due to insufficient blood supply, which can lead to headaches, dizziness, insomnia, nightmares, and memory loss. In severe cases, stroke, hemiplegia, senile dementia, sciatica, peripheral neuritis, etc. may occur.

[0058] When microcirculation disorder occurs in the cardiovascular system, heart cells are undernourished and myocardium is deprived of oxygen, which leads to chest tightness, palpitations, angina pectoris, irregular heartbeats, and in severe cases, myocardial infarction. Long-term micro-arteriolar contraction leads to hypertension and coronary heart disease. When microcirculation disorder occurs in the respiratory system, chest tightness, shortness of breath, cough, asthma, bronchitis, etc. will occur.

[0059] A terrestris protein peptide composition for improving microcirculatory disorders, comprising the following ingredients: terrestris protein peptide, red yeast rice extract, natto powder, small molecule collagen peptide, and Spirulina platensis;

[0060] Effects of earth dragon protein peptides: (1) Improve microcirculation. Earth dragon protein contains a variety of enzymes, nucleic acids, trace elements and other components. It has a small molecular weight and is a short-chain small molecule. It can smoothly enter the microvessels, dissolve the microthrombi in the microvessels, and restore the elasticity of the hardened microvessels, thereby relieving the blockage and distortion of the microvessels. (2) Dissolve blood clots. Earth dragon protein is rich in fibrinolytic enzymes, which can activate the fibrinolytic enzyme element in the blood clots and convert it into active fibrinolytic enzymes, which then dissolve the fibrin in the blood clots and dissolve fresh blood clots. The fibrinolytic enzymes in earth dragon protein can also directly dissolve blood clots and dissolve old blood clots. (3) Prevent stroke. It has been verified that earth dragon protein has a good rehabilitation function for stroke patients, can clear the brain microcirculation through the blood-brain barrier, and contains hundreds of substances that have a function in repairing and regenerating brain nerves and 7 amino acids that cannot be synthesized by the human body. (4) Lowering blood sugar, blood pressure, and blood lipids. Earthworm protein improves blood vessel perivascular status by restoring blood elasticity, dilating blood vessels, dissolving blood clots, and improving microcirculation, thereby reducing blood flow peripheral resistance and blood viscosity, and has a stable antihypertensive effect, promoting the recovery of pancreatic islet function and having a certain hypoglycemic effect. (5) Enhancing immunity. Earthworm peptide can promote the production of immune lymphocytes and enhance the phagocytic function of macrophages, thereby improving the body's immunity.

[0061] The role of natto powder: Natto powder is a nutritious food made from natto as the main raw material. It has the effects of moisturizing the intestines, promoting digestion, and improving blood lipids.

[0062] The functions of small molecule collagen peptides include: (1) restoring vascular elasticity and preventing blood vessel blockage; (2) delaying aging; (3) improving the tissue structure and absorption function of the small intestine; (4) reducing pain in patients with osteoarthritis such as the knee or hip joints, enhancing bone density, maintaining bone metabolism balance, and preventing osteoporosis; (5) anti-oxidation, anti-fatigue, and eliminating free radicals.

[0063] Among them, the role of red yeast rice extract, current medical research believes that red yeast rice has a very good lipid-lowering effect, whether it is triglycerides or elevated cholesterol, red yeast rice has a very good lipid-lowering effect. It has a good preventive and therapeutic effect on diseases such as hyperlipidemia, arteriosclerosis, and fatty liver.

[0064] The effects of Spirulina platensis include: (1) enhancing the oxygen-carrying capacity of red blood cells; (2) solving cellular and brain hypoxia; (3) improving immunity and improving hyperlipidemia; and (4) treating diabetes, malnutrition, and physical weakness after illness.

[0065] The role of γ-aminobutyric acid: γ-aminobutyric acid is an inhibitory neurotransmitter with multiple physiological effects such as anticonvulsant and hypotensive. It is currently used in the clinic to treat a variety of diseases. As an inhibitory neurotransmitter, γ-aminobutyric acid can inhibit the activity of animals and reduce energy consumption, thereby promoting growth. It also has physiological effects such as anticonvulsant, hypotensive, sedative, and hypnotic.

[0066] Embodiment 1:

[0067] A lumbar protein peptide composition for improving microcirculatory disorders comprises the following components in parts by weight: 600-50 mg lumbar protein peptide, 150 mg red yeast rice extract, 30 mg natto powder, 300 mg small molecule collagen peptide, 150 mg spirulina platensis and 45 mg y-aminobutyric acid.

[0068] Embodiment 2:

[0069] A lumbar protein peptide composition for improving microcirculatory disorders comprises the following components in parts by weight: 1000 mg of lumbar protein peptide, 400 mg of red yeast rice extract, 80 mg of natto powder, 500 mg of small molecule collagen peptide, 200 mg of Spirulina platensis, and 80 mg of y-aminobutyric acid.

