Female antibacterial gel and application thereof

Abstract

The invention belongs to the technical field of female nursing materials, and particularly relates to female antibacterial gel and application. The female antibacterial gel is prepared from purified water, a herba patriniae extract, a crape myrtle extract, a dianthus chinensis extract, a hamamelis mollis extract, an oldenlandia diffusa extract, a snowflake lotus extract, a spanishneedles herb extract, a macleaya cordata extract, astaxanthin, hyaluronic acid and trichlorohydroxydiphenyl ether according to a certain weight ratio. The female antibacterial gel is appropriate in smell and color, relatively appropriate in gel viscosity and lubrication degree, good in use feeling, capable of inhibiting staphylococcus aureus, escherichia coli and candida albicans at the same time, good in antibacterial effect and capable of giving consideration to multiple indexes, and the acceptability of the female antibacterial gel can be improved.

Description

Technical Field

[0001] The invention belongs to the technical field of female care products, and in particular relates to a female antibacterial gel and application thereof. Background Art

[0002] It is common and necessary for women to carry out daily health care, mainly because in daily life, there are many factors that make women susceptible to bacterial infection, such as poor personal hygiene habits, sexually transmitted infections, friction from tight clothing, etc., and local flora imbalance caused by changes in hormone levels will also increase the risk of infection. In daily life, in addition to personal good hygiene habits, keeping oneself clean and paying attention to clothing, it is also necessary to use some health care products to resist infection. There are many kinds of care products for women on the market, but the current care products lack multiple indicators such as smell, color, use effect and use experience, which is not conducive to improving the acceptance of care products. The particularity of women's care makes certain requirements for these indicators. Summary of the invention

[0003] The present invention aims to provide a female antibacterial gel, so as to achieve a balance of multiple indicators such as odor, color, use effect and use experience through the female antibacterial gel, thereby improving the acceptance of care products.

[0004] To achieve the above objectives, the present invention adopts the following technical solutions:

[0005] Provided is a female antibacterial gel, which is composed of the following materials in parts by weight:

[0006] 10-13 parts of purified water;

[0007] 4.5-6 parts of Patrinia scabra extract;

[0008] 11-14 parts of crape myrtle extract;

[0009] 7-9 parts of dianthus extract;

[0010] 2.5-4 parts of witch hazel extract;

[0011] 0.8-1.3 parts of Hedyotis diffusa extract;

[0012] 9-12 parts of snowdrop extract;

[0013] Bidens pilosa L. extract 7-9 parts;

[0014] 15-19 parts of Macleaya cordata extract;

[0015] Astaxanthin 11-15 parts;

[0016] 9-11 parts of hyaluronic acid;

[0017] 0.2-0.3 parts of trichlorohydroxydiphenyl ether.

[0018] Preferably, the female antibacterial gel is composed of the following materials in parts by weight:

[0019] 11.75 parts of purified water;

[0020] 5 parts of Patrinia scabra extract;

[0021] 13 parts of Crape Myrtle Extract;

[0022] 8 parts of Dianthus caryophyllus extract;

[0023] 3 parts of witch hazel extract;

[0024] 1 part of Hedyotis diffusa extract;

[0025] Snowdrop extract 10 parts;

[0026] Bidens pilosa L. extract 8 parts;

[0027] 17 parts of Macleaya cordata extract;

[0028] Astaxanthin 13 parts;

[0029] 10 parts of hyaluronic acid;

[0030] 0.25 parts of trichlorohydroxydiphenyl ether.

[0031] Preferably, the purity of the Patrinia scabra extract, Crape Myrtle extract, Dianthus chinensis extract, Hamamelis virginiana extract, Oldenlandia diffusa extract, Snowdrop extract, Bidens pilosa extract, Macleaya cordata extract, astaxanthin, and hyaluronic acid is not less than 98%; the purity of the trichlorohydroxy diphenyl ether is not less than 99%.

