A combined cell parameter analyzer

Abstract

The present application discloses a cell parameter joint analyzer. In the cell parameter joint analyzer provided by the present application, a two-dimensional motion component is slidably arranged in the vertical direction relative to a slide assembly; the pipeline assembly includes a first motion pipeline, a second fixed pipeline and a third motion pipeline connected in sequence, one end of the first motion pipeline is connected to the two-dimensional motion component, and one end of the third motion pipeline is connected to the interference reduction component; the cell vertical parameter measurement component is sleeved on the outer side of the second fixed pipeline. Among them, the two-dimensional motion component, the second fixed pipeline and the cell vertical parameter measurement component are all arranged on the slide assembly, that is, the three are relatively static, which can reduce the relative movement between the three, and thus reduce the disturbance to the sample in the pipeline; and by setting the length and inner diameter of each pipeline in the pipeline assembly, the disturbance of the sample transported in the pipeline assembly is further reduced, and the detection efficiency and accuracy of the cell vertical parameter measurement component to the sample are improved.

Description

Technical Field

[0001] The present application relates to the technical field of cell detection, and in particular to a cell parameter combined analyzer. Background Art

[0002] The universal laws of fluid mechanics break down at the mesoscopic scale: a scale larger than the microscopic scale of a single molecule, but smaller than the macroscopic scale, where the universal laws apply. A typical example of a mesoscopic fluid is the blood flowing through a blood vessel; the blood cells that make up this fluid are so large that they cannot be simply viewed as a collection of microscopic molecules, but rather as mesoscopic entities with complex behaviors, and establishing accurate mathematical models for such materials remains an ongoing challenge. As such, this poses a great challenge to accurate measurements in IVD (In Vitro Diagnostic) devices. Summary of the invention

[0003] In order to solve the above technical problems, the present application provides a cell parameter joint analyzer. In some embodiments, the cell parameter joint analyzer provided by the present application includes a slide rail assembly, a slide seat assembly, a two-dimensional motion assembly, a disturbance reduction assembly, a pipeline assembly and a cell vertical parameter measurement assembly;

[0004] The slide rail assembly is arranged in the cell parameter combined analyzer along the horizontal direction;

[0005] The slide seat assembly is slidably disposed on the slide rail assembly to move horizontally along the slide rail assembly;

[0006] The two-dimensional motion component is a double-end open cylinder, the two-dimensional motion component is slidably arranged in the vertical direction relative to the slide assembly, and the lower end opening of the two-dimensional motion component is used to draw samples from the sample holding tube containing the samples into the pipeline assembly;

[0007] The interference reduction component is arranged in the cell parameter joint analyzer and connected to the two-dimensional motion component through the pipeline component;

[0008] The pipeline assembly comprises a first motion pipeline, a second fixed pipeline and a third motion pipeline which are connected in sequence, the upper end opening of the two-dimensional motion assembly is connected to the first end of the first motion pipeline, the second end of the first motion pipeline is connected to the first end of the second fixed pipeline, the second end of the second fixed pipeline is connected to the first end of the third motion pipeline, and the second end of the third motion pipeline is connected to the interference reduction assembly;

[0009] The cell vertical parameter measurement component is sleeved on the outside of the second fixed pipeline, and is used to measure the cell vertical parameters of the sample in the second fixed pipeline;

[0010] Wherein, the two-dimensional motion component, the second fixed pipeline and the cell vertical parameter measurement component are arranged on the slide assembly;

[0011] The length of the first motion pipeline is less than or equal to 400 mm, the inner diameter of the first motion pipeline is less than or equal to 2 mm, and the vertical motion range of the two-dimensional motion component is less than or equal to 200 mm, and the length of the first motion pipeline is greater than the vertical motion range of the two-dimensional motion component;

[0012] And / or, the length of the second fixed pipeline is greater than or equal to 40 mm, and the inner diameter of the second fixed pipeline is greater than or equal to 0.4 mm;

[0013] And / or, the length of the third motion pipeline is greater than or equal to 500 mm, and the inner diameter of the third motion pipeline is less than or equal to 2 mm;

[0014] And / or, a ratio of a length of the third motion pipeline to a length of the first motion pipeline is greater than 3.

[0015] Among them, in some embodiments, the cell parameter joint analyzer provided by the present application includes a slide rail assembly, a slide seat assembly, a two-dimensional motion assembly, a disturbance reduction assembly, a pipeline assembly, and a cell vertical parameter measurement assembly;

[0016] The slide rail assembly is arranged in the cell parameter combined analyzer along the horizontal direction;

[0017] The slide seat assembly is slidably disposed on the slide rail assembly to move horizontally along the slide rail assembly;

[0018] The two-dimensional motion component is a double-end open cylinder, the two-dimensional motion component is slidably arranged in the vertical direction relative to the slide assembly, and the lower end opening of the two-dimensional motion component is used to draw samples from the sample holding tube containing the samples into the pipeline assembly;

[0019] The interference reduction component is arranged in the cell parameter joint analyzer and connected to the two-dimensional motion component through the pipeline component;

[0020] The pipeline assembly comprises a first motion pipeline, a second fixed pipeline and a third motion pipeline which are connected in sequence, the upper end opening of the two-dimensional motion assembly is connected to the first end of the first motion pipeline, the second end of the first motion pipeline is connected to the first end of the second fixed pipeline, the second end of the second fixed pipeline is connected to the first end of the third motion pipeline, and the second end of the third motion pipeline is connected to the interference reduction assembly;

[0021] The cell vertical parameter measurement component is sleeved on the outside of the second fixed pipeline, and is used to measure the cell vertical parameters of the sample in the second fixed pipeline;

[0022] Wherein, the two-dimensional motion component, the second fixed pipeline and the cell vertical parameter measurement component are arranged on the slide assembly;

[0023] The radial cross-sectional area of ​​the upper end of the double-end open cylinder is larger than the radial cross-sectional area of ​​the lower end of the double-end open cylinder; the upper end of the double-end open cylinder is connected to the first end of the first motion pipeline, and the lower end of the double-end open cylinder is an end away from the first motion pipeline;

[0024] And / or, the opening at the lower end of the double-ended open cylinder is arranged on the side wall of the double-ended open cylinder;

[0025] And / or, a plurality of axially symmetrical grooves are provided on the outer wall of the double-ended open cylinder, the grooves are in the shape of long strips, and the grooves are extended along the extension direction of the double-ended open cylinder;

[0026] and / or, the minimum distance between the double-ended open cylinder and the second fixed pipeline is less than 50 mm;

[0027] And / or, the angle between the direction in which the liquid flows into the inlet end of the interference reduction component and the direction in which the liquid flows out of the outlet end of the interference reduction component is greater than or equal to 180°.

[0028] Beneficial effects of the present application: Different from the prior art, the cell parameter joint analyzer provided by the present application includes a slide rail assembly, a slide seat assembly, a two-dimensional motion assembly, a disturbance reduction assembly, a pipeline assembly and a cell vertical parameter measurement assembly. The slide rail assembly is arranged in the cell parameter joint analyzer in the horizontal direction, and the slide seat assembly is slidably arranged on the slide rail assembly to move along the horizontal direction of the slide rail assembly. The two-dimensional motion assembly is a double-ended open cylinder, which is slidably arranged in the vertical direction relative to the slide seat assembly, and is used to draw samples from the sample holding tube containing the sample into the pipeline assembly; the disturbance reduction assembly is arranged in the cell parameter joint analyzer, and the two-dimensional motion assembly is connected through the pipeline assembly; the pipeline assembly includes a first motion pipeline, a second fixed pipeline and a third motion pipeline connected in sequence, one end of the first motion pipeline is connected to the two-dimensional motion assembly, and one end of the third motion pipeline is connected to the disturbance reduction assembly; the cell vertical parameter measurement assembly is sleeved on the outside of the second fixed pipeline, and is used to measure the cell vertical parameters of the sample in the second fixed pipeline. Among them, the two-dimensional motion component, the second fixed pipeline and the cell vertical parameter measurement component are all arranged on the slide assembly, that is, the three are relatively still, which can reduce the relative movement between the three, and thus reduce the disturbance to the sample in the pipeline; and by setting the length and inner diameter of each pipeline in the pipeline assembly, the disturbance of the sample transported in the pipeline assembly is further reduced, thereby improving the detection efficiency and accuracy of the cell vertical parameter measurement component for the sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. Among them:

[0030] Figure 1 It is a structural schematic diagram of an embodiment of a cell parameter combined analyzer A of the present application;

[0031] Figure 2 yes Figure 1 A schematic diagram of the front view structure of the combined cell parameter analyzer A;

[0032] Figure 3 yes Figure 2 Schematic diagram of the structure of the local area B;

[0033] Figure 4 It is a structural schematic diagram of an embodiment of a two-dimensional motion component 1 of the present application.

[0034] Figure numbers: cell parameter combined analyzer A; two-dimensional motion component 1; double-ended open cylinder 11; groove 12; pipeline component 2; first motion pipeline 21; second fixed pipeline 22; third motion pipeline 23; interference reduction component 3; slide rail component 4; slide seat component 5; cell vertical parameter measurement component 6; tank chain 7; partition 8; positioning plate 9; positioning groove 91; first direction X; second direction Y. DETAILED DESCRIPTION

[0035] The scheme of the embodiment of the present application is described in detail below in conjunction with the drawings of the specification.

[0036] In the following description, for the purpose of explanation rather than limitation, specific details such as specific system structures, interfaces, and technologies are provided to facilitate a thorough understanding of the present application.

[0037] Reference to "embodiments" in this application means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0038] The term "and / or" in this application is only a description of the association relationship of associated objects, indicating that there may be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this article generally indicates that the objects associated before and after are in an "or" relationship. In addition, "many" in this article means two or more than two. In addition, the term "at least one" in this article means any combination of at least two of any one or more of a plurality of, for example, including at least one of A, B, and C, and can mean including any one or more elements selected from the set consisting of A, B, and C. In addition, the terms "first", "second", and "third" in this application are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features.

[0039] See also Figure 1 and Figure 2 , Figure 1 is a schematic diagram of the structure of a cell parameter combined analyzer A-embodiment of the present application, Figure 2 yes Figure 1The front view structural diagram of the cell parameter joint analyzer A. The cell parameter joint analyzer A provided in the embodiment of the present application comprises a two-dimensional motion component 1, a pipeline component 2, an interference reduction component 3, a slide rail component 4, a slide seat component 5 and a cell vertical parameter measurement component 6. Among them, the detectable items of the cell parameter joint analyzer A include but are not limited to routine blood test items, specific protein (such as CRP, SAA) test items, biochemical test items, immune test items, blood type test, and multiple cell parameters in the erythrocyte sedimentation rate (Erythrocyte Sedimentation Rate) test.

