Traditional Chinese medicine composition for treating lung cancer and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines and discloses a traditional Chinese medicine composition for treating lung cancer and a preparation method. The traditional Chinese medicine composition for treating the lung cancer is prepared from the following components: 8 to 15g of herba ephedrae, 30 to 60g of almond, 60 to 160g of semen coicis, 15 to 20g of radix ophiopogonis, 10 to 30g of ginseng, 60 to 150g of rhizoma dioscoreae, 9 to 15g of radix bupleuri and 15 to 30g of fructus aurantii immaturus. From the physiological function of the lung and the pathological change of the lung cancer, the invention provides a new thought for improving the ventilation and air exchange functions of the lung and preventing and treating the lung cancer by the traditional Chinese medicine, combines the traditional'methods' and the modern pharmacology'science ', and achieves an obvious curative effect in early clinical application.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating lung cancer and a preparation method thereof. Background Art

[0002] Lung cancer is the malignant tumor with the highest mortality rate among cancers. Its morbidity and mortality rate are both the highest among cancers in the world, which seriously endangers human health. Since the symptoms of early lung cancer are not obvious, most lung cancer patients miss the best surgical period when they are first diagnosed. Currently, chemotherapy, targeted therapy, immunotherapy, etc. are mainly used in clinic. However, chemotherapy kills tumor cells while also destroying normal cells, which has great adverse reactions and affects the quality of life of patients. The 5-year survival rate is less than 20%. Therefore, new technologies and drugs for the treatment of lung cancer are expected in clinic.

[0003] Lung cancer belongs to the category of "lung accumulation", "breathing congestion", "chest pain", "cough", "hemoptysis", "fatigue cough", "lung gangrene" in traditional Chinese medicine. "Suwen·Qibinglun" says: "The disease is fullness under the ribs and upward reversal of qi, the disease is called breath accumulation." "Suwen·Kelun" states: "The symptoms of lung cough are coughing and wheezing with sound, and even spitting blood." At present, the treatment of tumors with traditional Chinese medicine is not only reported in literature but also used in clinical applications. Most of them use anti-cancer Chinese medicines such as Hedyotis diffusa and Lobelia, but there are no substantial breakthroughs in the results. In some sense, it is only symptomatic treatment. In fact, from the perspective of the theory of traditional Chinese medicine system, changing the internal environment of the human body that forms cancer is the treatment from the "root". Recently, the Journal of Traditional Chinese Medicine published an article by Shanghai University of Traditional Chinese Medicine entitled "The Preliminary Construction of the Theory of Tumor Metastasis in the Perspective of Integrated Traditional Chinese and Western Medicine", which shows that cancer metastasis is the result of the dynamic evolution of cancer cells in the body and their surrounding environmental factors over time and space. Traditional Chinese medicine plays an important role in regulating the proliferation, apoptosis, adhesion and migration of cancer cells, inhibiting tumor angiogenesis, changing the host immune system, inhibiting tumor growth, and assisting in reducing the adverse reactions of chemotherapy. Studies have found that lung function deficiency occurs in the early stage of lung cancer and its lung cancer cells have hypoxia characteristics. In addition, the ancients used the bellows to describe the lungs, which is to regard the lungs as the bellows of the human body. This metaphor refers to the function of the lungs to control qi, control breathing, and regulate qi.

[0004] We got inspiration from the above research and metaphors, and based on this, the treatment formula breaks the traditional concept of simple anti-cancer. Based on the physiological function of the lungs and the pathological changes of lung cancer, we put forward a new idea of ​​using traditional Chinese medicine to improve the "ventilation and air exchange" function of the lungs to prevent and treat lung cancer. With the "lungs" as the center, multiple organ systems coordinate to change the way of thinking of the internal environment of "cancer tumors", so that the bad "children" of cancer cells can be transformed into good "children" of normal cells through "ventilation and air exchange of the lungs". This Chinese medicine composition for the treatment of lung cancer is based on the above theory and follows the formula of monarch, minister, adjuvant and envoy. It can be said that it has traditional "rules" and combines modern pharmacological "scientific" formulas. It has been clinically applied in the early stage and has achieved significant therapeutic effects. It is intended to invent a Chinese medicine composition for the treatment of lung cancer. Summary of the invention

[0005] In view of the problems existing in the prior art, the present invention provides a Chinese medicine composition for treating lung cancer and a preparation method thereof.