[0032] Preferably, the Patrinia scabra extract is obtained by extracting the whole Patrinia scabra plant as raw material;

[0033] The crape myrtle extract is obtained by extracting the flowers, roots and leaves of crape myrtle as raw materials;

[0034] The dianthus extract is obtained by extracting the whole plant of dianthus as raw material;

[0035] The witch hazel extract is obtained by extracting the bark and branches of witch hazel as raw materials;

[0036] The Hedyotis diffusa extract is obtained by extracting the whole herb of Hedyotis diffusa as raw material;

[0037] The snowdrop extract is obtained by extracting the flower stems and leaves of snowdrop as raw materials;

[0038] The Bidens pilosa extract is obtained by extracting the whole Bidens pilosa plant as raw material;

[0039] The Macleaya cordata extract is obtained by extracting the whole plant with roots and fruits of Macleaya cordata as raw materials.

[0040] Preferably, the extraction method of each of the Patrinia scabra extract, the Crape Myrtle extract, the Dianthus chinensis extract, the Hamamelis jewelweed extract, the Oldenlandia diffusa extract, the Galanthus nivalis extract, the Bidens pilosa extract, and the Macleaya cordata extract is a carbon dioxide supercritical extraction method.

[0041] The female antibacterial gel described above can be used in the preparation of care products for inhibiting Staphylococcus aureus, Escherichia coli and Candida albicans.

[0042] Compared with the prior art, the invention has the following beneficial effects: the female antibacterial gel is composed of purified water, Herba Patriniae extract, Lagerstroemia extract, Dianthus extract, Hamamelis extract, Herba Hedyotis diffusae extract, Snowdrop extract, Bidens pilosa extract, Macleaya cordata extract, astaxanthin, hyaluronic acid and trichlorohydroxy diphenyl ether according to a certain weight ratio, wherein the Herba Patriniae extract and Herba Hedyotis diffusae extract have a preservative effect, the Lagerstroemia extract, Snowdrop extract, Bidens pilosa extract and Macleaya cordata extract have a toning effect, the Hamamelis extract makes the female antibacterial gel have a light fragrance, the Herba Hedyotis diffusae extract has a perfume-adjusting effect, astaxanthin can increase viscosity, hyaluronic acid has a lubricating effect and acts as a gel matrix, and the trichlorohydroxy diphenyl ether has a bacteriostatic effect, so that the female antibacterial gel has a suitable smell and color, and the gel viscosity and lubricity are relatively suitable, the use experience is good, and it can simultaneously inhibit Staphylococcus aureus, Escherichia coli and Candida albicans, has a good antibacterial effect, takes into account multiple indicators, and can improve its acceptance. DETAILED DESCRIPTION

[0043] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0044] In the following examples, the parts without specific conditions were carried out under conventional conditions or conditions recommended by the manufacturer, and the reagents or instruments used without indicating the manufacturer were all conventional products available from the market. In addition, 1 part in the following examples is 1 g.

[0045] Example 1: A female antibacterial gel

[0046] The female antibacterial gel is composed of the following materials in parts by weight: 10 parts of purified water; 4.5 parts of Patrinia extract; 11 parts of Crape Myrtle extract; 7 parts of Dianthus extract; 2.5 parts of Hamamelis extract; 0.8 parts of Hedyotis diffusa extract; 9 parts of Snowdrop extract; 7 parts of Bidens pilosa extract; 15 parts of Macleaya cordata extract; 11 parts of astaxanthin; 9 parts of hyaluronic acid; 0.2 parts of trichlorohydroxy diphenyl ether. Among them, the purity of Patrinia extract, Crape Myrtle extract, Dianthus extract, Hamamelis extract, Hedyotis diffusa extract, Snowdrop extract, Bidens pilosa extract, Macleaya cordata extract, astaxanthin, and hyaluronic acid in the female antibacterial gel is not less than 98%; the purity of trichlorohydroxy diphenyl ether is not less than 99%.

[0047] Some of the functions of various substances in the female antibacterial gel are as follows: the function of Patrinia scabra extract and Dianthus chinensis extract is preservative; the function of Crape Myrtle extract, Snowdrop extract, Bidens pilosa extract, and Macleaya cordata extract is color adjustment; the function of Hamamelis virginiana extract is to give the female antibacterial gel a light fragrance; the function of Oldenlandia diffusa extract is to adjust the fragrance; the function of astaxanthin is to increase the viscosity; the function of hyaluronic acid is lubrication and acts as a gel matrix; the function of trichlorohydroxydiphenyl ether is antibacterial.

