Blood filtering device for use with a clot processing system

Abstract

Disclosed herein are clot treatment systems with filtering injectors, and associated devices and methods. The filter syringe may be coupled to a catheter subsystem insertable into a patient. The filter syringe may aspirate substances (e.g., clot substances, blood, etc.) from a patient via the catheter subsystem. The filter syringe may include a plunger assembly, and the plunger assembly may include one or more filters. Each of the filters may be configured to (i) allow at least a first portion of a smoked substance (e.g., blood) to pass through at least one of the filters, and (ii) prevent at least a second portion of a smoked substance (e.g., clot substance) from passing through at least one of the filters. In some embodiments, the filtration syringe is fluidly coupled to a filtered substance subsystem, which may fluidly couple the filtration syringe to the patient or another suitable fluid outflow location.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of U.S. Provisional Application No. 63 / 326,196, filed on March 31, 2022, entitled “BLOOD-FILTERING DEVICES FOR USE WITH CLOT TREATMENT SYSTEMS,” which is incorporated herein by reference in its entirety. Technical Field

[0003] The present technology generally relates to blood filtration devices for use with clot management systems and associated methods. Background Art

[0004] Thromboembolic events are characterized by vascular obstruction. Thromboembolic diseases such as stroke, pulmonary embolism, heart attack, peripheral thrombosis, atherosclerosis, etc. affect many people. These diseases are the main causes of morbidity and mortality.

[0005] When an artery is blocked by a clot, tissue ischemia develops. If the blockage persists, the ischemia will progress to tissue infarction. However, if blood flow is quickly reestablished, the infarction will not develop or will be greatly limited. Failure to reestablish blood flow can therefore lead to limb loss, angina, myocardial infarction, stroke, or even death.

[0006] In the venous circulation, obstructive substances can also cause serious damage. Blood clots can form in the large veins of the legs and pelvis, a common condition known as deep vein thrombosis (DVT). DVT often occurs in places where there is a tendency for blood to clot (e.g., long-distance air travel, inactivity, etc.) and blood to clot (e.g., cancer; recent surgery such as plastic surgery). DVT can prevent venous blood from draining from the legs, causing swelling, ulcers, pain, and infection. DVT can also create a reservoir where blood clots can gather and then travel to other parts of the body, including the heart, lungs, brain (which can cause a stroke), abdominal organs, and / or limbs.

[0007] There are various devices for performing thrombectomy or removing clotted material to reestablish blood flow in a patient. Such devices can remove targeted clotted material and typically also remove one or more fluids (e.g., blood) along with the clotted material. These devices are typically designed to make it difficult to return the removed fluid (e.g., blood) to the patient, even though it may be advantageous to do so. For example, some existing devices include a bypass circuit that can be cumbersome to install and may require the presence of a specially trained user (e.g., a perfusionist) to operate correctly. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Many aspects of the present technology may be better understood with reference to the following drawings. The components in the drawings are not necessarily drawn to scale. Instead, emphasis is placed on clearly illustrating the principles of the present disclosure.

[0009] Figure 1 is a partially schematic side elevational view of a clot handling or clot removal system including an aspiration assembly constructed in accordance with an embodiment of the present technology.

[0010] Figure 2A is a perspective view of a pressure source including a vacuum pressure lock syringe constructed in accordance with an embodiment of the present technology.

[0011] Figure 2B According to the implementation scheme of the present technology Figure 2A A perspective view of the plunger assembly of a vacuum pressure lock syringe.

[0012] Figure 2C According to the implementation scheme of the present technology Figure 2A Exploded perspective view of the plunger assembly.

[0013] Figures 3 to 7B Shows the connection to Figure 2A Various embodiments of a syringe and a filtered material subsystem constructed according to embodiments of the present technology.

[0014] Fig. 8A is a perspective view of another plunger assembly constructed in accordance with an embodiment of the present technology.

[0015] Figure 8B is a perspective view of a filter assembly constructed in accordance with an embodiment of the present technology.

[0016] Fig. 9A and Fig. 9B is a perspective view of another filter syringe constructed in accordance with an embodiment of the present technology.

[0017] Fig.10 is a perspective view of another filter syringe constructed in accordance with an embodiment of the present technology.

[0018] Fig.11A is a perspective view of another filter syringe constructed in accordance with an embodiment of the present technology.

[0019] Fig. 11B yes Fig.11A An enlarged perspective view of the distal portion of the filter syringe, wherein other portions of the filter syringe are omitted for clarity of illustration.

[0020] Fig. 11C It is constructed according to the embodiment of the present technology Fig.11A A perspective view of the filter assembly of a filtration syringe.

[0021] Fig.11D It is along Fig. 11B The section line 11D-11D in Fig.11A Magnified side cross-sectional view of the filtration syringe.

[0022] Fig. 12A is a perspective view of a filter assembly of another filtering syringe constructed in accordance with an embodiment of the present technology.

[0023] Fig. 12B According to the implementation scheme of the present technology Fig. 11B The section line 12B-12B in Fig. 12A Cross-sectional view of a filter assembly. DETAILED DESCRIPTION

[0024] The present technology as a whole relates to a clot handling system with a filter and associated devices and methods. In some embodiments of the embodiments described in detail below, the filter can be a part of a filter syringe. The filter syringe can be connected to a catheter subsystem that can be inserted into the patient's body so that the filter syringe can remove (e.g., aspirate) substances (e.g., clot materials, blood) from the patient via the catheter subsystem. The filter syringe may include a plunger assembly, and the plunger assembly may include one or more filters. The filter may be configured to (i) allow at least a first portion of the substance removed from the patient to pass through at least one of the filters, and (ii) prevent at least a second portion of the removed substance from passing through at least one of the filters. In some embodiments, for example, one or more filters are configured to (i) allow blood to pass through at least one of the filters, and (ii) prevent clot materials from passing through at least one of the filters, so that at least one filter can "filter" blood from the substance removed from the patient.

[0025] In some embodiments, the clot handling system also includes a filtered material subsystem. The filtered material subsystem may include one or more valves and / or conduit sections that can fluidly connect the filtering syringe and the patient. In addition, in at least some embodiments, the filtered material subsystem includes a fluid drive element that is fluidly connected to the filtering syringe and can be operated to draw fluid through one or more of the filters, such as to filter blood from the clot material in the filtering syringe and / or otherwise drive blood to flow through at least a portion of the filtered material subsystem. In operation, the filtered material subsystem can be configured to (i) capture / receive all or part of the blood in the filtering syringe, and / or (ii) return / reintroduce all or part of the blood in the filtering syringe to the patient.

[0026] In some aspects of the present technology, a filter syringe can be used to perform multiple material removal (e.g., suction) cycles while remaining connected to a filtered material subsystem and / or a catheter subsystem, such that during one or more of the material removal cycles, at least a portion of the aspirated material (e.g., blood) removed from a patient can be filtered and / or reintroduced into the patient without disconnecting the filter syringe from the filtered material subsystem and / or the catheter subsystem, and / or while maintaining a substantially consistent (e.g., optimal) vacuum power / pressure and / or volume flow rate throughout the one or more material removal cycles. In some embodiments, a filter syringe can be used to perform multiple material removal cycles while remaining fluidly connected to a catheter system via a single fluid control device. In some aspects, having multiple fluid control devices (e.g., check valves, Y-connectors, etc.) between the catheter system and the pressure source can reduce the pressure / suction power applied to the catheter system by the pressure source. In some embodiments, the filter syringe can be used to perform one or more material removal cycles while remaining fluidly coupled to the catheter and returning at least a portion of the filtered blood to the patient without using any fluid control device to control / direct the flow of fluid between the filter syringe and the patient. Additionally or alternatively, at least some of the filtered material subsystems are expected to be safer and / or reduce the likelihood that clotted material removed from the patient is accidentally / unintentionally reintroduced into the patient's body. For example, at least some of the filtered material subsystems may define one or more flow paths that are configured to direct the flow of aspirated material to inhibit or prevent the filtered material (e.g., blood) from being reintroduced into the filter syringe and / or clotted material in the filter syringe from being driven back into the patient P. In these and other embodiments, at least some of the filter syringes and / or filtered material subsystems may be configured so that a user can more easily perform one or more tests or other analyses on at least a portion of the filtered material before or instead of returning the filtered material to the patient.

[0027] In the following description and in Figures 1 to 12BCertain details are set forth herein to provide a thorough understanding of various embodiments of the present technology. In other cases, well-known structures, materials, operations, and / or systems that are typically associated with intravascular procedures, blood filtration, clot removal procedures, catheters, and the like are not shown or described in detail in the following disclosure to avoid unnecessarily confusing the description of various embodiments of the present technology. However, one of ordinary skill in the art will recognize that the present technology can be practiced without one or more of the details set forth herein and / or with other structures, methods, components, and the like. In addition, although many devices and systems are described herein in the context of removing and / or treating aspirated material and / or clotted material, the present technology can be used to remove and / or treat other unwanted materials in addition to or in place of clotted material, such as thrombi, emboli, plaques, intimal hyperplasia, post-thrombotic scar tissue, and the like. Therefore, the terms "clot," "clotted material," and "aspirated material" as used herein may refer to any of the aforementioned materials, and the like.

[0028] The terminology used below should be interpreted in its broadest reasonable manner, even though it is used in conjunction with the detailed description of certain examples of the embodiments of the present disclosure. In fact, certain terms may even be emphasized below; however, any term intended to be interpreted in any limited manner will be openly and specifically defined in this detailed description section.

[0029] The accompanying drawings depict embodiments of the present technology, and are not intended to limit their scope unless explicitly stated. The sizes of the various depicted elements are not necessarily drawn to scale, and these various elements may be amplified to improve readability. Component details may be separated in the drawings to exclude these details when it is not necessary to fully understand how to make and use the present technology in details such as the position of the components and certain precise connections between such components. Many details, sizes, angles and other features shown in the drawings are only specific embodiments of the present disclosure. Therefore, without departing from the present technology, other embodiments may have other details, sizes, angles and features. In addition, it will be appreciated by those of ordinary skill in the art that other embodiments of the present technology may be implemented without some details described below.