[0006] , invent a Chinese medicine composition for treating lung cancer. The dosage range of this prescription also includes: 8-15g of ephedra, 30-60g of apricot kernel, 60-160g of coix seed, 15-20g of ophiopogon, 10-30g of ginseng, 60-150g of yam, 9-15g of bupleurum, 15-30g of immature bitter orange, and so on.

[0007] The present invention provides a traditional Chinese medicine composition for treating lung cancer, comprising: 8g of ephedra, 30g of apricot kernel, 60g of coix seed, 15g of ophiopogon japonicus, 10g of ginseng, 60g of yam, 9g of bupleurum, 15g of immature bitter orange, etc.

[0008] , A method for preparing the Chinese medicine composition for treating lung cancer described in 1 and 2, comprising the following steps: Step 1: remove impurities, wash, dry and sterilize ephedra, almond, coix seed, ophiopogon japonicus, ginseng, yam, bupleurum and immature bitter orange, and set aside; Step 2: using a grinder to coarsely grind the above Chinese medicine raw materials in sequence to obtain raw material coarse powder; Step 3: Superfinely pulverize the coarse powder of Chinese medicine in sequence by using a superfine pulverizer to obtain raw material fine powder; Step 4: Evenly mix the obtained raw material powder according to the formula components, further sterilize by spraying with 75% alcohol for 3 to 5 minutes, and then package with an automatic sealing machine.

[0009] In addition, the preparation method of the Chinese medicine composition for treating lung cancer further comprises the following steps: Steps of decoction: Take Chinese herbal medicine slices such as ephedra, almond, coix seed, ophiopogon, ginseng, yam, bupleurum, immature bitter orange and the like, and decoct them into decoction according to the traditional preparation method. Soak each of the above Chinese herbal medicine slices in 600-1200 ml of pure cold water for 30 minutes, boil in a casserole for 25-40 minutes, then pour out the decoction, add 300 ml of pure cold water and boil, pour out the decoction for 15 minutes, mix and take warm in two doses.

[0010] Steps for taking Chinese medicine granules: Choose the above-mentioned Chinese medicine granules produced by Shenwei Pharmaceutical Group, Guangdong Yifang Pharmaceutical Co., Ltd., Shijiazhuang Yiling Pharmaceutical Co., Ltd., Beijing Kangrentang Pharmaceutical Co., Ltd., and other Chinese medicine granules produced in China, and the drug formulas, dosage ratios and ranges. Add 100-300 ml of boiled water to each dose of the above Chinese medicine granules according to the dosage, stir, soak for 10 minutes, and take warm.

[0011] Compared with the prior art, this technology invents a Chinese medicine composition for treating lung cancer, which has the following characteristics and effects: Theory and inspiration: Based on the etiology and pathogenesis of lung cancer, the anatomy, physiology, and pathology of the lungs, the ancient use of bellows to describe the lungs, and the inspiration gained from surgical "ventilation and drainage", the idea of ​​"ventilation and air exchange" was proposed to form a Chinese medicine composition for the treatment of lung cancer with the effect of "clearing the lungs and resolving knots".

[0012] Effects and principles: The treatment principles of the composition include: clearing the lungs and ventilating, clearing the lungs and removing phlegm and dampness, clearing the lungs and replenishing qi, clearing the lungs and replenishing the kidneys, clearing the lungs and replenishing the spleen, raising the liver and lowering the lungs, and clearing the heart and moistening the lungs. In theory, a Chinese medicine composition for treating lung cancer with "lungs" as the center and ephedra as the monarch drug, "tongfei huajie prescription" for clearing the lungs and breaking up knots, is established. Following the orderly classical prescription thinking of "monarch, minister, assistant, and messenger", a new prescription is formed in combination with modern pharmacological research, which embodies "respecting the ancients without sticking to the ancients, and innovating without forgetting the ancients", and is a theoretical and practical innovation in the treatment of lung cancer with "principle, method, prescription, and medicine".

