Optical index analyzer

Abstract

The present application discloses an optical index analyzer, in which the parameters of the second soft solution unit are different from those of the third soft solution unit; and / or the pH value of the liquid contained in the second soft solution unit is less than the pH value of the liquid contained in the third soft solution unit, and both are not less than 7, or the pH value of the liquid contained in the second soft solution unit is greater than the pH value of the liquid contained in the third soft solution unit, and both are not greater than 7; and / or the HLB value of the liquid contained in the second soft solution unit is less than the HLB value of the liquid contained in the third soft solution unit; and / or the CMC value of the liquid contained in the second soft solution unit is less than the CMC value of the liquid contained in the third soft solution unit. Based on the above method, the reliability of the optical index analyzer can be improved.

Description

Technical Field

[0001] The present application relates to the field of detection technology, and in particular to an optical index analyzer. Background Art

[0002] In the prior art, in an optical indicator analyzer, a corresponding cleaning liquid is usually configured for the sample liquid commonly used for detection, so that after the sample liquid is collected and sampled, the cleaning liquid is used to clean the pipeline through which the sample liquid flows.

[0003] The defect of the prior art is that due to the different sample liquids (such as blood samples) or different application scenarios, the sample liquid usually causes different degrees or different natures of contamination to the pipeline. The cleaning liquid configured in the optical indicator analyzer alone cannot effectively clean the pipeline, that is, the cleaning effect is poor, which makes the reliability of the existing optical indicator analyzer poor. Summary of the invention

[0004] The main technical problem solved by this application is how to improve the reliability of the optical index analyzer.

[0005] In order to solve the above technical problems, the technical solution adopted in the present application is: an optical index analyzer, comprising: at least two test liquid preparation units; a hard solution unit, the hard solution unit is used to destroy the negative pressure maintaining mechanism of the mobile storage unit, collect the sample liquid in the mobile storage unit, transfer the collected sample liquid, and inject the collected sample liquid into at least two test liquid preparation units respectively; a first soft solution unit, the first soft solution unit is connected to the hard solution unit; a first three-way unit, the first end of the first three-way unit is connected to the first soft solution unit; a second soft solution unit, the second soft solution unit is connected to the second end of the first three-way unit; a third soft solution unit, the third soft solution unit is connected to the third end of the first three-way unit; the parameters of the second soft solution unit are different from those of the third soft solution unit, and the parameters include the inner diameter of the tube, the length of the tube and the diameter of the tube. at least one of the materials; and / or, the pH value of the liquid contained in the second soft solution unit is less than the pH value of the liquid contained in the third soft solution unit, and the pH value of the liquid contained in the second soft solution unit and the pH value of the liquid contained in the third soft solution unit are both not less than 7, or, the pH value of the liquid contained in the second soft solution unit is greater than the pH value of the liquid contained in the third soft solution unit, and the pH value of the liquid contained in the second soft solution unit and the pH value of the liquid contained in the third soft solution unit are both not greater than 7; and / or, the HLB value of the liquid contained in the second soft solution unit is less than the HLB value of the liquid contained in the third soft solution unit; and / or, the CMC value of the liquid contained in the second soft solution unit is less than the CMC value of the liquid contained in the third soft solution unit.

[0006] The optical index analyzer further includes: a first fixed liquid storage unit; a second fixed liquid storage unit; the second soft solution unit is connected to the first fixed liquid storage unit, and the second fixed liquid storage unit is not connected to the second soft solution unit, and the second fixed liquid storage unit is not connected to the third soft solution unit; the parameters of the first fixed liquid storage unit are different from those of the second fixed liquid storage unit, and the parameters include at least one of the tube volume and the material; and / or the pH value of the liquid stored in the first fixed liquid storage unit is less than the pH value of the liquid stored in the second fixed liquid storage unit, and the pH value of the liquid stored in the first fixed liquid storage unit is greater than the pH value of the liquid stored in the second fixed liquid storage unit. The pH value of the liquid stored in the fixed liquid storage unit is not less than 7, or the pH value of the liquid stored in the first fixed liquid storage unit is greater than the pH value of the liquid stored in the second fixed liquid storage unit, and the pH value of the liquid stored in the first fixed liquid storage unit and the pH value of the liquid stored in the second fixed liquid storage unit are both not greater than 7; and / or the HLB value of the liquid stored in the first fixed liquid storage unit is less than the HLB value of the liquid stored in the second fixed liquid storage unit; and / or the CMC value of the liquid stored in the first fixed liquid storage unit is less than the CMC value of the liquid stored in the second fixed liquid storage unit.

[0007] Among them, at least two test liquid preparation units are fixed on the same target horizontal line, the target horizontal line extends along the target horizontal direction, the hard solution unit is used to move in the target vertical direction and the target horizontal direction, and the target vertical direction and the target horizontal direction are perpendicular to each other; all units in the optical index analyzer are located in the same accommodating space, the second fixed liquid storage unit is not connected to any of the test liquid preparation units in all the test liquid preparation units, and the second fixed liquid storage unit and at least two test liquid preparation units are located on the same target horizontal line, the second fixed liquid storage unit is located on one side of all the test liquid preparation units, or, all units in the optical index analyzer except the second fixed liquid storage unit are located in a accommodating space, and the second fixed liquid storage unit is located outside the accommodating space; and / or, a recoverable opening cover is provided at the opening of the second fixed liquid storage unit, and the opening on the hard solution unit for collecting sample liquid is located on the side of the hard solution unit.

[0008] Among them, the hard solution unit is used to collect liquid in the second fixed liquid storage unit, transfer the collected liquid in the second fixed liquid storage unit, and inject the collected liquid in the second fixed liquid storage unit into at least two test liquid preparation units respectively; in the process of injecting the collected liquid in the second fixed liquid storage unit into at least two test liquid preparation units respectively, firstly inject the collected liquid in the second fixed liquid storage unit into the test liquid preparation unit containing the hemolytic agent among all the test liquid preparation units; and / or, after collecting the liquid in the second fixed liquid storage unit, make the collected liquid in the second fixed liquid storage unit pass through the first three-way unit back and forth multiple times.

[0009] The optical index analyzer further includes: a first driving unit, the first driving unit is connected to the second soft solution unit; a second driving unit, the second driving unit is connected to the third soft solution unit; and the parameters of the first driving unit are different from those of the second driving unit.

[0010] Among them, the ratio of the capacity of the second drive unit to the first drive unit is greater than or equal to 40 and less than or equal to 120; and / or, the ratio of the capacity of the third soft solution unit to the second drive unit is greater than or equal to 0.3 and less than or equal to 2; and / or, the liquid suction operation of the second fixed liquid storage unit must use the second drive unit.

[0011] Among them, the first three-way unit is one of a three-way valve, a three-way joint and two two-way valves; the optical index analyzer also includes: a first fixed liquid storage unit, the second soft solution unit is connected to the first fixed liquid storage unit; a first drive unit, the first drive unit is connected to the second soft solution unit; a second drive unit, the second drive unit is connected to the third soft solution unit; a second three-way unit, the second three-way unit is one of a three-way joint, a three-way valve, a four-way joint, a four-way valve, two interconnected three-way joints and two interconnected three-way valves; the second three-way unit is respectively connected to the first drive unit, the third soft solution unit and the second drive unit, and the first fixed liquid storage unit is connected to the second drive unit, or the second three-way unit is respectively connected to the first drive unit, the first fixed liquid storage unit, the third soft solution unit and the second drive unit.

[0012] Among them, the optical index analyzer also includes: a first fixed liquid storage unit; a second fixed liquid storage unit; the second soft solution unit is connected to the first fixed liquid storage unit, and the second fixed liquid storage unit is not connected to the second soft solution unit, and the second fixed liquid storage unit is not connected to the third soft solution unit; the maximum time that the liquid in the first fixed liquid storage unit stays in the hard solution unit is greater than the maximum time that the liquid in the second fixed liquid storage unit stays in the hard solution unit; and / or the driving force to which the liquid in the second fixed liquid storage unit is subjected when performing the corresponding cleaning operation is greater than or equal to the driving force to which the liquid in the first fixed liquid storage unit is subjected when performing the corresponding cleaning operation.

[0013] When the hard solution unit collects the sample liquid, the length of the pipeline through which the sample liquid passes is not more than 500 mm and not less than 220 mm, and / or the inner diameter of the pipeline through which the sample liquid passes is not more than 1.2 mm and not less than 0.8 mm.

[0014] Among them, the optical indicator analyzer also includes: a pressure detection unit; a first drive unit, the first drive unit is connected to the second soft solution unit; a second drive unit, the second drive unit is connected to the third soft solution unit; a control unit, the control unit is respectively connected to the pressure detection unit, the first drive unit and the second drive unit; when the hard solution unit collects sample liquid, the pressure detection unit is used to detect the pressure value in the first soft solution unit or the second soft solution unit or the third soft solution unit; the control unit is used to: when the absolute value of the pressure value is detected to be greater than the absolute value of the preset pressure value, control the unit with a larger capacity between the first drive unit and the second drive unit to aspirate and / or spit liquid.

