Left atrial appendage occluder and left atrial appendage occlusion device

Abstract

The present invention provides a left atrial appendage occluder and a left atrial appendage occluding device. The left atrial appendage occluder comprises: an occluding disk and a fixed disk, the fixed disk is connected to the occluding disk; a flow blocking membrane, the flow blocking membrane is movably arranged on the outer surface of the occluding disk; a first connecting member, the first connecting member is arranged on the fixed disk and is located at the center of the fixed disk; an elastic member, the elastic member is arranged on the occluding disk, and the elastic member is coaxially arranged with the first connecting member; a control line, one end of the control line is connected to the edge of the flow blocking membrane, and the other end passes through the first connecting member and is connected to the elastic member, so as to tension the flow blocking membrane under the elastic force of the elastic member. The present invention solves the problem of poor applicability of the left atrial appendage occluder in the prior art.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a left atrial appendage occluder and a left atrial appendage occluding device. Background Art

[0002] Atrial fibrillation is the most common arrhythmia in clinical practice, with an incidence rate of 1% to 2%, and is more likely to cause serious complications such as stroke. More than 90% of the thrombi in patients with non-valvular atrial fibrillation come from the left atrial appendage. Closing or blocking the left atrial appendage can greatly reduce the formation of thrombi and reduce the risk of stroke. Traditional treatment methods include oral anticoagulants, radiofrequency ablation, and left atrial appendage ligation surgery, but oral anticoagulants are prone to cause serious complications, and radiofrequency ablation and surgical ligation are traumatic and expensive. All of the above solutions have their shortcomings. At present, left atrial appendage occlusion is a new type of minimally invasive interventional method with less trauma, no need for long-term oral anticoagulation, and good results. It is becoming more and more popular among patients and medical staff.

[0003] The internal morphology of the left atrial appendage is complex, showing a variety of anatomical forms, with well-developed pectinate muscles on the inner wall and different shapes of the left atrial appendage mouth. The main left atrial appendage occluders on the market can be roughly divided into two categories, plug-type and disc-type, each with its own characteristics. Both are provided with flow-blocking membranes on their surfaces. The overall shape of the plug-type occluder is close to cylindrical, penetrating into the atrial appendage to stretch the left atrial appendage to achieve the purpose of occlusion. However, due to the complex and irregular shape of the left atrial appendage, its adaptability to the double-chamber left atrial appendage is poor. The disc-type occluder is mainly a split design with good device stability. It is divided into an occluding disc and a fixed disc. Therefore, the overall height of the device is relatively large and cannot adapt well to the shallow left atrial appendage. At the same time, the occluding disc of the disc-type occluder has the risk of affecting the normal function of the left superior pulmonary vein and mitral valve. There are also some common problems between the two types of LAA occluders. The mainstream LAA occluders on the market are currently fixed with barbs. This design can ensure good stability and prevent the LAA occluder from moving, but it also brings the risk of puncturing the atrial appendage and causing perforation and pericardial effusion. At the same time, the mainstream occluders on the market have poor adaptability to size, and one specification can only cover a specific, smaller range of atrial appendage sizes. In addition, the LAA occluder implanted in LAAs of different sizes will shrink to varying degrees, causing the flow-blocking membrane on the occlusion disk to wrinkle and be unable to cover the surface of the occlusion disk evenly, affecting the normal function of the flow-blocking membrane, resulting in poor applicability of the LAA occluder.

[0004] As can be seen from the above, the existing technology has the problem of poor applicability of left atrial appendage occluders. Summary of the invention

[0005] The main purpose of the present invention is to provide a left atrial appendage occluder and a left atrial appendage occluding device to solve the problem of poor applicability of left atrial appendage occluders in the prior art.

[0006] In order to achieve the above-mentioned purpose, according to one aspect of the present invention, a left atrial appendage occluder is provided, comprising: an occluding disk and a fixed disk, the fixed disk being connected to the occluding disk; a baffle membrane, the baffle membrane being movably arranged on the outer surface of the occluding disk; a first connecting member, the first connecting member being arranged on the fixed disk and located at the center of the fixed disk; an elastic member, the elastic member being arranged on the occluding disk, the elastic member being coaxially arranged with the first connecting member; and a control line, one end of the control line being connected to the edge of the baffle membrane, and the other end passing through the first connecting member and being connected to the elastic member, so as to tension the baffle membrane under the elastic force of the elastic member.

[0007] Furthermore, there are multiple control lines, and the multiple control lines are arranged at intervals along the circumference of the flow-blocking membrane.

[0008] Furthermore, the left atrial appendage occluder includes a first support rod and a second support rod, there are multiple first support rods and the multiple first support rods are arranged at intervals along the circumference of the occlusion disk, one end of the first support rod is connected to the first connecting piece, and the two ends of each second support rod are respectively connected to two adjacent first support rods, and at least a portion of the first support rod, the second support rod and the first connecting piece form a fixed disk.

