Oil-control and anti-dandruff composition containing scutellaria baicalensis root extract as well as preparation method and application of oil-control and anti-dandruff composition

Abstract

The invention relates to the technical field of cosmetics, and discloses an oil-controlling and anti-dandruff composition containing a scutellaria baicalensis root extract and a preparation method and application thereof.The composition is prepared from, by mass, 0.05-1 part of the scutellaria baicalensis root extract, 0.1-1 part of piroctone olamine salt and 0.03-1.5 parts of an antioxidant, and the main components of the composition are the scutellaria baicalensis root extract and the piroctone olamine salt, according to the composition, the grease inhibition effect of the composition can be remarkably improved while the low dosage of the piroctone olamine salt is reduced, and the composition also has a remarkable inhibition effect on malassezia chaff and staphylococcus aureus while the low dosage of the piroctone olamine salt is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to an oil-controlling and anti-dandruff composition containing a scutellaria baicalensis root extract, a preparation method and an application thereof. Background Art

[0002] Dandruff is a common disease of the scalp, also known as "pityriasis capitis" in medicine. The clinical manifestations are excessive fine gray-white dry or slightly greasy bran-like flakes on the scalp or hair, which may be accompanied by itching, and the incidence rate is extremely high among the population. The causes of dandruff are generally related to three factors, namely oil, microorganisms and metabolism. When the sebaceous glands of a healthy scalp are relatively active, oil secretion increases, the scalp will appear greasy, the skin microorganisms (Malassezia furfur, Staphylococcus, etc.) increase, the sebaceous glands expand and even form cysts. When the scalp colony is unbalanced, Malassezia furfur multiplies in large numbers on the scalp, causing excessive proliferation of the scalp stratum corneum, thereby promoting abnormal shedding of stratum corneum cells in the form of white or gray scales, that is, forming dandruff. Therefore, excessive secretion of sebaceous glands is a prerequisite for the occurrence of dandruff, and oil control is also the first step to solve dandruff, and inhibiting Malassezia furfur is the second step.

[0003] There are 5 kinds of anti-dandruff agents in the cosmetic safety technical specification, namely salicylic acid, zinc pyrithione (ZPT), ketoconazole, climbazole and piroctone olamine (OCT). Currently, zinc pyrithione (ZPT) and piroctone olamine (OCT) are more commonly used, and piroctone olamine has lower toxicity, excellent solubility and compounding properties, and lower irritation compared with other anti-dandruff agents. As disclosed in publication number CN114191322A, a kind of anti-dandruff oil-control composition and its preparation method and application, the addition of plant extracts Sophora flavescens extract and allantoin in the technical solution can solve the impact of ultraviolet irradiation on the anti-dandruff function of piroctone olamine, thereby improving the beneficial effect of its composition on the anti-dandruff function. Another example is a novel anti-dandruff composition and preparation method disclosed in publication number CN109106670A. The plant extracts and alcohols used in the technical solution can improve the penetration of piroctone olamine salt, enhance the attack power of piroctone olamine salt molecules on Malassezia furfur cells, and promote the formation of mixed absorption films by alcohol moisturizers. In the prior art, the usual usage of piroctone olamine salt accounts for a high proportion, resulting in a significant increase in the production cost of its products, and high-content piroctone olamine salt is irritating to the skin, and the user experience is poor. Summary of the invention

[0004] In order to overcome the problem of high cost and high irritation of piroctone olamine salt anti-dandruff products in the prior art, the present invention provides an oil-control anti-dandruff composition containing scutellaria root extract, a preparation method and application. The main components of the composition are scutellaria root extract and piroctone olamine salt. The composition can significantly improve the oil inhibition effect of the composition while reducing the low dosage of piroctone olamine salt. The composition can significantly inhibit Malassezia furfur and Staphylococcus aureus while reducing the low dosage of piroctone olamine salt.

[0005] The specific technical scheme of the present invention is: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.05-1 part of Scutellaria baicalensis root extract, 0.1 to 1.0 parts of piroctone olamine salt, Antioxidant 0.03 to 1.5 parts.

[0006] The baicalin content in the scutellaria root extract is ≥80%.

[0007] The antioxidant is one or both of sodium pyrosulfite and sodium sulfite.

[0008] The invention provides an oil-controlling and anti-dandruff composition containing a scutellaria root extract. The main components of the composition are the scutellaria root extract and piroctone olamine salt. The composition has excellent oil-controlling and anti-dandruff effects. The composition can reduce the dosage of the piroctone olamine salt and also has a significant inhibitory effect on Malassezia furfur and Staphylococcus aureus.