[0015] Wherein, the optical index analyzer also includes: a blood parameter detection unit; a first drive unit, the first drive unit is connected to the second soft solution unit; a second drive unit, the second drive unit is connected to the third soft solution unit; a control unit, the control unit is respectively connected to the blood parameter detection unit, the first drive unit and the second drive unit; when the hard solution unit collects the sample liquid, the blood parameter detection unit is used to detect the blood parameter value in the first soft solution unit; the control unit is used to: when the blood parameter value is detected to be greater than the preset blood parameter value, control the first drive unit and the second drive unit with a larger capacity to aspirate and / or spit liquid; and / or, when the blood parameter value is detected to be greater than the preset blood parameter value, correct the polymerization parameter of the sample liquid based on the blood parameter value; and / or, when the blood parameter value is detected to be greater than the preset blood parameter value, first control the first drive unit and the second drive unit with a larger capacity to aspirate and / or spit liquid, then detect the blood parameter value in the first soft solution unit to obtain the recheck parameter value, and when the recheck parameter value is detected to be greater than the preset blood parameter value, correct the polymerization parameter of the sample liquid based on the blood parameter value and / or the recheck parameter value.

[0016] The beneficial effect of the present application is that, different from the prior art, in the technical solution of the present application, the second soft solution unit and the third soft solution unit are generally used to store or transport different types of cleaning liquids. By connecting the hard solution unit used for dividing samples into at least two test liquid preparation units to the first three-way unit, and then connecting the first three-way unit to the second soft solution unit and the third soft solution unit respectively, when different types of liquids are needed to clean the hard solution unit and its connecting pipeline, different types of liquids are respectively transported to the hard solution unit through the second soft solution unit and the third soft solution unit, that is, the liquid suitable for storage or transportation by the second soft solution unit is transported to the hard solution unit through the second soft solution unit, and the liquid suitable for storage or transportation by the third soft solution unit is transported to the hard solution unit through the third soft solution unit, thereby reducing the possibility of different types of liquids causing damage to the soft solution unit and the hard solution unit that transport these liquids due to their own characteristics. In summary, while reducing the possibility of damage to the pipeline itself, the optical index analyzer can use different types of liquids for cleaning or other operations, thereby improving the reliability of the optical index analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0018] Figure 1 It is a structural schematic diagram of an embodiment of the optical index analyzer of the present application;

[0019] Figure 2 This is one of the schematic diagrams of the use process of one embodiment of the hard solution unit and the second fixed liquid storage unit of the present application;

[0020] Figure 3 This is the second schematic diagram of the use process of one embodiment of the hard solution unit and the second fixed liquid storage unit of the present application;

[0021] Figure 4 It is a structural schematic diagram of another embodiment of the optical index analyzer of the present application.

[0022] Figure numerals: 101, hard solution unit; 1011, collection opening; 102, first soft solution unit; 103, first three-way unit; 104, second soft solution unit; 105, third soft solution unit; 106, first fixed liquid storage unit; 107, second fixed liquid storage unit; 1071, recoverable opening cover; 108, first drive unit; 109, second drive unit; 110, second three-way unit; 1101, first sub-three-way valve; 1102, second sub-three-way valve; 111, cleaning swab. DETAILED DESCRIPTION

[0023] The present application is further described in detail below in conjunction with the accompanying drawings and examples. It is particularly noted that the following examples are only used to illustrate the present application, but are not intended to limit the scope of the present application. Similarly, the following examples are only some embodiments of the present application rather than all embodiments, and all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of the present application.

[0024] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0025] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "install", "set", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or connected through an intermediate medium. For ordinary technicians in this field, the above-mentioned specific meanings belonging to this application can be connected according to specific circumstances.

[0026] This application proposes an optical index analyzer, see Figure 1 , Figure 1 FIG. 1 is a schematic diagram of the structure of an embodiment of the optical index analyzer of the present application. Figure 1 As shown, the optical index analyzer includes at least two test solution preparation units (not shown), a hard solution unit 101 , a first soft solution unit 102 , a first three-way unit 103 , a second soft solution unit 104 and a third soft solution unit 105 .

[0027] The hard solution unit 101 is used to destroy the negative pressure maintaining mechanism of the mobile storage unit, collect the sample liquid in the mobile storage unit, transfer the collected sample liquid, and inject the collected sample liquid into at least two test liquid preparation units respectively. The hard solution unit 101 can be specifically an infusion needle, and a driving force can be provided to the hard solution unit 101 so that the hard solution unit 101 inhales or spits out the sample liquid. For example, a negative pressure driving force can be provided to the hard solution unit 101 so that the hard solution unit 101 collects the sample liquid in the mobile storage unit, and then a positive pressure driving force can be provided to the hard solution unit 101 so that the hard solution unit 101 spits out the collected sample liquid and injects it into the corresponding test liquid preparation unit.

[0028] One end of the first soft solution unit 102 is connected to the hard solution unit 101, the other end of the first soft solution unit 102 is connected to the first end of the first three-way unit 103, the second soft solution unit 104 is connected to the second end of the first three-way unit 103, and the third soft solution unit 105 is connected to the third end of the first three-way unit 103. It should be noted that the second soft solution unit 104 and the third soft solution unit 105 can be respectively provided with corresponding two-way valves, so as to open or disconnect the communication between the second soft solution unit 104 and the third soft solution unit 105 and the first soft solution unit 102 respectively by opening and disconnecting the corresponding two-way valves. For example, when the two-way valve on the second soft solution unit 104 is controlled to be turned on and the two-way valve on the third soft solution unit 105 is turned off, the sample liquid sucked through the hard solution unit 101 can be temporarily stored in the second soft solution unit 104, waiting to be subsequently injected into the corresponding test liquid preparation unit through the hard solution unit 101. Alternatively, when the two-way valve on the second soft solution unit 104 is controlled to be turned off and the two-way valve on the third soft solution unit 105 is controlled to be turned on, the sample liquid sucked through the hard solution unit 101 can be temporarily stored in the third soft solution unit 105, waiting to be subsequently injected into the corresponding test liquid preparation unit through the hard solution unit 101.

[0029] The parameters of the second soft solution unit 104 are different from those of the third soft solution unit 105 , and the parameters include at least one of the inner diameter of the tube, the length of the tube, and the material of the tube.

[0030] And / or, the pH value of the liquid contained in the second soft solution unit 104 is lower than the pH value of the liquid contained in the third soft solution unit 105, and the pH value of the liquid contained in the second soft solution unit 104 and the pH value of the liquid contained in the third soft solution unit 105 are both not lower than 7; or, the pH value of the liquid contained in the second soft solution unit 104 is higher than the pH value of the liquid contained in the third soft solution unit 105, and the pH value of the liquid contained in the second soft solution unit 104 and the pH value of the liquid contained in the third soft solution unit 105 are both not higher than 7.

[0031] And / or, the HLB value of the liquid contained in the second soft solution unit 104 is smaller than the HLB value of the liquid contained in the third soft solution unit 105 .

[0032] And / or, the CMC value of the liquid contained in the second soft solution unit 104 is smaller than the CMC value of the liquid contained in the third soft solution unit 105 .

[0033] Specifically, after the optical index analyzer has collected blood samples, since the blood samples contain a large number of various proteins, such as hemoglobin in red blood cells and various proteins in the nuclei of white blood cells, a cleaning solution with a higher cleaning strength (such as probe liquid) is usually required to clean the various components. The cleaning solution with a higher cleaning strength usually has a stronger oxidizing ability and a stronger surface activity, so the cleaning solution with a higher cleaning strength usually causes corrosion to conventional devices. When the optical index analyzer does not collect blood samples, if cleaning is required, a cleaning solution with a lower cleaning strength can be selected. The cost is lower and can be used in large quantities without causing the total cost to be too high. The cleaning solution with a lower cleaning strength is usually less corrosive.

[0034] In summary, cleaning fluids with lower cleaning intensity can be stored and used for a long time because they are usually less corrosive. Cleaning fluids with higher cleaning intensity are usually more corrosive and volatile. Long-term storage in conventional pipelines can easily lead to aging of conventional components. They can usually only be used for short-term cleaning, and a large number of components are usually cleaned during short-term cleaning. Therefore, components that need to temporarily store cleaning fluids with higher cleaning intensity have stronger corrosion resistance and larger volume.

[0035] Based on the above analysis, it can be known that the characteristics of the two cleaning liquids with stronger cleaning strength and weaker cleaning strength are different. In the technical solution of the present application, different types of cleaning liquids are provided with soft solution units with different characteristics for temporary storage of the cleaning liquids in the following manner, which can effectively reduce the possibility of the above negative problems, as follows:

[0036] First, by making the parameters of the second soft solution unit 104 different from those of the third soft solution unit 105, that is, there is at least one parameter of the inner diameter, length and material of the tube different between the second soft solution unit 104 and the third soft solution unit 105, so that the second soft solution unit 104 and the third soft solution unit 105 can be respectively adapted to store different types of cleaning fluids. For example, the parameters of the second soft solution unit 104 can be more suitable for storing cleaning fluids with lower cleaning intensity, and the parameters of the third soft solution unit 105 can be more suitable for storing cleaning fluids with higher cleaning intensity. For example, the corrosion resistance, inner diameter and length of the tube of the third soft solution unit 105 are greater than those of the second soft solution unit 104. That is, by making the parameters different, the third soft solution unit 105 can have the characteristics of relatively strong corrosion resistance and relatively large volume, so as to meet the needs of components for temporarily storing cleaning fluids with higher cleaning intensity.