[0030] With respect to the terms "distal" and "proximal" in this specification, unless otherwise specified, these terms may guide the relative position of the various parts of the tube system with respect to the operator and / or the position in the vasculature. In addition, as used herein, the designations "rearward," "forward," "upward," "downward," etc. are not intended to limit the referenced components to a particular orientation. It should be understood that such designations refer to the orientation of the referenced components as shown in the accompanying drawings; the systems of the present technology may be used in any orientation suitable for the user.

[0031] Figure 11 is a partial schematic side view of a clot handling or clot removal system including an aspiration assembly 10 ("assembly 10") constructed according to an embodiment of the present technology. In the illustrated embodiment, assembly 10 includes a catheter subsystem 100, a tubing subsystem 120, a pressure source 130, and a filtered material subsystem 170. The catheter subsystem 100 includes a catheter 102 (e.g., a suction catheter) including an elongated shaft defining an inner cavity 104 and having a distal portion 103a and a proximal portion 103b. The catheter 102 can be advanced intravascularly to a treatment site within a blood vessel of a patient P, such that, for example, the distal portion 103a is positioned in and / or proximal to the clot material within the blood vessel. The catheter subsystem 100 also includes a valve 106, which can be integral with or connected to the proximal portion 103b of the catheter 102.

[0032] In general, the clot removal system (i) may include features substantially similar or identical to the features of the clot removal system described in detail in U.S. patent application Ser. No. 16 / 536,185, filed on August 8, 2019, entitled “SYSTEM FORTREATING EMBOLISM AND ASSOCIATED DEVICES AND METHODS,” the entirety of which is incorporated herein by reference, and / or (ii) may be used to treat / remove clotted material from a patient (e.g., a human patient) using any of the methods described in detail therein. In some embodiments, the catheter subsystem 100 may include features that are at least substantially similar in structure and function or are identical in structure and function to those features of the catheter disclosed in (i) U.S. patent application publication No. 17 / 529,018, filed on November 17, 2021, entitled “CATHETERS HAVING SHAPEDDISTAL PORTIONS, AND ASSOCIATED SYSTEMS ANDMETHODS” and / or (ii) U.S. patent application publication No. 17 / 529,064, filed on November 17, 2021, entitled “CATHETERS HAVING STEERABLE DISTAL PORTIONS, AND ASSOCIATED SYSTEMS ANDMETHODS,” each of which is incorporated herein by reference in its entirety.

[0033] In the illustrated embodiment, the valve 106 includes a distal portion 107a, a proximal portion 107b, and a lumen 109 extending from the distal portion 107a through the valve to the proximal portion 107b. In some embodiments, the valve 106 is a hemostatic valve that is configured to maintain hemostasis during a clot removal procedure by preventing fluid from flowing through the valve 106 in a proximal direction when various components such as a delivery sheath, a pull member, a guidewire, an interventional device, other aspiration catheters, etc. are inserted through the valve 106 to be delivered to a treatment site in a blood vessel through the catheter 102. The valve 106 also includes one or more branches or side ports 108 that are configured to fluidically couple the lumen 104 of the catheter 102 to the tubing subsystem 120. In the illustrated embodiment, the valve 106 includes a button 101 that can be actuated (e.g., pressed) to open the tube within the lumen 109. In some embodiments, the valve 106 can be a valve of the type disclosed in U.S. Patent Application No. 16 / 117,519, filed on August 30, 2018, and entitled “HEMOSTASIS VALVES AND METHODS OF USE”, which is incorporated herein by reference in its entirety. In some embodiments, the proximal portion 107b of the valve 106 is also configured to be removably coupled (e.g., via a snap-fit ​​arrangement) to a filtering device, such as described below with reference to FIG. 2A to FIG. 2C One or more of the filter syringes described in more detail.

[0034] The tubing subsystem 120 fluidly couples the catheter subsystem 100 to a pressure source 130. More specifically, the tubing subsystem 120 may include one or more tubing segments 124 (each labeled as a first tubing segment 124a and a second tubing segment 124b), at least one fluid control device 126 (e.g., a valve), and at least one connector 128 for fluidly coupling the tubing subsystem 120 to the pressure source 130 and / or other suitable components. More specifically, in the illustrated embodiment, the fluid control device 126 is a plug valve that is (i) fluidly coupled to the side port 108 of the valve 106 via the first tubing segment 124a, and (ii) fluidly coupled to the connector 128 via the second tubing segment 124b. In at least some embodiments, fluid control device 126 is a three-way stopcock and includes a free port or inlet configured to allow a user to fluidly couple an additional device to catheter subsystem 100 while pressure source 130 is also fluidly coupled to catheter subsystem 100, e.g., to reintroduce filtered blood into a patient, as described below with reference to Figure 3Detailed description. The fluid control device 126 can be operated by a user from the outside to regulate the flow of fluid through the fluid control device, and specifically regulate the flow of fluid from the lumen 104 of the catheter 102 to the pressure source 130. In other embodiments, the fluid control device 126 can be a clamp that can be actuated (e.g., compressed or squeezed by the user's hand) to partially or completely restrict the flow of fluid through the first conduit segment 124a and / or the second conduit segment 124b. In still other embodiments, the fluid control device 126 can be omitted and its function is incorporated into the pressure source 130.

[0035] The pressure source 130 is configured to generate (eg, form, create, fill, accumulate) a vacuum (eg, a negative relative pressure) and store the vacuum for subsequent application to the catheter subsystem 100. FIG. 2A to FIG. 2C and 9A to 12B Further details of suitable pressure sources are described in detail. In some embodiments, the pressure source 130 draws fluid (e.g., blood), clot material, and / or other substances from the patient P during the clot removal process. In the illustrated embodiment, the pressure source 130 is fluidly coupled to the filtered substance subsystem 170. The filtered substance subsystem 170 can receive the drawn fluid, clot material, and / or other substances from the pressure source 130 and filter the fluid from the other substances. In some embodiments, the filtered substance subsystem 170 can be fluidly coupled to the patient P and configured to reintroduce the drawn fluid (e.g., blood) into the patient. Figures 3 to 7B Additional details regarding suitable filtered material subsystems are described in greater detail. Additionally, in at least some embodiments, filtered material subsystem 170 may be omitted, and pressure source 130 may be used to transfer the aspirated fluid (e.g., blood) to the patient (e.g., intravenously, via fluid control device 126, via one of side ports 108, etc.) or any other suitable location.

[0036] During operation of the assembly 10, the user may first close the fluid control device 126 to accumulate vacuum pressure within the pressure source 130 (e.g., the vacuum chamber of the pressure source 130) before activating the pressure source 130. In some embodiments, the user may control or select the volume of the vacuum generated. In this way, the pressure source 130 is filled with vacuum before the pressure source 130 is fluidly connected to the catheter subsystem 100. In order to aspirate the lumen 104 of the catheter 102, the user may open the fluid control device 126 to fluidly connect the pressure source 130 to the catheter subsystem 100, and thereby apply or release the vacuum stored in the pressure source 130 to the lumen 104 of the catheter 102. The opening of the fluid control device 126 instantly or almost instantly applies the stored vacuum pressure to the tubing subsystem 120 and the catheter 102, thereby generating suction on the entire catheter 102. Specifically, suction is applied at the distal portion 103a of the catheter 102. In one aspect of the present technology, pre-filling or storing a vacuum prior to applying a vacuum to the lumen 104 of the catheter 102 is expected to generate greater suction (and corresponding fluid flow rate) at and / or near the distal portion 103a of the catheter 102 than simply activating the pressure source 130 while the pressure source is fluidly connected to the catheter 102. The suction generated by applying the stored vacuum can be used to aspirate or otherwise remove aspirated material from within a blood vessel of a human patient. The aspirated material can be received by the pressure source 130, and at least a portion of the aspirated material can be filtered, transferred to the filtered material subsystem 170, and / or returned to / reintroduced into the patient P or another suitable outflow location.

[0037] Figure 2A is a perspective view of a pressure source 230 ("filter syringe 230") comprising a vacuum pressure locking and / or filtering syringe constructed in accordance with an embodiment of the present technology. In some embodiments, the filter syringe 230 may include some features substantially similar or identical to the features of any of the syringes described in detail in U.S. Patent Application No. 17 / 396,426, filed on August 6, 2021, and entitled "AUTOMATICALLY LOCKING VACUUM SYRINGES, AND ASSOCIATED SYSTEMS AND METHODS," which is incorporated herein by reference in its entirety.

[0038] In the illustrated embodiment, the filter syringe 230 includes a barrel assembly 240 and a filter plunger assembly 250 ("plunger assembly 250"). The barrel assembly 240 includes a chamber or barrel 242, a tip 244 extending distally from the barrel 242, and an inner cavity or orifice 246 extending through the tip 244 and the barrel 242. In some embodiments, the barrel assembly 240 includes a locking member 248. For clarity, the barrel 242 is Figure 2A is shown as transparent.

[0039] The plunger assembly 250 may include a body or plunger 252 having a first (e.g., distal) end portion 253a defining a distal end terminus of the plunger 252 and a second (e.g., proximal) end portion 253b opposite the first end portion 253a and defining a proximal end terminus of the plunger 252. The plunger assembly 250 may also include a seal 254, a port or valve 258 (such as a Luer-activated valve or any other suitable valve), and an inner cavity 256 (at least partially or completely extending through the plunger 252) between the first end portion 253a and the second end portion 253b. Figure 2A 250). In addition, the plunger assembly 250 may include a handle 251 to improve the manipulation of the plunger assembly 250 by the user. In the illustrated embodiment, the seal 254 is positioned proximate to the first end portion 253a, and the valve 258 and the handle 251 are positioned proximate to the second end portion 253b. The lumen 256 may be fluidly coupled to the valve 258, and the valve 258 may be fluidly coupled to the filtered material subsystem 170 and / or the patient P ( Figure 1 ) so that the fluid in the inner cavity 256 can flow to and / or toward the filtered material subsystem 170 and / or patient P via valve 258.

