Ultrasonic gel paste capable of being used for detecting inflammatory factors and lactic acid acidity and alkalinity in sweat
By adding ingredients such as Yago Nada Essence Oil to the ultrasonic gel paste, the problem of difficulty in detecting ultrasonic gel paste in the existing technology is solved, and the accurate detection of inflammation factors and lactic acid pH in sweat is achieved, and it is also able to soothe and clean the skin. The efficacy of
Patent Information
- Application Number
- CN202410718947.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-05
- Publication Date
- 2024-12-27
AI Technical Summary
The existing ultrasonic gel paste has complex ingredients and poor fluidity, which makes it difficult to detect inflammation factors and lactic acid pH in sweat, and has a large error value and cannot be accurately detected.
Add Yago Nada (Spike Spicy) essence oil, caffeine, lavender, sweet orange and red orange to the ultrasonic gel paste to form an ultrasonic gel paste with a specific ratio, which is used to collect and dilute skin secretions, and is combined with a kit Perform detection of inflammation factors and lactic acid pH.
Accurate detection of inflammation factors and lactic acid pH in sweat is achieved, providing the effect of soothing, cleaning and lifting the skin, while reducing detection errors.
Smart Images
Figure CN119185116A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of cosmetics, in particular to an ultrasonic gel cream which can be used for detecting inflammatory factors and lactic acid pH in sweat. Background Art
[0002] Yagnadar (spicatene) essential oil has the function of promoting blood circulation and has certain benefits for cardiovascular system. It is made according to the formula of Xinjiang Gufangsong Buli, and the most effective ratio is selected after research by Hong Kong University of Science and Technology. This formula is added to the ultrasound gel with an appropriate solvent to make it have the effect of promoting blood circulation. The main secretions of human skin are sweat and fat, which are secreted by sweat glands and sebaceous glands respectively. Under normal circumstances, the sweat secreted by small sweat glands is colorless, transparent, and acidic (pH4.5-5.5). When sweating a lot, the alkalinity of sweat increases (about pH7.0). Water accounts for 99% of sweat, and other components only account for 1%, the latter including inorganic ions, lactic acid, urea, etc. Sebum is the whole sebaceous gland cell rupture, and all the intracellular contents are discharged into the lumen, distributed on the skin surface to form a membrane. Sebum is a mixture of various lipids, mainly containing squalene, wax fat, triglyceride and cholesterol ester.
[0003] At present, the detection technology for human inflammatory factors, lactic acid and other substances on the market has developed maturely. The relevant test kits are easy and quick to purchase, and can detect specific values in a short time, with an accuracy of pg / mL. The same is true for pH detection technology, from pH reagents to precise acid and alkaline detectors, which can detect acid and alkaline values. However, due to the complex ingredients and poor fluidity of ultrasonic gel, it is easy to cause detection difficulties, large errors and other adverse results. Summary of the invention
[0004] 1. Technical issues to be resolved
[0005] In view of the deficiencies of the prior art, the present invention provides an ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat. By adding agave spicate (spicate) essential oil to the ultrasonic gel cream, after normal use, the used gel cream is collected and diluted, and the inflammatory factors, lactic acid, and pH are detected using a kit.
[0006] (II) Technical solution
[0007] To achieve the above purpose, the present invention is implemented through the following technical scheme: an ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat, and its raw materials include by weight percentage: 0.6-1% spikenard essential oil, 0.6% caffeine, 0.6% lavender, 0.2% sweet orange, 0.2% red tangerine and 97.4%-97.8% base material.
[0008] Preferably, the raw materials include, by weight percentage: 0.8% spikenard essential oil, 0.6% caffeine, 0.6% lavender, 0.2% sweet orange, 0.2% red tangerine and 97.6% base material.
[0009] Preferably, the raw materials include, by weight percentage: 0.6% spikenard essential oil, 0.6% caffeine, 0.6% lavender, 0.2% sweet orange, 0.2% red tangerine and 97.8% base material.
[0010] Preferably, the raw materials include, by weight percentage: 1% spikenard essential oil, 0.6% caffeine, 0.6% lavender, 0.2% sweet orange, 0.2% red tangerine and 97.4% base material.