[0037] Second, by making the pH value of the liquid contained in the second soft solution unit 104 lower than the pH value of the liquid contained in the third soft solution unit 105, the pH value of the liquid contained in the second soft solution unit 104 and the pH value of the liquid contained in the third soft solution unit 105 are both not lower than 7, so that the second soft solution unit 104 can be used to temporarily store alkaline cleaning solution with weaker alkalinity, while the third soft solution unit 105 can be used to temporarily store alkaline cleaning solution with stronger alkalinity. The cleaning intensity of alkaline cleaning with stronger alkalinity is greater than the cleaning intensity of alkaline cleaning with weaker alkalinity. Therefore, based on this method, the second soft solution unit 104 and the third soft solution unit 105 can each have the ability to temporarily store alkaline cleaning solutions with different cleaning intensities without excessive aging. Alternatively, by making the pH value of the liquid contained in the second soft solution unit 104 greater than the pH value of the liquid contained in the third soft solution unit 105, the pH value of the liquid contained in the second soft solution unit 104 and the pH value of the liquid contained in the third soft solution unit 105 are both no greater than 7, so that the second soft solution unit 104 can be used to temporarily store an acidic cleaning solution with a weaker acidity, while the third soft solution unit 105 can be used to temporarily store an acidic cleaning solution with a stronger acidity. The cleaning intensity of the acidic cleaning with a stronger acidity is greater than the cleaning intensity of the acidic cleaning with a weaker acidity. Therefore, based on this method, the second soft solution unit 104 and the third soft solution unit 105 can each have the ability to temporarily store acidic cleaning solutions with different cleaning intensities without excessive aging. It should be noted that if one of the second soft solution unit 104 and the third soft solution unit 105 stores a liquid with a pH value greater than 7 and the other stores a liquid with a pH value less than 7, it is easy for the alkaline liquid and the acidic liquid to merge in some pipelines or pass through them in sequence, causing acid-base neutralization of at least one of the liquids, thereby reducing its cleaning effect. Therefore, based on the above method, the second soft solution unit 104 and the third soft solution unit 105 can both be used to store acidic liquids, or both be used to store alkaline liquids, thereby avoiding the above-mentioned acid-base neutralization that causes a decrease in cleaning effect, thereby improving the reliability of the optical indicator analyzer.

[0038] Third, by making the HLB value of the liquid contained in the second soft solution unit 104 smaller than the HLB value of the liquid contained in the third soft solution unit 105, the second soft solution unit 104 can be more suitable for temporarily storing liquids with lower water oil content, while the third soft solution unit 105 can be more suitable for temporarily storing liquids with higher water oil content, so as to respectively meet different cleaning requirements. The HLB value (Hydrophile-Lipophile Balance Number), also known as water oil content, is used to indicate the balance between the hydrophilic group and the lipophilic group in the molecule of the liquid as a surfactant. The larger the HLB value, the stronger the hydrophilicity, and the smaller the HLB value, the stronger the lipophilicity. Generally speaking, the HLB value ranges from 1 to 40. It is related to the hydrophilicity and lipophilicity of the surfactant, as well as the basic properties of the surfactant such as surface (interface) tension, adsorption on the interface, emulsification and emulsion stability, dispersibility, solubility, and detergency, and is also related to the application performance of the surfactant. HLB value has important reference value in practical applications. The HLB value of lipophilic surfactants is lower, and the HLB value of hydrophilic surfactants is higher. The HLB value of the hydrophilic-lipophilic turning point is 10. HLB value less than 10 is lipophilic, and HLB value greater than 10 is hydrophilic.

[0039] Fourth, by making the CMC value of the liquid contained in the second soft solution unit 104 smaller than the CMC value of the liquid contained in the third soft solution unit 105, the second soft solution unit 104 can be more suitable for temporarily storing liquids with lower critical micelle concentrations, while the third soft solution unit 105 can be more suitable for temporarily storing liquids with higher critical micelle concentrations, so as to respectively meet different cleaning requirements. The CMC value (Critical Micelle Concentration) refers to the concentration threshold for the liquid as a surfactant to form micelles. At concentrations below the CMC value, the surfactant molecules mainly exist in the form of monomers; at concentrations above the CMC value, micelles are formed, which helps to reduce surface tension, increase interfacial activity and stabilize the effect of dispersing liquids. Different from the prior art, in the technical solution of the present application, the second soft solution unit 104 and the third soft solution unit 105 are generally used to store or transport different types of cleaning liquids. By connecting the hard solution unit 101 used for dispensing to at least two test liquid preparation units through the first soft solution unit 102 to the first three-way unit 103, and then connecting the first three-way unit 103 to the second soft solution unit 104 and the third soft solution unit 105 respectively, when different types of liquids are needed to clean the hard solution unit 101 and its connecting pipelines, different types of liquids can be transported through the second soft solution unit 104 and the third soft solution unit 105 respectively. The liquid suitable for storage or transportation by the second soft solution unit 104 is transported to the hard solution unit 101 through the second soft solution unit 104, while the liquid suitable for storage or transportation by the third soft solution unit 105 is transported to the hard solution unit 101 through the third soft solution unit 105, thereby reducing the possibility of different types of liquids damaging the soft solution unit and the hard solution unit that transport these liquids due to their own characteristics. In summary, while reducing the possibility of damage to the pipeline itself, the optical index analyzer can use different types of liquids for cleaning or other operations, thereby improving the reliability of the optical index analyzer.

[0040] In one embodiment, if Figure 1 As shown, the optical index analyzer may further include a first fixed liquid storage unit 106 and a second fixed liquid storage unit 107 .

[0041] The second soft solution unit 104 is connected to the first fixed liquid storage unit 106 , and the second fixed liquid storage unit 107 is not connected to the second soft solution unit 104 , and the second fixed liquid storage unit 107 is not connected to the third soft solution unit 105 .

[0042] The parameters of the first fixed liquid storage unit 106 are different from the parameters of the second fixed liquid storage unit 107 , and the parameters include at least one of volume and material.

[0043] And / or, the pH value of the liquid stored in the first fixed liquid storage unit 106 is lower than the pH value of the liquid stored in the second fixed liquid storage unit 107, and the pH value of the liquid stored in the first fixed liquid storage unit 106 and the pH value of the liquid stored in the second fixed liquid storage unit 107 are both not less than 7; or, the pH value of the liquid stored in the first fixed liquid storage unit 106 is higher than the pH value of the liquid stored in the second fixed liquid storage unit 107, and the pH value of the liquid stored in the first fixed liquid storage unit 106 and the pH value of the liquid stored in the second fixed liquid storage unit 107 are both not greater than 7.

[0044] And / or, the HLB value of the liquid stored in the first fixed liquid storage unit 106 is smaller than the HLB value of the liquid stored in the second fixed liquid storage unit 107 .

[0045] And / or, the CMC value of the liquid stored in the first fixed liquid storage unit 106 is smaller than the CMC value of the liquid stored in the second fixed liquid storage unit 107 .

[0046] Specifically, the first fixed liquid storage unit 106 can be used to store cleaning liquid with lower cleaning strength, such as diluent or ordinary cleaning liquid, and the second fixed liquid storage unit 107 can be used to store cleaning liquid with higher cleaning strength, such as probe liquid.

[0047] The first fixed liquid storage unit 106 can be connected to the second soft solution unit 104 through corresponding pipelines and corresponding two-way valves. When necessary, the pipeline between the first fixed liquid storage unit 106 and the second soft solution unit 104 can be opened, and the liquid stored in the first fixed liquid storage unit 106 can be transported to the second soft solution unit 104 for temporary storage in preparation for subsequent operations.

[0048] The second fixed liquid storage unit 107 may be disconnected from the second soft solution unit 104 and the third soft solution unit 105 under normal conditions. When necessary, the hard solution unit 101 may be controlled to extend into the second fixed liquid storage unit 107 to achieve temporary connection between the hard solution unit 101 and the second fixed liquid storage unit 107, thereby transferring the liquid stored in the second fixed liquid storage unit 107 to the third soft solution unit 105 for temporary storage in preparation for subsequent operations.