[0013] Innovation and efficacy: Breaking the traditional concept of simple anti-cancer. Proposing a new idea of ​​using traditional Chinese medicine to improve the "ventilation and air exchange" function of the lungs to treat lung cancer. The application of lung cancer Chinese medicine combination to treat lung cancer patients is in line with current relevant literature, such as: Zhang Houyun et al. reported that the clinical effect of using Sijunzi Decoction combined with Shashen Maidong Decoction plus or minus combined targeted treatment of EGFR mutation in advanced lung cancer was 66.7%, which was statistically significant compared with the total effective rate of our research group of 90.4%. (P<0.05). It also reflects the characteristics of the prescription of the classic Chinese medicine "Treatise on Febrile Diseases", with simple and effective medicines, rich sources of medicines, simple preparation, and significant efficacy.

[0014] Formulating ideas: refer to the basic and classical theories of traditional Chinese medicine, "opening and dispersing lung qi", "lung and large intestine are exterior and interior to each other", "liver rises on the left, lung hides on the right" (Huangdi Neijing "Suwen·Acupuncture Prohibition Theory"), "cultivating earth and raising metal". Its principles are: opening and dispersing lung qi, treating lung and intestine at the same time, raising liver and descending lung, nourishing spleen and strengthening lung, clearing heart and moistening lung, etc.

[0015] Functions of each component: Ephedra: pungent, enters the lung and bladder meridians. It is the monarch drug and has the function of clearing and promoting lung qi.

[0016] Apricot kernel: It is a ministerial drug, belonging to the lung and large intestine meridians. Bitter apricot kernel can clear and open the meridians, break up obstructions and lower the adverse effects. It is good at relieving numbness and stopping wheezing, reducing swelling and moistening dryness, regulating the depression of qi, promoting lung function without adding heat, clearing the lungs without retaining pathogens, and making the lung qi descend with power, soothing wheezing and urinating. It is used for mutual control.

[0017] Ophiopogon japonicus: Ophiopogon japonicus is sweet, slightly bitter, and slightly cold in nature. It enters the stomach, lung, and heart meridians. It has the effects of nourishing yin and moistening the lungs, benefiting the stomach and producing fluid, clearing the heart and relieving restlessness. It is used for dry cough due to lung dryness, tuberculosis due to yin deficiency, sore throat, thirst due to loss of fluid, internal heat and thirst, restlessness and insomnia, dry intestines and constipation, etc. "Compendium of Materia Medica" says that Ophiopogon japonicus is "sweet, slightly bitter, and slightly cold. It moistens the lungs and clears the heart, relieves heat and produces fluid, resolves phlegm and stops vomiting, and treats cough and diuresis." "Medical Records of Zhongzhong Canxi" says that it "can enter the stomach to nourish gastric fluid, stimulate appetite, and can enter the spleen to help the spleen disperse essence to the lungs, calm asthma and cough." Coix seeds: sweet and light in taste, slightly cold in nature. Enter the spleen, stomach, and lung meridians. It has the functions of strengthening the spleen and eliminating dampness, clearing heat and draining pus, removing numbness, and promoting diuresis.

[0018] Ginseng: warm in nature, sweet, slightly bitter, slightly warm in taste. Enters the spleen and lung meridians. Greatly replenishes vital energy, restores the pulse and consolidates the body, replenishes the spleen and lungs, promotes the production of body fluids, and calms the mind. Used for weakness and fainting, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency, wheezing and coughing, and thirst due to loss of body fluids.

[0019] Chinese Yam: Sweet, neutral. Enters the spleen, lung, and kidney meridians. It has the effects of replenishing qi and nourishing yin, tonifying the spleen, lung, and kidney, and stopping leucorrhea. It is used to treat spleen deficiency, poor appetite, loose stools, excessive leucorrhea, lung deficiency, wheezing and coughing, kidney deficiency, spermatorrhea, leucorrhea, frequent urination, and deficiency heat and thirst.

[0020] Bupleurum: slightly cold in nature, bitter and pungent in taste, enters the liver meridian and gallbladder meridian, has the effects of soothing the liver and gallbladder, soothing qi and relieving depression, and dispersing fire. It can relieve heat, soothe the liver and relieve depression, and raise yang qi. Indications: liver depression and qi stagnation, chest and rib pain, rectal prolapse, uterine shedding, and irregular menstruation.

