Active centrifugal force microfluidic integrated diagnosis platform

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to an active centrifugal force micro-fluidic integrated diagnosis platform, which comprises a diagnosis platform body, the bottom of which is fixedly provided with a support plate; the top shell is fixedly mounted at the top of the diagnosis platform body; the two sliding seats are mounted at the top of the top shell in a sliding manner; the front-back moving mechanism is arranged on the top shell and used for moving the sliding seat front and back; the two rotating grooves are formed in one sides of the two sliding seats; the rotating shaft is rotationally mounted in the two rotating grooves; the mounting frame is fixedly mounted on the outer side of the rotating shaft; the operation screen is fixedly mounted on the mounting frame; the first motor is fixedly mounted on one side of the sliding seat, and an output shaft of the first motor is fixedly connected with one end of the rotating shaft; according to the operating screen, the angle and the position of the operating screen can be conveniently adjusted, the operating screen can be used by different people, meanwhile, after the operating screen is used, disinfection can be conducted in time, and cross infection is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to an active centrifugal force microfluidic integrated diagnosis platform. Background Art

[0002] Microfluidics refers to the science and technology involved in systems that use microchannels (with dimensions of tens to hundreds of micrometers) to process or manipulate tiny fluids (volumes of nanoliters to attoliters). It is an emerging interdisciplinary subject involving chemistry, fluid physics, microelectronics, new materials, biology, and biomedical engineering. The active centrifugal force microfluidic integrated diagnostic platform is a device that combines microfluidics, wireless power supply, and wireless communication technologies to achieve automation and integration of biochemical detection processes. The platform uses the centrifugal force generated by the rotation of the motor as the driving force of the liquid, integrates the biochemical detection and analysis process on a disc the size of a CD, and achieves precise control and analysis of liquid flow through wireless power supply and communication technology. Based on active control and dual-state control technology, new processes such as electric-controlled valves, magnetic-controlled valves, precise temperature control, ultrasonic control, magnetic bead enrichment and purification, digital droplets, paraffin valve dispensing, wax-sealed reagent chambers and freeze-dried balls on the turntable are realized. Various optical detection technologies such as colorimetry, absorbance, fluorescence, chemiluminescence, SERS Raman spectroscopy, micro-nano meta-optics, etc. are integrated to achieve fully enclosed sample-in and -out one-piece detection for the entire process of biochemistry, immunology, molecular, and drug sensitivity.

[0003] The core technologies of the active centrifugal microfluidic integrated diagnostic platform include: Centrifugal microfluidic technology: using the centrifugal force generated by the rotation of the motor to drive the movement of the liquid in the chip to achieve sample processing and analysis. Wireless power supply technology: providing power to the platform wirelessly, simplifying the structure and operation of the equipment. Wireless communication technology: realizing real-time communication between the platform and external devices, facilitating remote control and data transmission. The main application areas of the platform include: Biomedical testing: used for nucleic acid extraction, polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA) and other biochemical tests. Public safety testing: used for rapid detection of viruses and water quality to improve detection efficiency and accuracy.

[0004] After searching, the patent document with publication (announcement) number: CN212646716U discloses a molecular diagnostic microfluidic detection device, including a device body and a square cover, a magnetic catheter is embedded in the top back side of the device body, a sampling tray is movably provided on the inner top of the square cover, a plurality of sampling slots are provided on the inner side of the sampling tray, a closing piece is fixed at the opening of the sampling slot, a liquid outlet pipe corresponding to the position of the plurality of sampling slots is fixed at the bottom of the sampling tray, and the liquid outlet pipe is conductively connected to the sampling slot, and a magnetic plug is provided on the inner side of the liquid outlet pipe.