[0009] In the prior art, the research on the antidandruff effect of piroctone olamine salt mainly focuses on the inhibitory effect of Malassezia furfur. Therefore, in order to ensure the antibacterial effect of piroctone olamine salt, the amount of piroctone olamine salt added in the product is relatively high. However, due to the high cost of piroctone olamine salt, in order to balance the product cost and efficacy, the antibacterial and antidandruff effect of the actual piroctone olamine salt product is relatively poor. In addition, excessive use of piroctone olamine salt will also lead to enhanced irritation of the product. Therefore, the present invention provides an oil-controlling and anti-dandruff composition containing scutellaria root extract in view of the above-mentioned problems. The present application finds that the composition formed by compounding scutellaria root extract and piroctone olamine salt has a significantly increased ability to inhibit oil and fat, which is significantly higher than the technical solution using only piroctone olamine salt. In addition, the composition formed by compounding scutellaria root extract and low amount of piroctone olamine salt has a significantly higher ability to inhibit oil and fat than the technical solution using high amount of piroctone olamine salt alone.

[0010] In addition, the present invention also finds that the composition of scutellaria root extract and piroctone olamine salt has an extremely significant inhibitory effect on Malassezia furfur and Staphylococcus aureus, and when a low amount of piroctone olamine salt and the composition of scutellaria root extract are used, the inhibitory effect on Malassezia furfur and Staphylococcus aureus is still extremely significant. The inhibitory effect of the composition of scutellaria root extract and piroctone olamine salt on Malassezia furfur and Staphylococcus aureus is significantly higher than the technical solution of using piroctone olamine salt alone or using scutellaria root extract alone.

[0011] A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing scutellaria root extract comprises the following steps: adding piroctone olamine salt to hot water to adjust the initial pH, stirring evenly, cooling and adding scutellaria root extract and antioxidants and adjusting the final pH to prepare the oil-controlling and anti-dandruff composition containing scutellaria root extract.

[0012] Preferably, the temperature of the hot water is 70-80°C, and the temperature of the cooling is 35-40°C.

[0013] Preferably, the initial pH is 8.0-9.5, and the final pH is 9.0.

[0014] An application of the above-mentioned oil-controlling and anti-dandruff composition containing scutellaria root extract in cosmetics comprises the following steps: mixing phase A, phase B and phase C to prepare cosmetics, wherein phase B is the oil-controlling and anti-dandruff composition containing scutellaria root extract.

[0015] Preferably, the added amount of the phase B is 0.3-2.3%.

[0016] Preferably, the added amount of the phase B is 0.4-1.3%.

[0017] Preferably, the phase A comprises one or more of water, sodium laureth sulfate, cocamidopropyl betaine, sodium methyl cocoyl taurate and ethylene glycol distearate. Preferably, the C phase includes ethylhexylglycerin, phenoxyethanol, carbomer and a pH adjuster. Preferably, the pH regulator is one or more of sodium hydroxide, citric acid, arginine and triethanolamine.

[0018] Compared with the prior art, this application has the following technical effects: The present invention provides an oil-controlling and anti-dandruff composition containing scutellaria root extract, a preparation method and an application thereof. The main components of the composition are scutellaria root extract and piroctone olamine salt. The composition can significantly improve the oil inhibition effect of the composition while reducing the low dosage of piroctone olamine salt. The composition can significantly inhibit Malassezia furfur and Staphylococcus aureus while reducing the low dosage of piroctone olamine salt. DETAILED DESCRIPTION

[0019] The present invention will be further described below in conjunction with the embodiments.

[0020] Embodiment 1: The invention discloses an oil-controlling and anti-dandruff composition containing a scutellaria root extract, which comprises, by weight: 0.05 parts of a scutellaria root extract, 0.2 parts of piroctone olamine salt, and 0.1 parts of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥80%, and the antioxidant is 0.1 parts of sodium pyrosulfite.