[0048] The methods of obtaining some substances in the female antibacterial gel are as follows: the extract of Patrinia scabra is extracted from the whole plant of Patrinia scabra; the extract of Crape Myrtle is extracted from the flower, root and leaf of Crape Myrtle; the extract of Dianthus chinensis is extracted from the whole plant of Dianthus chinensis; the extract of Hamamelis virginiana is extracted from the bark and branches of Hamamelis virginiana; the extract of Hedyotis diffusa is extracted from the whole plant of Hedyotis diffusa; the extract of Snowdrop is extracted from the flower, stem and leaf of Snowdrop; the extract of Bidens pilosa is extracted from the whole plant of Bidens pilosa; the extract of Macleaya cordata is extracted from the whole plant with root and fruit of Macleaya cordata. The extraction methods of Patrinia scabra extract, Crape Myrtle extract, Dianthus chinensis extract, Hamamelis virginiana extract, Hedyotis diffusa extract, Snowdrop extract, Bidens pilosa extract and Macleaya cordata extract are respectively extracted by supercritical carbon dioxide extraction.

[0049] Taking the extraction of Patrinia scabra extract as an example, the process of using carbon dioxide supercritical extraction is as follows: the whole grass raw material of Patrinia scabra is dried and crushed, and then placed in an extractor and contacted with carbon dioxide supercritical fluid. The carbon dioxide supercritical fluid extracts the target compound from the raw material by dissolving it in contact with the raw material, and then the carbon dioxide supercritical fluid in which the target compound is dissolved is transferred to a separator, and the carbon dioxide is converted from a dissolved state to a gaseous state by reducing the pressure or changing the temperature, so that the extracted target compound can be separated, and the separated target compound can be recovered by condensation or other methods, and the carbon dioxide can be reused. The extraction method of other extracts in the female antibacterial gel refers to the extraction method of Patrinia scabra extract, and will not be described one by one here. In addition, according to the properties of each substance, common extraction methods such as solvent extraction and ultrasonic extraction can also be adaptively selected.

[0050] Purified water, astaxanthin, hyaluronic acid, and trichlorohydroxydiphenyl ether can all be purchased from the market. The CAS number of hyaluronic acid is 9004-61-9, and the CAS number of trichlorohydroxydiphenyl ether is 3380-34-5.

[0051] In addition, in some embodiments, Patrinia scabra extract, Crape Myrtle extract, Dianthus chinensis extract, Hamamelis virginiana extract, Oldenlandia diffusa extract, Galanthus nivalis extract, Bidens pilosa extract, and Macleaya cordata extract can also be purchased from the market.

[0052] The female antibacterial gel is prepared by fully mixing and blending the materials in parts by weight.

[0053] The female antibacterial gel is composed of purified water, Herba Patriniae extract, Lagerstroemia extract, Dianthus extract, Hamamelis extract, Herba Hedyotis diffusae extract, Snowdrop extract, Bidens pilosa extract, Macleaya cordata extract, astaxanthin, hyaluronic acid, and trichlorohydroxydiphenyl ether in a certain weight ratio. The Herba Patriniae extract and Dianthus extract have a preservative effect, the Lagerstroemia extract, Snowdrop extract, Bidens pilosa extract, and Macleaya cordata extract have a toning effect, the Hamamelis extract makes the female antibacterial gel have a light fragrance, the Herba Hedyotis diffusae extract has a perfume-adjusting effect, the astaxanthin can increase the viscosity, the hyaluronic acid has a lubricating effect and acts as a gel matrix, and the trichlorohydroxydiphenyl ether has an antibacterial effect, so that the female antibacterial gel has a suitable smell and color, and the gel viscosity and lubricity are relatively suitable, the use experience is good, and it can simultaneously inhibit Staphylococcus aureus, Escherichia coli, and Candida albicans, and has a good antibacterial effect. It takes into account multiple indicators and can improve its acceptance.