[0040] The plunger assembly 250 also includes a filter assembly 260. In the illustrated embodiment, the filter assembly 260 is positioned at the first end portion 253a of the plunger 252 and at the distal end portion of the lumen 256. In other embodiments, the filter assembly 260 can be positioned near the second end portion 253b, proximal to the lumen 256, and / or relative to the lumen 256 and / or at any other suitable position within the filtering syringe 230. The filter assembly 260 may include one or more filters 262 (which may also be referred to as "filter elements", "filter stages", etc.). As described in detail below, fluid (e.g., blood) can be pulled through the filter 262 into the lumen 256 and out of the valve 258.

[0041] At least a portion of the plunger assembly 250 can be advanced distally and proximally through the barrel 242. In the illustrated embodiment, the seal 254 can sealingly engage the interior surface of the barrel 242 and form a substantially fluid-impermeable seal therewith. Figure 1 and Figure 2A , the tip 244 can be configured to removably couple the filter syringe 230 to the tubing subsystem 120. In the illustrated embodiment, the tip 244 is a Luer connector that can be coupled to the connector 128 and / or the proximal portion 107b of the valve 106 via one or more suitable adapters. In some embodiments, the barrel 242 can be made of a transparent material that allows a user to see the contents of the barrel 242 (e.g., the aspirated substance).

[0042] Continue to refer to Figure 1 and Figure 2ADuring operation of the assembly 10, the user may first close the fluid control device 126, and then grasp the plunger assembly 250 and / or the barrel assembly 240 to at least partially withdraw (e.g., retract) the plunger 252 from the barrel 242, thereby generating a vacuum in the barrel 242. In some embodiments, once the user has withdrawn the plunger 252 to a predetermined volume, the locking member 248 may automatically engage the plunger 252 to lock the plunger 252 relative to the barrel 242. In other embodiments, the plunger 252 may be locked by rotating the plunger 252 relative to the barrel 242 to engage the locking member 248. In some such embodiments, the user may control the volume of the vacuum (by withdrawing the plunger 252 more or less) to provide a desired amount or level of suction / aspiration when the fluid control device 126 is opened. In other embodiments, the filtration syringe 230 may not be a locking syringe, and the user may instead hold the plunger 252 in place relative to the barrel 242. In some embodiments, the syringe has a volume of about 60cc or less. With the plunger 252 withdrawn, the user can open the fluid control device 126 to draw material (e.g., clot material, body fluid, etc.) through the lumen 104 and into the barrel 242. The filters 262 of the filter assembly 260 can be selected to allow selected materials and / or fluids (e.g., one or more vascular fluids, blood, plasma, water, hemoglobin, white blood cells, etc.) drawn from the patient to pass through the filter. For example, one or more of the filters 262 can (i) allow a first portion of the drawn material (e.g., blood, plasma, etc.) to pass through the filter assembly 260, and (ii) prevent at least a second portion of the drawn material (e.g., clot material, thrombus, embolus, etc.) from passing through the filter assembly 260. Thus, when pressure is applied to lumen 256, filter assembly 260 can "filter" or otherwise separate a first portion of the aspirated material (e.g., blood) from a second portion of the aspirated material (e.g., clot material).

[0043] Figure 2B yes Figure 2A A perspective view of the plunger assembly 250 is shown. Figure 2C yes Figure 2A An exploded perspective view of the plunger assembly 250 is provided. Figure 2B and Figure 2CIn the illustrated embodiment, the filter assembly 260 includes a first filter 262a and a second filter 262b. Each of the filters 262a-b can be formed of polyester, polyamide, blood compatible material, a combination thereof and / or any other suitable material. The first filter 262a and the second filter 262b can provide multi-stage filtration, for example, to extend the life of the filter assembly 260 and / or to provide an increased filtration surface area. The first filter 262a and the second filter 262b can have the same, substantially similar or different size, thickness, porosity, etc. In at least some embodiments, for example, the first filter 262a has a relatively large / coarse porosity of about 200 microns, and the second filter 262b has a relatively small / fine porosity of about 40 microns. In such embodiments, the first filter 262a can be configured to have relative elasticity to negative pressure, large aspirated thrombus and / or cleaning, and the second filter 262b can be configured to filter blood, microemboli, etc. In other embodiments, the first filter 262a and / or the second filter 262b may have any other suitable porosity, such as less than 40 microns, greater than 200 microns, and / or any porosity therebetween. In these and other embodiments, the first filter 262a and the second filter 262b may have any other suitable configuration.

[0044] In some embodiments, one or more of the filters 262 may be removably coupled to the plunger assembly 250 (e.g., to form the filter assembly 260) such that one or more of the filters 262 may be removed from the plunger assembly 250, such as for cleaning, reuse, and / or disposal. Alternatively or additionally, one or more of the filters 262 may be coupled to, integrally formed with, or otherwise form a one-piece assembly with the plunger 252 such that the plunger 252 may be removed from the barrel 242 to clean, reuse, and / or dispose of the plunger 252 and / or the filters after use. Although the first filter 262a and the second filter 262b are in the Figure 2C In the illustrated embodiment, the first filter 262a and the second filter 262b have a circular shape, but in other embodiments, one or both of the filters 262a-b can have a disk, pleats, cones, cylinders, or any other suitable shape. Figure 2C In the illustrated embodiment, the first filter 262a and the second filter 262b are positioned adjacent to each other, but in other embodiments, the first filter 262a and the second filter 262b can be spaced apart from each other. In at least some embodiments, for example, the first filter 262a can be positioned proximate to the distal end portion 253a of the plunger assembly 250, and the second filter 262b can be positioned opposite the first filter 262a proximate to the proximal end portion 253b of the plunger assembly 250. Although in Figure 2CIn the illustrated embodiment, the filter assembly 260 includes two filters, but in other embodiments, the filter assembly 260 may include more or fewer filters 262 , such as one, more than two, or any other suitable number of filters 262 .

[0045] refer to Figure 2C , the lumen 256 has a first (e.g., distal) hole or opening 257a and a second (e.g., proximal) hole or opening 257b opposite the first opening 257a. In the illustrated embodiment, the first opening 257a is positioned to pass through the filter assembly 260 from the barrel 242 ( Figure 2A ) receives fluid, and the second opening 257b is fluidly coupled to the valve 258. In some aspects of the present technology, it is expected that the inner cavity 256 will be less likely to be substantially blocked during use because it receives fluid filtered by the filter assembly 260.

[0046] Figures 3 to 7B Embodiments of filtered material subsystems 370-770 constructed according to embodiments of the present technology are shown, respectively. Each of the various filtered material subsystems 370-770 may include features that are substantially similar in structure and function or identical in structure and function to each other and / or substantially similar in structure and function or identical in structure and function to the above referenced Figure 1 The corresponding features of the filtered matter subsystem 170 described in detail may operate in a manner substantially similar or identical to each other and / or substantially similar or identical to the filtered matter subsystem 170. In addition, one or more of the different features of the filtered matter subsystems 370-770 of the present technology may be combined or omitted.

[0047] Figure 3 is connected to the embodiment of the present technology Figure 1 Components 10 Figure 2A 1. A perspective view of the filtration syringe 230 of FIG. 1. In the illustrated embodiment, the tip 244 of the barrel assembly 240 is fluidly coupled to the connector 128, and the valve 258 of the plunger assembly 250 is fluidly coupled to the filtered material subsystem 370, which is substantially similar in structure and / or function to the filtered material subsystem 370. Figure 1 Filtered material subsystem 170. In the illustrated embodiment, filtered material subsystem 370 includes a syringe ("syringe 370"). In other embodiments, filtered material subsystem 370 may include a blood bag, container and / or any other suitable fluid reservoir.

[0048] During a procedure involving assembly 10, such as a clot handling and / or clot removal procedure, the user may open fluid control device 126 to fill a vacuum in barrel 242 after withdrawing plunger 252, thereby drawing aspirated substance AM into barrel 242, as described with reference to FIG. Figure 1 and Figure 2A Detailed description. The aspirated substance AM may include a first (e.g., filterable) portion FM ("first substance FM", "filterable substance FM", etc.) and a second (e.g., non-filterable) portion UFM ("second substance UFM", "non-filterable substance UFM", etc.). For example, the first substance FM may include blood and the second substance UFM may include clotted substance.

[0049] After aspirating the aspirated substance AM, the user may close the fluid control device 126 to inhibit the aspirated substance AM from flowing back into the assembly 10 through the fluid control device 126 and / or otherwise flowing to the patient P. Figure 1 ). When the aspirated substance AM is within the barrel 242, the user may filter the aspirated substance AM using the filter assembly 260 to separate all or part of the first substance FM from the second substance UFM. More specifically, the user may apply force / pressure to the valve 258 using the syringe 370 to draw the aspirated substance AM toward the filter assembly 260 and cause at least a portion of the first substance FM to flow toward the syringe 370 through the filter assembly 260. To apply force / pressure to the valve 258, the user may (i) move the syringe 370 toward the plunger assembly 250 in a first (e.g., distal) direction D1 to depress the plunger 252 through the barrel 242, thereby driving the aspirated substance AM against the filter assembly 260 and through the lumen 256 to the syringe 370, and / or (ii) actuate the syringe 370 (e.g., by withdrawing its plunger in a second direction D2) to draw the first substance FM through the filter assembly 260 without depressing the plunger 252.

