Raman spectrum combined lens and Raman spectrometer

Abstract

The embodiment of the invention discloses a Raman spectrum combined lens and a Raman spectrometer. The Raman spectrum combined lens comprises a shading structural member, a light receiving lens, an optical filter, a beam splitter prism and a condensing lens, the first end of the shading structural member is provided with a light inlet, the light receiving lens is arranged at the second end of the shading structural member and is sealed, the first optical surface of the light receiving lens faces the light inlet, and the side wall between the first end and the second end of the shading structural member is made of a light-proof material; the second optical surface of the light receiving lens faces the first optical surface of the beam splitter prism, the second optical surface of the beam splitter prism faces the first optical surface of the condensing lens, and the second optical surface of the condensing lens serves as a light output surface of the Raman spectrum combined lens; the optical filter is used for filtering light rays emitted to the light inlet or light rays emitted from the light inlet. The influence of the outside on a detection light path is isolated through the shading structural part, the interference of ambient light on detection is eliminated, the signal-to-noise ratio of Raman spectrum is increased, and then the sensitivity and accuracy of blood glucose testing are improved.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of optical detection technology, and in particular to a Raman spectrum combination lens and a Raman spectrometer. Background Art

[0002] Diabetes can cause various acute and long-term complications in patients with blood sugar levels exceeding 600 mg / dl, such as blindness, kidney disease, neurological and circulatory system diseases, amputation, stroke and cardiovascular disease. Regular monitoring of blood sugar is an essential step for doctors and patients to manage diabetes. Blood sugar testing is divided into three methods: invasive, minimally invasive and non-invasive. Invasive methods usually require puncturing the skin (usually fingers) to draw blood samples, causing pain and discomfort to patients, and accompanied by the risk of potential infection or tissue damage. Minimally invasive methods reduce the pain caused by blood sampling, but there are problems such as allergies or discomfort to implants, delayed measurement values, and high costs. Non-invasive methods can be achieved through various spectral analyses and body fluid tests. Among them, Raman spectroscopy has the characteristics of molecular fingerprints and has been widely used in the qualitative and quantitative analysis of molecular components. Compared with ordinary component detection, non-invasive blood sugar detection still has great technical challenges. For example, non-invasive blood sugar detection based on Raman spectroscopy analysis has problems such as weak signals and many interferences. Summary of the invention

[0003] The embodiment of the present invention provides a Raman spectrum combination lens and a Raman spectrometer to solve the technical problems of weak signal and much interference in the existing non-invasive blood glucose detection based on Raman spectrum analysis.

[0004] In a first aspect, an embodiment of the present invention provides a Raman spectroscopy combination lens, including a light shielding structure, a light collecting lens, a filter, a beam splitter prism and a focusing lens;

[0005] The first end of the light-shielding structure is provided with a light inlet, the light-collecting lens is provided at the second end of the light-shielding structure and seals the second end of the light-shielding structure, the first optical surface of the light-collecting lens faces the light inlet, and the side wall between the first end and the second end of the light-shielding structure is made of an opaque material;

[0006] The second optical surface of the light-collecting lens faces the first optical surface of the beam splitter prism, the second optical surface of the beam splitter prism faces the first optical surface of the condenser lens, and the second optical surface of the condenser lens serves as the light output surface of the Raman spectrum combination lens;

[0007] The filter is used to filter the light emitted toward the light inlet or the light incident from the light inlet.

[0008] The light-shielding structure is cylindrical, or the light-shielding structure is truncated cone-shaped and the radius of the first end of the light-shielding structure is smaller than the radius of the second end of the light-shielding structure.

[0009] Wherein, the shading structure is coaxially arranged with the light collecting lens.

[0010] Among them, a focus of the light-collecting lens is inside the light inlet.

[0011] Wherein, the filter is arranged between the light collecting lens and the beam splitting prism.

[0012] Wherein, the filter is arranged on the inner side wall of the light-shielding structure.

[0013] In a second aspect, an embodiment of the present invention provides a Raman spectrometer, comprising any Raman spectrum combination lens according to the first aspect, wherein the Raman spectrum combination lens is disposed in a light-proof lens barrel.

[0014] The size of the light inlet may be equal to the size of the object to be measured.

[0015] It also includes a light source and a reflector, which are arranged in the lens barrel, and the light emitted by the light source is reflected from the light inlet through the reflector.

