Method for evaluating oil control efficacy of cosmetics and raw materials

By detecting the inhibitory effect of cosmetics on 5α-reductase, the problems of long human test cycle and poor repetition of in vitro tests in the evaluation of cosmetic oil control efficacy were solved, and an economical and fast evaluation method with reliable results was achieved, reducing costs and improving standardization degree.

CN119193760APending Publication Date: 2024-12-27GUANGDONG YOUZHI TESTING TECH CO LTD
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Patent Information

Application Number
CN202411616988.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-13
Publication Date
2024-12-27

AI Technical Summary

Technical Problem

The existing cosmetic oil control efficacy evaluation methods lack unified standards, the human test cycle is long and the cost is high, the in vitro test is poor and the scientificity is insufficient, and the results are biased due to individual differences in humans.

Method used

By detecting the inhibitory effect of the sample on 5α-reductase, the NADPH absorbance change was measured by a microplate reader, the inhibition rate of 5α-reductase was calculated, and the oil control effect of cosmetics was evaluated in combination with statistical analysis.

Benefits of technology

A cost-effective and reliable evaluation method for cosmetic oil control efficacy is achieved, which avoids the result deviation caused by individual differences in humans, reduces costs, shortens the evaluation cycle, and improves the standardization and repeatability of the evaluation.

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Abstract

The invention discloses a method for evaluating the oil control effect of cosmetics and raw materials, and the test method comprises the following steps: preparing a 5 alpha-reductase working solution by using SD rat liver microsomes, co-incubating a sample to be tested and the 5 alpha-reductase working solution, adding NADPH and testosterone for reaction, determining the change of the NADPH content, detecting the inhibition effect of the sample on the 5 alpha-reductase, and evaluating the oil control effect of the cosmetics and the raw materials according to the inhibition effect of the sample on the 5 alpha-reductase. And analyzing and evaluating the oil control effect of the sample through statistical means. The invention discloses a method for evaluating the oil control effect of cosmetics, and aims to provide a test method for evaluating the oil control effect of cosmetics by adopting a 5alpha-reductase inhibition test, the method adopts the 5alpha-reductase inhibition test to replace a human body test, large result deviation caused by human body individual difference is avoided, and compared with a cell test, the test method is simple in process, low in cost, short in time consumption and high in accuracy. The method is economical and fast, the test process is controllable, the test system is standardized, and the judgment standard of the oil control effect is established through multiple practical applications.
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Citation Information

Patent Citations

  • Method for evaluating oil control efficacy of cosmetics and raw materials by using in-vitro cells

    CN118147266A