[0040] As shown in the figure, the slide rail assembly 4 is arranged in a horizontal direction (such as Figure 1 The second direction Y) is arranged in the cell parameter joint analyzer A, and the slide seat assembly 5 is slidably arranged on the slide rail assembly 4 to move along the horizontal direction of the slide rail assembly 4.

[0041] The two-dimensional motion component 1 is a double-ended open cylinder, which can be a sampling needle, and is vertically spaced relative to the slide assembly 5 (eg Figure 1 The two-dimensional motion component 1 is arranged to slide in the first direction X), and the lower end opening of the two-dimensional motion component 1 is used to draw the sample from the sample holding tube (not shown) into the pipeline component 2.

[0042] The interference reduction component 3 is arranged in the cell parameter combined analyzer A, and is connected to the two-dimensional motion component 1 through the pipeline component 2 to provide a force for the two-dimensional motion component 1 so that the two-dimensional motion component 1 can absorb the sample in the sample holding tube.

[0043] Please combine Figure 3 , Figure 3 yes Figure 2 Schematic diagram of the structure of the local area B. The pipeline assembly 2 includes a first motion pipeline 21, a second fixed pipeline 22 and a third motion pipeline 23 which are connected in sequence, the upper end opening of the two-dimensional motion assembly 1 is connected to one end of the first motion pipeline 21, the second end of the first motion pipeline 21 is connected to the first end of the second fixed pipeline 22, the second end of the second fixed pipeline 22 is connected to the first end of the third motion pipeline 23, and the second end of the third motion pipeline 23 is connected to the interference reduction assembly 3.

[0044] When the two-dimensional motion component 1 absorbs the sample through the lower opening, the sample can enter the first motion pipeline 21 , the second fixed pipeline 22 and the third motion pipeline 23 in sequence through the upper opening of the two-dimensional motion component 1 .

[0045] The cell vertical parameter measurement component 6 is sleeved on the outside of the second fixed pipeline 22, and is used to measure the cell vertical parameters of the sample in the second fixed pipeline 22. The second fixed pipeline 22 can be a pipeline section on the pipeline component 2 on which the cell vertical parameter measurement component 6 is sleeved.

[0046] Among them, the cell vertical parameters are various cell parameters that can generally be measured using light signals that are relatively vertical or approximately vertical to the object being measured, such as but not limited to CBC (complete blood count), HGB (Hemoglobin), CRP (C-reactive protein), SAA (serum amyloid A), erythrocyte sedimentation rate (Erythrocyte Sedimentation Rate), etc.

[0047] In one embodiment, the two-dimensional motion component 1, the second fixed pipeline 22 and the cell vertical parameter measurement component 6 can all be arranged on the slide assembly 5, the second fixed pipeline 22 can be fixed on the slide assembly 5 in the vertical direction, the slide assembly 5 can drive the second fixed pipeline 22 to move in the horizontal direction on the slide rail assembly 4, the second fixed pipeline 22 remains stationary in the vertical direction, and also remains stationary in the horizontal direction during measurement, which can reduce the disturbance of the sample in the pipeline when the pipeline moves. The cell vertical parameter measurement component 6 can be fixed on the slide assembly 5 and remain relatively stationary with the second fixed pipeline 22, so that there is no need to control the positioning of the measurement position, avoiding the problem of inaccurate measurement results and measurement failure due to differences in the measurement position, and improving the efficiency and accuracy of the cell vertical parameter measurement component 6 in measuring the cell vertical parameters of the sample.

[0048] Since the two-dimensional motion component 1 is slidably arranged in the vertical direction relative to the slide assembly 5, the slide assembly 5 can drive the two-dimensional motion component 1 to move in the horizontal direction on the slide rail assembly 4, thereby realizing the movement of the two-dimensional motion component 1 in the vertical and horizontal directions. The two-dimensional motion component 1 moves in the horizontal direction to realize the precise sampling of samples in multiple sample pools (not shown) in the cell parameter combined analyzer A, and the two-dimensional motion component 1 moves in the vertical direction to pierce the test tube caps of the test tubes downwards and absorb the samples. It moves upward before moving in the horizontal direction to avoid possible collisions, and moves downward during precise sampling to prevent the samples from flowing into the sample pools too high and causing the samples to splash out of the sample pools.

[0049] At the same time, since the two-dimensional motion component 1, the second fixed pipeline 22 and the cell vertical parameter measurement component 6 are all arranged on the slide assembly 5, during the process of the cell vertical parameter measurement component 6 measuring the cell vertical parameters of the sample in the second fixed pipeline 22, the three can maintain a high degree of relative stillness, reducing the disturbance of the sample in the pipeline, so that the sedimentation velocity of the mesoscopic scale sample will not be affected by the disturbance, the sedimentation time will not be prolonged due to the disturbance, and the consistency between different detection equipment will not be affected, thereby improving the measurement efficiency and accuracy of the cell vertical parameter measurement component 6 on the cell vertical parameters of the sample.

[0050] In summary, in the cell parameter combined analyzer A provided by the present application, the two-dimensional motion component 1 can move in the vertical direction and the horizontal direction to absorb the sample in the sample holding tube and divide the sample. The second fixed pipeline 22 is fixed on the slide assembly 5, and the first end of the first motion pipeline 21 will move in the vertical direction with the two-dimensional motion component 1, and the second end of the first motion pipeline 21 will be fixed on the slide assembly 5 with the first end of the second fixed pipeline 22, thereby reducing the movement amplitude of the first motion pipeline 21 with the two-dimensional motion component 1 and reducing the disturbance of the sample in the pipeline.

[0051] The first end of the third moving pipeline 23 is fixed to the slide assembly 5 along with the second end of the second fixed pipeline 22, and the second end of the third moving pipeline 23 is fixed to the interference reduction assembly 3. When the slide assembly 5 moves the second fixed pipeline 22 in the horizontal direction, the middle part of the third moving pipeline 23 will bend or straighten as the slide assembly 5 moves in the horizontal direction, while the two ends of the third moving pipeline 23 are fixed, thereby reducing the disturbance of the sample in the pipeline.

[0052] In one embodiment, the interference reduction component 3 may include a syringe (not shown). During the process of the two-dimensional motion component 1 sucking samples, the syringe provides pressure to the two-dimensional motion component 1 through the pipeline component 2 to improve the efficiency of the two-dimensional motion component 1 in sucking samples. Compared with other driving devices, the syringe is driven smoothly and powerfully, further reducing the disturbance of the sample sucked to the sample in the pipeline system.

[0053] In one embodiment, the optical axis direction of the light beam emitted by the cell vertical parameter measurement component 6 can be horizontal. Since the extension direction of the second fixed pipeline 22 is vertical, that is, the optical axis direction of the light beam emitted by the cell vertical parameter measurement component 6 is perpendicular to the extension direction of the second fixed pipeline 22, and thus the light beam can vertically enter the second fixed pipeline 22. The mesoscopic scale sample only settles in the vertical direction, and the cells will not be subjected to additional resistance on the inner wall of the tube due to the tilt, thereby avoiding the influence of gravity on the measurement accuracy of the sample by the cell vertical parameter measurement component 6.

[0054] In another embodiment, the cell vertical parameter measurement component 6 itself or its shell can be made of shading material to prevent stray light in the environment from entering the second fixed pipeline 22 through the cell vertical parameter measurement component 6 itself or its shell, thereby preventing the measurement accuracy of the cell vertical parameter measurement component 6 from being affected, thereby further improving the measurement accuracy of the cell vertical parameter measurement component 6 for the sample.

[0055] In other embodiments, since the middle portion of the third motion pipeline 23 will bend or straighten as the slide assembly 5 moves in the horizontal direction, the cell parameter joint analyzer A may further include a tank chain 7, which is mounted on the third motion pipeline 23 to limit the bending and straightening amplitudes of the third motion pipeline 23 and prevent the third motion pipeline 23 from moving in the vertical direction, thereby protecting the third motion pipeline 23 and avoiding interference with other components, further reducing disturbances of the sample in the pipeline, and further improving the measurement efficiency and accuracy of the cell vertical parameter measurement component 6 on the sample.

[0056] Optionally, the length of the first motion pipeline 21 is less than or equal to 400 mm, the inner diameter of the first motion pipeline 21 is less than or equal to 2 mm, and the vertical motion range of the two-dimensional motion component 1 is less than or equal to 200 mm, and the length of the first motion pipeline 21 is greater than the vertical motion range of the two-dimensional motion component 1. By setting the length of the first motion pipeline 21 and the vertical motion range of the motion component 1, the overall movement of the first motion pipeline 21 caused by the movement of the first end of the first motion pipeline 21 can be appropriately reduced, thereby reducing the disturbance of the sample in the pipeline caused by the movement of the first motion pipeline 21, reducing the overall movement of the first motion pipeline 21 caused by the movement of the movable end of the first motion pipeline 21 (the first end of the first motion pipeline 21 will move along with the vertical movement of the two-dimensional motion component 1, so it is called the movable end of the first motion pipeline 21), thereby reducing the fluctuation of the sample suction volume caused by the pipeline movement. Limiting the inner diameter of the first motion pipeline 21 is to reduce the influence of the end effect of the two-dimensional motion component 1 on the transportation of the sample to the first motion pipeline 21 when puncturing the test tube cap and sucking the sample, further reduce the axial impact of the sample in the first motion pipeline 21, and further improve the measurement efficiency and accuracy of the cell vertical parameter measurement component 6 on the sample.

[0057] Among them, in a finite length pipeline (i.e., the pipeline has openings at both ends), an end effect will be introduced, that is, the fluid will be subject to additional disturbances and pressure gradients at the inlet and outlet of the pipeline, thereby affecting the flow inside the pipeline. For the convenience of description, a dimensionless number "Reynolds number" is introduced in fluid mechanics to describe the magnitude of the end effect of pipeline parameters.

[0058] The Reynolds number can be expressed as the ratio of inertial force to viscous force in the fluid. When the Reynolds number is small, the influence of viscous force is greater than that of inertial force. The disturbance of the fluid in the pipeline will be attenuated by the viscous force. The fluid flow is stable and laminar. The fluid flows along the pipeline in a direction parallel to the extension of the pipeline. Because the fluid is very stable, it can be regarded as stacked layers without mutual interference between the layers. The velocity distribution of the fluid in the pipe is in the shape of a parabola, and the velocity distribution facing the section is a parabola, and the flow friction loss is small.

[0059] On the contrary, if the Reynolds number is large, the influence of inertial force is greater than that of viscosity, the fluid flow is relatively unstable, and a small change in flow velocity is easy to develop and enhance, forming a disordered and irregular turbulent flow field. At this time, the flow state of the fluid in the tube is that the molecules collide violently with each other, and the flow is not linear but vortex-shaped, the flow friction loss is large, and the fluid disturbance in the pipeline is large.