[0050] Once all or part of the first substance FM is within the syringe 370, the user may (i) disconnect the syringe 370 from the valve 258 and / or (ii) return at least a portion of the first substance FM (e.g., blood) to the patient. For example, the user may connect the syringe 370 to the fluid control device 126 (e.g., as described above with reference to FIG. Figure 1 The free port or inlet described above) and actuating the syringe 370 to inject all or part of the first substance FM in the syringe 370 into the catheter 102 ( Figure 1 ) and in the patient's body. As another example, the user can use the syringe 370 through the side port 108 ( Figure 1) and / or any other suitable method or technique to intravenously inject all or part of the first filtered substance FM into the patient. Additionally or alternatively, the user may (i) disconnect the filter syringe 230 from the assembly 10, (ii) remove all or part of the remaining aspirated substance AM and / or the second substance UFM from the barrel 242, and / or (iii) perform one or more subsequent aspirations using the filter syringe 230 to remove additional substances from the patient. In some embodiments, for example, the user may flush all or part of the aspirated substance AM from the filter syringe 230 via the valve 258 by, for example, fluidly coupling the valve 258 to a fluid source and causing the fluid to at least partially flow through the filter syringe 230 and toward and / or out of the tip 244. In other embodiments, the user may place the tip 244 of the filter syringe 230 into a bowl containing a saline solution or any other suitable washing / rinsing solution, withdraw the plunger 252 to draw at least a portion of the saline solution into the barrel 242 (e.g., to mix with any aspirated substance AM contained therein), and then depress the plunger 252 to expel all or a portion of the aspirated substance AM and / or the saline solution from the barrel 242. In these and other embodiments, the user may degas the filter syringe 230 prior to aspirating the substance from the patient. For example, the user may use the syringe 370 to (i) inject a liquid (e.g., saline) into the filter syringe 230 and / or (ii) draw fluid (e.g., air, liquid, etc.) from the filter syringe via, for example, the valve 258 on the filter syringe 230. Additionally or alternatively, the user may degas the syringe 370 prior to reintroducing the first filtered substance FM into the patient, for example, by actuating the plunger of the syringe 370 to remove air bubbles from the barrel of the syringe.

[0051] Figure 4 is coupled to the filtered material subsystem 470 according to an embodiment of the present technology Figure 2A , an enlarged side view of the filtering syringe 230. In the illustrated embodiment, the filtered substance subsystem 470 includes a fluid control device 472 and a conduit section 474. The conduit section 474 can fluidly connect the filtering syringe 230 to the patient P or another suitable outflow location via the fluid control device 472. The fluid control device 472 may include a one-way valve, a check valve, or any other suitable fluid control device. A first (e.g., distal) end of the fluid control device 472 is fluidly connected to the valve 258 of the filtering syringe 230, and a second (e.g., proximal) end of the fluid control device 472 is fluidly connected to the conduit section 474. In the illustrated embodiment, the fluid control device 472 is configured to allow a fluid (e.g., a first substance FM, Figure 3) in a second direction D2 (e.g., through the fluid control device 472 to and / or toward the patient P), and is configured to substantially or completely prevent fluid from flowing in a first direction D1 (e.g., opposite to the second direction D2, from the patient P toward the filter syringe 230).

[0052] In operation, a user may couple the filter syringe 230 to the assembly 10 (eg, via the connector 128, Figure 1 ) and actuate assembly 10 to aspirate the aspirated substance AM from patient P, as previously described herein. The user may then close fluid control device 126 ( Figure 1 ) and moves the plunger 252 in the first direction D1 to filter the aspirated substance AM. Specifically, the movement of the plunger 252 in the first direction D1 drives the first substance FM in the second direction D2 through the filter assembly 260, the lumen 256 and the valve 258 and into the filtered substance subsystem 470. In some embodiments, at least a portion of the first substance FM can be returned to / reintroduced into the patient P via the conduit 474.

[0053] In some aspects of the present technology, the filter syringe 230 may remain coupled to the filtered material subsystem 470 during one or more aspiration cycles, for example, unless or until the filter syringe 230 is filled with the second material UFM ( Figure 3 ) and / or the user determines that the filter syringe 230 should be cleaned / flushed. Therefore, in at least some aspects of the present technology, it is expected that the filter syringe 230 and the filtered substance subsystem 470 form a generally or substantially closed-loop system that is operable to remove the aspirated substance from the patient and return at least a portion of the aspirated substance (e.g., the first substance FM) to the patient P.

[0054] Figure 5 is coupled to the filtered material subsystem 570 according to an embodiment of the present technology Figure 2A 230. In the illustrated embodiment, the filtered material subsystem 570 includes two fluid control devices 572a-b (i.e., a first fluid control device 572a and a second fluid control device 572b), two pipeline segments 574a-b (i.e., a first pipeline segment 574a and a second pipeline segment 574b), and a fluid drive component 576. Each of the fluid control devices 572a-b may be structurally and / or functionally similar to the fluid control device 572a. Figure 4 The fluid control device 472 is substantially similar or identical to the fluid control device 472. The fluid drive component 576 may include a syringe (e.g., "drive syringe 576"), which may be similar in structure and / or function to the fluid control device 472 of the embodiment of the present invention. Figure 325. The first fluid control device 572a can be coupled to the valve 258 of the filter syringe 230; the first conduit segment 574a can be (i) positioned between the first fluid control device 572a and the second fluid control device 572b, and (ii) fluidly coupled to the drive syringe 576; and the second conduit segment 574b can be fluidly coupled to the second fluid control device 572b opposite the first conduit segment 574a. In the illustrated embodiment, the first conduit segment 574a is a "T-shaped" conduit segment, and the drive syringe 576 has a plunger 578 that can be withdrawn / depressed to drive fluid into / out of the drive syringe 576.

[0055] The first fluid control device 572a and the second fluid control device 572b are each a one-way valve positioned to allow a fluid (e.g., a first substance FM, Figure 3 ) in a second direction D2 (e.g., from the filter syringe 230 toward the patient P), and is positioned to substantially or completely prevent fluid from flowing in a direction opposite to the second direction D2 (e.g., from the patient P toward the filter syringe 230). Thus, the first fluid control device 572a and the second fluid control device 572b can define one or more flow paths FP (i.e., a first flow path FP1 and a second flow path FP2) through the filtered substance subsystem 570. The drive syringe 576 is configured to control the flow of fluid through the filtered substance subsystem 570 (e.g., through the first flow path FP1 and the second flow path FP2). In the illustrated embodiment, for example, a user can withdraw the plunger 578 to drive fluid from the filter syringe 230 along the first flow path FP1 through the first fluid control device 572a and into the drive syringe 576. When the user withdraws the plunger 578, the second fluid control device 572b can substantially or completely prevent the drive syringe 576 from drawing fluid from the patient P (e.g., because the force / pressure applied to the second fluid control device 572b when the plunger 578 is withdrawn is in a direction opposite to the second direction D2).

[0056] After the user has withdrawn the plunger 578, the user may depress the plunger 578 to drive fluid from the drive syringe 576 along the second flow path FP2 through the second fluid control device 572b into the second conduit segment 574b, and toward the patient P. When the user depresses the plunger 578, the first fluid control device 572a may substantially or completely prevent the drive syringe 576 from driving fluid to flow into the filter syringe 230 (e.g., because the force / pressure applied to the first fluid control device 572a when the user depresses the plunger 578 is in a direction opposite to the second direction D2). In some aspects of the present technology, this may inhibit or prevent the filtered substance (e.g., the first substance FM) from being reintroduced into the filter syringe 230 and / or the aspirated substance AM in the filter syringe 230 from being driven back into the patient P (e.g., through the catheter 102, Figure 1 ).

[0057] In some aspects of the present technology, the user can operate the drive syringe 576 to degas the filtered material subsystem 570 and / or the filter syringe 230. Degassing the filter syringe 230 can be substantially similar to the filtering process described above, but wherein the drive syringe 576 draws air and / or other fluids from the filter syringe 230 instead of the first material FM. In other aspects of the present technology, after the user has withdrawn the plunger 578 but before or instead of depressing the plunger 578, the user can (i) disconnect the drive syringe 576 from the first conduit section 574a, (ii) perform one or more tests on the material in the drive syringe 576, (iii) transfer all or part of the material in the drive syringe 576 to another site and / or patient, (iv) take one or more images of the material in the drive syringe 576, and / or flush the filter syringe 230 and / or the drive syringe 576.

[0058] Figure 6 is coupled to the filtered material subsystem 670 according to an embodiment of the present technology Figure 2A 6. A side view of the filter syringe 230 is shown. The filtered material subsystem 670 may include a substantially similar Figure 5 1 and 10. Various aspects of the filtered material subsystem 570 of the embodiment of the present invention are shown in FIG. 5, wherein similar reference numerals (e.g., first conduit segment 674a vs. Figure 5 In addition, the filtered material subsystem 670 includes a second locking syringe 630 ("second syringe 630"), which can be substantially similar in structure and / or function to the first conduit section 574a. Figure 2A Filter syringe 230 ("first filter syringe 230"). In some embodiments, second syringe 630 may not include a filter assembly or multiple filters.

[0059] In operation, the plunger 652 of the second syringe 630 can be withdrawn and then locked to generate and store a vacuum within the second syringe 630. Once the substance is drawn into the filtering syringe 230, the vacuum pressure in the second syringe 630 can automatically draw some of the drawn substance along the first flow path FP1 toward and through the filter assembly 260, so that some of the filtered blood can be drawn into the second syringe 630. In order to completely filter the substance from the filtering syringe 230 into the filtered substance subsystem 670, the locking component 248 can be unlocked to allow the plunger 252 to move in the first direction D1 to balance the pressure between the filtering syringe 230 and the second syringe 630. After the filtered substance FM is drawn into the second syringe 630, the second plunger 652 can be unlocked (via, for example, the locking component 648) and depressed to drive the fluid from the second syringe 630 along the second flow path FP2 from the second syringe 630 to and / or toward the patient P.

