Scutellaria baicalensis root extract-containing oil-controlling and acne-removing composition with synergistic interaction as well as preparation method and application thereof

Abstract

The invention relates to the technical field of cosmetics, and discloses a radix scutellariae root extract-containing synergistic oil control and acne removal composition which comprises the following components in parts by mass: 0.05-1 part of a radix scutellariae root extract, 0.3-2 parts of capryloyl glycine and 0.04-1.5 parts of an antioxidant, the composition has the effects of controlling oil, mildly removing acnes, resisting inflammation and relieving, and can regulate the micro-ecological balance of skin, so that the acne removal effect is improved. The growth of beneficial bacteria can be promoted, the growth of harmful bacteria can be inhibited, and the effects of improving the skin barrier and enhancing the skin immunity are achieved; the scutellaria baicalensis root extract in the composition contains 80% of baicalin active ingredients, the ingredients are simple and clear, the safety risk is low, and the composition can be used for a long time after being added into cosmetic products.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a synergistic oil-controlling and acne-removing composition containing a scutellaria baicalenhancing root extract, a preparation method and an application thereof. Background Art

[0002] Acne is a common chronic inflammatory disease. Because it is prone to occur during adolescence, it is often called acne. It mainly occurs in parts of the face and back where sebum secretion is high. The symptoms are mainly acne, papules, pustules, etc. Acne is a common skin problem among teenagers. Studies have found that more than 95% of people will have acne to varying degrees. After teenagers enter puberty, their bodies and organs begin to develop and gradually mature. With the vigorous secretion of sex hormones, the sebaceous glands begin to become active. The density of facial sebaceous glands is high and oil is produced. Excessive sebum and cell debris clog the pores, causing excessive keratinization at the hair follicles, followed by accumulation of keratin and sebum to form acne. If you do not pay attention to maintenance at this time, it will lead to an imbalance of local flora and inflammation, destroying the microecological balance of the skin, which may further develop into papules and pustules. Therefore, excessive secretion of sebaceous glands and imbalance of skin microecology are prerequisites for the occurrence of acne.

[0003] In clinical practice, acne is generally treated with topical retinoic acid ointments and oral antibiotics, but long-term use of retinoic acid can cause skin problems such as desquamation, dryness, and itching, and does not repair the skin barrier. The oil-control and acne-removing products on the market are mainly for adults, and generally add acidic substances to achieve acne-removing effects, such as salicylic acid and fruit acid; such products are highly irritating and can cause secondary damage to the skin if used improperly. The mechanism of acne in adolescents is different from that in adults. The occurrence of acne in adolescents is more caused by hormone regulation and is a long-term process. The occurrence of acne in adults is mainly due to external influences such as environment, diet, and mental stress. The skin of adolescents is in a stage of perfect development and is more sensitive. The use of highly acidic skin care products may cause skin damage and aggravate inflammation. Therefore, adult oil-control and acne-removing products are not suitable for adolescents.

[0004] For example, the oil-control and acne-removing composition and its application disclosed in publication number CN114366692A mainly utilizes hyaluronic acid, zinc chloride and salicylic acid to synergistically promote the effect of oil-control and acne-removing; another example is the acne-removing composition disclosed in publication number CN111714404B and its preparation method and application. The composition in this technical solution includes 4-hydroxyethylpiperazineethanesulfonic acid, salicylic acid derivatives, madecassoside and active zinc. The ingredients in the composition have the effect of oil-control and acne-removing, but the composition is only for adult skin. The composition uses salicylic acid as the main acne-removing effective ingredient, but salicylic acid has low applicability to adolescent skin. In addition, the existing acne-removing products have a low time effect, and have a weak effect on the skin of adolescents with recurrent acne, and cannot strengthen the skin barrier and maintain the balance of skin microecology for a long time. Summary of the invention

[0005] In order to overcome the problem of lack of oil-controlling and acne-removing skin care products suitable for teenagers under the existing technical conditions, the present invention provides a synergistic oil-controlling and acne-removing composition containing scutellaria root extract, the composition has the effects of oil control, mild acne removal, anti-inflammatory and soothing, and can regulate the microecological balance of the skin, promote the growth of beneficial bacteria and inhibit the growth of harmful bacteria, play a role in improving the skin barrier and strengthening the skin immunity; and the scutellaria root extract in the composition contains 80% of baicalin active ingredients, the composition is simple and clear, the safety risk is low, and it can be added to cosmetic products for long-term use.