[0009] Furthermore, the first support rod includes a first connecting section, a second connecting section and a third connecting section, the two ends of each second support rod are respectively connected to two adjacent first connecting sections, and multiple first connecting sections are respectively connected to the first connecting member, and the first connecting section, the second connecting section, the second support rod and the first connecting member form a fixed plate.

[0010] Furthermore, the left atrial appendage occluder also includes: a third support rod, there are multiple third support rods, and both ends of each third support rod are respectively connected to two adjacent third connecting segments; a second connecting piece, multiple third connecting segments are respectively connected to the second connecting piece, the first connecting piece is coaxially arranged with the second connecting piece, and the third connecting segment, the third support rod and the second connecting piece form an occluding disk.

[0011] Furthermore, the first connecting segment, the third connecting segment, the second support rod and the third support rod are all arc-shaped, and two adjacent first connecting segments and one second support rod form a petal-shaped structure; and / or two adjacent third connecting segments and one third support rod form a petal-shaped structure.

[0012] Furthermore, the first connecting segment and the third connecting segment are both arc-shaped as a whole; or the first connecting segment and the third connecting segment both have multiple arc-shaped bends.

[0013] Furthermore, the second connecting section has a bent ox-horn hook structure for connecting to the inner wall of the left atrial appendage, and the ox-horn hook structure has rounded edges.

[0014] Furthermore, there are multiple bull-horn hook structures, and the multiple bull-horn hook structures are arranged at intervals along the extension direction of the second connecting section.

[0015] Furthermore, the second connecting section is arranged parallel to or at an angle to the axis of the left atrial appendage occluder.

[0016] Furthermore, the left atrial appendage occluder also includes a third connecting piece, which is detachably connected to the second connecting piece and is used to be connected to a delivery cable of the left atrial appendage occluding device.

[0017] Furthermore, the first connecting member and the second connecting member are connecting rings, the third connecting member is a connecting nut, the third connecting member is threadedly connected to the second connecting member, and the third connecting member is fixedly connected to the elastic member.

[0018] Furthermore, the left atrial appendage occluder also includes a guide member, and there are multiple guide members, and the multiple guide members are arranged on the first support rod at intervals, and the control line passes through the multiple guide members.

[0019] Furthermore, a connecting piece is provided at the edge of the flow-blocking membrane, and there are a plurality of connecting pieces, which are arranged at intervals along the circumference of the flow-blocking membrane, and the plurality of control lines are respectively connected to the plurality of connecting pieces.

[0020] According to another aspect of the present invention, a left atrial appendage occlusion device is provided, comprising a delivery cable, a delivery sheath and the above-mentioned left atrial appendage occluder, wherein the left atrial appendage occluder is accommodated in the delivery sheath, and the delivery cable is detachably connected to the left atrial appendage occluder.

[0021] According to the technical solution of the present invention, the left atrial appendage occluder includes an occluding disk and a fixed disk, a flow-blocking membrane, a first connecting piece, an elastic piece and a control line. The fixed disk is connected to the occluding disk, the flow-blocking membrane is movably arranged on the outer surface of the occluding disk, the first connecting piece is arranged on the fixed disk and located at the center of the fixed disk, the elastic piece is arranged on the occluding disk, the elastic piece is coaxially arranged with the first connecting piece, one end of the control line is connected to the edge of the flow-blocking membrane, and the other end passes through the first connecting piece and is connected to the elastic piece to tension the flow-blocking membrane under the elastic force of the elastic piece. By arranging the elastic piece on the occluding disk, the flow-blocking membrane is movably arranged on the occluding disk, and the control line One end of the control line is connected to the flow-blocking membrane, and the other end passes through the first connecting piece arranged on the fixed disk and is connected to the elastic piece. When the occluding disk and the fixed disk are squeezed and deformed by the inner wall of the left atrial appendage, the elastic piece is used to shrink and pull the control line to tighten the flow-blocking membrane, so that the flow-blocking membrane moves along the occluding disk and always remains flat on the surface of the occluding disk, thereby increasing the adaptability of the left atrial appendage occluder to left atrial appendages of different sizes, avoiding the provision of left atrial appendage occluders of various specifications, reducing the difficulty of users in selecting instruments of appropriate specifications, improving the applicability of the left atrial appendage occluder, and solving the problem of poor applicability of the left atrial appendage occluder in the prior art. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The drawings constituting a part of the present application are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0023] Figure 1 A schematic structural diagram showing a first angle of a left atrial appendage occluder in a specific embodiment of the present invention;

[0024] Figure 2 A schematic structural diagram of a left atrial appendage occluder in a specific embodiment of the present invention from a second angle is shown;