[0060] Generally, when the Reynolds number of a pipe flow is less than 2100, it is a laminar flow (also known as viscous flow or linear flow), when it is greater than 4000, it is a turbulent flow (also known as turbulent flow or disturbed flow), and 2100 to 4000 is a transitional flow (some scholars believe that 500 to 5000 is a transitional range). Because there is a transitional flow state between laminar flow and turbulent flow, in this range, the flow velocity gradually increases, and the streamline of the fluid begins to swing in a wave-like manner. The frequency and amplitude of the swing increase with the increase in flow velocity, and some small pressure disturbances will produce long-term and long-distance oscillations. Depending on the external conditions, the flow may be laminar or turbulent.

[0061] For flow in a pipe, the Reynolds number Defined as:

[0062] (1)

[0063] Among them, ρ is the density of the fluid in the pipeline. U is the average flow velocity of the fluid in the pipeline, D is the inner diameter of the pipeline, μ is the viscosity of the fluid in the pipeline, ν is the dynamic viscosity of the fluid in the pipeline, Q is the flow rate of the fluid in the pipeline, and A is the cross-sectional area of ​​the pipeline.

[0064] It can be obtained from the above formula that, when other parameters remain unchanged, the size of the Reynolds number is positively correlated with the inner diameter of the pipeline. Therefore, in order to reduce the disturbance of the fluid in the pipeline and reduce the size of the Reynolds number, it is necessary to limit the inner diameter of the pipeline.

[0065] Therefore, this embodiment limits the inner diameter of the first motion pipeline 21 to be less than or equal to 2 mm, so as to reduce the influence of the end effect at the first motion pipeline 21 and further reduce the axial impact of the sample in the first motion pipeline 21.

[0066] In one embodiment, if Figure 1 or Figure 2 As shown, the second end of the first motion pipeline 21 is connected to the upper end of the second fixed pipeline 22. Therefore, in order to ensure the movement efficiency of the two-dimensional motion component 1, the length of the first motion pipeline 21 can also be greater than or equal to the sum of the length of the second fixed pipeline 22 and the maximum moving distance of the two-dimensional motion component 1 in the vertical direction, so that the moving distance of the two-dimensional motion component 1 in the vertical direction will not be limited by the length of the first motion pipeline 21.

[0067] In one embodiment, the first moving pipeline 21, the second fixed pipeline 22 and the third moving pipeline 23 can also be directly composed of a complete pipeline, as long as each section of the complete pipeline meets the various pipe length requirements mentioned above and below. This greatly reduces the manufacturing, installation and maintenance costs of the equipment, avoids the problem of rough pipelines caused by the joints and connecting pipes that need to be interconnected between the sections of the pipeline, reduces local disturbances at the pipeline connections, and further improves the measurement efficiency and accuracy of the cell vertical parameter measurement component 6 for the sample.

[0068] In another embodiment, the second fixed pipeline 22 may also be an independent glass tube segment, while the first moving pipeline 21 and the third moving pipeline 23 are soft plastic tube segments. As long as each section of the pipeline meets the various tube length requirements described above and below, setting the second fixed pipeline 22 as an independent glass tube segment can better limit the movement of the second fixed pipeline 22, avoid the movement of the first moving pipeline 21 and the third moving pipeline 23 involving the second fixed pipeline 22, so that the sample will not be affected by the sedimentation velocity due to disturbance. In addition, the light transmittance of glass is better than that of soft plastic, which can further improve the measurement efficiency and accuracy of the cell vertical parameter measurement component 6 for the sample.

[0069] Optionally, the length of the second fixed pipeline 22 is greater than or equal to 40 mm. As mentioned above, the cell vertical parameter measurement component 6 measures the cell vertical parameters of the sample in the second fixed pipeline 22. Increasing the length of the second fixed pipeline 22 helps to extend the time for the sample to flow through the second fixed pipeline 22, and extend the measurement time of the cell vertical parameter measurement component 6, so that the cell vertical parameter measurement component 6 can fully measure the sample in the second fixed pipeline 22, thereby improving the measurement accuracy of the cell vertical parameter measurement component 6 on the sample.

[0070] Among them, the second fixed pipeline 22 can be defined as a pipeline section that fixes part of the sub-pipelines of the pipeline assembly 2 to the upper and lower fixed structures (such as cable ties) on the slide assembly 5, or a pipeline section on the pipeline assembly 2 wrapped by the cell vertical parameter measurement assembly 6, that is, the length of the second fixed pipeline 22 here is the pipeline length of the second fixed pipeline 22 itself, or the length of the second fixed pipeline 22 can be understood as the distance between the upper and lower fixed structures (such as cable ties) used to fix the second fixed pipeline 22 (the length of the pipeline section fixed by the upper and lower fixed structures), or the pipeline length of the second fixed pipeline 22 wrapped by the cell vertical parameter measurement assembly 6 to prevent stray light from entering, or the pipeline length of the second fixed pipeline 22 wrapped by the cell vertical parameter measurement assembly 6 to heat the wrapped pipeline.

[0071] In addition, the measuring point is in the middle of the second fixed pipeline 22. The longer the second fixed pipeline 22 is, the smaller the influence of stray light entering from the transparent parts at both ends of the second fixed pipeline 22. Increasing the length of the second fixed pipeline 22 allows multiple single-point sensors to be placed in the cell vertical parameter measurement component 6, thereby increasing the robustness of data acquisition and improving the measurement accuracy.

[0072] Optionally, the inner diameter of the second fixed pipeline 22 is greater than or equal to 0.4 mm. Increasing the inner diameter of the second fixed pipeline 22 facilitates the sedimentation of the sample in the second fixed pipeline 22, avoiding excessive tube resistance affecting the actual sedimentation rate (the speed at which the sample settles under certain conditions). In particular, after the pipeline is contaminated by blood samples, the tube resistance may change. When the inner diameter of the tube is greater than a certain diameter, even if contamination occurs, the actual tube resistance generally does not change much, thereby further improving the detection efficiency and accuracy of the sample.

[0073] Optionally, the length of the third motion pipeline 23 is greater than or equal to 500 mm, and the inner diameter of the third motion pipeline 23 is less than or equal to 2 mm. By limiting the length and inner diameter of the third motion pipeline 23, the end effect at the third motion pipeline 23 is reduced, and the disturbance of the sample in the pipeline is reduced.

[0074] Among them, the universal laws of fluid mechanics fail at the mesoscopic scale: the mesoscopic scale is larger than the microscopic scale of a single molecule, but smaller than the macroscopic scale, where the universal laws apply. A typical example of a mesoscopic fluid is the blood flowing through blood vessels; the blood cells that make up this fluid are so large that they cannot be simply regarded as a collection of microscopic molecules, but should be considered as mesoscopic entities with complex behaviors. Establishing accurate mathematical models for such materials remains an ongoing challenge.

[0075] As a mechanical structure with fluid as the main medium, the impact of fluid vibration on the stability of the detection element in the pipeline system is always a problem worth studying in depth. The transitional flow state, coupled with the complex behavior of blood cells in the mesoscopic state, poses a great challenge to accurate measurement in IVD devices.

[0076] The rapid switching of the control element will inevitably form liquid shock in the pipeline assembly, and may propagate and reflect in the pipeline system with a longer pipe length, which may cause continuous flow oscillation. Improper design may even cause failure of the seal of the liquid system, liquid leakage, and even damage to the pump and valve structure, impaired function, and system instability, which in turn leads to insufficient stability of the detection element itself. In order to obtain reasonable parameters for our above-mentioned technical solution, we borrowed the fluid mechanics model constructed in the paper Pomerenka O, Carrillo Segura S, Cao F, Wu J, Ristroph L. Hydrodynamics of finite-lengthpipes at intermediate Reynolds numbers [J]. Journal of Fluid Mechanics, 2023, 959: A28. to analyze the fluid characteristics at the above-mentioned mesoscopic scale. The organizational framework of the model proposed in the paper is obtained by dimensional analysis of the smooth circular pipe flow problem. The relevant physical parameters include pipe length L and inner diameter D, fluid density ρ and viscosity μ, average flow velocity U, and pressure difference Δp. These six quantities can be regarded as one dependent variable and five independent variables, such as .

[0077] By using the Buckingham Pi theorem and noting that the three dimensions involved: mass, length, and time, the five independent dimensional quantities can be simplified to two dimensionless groups. The dependent variable can also be dimensionless, resulting in a total of three dimensionless groups, any of which can be viewed as a function of the other groups. Following common practice, the flow Reynolds number is chosen to be and pipe aspect ratio As independent variables, these variables determine the Darcy friction factor:

[0078] (2)

[0079] The latter is a dimensionless form of the pressure drop, where the applied gradient is affected by the inertial term associated with fully developed turbulence. Therefore, all pipe flow conditions can be represented by the function To express.

[0080] Corresponds to The classical limit of the domain can be explained by scaling the terms in the Navier–Stokes equations. The balance between the pressure drop gradient, inertial and viscous effects, each of which scales with the dimensional variables. The studied limit of pipe flow corresponds to this balance where the gradient dominates over one effect, with the other effects playing a negligible role.

[0081] For example, as with a mosquito sucking blood through its proboscis, the first case is suitable for well-developed laminar flow, with an imposed gradient Used to balance viscous drag , which yields the Hagen–Poiseuille law applicable to sufficiently slow flows through long, thin pipes, i.e., low and high α. It can be expressed in dimensionless form as , and does not depend on α. ​​In the second case, just as an elephant sucking water with its trunk may satisfy this turbulent attraction, the classical pipe flow turbulence corresponds to the applied gradient Transverse inertia gradient to the pipe axis This is suitable for fast flows and slender pipes, i.e. high and high α. The dimensionless form is , and is independent of and α. The third case, like pursed lips for drinking water, is related to Torricelli's law for flow through an orifice or a very short pipe, i.e., low α, in which case Used to overcome the inertial gradient along the pipe axis The dimensionless form is , and is independent of . This can be roughly thought of as forming a very short pipe.

[0082] These rules are appropriate The proposed model provides good predictions over the entire range of parameter values. and , all existing laws do not apply, and the model is still able to accurately calculate its fluid friction, pressure-flow relationship and other characteristics. Given the data in the paper and the actual implementation of the above technical solutions, the model can be considered to have successfully provided a critical The calculation of the hydrodynamic losses in a finite length pipe provides a high level of accuracy in the prediction.