[0016] It also includes a light source, which is arranged on the inner wall of the shading structure, and the light emitting direction of the light source is toward the light inlet.

[0017] The Raman spectrum combination lens and Raman spectrometer provided by the embodiment of the present invention include a shading structure, a light collecting lens, a filter, a beam splitter prism and a focusing lens; the first end of the shading structure is provided with a light inlet, the light collecting lens is provided at the second end of the shading structure, and the second end of the shading structure is sealed, the first optical surface of the light collecting lens faces the light inlet, and the side wall between the first end and the second end of the shading structure is made of an opaque material; the second optical surface of the light collecting lens faces the first optical surface of the beam splitter prism, the second optical surface of the beam splitter prism faces the first optical surface of the focusing lens, and the second optical surface of the focusing lens serves as the light output surface of the Raman spectrum combination lens; the filter is used to filter the light emitted toward the light inlet or the light incident from the light inlet. The shading structure isolates the influence of the outside world on the detection optical path, eliminates the interference of ambient light on the detection, improves the signal-to-noise ratio of the Raman spectrum, and thus improves the sensitivity and accuracy of blood glucose testing. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Other features, objects and advantages of the present application will become more apparent by reading the detailed description of non-limiting embodiments made with reference to the following drawings:

[0019] Figure 1 It is a schematic diagram of the component arrangement of a Raman spectroscopy combination lens provided in an embodiment of the present application;

[0020] Figure 2 It is a schematic diagram of the component setting of the existing Raman spectroscopy combination lens;

[0021] Figure 3 is a structural schematic diagram of a first type of light-shielding structural member provided in an embodiment of the present application;

[0022] Figure 4 It is a structural schematic diagram of the second shading structural component provided in the embodiment of the present application.

[0023] Among them: 101-the object to be measured; 102-the light-collecting lens; 103-the filter; 104-the beam splitter; 105-the focusing lens; 106-the photoelectric target surface; 201-the object to be measured; 202-the light-collecting lens; 203-the light-shielding structure; 203a-the light inlet; 204-the beam splitter; 205-the focusing lens; 206-the photoelectric target surface. DETAILED DESCRIPTION

[0024] The present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It will be appreciated that the specific embodiments described herein are intended to explain the present application, rather than to limit the present application. It should also be noted that, for ease of description, only portions of the present application, rather than all structures, are shown in the accompanying drawings. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work are within the scope of protection of the present application.

[0025] The terms "first", "second", "third" and "fourth" etc. in the specification and claims of the present application and the drawings are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0026] Reference to "embodiments" herein means that a particular feature, result, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments to form optional implementation methods.

[0027] The following describes the various embodiments of the present invention in detail.

[0028] The components of the existing Raman spectroscopy combination lens are set as follows: Figure 2 As shown, the optical path of the existing Raman spectrum combination lens for Raman spectrum detection is also comprehensively shown. Please refer to Figure 2, the Raman spectrum combination lens performs Raman spectrum detection on the object 101 to be measured. The light-collecting lens 102 is a convex lens, which is mainly used to focus the Raman scattered photons of the test point on the object 101 to be measured; the filter 103 is an optical device that can filter other types of light generated by the test point, such as Rayleigh scattered light; the spectroscopic prism 104 is an optical device used to diffract the Raman spectrum; the focusing lens 105 is a convex lens used to focus the Raman spectrum after diffraction and splitting. The focusing lens 105 focuses the Raman spectrum incident on the Raman spectrum combination lens onto the photoelectric target surface 106. The photoelectric target surface 106 generates an electrical signal based on photoelectric conversion to obtain detection data for analysis to obtain the detection result. In the above processing, other types of photons entering the Raman spectrum combination lens through the light-collecting lens 102 may cause the overall Raman spectrum to account for a low proportion, a weak signal, and a low signal-to-noise ratio, thereby causing the final detection result to be inaccurate.