[0021] A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0022] Embodiment 2: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.05 parts of a scutellaria root extract, 0.45 parts of piroctone olamine salt, 0.1 parts of an antioxidant, the baicalin content in the scutellaria root extract being ≥ 80%, and the antioxidant being 0.5 parts of sodium pyrosulfite and 0.5 parts of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0023] Embodiment 3: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.05 parts of a scutellaria root extract, 0.7 parts of piroctone olamine salt, 0.1 parts of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥ 80%, and the antioxidant is 0.1 parts of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0024] Embodiment 4: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract, 0.2 part of piroctone olamine salt, 0.12 part of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥ 80%, and the antioxidant is 0.12 part of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0025] Embodiment 5: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract, 0.45 part of piroctone olamine salt, 0.12 part of an antioxidant, the baicalin content in the scutellaria root extract being ≥ 80%, and the antioxidant being 0.06 part of sodium pyrosulfite and 0.06 part of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0026] Embodiment 6: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract, 0.7 part of piroctone olamine salt, 0.12 part of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥ 80%, and the antioxidant is 0.12 part of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0027] Embodiment 7: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.15 parts of a scutellaria root extract, 0.2 parts of piroctone olamine salt, 0.3 parts of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥ 80%, and the antioxidant is 0.3 parts of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0028] Embodiment 8: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.15 parts of a scutellaria root extract, 0.45 parts of piroctone olamine salt, 0.3 parts of an antioxidant, the baicalin content in the scutellaria root extract being ≥ 80%, and the antioxidant being 0.15 parts of sodium pyrosulfite and 0.15 parts of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0029] Embodiment 9: An oil-controlling and anti-dandruff composition containing a scutellaria root extract, comprising, by weight: 0.15 parts of a scutellaria root extract, 0.7 parts of piroctone olamine salt, 0.3 parts of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥ 80%, and the antioxidant is 0.15 parts of sodium sulfite; A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone ethanolamine salt is added into deionized water at 70-80° C., a pH adjuster is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH adjuster is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition.

[0030] Embodiment 10: The invention discloses an oil-controlling and anti-dandruff composition containing a scutellaria root extract, which comprises, by weight: 0.1 part of a scutellaria root extract, 0.45 part of piroctone olamine salt, and 0.1 part of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥80%, and the antioxidant is 0.1 part of sodium pyrosulfite.

[0031] A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone olamine salt is added into deionized water at 70-80° C., a pH regulator is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., a pH regulator (sodium hydroxide) is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition; The invention discloses an application of the oil-control and anti-dandruff composition containing scutellaria root extract in shampoo, comprising the following steps: mixing phase A raw materials (10 wt% sodium laureth sulfate, 7 wt% cocamidopropyl betaine, 5 wt% sodium methyl cocoyl taurate, 1.1 wt% ethylene glycol distearate and water), heating to 80°C, stirring to completely dissolve, cooling to 40°C after dissolution, adding the remaining phase B raw materials (0.65 wt% oil-control and anti-dandruff composition containing scutellaria root extract) and phase C raw materials (0.2 wt% ethylhexylglycerin, 0.5 wt% phenoxyethanol and 0.5 wt% carbomer, and adjusting the pH of the final product to 6 using citric acid), stirring until completely dissolved to prepare a transparent oil-control and anti-dandruff shampoo.

[0032] Embodiment 11: The invention discloses an oil-controlling and anti-dandruff composition containing a scutellaria root extract, which comprises, by weight: 0.1 part of a scutellaria root extract, 0.45 part of piroctone olamine salt, and 0.1 part of an antioxidant, wherein the baicalin content in the scutellaria root extract is ≥80%, and the antioxidant is 0.1 part of sodium pyrosulfite.

[0033] A method for preparing the above-mentioned oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract comprises the following steps: Piroctone olamine salt is added into deionized water at 70-80° C., a pH regulator is added to adjust the initial pH to 8.0-9.5, the mixture is stirred evenly and then cooled to 35-40° C., and a pH regulator (arginine) is added to adjust the final pH to 9.0 to obtain an oil-controlling and anti-dandruff composition; The invention discloses an application of the oil-control and anti-dandruff composition containing scutellaria root extract in shampoo, comprising the following steps: mixing phase A raw materials (10 wt% sodium laureth sulfate, 7 wt% cocamidopropyl betaine, 5 wt% sodium methyl cocoyl taurate, 1.1 wt% ethylene glycol distearate and water), heating to 80°C, stirring to completely dissolve, cooling to 40°C after dissolution, adding the remaining phase B raw materials (0.65 wt% oil-control and anti-dandruff composition containing scutellaria root extract) and phase C raw materials (0.2 wt% ethylhexylglycerin, 0.5 wt% phenoxyethanol and 0.5 wt% carbomer, and adjusting the pH of the final product to 6 using citric acid), stirring until completely dissolved to prepare an opaque oil-control and anti-dandruff shampoo.

[0034] Comparative Example 1: The invention discloses an oil-controlling and anti-dandruff composition containing scutellaria root extract, which comprises, by weight: 0.1 part of scutellaria root extract, 0.1 part of antioxidant, the baicalin content in the scutellaria root extract being ≥80%, and 0.1 part of sodium pyrosulfite as the antioxidant.

[0035] Comparative Example 2: The invention discloses an oil-controlling and anti-dandruff composition containing scutellaria root extract, which comprises, by weight: 0.1 part of scutellaria root extract, 0.1 part of antioxidant, the baicalin content in the scutellaria root extract being ≥80%, and 0.1 part of sodium sulfite as the antioxidant.