[0049] In the technical solution of the present application, based on the above-mentioned configuration of the first fixed liquid storage unit 106 and the second fixed liquid storage unit 107, fixed liquid storage units with different characteristics can be provided for different types of cleaning liquids to store the cleaning liquids, as follows:

[0050] First, by making the parameters of the first fixed liquid storage unit 106 different from those of the second fixed liquid storage unit 107, that is, there is a difference in at least one parameter of volume and material between the first fixed liquid storage unit 106 and the second fixed liquid storage unit 107, so that the first fixed liquid storage unit 106 and the second fixed liquid storage unit 107 can be respectively adapted to store different types of cleaning liquids. For example, the parameters of the first fixed liquid storage unit 106 can be more suitable for storing cleaning liquids with lower cleaning intensity, and the parameters of the second fixed liquid storage unit 107 can be more suitable for storing cleaning liquids with higher cleaning intensity. For example, the corrosion resistance and volume of the material of the second fixed liquid storage unit 107 are greater than those of the first fixed liquid storage unit 106. That is, by making the parameters different, the second fixed liquid storage unit 107 can have the characteristics of relatively strong corrosion resistance and relatively large volume to meet the needs of components for storing cleaning liquids with higher cleaning intensity.

[0051] Second, by making the pH value of the liquid contained in the first fixed liquid storage unit 106 lower than the pH value of the liquid contained in the second fixed liquid storage unit 107, the pH value of the liquid contained in the first fixed liquid storage unit 106 and the pH value of the liquid contained in the second fixed liquid storage unit 107 are both not less than 7, so that the first fixed liquid storage unit 106 can be used to store alkaline cleaning liquid with weaker alkalinity, while the second fixed liquid storage unit 107 can be used to store alkaline cleaning liquid with stronger alkalinity. The cleaning intensity of alkaline cleaning with stronger alkalinity is greater than the cleaning intensity of alkaline cleaning with weaker alkalinity. Therefore, based on this method, the first fixed liquid storage unit 106 and the second fixed liquid storage unit 107 can each have the ability to adapt to storing alkaline cleaning liquids of different cleaning intensities without excessive aging. Alternatively, by making the pH value of the liquid contained in the first fixed liquid storage unit 106 greater than the pH value of the liquid contained in the second fixed liquid storage unit 107, the pH value of the liquid contained in the first fixed liquid storage unit 106 and the pH value of the liquid contained in the second fixed liquid storage unit 107 are both no greater than 7, so that the first fixed liquid storage unit 106 can be used to store an acidic cleaning solution with a weaker acidity, while the second fixed liquid storage unit 107 can be used to store an acidic cleaning solution with a stronger acidity, and the cleaning intensity of the acidic cleaning with a stronger acidity is greater than the cleaning intensity of the acidic cleaning with a weaker acidity. Therefore, based on this method, the first fixed liquid storage unit 106 and the second fixed liquid storage unit 107 can each have the ability to adapt to storing acidic cleaning solutions of different cleaning intensities without excessive aging.

[0052] If the pH values ​​of the liquids stored in the first fixed liquid storage unit 106 and the second fixed liquid storage unit 107 are one acid and one alkaline, as described above, after entering the second soft solution unit 104 and the third soft solution unit 105 respectively, they will converge in some pipelines or pass through them in sequence, causing acid-base neutralization of at least one of the liquids, which will weaken the cleaning effect.

[0053] Third, by making the HLB value of the liquid contained in the first fixed liquid storage unit 106 smaller than the HLB value of the liquid contained in the second fixed liquid storage unit 107, the first fixed liquid storage unit 106 can be more suitable for storing liquids with lower water-oil content, while the second fixed liquid storage unit 107 can be more suitable for storing liquids with higher water-oil content, so as to respectively meet different cleaning needs. The HLB value (Hydrophile-Lipophile Balance Number), also known as water-oil content, is used to represent the balance between the hydrophilic group and the lipophilic group in the molecule of the liquid as a surfactant. The larger the HLB value, the stronger the hydrophilicity, and the smaller the HLB value, the stronger the lipophilicity. Generally speaking, the HLB value ranges from 1 to 40. It is related to the hydrophilicity and lipophilicity of the surfactant, as well as the basic properties of the surfactant such as surface (interface) tension, adsorption on the interface, emulsification and emulsion stability, dispersibility, solubility, and detergency, and is also related to the application performance of the surfactant. The HLB value has an important reference value in practical applications. The HLB value of lipophilic surfactants is lower, and the HLB value of hydrophilic surfactants is higher. The HLB value of the hydrophilic-lipophilic turning point is 10. An HLB value less than 10 is lipophilic, and an HLB value greater than 10 is hydrophilic. Fourth, by making the CMC value of the liquid contained in the first fixed liquid storage unit 106 smaller than the CMC value of the liquid contained in the second fixed liquid storage unit 107, the first fixed liquid storage unit 106 can be more suitable for storing liquids with lower critical micelle concentrations, and the second fixed liquid storage unit 107 can be more suitable for storing liquids with higher critical micelle concentrations, so as to meet different cleaning needs respectively. The CMC value (Critical Micelle Concentration) refers to the concentration threshold value for the liquid as a surfactant to form micelles. At a concentration lower than the CMC value, the surfactant molecules mainly exist in the form of monomers; at a concentration higher than the CMC value, micelles are formed, which helps to reduce surface tension, increase interfacial activity and stabilize the effect of dispersing liquids.

[0054] Hydrophilicity and hydrophobicity: Surfactants are composed of hydrophilic groups and hydrophobic groups, and the relative proportion of these two groups affects the performance of the surfactant. The hydrophilic groups of hydrophilic surfactant molecules are dominant, while the opposite is true for hydrophobic surfactants. Based on the above approach, a more suitable liquid storage unit with different characteristics can be provided for different types of liquids, reducing the possibility of damage to the liquid storage unit caused by the liquid, and improving the reliability of the optical indicator analyzer.

[0055] Optionally, at least two test liquid preparation units are fixed on the same target horizontal line, the target horizontal line extends along the target horizontal direction, and the hard solution unit 101 is used to move in the target vertical direction and the target horizontal direction, and the target vertical direction and the target horizontal direction are perpendicular to each other.

[0056] All units in the optical index analyzer are located in the same storage space, the second fixed liquid storage unit 107 is not connected to any of the test liquid preparation units, and the second fixed liquid storage unit 107 and at least two test liquid preparation units are located on the same target horizontal line, the second fixed liquid storage unit 107 is located on one side of all the test liquid preparation units, or, all units in the optical index analyzer except the second fixed liquid storage unit 107 are located in a storage space, and the second fixed liquid storage unit 107 is located outside the storage space.

[0057] And / or, a recoverable opening cover is provided at the opening of the second fixed liquid storage unit 107 , and the opening on the hard solution unit 101 for collecting the sample liquid is located on the side of the hard solution unit 101 .

[0058] Specifically, first, the test liquid preparation unit can specifically refer to a reaction pool. When separating blood, it is usually necessary to control the hard solution unit 101 to inject the collected blood samples into each reaction pool respectively, so as to perform corresponding processing to obtain the test liquid, and then perform sample testing on each test liquid respectively, obtain the test results, and realize sample testing. In addition, when cleaning, it is also usually necessary to control the hard solution unit 101 to inject the collected cleaning liquid (such as probe liquid) into each reaction pool respectively, so as to perform corresponding cleaning.

[0059] By fixing at least two test liquid preparation units on the same target horizontal line, the target horizontal line extends along the target horizontal direction, and the hard solution unit 101 is used to move in the target vertical direction and the target horizontal direction, and the target vertical direction and the target horizontal direction are perpendicular to each other, the lower needle ports of the hard solution unit 101 on each test liquid preparation unit can be located on the same horizontal line, that is, after controlling the hard solution unit 101 to descend to a certain horizontal height, only one motor is used to control the hard solution unit 101 to move in a direction parallel to the target horizontal line, so that it can be moved to the lower needle port positions of different test liquid preparation units for respectively injecting liquids, thereby improving the efficiency of blood separation or cleaning liquid separation, reducing the possibility of negative effects caused by excessively long separation time of blood samples or probe liquids, and improving the efficiency and reliability of liquid separation.

[0060] Second, in one example, all units in the optical index analyzer are located in the same accommodation space, the second fixed liquid storage unit 107 is not connected to any of the test liquid preparation units, and the second fixed liquid storage unit 107 and at least two test liquid preparation units are located on the same target horizontal line, and the second fixed liquid storage unit 107 is located on one side of all the test liquid preparation units. By fixing the second fixed liquid storage unit 107 and at least two test liquid preparation units on the same target horizontal line, the target horizontal line extends along the target horizontal direction, and the hard solution unit 101 is used to move in the target vertical direction and the target horizontal direction, and the target vertical direction and the target horizontal direction are perpendicular to each other, so that the hard solution unit 101 can be located on the same horizontal line with the lower needle port on the second fixed liquid storage unit 107 and each test liquid preparation unit. That is, after the hard solution unit 101 is controlled to descend to a certain horizontal height, only one motor is used to control the hard solution unit 101 to move in a direction parallel to the target horizontal line, so that it can be moved to the lower needle port positions of the second fixed liquid storage unit 107 and different test liquid preparation units respectively, so as to respectively aspirate (for the second fixed liquid storage unit 107) or inject (for the test liquid preparation unit), thereby improving the efficiency of blood separation or cleaning liquid separation, reducing the possibility of negative effects caused by excessive separation time of blood samples or probe liquid, and improving the efficiency and reliability of separation. In addition, when the optical indicator analyzer is testing samples in batches, the liquid in the second fixed liquid storage unit 107 is generally not sucked for strong cleaning. This type of strong cleaning is an extremely low-frequency operation. Therefore, the second fixed liquid storage unit 107 is set to be located on one side of all the test liquid preparation units (such as the front side or the back side, the best option is to set it on the back side). Only when it is extremely necessary, the hard solution unit 101 is driven to control the side of all the test liquid preparation units to suck liquid for strong cleaning. In this way, when testing samples in batches, the speed is optimized due to the short motion path and the fluctuation of the start and stop speed of the motor, which greatly improves the speed of batch testing of samples.