[0083] One of the main results of this work in this paper is that the three cases are structurally interesting on the unified model constructed in the paper, with their boundaries adjacent in a triple point-like region. In addition, the typical results of the test results of the above technical solutions are The values ​​of and α are also shown to be close to this adjacent region. Although the actual fluid state is different from the idealized pipe flow problem studied here, this practical situation can serve as an auxiliary prediction and calculation at the boundary between the studied hydraulic region and the "inapplicable region" where the traditional relationship is therefore not applicable. This background also inspired the authors to construct a general hydraulic model that is supported and verified by experimental measurement information and spans these adjacent regions to provide an approximate pressure-flow relationship for critical cases.

[0084] This paper proposes such a model to explain the fluid dynamics of pipes with different aspect ratios at different flow rates, especially pipes in between classical flow regimes. The ultimate goal is to obtain a general functional model This paper adopts a mixed theoretical and empirical approach to unify and integrate many previous descriptions of smooth pipe hydraulics, especially the features of flow through orifices, flow in the inlet region, developing and fully developed laminar and turbulent regimes, and the transition from laminar to turbulent flow. In the model structure and parameter selection, the paper cites theory and observations as much as possible. In other aspects, for reasons of mathematical simplicity or convenience, the model takes the following general form:

[0085] (3)

[0086] in , and is a function that captures the individual contributions of inlet effect, laminar flow, and turbulence to the friction factor. This construction is motivated by the fact that inlet effect contributes in all conditions in all pipes and therefore space, while laminar and turbulent effects are relatively independent and only Applicable in different ranges.

[0087] here, and is the selection function, when They take on the value 1 deep into the laminar and turbulent regimes, respectively, and are zero elsewhere. We use a logistic function for this, which behaves like a smoothed Heaviside or step function:

[0088] (4)

[0089] as well as

[0090] (5)

[0091] here, is the critical Reynolds number for the transition from laminar to turbulent flow, and δ can be interpreted as The width or range over which the transition occurs. Parameter value * = 2000 is consistent with the literature on the transition in the presence of sufficiently strong perturbations. The choice of δ = 200 was shown to match the experimental data well.

[0092] The paper then defines the contributing friction terms starting from the inlet effect. In the short pipe or orifice limit α→0, the acceleration effect dominates and the applied pressure gradient is subsumed into the axial inertia gradient, i.e. As described by Bernoulli's principle and Torricelli's law, water is generally an ideal inviscid fluid in the form of , or equivalently, The actual outflow velocity is slightly lower due to streamline contraction and viscous effects. These complexities determine the discharge coefficient CD ≤ 1, or the ratio of the actual to the ideal outflow velocity, whose value depends on and the geometric details of the orifice. We assume a constant CD = 0.85, so This parameter value falls within a wide range reported in previous studies, between 0.6 and 1.0, and was chosen in a satisfactory manner to explain the low α fraction in the experimental dataset.

[0093] Contribution to laminar flow The consideration must include the development flow far away from the pipe as well as the development flow in the inlet area. and high α, the developing laminar flow involves the applied pressure balancing the viscous stresses, The developing flow profile is parabolic and the hydraulics are described by the Hagen-Poiseuille law, namely:

[0094] (6)

[0095] This is equivalent to The cumulative pressure drop factor in the inlet region due to viscous and inertial effects is With the flow coordinate increases with the increase of Much longer than the hydrodynamic inlet length When , its value tends to a value of an order of magnitude. Associated with L and reconstructed in units of α, we obtain:

[0096] (7)

[0097] in ,for ,but .

[0098] We assume the exponential form of b and use the empirical formula , as the inlet length at which the flow profile approaches a developed parabolic profile within 99%, with k = 0.05. Therefore, the friction contribution due to developing and fully developed laminar flow is given by:

[0099] (8)

[0100] in is a simple choice that will be shown to be in good agreement with the experimental data. Previous theoretical studies have suggested values ​​in the range 1.2–1.4, while experiments agree with slightly lower values ​​of 1–1.2.

[0101] Finally, consider applying a sufficiently high The fully developed turbulence for a long pipe or high α involves the applied pressure gradient being balanced with the inertial gradient across the pipe, corresponding to , which produces a uniform and constant Extensive characterization showed ,and Follow More sensitive to changes. or In the critical case, the influence of turbulent flow development has been shown to no longer be confined to a relatively short inlet region, whose length right is relatively sensitive. Since the increased pressure drop due to development and inlet effects occurs in the same region of the pipe and cannot be clearly distinguished, a simplifying assumption is made that the former does not lead to an additional contribution. Therefore, our turbulent state model only considers fully developed flows, which is consistent with the constant Related, for In the case of , the previously measured values ​​of 0.03~0.05 are representative. In summary, the complete model form is:

[0102] (9)

[0103] Especially for the critical value or , many existing laws do not apply, and the influence of turbulent flow development has been shown to no longer be limited to a relatively short inlet region, whose length Re is relatively sensitive, and the above model can accurately calculate fluid friction, pressure-flow relationship and other characteristics. Among them, the six parameters and their values ​​are = 0.85, Re∗ = 2000, δ = 200, b∞ = 1, k = 0.05 and =0.04. The pipe diameter is the upper limit of the inner diameter of the first moving pipe 21 or the third moving pipe 23, which is 2 mm. At present, the detection speed of the whole machine of the cell parameter joint analyzer is getting faster and faster, resulting in the flow velocity in the pipe, especially the local flow velocity, which may exceed 20 m / s. Therefore, the Reynolds number of the fluid flow state in the pipe has a greater probability of falling into the critical interval. or , and then substitute other empirical parameters into the above formula, and multiply the calculated length of the third motion pipeline 23 by a certain redundancy coefficient (selected as 3 according to experience), then the length of the third motion pipeline 23 is 0.4931m. After appropriate rounding, the length of the third motion pipeline 23 should be greater than or equal to 500mm.

[0104] In summary, we have considered the actual motion process of transient transition flow, analyzed the change of liquid momentum due to liquid compressibility in the dynamic process, and established a dynamic mathematical model of the valve-controlled hydraulic system for the problem of fluid oscillation impact in the valve-controlled hydraulic system. Using the one-dimensional fluid transient theory, we numerically analyzed the transient flow of the hydraulic system pipeline components, gave the calculation method of the mathematical model, and then obtained the optimal parameters required by the system. The experiment also verified the accuracy of the constructed model.

[0105] Optionally, the ratio of the length of the third motion pipeline 23 to the length of the first motion pipeline 21 is greater than 3. As mentioned above, when the slide assembly 5 moves in the horizontal direction, the third motion pipeline 23 will bend or straighten significantly, so the moving distance of the slide assembly 5 in the horizontal direction will be limited by the third motion pipeline 23. This embodiment increases the length of the third motion pipeline 23 by limiting the ratio of the length of the third motion pipeline 23 to the length of the first motion pipeline 21, so as to expand the moving distance of the slide assembly 5. The movement of the slide assembly 5 in the horizontal direction is to sample the multiple sample pools in the cell parameter joint analyzer A. Therefore, expanding the moving distance of the slide assembly 5 means that the number of sample pools in the cell parameter joint analyzer A can be expanded, thereby improving the practicality and detection efficiency of the cell parameter joint analyzer A.

[0106] In one embodiment, the ratio of the length of the third motion pipeline 23 to the length of the first motion pipeline 21 is preferably 5.

[0107] In summary, in the embodiment of the present application, by limiting the tube lengths and inner diameters of the first moving pipeline 21, the second fixed pipeline 22, and the third moving pipeline 23 in the pipeline assembly 2, the disturbance of the sample in the pipeline assembly 2 is reduced, and the detection efficiency and accuracy of the cell parameter joint analyzer A for the sample are improved.

[0108] Optionally, as described above, the two-dimensional motion component 1 is a double-ended open cylinder, see Figure 4 , Figure 4 1 is a schematic diagram of the structure of an embodiment of the two-dimensional motion assembly 1 of the present application. The radial cross-sectional area of ​​the upper end of the double-ended open cylinder 11 is larger than the radial cross-sectional area of ​​the lower end of the double-ended open cylinder 11, and the inner diameter of the lower end of the double-ended open cylinder 11 is smaller than the inner diameter of the upper end of the double-ended open cylinder 11, that is, Figure 4 The distance D1 is smaller than the distance D2. The upper end of the double-ended open cylinder 11 is connected to the first motion pipeline 21, and the lower end of the double-ended open cylinder 11 is the end away from the first motion pipeline 21. The radial cross-sectional area here refers to the radial cross-sectional area of ​​the internal cavity of the two-dimensional motion component 1 (excluding the inner and outer walls of the cylinder).

[0109] When the Reynolds number increases, two unstable modes will appear in the laminar flow, one is the axial mode, that is, the disturbance propagates along the axial direction of the pipeline; the other is the circumferential mode, that is, the disturbance propagates along the circumferential direction of the pipeline. The critical Reynolds numbers, corresponding wavelengths and frequencies of the above two modes are different, and the end effect has different effects on the two modes: the axial mode is mainly affected by the ratio of the length to the diameter of the pipeline, so increasing the inner diameter of the tube is conducive to reducing the axial impact. Specifically, the lower end of the double-ended open cylinder 11 can enter the sample holding tube to absorb the sample, and then transport the sample to the first motion pipeline 21. Since the radial cross-sectional area of ​​the upper end of the double-ended open cylinder 11 is larger than the radial cross-sectional area of ​​the lower end of the double-ended open cylinder 11, in the process of the sample flowing from the lower end of the double-ended open cylinder 11 through the upper end of the double-ended open cylinder 11, due to the increase in the cross-sectional area of ​​the flow, the flow velocity of the sample in the double-ended open cylinder 11 becomes smaller accordingly, and then the energy of the axial impact is smaller, which can effectively reduce the disturbance of the sample during transportation.

[0110] Optionally, the lower end opening of the double-ended open cylinder 11 is arranged on the side wall of the double-ended open cylinder 11, and then after the double-ended open cylinder 11 absorbs the sample, there is a certain angle between the transport direction of the sample entering the double-ended open cylinder 11 through the lower end opening and the transport direction of the sample in the double-ended open cylinder 11, which can further reduce the flow velocity of the sample in the double-ended open cylinder 11, and then the smaller the energy of the axial impact, the less disturbance of the sample during the transmission process.

[0111] Moreover, under normal circumstances, when the sample holding tube is not being sucked for sample by the two-dimensional motion component 1, a soft cover will be provided at the opening of the sample holding tube. When the two-dimensional motion component 1 needs to suck the sample in the sample holding tube, the lower end of the double-ended opening cylinder 11 needs to puncture the soft cover first, and then enter the sample holding tube to suck the sample. Therefore, in this embodiment, it is proposed that the lower end opening is provided on the side wall of the double-ended opening cylinder 11, which can effectively avoid the debris generated by the puncture from clogging the lower end opening during the process of puncturing the soft cover at the lower end of the double-ended opening cylinder 11, thereby affecting the sample sucking operation of the double-ended opening cylinder 11, thereby improving the operating efficiency and stability of the two-dimensional motion component 1.