[0054] Example 2: A female antibacterial gel

[0055] The female antibacterial gel is composed of the following substances in parts by weight: 11.75 parts of purified water; 5 parts of Patrinia scabra extract; 13 parts of Crape Myrtle extract; 8 parts of Dianthus chinensis extract; 3 parts of Hamamelis virginiana extract; 1 part of Oldenlandia diffusa extract; 10 parts of Snowdrop extract; 8 parts of Bidens pilosa extract; 17 parts of Macleaya cordata extract; 13 parts of astaxanthin; 10 parts of hyaluronic acid; and 0.25 parts of trichlorohydroxydiphenyl ether.

[0056] The acquisition and preparation methods of the various substances in the female antibacterial gel in this embodiment can be referred to Example 1, and will not be repeated here.

[0057] Example 3: A female antibacterial gel

[0058] The female antibacterial gel is composed of the following materials in parts by weight: 13 parts of purified water; 6 parts of Patrinia scabra extract; 14 parts of Crape Myrtle extract; 9 parts of Dianthus chinensis extract; 4 parts of Hamamelis virginiana extract; 1.3 parts of Oldenlandia diffusa extract; 12 parts of Snowdrop extract; 9 parts of Bidens pilosa extract; 19 parts of Macleaya cordata extract; 15 parts of astaxanthin; 11 parts of hyaluronic acid; and 0.3 parts of trichlorohydroxydiphenyl ether.

[0059] The acquisition and preparation methods of the various substances in the female antibacterial gel in this embodiment can be referred to Example 1, and will not be repeated here.

[0060] The female antibacterial gel in the above embodiments can be used to prepare a care product that can inhibit Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0061] In order to detect the relevant indicators of the female antibacterial gel, the following relevant tests were conducted on the female antibacterial gel:

[0062] Multiple vaginal mucosal irritation test

[0063] The purpose of the multiple vaginal mucosal irritation test is to test the irritation of the female antibacterial gel to the vaginal mucosa. This test was commissioned by Ingel Testing Technology Service (Shanghai) Co., Ltd. The specific test process and conclusions are as follows:

[0064] 1. Equipment and Animals

[0065] 1. Test samples: Female antibacterial gel (production batch number: 20220605; maximum application concentration: original sample), this sample is a female antibacterial gel with the same weight composition as that in the previous Example 2.

[0066] 2. Animals: 6 Japanese white rabbits, female, weighing 2.0kg to 2.5kg, provided by Beijing Changyang Xishan Breeding Farm, ordinary grade animals, production license number SCXK (Beijing) 2021-0008, quality certificate number 110329221100049623. Feed was provided by Sibeifu (Beijing) Biotechnology Co., Ltd., production license number SCXK (Beijing) 2019-0010, quality certificate number 1103242200082301, animal room temperature 19℃~26℃, relative humidity 40%~70%. 12h lighting, 12h dark. Animals were free to eat and drink water.

[0067] 3. Reagents and instruments: Eosin (Batch No.: 1219A0219), Hematoxylin staining solution (Batch No.: L05N11G1300606), biological microscope (Model: Olympus CX41, Number: DL001), advanced intelligent dehydrator (Model: Leica ASP200S, Number: DL002), paraffin embedding machine (Model: Leica HistoCore Arcadia, Number: DL003), rotary slicer (Model: Leica RM2235, Number: DL007), electronic balance (Model: PL6001E, Number: DL013).

[0068] 2. Methods

[0069] 1. Test basis: Item 2.3.5 of Technical Specifications for Disinfection (2002 edition).

[0070] 2. Preparation of test samples: Use the original test samples.

[0071] 3. Poisoning method: Connect a blunt-tipped hose of about 8 cm in length to a 2 ml syringe. Fill the syringe and catheter with the test sample and set aside. Fix the animal in a supine position, exposing the perineum and vaginal opening. Wet the catheter with the original test sample and gently insert it into the vagina (4 cm to 5 cm), and slowly inject 2 mL of the original test sample with a syringe, then remove the catheter to complete the poisoning. Repeat the poisoning every 24 hours for 5 consecutive days. The animals in the control group were treated with normal saline in the same way.