[0021] Citrus aurantium: bitter, pungent, sour, slightly cold, enters the spleen, stomach meridian, and large intestine. Efficacy: breaks up qi and eliminates stagnation, resolves phlegm and relieves lumps. Used for stagnation of internal stagnation, fullness and pain, heaviness after diarrhea, constipation, phlegm stagnation and qi obstruction, chest pain, chest congestion, and sagging of internal organs.

[0022] Pharmacological studies of each component: Ephedra and almond: They are the "pair of medicines" in traditional Chinese medicine formulas. Ephedra promotes lung qi, while almond reduces lung qi, and they are most suitable for improving the physiological function of the lungs. Related studies have found that the antiasthmatic effect of ephedrine, the main component of ephedra, is related to central effects, which can promote the relaxation of bronchial smooth muscles and contraction of mucosal capillaries; in addition, ephedrine can also act on the peripheral system to stimulate β2 receptors in lung tissue, thereby relaxing bronchial smooth muscles. Hydrocyanic acid, the product of amygdalin after metabolic hydrolysis, can inhibit the respiratory center, thereby achieving the effect of relieving cough and relieving asthma; it can also inhibit the inflammatory response of lung tissue through the peripheral system, reduce mucin secretion and inflammatory cell infiltration in the lung interstitium to achieve the effect of relieving cough and relieving asthma.

[0023] Ophiopogon japonicus: Modern pharmacological research also shows that Ophiopogon japonicus mainly contains scutellaria baicalensis, steroidal saponins, alkaloids, sitosterol, glucose, amino acids, vitamins, etc., which have the effects of anti-fatigue, scavenging free radicals, improving cellular immune function and lowering blood sugar. In addition, Ophiopogon japonicus has sedative, hypnotic, anti-myocardial ischemia, anti-arrhythmia, anti-tumor and other effects.

[0024] Coix seed: It can strengthen the spleen and eliminate dampness, that is, it can remove the "dampness" in the lungs. Modern pharmacology has confirmed that the Chinese medicine coix seed has a significant anti-cancer effect. Its product Kanglaite developed from the Chinese medicine coix seed has a biphasic broad-spectrum anti-cancer effect. The main ingredient is coix seed oil, which can curb the spread of cancer cells and control cell signaling pathways. It can cause cancer cells to die naturally; it can stimulate immunity, balance immune function, and effectively inhibit the formation of blood vessels that affect cancer. From the perspective of traditional Chinese medicine, we believe that coix seed can promote the "dehydration" of lung cancer cells and cause lung cancer cells to die naturally.

[0025] Ginseng: The lack of ventilation and air exchange in lung cancer indicates that the lung itself has lung qi deficiency. Our research group published at the 13th International Conference on Medical and Education Informatization in 2023: Exploring the prevention and treatment of lung cancer based on the idea of ​​"ventilation and air exchange", which attracted the attention and citation of scholars at home and abroad. "Huangdi Neijing·Suwen·Acupuncture Theory" states that "the positive energy is stored inside and the evil cannot interfere". Therefore, ephedra and ginseng are matched. Ephedra promotes the flow of lung qi. Under the "guiding meridian" effect of ephedra, ginseng replenishes lung qi. In fact, it is the idea of ​​using ephedra to expel evil and ginseng to strengthen the body. In recent years, ginseng has attracted widespread attention in the field of anti-lung cancer research. Traditional Chinese medicine has accumulated a lot of theoretical basis and practical experience in the treatment of lung cancer. Ginseng has the effects of greatly replenishing vital energy, restoring pulse and consolidating deficiency, replenishing spleen and lung, and promoting body fluid and nourishing blood. Ginseng saponins are the main active ingredients of ginseng, which have anti-cancer and anti-inflammatory activities. At present, researchers at home and abroad have conducted a lot of research on the mechanism and pharmacological activity of ginsenosides in intervening lung cancer. The results showed that ginsenosides can effectively inhibit lung cancer cell proliferation, invasion, migration, epithelial-mesenchymal transition and angiogenesis, inhibit drug resistance, enhance chemotherapy sensitivity and efficacy, promote lung cancer cell apoptosis and autophagy, regulate tumor microenvironment, and regulate immunity, thereby delaying the occurrence and development of lung cancer.