[0112] Optionally, the outer wall of the double-ended open cylinder 11 is provided with a plurality of axially symmetrical grooves 12, the grooves 12 are in the shape of long strips, and the grooves 12 are extended along the extension direction of the double-ended open cylinder 11, so that in the process of absorbing the sample in the sample holding tube at the lower end of the double-ended open cylinder 11, the sample holding tube and the outside world can exchange gas through the grooves 12, thereby ensuring the stability of the double-ended open cylinder 11 in absorbing the sample.

[0113] In general, the lower end opening of the double-ended open cylinder 11 is arranged on the side wall of the double-ended open cylinder 11, that is, a hard metal needle (side opening) is generally used to impact the soft cover of the sample holding tube to prevent the liquid surface from being directly impacted by the test tube cap and then impacted by the liquid in the test tube, thereby reducing the axial impact, and the double-ended open cylinder 11 has a groove 12 as a venting groove to reduce the needle impact and further reduce the axial impact force.

[0114] Optionally, the minimum distance between the double-ended open cylinder 11 and the second fixed pipeline 22 is less than 50 mm. Specifically, the minimum distance between the double-ended open cylinder 11 and the second fixed pipeline 22 exists when both the double-ended open cylinder 11 and the second fixed pipeline 22 are arranged on the slide assembly 5. At this time, since the second fixed pipeline 22 is arranged on the slide assembly 5 in the vertical direction, and the double-ended open cylinder 11 is also extended in the vertical direction, the minimum distance between the double-ended open cylinder 11 and the second fixed pipeline 22 is the distance between the double-ended open cylinder 11 and the second fixed pipeline 22 in the horizontal direction when both the double-ended open cylinder 11 and the second fixed pipeline 22 are arranged on the slide assembly 5. And since the minimum distance between the double-ended open cylinder 11 and the second fixed pipeline 22 is less than 50 mm, as Figure 3 As shown, the first end is connected to the upper end of the double-end open cylinder 11, and the second end is connected to the second fixed pipeline 22. The first moving pipeline 21 is bent and arranged between the two. The greater the setting curvature of the first moving pipeline 21, the more curved the pipeline through which the sample flows, the greater the energy consumption due to the change of flow direction during the flow, and the smaller the energy used for axial impact, that is, the flow velocity becomes smaller, which reduces the disturbance of the sample in the first moving pipeline 21.

[0115] Optionally, the interference reduction component 3 includes a driving component and an interference reduction member (not shown), and the driving component is connected to the second end of the third motion pipeline 23 through the interference reduction member, wherein the driving component can be the syringe mentioned above, so as to drive the sample or liquid to enter the interference reduction member, or the syringe, through the two-dimensional motion component 1, the first motion pipeline 21, the second fixed pipeline 22 and the third motion pipeline 23. The angle between the direction of the liquid flowing into the inlet end of the interference reduction member and the direction of the liquid flowing out of the outlet end of the interference reduction member is greater than or equal to 180. Specifically, in the process of liquid entering the disturbance reducing element through the third movement pipeline 23, since the angle between the direction of liquid flowing into the inlet end of the disturbance reducing element and the direction of liquid flowing out of the outlet end of the disturbance reducing element is greater than or equal to 180, that is, the internal flow pipeline of the disturbance reducing element has a certain curvature, and the more curved the pipeline through which the liquid flows, the greater the energy consumed due to the change in flow direction during the flow, and the smaller the energy used for axial impact, that is, the flow velocity becomes smaller, which reduces the disturbance of the liquid in the disturbance reducing element, thereby further improving the measurement efficiency and accuracy of the cell vertical parameter measurement component 6 for the sample.

[0116] In summary, by setting the structures of the two-dimensional motion component 1 and the disturbance reduction component, as well as the distance between the two-dimensional motion component 1 and the second fixed pipeline 22, the stability of the two-dimensional motion component 1 during sample aspiration is improved, the disturbance of the sample during transportation, especially the axial impact, is reduced, and the detection efficiency and accuracy of the cell parameter combined analyzer A are improved.

[0117] The disturbance reducing member can be spaced apart from the slide rail assembly 4 to separate the disturbance reducing member from the moving slide assembly 5, thereby avoiding the disturbances of the disturbance reducing member and the slide assembly 5 from interfering with each other, thereby reducing the disturbance of the sample in the pipeline.

[0118] Among them, the interference reduction component is a long-open valve, that is, when the driving component generates pressure to the two-dimensional motion component 1 and the pipeline component 2, there is no need for the interference reduction component to frequently switch the switch to cooperate, thereby avoiding aging and damage of the valve of the interference reduction component and improving the stability of the interference reduction component 3.

[0119] Optionally, the response time of the interference reducer is less than 80ms, that is, the time taken by the interference reducer from receiving the electrical signal to open the valve to switching to the open state is less than 80ms; or the time taken by the interference reducer from receiving the electrical signal to close the valve to switching to the closed state is less than 80ms; or the power switch is turned on, and the pressure sensor measures the pressure change at the outlet of the interference reducer (such as a solenoid valve), and the fast response time measuring instrument measures the interval time from the moment the interference reducer is energized when it receives the electrical signal to open the valve to the pressure rising to a fixed proportion (such as 90% or 80%) of the maximum value, which is the opening response time of the solenoid valve.

[0120] Among them, during the switching of the valve core inside the disturbance reducer, the liquid inside the disturbance reducer will be disturbed. Therefore, the response time of the disturbance reducer can also be the time for disturbing the liquid flow inside the disturbance reducer. By shortening the response time of the disturbance reducer, the disturbance to the liquid can be effectively reduced.

[0121] Optionally, the maximum action volume of the disturbance reducer is less than 5uL, that is, the maximum flow rate of the disturbance reducer is less than 5uL, the end inner diameter of the disturbance reducer is small, and the driving end face area is small, that is, the inner diameter of the tube is small as described above, thereby reducing the disturbance of the liquid inside the disturbance reducer.

[0122] Optionally, the length of the connecting tube between the disturbance reducing member and the driving assembly is greater than 30 mm, so as to reduce the end effect of the liquid between the disturbance reducing member and the driving assembly and reduce the disturbance of the liquid.

[0123] In one embodiment, the inner diameter of the inlet end of the disturbance reducer is less than or equal to the inner diameter of the third moving pipeline 23. By reducing the inner diameter of the end of the disturbance reducer, the axial impact of the end face of the liquid when entering the interior of the disturbance reducer from the third moving pipeline 23 is reduced, thereby reducing the disturbance of the liquid.

[0124] In another embodiment, the end inner diameter of the port where the drive assembly is connected to the disturbance reducer is less than or equal to the inner diameter of the tube of the third motion pipeline 23. It can be understood that the port where the drive assembly is connected to the disturbance reducer is also the outlet end of the disturbance reducer and the inlet end of the drive assembly, that is, the end inner diameter of the outlet end of the disturbance reducer and the end inner diameter of the inlet end of the drive assembly are less than the inner diameter of the tube of the third motion pipeline 23. It can be obtained from the foregoing that the end inner diameter of the inlet end of the disturbance reducer is less than or equal to the inner diameter of the tube of the third motion pipeline 23, further limiting the end inner diameter of the port where the disturbance reducer is connected to the drive assembly to be less than or equal to the inner diameter of the tube of the third motion pipeline 23, thereby avoiding the increase of the end face axial impact due to the increase of the end inner diameter when the liquid flows through the disturbance reducer and the drive assembly, thereby reducing the disturbance of the liquid in the disturbance reducer and the drive assembly.

[0125] Optionally, the pipe material of the first motion pipeline 21 is at least one of polyetheretherketone, polytetrafluoroethylene, polyethylene and polypropylene, wherein polyetheretherketone is a material with excellent properties such as high temperature resistance, self-lubrication, easy processing and high mechanical strength; polytetrafluoroethylene is a material that is resistant to high temperature, acid and alkali, and various organic solvents, and is almost insoluble in all solvents; polyethylene is a material with good chemical stability, resistance to most acids and alkalis, and insoluble in general solvents at room temperature; polypropylene is a material with high impact resistance, strong mechanical properties, and resistance to corrosion by various organic solvents and acids and alkalis. The pipe material of the first motion pipeline 21 can be selected from one of the above materials, or two or more of the above materials can be selected to mix to combine the excellent properties of the materials.

[0126] As mentioned above, the first end of the first motion pipeline 21 will move with the movement of the two-dimensional motion component 1 in the vertical direction. Therefore, when selecting the pipeline material of the first motion pipeline 21, the flexibility of the material needs to be considered to avoid interference with the movement of the two-dimensional motion component 1 and to avoid the first motion pipeline 21 falling off the two-dimensional motion component 1 during the movement of the two-dimensional motion component 1, thereby improving the safety of the movement of the two-dimensional motion component 1. At the same time, since the sample will be passed into the first motion pipeline 21, the corrosion resistance of the material needs to be considered. The user can select at least one of the above materials based on the needs, and this application does not limit this.

[0127] Optionally, the inner wall roughness of the first motion pipeline 21 is less than or equal to 0.8 μm. By limiting the inner wall roughness of the first motion pipeline 21 , the resistance encountered by the sample in the first motion pipeline 21 is reduced, thereby alleviating the disturbance of the sample.

[0128] Optionally, the pipe material of the second fixed pipe 22 is at least one of polyetheretherketone, polytetrafluoroethylene, polyethylene and polypropylene, which can enable the light beam generated by the cell vertical parameter measurement component 6 to enter the second fixed pipe 22 to detect the cell vertical parameters of the sample, thereby improving the measurement accuracy of the cell vertical parameter measurement component 6.

[0129] In one embodiment, the transmittance of the second fixed pipeline 22 is greater than or equal to 90%, and the haze is less than or equal to 5%, so that almost all of the light beams emitted by the cell vertical parameter measurement component 6 enter the second fixed pipeline 22 for detection, thereby improving the measurement accuracy of the cell vertical parameter measurement component 6.

[0130] Optionally, the pipeline material of the third motion pipeline 23 is at least one of polyetheretherketone, polytetrafluoroethylene, polyethylene and polypropylene. It can be obtained from the above that when the slide assembly 5 moves in the horizontal direction, it will drive the third motion pipeline 23 to bend or straighten. Therefore, the pipeline flexibility of the third motion pipeline 23 is required to be relatively high, so as to avoid the third motion pipeline 23 not bending in place during the movement of the slide assembly 5, thereby affecting the movement of the slide assembly 5, or causing the third motion pipeline 23 to break or fall off, thereby improving the safety of the movement of the slide assembly 5 and improving the practicality of the cell parameter combined analyzer A.