[0006] The specific technical scheme of the present invention is: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.05-1 part of Scutellaria baicalensis root extract, 0.3-2 parts of capryloyl glycine, Antioxidant 0.04-1.5 parts.

[0007] Preferably, the antioxidant is one or both of sodium sulfite and sodium pyrosulfite.

[0008] Preferably, the baicalin content in the Scutellaria baicalensis root extract is ≥80%.

[0009] The invention provides a synergistic oil-controlling and acne-removing composition containing a scutellaria root extract. The composition comprises a scutellaria root extract and capryloyl glycine. The composition has the effects of mild acne removal, oil control, and anti-inflammatory and soothing effects. The composition can also regulate the microecological balance of the skin, promote the growth of beneficial bacteria and inhibit the growth of harmful bacteria, enhance the skin barrier, and strengthen the skin immunity. The composition has simple ingredients, low safety risks, and is non-irritating, and can be suitable for the skin of adolescents.

[0010] The octanoyl glycine in the composition is synthesized from octanoic acid and glycine, and is the main component of dermal structural proteins. The octanoyl glycine can maintain the balance of the pH value of the skin by providing free carboxyl groups, and the octanoyl glycine has extremely high antibacterial activity against harmful bacteria on the skin; the scutellaria root extract in the composition is a yellow powder obtained by drying the root of scutellaria, which is rich in flavonoids, such as baicalin and baicalein, and has significant biological activities on the skin, such as oil control, anti-inflammatory, antibacterial, immunomodulatory, antioxidant, and anti-allergic effects; the present application also finds that the antibacterial activity of the composition of the present application against harmful bacteria on the skin (Propionibacterium acnes, Staphylococcus aureus, and Candida albicans) is significantly improved, which is significantly higher than the technical solutions of using octanoyl glycine alone and using scutellaria root extract alone. In addition, the inhibitory activity of the composition against beneficial bacteria on the skin (Staphylococcus epidermidis, Bifidobacterium) is significantly reduced, which is significantly lower than the technical solutions of using octanoyl glycine alone and using scutellaria root extract alone.

[0011] The content of active substances in the root extract of Scutellaria baicalensis is high. In actual application, it is found that the root extract of Scutellaria baicalensis is easily exposed to light, oxidized and discolored, and the activity gradually decreases with the change of color. Therefore, in order to better protect the active ingredients in the root extract of Scutellaria baicalensis, sodium metabisulfite and / or sodium sulfite are used as antioxidants, which can play a synergistic role in antiseptic.

[0012] A method for preparing the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract comprises adding capryloyl glycine into water, heating until dissolved and adjusting the pH, and then adding scutellaria root extract and antioxidants after cooling, mixing evenly and adjusting the pH to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract.

[0013] Preferably, the heating temperature is 75-85°C, and the cooling temperature is 35-40°C.

[0014] Preferably, the pH is adjusted by using a pH regulator, and the pH regulator is one or more of arginine, aminomethyl propanol, sodium hydroxide, triethanolamine, and citric acid.

[0015] A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract is used in cosmetics. Cosmetics are made from cosmetic raw materials, wherein the cosmetic raw materials include the synergistic oil-controlling and acne-removing composition containing a scutellaria root extract.