[0060] Fig. 7A is coupled to the filtered material subsystem 770 according to an embodiment of the present technology Figure 2A 230. The filtered material subsystem 770 may include a substantially similar Figure 5 1 and 10. Various aspects of the filtered material subsystem 570 of the present invention are shown with similar reference numerals (e.g., drive syringe 776 vs. Figure 5 780) indicates similar elements. In addition, the filtered material subsystem 770 includes a fluid control device 780. The fluid control device 780 may include a three-way valve, a stopcock or any other suitable fluid control device. Each of the filtering syringe 230, the driving syringe 776 and the pipeline section 774 can be fluidically connected to the fluid control device 780. The fluid control device 780 can be configured to selectively control the flow of fluid through one or more of the flow paths FP1, FP2 within the filtered material subsystem 770. In the illustrated embodiment, for example, the fluid control device 780 includes an actuating element or a joystick 782, which is operable to cause the fluid control device 780 to be in (i) a first configuration ( Fig. 7A) and (ii) a second configuration (not shown), in which the first flow path FP1 is open (e.g., the fluid control device 780 allows fluid to flow from the filter syringe 230 toward and / or into the drive syringe 776) and the second flow path FP2 is closed (e.g., the fluid control device 780 partially or completely prevents the fluid from entering the conduit segment 774), and in which the second configuration, the first flow path FP1 is closed (e.g., the fluid control device 780 partially or completely prevents the fluid from entering the filter syringe 230) and the second flow path FP2 is open (e.g., the fluid control device 780 allows fluid to flow from the drive syringe 776 toward and / or into the conduit segment 774).

[0061] In operation, a user may transition the fluid control device 780 to the first configuration and withdraw the plunger 778 to drive fluid along the first flow path FP1, e.g., from the filter syringe 230 through the fluid control device 780 and into the drive syringe 776. When the user withdraws the plunger 778, the fluid control device 780 may substantially or completely prevent the drive syringe 776 from drawing fluid from the patient P when the tubing segment 774 is fluidly coupled to the patient P (e.g., because the second flow path FP2 is closed when the fluid control device 780 is in the first configuration). After the user has withdrawn the plunger 778, the user may transition the fluid control device 780 from the first configuration toward and / or to the second configuration and depress the plunger 778 to drive fluid from the drive syringe 776 along the second flow path FP2 through the fluid control device 780 into the tubing segment 774 and toward the patient P. When the user depresses the plunger 778, the fluid control device 780 can substantially or completely prevent the drive syringe 776 from driving fluid into the filtration syringe 230 because the first flow path FP1 is closed when the stopcock is in the second configuration. In some embodiments, after depressing the plunger 778, the user can perform one or more additional aspiration cycles using the filtered material subsystem 770 without disconnecting the filtration syringe 230 or the drive syringe 776 from the fluid control device 780.

[0062] Figure 7B 770 coupled to the filtered material subsystem according to additional embodiments of the present technology. Figure 2A Filter syringe 230. Figure 7B , driving the syringe 776 ( Fig. 7A) has been disconnected from the fluid control device 780, so that the fluid control device 780 has a free hole or port 784. In addition, the fluid control device 780 has been transformed into a third configuration in which fluid can flow from the filtering syringe 230 through the fluid control device 780 and toward the patient P along the third flow path FP3. Therefore, when the fluid control device 780 is in the third configuration, the user can drive fluid through the filtered material subsystem 770 by moving the plunger 252 in the first direction D1, as described above with reference to Figure 4 In some aspects of the present technology, the user can degas / flush the filter syringe 230 and / or the tubing segment 774 via the free port 784. For example, the user can transform the fluid control device 780 to the first configuration ( Fig. 7A ) along the first flow path FP1 ( Fig. 7A ) degassing / flushing the filter syringe 230, and / or switching the fluid control device 780 to a second configuration (not shown) to flow along the second flow path FP2 ( Fig. 7A ) Degas / flush pipeline section 774.

[0063] Fig. 8A 850 is a perspective view of another plunger assembly 850 constructed in accordance with an embodiment of the present technology. The plunger assembly 850 may include FIG. 2A to FIG. 2C The plunger assembly 250 is substantially similar or identical in structure and / or function to at least some aspects, wherein similar reference numerals (e.g., lumen 856 vs. FIG. 2A to FIG. 2C The inner cavity 256 of the piston assembly 250 indicates substantially similar or identical aspects. In addition, in the illustrated embodiment, the piston assembly 250 also includes a pleated filter assembly 860. Figure 8B In the illustrated embodiment, the pleated filter assembly 860 includes a first filter 862a and a second filter 862b. In other embodiments, the pleated filter assembly 860 may include more or fewer filters. In these and other embodiments, the pleated filter assembly 860 may have a greater filtration surface area than a substantially flat or planar filter / filter assembly. Thus, in some aspects of the present technology, the pleated filter assembly 860 may include a first filter 862a and a second filter 862b. In other embodiments, the pleated filter assembly 860 may include more or fewer filters. In these and other embodiments, the pleated filter assembly 860 may have a greater filtration surface area than a substantially flat or planar filter / filter assembly. FIG. 2A to FIG. 2C Pleated filter assembly 860 may have an increased filtration surface area compared to filter assembly 260 while having a substantially similar or identical cross-sectional area as filter assembly 260 .

[0064] Fig. 9A and Fig. 9B is a perspective view of another filter syringe 930 constructed in accordance with an embodiment of the present technology. The filter syringe 930 may include FIG. 2A to FIG. 2CThe filter syringe 230 is substantially similar or identical in structure and / or function to at least some aspects, wherein similar reference numerals (e.g., lumen 946 vs. Figure 2A In the illustrated embodiment, the filter syringe 930 includes Fig. 8A In other embodiments, the filter syringe 930 may include FIG. 2A to FIG. 2C The plunger assembly 250 or any other suitable plunger assembly. In addition, the filter syringe 930 includes a removable end cap 943 (which may also be referred to as a "locking end cap", "twist end cap", "removable end cap", etc.). The removable end cap 943 can be releasably coupled to the barrel 242. Fig. 9B , the removable end cap 943 can be configured to cooperatively engage with the coupling portion 945 of the barrel 242. In the illustrated embodiment, the coupling portion 945 includes one or more coupling slots or grooves 947, and the removable end cap 943 includes one or more tabs or protrusions 949 (which can extend radially from the inner surface of the end cap 943, such as Fig. 9B ), and each coupling slot 947 is configured to slidably receive a corresponding tab 949 to couple the removable end cap 943 to the barrel 942. In at least some embodiments, the removable end cap 943 may include an O-ring or other sealing element (in Fig. 9B 942 ), the O-ring or other sealing element forms a substantially fluid-impermeable seal with the barrel 942 when the removable end cap 943 is connected to the barrel 942, for example, to maintain the vacuum pressure generated / stored within the barrel 942, and / or to inhibit or prevent the fluid and / or other pumped material within the barrel 942 from leaking out of the barrel 942.

[0065] In operation, the user can rotate the removable end cap 943 relative to the barrel 942 (e.g., in the direction indicated by arrow R) to couple and / or detach the removable end cap 943 to the barrel 942. The user can detach the removable end cap 943 from the barrel 942 after performing one or more material removal cycles, for example, to flush or remove any fluid, clotted material, or other aspirated material collected in the barrel 942. After flushing / removing material collected in the barrel 942, the user can reconnect the removable end cap 943 to the barrel 942 and use the filter syringe 930 alone or with the reference syringe 930. Figures 3 to 7B Any of the filtered material systems described in detail may be combined to perform one or more additional material removal cycles.

[0066] Fig.10 is a perspective view of another filter syringe 1030 constructed in accordance with an embodiment of the present technology. The filter syringe 1030 may include FIG. 2A to FIG. 2CFilter syringe 230 and / or FIG. 9A to FIG. 9B The filter syringe 930 is substantially similar or identical in structure and / or function to at least some aspects, wherein similar numbers (e.g., the barrel 1042 and the barrel 1042 are substantially similar or identical to the filter syringe 930 in structure and / or function. Figure 2A The cylinder 242 and / or Fig. 9A and Fig. 9B The barrel 942 of the filter syringe 1030 indicates substantially similar or identical aspects. The filter syringe 1030 may include a plunger assembly 1050 having a first (e.g., distal) body portion 1052a and a second (e.g., proximal) body portion 1052b. The first body portion 1052a may include Fig. 8A and Figure 8B The filter assembly 860, the seal or sealing element 1054, the valve 1058 (e.g., a Luer activated valve, a one-way valve, etc.), and / or a locking feature 1059 configured to engage the locking member 1048 of the filtering syringe 1030. In other embodiments, the first body portion 1052a may include Figures 2A to 2C The filter assembly 260 of the present invention, or any other suitable filter and / or filter assembly. The second body portion 1052b may include a handle 1051, a plunger 1052b1, and / or a tip 1055. The tip 1055 may be configured to couple (e.g., fluidly couple) to a valve 1058 so that the second body portion 1052b may be coupled / connected to the first body portion 1052a.