[0025] Figure 3 A schematic structural diagram showing a third angle of a left atrial appendage occluder in a specific embodiment of the present invention;

[0026] Figure 4 Shows Figure 3 A partial enlarged view of the middle A;

[0027] Figure 5 A schematic diagram showing the structure of a left atrial appendage occluder for occluding a left atrial appendage in a specific embodiment of the present invention is shown;

[0028] Figure 6 A schematic diagram showing the structure of a left atrial appendage occluder in a specific embodiment of the present invention that is not adapted to the size of the left atrial appendage;

[0029] Figure 7 A schematic structural diagram showing a left atrial appendage occluder adapted to the left atrial appendage size in a specific embodiment of the present invention is shown;

[0030] Figure 8 A schematic structural diagram showing a first angle of a left atrial appendage occluder in another specific embodiment of the present invention;

[0031] Fig. 9 A schematic structural diagram showing a second angle of a left atrial appendage occluder in another specific embodiment of the present invention;

[0032] Fig.10 A schematic structural diagram showing a third angle of a left atrial appendage occluder in another specific embodiment of the present invention;

[0033] Fig.11 A schematic diagram showing the structure of a left atrial appendage occluder for occluding a left atrial appendage in another specific embodiment of the present invention is shown;

[0034] Fig.12 A schematic structural diagram showing a first angle of a left atrial appendage occluder in another specific embodiment of the present invention is shown;

[0035] Fig.13A schematic structural diagram showing a second angle of a left atrial appendage occluder in another specific embodiment of the present invention;

[0036] Fig.14 A schematic structural diagram of a left atrial appendage occluder in another specific embodiment of the present invention is shown at a third angle.

[0037] The above drawings include the following reference numerals:

[0038] 10. Sealing disk; 20. Fixed disk; 30. Flow-blocking membrane; 31. Connecting piece; 40. First connecting piece; 50. Elastic piece; 51. First connecting seat; 52. Second connecting seat; 60. Control line; 70. First support rod; 71. First connecting section; 72. Second connecting section; 73. Third connecting section; 80. Second support rod; 90. Third support rod; 100. Second connecting piece; 110. Third connecting piece; 120. Guide piece; 130. Horn hook structure; 140. Metal sleeve. DETAILED DESCRIPTION

[0039] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0040] It should be noted that, unless otherwise specified, all technical and scientific terms used in this application have the same meanings as commonly understood by ordinary technicians in the technical field to which this application belongs.

[0041] In the present invention, unless otherwise specified, the directional words used, such as "up, down, top, bottom", usually refer to the directions shown in the drawings, or to the components themselves in the vertical, perpendicular or gravity directions; similarly, for ease of understanding and description, "inside and outside" refer to the inside and outside relative to the outline of each component itself, but the above-mentioned directional words are not used to limit the present invention.

[0042] Obviously, the above-described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0043] In order to solve the problem of poor applicability of the left atrial appendage occluder in the prior art, the present invention provides a left atrial appendage occluder and a left atrial appendage occluding device. The left atrial appendage occluding device includes the left atrial appendage occluder.

[0044] like Figures 1 to 14As shown, the left atrial appendage occluder includes an occluding disk 10 and a fixed disk 20, a flow-blocking membrane 30, a first connecting member 40, an elastic member 50 and a control line 60. The fixed disk 20 is connected to the occluding disk 10. The flow-blocking membrane 30 is movably arranged on the outer surface of the occluding disk 10. The first connecting member 40 is arranged on the fixed disk 20 and is located at the center of the fixed disk 20. The elastic member 50 is arranged on the occluding disk 10, and the elastic member 50 is coaxially arranged with the first connecting member 40. One end of the control line 60 is connected to the edge of the flow-blocking membrane 30, and the other end passes through the first connecting member 40 and is connected to the elastic member 50, so as to tension the flow-blocking membrane 30 under the elastic force of the elastic member 50.

[0045] By arranging an elastic member 50 on the occluding disk 10, the baffle membrane 30 is movably arranged on the occluding disk 10, one end of the control line 60 is connected to the baffle membrane 30, and the other end passes through the first connecting member 40 arranged on the fixed disk 20 and is connected to the elastic member 50. When the occluding disk 10 and the fixed disk 20 are squeezed and deformed by the inner wall of the left atrial appendage, the elastic member 50 is used to shrink and pull the control line 60 to tighten the baffle membrane 30, so that the baffle membrane 30 moves along the occluding disk 10 and always remains flat on the surface of the occluding disk 10, thereby increasing the adaptability of the left atrial appendage occluder to left atrial appendages of different sizes, avoiding the setting of left atrial appendage occluders of various specifications, reducing the difficulty of users in selecting instruments of appropriate specifications, and improving the applicability of the left atrial appendage occluder.