[0026] Chinese Yam: nourishes the spleen, lungs, and kidneys. The main idea here is to nourish the spleen, because Chinese medicine has the saying "cultivating the soil to produce gold", and the function of the lungs can be increased by nourishing the spleen; "Chinese Herbal Medicine" magazine in the fourth issue of 2020 "Study on the Chemical Components and Anticancer Activity Screening of Chinese Yam Stems and Leaves", the experiment further systematically separated the stems and leaves of Chinese yam, identified 20 compounds and conducted preliminary screening for the inhibitory effects on the proliferation of MCF-7 cells and HepG2 cells. The results showed that some compounds have certain anti-cancer activity.

[0027] Bupleurum: It not only has the functions of soothing the liver and promoting bile secretion, soothing qi and relieving depression, and clearing the triple energizer, because the triple energizer is the pathway for water metabolism, but also follows the "Suwen·Lajinlun" chapter: "The liver is born on the left, and the lung is hidden on the right", that is, the liver belongs to wood and is responsible for ascending and developing, so it is located on the left, in the east; the lung belongs to metal and is responsible for contraction and descending, so it is located on the right, in the west; the formula uses bupleurum to ascend and apricot kernel to descend the lung, which is conducive to the smooth flow of qi and the discharge of toxins in the body. The third issue of "Chinese Journal of Traditional Chinese Medicine" in 2022 reported "Exploring the significance of high expression of CCNB1 in lung adenocarcinoma and the intervention mechanism of bupleurosaponin D based on TCGA data mining and molecular docking technology", and explored the intervention mechanism of bupleurosaponin d on lung adenocarcinoma through TCGA data mining and molecular docking technology, and found that CCNB1 gene is one of the important clinical prognostic factors of lung adenocarcinoma, and bupleurosaponin d has a binding site with CCNB1 to play an anti-lung adenocarcinoma role. "Bupleurum saponin A improves the drug resistance of A549 / DDP cells through the Wnt / β-catenin pathway" was reported in the 11th issue of "Chinese Journal of Experimental Traditional Chinese Medicine" in 2021. The article shows that Bupleurum saponin A has also been widely used in anti-tumor treatment in recent years. Cisplatin is a first-line chemotherapy drug for the treatment of non-small cell lung cancer, but with the increase of drug resistance in the later stage, it is easy to cause tumor growth or distant metastasis. Bupleurum saponin A may increase the sensitivity of lung cancer cells to cisplatin by regulating the Wnt / β-catenin signaling pathway, thereby reducing drug resistance. It can be seen that the preventive and therapeutic effects of Bupleurum total saponins on lung cancer have a multi-pathway and multi-target trend.

[0028] Citrus aurantium: enters the spleen, stomach meridian, and large intestine. According to the theory that "the lung and large intestine are exterior and interior to each other", the function of the lung is improved by improving the function of the large intestine. The main components of Citrus aurantium contain flavonoids, alkaloids, volatile oils, etc., which have the effects of anti-oxidation, smooth muscle excitation, blood pressure increase, antibacterial, analgesia, central nervous system inhibition, blood sugar reduction, and liver protection. DETAILED DESCRIPTION Example

[0029] Take 8g of Ephedra, 30g of Apricot, 60g of Coix Seed, 15g of Ophiopogon, 10g of Ginseng, 60g of Chinese Yam, 9g of Bupleurum, 15g of Citrus aurantium, soak each of the above Chinese medicine slices in 600-1200ml of pure cold water for 30 minutes, boil in a casserole for 25-40 minutes, then pour out the soup, add 300ml of pure cold water and boil, pour out the soup after 15 minutes, mix and take warm twice. Take one dose in the morning and evening, and take it for seven consecutive days as a course of treatment.