[0070] Embodiment 3:

[0071] A lumbar protein peptide composition for improving microcirculatory disorders comprises the following components in parts by weight: 1500 mg of lumbar protein peptide, 600 mg of red yeast rice extract, 150 mg of natto powder, 750 mg of small molecule collagen peptide, 300 mg of Spirulina platensis, and 120 mg of y-aminobutyric acid.

[0072] A preparation process of a lumbar protein peptide composition for improving microcirculatory disorders comprises the following steps:

[0073] 1. Raw material preparation

[0074] 1. Earthworm protein peptide:

[0075] Raw material selection: Choose fresh earthworms that are free of pests and diseases and impurities as raw materials.

[0076] Cleaning and drying: Wash the earthworms with clean water to remove mud, impurities and internal organs, and then dry them.

[0077] Enzymatic extraction: Add the cleaned and dried earthworms into an appropriate amount of enzymatic solution, and perform enzymatic treatment under suitable temperature and pH conditions to obtain earthworm protein peptide extract.

[0078] Separation and purification: The extract is separated and purified by ultrafiltration, nanofiltration, ion exchange and other methods to obtain high-purity earthworm protein peptide.

[0079] Concentration and drying: The purified earthworm protein peptide solution is concentrated and dried to obtain the desired earthworm protein peptide powder.

[0080] 2. Red Yeast Rice Extract:

[0081] Raw material selection: Choose high-quality indica rice, japonica rice or glutinous rice as raw materials.

[0082] Fermentation extraction: The raw materials are fermented with Monascus to obtain red yeast rice extract.

[0083] Purification and drying: The extract is purified to remove impurities and then dried to obtain red yeast rice extract powder.

[0084] 3. Natto powder:

[0085] Raw material selection: Choose high-quality soybeans as raw materials.

[0086] Soaking and steaming: Soak the soybeans for about 12 hours, then wash and steam them thoroughly.

[0087] Fermentation: Spray the natto bacteria into the mixture while it is still hot to ferment and obtain natto.

[0088] Drying and powdering: Put the fermented natto on a drying rack and dry it at about 40 degrees for 24 hours, then use a powdering machine to grind it into powder to obtain natto powder.

[0089] 4. Small molecule collagen peptides:

[0090] Raw material selection: Choose high-quality animal skins, bones, etc. as raw materials.

[0091] Enzymatic extraction: hydrolyzed into small molecule collagen peptides under the catalysis of biological enzymes.

[0092] Separation and purification: Control the distribution of molecular weight through membrane filtration and other methods to obtain small molecule collagen peptides with higher purity.

[0093] 5. Spirulina platensis:

[0094] Raw material selection: Choose high-quality Spirulina platensis as raw material.

[0095] Extraction: Soak the Spirulina dry powder in ethanol to defatted, then extract with water to obtain Spirulina extract.

[0096] Purification and drying: the extract is purified to remove impurities, and then dried to obtain Spirulina platensis powder.

[0097] 6. The preparation of γ-aminobutyric acid comprises the following steps:

[0098] Fermentation production: Through the microbial fermentation method, high-yield strains are selected for pre-culture, and then inoculated into the fermentation matrix containing suitable nutrients for fermentation.

[0099] Separation, extraction and purification: The fermentation broth is separated by centrifugation, filtrate and concentration, and then the γ-aminobutyric acid is purified by cooling crystallization, solvent crystallization and other methods.

[0100] 2. Proportion and Mixing

[0101] Proportioning by weight: Accurately weigh each component according to the ratio requirements and mix them evenly.

[0102] 3. Quality inspection and packaging

[0103] 1. Quality testing: The mixed composition is subjected to quality testing, including purity, content, biological activity and other indicators, to ensure that the product quality meets the relevant standards and requirements.

[0104] 2. Packaging: Use packaging materials with good sealing properties to prevent moisture, oxidation and contamination. During the packaging process, attention should be paid to maintaining environmental hygiene to avoid secondary contamination.

[0105] 4. Storage and Transportation

[0106] Store the packaged composition in a cool, dry place away from light and high temperature. During transportation, care should be taken to maintain the stability and safety of the product and avoid moisture, heat or other physical damage.

[0107] The term "comprise" or any other similar term is intended to cover a non-exclusive inclusion, such that a process, article, or apparatus / device that includes a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, article, or apparatus / device.

Claims

1. A lumbar protein peptide composition for improving microcirculatory disorders, characterized in that: The invention comprises the following components in parts by weight: 20-50 parts of earthworm protein peptide, 5-20 parts of red yeast rice extract, 1-5 parts of natto powder and 6-16 parts of small molecule collagen peptide; 5-10 parts of spirulina platensis and 1.5-4 parts of y-aminobutyric acid.

2. The earthworm protein peptide composition for improving microcirculatory disorders according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 25-45 parts of earthworm protein peptide, 8-10 parts of red yeast rice extract, 2-3 parts of natto powder and 8-12 parts of small molecule collagen peptide; 6-8 parts of spirulina platensis and 2-3 parts of y-aminobutyric acid.