[0011] The present invention also provides an application of an ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat in the skin on the surface of the human body, which has the effects of soothing, cleaning and lifting the skin.
[0012] Preferably, the ultrasonic gel has the function of collecting secretions on the skin surface after normal use.
[0013] Preferably, the collected skin surface secretions are first diluted with a collection dilution solution, and after dilution, the specific content value can be detected by a conventional inflammatory factor lactic acid kit, and the specific pH can be measured by a pH indicator.
[0014] Preferably, the collection dilution solution is sterilized deionized water, and the ratio of gel cream to water is 1:1.
[0015] Preferably, the inflammatory factors are specifically TNF-α and IL-6.
[0016] (III) Beneficial effects
[0017] The present invention provides an ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat. Compared with the prior art, the ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat has the following beneficial effects: the ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat is added with 0.6% of spicatene essential oil, and the formula ingredients also include flavoring ingredients of 0.6% caffeine, 0.6% lavender, 0.2% sweet orange, and 0.2% red tangerine. After adding spicatene essential oil to the ultrasonic gel cream, after normal use, the used gel cream is collected and diluted, and the inflammatory factors, lactic acid, and pH are detected by a kit. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 This is the first product picture of the gel cream of the present invention;
[0019] Figure 2 This is a second product picture of the gel cream of the present invention;
[0020] Figure 3 This is a schematic diagram of the standard curve for TNF-α detection by the inventors;
[0021] Figure 4 This is a test chart of TNF-α of the gel cream of the present invention;
[0022] Figure 5 This is a schematic diagram of the IL-6 detection standard curve of the inventor;
[0023] Figure 6 This is the IL-6 test chart of the gel cream of the present invention;
[0024] Figure 7 This is a schematic diagram of the standard curve for detecting human lactate of the present invention;
[0025] Figure 8 This is a lactic acid test chart of the gel cream of the present invention. DETAILED DESCRIPTION
[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0027] See also Figure 1-8 The embodiments of the present invention provide four technical solutions: an ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat, specifically including the following embodiments:
[0028] Implementation case 1: Manufacturing of Yage Nada (spicate) essence ultrasonic gel cream;
[0029] On the base of basic ultrasonic gel cream, 0.6% of agave nectarine essential oil, 0.6% of caffeine, 0.6% of lavender, 0.2% of sweet orange and 0.2% of red tangerine are added to prepare agave nectarine essential oil ultrasonic gel cream.
[0030] Implementation case 2: Detection of inflammatory factor TNF-α in ultrasonic gel ointment;
[0031] Implementation method:
[0032] Artificial sweat was prepared according to ISO 3160-2 standard, and its composition was 20 g sodium chloride, 17.5 g ammonium chloride, 5.0 g urea, 5.0 g acetic acid and 15.0 g lactic acid. The pH of artificial sweat was adjusted to 4.8 with 0.1 mM NaOH.
[0033] Artificial sweat with a fixed human TNF-α concentration (PH = 4.8) was used to establish a concentration gradient (pg / mL) of 7.8125, 15.625, 31.25, 62.5, 125, 250, and 500 for the experiment. After mixing sweat: ultrasonic gel at a ratio of 1:1, TNF-α was detected using the human TNF-α ELISA KIT purchased from Elabscience.
[0034] Implementation results:
[0035] A standard curve for human TNF-α detection was established to detect the content of TNF-α in the ultrasonic gel cream, with a detection limit of 62.5 pg / mL. This can preliminarily determine the concentration range of human TNF-α in the gel cream, and thus infer the inflammation at the site of action of the ultrasonic gel cream.
[0036] Implementation case 3: Ultrasonic gel ointment inflammatory factor IL-6 detection;
[0037] Artificial sweat was prepared according to ISO 3160-2 standard, and its composition was 20 g sodium chloride, 17.5 g ammonium chloride, 5.0 g urea, 5.0 g acetic acid and 15.0 g lactic acid. The pH of artificial sweat was adjusted to 4.8 with 0.1 mM NaOH.