[0030] Typical cases: The patient, a 81-year-old female of Han nationality, was treated on August 31, 2022, with the main complaint of "chest and shortness of breath for 2 months" and constipation. The patient had chest tightness and shortness of breath without obvious cause 2 months ago, without fever, cough, and cough. She was treated at the local county hospital and improved after infusion treatment (unknown details). Chest CT showed a left lung lesion. On August 22, 2022, for further diagnosis and treatment, she was treated at the People's Hospital Affiliated to Peking University and was admitted to the hospital for "lung lesion (left)" in the outpatient department. Hospitalization number: 4441486; Past history: 6 years ago, she had a right arm fracture due to a car accident and underwent open reduction and plate internal fixation. She has a 10-year history of hypertension, with a maximum systolic blood pressure of 180mmHg, controlled by reserpine and aspirin (unknown details). Arrhythmia and premature beats appeared more than 10 years ago, and relevant examinations were completed after admission. Considering that the left upper lobe of the lung was clear, according to the results of electrocardiogram, Ho1ter, and coronary CI, the cardiology department was invited to consult to consider the patient's atrial fibrillation, coronary heart disease, stable angina pectoris, and hypertension. According to the results of pulmonary function, the respiratory department was invited to consult to consider emphysema and structural lung disease, and the pulmonary ventilation reserve function was poor. PET / CT showed soft tissue shadows with increased FDG metabolism in the left upper lobe of the lung, and peripheral lung cancer was considered: multiple lymph nodes with increased FDG metabolism in the right supraclavicular, mediastinal, and bilateral hilar pulmonary nodes, and the possibility of tumor metastasis was considered high. Comprehensive pre- and post-admission tests, examinations, and necessary consultation opinions considered that the patient was old and had multiple underlying diseases, and the surgical risk was high. And PET / CT showed lymph node metastasis. On 2022-08-30, a CT-localized lesion puncture biopsy was performed under local anesthesia, and the specimen was sent for paraffin pathology. Pathology number: BI0004787, hospitalization number: 4441486, pathological diagnosis: (left lung) puncture biopsy specimen: pulmonary invasive adenocarcinoma, immunohistochemistry results: TTF-1 (+), p40 (-), CK5 / 6 (-), ALK-Ventana (this case: -; positive control: +: negative control: -). Considering the patient's age and lymph node metastasis, it is no longer an indication for surgery. It is recommended to return to the local conservative treatment. After being discharged from the hospital on the morning of August 31, 2022, come to our hospital for treatment in time.

[0031] According to the main complaint, the patient had chest pain and shortness of breath for 2 months, accompanied by constipation. Combined with the pathological examination of Peking University People's Hospital, the diagnosis of lung cancer was clear, the upper part of the tongue was red, and the middle part of the tongue was yellow and greasy. The Chinese medicine diagnosis was lung and spleen damp-heat, and the treatment was to clear the lungs, strengthen the spleen and eliminate dampness. The Chinese medicine composition for treating lung cancer was given: 8g of ephedra, 30g of almonds, 60g of coix seeds, 15g of ophiopogon, 10g of ginseng, 60g of yam, 9g of bupleurum, and 15g of immature bitter orange. After one week of treatment, the above symptoms improved significantly. After three months of continuous use, the symptoms disappeared. The CT reexamination was significantly smaller than before treatment. The follow-up visit was on October 16, 2024. Currently, he lives like a normal person without any discomfort. Example

[0032] Clinical data: The selection period was from March 2021 to April 2024. 43 patients with lung cancer were treated in the Second Affiliated Hospital of Xingtai Medical College and were divided into a control group and an observation group. There were 21 cases in the observation group, including 13 males and 8 females, aged 43 to 86 years old; there were 22 cases in the control group, including 15 males and 7 females, aged 46 to 84 years old; there was no significant difference in age between the two groups (P>0.05). Diagnostic criteria, exclusion criteria, inclusion criteria: The diagnostic criteria were based on the 2015 edition of the Chinese Primary Lung Cancer Diagnosis Guidelines.

[0033] The standard of TCM syndrome differentiation is based on the Guiding Principles for Clinical Research of New TCM Drugs (Trial Implementation). Exclusion criteria: patients with symptomatic brain metastases that are not under control; patients with mental illness or cognitive impairment; patients with active tuberculosis and other serious infectious diseases; patients with poor compliance and unable to be visited regularly.

[0034] Inclusion criteria: clear pathological diagnosis; clinical stage III-IV based on clinical symptoms and imaging results; patients cannot tolerate surgical treatment; patients are conscious and can cooperate with the research plan for treatment and follow-up.

[0035] Treatment Efficacy evaluation criteria: According to the patient's lesions, the treatment is divided into complete remission (tumor disappears and lasts for >28 days), partial remission (tumor shrinks by 50% and lasts for >28 days), stable (tumor shrinks by less than 50% or increases by less than 25%), and worsening (tumor increases by 25%). The total effective rate = (number of complete remission cases + number of partial remission cases) / total number of cases × 100%.