[0061] In another example, all units in the optical index analyzer except the second fixed liquid storage unit 107 are located in a storage space, and the second fixed liquid storage unit 107 is located outside the storage space, or even completely independent of the optical index analyzer. Probe liquid or other liquids with strong cleaning strength can be stored in the second fixed liquid storage unit 107, and only when collection is needed, the hard solution unit 101 is controlled to extend into the second fixed liquid storage unit 107 outside the storage space to collect the cleaning liquid therein for subsequent operations. Since the second fixed liquid storage unit 107 is located outside the storage space, it is also convenient for technicians to replace or replenish the liquid at any time, and it is very convenient to use.

[0062] Third, by providing a recoverable opening cover at the opening of the second fixed liquid storage unit 107, the opening on the hard solution unit 101 for collecting the sample liquid is located on the side of the hard solution unit 101, and the second fixed liquid storage unit 107 can be opened by controlling the bottom end of the hard solution unit 101 to abut against the recoverable opening cover. After the hard solution unit 101 is inserted into the second fixed liquid storage unit 107, the liquid in the second fixed liquid storage unit 107 is collected through the opening on the side of the hard solution unit 101 to prepare for subsequent operations. Subsequently, only the hard solution unit 101 needs to be removed from the second fixed liquid storage unit 107. , that is, the recoverable opening cover can automatically restore and close the second fixed liquid storage unit 107. Compared with the traditional technology of controlling the hard solution unit 101 of the puncture needle to puncture the rubber bottle cap of the second fixed liquid storage unit 107 to collect liquid, based on this method, the generation of rubber particles caused by puncture can be avoided, thereby avoiding the possibility of rubber particles falling into the liquid storage unit and contaminating the liquid. It can also avoid the situation where the second fixed liquid storage unit 107 has irreversible normally open holes due to too many punctures, further reducing the possibility of liquid in the second fixed liquid storage unit 107 being contaminated. In addition, the liquid in the second fixed liquid storage unit 107 may be highly volatile, and the recoverable opening cover can automatically close the opening of the second fixed liquid storage unit 107 after the hard solution unit leaves, greatly reducing the volatilization of the liquid therein.

[0063] Alternatively, see Figure 2 and Figure 3 , Figure 2 This is one of the schematic diagrams of the use process of an embodiment of the hard solution unit 101 and the second fixed liquid storage unit 107 of the present application. Figure 3 This is the second schematic diagram of the use process of an embodiment of the hard solution unit 101 and the second fixed liquid storage unit 107 of the present application.

[0064] like Figure 2 and Figure 3 As shown, the hard solution unit 101 is used to collect liquid in the second fixed liquid storage unit 107, transfer the collected liquid in the second fixed liquid storage unit 107, and inject the collected liquid in the second fixed liquid storage unit 107 into at least two test liquid preparation units respectively.

[0065] In the process of injecting the collected liquid in the second fixed liquid storage unit 107 into at least two test liquid preparation units respectively, the collected liquid in the second fixed liquid storage unit 107 is first injected into the test liquid preparation unit containing the hemolytic agent among all the test liquid preparation units.

[0066] And / or, after collecting the liquid in the second fixed liquid storage unit 107 , the collected liquid in the second fixed liquid storage unit 107 is passed through the first three-way unit 103 multiple times.

[0067] Specifically, after collecting the liquid in the second fixed liquid storage unit 107, such as the probe liquid, the liquid can be injected into at least two test liquid preparation units respectively for subsequent cleaning of the test liquid preparation units. In this process, there may be the following two examples:

[0068] In the first example, before the collected liquid in the second fixed liquid storage unit 107 is injected into all the test liquid preparation units, the test liquid preparation units containing hemolytic agent among all the test liquid preparation units can be determined first. Since the hemolytic agent will dissolve the protein in the blood sample, the protein is easy to adhere to the pipeline device, and the amount of blood sample in the test liquid preparation unit containing the hemolytic agent is usually relatively large, therefore, the collected liquid in the second fixed liquid storage unit 107 can be first injected into the test liquid preparation unit containing the hemolytic agent among all the test liquid preparation units, and then the collected liquid in the second fixed liquid storage unit 107 can be injected into the test liquid preparation unit that does not contain the hemolytic agent among all the test liquid preparation units, so that the test liquid preparation unit containing the hemolytic agent can have more immersion time in the liquid in the second fixed liquid storage unit 107 than the test liquid preparation unit not containing the hemolytic agent, thereby enhancing the cleaning effect of the test liquid preparation unit containing the hemolytic agent.

[0069] In the second example, after collecting the liquid in the second fixed liquid storage unit 107, the collected liquid in the second fixed liquid storage unit 107 can be passed back and forth through the first three-way unit 103 multiple times. Based on this method, the cleaning effect of the liquid in the second fixed liquid storage unit 107 on the blood sample remaining in the first three-way unit 103 itself and the pipes connected thereto can be effectively improved.

[0070] In one embodiment, if Figure 1 As shown, the optical index analyzer includes a first driving unit 108 and a second driving unit 109 .

[0071] The first driving unit 108 is connected to the second soft solution unit 104 .

[0072] The second driving unit 109 is connected to the third soft solution unit 105 .

[0073] The parameters of the first driving unit 108 are different from the parameters of the second driving unit 109 .

[0074] Specifically, the parameters of the drive unit may specifically refer to capacity, gear, thrust, motor power and other parameters, which are not limited here.

[0075] For example, the first fixed liquid storage unit 106 is used to store a diluent or a common cleaning solution, and the second fixed liquid storage unit 107 is used to store a probe liquid.

[0076] When using probe liquid, a relatively large amount is usually required, and more places need to be cleaned. For example, wherever a blood sample is passed, there may be residual protein in the blood, which requires cleaning with the probe liquid. Therefore, the volume of the second drive unit 109 can be made larger than the volume of the first drive unit 108. The second drive unit 109 can be controlled to absorb the liquid stored in the second fixed liquid storage unit 107 through the third soft solution unit 105, and the first drive unit 108 can be controlled to absorb the liquid stored in the first fixed liquid storage unit 106 through the second soft solution unit 104, so that each drive unit is more suitable for the liquid to be transported.

[0077] Based on the above method, the parameters of different driving units can be differentiated so that different driving units are more suitable for the characteristic requirements of conveying corresponding liquids, thereby improving the reliability of the optical index analyzer.

[0078] Optionally, a ratio of the capacity of the second drive unit 109 to that of the first drive unit 108 is greater than or equal to 40 and less than or equal to 120.

[0079] Optionally, when there is no sample in the hard solution unit 101 and the pipeline connected thereto, the second driving unit 109 is used to aspirate liquid (the second driving unit 109 and the first driving unit 108 may be used to aspirate liquid at the same time, or only the second driving unit 109 may be used to aspirate liquid, but not only the first driving unit 108), so as to collect the sample through the hard solution unit 101. Since the capacity of the second driving unit 109 is relatively large, the efficiency of the collection operation can be effectively improved.

[0080] Optionally, when there is a sample in the hard solution unit 101 and the pipeline connected thereto, only the first driving unit 108 is used to discharge liquid, so as to perform a sample separation operation on the sample liquid through the hard solution unit 101. For example, the suction and discharge accuracy of a plunger pump is generally a fixed percentage of its capacity (e.g., ±1%). Since the capacity of the first driving unit 108 is relatively small, and compared with the second driving unit 109, its capacity differs by a maximum of 2 orders of magnitude, which means that the accuracy of its sample separation operation can also be improved by nearly 2 orders of magnitude compared with the accuracy of the second driving unit 109. Therefore, using only the first driving unit 108 for sample separation can effectively improve the accuracy of the sample separation operation.

[0081] Optionally, the ratio of the capacity of the third soft solution unit 105 to that of the second drive unit 109 is greater than or equal to 0.3 and less than or equal to 2. The liquid in the third soft solution unit 105 is used for strong cleaning and is highly corrosive and not suitable for long-term storage. Therefore, its capacity is basically equivalent to the amount of liquid used for one strong cleaning. If the capacity of the second drive unit 109 is selected to be larger, the driving suction capacity is stronger and the cleaning efficiency is higher. If the capacity of the second drive unit 109 is selected to be slightly smaller and the allocated liquid is more precise, then high cleaning efficiency can be ensured while saving strong cleaning liquid, which is beneficial to reducing cleaning costs.