[0016] Preferably, the cosmetic raw materials further include one or two of solvents, moisturizers, preservatives, emollients, emulsifiers, and surfactants, and the added amount of the synergistic oil-controlling and anti-acne composition containing Scutellaria baicalenhancing root extract is 0.4-2.5%.

[0017] Preferably, the cosmetics are rinse-off products and leave-on products.

[0018] Preferably, the pH of the cosmetic is 5.0-7.0.

[0019] Compared with the prior art, this application has the following technical effects: The present invention provides a synergistic oil-control and acne-removing composition containing a scutellaria root extract, which can inhibit excessive oil secretion of sebaceous glands, reduce oil secretion from the source, and reduce the probability of acne; the composition synergistically inhibits the excessive reproduction of harmful bacteria such as Propionibacterium acnes and Staphylococcus aureus, and can provide nutrients for the skin's Staphylococcus epidermidis and Bifidobacterium beneficial bacteria to promote their reproduction, so as to maintain the microecological balance of the skin. This patent does not simply inhibit fungi or bacteria, but emphasizes the balancing effect of microbial flora; the scutellaria root extract in the composition can inhibit the expression of inflammatory factors IL-6, PGE2 and TNF-α, thereby making up for the deficiency of capryloyl glycine to relieve skin inflammation and strengthen the skin barrier, and the composition is different from the strong irritation of organic acids such as retinoic acid and salicylic acid, and can play a role in gentle oil control and acne removal. DETAILED DESCRIPTION

[0020] The present invention will be further described below in conjunction with the embodiments.

[0021] Embodiment 1: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract (containing baicalin ≥ 80%), 0.75 part of capryloyl glycine, and an antioxidant (0.1 part of sodium pyrosulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.75wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.1wt% of scutellaria root extract, 0.1wt% of sodium pyrosulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0022] Embodiment 2: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract (containing baicalin ≥ 80%), 0.75 part of capryloyl glycine, and an antioxidant (0.05 part of sodium pyrosulfite and 0.05 part of sodium sulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.75wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.1wt% of scutellaria root extract, 0.05wt% of sodium pyrosulfite, 0.05wt% of sodium sulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0023] Embodiment 3: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract (containing baicalin ≥ 80%), 1 part of capryloyl glycine, and an antioxidant (0.1 part of sodium sulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 1wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.1wt% of scutellaria root extract, 0.1wt% of sodium sulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0024] Embodiment 4: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.15 parts of a scutellaria root extract (containing baicalin ≥ 80%), 0.5 parts of capryloyl glycine, and an antioxidant (0.12 parts of sodium pyrosulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.5wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.15wt% of scutellaria root extract, 0.12wt% of sodium pyrosulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0025] Embodiment 5: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.15 parts of a scutellaria root extract (containing baicalin ≥ 80%), 0.75 parts of capryloyl glycine, and an antioxidant (0.06 parts of sodium pyrosulfite and 0.06 parts of sodium sulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.75wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.15wt% of scutellaria root extract, 0.06wt% of sodium pyrosulfite, 0.06wt% of sodium sulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0026] Embodiment 6: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.15 parts of a scutellaria root extract (containing baicalin ≥ 80%), 1 part of capryloyl glycine, and an antioxidant (0.12 parts of sodium sulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 1wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.15wt% of scutellaria root extract, 0.12wt% of sodium sulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0027] Embodiment 7: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.2 parts of a scutellaria root extract (containing baicalin ≥ 80%), 0.5 parts of capryloyl glycine, and an antioxidant (0.3 parts of sodium pyrosulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.5wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.2wt% of scutellaria root extract, 0.3wt% of sodium pyrosulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0028] Embodiment 8: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.2 parts of a scutellaria root extract (containing baicalin ≥ 80%), 0.75 parts of capryloyl glycine, and an antioxidant (0.15 parts of sodium pyrosulfite and 0.15 parts of sodium sulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.75wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.2wt% of scutellaria root extract, 0.15wt% of sodium pyrosulfite, 0.15wt% of sodium sulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0029] Embodiment 9: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.2 parts of a scutellaria root extract (containing baicalin ≥ 80%), 1 part of capryloyl glycine, and an antioxidant (0.3 parts of sodium sulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing scutellaria root extract in cleansing bubbles, comprising the following steps: adding 15wt% of sodium lauroyl glutamate, 3wt% of disodium cocoyl glutamate, 3wt% of lauryl glucoside, 4wt% of glycerol and 0.5wt% of p-hydroxyacetophenone to water to prepare phase A; heating phase A to 80°C, adding 0.75wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.2wt% of scutellaria root extract, 0.3wt% of sodium sulfite and 0.5wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to prepare cleansing bubbles.