3. The earthworm protein peptide composition for improving microcirculation disorders according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 20 parts of earthworm protein peptide, 5 parts of red yeast rice extract, 1 part of natto powder, 6 parts of small molecule collagen peptide, 5 parts of spirulina platensis and 1.5 parts of y-aminobutyric acid.

4. The earthworm protein peptide composition for improving microcirculatory disorders according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 50 parts of earthworm protein peptide, 20 parts of red yeast rice extract, 5 parts of natto powder, 16 parts of small molecule collagen peptide, 10 parts of spirulina platensis and 4 parts of y-aminobutyric acid.

5. A method for preparing a lumbar protein peptide composition for improving microcirculatory disorders, characterized in that: The following steps are involved: S1. Raw material preparation Prepare earthworm protein peptide powder, red yeast rice extract powder, natto powder, spirulina platensis powder, and γ-aminobutyric acid for later use; S2: Proportioning and mixing The raw materials prepared in S1 are mixed according to the following weight proportions: 20-50 parts of earthworm protein peptide, 20-50 parts of earthworm protein peptide, 5-20 parts of red yeast rice extract, 1-5 parts of natto powder and 6-16 parts of small molecule collagen peptide; 5-10 parts of Spirulina platensis and 1.5-4 parts of γ-aminobutyric acid. Each component is accurately weighed according to the ratio requirements and mixed evenly; S3: Quality Inspection and Packaging Quality testing: Conduct quality testing on the mixed composition, including purity, content, biological activity and other indicators to ensure that the product quality meets relevant standards and requirements; Packaging: Use packaging materials with good sealing properties to prevent moisture, oxidation and contamination. During the packaging process, attention should be paid to maintaining environmental hygiene to avoid secondary contamination; S4: Storage and Transportation Store the packaged composition in a cool, dry place away from light and high temperature. During transportation, care should be taken to maintain the stability and safety of the product and avoid moisture, heat or other physical damage.

6. The method for preparing a lumbar protein peptide composition for improving microcirculatory disorders according to claim 5, characterized in that: The preparation of the earthworm protein peptide in step S1 comprises the following steps: Raw material selection: Choose fresh earthworms that are free of pests and diseases and impurities as raw materials; Cleaning and drying: Wash the earthworms with clean water to remove mud, impurities and internal organs, and then dry them; Enzymatic extraction: Add the washed and dried earthworms into an appropriate amount of enzymatic solution, and perform enzymatic treatment under appropriate temperature and pH conditions to obtain earthworm protein peptide extract; Separation and purification: The extract is separated and purified by ultrafiltration, nanofiltration, ion exchange and other methods to obtain high-purity earthworm protein peptides; Concentration and drying: The purified earthworm protein peptide solution is concentrated and dried to obtain the desired earthworm protein peptide powder.

7. The method for preparing a earthworm protein peptide composition for improving microcirculatory disorders according to claim 5, characterized in that: The preparation of the red yeast rice extract in step S1 comprises the following steps: Raw material selection: Choose high-quality indica rice, japonica rice or glutinous rice as raw materials; Fermentation extraction: The raw materials are fermented with Monascus to obtain red yeast rice extract; Purification and drying: The extract is purified to remove impurities and then dried to obtain red yeast rice extract powder.

8. The method for preparing a earthworm protein peptide composition for improving microcirculatory disorders according to claim 5, characterized in that: The preparation of natto powder in step S1 comprises the following steps: Raw material selection: Choose high-quality soybeans as raw materials; Soaking and steaming: Soak the soybeans for about 12 hours, then wash and steam them thoroughly; Fermentation: spray the natto bacteria while it is still hot to ferment and obtain natto; Drying and powdering: Put the fermented natto on a drying rack and dry it at about 40 degrees for 24 hours, then use a powdering machine to grind it into powder to obtain natto powder.

9. The method for preparing a earthworm protein peptide composition for improving microcirculatory disorders according to claim 5, characterized in that: The preparation of the small molecule collagen peptide in step S1 comprises the following steps: Raw material selection: Choose high-quality animal skins, bones, etc. as raw materials; Enzymatic extraction: hydrolyzed into small molecule collagen peptides under the catalysis of biological enzymes; Separation and purification: Control the distribution of molecular weight through membrane filtration and other methods to obtain small molecule collagen peptides with higher purity.

10. The method for preparing a earthworm protein peptide composition for improving microcirculatory disorders according to claim 5, characterized in that: The preparation of Spirulina platensis in step S1 comprises the following steps: Raw material selection: Choose high-quality Spirulina platensis as raw material; Extraction: soak the spirulina powder in ethanol to defatted, then extract with water to obtain spirulina extract; Purification and drying: the extract is purified to remove impurities, and then dried to obtain Spirulina platensis powder.