[0036] Control group: patients were given gemcitabine hydrochloride injection on the 1st to 8th day of treatment, 1.0g / ml gemcitabine hydrochloride was dissolved in 250ml, 0.9% saline for intravenous drip treatment; cisplatin injection was given on the 1st to 3rd day of chemotherapy, 25mg / ml cisplatin was dissolved in 250ml, 0.9% saline for intravenous drip treatment. Observation group: On the basis of conventional western medicine chemotherapy, the "Tongfei Huajie Chinese medicine prescription" was used for treatment. The prescription composition is: Ephedra 8-12g, Apricot 20-30g, Coix seed 80-120g, Ophiopogon japonicus 10-20g, Ginseng 10-30g, Chinese yam 40-120g, Bupleurum 9-15g, Citrus aurantium 15g. Decoction, 1 dose per day, 2 times a day. Or use the same dose and the same method of taking Chinese medicine granules. Both groups of patients were treated for 12 weeks and the efficacy was evaluated.

[0037] Results: Comparison of clinical efficacy and disease control rate between the two groups of patients with lung cancer [(%)]: In the control group, 22 cases were included, among which 7 cases had complete remission (36.3), 6 cases had partial remission (27.2), 4 cases were stable (18.1), 5 cases were worse (22.7), and 13 cases were effective in total (59.0); in the observation group, 21 cases were included, among which 9 cases had complete remission (42.8), 10 cases had partial remission (47.6), 2 cases were stable (9.8), 0 cases were worse (), and 19 cases were effective in total (90.4); the total effective rate of the observation group was significantly higher than that of the control group (P<0.05).

Claims

1. A Chinese medicine composition for treating lung cancer, characterized in that: Its components are ephedra 8-15g, apricot kernel 30-60g, coix seed 60-160g, ophiopogon 15-20g, ginseng 10-30g, yam 60-150g, bupleurum 9-15g, and immature bitter orange 15-30g.

2. The Chinese medicine composition for treating lung cancer according to claim 1, characterized in that: Ephedra 8g, almond 30g, coix seed 60g, Ophiopogon japonicus 15g, ginseng 10g, yam 60g, bupleurum 9g, and Citrus aurantium 15g.

3. A method for preparing a Chinese medicine composition for treating lung cancer as claimed in claim 1 or 2, characterized in that: The following steps are involved: Step 1: Take ephedra, almond, coix seed, ophiopogon japonicus, ginseng, yam, bupleurum, and immature bitter orange, and remove impurities, wash, dry, and sterilize; Step 2: using a pulverizer to coarsely pulverize the Chinese medicine components in sequence to obtain raw material coarse powder; Step 3: Using an ultrafine pulverizer to ultrafinely pulverize the raw material coarse powder in sequence to obtain raw material refined powder; Step 4: Evenly mix the obtained raw material powder according to the component ratio; Step 5: Use 75% alcohol to spray sterilize the mixture described in step 4 for 3 to 5 minutes.

4. A method for preparing a Chinese medicine composition for treating lung cancer as claimed in claim 1, characterized in that: The following steps are involved: Take 8-15g of Chinese herbal medicine ephedra, 30-60g of almond, 60-160g of coix seed, 15-20g of ophiopogon, 10-30g of ginseng, 60-150g of yam, 9-15g of bupleurum and 15-30g of immature bitter orange, add 600-1200ml of pure cold water and soak for 30 minutes, boil in a casserole for 25-40 minutes, pour out the medicine soup, add 300ml of pure cold water and boil, pour out the medicine soup after 15 minutes, and mix the two medicine liquids.

5. Steps for taking Chinese medicine granules: Choose the above-mentioned dosage of Shenwei Pharmaceutical Group Chinese Medicine Granules, Guangdong Yifang Pharmaceutical Co., Ltd. Chinese Medicine Granules, Shijiazhuang Yiling Pharmaceutical Co., Ltd. Chinese Medicine Granules, Beijing Kangrentang Pharmaceutical Co., Ltd. Chinese Medicine Granules and other Chinese medicine granules produced in China. Add 100-300 ml of boiled water to each dose of the above Chinese medicine granules according to the dosage, stir, soak for 10 minutes, and take warm.