[0131] Optionally, the inner wall roughness of the third motion pipeline 23 is less than or equal to 0.8 μm. By limiting the inner wall roughness of the third motion pipeline 23 , the resistance encountered by the liquid in the third motion pipeline 23 is reduced, thereby alleviating the disturbance of the liquid.

[0132] Optionally, the minimum distance between the two-dimensional motion component 1 and the second fixed pipeline 22 is greater than 10 mm. As described above, the minimum distance between the two-dimensional motion component 1 and the second fixed pipeline 22 is the horizontal distance between the two-dimensional motion component 1 and the second fixed pipeline 22 when both the two-dimensional motion component 1 and the second fixed pipeline 22 are arranged on the slide assembly 5. The minimum distance between the two-dimensional motion component 1 and the second fixed pipeline 22 is greater than 10 mm, that is, when the two-dimensional motion component 1 and the second fixed pipeline 22 are both arranged on the slide assembly 5, there is a large distance between the two-dimensional motion component 1 and the second fixed pipeline 22, so as to avoid the two-dimensional motion component 1 from causing wear to the second fixed pipeline 22 when moving in the vertical direction. It can be understood that the minimum distance between the two-dimensional motion component 1 and the second fixed pipeline 22 is the same distance as the minimum distance between the double-end open cylinder 11 and the second fixed pipeline 22.

[0133] At the same time, a setting position is reserved for the cell vertical parameter measurement component 6 to avoid the two-dimensional motion component 1 and the second fixed pipeline 22 being located at a too small distance on the slide assembly 5, and the first motion pipeline 21 being excessively bent, which affects the transportation of the sample in the first motion pipeline 21, thereby improving the coordination efficiency between the two-dimensional motion component 1 and the pipeline component 2.

[0134] Optionally, the tube length of the first motion pipeline 21 is greater than 70 mm. By limiting the tube length of the first motion pipeline 21, it is convenient to replace the two-dimensional motion component 1 multiple times. The two-dimensional motion component 1 is a wearing part and often needs to be replaced. The two-dimensional motion component 1 and the first motion pipeline 21 are often bonded by glue. Therefore, the pipeline end of the first motion pipeline 21 must be destroyed during replacement (generally, a section of the interface pipeline that has been bonded at the end can be cut off).

[0135] In a practical application, when the cell parameter combined analyzer A needs to replace the double-ended open cylinder 11, the portion where the first end of the first motion pipeline 21 is connected to the double-ended open cylinder 11 is cut off, and then the end of the new first end of the first motion pipeline 21 is connected to the new double-ended open cylinder 11. That is, in the process of multiple replacements of the double-ended open cylinder 11 by the cell parameter combined analyzer A, the tube length of the first motion pipeline 21 will gradually decrease. Therefore, this embodiment proposes that the tube length of the first motion pipeline 21 is greater than 70 mm, which ensures that the tube length of the first motion pipeline 21 is sufficient during the replacement of the double-ended open cylinder 11. The user does not need to replace the entire first motion pipeline 21, but only needs to cut off a section of the pipeline, thereby simplifying the operation of replacing the double-ended open cylinder 11 and improving the user experience.

[0136] Since the first moving pipeline 21 has a certain curvature and one end thereof needs to move along with the vertical movement of the double-ended open cylinder 11, it must have a certain basic pipe length. Adding the additional pipe length, the pipe length of the first moving pipeline 21 should be greater than 70 mm. The additional pipe length is obtained by multiplying the number of possible replacements of the double-ended open cylinder 11 within the maintenance period by the end pipe length cut off each time, plus a certain margin.

[0137] Optionally, a sleeve is provided outside the first motion pipeline 21 to protect the first motion pipeline 21. When the two-dimensional motion component 1 drives the first end of the first motion pipeline 21 to move in the vertical direction, the sleeve can isolate the first motion pipeline 21 from other components close to the first motion pipeline 21 in the cell parameter joint analyzer A, thereby preventing the first motion pipeline 21 from being worn by other components, causing pipeline damage and leakage, and improving the safety of the first motion pipeline 21. It can also reduce the vibration of the first motion pipeline 21 during movement and reduce the disturbance of the sample in the first motion pipeline 21.

[0138] Optionally, the first motion pipeline 21 has two types: an inverted U-shape and an S-shape (ie, two U-shapes combined together):

[0139] The inverted U-shape is that the first moving pipeline 21 is connected to the second fixed pipeline 22 from the upper end in an inverted U shape, the first end of the second fixed pipeline 22 is fixed above the slide assembly 5, and the second end of the second fixed pipeline 22 is fixed below the slide assembly 5. Generally, the tank chain 7 (containing the third moving pipeline 23) is below the slide rail assembly 4.

[0140] In the S-type, the first moving pipeline 21 is connected to the second fixed pipeline 22 from the lower end in an S shape, the first end of the second fixed pipeline 22 is fixed below the slide assembly 5, and the second end of the second fixed pipeline 22 is fixed above the slide assembly 5. Generally, the tank chain 7 (including the third moving pipeline 23) is above the slide rail assembly 4. Generally, the tube length of the S-type first moving pipeline 21 is greater than the tube length of the inverted U-shaped first moving pipeline 21. Therefore, the tube length of the S-type first moving pipeline 21 is generally greater than 100 mm.

[0141] Optionally, the distance between the measuring position of the cell vertical parameter measurement component 6 and the first end of the second fixed pipeline 22 is greater than or equal to 10 mm; the distance between the measuring position of the cell vertical parameter measurement component 6 and the second end of the second fixed pipeline 22 is greater than or equal to 10 mm. Specifically, since ambient light may enter the end of the second fixed pipeline 22, thereby affecting the measurement accuracy of the cell vertical parameter measurement component 6, if the cell vertical parameter measurement component 6 detects samples of all pipeline sections of the second fixed pipeline 22, the accuracy of the detection result cannot be guaranteed. Therefore, it is necessary to set the distance between the measuring position of the cell vertical parameter measurement component 6 and the end of the second fixed pipeline 22.

[0142] Furthermore, considering the relationship between the rate at which the sample is subjected to gravity drop in the second fixed pipeline 22 and the measuring position of the cell vertical parameter measurement component 6, experiments have shown that the cell vertical parameters of the sample are detected in the pipeline section where the distance between the measuring position of the cell vertical parameter measurement component 6 and the first end of the second fixed pipeline 22 is greater than or equal to 10 mm; and the distance between the measuring position of the cell vertical parameter measurement component 6 and the second end of the second fixed pipeline 22 is greater than or equal to 10 mm, which can obtain better detection effects and improve the measurement accuracy of the cell vertical parameter measurement component 6.

[0143] Optionally, the cell parameter combined analyzer A includes multiple sample holding pools and control modules (not shown). The sample holding pools are used to load samples and can be used as a place for sample reactions, preparation of samples to be tested, or a place for sample testing.

[0144] The control module is connected to the slide assembly 5 and is used to control: in the process of the two-dimensional motion assembly 1 distributing samples to multiple sample holding pools, the maximum movement speed of the slide assembly 5 sliding in the horizontal direction on the slide rail assembly 4 is less than 20m / s, so as to avoid the slide assembly 5 moving too fast, which may affect the stability of the pipeline assembly 2 and increase the disturbance of the samples transported in the pipeline assembly 2, thereby ensuring the stability of the samples during the transportation of the pipeline assembly 2, reducing the disturbance of the samples, and improving the detection efficiency and accuracy of the cell parameter combined analyzer A.

[0145] Optionally, the horizontal sliding length of the slide assembly 5 is greater than 200 mm, ensuring that more sample pools can be accommodated near the slide rail, so that the cell parameter combined analyzer A can have more combined detection items and adapt to more detection scenarios.

[0146] Among them, since the sample absorbed by the two-dimensional motion component 1 will participate in the measurement process of the cell vertical parameter measurement component 6 and will be injected into the sample holding pool respectively, in actual application, according to the total amount of sample demand, the driving component can provide negative pressure to the pipeline component 2 and the two-dimensional motion component 1, and the sample in the sample holding tube enters the two-dimensional motion component 1 due to the negative pressure, and enters the pipeline component 2. After the sample fills the second fixed pipeline 22, the driving component can stop generating pressure to allow the sample to stay in the second fixed pipeline 22. The cell vertical parameter measurement component 6 then detects the cell vertical parameters of the sample in the second fixed pipeline 22. After the cell vertical parameter measurement component 6 completes the detection, the slide assembly 5 and the two-dimensional motion component 1 move in coordination, and the two-dimensional motion component 1 moves to the top of the sample holding pool where sample separation is required. The driving component generates positive pressure. Under the action of the positive pressure, the sample in the pipeline component 2 enters the sample holding pool via the two-dimensional motion component 1 to complete the sample separation.

[0147] Alternatively, the driving component can provide negative pressure to the pipeline component 2 and the two-dimensional moving component 1, and the sample in the sample holding tube enters the two-dimensional motion component 1 due to the negative pressure. After the total amount of sample demand meets the requirement, the driving component can stop generating pressure (at this time, the sample may enter the pipeline component 2), and then the slide assembly 5 and the two-dimensional motion component 1 move together, and the two-dimensional motion component 1 moves to the top of the sample holding pool where sample splitting is required. The driving component generates positive pressure. Under the action of the positive pressure, the sample in the pipeline component 2 enters the sample holding pool through the two-dimensional motion component 1, and the sample splitting is completed. After the sample splitting is completed, the slide assembly 5 and the driving component both stop moving (even after remaining stationary for a period of time). At this time, because the sample holding pool is split first, the second fixed pipeline 22 may not be completely filled with samples. The driving component continues to generate negative pressure, and after the sample enters the second fixed pipeline 22 through the first motion pipeline 21, the cell vertical parameter measurement component 6 immediately detects the cell vertical parameters of the sample in the second fixed pipeline 22. The slide assembly 5 and the driving component do not start a new movement until the detection of the cell vertical parameters is completed.

[0148] Compared with measuring the cell vertical parameters first and then dividing the samples, dividing the samples first and then measuring the cell vertical parameters can effectively shorten the sample detection time in the cell parameter joint analyzer A. Specifically, if the samples are divided first, the samples in the sample pool can be operated accordingly while the cell vertical parameter measurement component 6 is measuring the cell vertical parameters of the samples; and if the cell vertical parameter measurement of the samples is performed first, it is necessary to wait until the cell vertical parameter measurement is completed before dividing the sample pool and performing the corresponding operation. Therefore, considering the operating efficiency of the cell parameter joint analyzer A, it is preferred to divide the samples first and then detect the cell vertical parameters.