[0036] Comparative Example 3: The invention discloses an oil-controlling and anti-dandruff composition containing scutellaria root extract, which comprises, by weight: 0.1 part of scutellaria root extract, 0.1 part of antioxidant, the baicalin content in the scutellaria root extract being ≥80%, and the antioxidant being 0.05 part of sodium pyrosulfite and 0.05 part of sodium sulfite.

[0037] Comparative Example 4: An oil-controlling and anti-dandruff composition containing scutellaria root extract comprises, by weight: 0.1 part of scutellaria root extract, wherein the content of baicalin in the scutellaria root extract is ≥ 80%.

[0038] Comparative Example 5: An oil-controlling and anti-dandruff composition containing a scutellaria root extract comprises, by weight: 0.45 parts of piroctone olamine salt and 0.1 parts of an antioxidant, wherein the antioxidant is 0.1 parts of sodium pyrosulfite.

[0039] Comparative Example 6: An oil-controlling and anti-dandruff composition containing a scutellaria root extract comprises, by mass: 0.45 parts of piroctone ethanolamine salt.

[0040] Comparative Example 7: An oil-controlling and anti-dandruff composition containing a scutellaria root extract comprises, by mass: 1 part of piroctone ethanolamine salt.

[0041] Comparative Example 8: An oil-controlling and anti-dandruff composition containing a scutellaria root extract comprises, by mass, 1 part of piroctone olamine salt and 0.5 part of a Platycladus orientalis leaf extract.

[0042] Comparative Example 9: Compared with Example 10, in Comparative Example 9, no oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract was added.

[0043] Comparative Example 10: Compared with Example 10, the oil-controlling and anti-dandruff composition added in Comparative Example 10 does not contain sodium metabisulfite.

[0044] Comparative Example 11: Compared with Example 10, the oil-controlling and anti-dandruff composition in Comparative Example 11 is 1 part of piroctone ethanolamine salt.

[0045] Comparative Example 12: Compared with Example 10, the oil-controlling and anti-dandruff composition in Comparative Example 12 contains 1 part of piroctone olamine salt and 0.5 part of Platycladus orientalis leaf extract, and no antioxidant is added.

[0046] Comparative Example 13: Compared with Example 10, the pH of the composition in Comparative Example 13 was not adjusted.

[0047] Comparative Example 14: Compared with Example 11, in Comparative Example 14, no oil-controlling and anti-dandruff composition containing Scutellaria baicalensis root extract was added.

[0048] Comparative Example 15: Compared with Example 11, the oil-controlling and anti-dandruff composition added in Comparative Example 15 does not contain sodium metabisulfite.

[0049] Comparative Example 16: Compared with Example 11, the oil-controlling and anti-dandruff composition in Comparative Example 16 is 1 part of piroctone ethanolamine salt.

[0050] Comparative Example 17: Compared with Example 11, the oil-controlling and anti-dandruff composition in Comparative Example 17 contains 1 part of piroctone olamine salt and 0.5 part of Platycladus orientalis leaf extract, and no antioxidant is added.

[0051] Comparative Example 18: Compared with Example 11, the pH of the composition in Comparative Example 18 was not adjusted.

[0052] Test example 1: The compositions prepared in the above Examples 1 to 9 and Comparative Examples 1 to 8 were tested, and the test items included: relative oil content and oil inhibition rate of SZ95 cells; The sebaceous gland cell SZ95 strain suspension extracted from the tissue sample was inoculated into a 96-well cell culture plate and cultured for 18 to 24 hours until the cells reached 80% confluence. The original culture medium in the well was discarded, and 50 μL of the sample solution was added to each well in turn; during the experiment, a blank control (group B), a model (group M), and a positive control (PC) were set up, the positive control was isotretinoin, the experimental test groups were Examples 1 to 9 and Comparative Examples 1 to 6, and the sample concentration was 10 -4 %; After adding the sample, add 50 μL of cell culture medium to the model group, and add 50 μL of cell culture medium containing linoleic acid to the other groups; After adding the sample, place the culture plate in an incubator and culture for (24±1) hours. After the culture is completed, wash once with PBS, add 100 μL of Nile red to each well, react at 37°C in the dark for 20 minutes, and detect the fluorescence intensity at Ex / Em=485nm / 565nm; In the formula, MEI 样品 is the mean fluorescence intensity of the sample group, MEI Bis the mean fluorescence intensity and MEI of group B M is the mean fluorescence intensity of group M. The test results are shown in Table 1; Table 1 Immediate solubility, 48-hour stability and antioxidant properties Relative lipid content of SZ95 cells (%) Oil inhibition rate (%) Blank control (Group B) 62.25 / Model (Group M) 100 / Positive control (PC group) 83.13 16.87 Example 1 81.96 17.24 Example 2 80.72 19.8 Example 3 78.41 21.32 Example 4 81.45 17.19 Example 5 78.76 19.86 Example 6 77.20 22.57 Example 7 80.65 20.43 Example 8 75.67 24.69 Example 9 70.41 29.7 Comparative Example 1 95.20 3.84 Comparative Example 2 94.97 4.86 Comparative Example 3 95.87 3.46 Comparative Example 4 96.63 2.57 Comparative Example 5 87.56 11.98 Comparative Example 6 86.42 13.25 Comparative Example 7 77.36 15.28 Comparative Example 8 77 18.5 As shown in Table 1, compared with the blank control group, the neutral oil content of the model group increased significantly, indicating that the stimulation was effective; compared with the model group, the neutral oil content of the positive control group decreased significantly, indicating that the modeling was successful; after structural analysis, it was found that the oil inhibition rate of Examples 1 to 9 was 17.19-29.7%, the oil inhibition rate of Comparative Examples 1 to 4 was only 2.57-4.86%, and the oil inhibition rate in Comparative Examples 5 to 6 was only 11.98-13.25%. The above results show that the composition provided by the present invention has an excellent oil inhibition effect. In addition, when the amount of piroctone olamine salt in Comparative Examples 7 and 8 was increased to 1%, the oil inhibition rate was increased to 15.28-18.5%, and its effect was equivalent to the composition composed of 0.2% piroctone olamine salt and 0.05% scutellariae root extract of the present invention. The above results show that the composition of the present invention can significantly enhance the ability of the composition to inhibit cell oil while reducing the amount of piroctone olamine salt.