[0046] In this embodiment, there are multiple control lines 60, and the multiple control lines 60 are arranged at intervals along the circumference of the baffle film 30. Further, the multiple control lines 60 are arranged at equal intervals along the circumference of the baffle film 30, so that the baffle film 30 is uniformly subjected to the elastic force of the elastic member 50 along the circumference, thereby making the baffle film 30 better kept flat on the surface of the blocking disk 10.

[0047] In this embodiment, the first connecting member 40 is a connecting ring.

[0048] Specifically, the elastic member 50 is located between the blocking disk 10 and the fixed disk 20, and a plurality of control lines 60 respectively pass through the first connecting member 40 and connect the bottom end of the elastic member 50. It can be understood that the first connecting member 40 is a force support point for the control line 60, and a plurality of control lines 60 are collected through the first connecting member 40 and connected to the elastic member 50. Optionally, the first connecting member 40 serves as a channel for the control line 60, and the diameter of the first connecting member 40 is not greater than 5 mm to reduce the use of space in the fixed disk 20.

[0049] In this embodiment, the elastic member 50 is a spring. Specifically, the spring is always in a stretched state, thereby providing elastic force for the control line 60 to ensure that the flow-blocking film 30 is always in a tensioned state. Of course, the elastic member 50 can also be made of a high-elastic polymer material, which can be selected according to actual needs.

[0050] like Figure 1 to Figure 2 , Figure 8 and Fig.10 as well as Fig.12 and Fig.14 As shown, the left atrial appendage occluder includes a first support rod 70 and a second support rod 80. There are multiple first support rods 70 and second support rods 80, and multiple first support rods 70 are arranged at intervals along the circumference of the occlusion disk 10. One end of the first support rod 70 is connected to the first connecting member 40, and the two ends of each second support rod 80 are respectively connected to two adjacent first support rods 70, and at least a portion of the first support rod 70, the second support rod 80 and the first connecting member 40 form a fixed disk 20.

[0051] Specifically, Figures 1 to 4 , Figures 8 to 10 as well as Figure 12 to Figure 14 As shown, the first support rod 70 includes a first connecting section 71, a second connecting section 72 and a third connecting section 73, and both ends of each second support rod 80 are respectively connected to two adjacent first connecting sections 71, and multiple first connecting sections 71 are respectively connected to the first connecting member 40, and the first connecting section 71, the second connecting section 72, the second support rod 80 and the first connecting member 40 form a fixed plate 20.

[0052] Specifically, multiple first support rods 70 are arranged at intervals along the circumference of the first connecting member 40, and the first connecting segment 71 is welded to the outer wall of the ring of the first connecting member 40. Furthermore, the planes where the first connecting segment 71 and the third connecting segment 73 are located are parallel or approximately parallel to each other, and the first connecting segment 71, the second connecting segment 72 and the third connecting segment 73 are connected in sequence. Each second support rod 80 connects two adjacent first connecting segments 71 so that the entire fixed disk 20 forms a complete disk surface.

[0053] like Figure 1 , Figure 3 to Figure 4 , Fig.10 and Fig.14 As shown, the left atrial appendage occluder further includes a third support rod 90 and a second connecting member 100. There are multiple third support rods 90, and the two ends of each third support rod 90 are respectively connected to two adjacent third connecting segments 73. Multiple third connecting segments 73 are respectively connected to the second connecting member 100, the first connecting member 40 and the second connecting member 100 are coaxially arranged up and down, and the third connecting segment 73, the third support rod 90 and the second connecting member 100 form an occluding disk 10.

[0054] In this embodiment, the second connecting member 100 is also a connecting ring.

[0055] Specifically, the two ends of each third support rod 90 are connected to two adjacent third connecting sections 73, and the second connecting member 100 is provided with a plurality of spaced connecting holes, and the plurality of third connecting sections 73 extend into the connecting holes and are welded with the connecting holes, thereby forming a closure plate 10. The disk surface of the closure plate 10 is parallel or substantially parallel to the disk surface of the fixed disk 20. The outer shape of the entire left atrial appendage occluder is a plug-like structure. In actual use, the closure plate 10 overlaps the mouth of the left atrial appendage, thereby completely blocking the left atrial appendage to prevent residual leakage. At the same time, the disk surfaces of the closure plate 10 and the fixed disk 20 are respectively formed by connecting the two ends of the plurality of first support rods 70 with the plurality of third support rods 90 and the plurality of second support rods 80. The entire left atrial appendage occluder is formed by the first support rod 70 to form the main skeleton. This arrangement is conducive to reducing the overall height of the device and improving the adaptability of the left atrial appendage occluder to left atrial appendages of different depths.