[0030] Embodiment 10: A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, comprising, by weight: 0.1 part of a scutellaria root extract (containing baicalin ≥ 80%), 0.75 part of capryloyl glycine, and an antioxidant (0.1 part of sodium pyrosulfite); A preparation method of the above-mentioned synergistic oil-controlling and acne-removing composition containing scutellaria root extract, comprising the following steps: adding capryloyl glycine to deionized water at 75-85° C., then adding a pH adjuster to adjust the pH to 7.5-8.0, stirring evenly, then cooling to 35-40° C., then adding scutellaria root extract and an antioxidant to adjust the pH to 5.5-6.5 to prepare the synergistic oil-controlling and acne-removing composition containing scutellaria root extract; The invention discloses an application of the synergistic oil-controlling and acne-removing composition containing the scutellaria root extract in a gel, comprising the following steps: dispersing 1wt% of polyacrylate cross-linked polymer-6 in water, adding 8wt% of glycerol and stirring evenly to form phase A; heating phase A to 80°C, adding 0.75wt% of capryloyl glycine and stirring until dissolved, adding arginine to adjust the pH to 8.0, cooling to 40°C after complete dissolution, adding 0.1wt% of scutellaria root extract, 0.1wt% of sodium pyrosulfite and 1wt% of 1,2-hexanediol and stirring until dissolved, and adding citric acid to adjust the pH to 6.0 to form a gel.

[0031] Comparative Example 1: Compared with the examples, no capryloyl glycine was added in Comparative Example 1.

[0032] Comparative Example 2: Compared with the embodiment, in Comparative Example 2, no Scutellaria baicalensis root extract was added.

[0033] Comparative Example 3: Compared with the examples, no antioxidant was added in Comparative Example 3.

[0034] Comparative Example 4: Compared with the embodiment, in Comparative Example 4, a salicylic acid coating is used instead of the synergistic oil-controlling and anti-acne composition containing Scutellaria baicalensis root extract. The preparation method of the salicylic acid coating is as follows: salicylic acid is coated with dextrin to prepare 50% salicylic acid, the salicylic acid coating is added to water, a pH adjuster is added to adjust the pH to 5.5, and the mixture is stirred evenly.

[0035] Comparative Example 5: Compared with the examples, the synergistic oil-controlling and anti-acne composition containing the scutellaria baicalensis root extract was not added in Comparative Example 5.

[0036] Comparative Example 6: Compared with the embodiment, the final pH of the product in Comparative Example 6 is 4.8.