[0082] Optionally, the second fixed liquid storage unit 107 must use the second driving unit 109 for the liquid suction operation. Since the capacity of the second driving unit 109 is much larger than that of the first driving unit 108, the driving suction capacity is stronger and the cleaning efficiency is higher, thereby reducing corrosion to the pipeline.

[0083] Specifically, in one example, in a single sample test, except for the polymerization parameter test (such as the erythrocyte sedimentation rate (Erythrocyte Sedimentation Rate) parameter test), the amount of blood sample required for the test can usually be 40 microliters, of which 35 microliters can be used for routine blood tests, and the capacity of the first drive unit 108 is less than or equal to 120 microliters. The first drive unit 108 in this example can be used to perform sample splitting operations on the collected blood samples. In addition, the amount of blood sample required for polymerization parameter testing is usually 140 microliters, and usually a blood sample of the sum of 140 microliters and 40 microliters is sucked in, and a total of 20 microliters of blood samples at the head and tail ends are discarded, and 160 microliters of blood samples are used to perform polymerization parameter testing, as well as sample splitting operations for routine blood tests or other tests.

[0084] In another example, the capacity of the first driving unit 108 may be less than or equal to 250 μL, for example, 250 μL. The first driving unit 108 in this example may be used to perform sample separation operations on the collected blood samples and as a driving source for flow-type sheath fluid auxiliary propulsion, which is not limited here.

[0085] Based on the above manner, the second driving unit 109 is used to aspirate liquid so as to collect blood samples through the hard solution unit 101. Since the capacity of the second driving unit 109 is relatively large, the efficiency of the collection operation can be effectively improved.

[0086] The first driving unit 108 is used to discharge liquid, so as to perform a sample separation operation on the blood sample through the hard solution unit 101. Since the capacity of the first driving unit 108 is relatively small, the accuracy of the sample separation operation can be effectively improved.

[0087] Alternatively, see Figure 4 , Figure 4 FIG. 1 is a schematic diagram of the structure of another embodiment of the optical index analyzer of the present application. Figure 1 and Figure 4 As shown, the optical index analyzer may further include a cleaning swab 111 , and the cleaning swab 111 is used to be sleeved on the hard solution unit 101 to clean the outer wall of the hard solution unit 101 .

[0088] Specifically, in practice, the capacity of the second driving unit 109 is greater than the capacity of the first driving unit 108 .

[0089] The cleaning swab 111 may have a liquid inlet and a liquid outlet. The liquid inlet may be connected to the second drive unit 109 via a corresponding two-way valve, and the liquid outlet may be connected to a waste liquid pool. For example, the inhaled diluent may be input through the liquid inlet via the second drive unit 109 so that the diluent cleans the outer wall of the hard solution unit 101, and then the cleaned waste liquid is output through the liquid outlet and discharged into the waste liquid pool or other types of waste liquid channels to complete the cleaning.

[0090] Based on the above manner, since the capacity of the second driving unit 109 is relatively large, the cleaning effect of the cleaning swab 111 can be improved, and the cleaning efficiency can be improved.

[0091] In one embodiment, if Figure 1 and Figure 4 As shown, the first three-way unit 103 is one of a three-way valve, a three-way connector and two two-way valves.

[0092] The optical index analyzer includes a first fixed liquid storage unit 106 , a first driving unit 108 , a second driving unit 109 and a second three-way unit 110 .

[0093] The second soft solution unit 104 is connected to the first fixed liquid storage unit 106, the first driving unit 108 is connected to the second soft solution unit 104, and the second driving unit 109 is connected to the third soft solution unit 105. The connection may be a direct connection or an indirect connection, and the connected pipeline may be connected or disconnected when needed, which is not limited here.

[0094] The second three-way unit 110 is one of a three-way connector, a three-way valve, a four-way connector, a four-way valve, two three-way connectors connected to each other, and two three-way valves connected to each other.

[0095] Among them, the second three-way unit 110 is respectively connected to the first driving unit 108, the third soft solution unit 105 and the second driving unit 109, and the first fixed liquid storage unit 106 is connected to the second driving unit 109, or the second three-way unit 110 is respectively connected to the first driving unit 108, the first fixed liquid storage unit 106, the third soft solution unit 105 and the second driving unit 109.

[0096] Specifically, the first fixed liquid storage unit 106 is used to store diluent or common cleaning liquid, and the second fixed liquid storage unit 107 can be used to store probe liquid.

[0097] In one example, if Figure 4 As shown, the second three-way unit 110 is a three-way valve, the common port of the three-way valve is connected to the first port of the second driving unit 109, the first branch port of the three-way valve is connected to the first driving unit 108, the second branch port of the three-way valve is connected to the third soft solution unit 105, and the second port of the second driving unit 109 is connected to the first fixed liquid storage unit 106.

[0098] Based on this structure, if it is necessary to use the liquid in the first fixed liquid storage unit 106, the two-way valve on the pipeline connecting the second port of the second drive unit 109 to the first fixed liquid storage unit 106 can be controlled to open to absorb the liquid in the first fixed liquid storage unit 106, and then the two-way valve on the pipeline connecting the second port of the second drive unit 109 to the first fixed liquid storage unit 106 can be controlled to close, and the common port of the three-way valve is controlled to connect to the first branch port, and the second drive unit 109 is controlled to transport the absorbed liquid to the first drive unit 108, and then the common port of the three-way valve is controlled to connect to the second branch port, and the first drive unit 108 is controlled to transport the absorbed liquid to the second soft solution unit 104 for temporary storage for subsequent use.

[0099] If it is necessary to use the liquid in the second fixed liquid storage unit 107, the two-way valve on the pipeline connecting the second port of the second driving unit 109 to the first fixed liquid storage unit 106 can be closed, and the common port of the three-way valve can be connected to the second branch port, and the hard solution unit 101 can be controlled to extend into the second fixed liquid storage unit 107, and then the second driving unit 109 can be controlled to absorb the liquid stored in the second fixed liquid storage unit 107, so that the liquid is transported to the third soft solution unit 105 for temporary storage for subsequent use.

[0100] In another example, the second three-way unit 110 is a four-way connector or a four-way valve or a connector with four ports formed by two three-way connectors or two three-way valves, such as Figure 1As shown, the second three-way unit 110 can also include a first sub-three-way valve 1101 and a second sub-three-way valve 1102, the first branch port of the first sub-three-way valve 1101 is connected to the first driving unit 108, the second branch port of the first sub-three-way valve 1101 is connected to the third soft solution unit 105, the first branch port of the second sub-three-way valve 1102 is connected to the common port of the first sub-three-way valve 1101, the second branch port of the second sub-three-way valve 1102 is connected to the first fixed liquid storage unit 106, and the common port of the second sub-three-way valve 1102 is connected to the second driving unit 109.

[0101] Based on this structure, as in the previous embodiment, by reasonably controlling the opening and closing of each three-way valve, when necessary, the liquid in the first fixed liquid storage unit 106 can be transported to the second soft solution unit 104 for temporary storage for subsequent use, or the liquid in the second fixed liquid storage unit 107 can be transported to the third soft solution unit 105 for temporary storage for subsequent use.

[0102] Based on the above method, the use flexibility of the optical index analyzer can be improved.

[0103] In one embodiment, the optical index analyzer further includes a first fixed liquid storage unit 106 and a second fixed liquid storage unit 107 .

[0104] The second soft solution unit 104 is connected to the first fixed liquid storage unit 106 , and the second fixed liquid storage unit 107 is not connected to the second soft solution unit 104 , and the second fixed liquid storage unit 107 is not connected to the third soft solution unit 105 .

[0105] The maximum time that the liquid in the first fixed liquid storage unit 106 stays in the hard solution unit 101 is greater than the maximum time that the liquid in the second fixed liquid storage unit 107 stays in the hard solution unit 101 .

[0106] And / or, the driving force to which the liquid in the second fixed liquid storage unit 107 is subjected during the corresponding cleaning operation is greater than or equal to the driving force to which the liquid in the first fixed liquid storage unit 106 is subjected during the corresponding cleaning operation.

[0107] Specifically, the first fixed liquid storage unit 106 is used to store diluent or common cleaning liquid, and the second fixed liquid storage unit 107 can be used to store probe liquid.

[0108] Since the diluent or ordinary cleaning fluid is less corrosive, while the probe fluid is more corrosive, by making the maximum length of time that the liquid in the first fixed liquid storage unit 106 stays in the hard solution unit 101 longer than the maximum length of time that the liquid in the second fixed liquid storage unit 107 stays in the hard solution unit 101, the damage caused by the probe fluid to the hard solution unit 101 can be effectively reduced, thereby improving the reliability of the optical index analyzer.

[0109] Since the optical indicator analyzer usually needs to be thoroughly cleaned when the probe liquid is used for cleaning, the driving force can be made greater when the probe liquid is used for cleaning than when the diluent or ordinary cleaning liquid is used for cleaning. This can improve the cleaning effect of the probe liquid when cleaning, and can also improve the efficiency of the probe liquid when cleaning, thereby reducing the possibility of damage to the pipeline and improving the reliability of the optical indicator analyzer.