[0056] In this embodiment, if Figure 1 to Figure 2 , Figure 8 , Fig.10 , Fig.12 and Fig.14 As shown, the first connecting section 71 and the second support rod 80 and the third connecting section 73 and the third support rod 90 are connected by crimping with a metal sleeve 140. Optionally, the first connecting section 71 and the second support rod 80 and the third connecting section 73 and the third support rod 90 are connected by welding or bonding.

[0057] In this embodiment, the first connecting segment 71, the third connecting segment 73, the second support rod 80 and the third support rod 90 are all arc-shaped, two adjacent first connecting segments 71 and one second support rod 80 form a first petal-shaped structure, and two adjacent third connecting segments 73 and one third support rod 90 form a second petal-shaped structure. Further, the two petal-shaped structures are parallel or substantially parallel to each other.

[0058] Specifically, one end of the second support rod 80 is connected to the end of one of the two adjacent first connecting segments 71, and the other end is connected to the middle position of the other first connecting segment 71, thereby forming a petal shape. Similarly, one end of the third support rod 90 is connected to the end of one of the two adjacent third connecting segments 73, and the other end is connected to the middle position of the other third connecting segment 73, thereby forming a petal shape. A plurality of petal-shaped structures are formed on the occluding disk 10 and the fixed disk 20, that is, the disk surface of the fixed disk 20 and the occluding disk 10 can be regarded as a petal-shaped structure, and the first connecting segment 71, the third connecting segment 73, the second support rod 80 and the third support rod 90 have a certain structural strength. After the petal-shaped structure is formed, each petal has a certain structural strength. When subjected to radial compression, it will only rotate and contract to a certain extent around the axis of the left atrial appendage occluder, and no convex deformation of the disk surface will occur.

[0059] In the present embodiment, the first connecting segment 71 and the third connecting segment 73 are both arc-shaped as a whole. It is understandable that when the left atrial appendage occluder is subjected to radial compression, the disk surfaces of the occluding disk 10 and the fixing disk 20 shrink to a certain extent, and the overall petal-shaped structure rotates inward in the circumferential direction, thereby reducing the disk surface area of ​​the occluding disk 10 and the fixing disk 20. Specifically, the fixing disk 20 is first radially compressed to adapt to the shape of the left atrial appendage, so that the first connecting segment 71 and the second support rod 80 rotate inward and shrink. Due to the overall design of the first support rod 70, the shape of the left atrial appendage mouth is transmitted to the occluding disk 10 through the second connecting segment 72, that is, the third connecting segment 73 and the third support rod 90 rotate inward and shrink accordingly, so that it changes with the shape of the left atrial appendage mouth, while improving the adaptability of the complex shape of the left atrial appendage, while reducing the risk of blocking peripheral organs, such as the left upper pulmonary vein and the mitral valve. Figures 5 to 7 As shown. Furthermore, due to the reduction in the disk area of ​​the blocking disk 10, the baffle film 30 cannot evenly cover the disk surface of the blocking disk 10. At this time, the elastic member 50 contracts, driving the control line 60 to move, thereby driving the baffle film 30 to move on the disk surface of the blocking disk 10 and tensioning the baffle film 30, and finally adapting to the shape of the blocking disk 10, and allowing the surface of the baffle film 30 to continue to remain flat. Similarly, when the disk area of ​​the blocking disk 10 increases, that is, the third connecting section 73 and the third support rod 90 rotate and expand outward, the baffle film 30 moves relative to the disk surface of the blocking disk 10, thereby driving the control line 60 to move, so that the elastic member 50 is stretched, and the baffle film 30 continues to be tensioned and maintains a flat surface under the elastic force of the elastic member 50.

[0060] like Figures 1 to 3 , Figures 8 to 10 as well as Figure 12 to Figure 14 As shown, the left atrial appendage occluder further includes a guide member 120 , and there are multiple guide members 120 . The multiple guide members 120 are arranged on the first support rod 70 at intervals, and the control line 60 passes through the multiple guide members 120 .

[0061] Specifically, the guide member 120 is a guide ring, and the guide ring is welded to the first support rod 70. A plurality of guide members 120 are arranged on the first support rod 70 at intervals, and the control line 60 passes through a plurality of guide members 120, so that the control line 60 and the first support rod 70 are kept in close contact, and the control line 60 is prevented from being routed in a disordered manner, causing the elastic member 50 to be unable to drive the control line 60 to move. Optionally, the plurality of guide members 120 are located on the same side of the first support rod 70 to facilitate the movement of the control line 60.