[0067] In the illustrated embodiment, the second body portion 1052b includes a syringe ("syringe 1052b"), such as a 30cc Luer lock syringe, or any other suitable syringe, including any of the filtration syringes described herein. In these and other embodiments, the syringe 1052b may have an internal volume that is less than, equal to, or greater than the internal volume of the barrel 1042. The tip 1055 of the syringe 1052b may be coupled to the first body portion 1052a such that movement of the syringe 1052b may cause corresponding movement of the first body portion 1052a. In operation, for example, the plunger assembly 1050 (e.g., syringe 1052b) may be pulled relative to the barrel 1042 (e.g., proximally by a user) to generate and / or store a vacuum within the filtration syringe 1030, as previously described with reference to FIG. Figures 1 to 2C Continued movement of the plunger assembly 1050 may cause the locking member 1048 to engage the locking feature 1059 of the first body portion 1052a, for example, to lock the plunger assembly 1050 relative to the barrel assembly 1040 and store a vacuum within the barrel 1042, as previously described with respect to FIG. 2A to FIG. 2C Once a vacuum has been generated and / or stored within the filter syringe 1030, the filter syringe 1030 may be used, for example, as previously described with reference to Figures 1 to 2C Said and / or alone or in combination with reference Figures 3 to 7B Any of the filtered material systems described in detail performs one or more material removal cycles in combination. After the filtering syringe 1030 has been used to perform a material removal cycle, at least a portion of the material drawn in the barrel 1042 can be filtered by actuating the plunger 1052b1 of the syringe 1052b to draw the material (e.g., blood) through the filter assembly 860 and into the syringe 1052b via valve 1058. In at least some embodiments, the syringe 1052b can be configured so that all or substantially all of the blood drawn in the barrel 1042 can be filtered and drawn into the syringe 1052b. Additionally or alternatively, the syringe 1052b can advance toward the material drawn in the barrel 1042 to filter the material in the barrel 1042. In these and other embodiments, because the first body portion 1052a sealingly engages the barrel 1042, as blood is filtered and drawn into the syringe 1052b, proximally withdrawing the plunger 1052b1 can cause corresponding distal movement of the syringe 1052b and the first body portion 1052a within the barrel 1042. Similarly, distal movement of the syringe 1052b can cause corresponding proximal movement of the plunger 1052b1. Once at least a portion of the filtered material is drawn into the syringe 1052b, the syringe 1052b can then be disconnected from the first body portion 1052a, and the filtered material (e.g., blood) within the syringe 1052b can be returned, for example, to the patient.

[0068] Fig.11A is a perspective view of another filtration syringe 1130 constructed in accordance with an embodiment of the present technology. Fig. 11B 1 is an enlarged perspective view of a distal portion 11B of a filter syringe 1130 according to an embodiment of the present technology. Fig.11A and Fig. 11B , the filter syringe 1130 may include FIG. 2A to FIG. 2C Filter syringe 230, FIG. 9A to FIG. 9B Filter syringe 930 and / or Fig.10 The filter syringe 1030 is substantially similar or identical in structure and / or function to at least some aspects, wherein like numbers (e.g., cartridge assembly 1140 vs. Figure 2A The barrel assembly 240, Fig. 9A and Fig. 9B The cartridge assembly 940 and / or Fig.101040) indicates substantially similar or identical aspects. The filtering syringe 1130 may include a barrel assembly 1140, a plunger assembly 1150, and a filtered material subsystem 1170. The filtered material subsystem 1170 may be fluidically coupled to the plunger assembly 1150. The plunger assembly 1150 may include a plunger 1152, which may be slidably received in the barrel assembly 1140. The plunger 1152 may include a filter assembly 1160 and a seal 1154. In the illustrated embodiment, the filter assembly 1160 is at least partially disposed in the plunger 1152 proximal to the first or distal end portion 1153a of the plunger 1152 and distal to the seal 1154. In other embodiments, the filter assembly 1160 may have another suitable position.

[0069] Fig. 11C 1 is a perspective view of a filter assembly 1160 according to an embodiment of the present technology. The filter assembly 1160 may include an annular filter 1162 defining a central space 1164. The annular filter 1162 may be configured to allow a selected fluid (e.g., blood) to flow across the annular filter 1162 toward and / or away from the central space 1164, such as radially outward or inward relative to the longitudinal axis X of the annular filter 1162. In the illustrated embodiment, the annular filter 1162 includes one or more folds or pleats 1166, each of which may increase the surface area of ​​the annular filter 1162 while maintaining a substantially compact form factor. In some aspects of the present technology, it is expected that the increased surface area of ​​the pleats 1166 and / or the annular filter 1162 associated therewith reduces or prevents blockage, obstruction, and / or other reduction of fluid flow through the annular filter 1162, which may increase the number of filtrations performed before the annular filter 1162 is replaced.

[0070] Fig.11D According to the implementation scheme of the present technology Fig. 11B11D-11D in FIG. 11A and 11B . The first end portion 1153a of the plunger 1152 can at least partially define a first or distal chamber portion 1141a on a first (e.g., distal) side of the first end portion 1153a and a second or proximal chamber portion 1141b on a second (e.g., proximal) side of the first end portion 1153a opposite the first side. The most lateral edge 1168 of the first end portion 1153a can have a size (e.g., diameter) that is smaller than a corresponding size (e.g., diameter) of the inner surface 1190 of the barrel 1142, such that the most lateral edge 1168 can be spaced apart from the inner surface 1190 of the barrel 1142 to define a gap or fluid passage 1192 that fluidly couples the first chamber portion 1141a and the second chamber portion 1141b. The annular filter 1162 can be carried by the plunger 1152 and can be at least partially positioned within the second chamber portion 1141b, such as where the central space 1164 of the annular filter 1162 is at least partially aligned with the lumen 1156 of the plunger 1152, and / or such that all or substantially all fluid within the barrel 1142 that enters the lumen 1156 must pass through the annular filter 1162. In the illustrated embodiment, the annular filter 1162 is radially inward from the lateral-most edge 1168, such that the lateral-most edge 1168 overhangs or otherwise extends radially outward relative to the annular filter 1162.

[0071] During the procedure, aspirated material AM, including blood and / or clotted material, may be drawn into the first chamber portion 1141a of the barrel 1142. The plunger 1152 may advance in the first direction D1 and / or may apply a vacuum to the lumen 1156 to cause at least some of the material (e.g., blood) within the first chamber portion 1141a to flow through the gap 1192, into the second chamber portion 1141b, at least partially through the annular filter 1162, into the central space 1164 of the annular filter 1162, and / or into the lumen 1156, such as by Fig.11D1154. The material (e.g., blood) within the lumen 1156 may flow into the filtered material subsystem 1170 and / or be returned to the patient P, including via any of the techniques previously described herein. The gap 1192 between the first end portion 1153a and / or the first chamber portion 1141a and the second chamber portion 1141b is expected to prevent at least a portion of the aspirated material AM (e.g., at least some of the aspirated clotted material) from entering the second chamber portion 1141b and / or otherwise reduce or prevent contact between the aspirated material AM and the annular filter 1162 without or substantially inhibiting the flow of other materials (e.g., blood) between the first chamber portion 1141a and the second chamber portion 1141b. This, in turn, is expected to reduce or prevent blockages or other obstructions to fluid flow through the annular filter 1162. Thus, the first end portion 1153a and / or the gap 1192 can be configured to provide a first filtration stage that inhibits or prevents relatively large substances from entering the second chamber portion 1141b, while the annular filter 1162 can provide a second filtration stage that inhibits or prevents relatively smaller substances from entering the inner cavity 1156.

[0072] Fig. 12A 1 is a perspective view of another filtration syringe plunger assembly 1250 constructed in accordance with embodiments of the present technology. At least some aspects of the plunger assembly 1250 may be substantially similar or identical in structure and / or function to one or more of the plunger assemblies 250, 850, 1050, 1150 previously described herein. For example, the plunger assembly 1250 includes a plunger 1252 ( Fig. 12B ). However, the first or distal end portion 1253a of the plunger 1252 includes one or more holes or apertures 1292.

[0073] Fig. 12B It is along Fig. 11B The section line 12B-12B in Fig. 12A A cross-sectional view of the plunger assembly 1250. Fig. 12B , according to an embodiment of the present technology, the plunger assembly 1250 is shown positioned within the barrel 1242 of the filter syringe 1230. Fig. 12BAs best seen in the figure, the plunger 1252 defines a filter chamber 1294 configured to receive the annular filter 1162 and an inner cavity 1256 that can be fluidly coupled to the filtered material subsystem 1170 and / or the patient. The hole 1292 formed in the first end portion 1253a of the plunger 1252 can be configured to allow fluid communication between the filter chamber 1294 (e.g., the central space 1164 of the annular filter 1162) and the exterior of the plunger 1252 (e.g., the interior of the barrel 1242). More specifically, when the annular filter 1162 is positioned within the filter chamber 1294, each of the holes in the hole 1292 can allow at least some of the aspirated material AM (including, for example, blood and / or other fluids) within the barrel 1242 to flow into the central space 1164 of the annular filter 1162. The proximal end portion 1263 of the filter 1162 can be sealed so that at least some of the aspirated substance AM passing through the apertures 1292 is captured within the central space 1164, for example, and does not pass through the filter 1162 into the filter chamber 1294 and / or the lumen 1256. The distal end portion 1265 of the filter 1162 can be coupled to at least a portion of the first end portion 1253a, for example, to prevent or at least partially prevent the aspirated substance AM from entering the filter chamber 1294 without passing through the central space 1164 of the annular filter 1162.

[0074] During the procedure, the plunger 1252 can be moved relative to the barrel 1242 in the first direction D1 to force at least some of the aspirated substance AM through the various holes in the hole 1292 and / or into the central space 1164. When the aspirated substance AM is collected in the central space 1164, the filter 1162 can separate the blood and / or other fluid contained in the aspirated substance AM from the aspirated substance AM. Because the proximal end portion 1263 and the distal end portion 1265 of the annular filter 1162 are sealed, the blood and / or other fluid can be separated by causing the blood and / or other fluid to flow outward from the central space 1164 across the filter 1162. For example, moving the plunger 1252 in the first direction D1 relative to the barrel 1242 can force blood and / or other fluids across the filter 1162, into the space between the filter 1162 and the filter chamber 1294, and into and / or through at least a portion of the lumen 1256. Blood and / or other fluids within lumen 1256 may flow to filtered material subsystem 1170 and / or back to patient P.