[0005] The patent document with the publication (announcement) number: CN215694082U discloses a microfluidic chip and a molecular diagnostic device. The microfluidic chip includes a chip body and a drainage capillary provided on the chip body. A fixed hole is provided on the chip body, and the chip body can rotate around the fixed hole. The chip body is provided with an injection cavity and a mixing cavity connected to the injection cavity. The drainage capillary is connected to the mixing cavity, and the drainage capillary has a siphon section. The minimum distance from the siphon section to the fixed hole is less than the minimum distance from the mixing cavity to the fixed hole. Through such a structural layout, the chip body can form a siphon effect under the action of rotating centrifugation, which can improve the drainage efficiency of the liquid to be discharged in the mixing cavity of the microfluidic chip and reduce the consumption of reagents.

[0006] In the prior art, it is not convenient to adjust the operation screen of the active centrifugal force microfluidic integrated diagnostic platform when it is in use, and it cannot adapt to the usage needs of different groups of people. Therefore, we propose an active centrifugal force microfluidic integrated diagnostic platform to solve the above problems. Summary of the invention

[0007] The purpose of the present invention is to solve the shortcomings of the active centrifugal force microfluidic integrated diagnostic platform in the prior art, that is, it is inconvenient to adjust the operation screen when using it and it cannot adapt to the usage needs of different groups of people, and to propose an active centrifugal force microfluidic integrated diagnostic platform.

[0008] The active centrifugal force microfluidic integrated diagnostic platform provided in this application adopts the following technical solutions:

[0009] Active centrifugal force microfluidic integrated diagnostic platform, including:

[0010] The diagnostic platform body has a support plate fixedly installed at the bottom;

[0011] A top shell, fixedly mounted on the top of the diagnostic platform body;

[0012] Two sliding seats, slidably mounted on the top of the top shell;

[0013] A forward and backward moving mechanism is provided on the top shell and is used to move the sliding seat forward and backward;

[0014] Two rotating grooves are provided on one side of the two sliding seats;

[0015] A rotating shaft, rotatably mounted in the two rotating grooves;

[0016] A mounting frame, fixedly mounted on the outer side of the rotating shaft;

[0017] The operation screen is fixedly installed on the mounting frame;

[0018] A first motor is fixedly mounted on one side of the sliding seat, and an output shaft of the first motor is fixedly connected to one end of the rotating shaft;

[0019] The disinfection mechanism is arranged on the mounting frame and is used for disinfecting the operation screen.

[0020] Preferably, a sliding detection upper cover is provided in the top shell, a centrifugal seat is provided on the diagnostic platform body, a centrifugal microfluidic chip is provided on the centrifugal seat, and an upper cover switch and a power switch are provided on the diagnostic platform body.

[0021] Preferably, the front-rear moving mechanism includes two moving blocks, the top of the top shell is provided with two moving grooves, the two moving blocks are respectively slidably installed in the two moving grooves, and the two moving blocks are respectively fixedly connected to the two sliding seats.

[0022] Preferably, a first screw is rotatably installed in the movable groove, the first screw is threadedly connected to the movable block, a second motor is fixedly installed on the outer side of the top shell, and the output shaft of the second motor is fixedly connected to one end of the first screw.

[0023] Preferably, the disinfection mechanism comprises two sliders, one side of the two sliders is fixedly mounted with a same hollow plate, the hollow plate is located on one side of the mounting frame, and a plurality of spray holes are provided on a side of the hollow plate close to the mounting frame.

[0024] Preferably, two slide grooves are provided on one side of the mounting frame, and two sliding blocks are slidably installed in the two slide grooves respectively.

[0025] Preferably, a second screw is rotatably installed in the slide groove, the second screw is threadedly connected to the slider, a third motor is fixedly installed on the mounting frame, and the output shaft of the third motor is fixedly connected to one end of the second screw.

[0026] Preferably, a liquid storage tank is fixedly installed on one side of the hollow plate, a liquid filling port is provided on the liquid storage tank, a delivery pump is fixedly installed on one side of the liquid storage tank, the liquid outlet of the delivery pump is fixedly connected to a connecting pipe, and one end of the connecting pipe is fixedly connected to the hollow plate.