[0110] In one embodiment, when the hard solution unit 101 collects the sample liquid, the length of the pipe through which the sample liquid passes is not greater than 500 mm and not less than 220 mm, and / or the inner diameter of the pipe through which the sample liquid passes is not greater than 1.2 mm and not less than 0.8 mm.

[0111] Specifically, by ensuring that the length of the pipeline through which the collected sample liquid, such as a blood sample, passes is not greater than 500 mm and not less than 220 mm, and / or the inner diameter of the pipeline is not greater than 1.2 mm and not less than 0.8 mm, the pipeline for temporarily storing the blood sample can have a sufficiently large volume to store the blood sample, and can also reduce the surface area of ​​the inner wall of the pipeline as much as possible at the same volume, thereby reducing the surface area where the blood sample may remain, thereby reducing the area that needs to be cleaned, increasing the difficulty of subsequent cleaning of the pipeline, and improving the cleaning effect.

[0112] The pipeline through which the sample solution passes may specifically include at least part of the first soft solution unit 102 , the first three-way unit 103 , the second soft solution unit 104 and the third soft solution unit 105 .

[0113] In one embodiment, the optical index analyzer further includes a pressure detection unit, a first driving unit 108 , a second driving unit 109 and a control unit.

[0114] The first driving unit 108 is connected to the second soft solution unit 104 .

[0115] The second driving unit 109 is connected to the third soft solution unit 105 .

[0116] The control unit is connected to the pressure detection unit, the first driving unit 108 and the second driving unit 109 respectively.

[0117] When the hard solution unit 101 collects the sample liquid, the pressure detection unit is used to detect the pressure value in the first soft solution unit 102 or the second soft solution unit 104 or the third soft solution unit 105 .

[0118] The control unit is used to control the first driving unit 108 and the second driving unit 109 with a larger capacity to suck and / or discharge liquid when it is detected that the absolute value of the pressure value is greater than the absolute value of the preset pressure value.

[0119] Specifically, when controlling the hard solution unit 101 to collect the sample liquid, if it is detected that the absolute value of the pressure value in the pipeline directly or indirectly connected to the hard solution unit 101 is greater than the absolute value of the preset pressure value, it can be determined that there may be a blockage in the pipeline at this time, causing the pressure in the pipeline to be too high. For example:

[0120] First, when the driving unit is aspirating liquid to suck in the sample liquid, the pressure value in the pipeline is a negative pressure value. If the pipeline is blocked, it is easy to cause the absolute value of the negative pressure value to increase relative to the normal state. When it is detected that the absolute value of the negative pressure value is greater than the absolute value of the preset pressure value, it can be determined that a blockage exists at this time. Then, the first driving unit 108 and the second driving unit 109 with a larger capacity can be controlled to aspirate liquid, so as to clear the blocked pipeline with a larger liquid driving force, and the blockage can be pushed or loosened by the suction and spitting action, so as to restore the blockage.

[0121] Similarly, secondly, when the driving unit sucks liquid to spit out the sample liquid, the pressure value in the pipeline is a positive pressure value. If the pipeline is blocked, it is easy to cause the absolute value of the positive pressure value to rise relative to the normal state. When it is detected that the absolute value of the positive pressure value is greater than the absolute value of the preset pressure value, it can be determined that a blockage exists at this time, and the first driving unit 108 and the second driving unit 109 with a larger capacity can be controlled to suck liquid, so as to clear the blocked pipeline with a larger liquid driving force, and the blockage can be pushed or loosened by the suction and spitting action, so as to promote the restoration of the blockage.

[0122] Based on the above method, when it is determined that there is a blockage in the pipeline, the driving force on the liquid in the pipeline can be increased, the negative impact caused by the pipeline blockage can be reduced or eliminated, and the reliability of the optical indicator analyzer can be improved.

[0123] In one embodiment, the optical index analyzer further includes a blood parameter detection unit, a first driving unit 108 , a second driving unit 109 and a control unit.

[0124] The first driving unit 108 is connected to the second soft solution unit 104 .

[0125] The second driving unit 109 is connected to the third soft solution unit 105 .

[0126] The control unit is connected to the blood parameter detection unit, the first driving unit 108 and the second driving unit 109 respectively.

[0127] When the hard solution unit 101 collects the sample liquid, the blood parameter detection unit is used to detect the blood parameter value in the first soft solution unit 102 .

[0128] The control unit is used for:

[0129] When it is detected that the blood parameter value is greater than the preset blood parameter value, the first driving unit 108 and the second driving unit 109 whichever has a larger capacity is controlled to aspirate and / or discharge liquid.

[0130] and / or, when it is detected that the blood parameter value is greater than a preset blood parameter value, the polymerization parameter of the sample liquid is corrected based on the blood parameter value;

[0131] And / or, when it is detected that the blood parameter value is greater than the preset blood parameter value, first control the unit with a larger capacity among the first drive unit 108 and the second drive unit 109 to aspirate and / or discharge liquid, and then detect the blood parameter value in the first soft solution unit 102 to obtain the review parameter value, and when it is detected that the review parameter value is greater than the preset blood parameter value, the polymerization parameter of the sample liquid is corrected based on the blood parameter value and / or the review parameter value.

[0132] Specifically, the above blood parameter value may specifically refer to the packed cell volume (PCV), also known as the hematocrit (HCT), which refers to the volume ratio of the sunken red blood cells to the whole blood after a certain amount of anticoagulated whole blood is centrifuged and precipitated. It is a simple method to indirectly reflect the number and volume of red blood cells. Combined with the red blood cell count and hemoglobin content, the average red blood cell value can be calculated, which is helpful for the morphological classification of anemia.

[0133] In the first case, when a blood parameter value is detected to be greater than a preset blood parameter value, it may be because the blood sample used as the sample liquid has an aggregation parameter (such as an Erythrocyte Sedimentation Rate parameter) that is too high, resulting in a distorted detection result. Therefore, at this time, the first drive unit 108 and the second drive unit 109 with a larger capacity can be controlled to aspirate and / or spit liquid to deaggregate the blood sample in order to restore the blood parameter value to normal.

[0134] In the second case, when the detected blood parameter value is greater than the preset blood parameter value, it is also possible that the blood parameter value itself is indeed abnormal and the test result is correct. At this time, the aggregation parameters of the blood sample can be corrected accordingly based on the blood parameter value.

[0135] In the third case, when the detected blood parameter value is greater than the preset blood parameter value, it can be determined that the test result is suspected to be distorted, and the unit with a larger capacity among the first drive unit 108 and the second drive unit 109 is controlled to aspirate and / or spit liquid to deaggregate the blood sample, so as to restore the blood parameter value to normal, and then the blood parameter value of the blood sample is retested to obtain a rechecked value of the blood parameter value, which is recorded as the rechecked parameter value.

[0136] When the review parameter value is normal, the review parameter value is used as the latest blood parameter value of the blood sample. When the review parameter value is still abnormal, that is, the review parameter value is still greater than the preset blood parameter value, it can be determined that the test result is distorted. Based on the blood parameter value and / or the review parameter value, the polymerization parameter of the sample liquid is corrected.

[0137] Based on the above method, it is possible to avoid outputting distorted detection results as much as possible, thereby improving the accuracy of the detection results and the reliability of the optical index analyzer.

[0138] In the description of the present application, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradicting each other.

[0139] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0140] Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, segment or portion of code that includes one or more executable instructions for implementing the steps of a specific logical function or process, and the scope of the preferred embodiments of the present application includes alternative implementations in which functions may not be performed in the order shown or discussed, including performing functions in a substantially simultaneous manner or in the reverse order depending on the functions involved, which should be understood by technicians in the technical field to which the embodiments of the present application belong.

[0141] The logic and / or steps represented in the flowchart or otherwise described herein, for example, can be considered as an ordered list of executable instructions for implementing the logical functions, and can be embodied in any computer-readable medium for use by an instruction execution system, device or apparatus (which can be a personal computer, server, network device or other system that can fetch instructions from the instruction execution system, device or apparatus and execute the instructions), or in combination with these instruction execution systems, devices or apparatuses. For the purpose of this specification, "computer-readable medium" can be any device that can contain, store, communicate, propagate or transmit a program for use by an instruction execution system, device or apparatus or in combination with these instruction execution systems, devices or apparatuses. More specific examples of computer-readable media (a non-exhaustive list) include the following: an electrical connection with one or more wires (electronic device), a portable computer disk box (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable and programmable read-only memory (EPROM or flash memory), a fiber optic device, and a portable compact disk read-only memory (CDROM). In addition, the computer-readable medium may even be paper or other suitable medium on which the program is printed, since the program may be obtained electronically, for example, by optically scanning the paper or other medium and then editing, interpreting or processing in other suitable ways if necessary, and then stored in a computer memory.