[0029] Figure 1 Schematic diagram of the component arrangement of the Raman spectrum combination lens provided in an embodiment of the present invention. The Raman spectrum combination lens isolates the influence of the outside world on the detection optical path through the shading structure, eliminates the interference of ambient light on the detection, improves the signal-to-noise ratio of the Raman spectrum, and further improves the sensitivity and accuracy of the detection. Please refer to Figure 1 The Raman spectrum combination lens in the embodiment of the present invention comprises: a light-shielding structure 203, a light-collecting lens 202, a filter, a beam splitter prism 204 and a condensing lens 205; a light inlet 203a is arranged at the first end of the light-shielding structure 203, the light-collecting lens 202 is arranged at the second end of the light-shielding structure 203, and seals the second end of the light-shielding structure 230, the first optical surface of the light-collecting lens 202 faces the light inlet 203a, and the side wall between the first end and the second end of the light-shielding structure 203 is made of an opaque material; the second optical surface of the light-collecting lens 202 faces the first optical surface of the beam splitter prism 204, the second optical surface of the beam splitter prism 204 faces the first optical surface of the condensing lens 205, and the second optical surface of the condensing lens 205 serves as a light output surface of the Raman spectrum combination lens; the filter is used to filter the light emitted toward the light inlet 203a or the light incident from the light inlet 203a.

[0030] Based on the above component settings, when performing Raman spectrum detection, the shading structure 203 can directly isolate ambient light from the source to prevent ambient light from entering the Raman spectrum combination lens and interfering with the final detection result. When the light emitted by the light source hits the object 201 to be detected through the light inlet 203a, the various spectra generated on the object 201 to be detected enter the Raman spectrum combination lens through the light inlet 203a, and the detection is completed based on the photoelectric conversion process that is the same as the detection principle of the prior art. In this process, the detection in the light isolation state can ensure that all detection data comes from the object 201 to be detected, and no photon type other than the Raman spectrum interferes with the detection result, thereby improving the signal-to-noise ratio and improving the sensitivity and accuracy of the detection result.

[0031] When the present solution is implemented, the shading structure 203 is as follows: Figure 3 The cylindrical shape shown ( Figure 3 The axial cross-sectional shape is shown), or the shading structure 203 is as follows Figure 4 The truncated cone shown ( Figure 3 The shading structure 203 is a cylindrical or truncated cone-shaped shading structure 203, and the circular light-collecting lens 202 can be adapted to simplify the structure. Of course, the overall shape of the shading structure 203 can also be a rectangular parallelepiped, and the light-collecting lens 202 with a circular cross-section is embedded in a bottom surface of the rectangular parallelepiped. The shading structure 203 is coaxially arranged with the light-collecting lens 202 to achieve the best possible light transmission effect. In order to obtain the best possible detection effect under the same light intensity, a focus of the light-collecting lens 202 (i.e., the focus on the first optical surface of the light-collecting lens 202) is within the light inlet 203a, which is equivalent to the detection object being located exactly at the focus of the light-collecting lens 202. The light source entering the light-collecting lens 202 from the focus can obtain the best transmission effect and detection result. Of course, in actual implementation, the focus may also deviate from the light inlet 203a within a certain range, as long as the number of photons that finally enter the photoelectric target surface 206 reaches the detection accuracy standard.

[0032] The filter in the embodiment of the present application can be arranged between the light-collecting lens 202 and the beam splitter prism 204, or can be arranged on the inner side wall of the light-shielding structure 203. The filter is arranged between the light-collecting lens 202 and the beam splitter prism 204, which is equivalent to filtering the light that enters the Raman spectrum combination lens and affects the final detection result, thereby ensuring the accuracy of the detection result. The filter is arranged on the inner side wall of the light-shielding structure 203, which is equivalent to filtering both the light emitted by the light source and the light entering the Raman spectrum combination lens, further improving the accuracy of the detection result.

[0033] In general, the Raman spectrum combination lens includes a shading structure, a light-collecting lens, a filter, a beam splitter prism and a focusing lens; the first end of the shading structure is provided with a light inlet, the light-collecting lens is provided at the second end of the shading structure, and the second end of the shading structure is sealed, the first optical surface of the light-collecting lens faces the light inlet, and the side wall between the first end and the second end of the shading structure is made of an opaque material; the second optical surface of the light-collecting lens faces the first optical surface of the beam splitter prism, the second optical surface of the beam splitter prism faces the first optical surface of the focusing lens, and the second optical surface of the focusing lens serves as the light output surface of the Raman spectrum combination lens; the filter is used to filter the light emitted toward the light inlet or the light incident from the light inlet. The shading structure isolates the influence of the outside world on the detection optical path, eliminates the interference of ambient light on the detection, improves the signal-to-noise ratio of the Raman spectrum, and thus improves the sensitivity and accuracy of blood glucose testing.