[0027] In summary, the present application includes at least one of the following beneficial technical effects:

[0028] The first motor drives the rotating shaft to rotate, the rotating shaft drives the mounting frame to rotate, the mounting frame drives the operating screen to rotate, and then the inclination angle of the operating screen is adjusted, the second motor drives the first screw to rotate, so that the moving block threadedly connected to the first screw slides forward or backward, and then drives the sliding seat to move, the sliding seat drives the rotating shaft to move, and the rotating shaft drives the mounting frame to move, so as to adjust the front and rear position of the operating screen;

[0029] After the operating screen is used, the second screw is driven to rotate by the third motor, so that the slider threadably connected to the second screw moves upward, and the slider drives the hollow plate to move upward. At the same time, the disinfectant in the liquid storage tank is extracted by the delivery pump, and delivered to the hollow plate through the connecting pipe, and finally sprayed to the operating screen from the spray hole to disinfect the operating screen and avoid cross infection.

[0030] The present invention facilitates adjustment of the angle and position of the operating screen to meet the needs of different groups of people. At the same time, the operating screen can be disinfected in time after use to avoid cross infection. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is a schematic diagram of the structure of the active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention;

[0032] Figure 2 A schematic diagram of the three-dimensional structure of the active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention from a first viewing angle;

[0033] Figure 3 A schematic diagram of the three-dimensional structure of the active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention from a second viewing angle;

[0034] Figure 4 A schematic diagram of the three-dimensional structure of the active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention from a third viewing angle;

[0035] Figure 5 The active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention Figure 3 Schematic diagram of the enlarged structure of part A of the species;

[0036] Figure 6 The active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention Figure 2 A schematic diagram of the enlarged structure of part B;

[0037] Figure 7 The active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention Figure 2 A schematic diagram of the enlarged structure of the middle C part;

[0038] Figure 8 The active centrifugal force microfluidic integrated diagnostic platform proposed by the present invention Figure 1 Schematic diagram of the enlarged structure of part D.

[0039] Figure numerals: 1. diagnostic platform body; 2. top shell; 3. sliding detection cover; 4. centrifugal seat; 5. centrifugal microfluidic chip; 6. cover switch; 7. power switch; 8. support plate; 9. moving groove; 10. moving block; 11. sliding seat; 12. rotating groove; 13. rotating shaft; 14. mounting frame; 15. operation screen; 16. first motor; 17. second motor; 18. first screw; 19. slide groove; 20. slider; 21. hollow plate; 22. liquid storage tank; 23. liquid filling port; 24. delivery pump; 25. connecting pipe; 26. second screw; 27. third motor. DETAILED DESCRIPTION

[0040] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0041] Embodiment 1

[0042] Reference Figure 1-Figure 8 , active centrifugal force microfluidic integrated diagnostic platform, including:

[0043] The diagnostic platform body 1 has a support plate 8 fixedly mounted at the bottom;

[0044] A top shell 2, fixedly mounted on the top of the diagnostic platform body 1;

[0045] Two sliding seats 11 are slidably mounted on the top of the top shell 2;

[0046] The forward and backward moving mechanism is provided on the top shell 2 and is used to move the sliding seat 11 forward and backward;

[0047] Two rotating grooves 12 are provided on one side of the two sliding seats 11;

[0048] A rotating shaft 13 is rotatably mounted in the two rotating grooves 12;

[0049] A mounting frame 14 is fixedly mounted on the outer side of the rotating shaft 13;

[0050] The operation screen 15 is fixedly mounted on the mounting frame 14;

[0051] A first motor 16 is fixedly mounted on one side of the sliding seat 11, and an output shaft of the first motor 16 is fixedly connected to one end of the rotating shaft 13;

[0052] The disinfection mechanism is arranged on the mounting frame 14 and is used to disinfect the operation screen 15 .

[0053] In this embodiment, a sliding detection cover 3 is provided in the top shell 2, a centrifugal seat 4 is provided on the diagnostic platform body 1, a centrifugal microfluidic chip 5 is provided on the centrifugal seat 4, and a cover switch 6 and a power switch 7 are provided on the diagnostic platform body 1.