[0062] like Figures 1 to 4 , Figures 8 to 10 as well as Figure 12 to Figure 14As shown, the second connecting segment 72 has a bent ox-horn hook structure 130, which is used to connect with the inner wall of the left atrial appendage, and the ox-horn hook structure 130 has rounded edges. The pectinate muscles inside the left atrial appendage are shaped like quilts folded layer by layer, and are densely distributed inside the left atrial appendage. In order to increase the implantation stability of the left atrial appendage occluder, the conventional practice is to add barbs to the left atrial appendage occluder, and rely on them to penetrate the atrial appendage tissue to achieve the purpose of fixation. However, since the barbs are invasive operations, the risk is relatively large, and it is easy to cause risks such as left heart perforation and pericardial effusion. The ox-horn hook structure 130 in this embodiment is bent and shaped by the second connecting segment 72, and is formed as a fixing hook on the side of the left atrial appendage occluder. When the left atrial appendage occluder is used, the ox-horn hook structure 130 penetrates the pectinate muscles of the inner wall of the left atrial appendage, and the edge of the ox-horn hook structure 130 is approximately arc-shaped, thereby avoiding the tip penetrating the pectinate muscles to cause serious damage to the left atrial appendage, or even piercing the left atrial appendage to form pericardial effusion, thereby reducing the possibility of surgical complications.

[0063] In this embodiment, there are multiple bull-horn hook structures 130 , and the multiple bull-horn hook structures 130 are arranged at intervals along the extension direction of the second connecting section 72 .

[0064] Specifically, the multiple ox-horn hook structures 130 are formed by continuous and repeated bending to form a wave-like structure.

[0065] Furthermore, since there are multiple first support rods 70 and the multiple first support rods 70 are arranged at intervals along the circumference of the occlusion disk 10, the left atrial appendage occluder in this embodiment has multiple groups of bull horn hook structures along the circumference, thereby increasing the probability and number of the bull horn hook structures 130 hooking into the pectinate muscles, thereby increasing the stability of the device.

[0066] In this embodiment, the second connecting segment 72 is parallel or approximately parallel to the axis of the left atrial appendage occluder. It should be noted that the above-mentioned approximately parallel means that the angle between the second connecting segment 72 and the axis of the left atrial appendage occluder is very small and approximately parallel, but not completely overlapped and almost invisible to the naked eye.

[0067] Specifically, the second connecting segment 72 is perpendicular to the plane where the first connecting segment 71 and the third connecting segment 73 are located. In the stored state, the second connecting segment 72 contracts along the radial direction of the left atrial appendage occluder. In the released state, the second connecting segment 72 expands along the radial direction of the left atrial appendage occluder. The entire left atrial appendage occluder expands, and the horn hook structure 130 penetrates into the pectinate muscle along the radial direction of the left atrial appendage occluder, thereby increasing the effectiveness of fixation and achieving fixation of the left atrial appendage occluder.

[0068] In another embodiment of the present application, the second connecting segment 72 is arranged at an angle to the axial direction of the left atrial appendage occluder.

[0069] Specifically, Figures 8 to 11As shown, the second connecting segment 72 forms an acute angle with the axial direction of the left atrial appendage occluder, that is, the second connecting segment 72 is inclined. Similarly, the second connecting segment 72 forms an acute angle with the plane where the first connecting segment 71 and the third connecting segment 73 are located. It can be understood that the inclination directions of multiple second connecting segments 72 are consistent. In the stored state, the second connecting segment 72 is stretched and parallel or approximately parallel to the axial direction of the left atrial appendage occluder. In the released state, the second connecting segment 72 drives the occluding disk 10 and the fixing disk 20 to perform a certain degree of circular motion, so that the horn hook structure 130 obliquely penetrates the pectinate muscle, further improving the reliability of fixation.

[0070] In another embodiment of the present application, Figure 12 to Figure 14 As shown, the difference from the first embodiment is that the first connecting segment 71 and the third connecting segment 73 in the first embodiment are all arc-shaped, while the first connecting segment 71 and the third connecting segment 73 in this embodiment have multiple arc-shaped bends, the second support rod 80 connects two adjacent first connecting segments 71, and the third support rod 90 connects two adjacent third connecting segments 73, which play a supporting role and stabilize the shape of the occluding disk 10 and the fixed disk 20. Different from the first embodiment, this embodiment does not shrink by the internal rotation of the overall petal-shaped structure, but the first connecting segment 71 and the third connecting segment 73 deform inward to achieve disk shrinkage. When the left atrial appendage occluder is subjected to a large range of radial compression, each first connecting segment 71 of the fixed disk 20 and each third connecting segment 73 of the occluding disk 10 are uniformly stressed, and the second support rod 80 and the third support rod 90 do not produce a large deformation. The radial compression is converted into axial deformation by the bending deformation of the first connecting segment 71 and the third connecting segment 73, which increases the adaptability range to the left atrial appendage size.