[0038] Artificial sweat with a fixed human IL-6 concentration (PH = 4.8) was used to establish a concentration gradient (pg / mL) of 7.8125, 15.625, 31.25, 62.5, 125, 250, 500 for the experiment. After mixing with sweat: ultrasonic gel = 1:1, IL-6 was detected using the human IL-6 ELISA KIT purchased from Sangon Biotech.
[0039] Implementation Results
[0040] A human IL-6 detection standard curve was established to detect the content of IL-6 in the ultrasound gel cream, with a detection limit of 25 pg / mL. This can preliminarily determine the concentration range of human IL-6 in the gel cream, thereby inferring the inflammation at the site of action of the ultrasound gel cream.
[0041] Implementation case 4: Ultrasonic gel lactic acid testing;
[0042] Artificial sweat was prepared according to ISO 3160-2 standard, and its components were 20g sodium chloride, 17.5g ammonium chloride, 5.0g urea, and 5.0g acetic acid. The pH of artificial sweat was adjusted to 4.8 with 0.1mM NaOH, and different concentrations of lactic acid standard were added, and the concentrations (pmoL / mL) were 0.078; 0.15625; 0.3125; 0.625; 1; 2 respectively.
[0043] Artificial sweat with a fixed human lactic acid concentration (PH = 4.8) was used to establish a concentration gradient (pmoL / mL) of 0.039; 0.078; 0.15625; 0.625; 1 for the experiment. After mixing sweat: ultrasonic gel cream = 1:1, lactic acid detection was performed using a human lactate detection kit purchased from Sangon Biotech.
[0044] Implementation Results
[0045] A human lactic acid detection standard curve was established to detect the content of ultrasonic gel containing lactic acid. The detection limit was 0.039pmoL / mL, which could preliminarily determine the concentration range of human lactic acid in the gel, and thus infer the fatigue condition of the site of action of the ultrasonic gel.
[0046] In summary, the present invention adds 0.6% of spikenard essential oil, and the formula ingredients also include flavoring ingredients such as 0.6% caffeine, 0.6% lavender, 0.2% sweet orange, and 0.2% red tangerine. The spikenard essential oil is added to the ultrasonic gel cream, and after normal use, the used gel cream is collected and diluted, and the inflammatory factors, lactic acid, and pH are detected by a kit.
[0047] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.
[0048] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.
[0049] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. An ultrasonic gel cream that can be used to detect inflammatory factors and lactic acid pH in sweat, characterized in that: The raw materials include, by weight percentage, 0.6-1% of spikenard essential oil, 0.6% of caffeine, 0.6% of lavender, 0.2% of sweet orange, 0.2% of red tangerine and 97.4%-97.8% of base material.
2. The ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 1, characterized in that: The raw materials include, by weight percentage, 0.8% of spikenard essential oil, 0.6% of caffeine, 0.6% of lavender, 0.2% of sweet orange, 0.2% of red tangerine and 97.6% of base material.
3. The ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 1, characterized in that: The raw materials include, by weight percentage, 0.6% of spikenard essential oil, 0.6% of caffeine, 0.6% of lavender, 0.2% of sweet orange, 0.2% of red tangerine and 97.8% of base material.
4. The ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 1, characterized in that: The raw materials include, by weight percentage, 1% of spikenard essential oil, 0.6% of caffeine, 0.6% of lavender, 0.2% of sweet orange, 0.2% of red tangerine and 97.4% of base material.
5. The use of the ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to any one of claims 1 to 4 in the skin on the surface of the human body has the effects of soothing, cleaning and lifting the skin.
6. The use of the ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 5 in human surface skin, characterized in that: The ultrasonic gel cream has the function of collecting secretions on the skin surface after normal use.
7. The use of the ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 6 in human surface skin, characterized in that: The collected skin surface secretions are first diluted with a collection dilution solution, and after dilution, the specific content value can be detected by a conventional inflammatory factor lactic acid test kit, and the specific pH can be measured by a pH indicator.
8. The use of the ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 7 in human surface skin, characterized in that: The collection dilution solution is sterilized deionized water, and the ratio of gel cream to water is 1:
1.
9. The use of the ultrasonic gel cream for detecting inflammatory factors and lactic acid pH in sweat according to claim 7 in human surface skin, characterized in that: The inflammatory factors are specifically TNF-α and IL-6.