[0053] Test example 2: The compositions prepared in Examples 1 to 9, Comparative Examples 1 and 5, and the shampoos prepared in Examples 10, 11, 9, and 14 were subjected to antibacterial experimental tests. The antibacterial experimental tests refer to "WS / T650-2019 Antibacterial and Antibacterial Effect Evaluation Method 5.1.1 Suspension Quantitative Antibacterial Test Eye Irritation Test". The test includes the following steps: taking a fresh slant culture of the test bacteria cultured for 24 hours, washing it with PBS, and diluting it with PBS to about 5.0×10 5 CFU / mL~4.5×10 6 CFU / mL bacterial suspension for later use; take a sterile test tube, first add 5.0m sample (use stock solution or dilution according to the instructions), place in 20℃±1℃ water for 5 minutes, then add 0.1m test bacterial suspension, quickly mix and immediately start timing; wait for the test bacteria and sample to interact for the specified time in the instructions, then take 1.0m test bacteria and sample mixture to inoculate 2 plates, and pour the culture medium. When the amount of bacteria cannot be counted, make a 10-fold serial dilution with PBS, select the appropriate dilution and take 1.0m to inoculate 2 plates, and count the live bacteria culture; at the same time, use PBS instead of the sample to conduct a parallel test as a positive control; the number of colonies recovered in the positive control is 1.0×10 4 CFU / mL~9.0×10 4CFU / mL. PBS and culture medium from the same batch were used as negative controls; all test samples and control samples were cultured at 36℃±1℃, and the bacterial propagules were cultured for 48 hours to observe the final results. The test was repeated 3 times to calculate the inhibition rate. The experimental bacterial flora were Malassezia furfur and Staphylococcus aureus; the results were judged as follows: the inhibition rate was <50%, which means no inhibition; the inhibition rate was >50%~90%, which means there was an inhibition; the inhibition rate was >90%, which means a strong inhibition; the test results are shown in Table 2; Table 2 Antibacterial effect As shown in Table 2, the compositions prepared in Examples 1 to 9 and the shampoos prepared in Examples 10 to 11 have an antibacterial rate of more than 90% against Malassezia furfur and Staphylococcus aureus, and have a strong antibacterial effect. Comparative Examples 1 and 9 are products using only the scutellaria root extract, which have no antibacterial effect against Malassezia furfur and Staphylococcus aureus. Comparative Examples 5 and 14 are products using only piroctone olamine salt, which have an antibacterial rate of 50-60% against Malassezia furfur and Staphylococcus aureus, and have extremely low antibacterial effect. In addition, it can be seen from the results of Examples 1 to 11 that the amount of the scutellaria root extract in the composition is 0.0-0.1%, and the amount of the piroctone olamine salt is 0.2-10%. When the dosage of piroctone olamine salt is 0.7%, the antibacterial rate of the composition against Malassezia furfur and Staphylococcus aureus is still above 90%, while in Comparative Examples 7, 11 and 16, when the dosage of piroctone olamine salt is 1%, the antibacterial rate against Malassezia furfur and Staphylococcus aureus is 70-76%. Although it has an antibacterial effect, it does not have a strong antibacterial effect. The above results show that the oil-control and anti-dandruff composition containing Scutellaria baicalensis root extract of the present invention has a strong antibacterial effect on Malassezia furfur and Staphylococcus aureus, and the combination of Scutellaria baicalensis root extract and piroctone olamine salt in the composition can significantly reduce the dosage of piroctone olamine salt, and significantly improve the antibacterial effect of the composition on Malassezia furfur and Staphylococcus aureus.