[0054] In this embodiment, the front-rear moving mechanism includes two moving blocks 10 , and two moving grooves 9 are opened on the top of the top shell 2 . The two moving blocks 10 are respectively slidably installed in the two moving grooves 9 , and the two moving blocks 10 are respectively fixedly connected to two sliding seats 11 .

[0055] In this embodiment, a first screw 18 is rotatably installed in the movable groove 9 , and the first screw 18 is threadedly connected to the movable block 10 . A second motor 17 is fixedly installed on the outer side of the top shell 2 , and the output shaft of the second motor 17 is fixedly connected to one end of the first screw 18 .

[0056] In this embodiment, the disinfection mechanism includes two sliders 20 , and a same hollow plate 21 is fixedly mounted on one side of the two sliders 20 . The hollow plate 21 is located on one side of the mounting frame 14 , and a plurality of spray holes are provided on one side of the hollow plate 21 close to the mounting frame 14 .

[0057] In this embodiment, two slide grooves 19 are formed on one side of the mounting frame 14 , and two sliders 20 are slidably mounted in the two slide grooves 19 , respectively.

[0058] In this embodiment, a second screw rod 26 is rotatably installed in the slide groove 19 , and the second screw rod 26 is threadedly connected to the slider 20 . A third motor 27 is fixedly installed on the mounting frame 14 , and the output shaft of the third motor 27 is fixedly connected to one end of the second screw rod 26 .

[0059] In this embodiment, a liquid storage tank 22 is fixedly installed on one side of the hollow plate 21, and a liquid filling port 23 is provided on the liquid storage tank 22. A delivery pump 24 is fixedly installed on one side of the liquid storage tank 22, and the liquid outlet of the delivery pump 24 is fixedly connected to a connecting pipe 25, and one end of the connecting pipe 25 is fixedly connected to the hollow plate 21.

[0060] The implementation principle of this embodiment is as follows: when in use, the first motor 16 drives the rotating shaft 13 to rotate, the rotating shaft 13 drives the mounting frame 14 to rotate, and the mounting frame 14 drives the operating screen 15 to rotate, thereby adjusting the inclination angle of the operating screen 15, and the second motor 17 drives the first screw 18 to rotate, so that the moving block 10 threadedly connected to the first screw 18 slides forward or backward, thereby driving the sliding seat 11 to move, the sliding seat 11 drives the rotating shaft 13 to move, and the rotating shaft 13 drives the mounting frame 14 to move, thereby adjusting the front and rear position of the operating screen 15; after the operating screen 15 is used, the third motor 27 drives the second screw 26 to rotate, so that the slider 20 threadedly connected to the second screw 26 moves upward, and the slider 20 drives the hollow plate 21 to move upward, and at the same time, the disinfectant in the liquid storage tank 22 is extracted by the delivery pump 24, and delivered to the hollow plate 21 through the connecting pipe 25, and finally sprayed from the spray hole to the operating screen 15, so as to disinfect the operating screen 15 and avoid cross infection.

[0061] Embodiment 2

[0062] Active centrifugal force microfluidic integrated diagnostic platform, including:

[0063] The diagnostic platform body 1 has a support plate 8 fixedly mounted at the bottom;

[0064] A top shell 2, fixedly mounted on the top of the diagnostic platform body 1;

[0065] Two sliding seats 11 are slidably mounted on the top of the top shell 2;

[0066] The forward and backward moving mechanism is provided on the top shell 2 and is used to move the sliding seat 11 forward and backward;

[0067] Two rotating grooves 12 are provided on one side of the two sliding seats 11;

[0068] A rotating shaft 13 is rotatably mounted in the two rotating grooves 12;

[0069] A mounting frame 14 is fixedly mounted on the outer side of the rotating shaft 13;

[0070] The operation screen 15 is fixedly mounted on the mounting frame 14;

[0071] A first motor 16 is fixedly mounted on one side of the sliding seat 11, and an output shaft of the first motor 16 is fixedly connected to one end of the rotating shaft 13;

[0072] The disinfection mechanism is arranged on the mounting frame 14 and is used to disinfect the operation screen 15 .