[0037] Test example 1: The harmful bacteria inhibition rate of the synergistic oil-control and acne-removing compositions containing the scutellaria root extract prepared in the above Examples 1 to 9 and Comparative Examples 1 to 2 was tested. The harmful bacteria inhibition experiment was carried out in accordance with "WS / T650-2019 Antibacterial and Antibacterial Effect Evaluation Method 5.1.1 Suspension Quantitative Antibacterial Test". The test steps include: taking a 24h fresh slant culture of the test bacteria, washing it with PBS, and diluting it with PBS to about 5.0×10 5 CFU / mL~4.5×10 6 CFU / mL bacterial suspension is ready for use. Take a sterile test tube, add 5.0mL of sample first (use stock solution or dilution according to the instructions), place it in 20℃±1℃ water for 5 minutes, then add 0.1mL of test bacterial suspension, mix quickly and start timing immediately. Wait for the test bacteria and sample to interact with each other for the time specified in the instructions, then take 1.0mL of the test bacteria and sample mixture to inoculate 2 plates respectively, and pour the culture medium. When the amount of bacteria cannot be counted, make a 10-fold serial dilution with PBS, select the appropriate dilution and take 1.0mL to inoculate 2 plates respectively, and count the live bacteria culture. At the same time, use PBS instead of the sample to conduct a parallel test as a positive control;. The number of colonies recovered in the positive control is 1.0×10 4 CFU / mL~9.0×10 4 CFU / mL; PBS and culture medium from the same batch were used as negative controls. All test samples and control samples were cultured at 36℃±1℃, and the bacterial propagules were cultured for 48 hours to observe the final results. The test was repeated 3 times, and the inhibition rate was calculated; the experimental bacteria were Propionibacterium acnes, Staphylococcus aureus and Candida albicans; the results were judged as follows: the inhibition rate was >50%~90%, which was judged to have an antibacterial effect; the inhibition rate was >90%, which was judged to have a strong antibacterial effect; the test results are shown in Table 1; Table 1 Inhibition rate of harmful bacteria Propionibacterium acnes inhibition rate (%) Staphylococcus aureus inhibition rate (%) Candida albicans inhibition rate (%) Example 1 >99.99 >99.99 >99.99 Example 2 >99.99 >99.99 >99.99 Example 3 >99.99 >99.99 >99.99 Example 4 >99.99 >99.99 >99.99 Example 5 >99.99 >99.99 >99.99 Example 6 >99.99 >99.99 >99.99 Example 7 >99.99 >99.99 >99.99 Example 8 >99.99 >99.99 >99.99 Example 9 >99.99 >99.99 >99.99 Comparative Example 1 40.83 10.42 9.20 Comparative Example 2 54.31 60.77 50.79 As shown in Table 1, the compositions prepared in Examples 1 to 9 have excellent antibacterial effects on Propionibacterium acnes, Staphylococcus aureus and Candida albicans, and the antibacterial rates all reach 99.99%. No capryloyl glycine is added in Comparative Example 1, and no scutellaria root extract is added in Comparative Example 2. Compared with Comparative Examples 1 and 2, the antibacterial effects of Examples 1 to 9 on Propionibacterium acnes, Staphylococcus aureus and Candida albicans are significantly higher than those of Comparative Examples 1 and 2. The above results show that the synergistic oil-control and acne-removing composition containing scutellaria root extract has a significant inhibitory effect on skin harmful bacteria, and the capryloyl glycine and scutellaria root extract in the composition have a synergistic effect. The use of the combination of the two can significantly inhibit the growth of harmful bacteria such as Propionibacterium acnes, Staphylococcus aureus and Candida albicans.