[0054] Test Example 3: The shampoos prepared in Examples 10 to 11 and Comparative Examples 9, 10, 12, 13, 14, 15, 17 and 18 were subjected to a product stability test, the test steps comprising: placing the samples at -10°C, 5°C, 25°C and 45°C for 3 months for stability observation to judge the stability of the product. If there is no precipitation instability phenomenon and no obvious color change, the stability is passed, A means no precipitation problem and no obvious color change; B means no precipitation problem but obvious color change is visible to the naked eye; C means no obvious color change but precipitation is visible to the naked eye; the test results are shown in Table 3; Table 3 Product stability test results -10℃ 5℃ 25℃ 45℃ Example 10 A A A A Embodiment 11 A A A A Comparative Example 9 A A A A Comparative Example 10 A A B B Comparative Example 12 A A B B Comparative Example 13 C C C C Comparative Example 14 A A A A Comparative Example 15 A A B B Comparative Example 17 A A B B Comparative Example 18 C C C C As shown in Table 3, the shampoos prepared in Example 10 and Example 11 all showed precipitation and discoloration after being stored at -10°C, 5°C, 25°C and 45°C for three months, while Comparative Examples 10, 12, 15 and 17, to which no antioxidant was added, all showed discoloration after being stored at various temperatures for three months. In Comparative Examples 13 and 18, the pH of the composition was not adjusted. In Comparative Examples 13 and 18, the pH of the composition was not adjusted. It was found that when the pH of the composition was not adjusted to 8.0-9.5, piroctone olamine salt and scutellaria root extract would be insoluble in water and would precipitate at the bottom of the liquid.

[0055] Test example 4: The shampoos prepared in Example 10, Example 11 and Comparative Example 11 were tested for their oil control, dandruff removal and soothing effects on human body, and the test included the following steps: Subjects: 60 subjects were selected in each group (two groups, corresponding to Example 10, Example 11 and Comparative Example 11, respectively), and the subjects met the voluntary inclusion criteria: self-reported dandruff problems, shampooing frequency was once every 2 days, no history of allergy to the ingredients of the test product, no mental illness, no severe liver and kidney disease or other autoimmune diseases, not pregnant or within six months after delivery, and did not take oral antibiotics, glucocorticoids, spironolactone and other anti-androgens and other acne treatment drugs within 4 weeks before the test, and did not use physical therapy or salicylic acid and fruit acid to treat acne. The number of subjects corresponding to Example 10 was 60, with an average age of 31.2 years, a standard error of 1.56 years, a maximum age of 55 years, a minimum age of 18 years, and a male subject ratio of 42.67%, and subjects aged 18 to 30 accounted for 57.33%. 100% of the subjects self-assessed that there were dandruff problems, 42% believed that it was too oily, 28.6% believed that the scalp was dry and itchy, and 13.68% believed that the scalp was sensitive; the number of subjects corresponding to Example 11 was 60, with an average age of 32.1 years, a standard error of 1.42 years, a maximum age of 59 years, and a minimum age of 20 years. The number of male subjects accounted for 50.7%, and subjects aged 18 to 30 accounted for 55.42%. 100% of the subjects self-assessed that there were dandruff problems, 53% believed that it was too oily, 40.68% believed that the scalp was dry and itchy, and 29.4% believed that the scalp was sensitive. The number of subjects corresponding to the proportion 11 was 60, with an average age of 32.5 years, a standard error of 1.5 years, an age of 59 years old, and a youngest age of 19 years old. Male subjects accounted for 52.6%, and subjects aged 18 to 30 accounted for 53.8%. 100% of the subjects rated themselves as having dandruff problems, 50% thought that their scalp was too oily, 43.26% thought that their scalp was dry and itchy, and 34.7% thought that their scalp was sensitive. Test method: The subject takes an appropriate amount of the test product and rubs it into foam on the palm of his hand. After applying it to the scalp, use the fingertips to fully massage and scrub. After 2 to 3 minutes, rinse it with clean water and replace the original shampoo. The frequency of use is once every 2 days. During the entire test period, you cannot be exposed to the sun for a long time, participate in outdoor activities, travel, etc. During the entire test period, you must not use cosmetics or medicines with similar effects to the product. During the test period, the subjects must not change their daily care habits; Observation results: The subjects self-assessed their dandruff, scalp itching, dry hair and scalp oiliness on a scale of 0 to 10. The higher the score, the more serious the problem. The scoring results are shown in the table below. The data in the table are the change rates of the scores on the 14th and 28th days compared to the scores on the 0th day. SPSS software was used to analyze the significant differences between the data. The significant differences indicate that the data results are statistically significant. In addition, the subjects' satisfaction with the test products was collected, including the improvement of skin problems such as dandruff and scalp itching, and the evaluation of the product's cleaning and oil control effects. The test results are shown in Table 4; Table 4 Test results of oil control, anti-dandruff and soothing effects on human body As shown in Table 4, the transparent type of the oil-controlling anti-dandruff shampoo of Example 10 and the opaque type of the oil-controlling anti-dandruff shampoo of Example 11 have significantly better oil-controlling and anti-dandruff soothing effects than the comparative example 11. The above results indicate that the shampoo prepared from the oil-controlling and anti-dandruff composition containing the root of Scutellaria baicalensis provided by the present invention can significantly improve the oil environment of the scalp and has an excellent oil-controlling and anti-dandruff effect.