[0071] like Figures 2 to 4 , Figures 8 to 9 as well as Figure 12 to Figure 13 As shown, the left atrial appendage occluder further includes a third connector 110, which is detachably connected to the second connector 100 and is used to be connected to a delivery cable of the left atrial appendage occluding device.

[0072] Specifically, the third connecting member 110 and the second connecting member 100 are interference fit, the baffle film 30 is located between the second connecting member 100 and the second connecting member 100, the center of the baffle film 30 coincides with the center of the second connecting member 100, and the inner edge of the baffle film 30 is coated with structural adhesive, and the baffle film 30 is fixed by the structural adhesive on the baffle film 30 when the second connecting member 100 and the third connecting member 110 are matched.

[0073] In this embodiment, the third connecting member 110 is a connecting nut, the third connecting member 110 is threadedly connected to the second connecting member 100 , and the third connecting member 110 is fixedly connected to the elastic member 50 .

[0074] Specifically, Figure 4 As shown, a first connection seat 51 and a second connection seat 52 are respectively provided at both ends of the elastic member 50 , the first connection seat 51 and the part of the third connection member 110 extending into the second connection member 100 are welded and fixed, and the second connection seat 52 is connected to multiple control lines 60 .

[0075] like Figure 1 , Fig.10 as well as Fig.14 As shown, a connecting piece 31 is provided at the edge of the blocking film 30 . There are multiple connecting pieces 31 . The multiple connecting pieces 31 are arranged at intervals along the circumference of the blocking film 30 . The multiple control lines 60 are respectively connected to the multiple connecting pieces 31 .

[0076] Specifically, each first support rod 70 corresponds to a connecting piece 31 . By providing the connecting piece 31 , the connection firmness between the control line 60 and the flow-blocking membrane 30 can be improved to avoid damage to the flow-blocking membrane 30 .

[0077] The present invention also provides a left atrial appendage occluding device, comprising a delivery cable, a delivery sheath and the above-mentioned left atrial appendage occluding device, wherein the left atrial appendage occluding device is accommodated in the delivery sheath, and the delivery cable is detachably connected to the left atrial appendage occluding device.

[0078] Specifically, the delivery cable is threadedly connected to the third connecting piece 110. When releasing, the delivery cable moves distally along the axial direction of the delivery sheath, or the delivery sheath moves proximally, so that the fixing plate 20 of the left atrial appendage occluder enters the left atrial appendage first. If it is found that the release position is inappropriate or the release form, fixing effect, and occluding effect are not ideal during the release process, the left atrial appendage occluder can be recovered by moving the delivery cable or the delivery sheath, and released again after adjustment, thereby reducing the difficulty of the operation.

[0079] From the above description, it can be seen that the above-mentioned embodiments of the present invention achieve the following technical effects: the left atrial appendage occluder includes an occluding disk 10 and a fixed disk 20, a baffle 30, a first connecting member 40, an elastic member 50 and a control line 60, the fixed disk 20 is connected to the occluding disk 10, the baffle 30 is movably arranged on the outer surface of the occluding disk 10, the first connecting member 40 is arranged on the fixed disk 20 and is located at the center of the fixed disk 20, the elastic member 50 is arranged on the occluding disk 10, the elastic member 50 is coaxially arranged with the first connecting member 40, one end of the control line 60 is connected to the edge of the baffle 30, and the other end passes through the first connecting member 40 and is connected to the elastic member 50, so as to tension the baffle 30 under the elastic force of the elastic member 50, By arranging an elastic member 50 on the occluding disk 10, the baffle membrane 30 is movably arranged on the occluding disk 10, one end of the control line 60 is connected to the baffle membrane 30, and the other end passes through the first connecting member 40 arranged on the fixed disk 20 and is connected to the elastic member 50. When the occluding disk 10 and the fixed disk 20 are squeezed and deformed by the inner wall of the left atrial appendage, the elastic member 50 is used to shrink and pull the control line 60 to tighten the baffle membrane 30, so that the baffle membrane 30 moves along the occluding disk 10 and always remains flat on the surface of the occluding disk 10, thereby increasing the adaptability of the left atrial appendage occluder to left atrial appendages of different sizes, avoiding the setting of left atrial appendage occluders of various specifications, reducing the difficulty of users in selecting instruments of appropriate specifications, and improving the applicability of the left atrial appendage occluder.

[0080] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0081] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the numbers used in this way can be interchanged where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0082] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A left atrial appendage occluder, characterized in that: include: A blocking disk (10) and a fixing disk (20), wherein the fixing disk (20) is connected to the blocking disk (10); A flow-blocking film (30), the flow-blocking film (30) being movably arranged on the outer surface of the blocking disk (10); a first connecting member (40), the first connecting member (40) being arranged on the fixing plate (20) and located at a central position of the fixing plate (20); an elastic member (50), the elastic member (50) being arranged on the sealing disk (10), the elastic member (50) being coaxially arranged with the first connecting member (40); a control line (60), one end of the control line (60) being connected to the edge of the flow-blocking membrane (30), and the other end of the control line (60) passing through the first connecting member (40) and connected to the elastic member (50), so as to tension the flow-blocking membrane (30) under the elastic force of the elastic member (50); There are a plurality of control lines (60), and the plurality of control lines (60) are arranged at intervals along the circumference of the flow-blocking film (30).