[0075] Therefore, in some aspects of the present technology, a filter syringe can be connected to a catheter subsystem that can be inserted into a patient. The filter syringe can draw material (e.g., clotted material, blood, etc.) from a patient via the catheter subsystem. The filter syringe can include a plunger assembly, and the plunger assembly can include one or more filters. Each filter in the filter can be configured to (i) allow at least a first portion of the drawn material to pass through at least one of the filters, and (ii) prevent at least a second portion of the drawn material from passing through at least one of the filters. In some embodiments, for example, the filter is configured to (i) allow blood to pass through the filter, and (ii) prevent clotted material from passing through the filter, so that the filter can "filter" blood from other materials extracted from the patient. In some embodiments, the filter syringe is fluidically connected to the filtered material subsystem. The filtered material subsystem can include one or more valves and / or pipeline sections, which can fluidly connect the filter syringe to the patient or another suitable fluid (e.g., blood) outflow position. The filtered substance subsystem may (i) capture / receive all or a portion of the first portion of the aspirated substance filtered by the filtering syringe and / or (ii) return / reintroduce all or a portion of the first portion of the aspirated substance into the patient's body.

[0076] Several aspects of the present technology are illustrated in the following examples:

[0077] 1. A filter syringe for treating clotted material from a patient's blood vessel, the filter syringe comprising:

[0078] a barrel defining a chamber configured to receive at least a portion of the clot material and blood from a human patient;

[0079] a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate the first end portion, a port proximate the second end portion, and an inner cavity between and fluidly coupling the filter and the port;

[0080] wherein at least the first end portion of the plunger assembly is insertable into the chamber and slidable relative to the barrel; and

[0081] Wherein the filter is configured to allow at least a portion of the blood received within the chamber to separate from the portion of the clot material and enter the lumen of the plunger assembly.

[0082] 2. The filter syringe of embodiment 1 further comprising a tip configured to fluidly couple the filter syringe to a clot handling system.

[0083] 3. The filtering syringe of embodiment 1 or embodiment 2, wherein the filter has a circular, annular, cylindrical and / or pleated shape.

[0084] 4. The filter syringe of any one of embodiments 1 to 3, wherein the filter has a porosity between about 40 microns and about 200 microns.

[0085] 5. The filtering syringe of any one of embodiments 1 to 4, wherein the filter comprises at least one of polyester, polyamide, and / or a blood compatible material.

[0086] 6. The filter syringe of any one of embodiments 1 to 5, wherein the filter is a first filter having a first porosity, and the filter syringe further comprises a second filter having a second porosity.

[0087] 7. The filter syringe of embodiment 6, wherein the first porosity is different from the first porosity.

[0088] 8. The filter syringe of embodiment 6, wherein the first porosity is the same as the second porosity.

[0089] 9. The filtering syringe of any one of embodiments 6 to 8, wherein the second filter is positioned proximate to the first end portion of the plunger assembly.

[0090] 10. The filter syringe of any one of embodiments 6 to 9 wherein the second filter is spaced apart from the first filter.

[0091] 11. The filtering syringe of any one of embodiments 1 to 10, wherein the port comprises a Luer activated valve.

[0092] 12. A filtering syringe according to any one of embodiments 1 to 11, wherein the first end portion of the plunger assembly is a distal end portion of the plunger assembly, and the second end portion is a proximal end portion of the plunger assembly, wherein the filter is positioned proximally from the distal end portion.

[0093] 13. A filtering syringe according to any one of embodiments 1 to 12, wherein the chamber includes an inner surface, and wherein the first end portion of the plunger assembly is radially spaced from the chamber such that the barrel assembly and the plunger assembly at least partially define: (i) a first chamber portion, the first chamber portion being positioned on a first side of the first end portion of the plunger assembly; (ii) a second chamber portion, the second chamber portion being positioned on a second side of the first end portion of the plunger assembly, the second side being opposite to the first side; and (iii) a gap, the gap fluidly connecting the first chamber portion and the second chamber portion.

[0094] 14. A filtering syringe according to embodiment 13, wherein the filter is positioned in the second chamber portion, wherein the first chamber portion is configured to receive at least the portion of the clotted material from the patient, wherein the gap is configured to at least partially prevent the portion of the clotted material from entering the second chamber portion, and wherein the filter is configured to allow blood within the second chamber portion to enter the inner cavity.

[0095] 15. The filtering syringe of any one of embodiments 1 to 14, wherein the first end portion of the plunger assembly is configured to at least partially prevent contact between the filter and the portion of the clotted material.

[0096] 16. The filtering syringe of any one of embodiments 1 to 15, wherein the plunger assembly defines a filter chamber configured to receive the filter, and wherein the first end portion of the plunger assembly includes one or more holes in fluid communication with the filter chamber.

[0097] 17. A filtering syringe according to embodiment 16, wherein the filter is an annular filter defining a central space, and wherein each of the one or more holes is positioned to direct at least a portion of the clot material and / or the blood received from the patient into the central space.

[0098] 18. A system for intravascular treatment of clotted material from within a blood vessel of a human patient, the system comprising:

[0099] a catheter configured to be positioned within a blood vessel proximate a treatment site of the clot material within the blood vessel;

[0100] A filter syringe configured to generate negative pressure, wherein the filter syringe comprises—

[0101] a tip configured to be fluidly coupled to the catheter to receive at least a portion of the clot material and blood from within the blood vessel via the catheter, and

[0102] A filter assembly includes one or more filters configured to filter the blood from the portion of the clot material.

[0103] 19. The system of embodiment 18, further comprising a filtered substance system fluidly coupled to the filtering syringe and configured to receive at least a portion of the filtered blood.

[0104] 20. The system of embodiment 19, wherein the filtered material system includes a fluid drive component operable to drive the filtered blood to flow through at least a portion of the filtered material system.

[0105] 21. The system of embodiment 20, wherein the filtered material system comprises at least one flow path, and wherein a fluid drive component is operable to drive the filtered blood to flow through the at least one flow path.

[0106] 22. The system of embodiment 21, wherein the at least one flow path is configured to direct fluid flow away from the filter syringe.

[0107] 23. A system according to any one of embodiments 19 to 22, wherein the filtering syringe further includes a valve opposite to the tip, wherein the filtered material system includes (i) a fluid control device fluidly connected to the valve and (ii) a conduit fluidly connected to the fluid control device, and wherein the fluid control device is configured to at least partially prevent filtered blood within the conduit from entering the filtering syringe.

[0108] 24. A method for removing clotted material from a blood vessel of a human patient, the method comprising:

[0109] positioning a distal portion of a catheter proximate to said clotted material within said blood vessel;

[0110] coupling a filtration and pressure generating syringe to the conduit via a fluid control device, wherein (i) opening of the fluid control device fluidly connects the filtration and pressure generating syringe to the conduit, and (ii) closing of the fluid control device fluidly disconnects the filtration and pressure generating syringe from the conduit;

[0111] activating the injector to generate a vacuum when the fluid control device is closed;

[0112] opening the fluid control device to apply the vacuum to the conduit, thereby drawing at least a portion of the clot material into the conduit; and

[0113] Blood is filtered from the portion of the clotted material through a filter of the syringe.

[0114] 25. The method of embodiment 24, wherein filtering the blood comprises moving a plunger of the syringe to move the filter toward the portion of the clotted material.

[0115] 26. The method of Example 24 or Example 25, wherein filtering the blood comprises actuating a fluid drive component of a filtered material system such that the blood flows proximally through the filter toward the fluid drive component.

[0116] 27. A filter syringe for removing a target substance from a human patient, the filter syringe comprising:

[0117] a barrel defining a chamber configured to receive at least a portion of the target substance and a fluid from the human patient;

[0118] a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate the first end portion, a valve proximate the second end portion, and an inner cavity located between and fluidly coupling the filter and the valve;

[0119] wherein at least the first end portion of the plunger assembly is insertable into the chamber and slidable relative to the barrel; and

[0120] wherein the filter is configured to allow receipt of the fluid within the chamber

[0121] At least a portion of the fluid passes through the filter and enters the lumen of the plunger assembly. 28. The filtering syringe of embodiment 27, wherein the fluid comprises blood.

[0122] 29. The filtering syringe of Example 27 or Example 28, wherein the target substance comprises clotted material.

[0123] 30. A filter syringe for use in treating a human patient, the filter syringe comprising:

[0124] a barrel defining a chamber configured to receive a first substance and a second substance from the human patient;

[0125] a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate the first end portion, a valve proximate the second end portion, and an inner cavity located between and fluidly coupling the filter and the valve;

[0126] wherein at least the first end portion of the plunger assembly is insertable into the chamber and slidable relative to the barrel; and

[0127] wherein the filter is configured to (i) allow at least a portion of the first substance received in the chamber to pass through the filter and enter the inner cavity of the plunger assembly, and (ii) prevent at least a portion of the second substance received in the chamber from passing through the filter.

[0128] 31. The filtering syringe of embodiment 30, wherein the first substance comprises blood.

[0129] 32. The filter syringe of embodiment 30 or embodiment 31, wherein the second substance comprises a clot substance.

[0130] 33. A filter syringe for use in treating a human patient, the filter syringe comprising:

[0131] a barrel defining a chamber configured to receive a first substance and a second substance from the human patient; and

[0132] a plunger assembly comprising a first body portion and a second body portion, wherein the first body portion comprises a filter and a valve, and wherein the second body portion defines an internal chamber and is removably coupled to the first body portion via the valve;

[0133] wherein at least a portion of the first body portion and the second body portion are insertable into the chamber and slidable relative to the barrel; and

[0134] Wherein the filter is configured to allow at least a portion of the first substance received within the chamber to pass through the filter and into the interior chamber of the second body portion.

[0135] 34. The filtering syringe of embodiment 33, wherein the second body portion comprises a syringe comprising a plunger operable to draw at least a portion of the first substance within the chamber through the filter and into the internal chamber of the syringe.