[0072] 4. Pathological preparation and observation: 24 hours after the last exposure, the animals were killed by gas embolism, and the intact vagina was dissected and observed with the naked eye for pathological changes such as congestion and edema for reference when sampling. Then the vaginal specimen was fixed in 10% formalin solution for more than 24 hours, and tissues from the front, middle and back ends of the vagina were selected for pathological paraffin preparation, HE staining, and pathological light microscopy examination.

[0073] 5. Evaluation indicators: The scoring standards and grading of stimulation intensity refer to Table 2-16 and Table 2-17 in 2.3.5 “Vaginal mucosal irritation test” of the Technical Specifications for Disinfection (2002 edition).

[0074] 3. Results

[0075] 24 hours after the animals were given the test samples or saline, no obvious abnormalities were observed in the clinical observation of the animals, and no obvious abnormalities were found during the gross examination of the dissected samples. Microscopic observation showed that the front and rear ends of the vagina of animal No. 1001 in the control group had very few leukocyte infiltrations, and epithelial tissue cell degeneration or flattening in the middle end; the middle end of the vagina of animal No. 1002 had very few leukocyte infiltrations, and epithelial tissue cell degeneration or flattening in the rear end; the front end of the vagina of animal No. 1003 had epithelial tissue cell degeneration or flattening and very few leukocyte infiltrations, and very few leukocyte infiltrations in the rear end. In the experimental group, the front and rear ends of the vagina of animal No. 2004 showed epithelial cell degeneration or flattening and very few leukocyte infiltration, and very few leukocyte infiltration in the middle end; the front and rear ends of the vagina of animal No. 2005 showed epithelial cell degeneration or flattening, and very few leukocyte infiltration in the middle end; the front end of the vagina of animal No. 2006 showed epithelial cell degeneration or flattening and very few leukocyte infiltration, very few leukocyte infiltration in the middle end, and epithelial cell degeneration or flattening in the rear end. Vaginal mucosal irritation reaction score (see Table 1).

[0076] Table 1 Japanese big-eared white rabbit vaginal mucosal irritation test scoring results

[0077]

[0078] Note: The reaction score of each part is the sum of the 4 reaction scores. Irritation index = average score of the experimental group - average score of the control group.

[0079] IV. Conclusion

[0080] After testing, The female antibacterial gel was used in the Japanese white rabbit multiple vaginal mucosal irritation test using the original sample, and the irritation index was 0.55 (<1), and the intensity of the irritation reaction was none. It met the requirements of the "Technical Specifications for Disinfection" (2002 edition).

[0081] Stability test of trichlorohydroxydiphenyl ether

[0082] The stability test of trichlorohydroxy diphenyl ether is designed to test the stability of trichlorohydroxy diphenyl ether in the female antibacterial gel to ensure its effectiveness during the stable period. This test was commissioned by Ingel Testing Technology Service (Shanghai) Co., Ltd. The specific test process and conclusions are as follows:

[0083] 1. Equipment

[0084] 1. Test samples: Female antibacterial gel. This sample is a female antibacterial gel with the same weight composition as that in the previous Example 2.

[0085] 2. BSA124S analytical balance (Sartorius), sensitivity 0.1 mg

[0086] 3.1260Ifinity Agilent HPLC, accuracy +1nm

[0087] 2. Methods

[0088] 1. Test basis: "Technical Specifications for Disinfection" (2002 Edition) 2.2.3.2.1, Appendix C of GB / T27947-2020

[0089] 2. Detection environment temperature 21.1℃, relative humidity 41.8%

[0090] 3. Results

[0091] After the sample was placed in an environment with a temperature of 54°C for 14 days, the content of trichlorohydroxydiphenyl ether decreased by 4.5%, and the storage period can be determined as 1 year. The results are listed in Table 2.

[0092] Table 2 Stability test results of trichlorohydroxydiphenyl ether before and after storage

[0093]

[0094] IV. Conclusion

[0095] After the sample was placed in an environment with a temperature of 54°C for 14 days, the content of trichlorohydroxydiphenyl ether decreased by 4.5%, and the storage period can be determined as 1 year.