[0149] Optionally, the cell parameter joint analyzer A further comprises a partition 8 and a positioning plate 9, the partition 8 is vertically arranged in the cell parameter joint analyzer A, the positioning plate 9 is fixedly arranged on the partition 8, and the slide rail assembly 4 is fixedly arranged on the positioning plate 9. Further, the interference reduction assembly 3 can be arranged on the partition 8, and the slide rail assembly 4 and the interference reduction assembly 3 are arranged at a relatively large interval to further separate the slide rail assembly 4 from the interference reduction assembly 3, so as to avoid the disturbance generated by the movement of the slide seat assembly 5 and the operation of the interference reduction assembly 3 from interfering with each other, thereby reducing the disturbance to the sample.

[0150] Optionally, the two horizontal edges of the positioning plate 9 are provided with curling edges, wherein the horizontal edges of the positioning plate 9 are also the two opposite side edges of the positioning plate 9 parallel to the second direction Y. By providing curling edges on the two horizontal edges of the positioning plate 9, the two horizontal edges of the positioning plate 9 are rolled up, thereby improving the strength of the positioning plate 9 and avoiding deformation of the positioning plate 9, which affects the smooth movement of the slide assembly 5 and causes disturbance to the sample in the pipeline assembly 2.

[0151] Optionally, at least one vertical edge of the positioning plate 9 is provided with a rolled edge, wherein the vertical edge of the positioning plate 9 is also the side edge of the positioning plate 9 parallel to the first direction X. By providing a rolled edge on at least one vertical edge of the positioning plate 9, the strength of the positioning plate 9 is further improved, the smoothness of the movement of the slide assembly 5 is improved, and the disturbance to the sample is reduced.

[0152] Optionally, an optical coupling component (not shown) is provided on the slide assembly 5 to position the movement of the slide assembly 5 and improve the movement accuracy of the slide assembly 5 .

[0153] In one embodiment, the optical coupling assembly includes a light emitting module and a photoelectric conversion module, and both the light emitting module and the photoelectric conversion module are arranged on the slide assembly 5, that is, the light emitting module and the photoelectric conversion module will move along with the movement of the slide assembly 5. For example, but not limited to, a shielding plate corresponding to the sample pool may also be arranged on the positioning plate 9, and when the slide assembly 5 moves to the area corresponding to the sample pool, the shielding plate will shield the light beam emitted by the light emitting module to the photoelectric conversion module, and the photoelectric conversion module cannot receive the light beam emitted by the light emitting module, and then in response to the slide assembly 5 moving into position, the slide assembly 5 can sample the sample pool. By setting the light emitting module and the photoelectric conversion module, the movement accuracy of the slide assembly 5 can be effectively improved.

[0154] Furthermore, since the movement accuracy of the slide assembly 5 is relatively high and the optical coupling assembly is used to ensure the control accuracy of the slide assembly 5 during movement, the stability of the movement of the slide assembly 5 driving the two-dimensional motion assembly 1 to multiple sample pools for sample sorting is ensured, thereby avoiding the situation where the two-dimensional motion assembly 1 cannot move above the sample pool, and also avoiding the situation where the two-dimensional motion assembly 1 collides with adjacent devices during movement and causes damage, thereby improving the efficiency of the two-dimensional motion assembly 1 in sorting samples for the sample pools and improving the practicality of the cell parameter combined analyzer A.

[0155] In one embodiment, as described above, the cell parameter combined analyzer A includes a tank chain 7, which is sleeved on the outside of the third moving pipeline 23 to wrap the third moving pipeline 23. When the third moving pipeline 23 is bent, the third moving pipeline 23 is protected to prevent the third moving pipeline 23 from causing wear and tear on other components, damaging the safety of the pipeline, and affecting the operating efficiency of other components, thereby improving the safety of the cell parameter combined analyzer A.

[0156] Optionally, a sleeve is provided on the outer sleeve of the pipe section of the third moving pipeline 23 wrapped by the tank chain 7. The sleeve is arranged inside the tank chain 7 to isolate the tank chain 7 from the third moving pipeline 23, avoid wear between the third moving pipeline 23 and the tank chain 7, further improve the safety of the third moving pipeline 23, and reduce the disturbance of the liquid in the pipeline caused by the movement of the tank chain.

[0157] Optionally, the vertical width of the tank chain 7 is less than or equal to 50 mm, and the length of the tank chain 7 matches the third moving pipeline 23. The specific setting value can be set by the user according to the outer diameter of the third moving pipeline 23, so that the tank chain 7 can better protect the third moving pipeline 23 without affecting the movement of the pipeline or the tank chain. In the process of bending or straightening of the third moving pipeline 23, the tank chain 7 moves with the third moving pipeline 23 to provide protection for the third moving pipeline 23.

[0158] Optionally, the cross-sectional shape of the lower horizontal edge of the positioning plate 9 is U-shaped, wherein, as described above, both horizontal edges of the positioning plate 9 are provided with curled edges, and the curled edges of the lower horizontal edge of the positioning plate 9 can be U-shaped, so as to form a receiving groove at the lower horizontal edge of the positioning plate 9 to receive debris dropped during the movement of the tank chain 7, thereby preventing the debris generated by the tank chain 7 from falling into the sample pool and contaminating the sample pool, thereby improving the safety of the operation of the cell parameter combined analyzer A.

[0159] Optionally, the cross-sectional shape of the upper horizontal edge of the positioning plate 9 is L-shaped. Similarly, it prevents debris generated by the tank chain 7 from falling into the sample pool and contaminating the sample pool, thereby improving the safety of the operation of the cell parameter combined analyzer A.

[0160] Optionally, see Figure 1The positioning plate 9 may be provided with a plurality of positioning grooves 91 , and the positioning grooves 91 may cooperate with the optical coupling assembly to limit the movement of the slide assembly 5 .

[0161] In one embodiment, the number of the plurality of positioning grooves 91 is greater than or equal to the number of the sample holding pools, wherein the positions of the positioning grooves 91 can be set corresponding to the positions of the sample holding pools, such as Figure 1 As shown, the positioning groove 91 can be opened on a horizontal bar on the positioning plate 9, and the light-emitting module can be arranged below the horizontal bar, and the photoelectric conversion module is arranged above the horizontal bar. Then, in the process of the slide assembly 5 driving the optical coupling assembly to move, if it is not moved to the sample pool area, the horizontal bar will block the light beam of the light-emitting module, and if it is moved to the sample pool area, the light beam generated by the light-emitting module will enter the photoelectric conversion module through the positioning groove 91, and the slide assembly 5 will move into place.

[0162] Inside the cell parameter combined analyzer A, there may be other devices that require the devices on the slide assembly 5 to participate in the operation, so corresponding positioning grooves 91 can also be set to ensure the positioning accuracy of the slide assembly 5 at this position. Therefore, this embodiment proposes that the number of positioning grooves 91 is greater than or equal to the number of sample pools to improve the accuracy of the movement of the slide assembly 5 inside the cell parameter combined analyzer A.

[0163] Optionally, part of the edge of the positioning groove 91 is perpendicular to the positioning plate 9. As described above, after the slide assembly 5 moves to the corresponding position, the light beam generated by the light emitting module will enter the photoelectric conversion module through the positioning groove 91, and respond to the movement of the slide assembly 5 into position. This embodiment further proposes that part of the edge of the positioning groove 91 is perpendicular to the positioning plate 9, so that after the slide assembly 5 moves into position, the light beam emitted by the light emitting module can be completely received by the photoelectric conversion module, responding to the movement of the slide assembly 5 into position, thereby improving the accuracy of the optical coupling component's response to the slide assembly 5 in position.

[0164] In another embodiment, if part of the edge of the positioning groove 91 is not perpendicular to the positioning plate 9, for example, part of the edge of the positioning groove 91 is arc-shaped, then when the light beam generated by the light-emitting module passes through the positioning groove 91 and enters the photoelectric conversion module, part of the light beam may be blocked. The photoelectric conversion module receives an incomplete light beam and may not be able to respond accurately, thereby reducing the movement accuracy of the slide assembly 5.

[0165] Optionally, the width of a single positioning groove 91 is smaller than the maximum pool mouth width of the sample pool, wherein, as described above, after the light beam emitted by the light emitting module enters the photoelectric conversion module through the positioning groove 91, the slide assembly 5 moves into place in response, at which time, the slide assembly 5 stops moving, and the two-dimensional motion assembly 1 can perform sample sorting in the sample pool. If the width of the positioning groove 91 is larger than the maximum pool mouth width of the sample pool, it may happen that when the slide assembly 5 stops moving in response to moving into place, the projection of the two-dimensional motion assembly 1 in the vertical direction cannot overlap with the projection of the pool mouth of the sample pool, that is, the movement of the two-dimensional motion assembly 1 in the first direction X is always outside the sample pool, and the sample cannot be injected into the sample pool, which may cause the risk of sample leakage. Here, the pool mouth width refers to the width of the pool mouth of the sample pool in the direction of the slide rail.

[0166] Therefore, this embodiment proposes that the width of a single positioning groove 91 is smaller than the maximum pool opening width of the sample pool. When the light beam emitted by the light emitting module enters the photoelectric conversion module, the two-dimensional motion component 1 is located above the sample pool, thereby improving the efficiency of sample sorting for the sample pool.

[0167] Optionally, the minimum distance between the plurality of positioning grooves 91 is greater than 10 mm, wherein, by setting the distance between the positioning grooves 91, time is reserved for starting and stopping the motor driving the slide assembly 5 to move. If the distance between the positioning grooves 91 is too small, the motor driving the slide assembly 5 to move may not be fully started, and the slide assembly 5 will immediately move to the next positioning groove 91, so that the motor needs to stop immediately, which will affect the operation of the motor. At the same time, since the motor starts and stops in a short time, the motor cannot be fully started, which can easily lead to the occurrence of similar faults such as motor step loss. In order to ensure the accuracy of the movement of the slide assembly 5, the motor needs to be corrected for step loss, which will cause the pipeline to shake sharply and significantly, increase the disturbance to the sample, and further affect the accuracy of the vertical parameters of the cells.

[0168] Therefore, this embodiment proposes that the minimum distance between the plurality of positioning grooves 91 is greater than 10 mm, so as to improve the movement accuracy of the slide assembly 5, while ensuring the smoothness of the movement of the slide assembly 5, thereby improving the practicality of the cell parameter combined analyzer A.

[0169] Optionally, at least a portion of the pipeline area of ​​the pipeline component 2 is filled with a diluent, and after the sample enters the pipeline component 2 through the two-dimensional motion component 1, isolation bubbles exist between the sample and the diluent.