[0142] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. An optical index analyzer, characterized in that: include: At least two test liquid preparation units; A hard solution unit, the hard solution unit is used to destroy the negative pressure maintaining mechanism of the mobile storage unit, collect the sample liquid in the mobile storage unit, transfer the collected sample liquid, and inject the collected sample liquid into at least two of the test liquid preparation units respectively; a first soft solution unit, the first soft solution unit being connected to the hard solution unit; A first three-way unit, wherein a first end of the first three-way unit is connected to the first soft solution unit; a second soft solution unit, the second soft solution unit being connected to the second end of the first three-way unit; a third soft solution unit, the third soft solution unit being connected to the third end of the first three-way unit; The parameters of the second soft solution unit are different from the parameters of the third soft solution unit, and the parameters include at least one of the inner diameter of the tube, the length of the tube and the material of the tube; and / or, the pH value of the liquid contained in the second soft solution unit is lower than the pH value of the liquid contained in the third soft solution unit, and the pH value of the liquid contained in the second soft solution unit and the pH value of the liquid contained in the third soft solution unit are both not less than 7, Alternatively, the pH value of the liquid contained in the second soft solution unit is greater than the pH value of the liquid contained in the third soft solution unit, and the pH value of the liquid contained in the second soft solution unit and the pH value of the liquid contained in the third soft solution unit are both not greater than 7; And / or, the HLB value of the liquid contained in the second soft solution unit is smaller than the HLB value of the liquid contained in the third soft solution unit; And / or, the CMC value of the liquid contained in the second soft solution unit is smaller than the CMC value of the liquid contained in the third soft solution unit; Wherein, the first three-way unit is one of a three-way valve, a three-way connector and two two-way valves; The optical index analyzer also includes: a first fixed liquid storage unit, wherein the second soft solution unit is connected to the first fixed liquid storage unit; a first driving unit, the first driving unit being connected to the second soft solution unit; a second driving unit, the second driving unit being connected to the third soft solution unit; A second three-way unit, wherein the second three-way unit is one of a three-way connector, a three-way valve, a four-way connector, a four-way valve, two three-way connectors connected to each other, and two three-way valves connected to each other; The second three-way unit is respectively connected to the first drive unit, the third soft solution unit and the second drive unit, and the first fixed liquid storage unit is connected to the second drive unit, or the second three-way unit is respectively connected to the first drive unit, the first fixed liquid storage unit, the third soft solution unit and the second drive unit.

2. The optical index analyzer according to claim 1, characterized in that: The optical index analyzer also includes: a first fixed liquid storage unit; a second fixed liquid storage unit; The second soft solution unit is connected to the first fixed liquid storage unit, and the second fixed liquid storage unit is not connected to the second soft solution unit, and the second fixed liquid storage unit is not connected to the third soft solution unit; Wherein, the parameters of the first fixed liquid storage unit are different from the parameters of the second fixed liquid storage unit, and the parameters include at least one of volume and material; and / or, the pH value of the liquid stored in the first fixed liquid storage unit is lower than the pH value of the liquid stored in the second fixed liquid storage unit, and the pH value of the liquid stored in the first fixed liquid storage unit and the pH value of the liquid stored in the second fixed liquid storage unit are both not less than 7, Alternatively, the pH value of the liquid stored in the first fixed liquid storage unit is greater than the pH value of the liquid stored in the second fixed liquid storage unit, and the pH value of the liquid stored in the first fixed liquid storage unit and the pH value of the liquid stored in the second fixed liquid storage unit are both not greater than 7; And / or, the HLB value of the liquid stored in the first fixed liquid storage unit is smaller than the HLB value of the liquid stored in the second fixed liquid storage unit; And / or, the CMC value of the liquid stored in the first fixed liquid storage unit is smaller than the CMC value of the liquid stored in the second fixed liquid storage unit.

3. The optical index analyzer according to claim 2, characterized in that: At least two of the test liquid preparation units are fixed on the same target horizontal line, the target horizontal line extends along the target horizontal direction, the hard solution unit is used to move in the target vertical direction and the target horizontal direction, and the target vertical direction and the target horizontal direction are perpendicular to each other; All units in the optical index analyzer are located in the same accommodation space, the second fixed liquid storage unit is not connected to any of the test liquid preparation units, and the second fixed liquid storage unit and at least two of the test liquid preparation units are located on the same target horizontal line, the second fixed liquid storage unit is located on one side of all the test liquid preparation units, or all units in the optical index analyzer except the second fixed liquid storage unit are located in a accommodation space, and the second fixed liquid storage unit is located outside the accommodation space; And / or, a recoverable opening cover is provided at the opening of the second fixed liquid storage unit, and the opening on the hard solution unit for collecting the sample liquid is located on a side of the hard solution unit.

4. The optical index analyzer according to claim 2, characterized in that: The hard solution unit is used to collect the liquid in the second fixed liquid storage unit, transfer the collected liquid in the second fixed liquid storage unit, and inject the collected liquid in the second fixed liquid storage unit into at least two of the test liquid preparation units respectively; Wherein, in the process of respectively injecting the collected liquid in the second fixed liquid storage unit into at least two of the test liquid preparation units, the collected liquid in the second fixed liquid storage unit is firstly injected into the test liquid preparation unit containing the hemolytic agent among all the test liquid preparation units; And / or, after collecting the liquid in the second fixed liquid storage unit, the collected liquid in the second fixed liquid storage unit is made to pass through the first three-way unit back and forth multiple times.

5. The optical index analyzer according to any one of claims 1 to 4, characterized in that: The optical index analyzer also includes: a first driving unit, the first driving unit being connected to the second soft solution unit; a second driving unit, the second driving unit being connected to the third soft solution unit; The parameters of the first driving unit are different from the parameters of the second driving unit.

6. The optical index analyzer according to claim 5, characterized in that: A ratio of the capacity of the second drive unit to that of the first drive unit is greater than or equal to 40 and less than or equal to 120; And / or, a ratio of the capacity of the third soft solution unit to the capacity of the second driving unit is greater than or equal to 0.3 and less than or equal to 2; And / or, the optical index analyzer further comprises a second fixed liquid storage unit, and the second driving unit must be used for the liquid aspiration operation of the second fixed liquid storage unit.

7. The optical index analyzer according to any one of claims 1 to 4, characterized in that: The optical index analyzer also includes: a first fixed liquid storage unit; a second fixed liquid storage unit; The second soft solution unit is connected to the first fixed liquid storage unit, and the second fixed liquid storage unit is not connected to the second soft solution unit, and the second fixed liquid storage unit is not connected to the third soft solution unit; Wherein, the maximum time length that the liquid in the first fixed liquid storage unit stays in the hard solution unit is greater than the maximum time length that the liquid in the second fixed liquid storage unit stays in the hard solution unit; And / or, the driving force to which the liquid in the second fixed liquid storage unit is subjected during the corresponding cleaning operation is greater than or equal to the driving force to which the liquid in the first fixed liquid storage unit is subjected during the corresponding cleaning operation.

8. The optical index analyzer according to any one of claims 1 to 4, characterized in that: When the hard solution unit collects the sample liquid, the length of the pipeline through which the sample liquid passes is not greater than 500 mm and not less than 220 mm, and / or the inner diameter of the pipeline through which the sample liquid passes is not greater than 1.2 mm and not less than 0.8 mm.

9. The optical index analyzer according to any one of claims 1 to 4, characterized in that: The optical index analyzer also includes: Pressure detection unit; a first driving unit, the first driving unit being connected to the second soft solution unit; a second driving unit, the second driving unit being connected to the third soft solution unit; a control unit, wherein the control unit is respectively connected to the pressure detection unit, the first driving unit and the second driving unit; When the hard solution unit collects the sample liquid, the pressure detection unit is used to detect the pressure value in the first soft solution unit or the second soft solution unit or the third soft solution unit; The control unit is used for: When it is detected that the absolute value of the pressure value is greater than the absolute value of the preset pressure value, the first driving unit and the second driving unit with a larger capacity are controlled to suck and / or discharge liquid.

10. The optical index analyzer according to any one of claims 1 to 4, characterized in that: The optical index analyzer also includes: Blood parameter detection unit; a first driving unit, the first driving unit being connected to the second soft solution unit; a second driving unit, the second driving unit being connected to the third soft solution unit; A control unit, wherein the control unit is connected to the blood parameter detection unit, the first driving unit and the second driving unit respectively; When the hard solution unit collects the sample liquid, the blood parameter detection unit is used to detect the blood parameter value in the first soft solution unit; The control unit is used for: When it is detected that the blood parameter value is greater than a preset blood parameter value, controlling the first driving unit and the second driving unit with a larger capacity to aspirate or discharge liquid; or, when it is detected that the blood parameter value is greater than the preset blood parameter value, the polymerization parameter of the sample liquid is corrected based on the blood parameter value; Or, when it is detected that the blood parameter value is greater than the preset blood parameter value, first control the first drive unit and the second drive unit with a larger capacity to aspirate and / or spit out liquid, and then detect the blood parameter value in the first soft solution unit to obtain a review parameter value, and when it is detected that the review parameter value is greater than the preset blood parameter value, the polymerization parameter of the sample liquid is corrected based on the blood parameter value and / or the review parameter value.

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