[0096] Dissolution inhibition test (Escherichia coli, Staphylococcus aureus, Candida albicans)

[0097] The dissolution antibacterial test (Escherichia coli, Staphylococcus aureus, Candida albicans) is designed to detect the antibacterial effect of the female antibacterial gel on Escherichia coli, Staphylococcus aureus, and Candida albicans. This test was commissioned by Ingel Testing Technology Service (Shanghai) Co., Ltd. The specific test process and conclusions are as follows:

[0098] 1. Equipment

[0099] 1. Test strains: Escherichia coli ATCC 25922, 4th generation; Staphylococcus aureus ATCC 6538, 4th generation; Candida albicans ATCC 10231, 4th generation.

[0100] 2. Test samples: Female antibacterial gel. This sample is a female antibacterial gel with the same weight composition as that in the previous Example 2.

[0101] 2. Methods

[0102] 1.Testing basis: Appendix C4 of GB15979-2002 "Sanitary Standards for Disposable Sanitary Products"

[0103] 2. The test environment temperature is 21℃ and the humidity is 52%

[0104] 3. Test conditions: The test was repeated 3 times.

[0105] 3. Results

[0106] 1. Dissolution inhibition test (Escherichia coli)

[0107] After 3 repeated tests, the The inhibition rates of the female antibacterial gel on Escherichia coli after 2 minutes, 5 minutes, 10 minutes and 20 minutes are shown in Table 3.

[0108] Table 3 Antibacterial effect of female antibacterial gel on Escherichia coli

[0109]

[0110] 2. Dissolution inhibition test (Staphylococcus aureus)

[0111] After 3 repeated tests, the The inhibition rates of the female antibacterial gel on Staphylococcus aureus after 2 minutes, 5 minutes, 10 minutes and 20 minutes are shown in Table 4.

[0112] Table 4 Antibacterial effect of female antibacterial gel on Staphylococcus aureus

[0113]

[0114] 3. Dissolution inhibition test (Candida albicans)

[0115] After 3 repeated tests, the The inhibition rates of the female antibacterial gel on Candida albicans after 2 minutes, 5 minutes, 10 minutes and 20 minutes of action are shown in Table 5.

[0116] Table 5 Antibacterial effect of female antibacterial gel on Candida albicans

[0117]

[0118] IV. Conclusion

[0119] Antibacterial performance test: After three repeated tests, the results showed that the sample had antibacterial effects on Escherichia coli, Staphylococcus aureus and Candida albicans after 2 minutes of exposure, which met the requirements of GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products".

[0120] Total bacterial colonies, coliform bacteria, Pseudomonas aeruginosa, Staphylococcus aureus, hemolytic streptococci, total fungal colonies Number Test

[0121] This test project is designed to detect whether the microbial indicators in the female antibacterial gel meet the standards. This test was commissioned by Ingel Testing Technology Services (Shanghai) Co., Ltd. The specific test process and conclusions are as follows:

[0122] 1. Equipment

[0123] 1. Test samples: Female antibacterial gel. This sample is a female antibacterial gel with the same weight composition as that in the previous Example 2.

[0124] 2. Methods

[0125] 1. Test basis: Appendix B of GB 15979-2002 "Sanitary Standards for Disposable Sanitary Products"

[0126] 2. Test environment temperature 24.8℃, relative humidity 52%

[0127] 3. Results

[0128] Table 6 Microbial index results

[0129] project result Total number of bacterium colonies (CFU / g) <4 Coliform bacteria Not detected Pseudomonas aeruginosa Not detected Staphylococcus aureus Not detected Hemolytic Streptococcus Not detected Total fungal colony count (CFU / g) <4

[0130] IV. Conclusion

[0131] The microbiological indicators of the sample all meet the requirements of GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products".

[0132] Lead, arsenic, mercury heavy metal content detection

[0133] 1. Equipment

[0134] 1. Test samples: Female antibacterial gel. This sample is a female antibacterial gel with the same weight composition as that in the previous Example 2.