[0073] A lifting mechanism is provided at the bottom of the diagnostic platform body 1 and is used to adjust the height of the diagnostic platform body 1;

[0074] In this embodiment, a sliding detection cover 3 is provided in the top shell 2, a centrifugal seat 4 is provided on the diagnostic platform body 1, a centrifugal microfluidic chip 5 is provided on the centrifugal seat 4, and a cover switch 6 and a power switch 7 are provided on the diagnostic platform body 1.

[0075] In this embodiment, the lifting mechanism includes multiple cylinders, the output shafts of the multiple cylinders are fixedly connected to the bottom of the diagnostic platform body 1, and the bottom of the multiple cylinders is fixedly installed with the same base plate, and the height of the diagnostic platform body 1 is adjusted by the multiple cylinders.

[0076] In this embodiment, the front-rear moving mechanism includes two moving blocks 10 , and two moving grooves 9 are opened on the top of the top shell 2 . The two moving blocks 10 are respectively slidably installed in the two moving grooves 9 , and the two moving blocks 10 are respectively fixedly connected to two sliding seats 11 .

[0077] In this embodiment, a first screw 18 is rotatably installed in the movable groove 9 , and the first screw 18 is threadedly connected to the movable block 10 . A second motor 17 is fixedly installed on the outer side of the top shell 2 , and the output shaft of the second motor 17 is fixedly connected to one end of the first screw 18 .

[0078] In this embodiment, the disinfection mechanism includes two sliders 20 , and a same hollow plate 21 is fixedly mounted on one side of the two sliders 20 . The hollow plate 21 is located on one side of the mounting frame 14 , and a plurality of spray holes are provided on one side of the hollow plate 21 close to the mounting frame 14 .

[0079] In this embodiment, two slide grooves 19 are formed on one side of the mounting frame 14 , and two sliders 20 are slidably mounted in the two slide grooves 19 , respectively.

[0080] In this embodiment, a second screw rod 26 is rotatably installed in the slide groove 19 , and the second screw rod 26 is threadedly connected to the slider 20 . A third motor 27 is fixedly installed on the mounting frame 14 , and the output shaft of the third motor 27 is fixedly connected to one end of the second screw rod 26 .

[0081] In this embodiment, a liquid storage tank 22 is fixedly installed on one side of the hollow plate 21, and a liquid filling port 23 is provided on the liquid storage tank 22. A delivery pump 24 is fixedly installed on one side of the liquid storage tank 22, and the liquid outlet of the delivery pump 24 is fixedly connected to a connecting pipe 25, and one end of the connecting pipe 25 is fixedly connected to the hollow plate 21.

[0082] The implementation principle of this embodiment is as follows: when in use, the first motor 16 drives the rotating shaft 13 to rotate, the rotating shaft 13 drives the mounting frame 14 to rotate, and the mounting frame 14 drives the operating screen 15 to rotate, thereby adjusting the inclination angle of the operating screen 15, and the second motor 17 drives the first screw 18 to rotate, so that the moving block 10 threadedly connected to the first screw 18 slides forward or backward, thereby driving the sliding seat 11 to move, the sliding seat 11 drives the rotating shaft 13 to move, and the rotating shaft 13 drives the mounting frame 14 to move, thereby adjusting the front and rear position of the operating screen 15; after the operating screen 15 is used, the third motor 27 drives the second screw 26 to rotate, so that the slider 20 threadedly connected to the second screw 26 moves upward, and the slider 20 drives the hollow plate 21 to move upward, and at the same time, the disinfectant in the liquid storage tank 22 is extracted by the delivery pump 24, and delivered to the hollow plate 21 through the connecting pipe 25, and finally sprayed from the spray hole to the operating screen 15, so as to disinfect the operating screen 15 and avoid cross infection.