[0038] Test example 2: The beneficial bacteria effect of the synergistic oil-control and anti-acne compositions containing the scutellaria root extract prepared in Examples 1 to 9 and Comparative Examples 1 to 2 was tested. The testing method was as follows: Staphylococcus epidermidis, Bifidobacterium and Propionibacterium acnes were inoculated simultaneously in LNA agar culture media containing Example 1, Comparative Examples 1 and 5, respectively; after culturing for 24 hours, the reproduction of the above-mentioned flora was evaluated. The test results are shown in Table 2; Table 2 Probiotic reproduction effect As shown in Table 2, the compositions prepared in Examples 1 to 9 have a technical effect of promoting the growth and reproduction of beneficial bacteria (Staphylococcus epidermidis and Bifidobacterium), and have a technical effect of inhibiting the growth and reproduction of harmful bacteria (Propionibacterium acnes). In Comparative Example 1, no capryloyl glycine was added, and Comparative Example 1 had an inhibitory effect on Staphylococcus epidermidis and Propionibacterium acnes, and had a weaker promoting effect on Bifidobacterium. In Comparative Example 2, no Scutellaria baicalensis root extract was added, and Comparative Example 2 had an inhibitory effect on Staphylococcus epidermidis, Bifidobacterium and Propionibacterium acnes. The above results show that capryloyl glycine has an inhibitory effect on both beneficial bacteria and harmful bacteria on the skin. When only capryloyl glycine is used, although Although it can inhibit the growth of harmful bacteria on the skin, it will also inhibit the growth of beneficial bacteria on the skin, destroy the skin microenvironment, and cause damage to the skin barrier. Although the use of only scutellaria root extract has a promoting effect on some beneficial bacteria (bifidobacterium), it also has a certain inhibitory effect on some beneficial bacteria (Staphylococcus epidermidis), resulting in the inhibition of the skin microecological environment. The combined use of capryloyl glycine and scutellaria root extract in the present invention can significantly improve the growth of beneficial bacteria (Staphylococcus epidermidis, bifidobacterium) and significantly inhibit the growth and reproduction of harmful bacteria (Propionibacterium acnes), can improve the activity of the skin microecology, and enhance the effect of the skin microecology on the skin barrier.

[0039] Test Example 3: The synergistic oil-control and acne-removing compositions containing scutellaria baicalenhancing root extracts prepared in Examples 1 to 9 and Comparative Examples 1 to 2 were tested for sebaceous gland cell oil content; the testing steps included: inoculating the sebaceous gland cell SZ95 strain suspension extracted from the tissue sample into a 96-well cell culture plate, and culturing for 18-24 hours until the cells reached 80% fusion. The original culture medium in the well was discarded, and 50 μL of the sample solution was added to each well in turn. During the experiment, a blank control (Group B), a model (Group M), and a positive control (PC) were set up. The positive control was isotretinoin, the experimental test group was Examples 1-9 and Comparative Examples 1-6, and the sample concentration was 10 -4%. After adding the sample, the model group added 50 μL of cell culture medium, and the other groups added 50 μL of cell culture medium containing linoleic acid. After adding the sample, the culture plate was placed in an incubator and cultured for (24±1) h. After the culture was completed, it was washed once with PBS, 100 μL of Nile red was added to each well, and the reaction was carried out at 37°C in the dark for 20 min, and the fluorescence intensity was detected at Ex / Em=485nm / 565nm; In the formula, MEI 样品 、MEI B 、MEI M are the mean fluorescence intensity of the sample group, group B, and group M, respectively; The test results are shown in Table 3; Table 3 Detection results of oil content in sebaceous gland cells As shown in Table 3, the compositions in Examples 1 to 9 can achieve a maximum oil inhibition rate of 28.89% in SZ95 cells, having excellent oil inhibition effect. No capryloyl glycine was added in Comparative Example 1, and no scutellaria root extract was added in Comparative Example 2. The oil inhibition rates of Examples 1 to 9 were significantly improved compared with Comparative Example 1 and Comparative Example 2. The above results indicate that the synergistic oil control and acne removal composition containing scutellaria root extract provided by the present invention has an excellent oil inhibition effect, and the capryloyl glycine and scutellaria root extract in the composition have a synergistic effect. The use of the combination of the two can significantly improve the oil inhibition rate of SZ95 cells.