[0135] 2. Instruments and equipment: electronic balance, model BSA124S; microwave digestion instrument, model TOPEX; inductively coupled plasma mass spectrometer (ICP-MS), model NexIon 350X

[0136] 3. Standard solution concentration: Mercury standard solution (1000mg); Arsenic standard solution (1000mg); Lead standard solution (1000mgL)

[0137] 2. Methods

[0138] 1. Testing basis: "Technical Specifications for Safety of Cosmetics" (2015 edition)

[0139] 2. Detection environment temperature 22.6, relative humidity 42%

[0140] 3. Results

[0141] Table 7 Results of lead, arsenic and mercury determination in female antibacterial gel

[0142]

[0143]

[0144] IV. Conclusion

[0145] The lead content of the sample was undetectable (<0.09mg / kg), the arsenic content was undetectable (<0.0033mg / kg), and the mercury content was undetectable (<0.0033mg / kg), which met the requirements.

[0146] It should be noted that, although embodiments of the present invention have been shown and described herein, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A female antibacterial gel, characterized in that: The female antibacterial gel is composed of the following materials in parts by weight: 10-13 parts of purified water; 4.5-6 parts of Patrinia scabra extract; 11-14 parts of crape myrtle extract; 7-9 parts of dianthus extract; 2.5-4 parts of witch hazel extract; 0.8-1.3 parts of Hedyotis diffusa extract; 9-12 parts of snowdrop extract; Bidens pilosa L. extract 7-9 parts; 15-19 parts of Macleaya cordata extract; Astaxanthin 11-15 parts; 9-11 parts of hyaluronic acid; 0.2-0.3 parts of trichlorohydroxydiphenyl ether.

2. The female antibacterial gel according to claim 1, characterized in that: The female antibacterial gel is composed of the following materials in parts by weight: 11.75 parts of purified water; 5 parts of Patrinia scabra extract; 13 parts of Crape Myrtle Extract; 8 parts of Dianthus caryophyllus extract; 3 parts of witch hazel extract; 1 part of Hedyotis diffusa extract; Snowdrop extract 10 parts; Bidens pilosa L. extract 8 parts; 17 parts of Macleaya cordata extract; Astaxanthin 13 parts; 10 parts of hyaluronic acid; 0.25 parts of trichlorohydroxydiphenyl ether.

3. The female antibacterial gel according to claim 1, characterized in that: The purity of the Patrinia scabra extract, Crape Myrtle extract, Dianthus chinensis extract, Hamamelis virginiana extract, Oldenlandia diffusa extract, Snowdrop extract, Bidens pilosa extract, Macleaya cordata extract, astaxanthin, and hyaluronic acid is not less than 98%; the purity of the trichlorohydroxy diphenyl ether is not less than 99%.

4. The female antibacterial gel according to claim 1, characterized in that: The Patrinia scabra extract is obtained by extracting the whole Patrinia scabra plant as raw material; The crape myrtle extract is obtained by extracting the flowers, roots and leaves of crape myrtle as raw materials; The dianthus extract is obtained by extracting the whole plant of dianthus as raw material; The witch hazel extract is obtained by extracting the bark and branches of witch hazel as raw materials; The Hedyotis diffusa extract is obtained by extracting the whole herb of Hedyotis diffusa as raw material; The snowdrop extract is obtained by extracting the flower stems and leaves of snowdrop as raw materials; The Bidens pilosa extract is obtained by extracting the whole Bidens pilosa plant as raw material; The Macleaya cordata extract is obtained by extracting the whole plant with roots and fruits of Macleaya cordata as raw materials.

5. The female antibacterial gel according to claim 4, characterized in that: The extraction methods of the Patrinia scabra extract, the Crape Myrtle extract, the Dianthus chinensis extract, the Hamamelis virginiana extract, the Oldenlandia diffusa extract, the Snowdrop extract, the Bidens pilosa extract, and the Macleaya cordata extract are respectively carried out by supercritical carbon dioxide extraction.

6. Use of the female antibacterial gel according to any one of claims 1 to 5 in the preparation of a care product for inhibiting Staphylococcus aureus, Escherichia coli and Candida albicans.

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