[0083] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. Active centrifugal force microfluidic integrated diagnostic platform, characterized by: include: Diagnostic platform ontology (1); A top shell (2) is fixedly mounted on the top of the diagnostic platform body (1); Two sliding seats (11) are slidably mounted on the top of the top shell (2); A rotating shaft (13) is rotatably mounted on the two sliding seats (11); A mounting frame (14) fixedly mounted on the outer side of the rotating shaft (13); An operating screen (15) is fixedly mounted on the mounting frame (14); A forward and backward moving mechanism is arranged on the top shell (2) and is used to move the sliding seat (11) forward and backward, thereby adjusting the position of the operating screen (15); The disinfection mechanism is arranged on the mounting frame (14) and is used to disinfect the operation screen (15) to avoid cross infection after different groups of people use the screen.

2. The active centrifugal force microfluidic integrated diagnostic platform according to claim 1, characterized in that: A sliding detection upper cover (3) is provided in the top shell (2), a centrifugal seat (4) is provided on the diagnostic platform body (1), a centrifugal microfluidic chip (5) is provided on the centrifugal seat (4), an upper cover switch (6) and a power switch (7) are provided on the diagnostic platform body (1), and a rotating groove (12) is provided on one side of the two sliding seats (11), and a rotating shaft (13) is rotatably installed in the two rotating grooves (12).

3. The active centrifugal force microfluidic integrated diagnostic platform according to claim 2, characterized in that: The front-rear moving mechanism comprises two moving blocks (10), the top of the top shell (2) is provided with two moving grooves (9), the two moving blocks (10) are respectively slidably installed in the two moving grooves (9), and the two moving blocks (10) are respectively fixedly connected to two sliding seats (11).

4. The active centrifugal force microfluidic integrated diagnostic platform according to claim 3, characterized in that: A first screw rod (18) is rotatably mounted in the movable groove (9), the first screw rod (18) is threadedly connected to the movable block (10), a second motor (17) is fixedly mounted on the outer side of the top shell (2), and an output shaft of the second motor (17) is fixedly connected to one end of the first screw rod (18).

5. The active centrifugal force microfluidic integrated diagnostic platform according to claim 4, characterized in that: The disinfection mechanism comprises two sliders (20), one side of the two sliders (20) being fixedly mounted with a same hollow plate (21), the hollow plate (21) being located on one side of the mounting frame (14), and a plurality of spray holes being provided on a side of the hollow plate (21) close to the mounting frame (14).

6. The active centrifugal force microfluidic integrated diagnostic platform according to claim 5, characterized in that: Two slide grooves (19) are provided on one side of the mounting frame (14), and two sliding blocks (20) are slidably mounted in the two slide grooves (19) respectively.

7. The active centrifugal force microfluidic integrated diagnostic platform according to claim 6, characterized in that: A second screw rod (26) is rotatably mounted in the slide groove (19), the second screw rod (26) is threadedly connected to the slider (20), a third motor (27) is fixedly mounted on the mounting frame (14), and an output shaft of the third motor (27) is fixedly connected to one end of the second screw rod (26).

8. The active centrifugal force microfluidic integrated diagnostic platform according to claim 7, characterized in that: A liquid storage tank (22) is fixedly mounted on one side of the hollow plate (21), and a liquid filling port (23) is provided on the liquid storage tank (22). A delivery pump (24) is fixedly mounted on one side of the liquid storage tank (22), and a liquid outlet of the delivery pump (24) is fixedly connected to a connecting pipe (25), and one end of the connecting pipe (25) is fixedly connected to the hollow plate (21).

9. The active centrifugal force microfluidic integrated diagnostic platform according to claim 8, characterized in that: A first motor (16) is fixedly mounted on one side of the sliding seat (11), and an output shaft of the first motor (16) is fixedly connected to one end of the rotating shaft (13).

10. The active centrifugal force microfluidic integrated diagnostic platform according to claim 9, characterized in that: A support plate (8) is fixedly mounted on the bottom of the diagnostic platform body (1).

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