[0040] Test example 4: The stability of the products prepared in Examples 1 to 10, Comparative Examples 3 and 6 was tested. The samples were placed at -10°C, 5°C, 25°C and 45°C for 3 months for stability observation to determine the stability of the product. If there was no precipitation instability and no obvious color change, the stability passed. The test standard was: A means no precipitation problem and no obvious color change; B means no precipitation problem but obvious color change visible to the naked eye; C means no obvious color change but precipitation is visible to the naked eye. The test results are shown in Table 4. Table 4 Product stability test results -10℃ 5℃ 25℃ 45℃ Example 1 A A A A Example 2 A A A A Example 3 A A A A Example 4 A A A A Example 5 A A A A Example 6 A A A A Example 7 A A A A Example 8 A A A A Example 9 A A A A Example 10 A A A A Comparative Example 3 A A B B Comparative Example 6 C C C C As shown in Table 4, the products prepared in Examples 1 to 10 changed color when stored at -10°C, 5°C, 25°C and 45°C for 3 months. In Comparative Example 3, no antioxidant was added and the product color did not change after 3 months of low-temperature storage, but produced visible changes at room temperature and high temperature. Comparative Example 4 is a product with a pH of 4.8. Although the product color did not change after being stored at -10°C, 5°C, 25°C and 45°C for 3 months, visible precipitation occurred. The above results show that the product prepared by the present invention has excellent stability after storage at low temperature, room temperature and high temperature. The product without adding a stabilizer has poor antioxidant properties and is easy to change color when stored at room temperature and high temperature. In addition, storage of the product under acidic conditions below 5.0 will cause the Scutellaria baicalensis root composition in the product to precipitate, resulting in the precipitation of the product's effective components and reducing the product effect.

[0041] Test example 5: The oil control, acne removal and soothing effects of the products prepared in Examples 1 and 10 were tested. The test method was as follows: "T / CNMIA 0012-2020 Clinical Evaluation Standards for Acne-Removing Functional Skin Care Products" and "T / ZHCA 002-2018 Test Method for Oil Control Efficacy of Cosmetics" were used to measure the skin oil content, a* value, acne scar area ratio, acne height and acne volume of 30 subjects aged 18 to 25 before and after using the test samples, and dermatologists conducted clinical evaluations and subjects conducted self-evaluations to verify the effectiveness of the samples in removing acne, controlling oil, improving redness, and fading acne scars. The skin oil content was tested using the skin oil test probe Sebumeter on the forehead at 0d and 28d of using the product. The smaller the test value, the lower the skin oil content; the facial image analysis system Visia 7 was used to analyze the a* value and the acne scar area ratio, and the whole face skin was tested at 0d and 28d of using the product; the smaller the value, the smaller the reddened area of ​​the skin and the smaller the acne scar area ratio; the acne height and acne volume were measured using the skin fast optical imaging system PRIMOS CR tested the acne areas on the 0th and 3rd day of using the product, and the test results are shown in Table 5; Table 5 Test results of the products' oil control, acne removal and soothing effects on human body As shown in Table 5, the results show that after 28 days of use, the skin oil content of the products prepared in Examples 1 to 10 can be reduced by up to 22.7%, the oil control effect of the product is significantly improved, the a* value and the skin red-green value can be reduced by up to 10.23%, the redness caused by acne is significantly improved, the acne scar area is reduced by 39.6%, and the acne skin is significantly improved. After 3 days of use, the acne height of the products of Examples 1 to 10 is reduced by 23.04%, and the acne volume is significantly reduced by 15.38%, which significantly alleviates the acne problem. The above results show that the products prepared in Examples 1 to 10 of the present invention can significantly improve skin oil secretion and improve acne skin after use, have the effect of rapid oil control and acne removal in 3 days, and long-term use can improve skin redness caused by acne.