2. The left atrial appendage occluder according to claim 1, characterized in that: The left atrial appendage occluder comprises a first support rod (70) and a second support rod (80), wherein the first support rod (70) and the second support rod (80) are both multiple, and the multiple first support rods (70) are arranged at intervals along the circumference of the occlusion disk (10), one end of the first support rod (70) is connected to the first connecting member (40), and the two ends of each second support rod (80) are respectively connected to two adjacent first support rods (70), and at least a portion of the first support rod (70), the second support rod (80) and the first connecting member (40) form the fixed disk (20).

3. The left atrial appendage occluder according to claim 2, characterized in that: The first support rod (70) comprises a first connecting section (71), a second connecting section (72) and a third connecting section (73); two ends of each second support rod (80) are respectively connected to two adjacent first connecting sections (71); a plurality of first connecting sections (71) are respectively connected to the first connecting member (40); the first connecting section (71), the second connecting section (72), the second support rod (80) and the first connecting member (40) form the fixed plate (20).

4. The left atrial appendage occluder according to claim 3, characterized in that: The left atrial appendage occluder further comprises: a third support rod (90), wherein there are a plurality of third support rods (90), and both ends of each third support rod (90) are respectively connected to two adjacent third connecting sections (73); A second connecting member (100), a plurality of the third connecting sections (73) are respectively connected to the second connecting member (100), the first connecting member (40) and the second connecting member (100) are coaxially arranged, and the third connecting sections (73), the third support rods (90) and the second connecting member (100) form the sealing disk (10).

5. The left atrial appendage occluder according to claim 4, characterized in that: The first connecting section (71), the third connecting section (73), the second supporting rod (80) and the third supporting rod (90) are all arc-shaped. Two adjacent first connecting sections (71) and one second supporting rod (80) form a petal-shaped structure; and / or Two adjacent third connecting sections (73) and one third supporting rod (90) form a petal-shaped structure.

6. The left atrial appendage occluder according to claim 5, characterized in that: The first connecting section (71) and the third connecting section (73) are both arc-shaped as a whole; or The first connecting section (71) and the third connecting section (73) both have multiple arc-shaped bends.

7. The left atrial appendage occluder according to claim 3, characterized in that: The second connecting section (72) has a bent ox-horn hook structure (130) for connecting to the inner wall of the left atrial appendage, and the ox-horn hook structure (130) has rounded edges.

8. The left atrial appendage occluder according to claim 7, characterized in that: There are a plurality of the horn hook structures (130), and the plurality of horn hook structures (130) are arranged at intervals along the extension direction of the second connecting section (72).

9. The left atrial appendage occluder according to claim 3, characterized in that: The second connecting section (72) is arranged parallel to or at an angle to the axial direction of the left atrial appendage occluder.

10. The left atrial appendage occluder according to claim 4, characterized in that: The left atrial appendage occluder further comprises a third connecting member (110), wherein the third connecting member (110) is detachably connected to the second connecting member (100) and is used to be connected to a delivery cable of the left atrial appendage occluding device.

11. The left atrial appendage occluder according to claim 10, characterized in that: The first connecting member (40) and the second connecting member (100) are connecting rings, the third connecting member (110) is a connecting nut, the third connecting member (110) is threadedly connected to the second connecting member (100), and the third connecting member (110) is fixedly connected to the elastic member (50).

12. The left atrial appendage occluder according to claim 2, characterized in that: The left atrial appendage occluder further comprises a guide member (120), wherein the guide members (120) are multiple, and the multiple guide members (120) are arranged at intervals on the first support rod (70), and the control line (60) is passed through the multiple guide members (120).

13. The left atrial appendage occluder according to claim 1, characterized in that: A connecting piece (31) is provided at the edge of the flow-blocking membrane (30), and the connecting piece (31) is multiple, and the multiple connecting pieces (31) are arranged at intervals along the circumference of the flow-blocking membrane (30), and the multiple control lines (60) are respectively connected to the multiple connecting pieces (31).

14. A left atrial appendage occlusion device, characterized in that: It comprises a delivery steel cable, a delivery sheath and a left atrial appendage occluder according to any one of claims 1 to 13, wherein the left atrial appendage occluder is accommodated in the delivery sheath, and the delivery steel cable is detachably connected to the left atrial appendage occluder.

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