[0056] Test example 5: The shampoos prepared in Example 10, Example 11 and Comparative Example 11 were subjected to a skin closed patch test. The test method was: a patch with an area not exceeding 50 mm 2 , a qualified spot test device with a depth of about 1mm. Add the test substance into the spot tester, with an amount of about 0.020-0.025g (solid or semi-solid) or 0.020-0.025mL (liquid). Apply the spot tester with the test substance and negative control to the curved side of the subject's forearm, and remove the spot tester after 24 hours. Observe the skin reaction according to the standard at 30min, 24h and 48h after removing the test substance spot tester, and record the observation results. The test subjects were 18 to 25 years old, with a total of 32 people. Scoring criteria: Grade 0: negative reaction; Grade 1: suspicious reaction, only weak erythema; Grade 2: weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present; Grade 3: strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, and herpes: the reaction may exceed the test area; Grade 4: extremely strong positive reaction (fusion herpes reaction); obvious erythema, severe infiltration, edema, and fusion herpes; the reaction exceeds the test area; the test results are shown in Table 5; Table 5 Skin occlusive patch test results Experimental Project Experimental Results Example 10 Skin occlusion patch test No adverse reactions Embodiment 11 Skin occlusion patch test No adverse reactions Comparative Example 11 Skin occlusion patch test 1 case of grade 2 adverse reaction As shown in Table 5, the shampoos prepared in Examples 10 and 11 did not cause adverse reactions to the skin, while in Comparative Example 11, when the dosage of piroctone ethanolamine salt reached 1%, the product produced a grade 2 adverse reaction to the skin.

[0057] Test Example 6: The shampoos prepared in Example 10, Example 11 and Comparative Example 11 were subjected to an acute eye irritation test; the test steps included: before the test, the rabbits were adapted to the animal room for 3 days, 24 hours before the test, and both eyes were examined with sodium fluorescein and a slit lamp after naked eye examination, 3 healthy rabbits without eye diseases were taken (female rabbits were selected from non-pregnant and non-parous rabbits), the lower eyelid of the left eye of the rabbit was gently pulled open, 0.1 mL of the test substance was dripped into the conjunctival sac, the eyelid was closed for 1 second, and the other eye was not treated as a self-control; 30 seconds after the dripping of the test substance, the eyes were rinsed with sufficient purified water with a fast flow rate that would not cause damage to the animal eyes for 30 seconds; the animal eyes were examined 1 hour, 24 hours, 48 ​​hours and 72 hours after the dripping of the test substance; each inspection was carried out in accordance with the "Acute Eye Irritation Technical Specification for Cosmetics (2015 Edition) / Corrosion Test》, the eye irritation intensity of the test substance to the eye shall be scored according to the following table "Eye Damage Scoring Criteria", and the eye irritation intensity of the test substance to the eye shall be determined according to the classification of eye irritation reaction of cosmetic products. The classification judgment criteria are: reversible eye damage (slight irritation-the cornea and iris score of the animal = 0: conjunctival congestion and / or conjunctival edema score ≤ 2, and the score drops to 0 within <7 days, mild irritation-the cornea, iris, and conjunctiva score of the animal drops to 0 within ≤7 days, irritation-the cornea, iris, and conjunctiva score of the animal drops to 0 within 8-21 days), irreversible eye damage (corrosiveness 1-the cornea, iris, and / or conjunctiva score of the animal is > 0 on the 21st day, corrosiveness 2-the eye irritation reaction score of 2 / 3 animals: corneal opacity ≥ 3 and / or iris = 2), when the cornea, iris, and conjunctiva score is 0, it can be judged as non-irritating. The test results are shown in Table 6; Table 6 Acute eye irritation test results Experimental Project Experimental Results Example 10 Acute eye irritation test Non-irritating Embodiment 11 Acute eye irritation test Non-irritating Comparative Example 11 Acute eye irritation test Mild irritation As shown in Table 6, the shampoos prepared in Examples 10 and 11 are not irritating to the eyes, while in Comparative Example 11, when the amount of piroctone ethanolamine salt used reaches 1%, the product is mildly irritating to the eyes.