[0136] 35. The filtration syringe of embodiment 34, wherein the syringe includes a tip, and wherein the valve of the first body portion is configured to cooperatively engage the tip of the syringe to fluidly couple the chamber of the barrel to the internal chamber of the syringe.

[0137] 36. The filtering syringe of any one of embodiments 33 to 35, wherein the first substance comprises blood.

[0138] 37. The filter syringe of any one of embodiments 33 to 36, wherein the second substance comprises a clot substance.

[0139] The above detailed description of the embodiments of the present technology is not intended to be exhaustive or to limit the present technology to the precise form disclosed above. Although specific embodiments and examples of the present technology are described above for illustrative purposes, those skilled in the relevant art will recognize that various equivalent modifications can be made within the scope of the present technology. For example, although the steps are given in a given order, alternative embodiments can perform the steps in a different order. The various embodiments described herein can also be combined to provide other embodiments.

[0140] From the above, it should be understood that the specific embodiments of the technology have been described herein for illustrative purposes, but well-known structures and functions have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the technology. Where the context permits, singular or plural terms may also include plural or singular terms, respectively.

[0141] In addition, unless the word "or" is expressly limited to mean only a single item in a list involving two or more items that excludes other items, the use of "or" in such a list should be interpreted as including (a) any single item in the list, (b) all items in the list, or (c) any combination of items in the list. In addition, the term "comprising" refers to at least including the mentioned features from beginning to end, so that any greater number of the same features and / or other types of features are not excluded. It should also be understood that specific embodiments have been described here for illustrative purposes, but various modifications can be made without departing from the present technology. In addition, although the advantages associated with certain embodiments of the present technology have been described in the context of these embodiments, other embodiments may also exhibit such advantages, and not all embodiments must exhibit such advantages to belong to the scope of the present technology. Therefore, the present disclosure and related technologies may include other embodiments not explicitly shown or described herein.

Claims

1. A filter syringe for treating clotted material from a patient's blood vessel, the filter syringe comprising: a barrel defining a chamber configured to receive at least a portion of the clot material and blood from the patient; and a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate the first end portion, a port proximate the second end portion, and an inner cavity between and fluidly coupling the filter and the port; wherein at least the first end portion of the plunger assembly is insertable into the chamber and slidable relative to the barrel; and Wherein the filter is configured to allow at least a portion of the blood received within the chamber to separate from the portion of the clot material and enter the lumen of the plunger assembly.

2. The filter syringe of claim 1, further comprising a tip configured to fluidly couple the filter syringe to a clot management system.

3. The filtering syringe according to claim 1, wherein the filter has a circular, annular, cylindrical and / or pleated shape.

4. The filter syringe of claim 1, wherein the filter has a porosity between about 40 microns and about 200 microns.

5. The filtering syringe of claim 1, wherein the filter comprises at least one of polyester, polyamide, and / or a blood-compatible material.

6. The filter syringe of claim 1, wherein the filter is a first filter having a first porosity, the filter syringe further comprising a second filter having a second porosity.

7. The filter syringe of claim 6, wherein the first porosity is different from the first porosity.

8. The filter syringe of claim 6, wherein the first porosity is the same as the second porosity.

9. The filtering syringe of claim 6, wherein the second filter is positioned proximate the first end portion of the plunger assembly.

10. The filtering syringe of claim 6, wherein the second filter is spaced apart from the first filter.

11. The filtering syringe of claim 1 , wherein the port comprises a Luer activated valve.

12. The filtering syringe of claim 1, wherein the first end portion of the plunger assembly is a distal end portion of the plunger assembly and the second end portion is a proximal end portion of the plunger assembly, wherein the filter is positioned proximally from the distal end portion.

13. The filtration syringe of claim 1 , wherein the chamber includes an inner surface, and wherein the first end portion of the plunger assembly is radially spaced from the chamber such that the barrel assembly and the plunger assembly at least partially define: (i) a first chamber portion, the first chamber portion being positioned on a first side of the first end portion of the plunger assembly; (ii) a second chamber portion positioned on a second side of the first end portion of the plunger assembly, the second side being opposite the first side; and (iii) a gap fluidly coupling the first chamber portion and the second chamber portion.

14. A filtering syringe according to claim 13, wherein the filter is positioned in the second chamber portion, wherein the first chamber portion is configured to receive at least the portion of the clotted material from the patient, wherein the gap is configured to at least partially prevent the portion of the clotted material from entering the second chamber portion, and wherein the filter is configured to allow blood within the second chamber portion to enter the inner cavity.

15. The filtering syringe of claim 1, wherein the first end portion of the plunger assembly is configured to at least partially prevent contact between the filter and the portion of the clotted material.

16. The filtering syringe of claim 1, wherein the plunger assembly defines a filter chamber configured to receive the filter, and wherein the first end portion of the plunger assembly includes one or more apertures in fluid communication with the filter chamber.

17. A filtering syringe according to claim 16, wherein the filter is an annular filter defining a central space, and wherein each of the one or more holes is positioned to direct at least a portion of the clot material and / or the blood received from the patient into the central space.

18. A system for intravascular treatment of clotted material from within a blood vessel of a human patient, the system comprising: a catheter configured to be positioned within a blood vessel proximate a treatment site of the clot material within the blood vessel; and A filter syringe configured to generate negative pressure, wherein the filter syringe comprises— a tip configured to be fluidly coupled to the catheter to receive at least a portion of the clot material and blood from within the blood vessel via the catheter, and A filter assembly includes one or more filters configured to filter the blood from the portion of the clot material.

19. The system of claim 18, further comprising a filtered substance system fluidly coupled to the filtering syringe and configured to receive at least a portion of the filtered blood.

20. The system of claim 19, wherein the filtered material system includes a fluid drive component operable to drive the filtered blood to flow through at least a portion of the filtered material system.

21. The system of claim 20, wherein the filtered material system comprises at least one flow path, and wherein a fluid drive component is operable to drive the filtered blood to flow through the at least one flow path.

22. The system of claim 21, wherein the at least one flow path is configured to direct fluid flow away from the filter syringe.

23. The system of claim 19, wherein the filtering syringe further comprises a valve opposite the tip, wherein the filtered material system comprises (i) a fluid control device fluidically connected to the valve and (ii) a conduit fluidly connected to the fluid control device, and wherein the fluid control device is configured to at least partially prevent filtered blood within the conduit from entering the filtering syringe.

24. A method for removing clotted material from a blood vessel of a human patient, the method comprising: positioning a distal portion of a catheter proximate to said clotted material within said blood vessel; coupling a filtration and pressure generating syringe to the conduit via a fluid control device, wherein (i) opening of the fluid control device fluidly connects the filtration and pressure generating syringe to the conduit, and (ii) closing of the fluid control device fluidly disconnects the filtration and pressure generating syringe from the conduit; activating the injector to generate a vacuum when the fluid control device is closed; opening the fluid control device to apply the vacuum to the conduit, thereby drawing at least a portion of the clot material into the conduit; as well as Blood is filtered from the portion of the clotted material through a filter of the syringe.

25. The method of claim 24, wherein filtering the blood comprises moving a plunger of the syringe to move the filter toward the portion of the clotted material.

26. The method of claim 24, wherein filtering the blood comprises actuating a fluid drive component of a filtered material system to cause the blood to flow proximally through the filter toward the fluid drive component.

27. A filter syringe for removing a target substance from a human patient, the filter syringe comprising: a barrel defining a chamber configured to receive at least a portion of the target substance and a fluid from the human patient; and a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate the first end portion, a valve proximate the second end portion, and an inner cavity located between and fluidly coupling the filter and the valve; wherein at least the first end portion of the plunger assembly is insertable into the chamber and slidable relative to the barrel; and Wherein the filter is configured to allow at least a portion of the fluid received within the chamber to pass through the filter and enter the inner cavity of the plunger assembly.

28. The filtering syringe of claim 27, wherein the fluid comprises blood.

29. The filtering syringe of claim 27, wherein the target substance comprises clotted material.

30. A filter syringe for use in treating a human patient, the filter syringe comprising: a barrel defining a chamber configured to receive a first substance and a second substance from the human patient; and a plunger assembly having a first end portion and a second end portion opposite the first end portion, wherein the plunger assembly includes a filter proximate the first end portion, a valve proximate the second end portion, and an inner cavity located between and fluidly coupling the filter and the valve; wherein at least the first end portion of the plunger assembly is insertable into the chamber and slidable relative to the barrel; and wherein the filter is configured to (i) allow at least a portion of the first substance received in the chamber to pass through the filter and enter the inner cavity of the plunger assembly, and (ii) prevent at least a portion of the second substance received in the chamber from passing through the filter.

31. The filtering syringe of claim 30, wherein the first substance comprises blood.

32. The filtering syringe of claim 30, wherein the second substance comprises a clotted substance.

33. A filter syringe for use in treating a human patient, the filter syringe comprising: a barrel defining a chamber configured to receive a first substance and a second substance from the human patient; and a plunger assembly comprising a first body portion and a second body portion, wherein the first body portion comprises a filter and a valve, and wherein the second body portion defines an internal chamber and is removably coupled to the first body portion via the valve; wherein at least a portion of the first body portion and the second body portion are insertable into the chamber and slidable relative to the barrel; and Wherein the filter is configured to allow at least a portion of the first substance received within the chamber to pass through the filter and into the interior chamber of the second body portion.

34. The filtering syringe of claim 33, wherein the second body portion comprises a syringe including a plunger operable to draw at least a portion of the first substance within the chamber through the filter and into the interior chamber of the syringe.

35. The filtration syringe of claim 34, wherein the syringe includes a tip, and wherein the valve of the first body portion is configured to matingly engage the tip of the syringe to fluidly couple the chamber of the barrel to the interior chamber of the syringe.

36. The filtering syringe of claim 33, wherein the first substance comprises blood.

37. The filtering syringe of claim 33, wherein the second substance comprises clot.

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