[0034] The embodiment of the present application further provides a Raman spectrometer, including the Raman spectrum combination lens in any of the above embodiments, and the Raman spectrum combination lens is arranged in a light-proof lens barrel. Through the light-proof Raman spectrum combination lens, during detection, for example, when detecting body surface tissue, the body surface tissue can be tightly sealed to the light inlet through close contact, thereby preventing external ambient light from entering the Raman spectrum combination lens and affecting the final detection result. In order to ensure the blocking effect of the light inlet, the size of the light inlet may be equal to the size of the object to be measured in different detection scenarios, so that the object to be measured can accurately cover the light inlet during detection.

[0035] For the light source in the Raman spectrometer, there can be more specific settings. For example, a matching light source is provided with a reflector, the light source and the reflector are provided in the lens barrel, and the light emitted by the light source is reflected from the light inlet through the reflector, that is, the light source realizes lighting the object to be measured through optical path conversion. Another example is a matching light source, the light source is provided on the inner wall of the light-shielding structure, and the light-emitting direction of the light source is toward the light inlet, that is, the light source realizes direct lighting to the object to be measured. Correspondingly, the light source is provided on the inner wall of the light-shielding structure, for example, the light-emitting direction of the light source is 45° with the inner wall of the light-shielding structure, so as to avoid the light source blocking the optical path of the incident light during detection.

[0036] The Raman spectrometer implemented based on the Raman spectrum combination lens described above has the same beneficial effects.

[0037] It should be noted that in the embodiments of the present application, some common technologies in the art are not elaborated in detail. Corresponding traditional technologies, such as laser, can be used when implementing this solution.

[0038] It should also be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device including the elements.

[0039] Note that the above are only preferred embodiments of the present invention and the technical principles used. Those skilled in the art will understand that the present invention is not limited to the specific embodiments herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments, and may include more other equivalent embodiments without departing from the concept of the present invention, and the scope of the present invention is determined by the scope of the appended claims.

Claims

1. A Raman spectrum combination lens, characterized in that: It includes a light-shielding structure, a light-collecting lens, a filter, a beam splitter prism and a focusing lens; The first end of the light-shielding structure is provided with a light inlet, the light-collecting lens is provided at the second end of the light-shielding structure and seals the second end of the light-shielding structure, the first optical surface of the light-collecting lens faces the light inlet, and the side wall between the first end and the second end of the light-shielding structure is made of an opaque material; The second optical surface of the light-collecting lens faces the first optical surface of the beam splitter prism, the second optical surface of the beam splitter prism faces the first optical surface of the condenser lens, and the second optical surface of the condenser lens serves as the light output surface of the Raman spectrum combination lens; The filter is used to filter the light emitted toward the light inlet or the light incident from the light inlet.

2. The Raman spectrum combination lens according to claim 1, characterized in that: The light-shielding structure is cylindrical, or the light-shielding structure is truncated cone-shaped and the radius of the first end of the light-shielding structure is smaller than the radius of the second end of the light-shielding structure.

3. The Raman spectrum combination lens according to claim 2, characterized in that: The light-shielding structure is coaxially arranged with the light-collecting lens.

4. The Raman spectrum combination lens according to claim 2 or 3, characterized in that: A focal point of the light-collecting lens is within the light inlet.

5. The Raman spectrum combination lens according to claim 2 or 3, characterized in that: The filter is arranged between the light collecting lens and the beam splitting prism.

6. The Raman spectrum combination lens according to claim 2 or 3, characterized in that: The filter is arranged on the inner side wall of the light shielding structure.

7. A Raman spectrometer, characterized in that: The Raman spectrum combination lens comprises the Raman spectrum combination lens according to any one of claims 1 to 6, wherein the Raman spectrum combination lens is arranged in a light-proof lens barrel.

8. The Raman spectrometer according to claim 7, characterized in that: The size of the light inlet may be equal to the size of the object to be measured.

9. The Raman spectrometer according to claim 7 or 8, characterized in that: It also includes a light source and a reflector, which are arranged in the lens barrel, and the light emitted by the light source is reflected from the light inlet through the reflector.

10. The Raman spectrometer according to claim 7 or 8, characterized in that: It also includes a light source, which is arranged on the inner side wall of the light-shielding structure, and the light emitting direction of the light source is toward the light inlet.

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