[0058] Test example 7: The shampoos prepared in Example 10, Example 11 and Comparative Example 11 were subjected to an acute skin irritation test; the test steps included: before the test, the rabbits were adapted to the animal room for 3 days, 4 adult, healthy rabbits with no skin damage were taken (female rabbits were selected from non-pregnant and non-born rabbits), the hair on both sides of the spine of the back were shaved 24 hours before the test, and the left and right sides were about 3cmx3cm, 0.5mL of the test substance was directly applied to the left skin, and the application area was 2.5cmx2.5cm, and then covered with two layers of gauze and a layer of cellophane-like material, and then fixed with a non-irritating adhesive tape. The other side of the skin was not coated with the test substance, and the remaining steps were the same as the test area as a control. A closed experiment was used, the application time was 2h, and after removing the dressing, the residual test substance was removed with warm water, and the skin on the other side was treated in the same way. Observe the skin reaction of the application site 1h, 24h, 48h and 72h after removing the residual test substance, and score according to the "Skin Irritation Reaction Score" in the following table of "Safety Technical Specifications for Cosmetics (2015 Edition) "Skin Irritation / Corrosion Test"". Comprehensive evaluation is carried out based on the average score of the test animals. According to the average of the highest scores at each observation time point of 24h, 48h and 72h, the skin irritation intensity is determined according to the "Skin Irritation Intensity Grading". The judgment criteria are: 0~<0.5-non-irritating, 0.5~<2.0-mild irritating, 2.0~<6.0-moderate irritating, 6.0~8.0-strong irritating. The test results are shown in Table 7; Table 7 Acute skin irritation test results Experimental Project Experimental Results Example 10 Acute skin irritation test Non-irritating Embodiment 11 Acute skin irritation test Non-irritating Comparative Example 11 Acute skin irritation test Mild irritation As shown in Table 7, the shampoos prepared in Examples 10 and 11 are not irritating to the skin, while in Comparative Example 11, when the amount of piroctone ethanolamine salt used reaches 1%, the product is slightly irritating to the skin.

[0059] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent transformation made to the above embodiment based on the technical essence of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. An oil-controlling and anti-dandruff composition containing scutellaria root extract, characterized in that: Included by mass: Scutellaria root extract 0.05~1 part, Piroctone olamine salt 0.1~1 part, Antioxidant 0.03~1.5 parts.

2. The oil-controlling and anti-dandruff composition containing the scutellaria baicalensis root extract according to claim 1, characterized in that: The baicalin content in the scutellaria root extract is ≥80%.

3. A method for preparing the oil-controlling and anti-dandruff composition containing the scutellaria root extract according to any one of claims 1 to 2, characterized in that: The following steps are involved: Piroctone olamine salt is added into hot water to adjust the initial pH value, stirred evenly, cooled, and scutellaria root extract and antioxidant are added to adjust the final pH value to prepare an oil-controlling and anti-dandruff composition containing scutellaria root extract.

4. The preparation method according to claim 3, characterized in that: The temperature of the hot water is 70-80°C, and the temperature of the cooling is 35-40°C.

5. The preparation method according to claim 3, characterized in that: The initial pH is 8.0-9.5, and the final pH is 9.

0.

6. Use of the oil-controlling and anti-dandruff composition containing the scutellaria root extract according to any one of claims 1 to 2 in cosmetics, characterized in that: The following steps are involved: Phase A, phase B and phase C are mixed to prepare cosmetics, wherein the phase B is an oil-controlling and anti-dandruff composition containing scutellaria baicalensis root extract.

7. The use according to claim 6, characterized in that: The addition amount of the B phase is 0.3-2.3%.

8. The use according to claim 6 or 7, characterized in that: The addition amount of the B phase is preferably 0.4-1.3%.

9. The use according to claim 6, characterized in that: The phase A includes one or more of water, sodium laureth sulfate, cocamidopropyl betaine, sodium methyl cocoyl taurate and ethylene glycol distearate.

10. The use according to claim 6, characterized in that: The phase C comprises ethylhexylglycerin, phenoxyethanol, carbomer and a pH adjuster, wherein the pH adjuster is one or more of sodium hydroxide, citric acid, arginine and triethanolamine.

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