[0170] Before the sample enters the pipeline component 2, the pipeline component 2 may be filled with a diluent to rinse the pipeline area of ​​the pipeline component 2 to prevent the pipeline area from being damaged due to drying and affecting subsequent operations. When the sample enters the pipeline component 2, the negative pressure generated by the drive component will draw the diluent toward the drive component, and the sample enters the pipeline component 2 through the two-dimensional motion component 1. At this time, the diluent is in contact with the sample, and the part of the sample in contact with the diluent will be diluted by the diluent. If the cell vertical parameter measurement component 6 detects the diluted sample, it will affect the detection result.

[0171] Therefore, this embodiment proposes that after the sample enters the pipeline component 2 through the two-dimensional motion component 1, an isolation bubble is provided between the sample and the diluent to isolate the sample from the diluent to prevent the diluent from diluting the sample and affecting the detection result of the sample.

[0172] Specifically, before the two-dimensional motion component 1 absorbs the sample in the sample holding tube, the two-dimensional motion component 1 first absorbs a portion of air into the two-dimensional motion component 1, and then absorbs the sample. At this time, there is an air column between the sample and the diluent, which is an isolation bubble. The sample and the diluent are isolated to avoid cross contamination, thereby improving the detection efficiency and accuracy of the sample and improving the practicability of the cell parameter combined analyzer.

[0173] In summary, the cell parameter joint analyzer A proposed in the present application includes a two-dimensional motion component 1, a pipeline component 2, a disturbance reduction component 3, a slide rail component 4, a slide seat component 5, and a cell vertical parameter measurement component 6. By setting the structure of the two-dimensional motion component 1, the length and inner diameter of the pipeline in the pipeline component 2 are set, the disturbance of the sample during transportation is reduced, and the detection efficiency and accuracy of the cell vertical parameter measurement component 6 on the sample are improved.

[0174] By limiting the structure of the interference reduction component 3 and setting the coordination time between the movement of the slide component 5 and the two-dimensional motion component 1 and the cell vertical parameter measurement component 6, the disturbance of the sample in the pipeline is further reduced, and the detection efficiency and accuracy of the cell parameter combined analyzer A are improved.

[0175] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A cell parameter joint analyzer, characterized in that: The cell parameter joint analyzer comprises a slide rail assembly, a slide seat assembly, a two-dimensional motion assembly, a disturbance reduction assembly, a pipeline assembly and a cell vertical parameter measurement assembly; The slide rail assembly is arranged in the cell parameter combined analyzer along the horizontal direction; The slide seat assembly is slidably disposed on the slide rail assembly to move horizontally along the slide rail assembly; The two-dimensional motion component is a double-end open cylinder, the two-dimensional motion component is slidably arranged in the vertical direction relative to the slide assembly, and the lower end opening of the two-dimensional motion component is used to draw samples from the sample holding tube containing the samples into the pipeline assembly; The interference reduction component is arranged in the cell parameter joint analyzer and connected to the two-dimensional motion component through the pipeline component; The pipeline assembly comprises a first motion pipeline, a second fixed pipeline and a third motion pipeline which are connected in sequence, the upper end opening of the two-dimensional motion assembly is connected to the first end of the first motion pipeline, the second end of the first motion pipeline is connected to the first end of the second fixed pipeline, the second end of the second fixed pipeline is connected to the first end of the third motion pipeline, and the second end of the third motion pipeline is connected to the interference reduction assembly; The cell vertical parameter measurement component is sleeved on the outside of the second fixed pipeline, and is used to measure the cell vertical parameters of the sample in the second fixed pipeline; Wherein, the two-dimensional motion component, the second fixed pipeline and the cell vertical parameter measurement component are arranged on the slide assembly; The length of the first motion pipeline is less than or equal to 400 mm, the inner diameter of the first motion pipeline is less than or equal to 2 mm, and the vertical motion range of the two-dimensional motion component is less than or equal to 200 mm, and the length of the first motion pipeline is greater than the vertical motion range of the two-dimensional motion component; And / or, the length of the second fixed pipeline is greater than or equal to 40 mm, and the inner diameter of the second fixed pipeline is greater than or equal to 0.4 mm; And / or, the length of the third motion pipeline is greater than or equal to 500 mm, and the inner diameter of the third motion pipeline is less than or equal to 2 mm; And / or, a ratio of a length of the third motion pipeline to a length of the first motion pipeline is greater than 3.

2. A cell parameter joint analyzer, characterized in that: The cell parameter joint analyzer comprises a slide rail assembly, a slide seat assembly, a two-dimensional motion assembly, a disturbance reduction assembly, a pipeline assembly and a cell vertical parameter measurement assembly; The slide rail assembly is arranged in the cell parameter combined analyzer along the horizontal direction; The slide seat assembly is slidably disposed on the slide rail assembly to move horizontally along the slide rail assembly; The two-dimensional motion component is a double-end open cylinder, the two-dimensional motion component is slidably arranged in the vertical direction relative to the slide assembly, and the lower end opening of the two-dimensional motion component is used to draw samples from the sample holding tube containing the samples into the pipeline assembly; The interference reduction component is arranged in the cell parameter joint analyzer and connected to the two-dimensional motion component through the pipeline component; The pipeline assembly comprises a first motion pipeline, a second fixed pipeline and a third motion pipeline which are connected in sequence, the upper end opening of the two-dimensional motion assembly is connected to the first end of the first motion pipeline, the second end of the first motion pipeline is connected to the first end of the second fixed pipeline, the second end of the second fixed pipeline is connected to the first end of the third motion pipeline, and the second end of the third motion pipeline is connected to the interference reduction assembly; The cell vertical parameter measurement component is sleeved on the outside of the second fixed pipeline, and is used to measure the cell vertical parameters of the sample in the second fixed pipeline; Wherein, the two-dimensional motion component, the second fixed pipeline and the cell vertical parameter measurement component are arranged on the slide assembly; The radial cross-sectional area of ​​the upper end of the double-end open cylinder is larger than the radial cross-sectional area of ​​the lower end of the double-end open cylinder, the upper end of the double-end open cylinder is connected to the first end of the first motion pipeline, and the lower end of the double-end open cylinder is an end away from the first motion pipeline; And / or, the opening at the lower end of the double-ended open cylinder is arranged on the side wall of the double-ended open cylinder; And / or, a plurality of axially symmetrical grooves are provided on the outer wall of the double-ended open cylinder, the grooves are in the shape of long strips, and the grooves are extended along the extension direction of the double-ended open cylinder; and / or, the minimum distance between the double-ended open cylinder and the second fixed pipeline is less than 50 mm; And / or, the angle between the direction in which the liquid flows into the inlet end of the interference reduction component and the direction in which the liquid flows out of the outlet end of the interference reduction component is greater than or equal to 180°.

3. The cell parameter combined analyzer according to claim 1 or 2, characterized in that: The interference reduction component includes a driving component and a interference reduction member, and the driving component is connected to the second end of the third motion pipeline through the interference reduction member; Wherein, the disturbance reducing member is a long-open valve; and / or, the response time of the interference reduction element is less than 80 ms; and / or, the maximum action volume of the disturbance reducing member is less than 5uL; And / or, the length of the connecting tube between the disturbance reducing member and the driving assembly is greater than 30 mm; And / or, the inner diameter of the inlet end of the disturbance reducing member is less than or equal to the inner diameter of the third moving pipeline; And / or, the inner diameter of the end of the port at which the drive assembly is connected to the interference reducing member is less than or equal to the inner diameter of the third motion pipeline.

4. The cell parameter combined analyzer according to claim 1 or 2, characterized in that: The material of the first motion pipeline is at least one of polyetheretherketone, polytetrafluoroethylene, polyethylene and polypropylene; And / or, the inner wall roughness of the first moving pipeline is less than or equal to 0.8 μm; And / or, the pipe material of the second fixed pipe is at least one of polyetheretherketone, polytetrafluoroethylene, polyethylene and polypropylene; and / or, the light transmittance of the second fixed pipeline is greater than or equal to 90%, and the haze is less than or equal to 5%; And / or, the pipeline material of the third motion pipeline is at least one of polyetheretherketone, polytetrafluoroethylene, polyethylene and polypropylene; And / or, the inner wall roughness of the third motion pipeline is less than or equal to 0.8 μm; And / or, the minimum distance between the two-dimensional motion component and the second fixed pipeline is greater than 10 mm.

5. The cell parameter combined analyzer according to claim 1 or 2, characterized in that: The length of the first motion pipeline is greater than 70 mm; And / or, a sleeve is provided on the outer side of the first movement pipeline.

6. The cell parameter combined analyzer according to claim 1 or 2, characterized in that: The distance between the measuring position of the cell vertical parameter measuring component and the first end of the second fixed pipeline is greater than or equal to 10 mm; The distance between the measuring position of the cell vertical parameter measuring component and the second end of the second fixed pipeline is greater than or equal to 10 mm.

7. The cell parameter combined analyzer according to claim 1 or 2, characterized in that: The cell parameter joint analyzer comprises a plurality of sample holding pools and a control module. The sample holding pools are used to load samples. The control module is connected to the slide assembly. The control module is used to control: In the process of the two-dimensional motion component distributing samples to the plurality of sample holding pools, the maximum movement speed of the slide assembly sliding in the horizontal direction on the slide rail assembly is less than 20 m / s; And / or, the horizontal sliding length of the slide assembly is greater than 200 mm.

8. The cell parameter combined analyzer according to claim 7, characterized in that: The cell parameter joint analyzer comprises a partition and a positioning plate, wherein the partition is vertically arranged in the cell parameter joint analyzer, the positioning plate is fixedly arranged on the partition, and the slide rail assembly is fixedly arranged on the positioning plate; The two horizontal edges of the positioning plate are provided with curling edges; And / or, at least one vertical edge of the positioning plate is provided with a curling edge; And / or, an optical coupling component is provided on the slide assembly; And / or, the optical coupling component includes a light emitting module and a photoelectric conversion module, and the light emitting module and the photoelectric conversion module are both arranged on the slide assembly.

9. The cell parameter combined analyzer according to claim 8, characterized in that: The cell parameter joint analyzer also includes a tank chain, which is sleeved on the outside of the third motion pipeline; And / or, a sleeve is provided on the outer shell of the pipe section of the third moving pipeline wrapped by the tank chain; and / or, the vertical width of the tank chain is less than or equal to 50 mm; And / or, the cross-sectional shape of the lower horizontal side of the positioning plate is U-shaped.

10. The cell parameter combined analyzer according to claim 8, characterized in that: The positioning plate is provided with a plurality of positioning grooves; The number of the plurality of positioning grooves is greater than or equal to the number of the sample holding pools; And / or, part of the edge of the positioning groove is perpendicular to the positioning plate; And / or, the width of a single positioning groove is smaller than the maximum pool opening width of the sample holding pool; And / or, the minimum distance between the plurality of positioning grooves is greater than 10 mm.

Images