[0042] Test Example 6: The products obtained in Examples 1 to 10 and Comparative Example 11 were subjected to a skin occlusive patch test. The skin occlusive patch test method comprises the following steps: selecting a skin occlusive patch with an area not exceeding 50 mm 2 , a qualified spot test device with a depth of about 1mm. Add the test substance into the spot tester, with an amount of about 0.020-0.025g (solid or semi-solid) or 0.020-0.025mL (liquid). Apply the spot tester with the test substance and negative control to the curved side of the subject's forearm, and remove the spot tester after 24 hours. The skin reaction was observed according to the standard at 30 minutes, 2 hours and 48 hours after the test object was removed, and the observation results were recorded. The test subjects were people aged 18 to 25, and the number of test subjects was 33; scoring standard: Level 0: negative reaction; Level 1: suspicious reaction, only weak erythema; Level 2: weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present; Level 3: strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, and herpes: the reaction may exceed the test area; Level 4: extremely strong positive reaction (fusion herpes reaction); obvious erythema, severe infiltration, edema, and fusion herpes; the reaction exceeds the test area; the test results are shown in Table 6; Table 6 Skin patch test results Test Project Test Results Example 1 Skin occlusion patch test No adverse reactions Example 2 Skin occlusion patch test No adverse reactions Example 3 Skin occlusion patch test No adverse reactions Example 4 Skin occlusion patch test No adverse reactions Example 5 Skin occlusion patch test No adverse reactions Example 6 Skin occlusion patch test No adverse reactions Example 7 Skin occlusion patch test No adverse reactions Example 8 Skin occlusion patch test No adverse reactions Example 9 Skin occlusion patch test No adverse reactions Example 10 Skin occlusion patch test No adverse reactions Comparative Example 4 Skin occlusion patch test 2 cases of grade 1 adverse reactions Comparative Example 5 Skin occlusion patch test 1 case of grade 1 adverse reaction As shown in Table 6, the products prepared in Examples 1 to 10 did not produce any adverse reactions after the skin patch test, while Comparative Examples 4 and 5 both showed Grade 1 adverse reactions. The above results indicate that the products prepared in the present invention will not cause adverse reactions to the skin of adolescents aged 18 to 25 years old, and have the effect of mildly controlling oil and removing acne on adolescent skin.

[0043] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent transformation made to the above embodiment based on the technical essence of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A synergistic oil-controlling and acne-removing composition containing a scutellaria root extract, characterized in that: Included by mass: 0.05-1 part of Scutellaria baicalensis root extract, 0.3-2 parts of capryloyl glycine, Antioxidant 0.04-1.5 parts.

2. The synergistic oil-controlling and acne-removing composition containing the scutellaria baicalensis root extract according to claim 1, characterized in that: The antioxidant is one or both of sodium sulfite and sodium pyrosulfite.

3. The synergistic oil-controlling and acne-removing composition containing the scutellaria root extract according to claim 1, characterized in that: The baicalin content in the Scutellaria baicalensis root extract is ≥80%.

4. A method for preparing the synergistic oil-controlling and anti-acne composition containing the scutellaria root extract according to any one of claims 1 to 3, characterized in that: Capryloyl glycine is added to water, heated until dissolved and the pH is adjusted. After cooling, scutellaria root extract and antioxidants are added, mixed evenly and the pH is adjusted to prepare a synergistic oil-controlling and anti-acne composition containing scutellaria root extract.

5. The preparation method according to claim 4, characterized in that: The heating temperature is 75-85°C, and the cooling temperature is 35-40°C.

6. The preparation method according to claim 4, characterized in that: The pH is adjusted by using a pH regulator, which is one or more of arginine, aminomethyl propanol, sodium hydroxide, triethanolamine, and citric acid.

7. Use of a synergistic oil-controlling and acne-removing composition containing a scutellaria root extract in cosmetics, characterized in that: The cosmetic raw materials are made into cosmetics, wherein the cosmetic raw materials include the synergistic oil-controlling and anti-acne composition containing the scutellaria root extract according to any one of claims 1 to 3.

8. The use according to claim 7, characterized in that: The cosmetic raw materials also include one or two of solvents, moisturizers, preservatives, emollients, emulsifiers, and surfactants. The added amount of the synergistic oil-controlling and anti-acne composition containing the scutellaria root extract is 0.4-2.5%.

9. The use according to claim 7, characterized in that: The cosmetics are rinse-off products and leave-on products.

10. The use according to claim 7 or 9, characterized in that: The pH of the cosmetic is 5.0-7.0.

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