Mild exfoliating and brightening composition and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a mild stripping and brightening composition and application thereof. Specifically, a protease aqueous solution, probiotic fermented brown algae and panthenol are compounded to prepare the composition; the composition is used as a main effective component to prepare skin care cosmetics. Experiments prove that the skin-care composition can effectively recover the micro-ecological balance of the skin, has the effect of brightening the skin, and has the advantages of stronger stripping effect, more obvious stripping effect and milder property compared with the conventional acid stripping component salicylic acid, so that the skin-care composition has good practical application value.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a mild exfoliating and brightening composition and application thereof. Background Art

[0002] The information disclosed in the background of the invention is only intended to enhance the understanding of the overall background of the invention and should not be necessarily regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to a person skilled in the art.

[0003] Salicylic acid is an extract from the bark of the plant willow. It is a fat-soluble hydroxy acid and also a natural anti-inflammatory drug (the commonly used drug aspirin is a derivative of salicylic acid, sodium acetylsalicylate). As a fat-soluble substance, salicylic acid can penetrate into the pores rich in lipids, and can fight against acne problems caused by excessive oil secretion. It can also be used to remove excess skin keratin and help the skin restore smoothness. Salicylic acid is not as irritating as other acidic substances such as fruit acid. This is because the human keratin itself is rich in lipids. The fat-soluble properties of salicylic acid can fuse with the lipids in the stratum corneum and penetrate into the stratum corneum and deep into the pores without irritating the dermis. The effect is locked in the shallow keratin and will not affect the active epidermal cells. It has high stability and low irritation.

[0004] Although salicylic acid is relatively mild compared to other acid ingredients, in actual use, people with sensitive skin are still troubled by its irritation when using salicylic acid products. Excessive use of salicylic acid even aggravates the already sensitive skin barrier. Therefore, developing an ingredient / composition that can replace salicylic acid to achieve gentle exfoliation without damage or even brightening and repairing is an urgent problem to be solved in this field. Summary of the invention

[0005] In view of the deficiencies of the prior art, the present invention provides a mild exfoliating and brightening composition and its application. Specifically, the present invention prepares a composition by compounding a protease aqueous solution, probiotic fermented brown algae and panthenol; then the composition is used as the main active ingredient to prepare a skin care cosmetic. It has been verified by experiments that it can effectively restore the microecological balance of the skin, while having the effect of brightening the skin, and compared with the conventional acid exfoliating ingredient salicylic acid, its exfoliating effect is stronger, has a more obvious exfoliating effect and is gentler. Based on the above research results, the present invention is completed.

[0006] In order to achieve the above technical objectives, the technical solution provided by the present invention is as follows:

[0007] The first aspect of the present invention provides a mild exfoliating and brightening composition, the composition comprising the following components in parts by weight:

[0008] 0.01-10 parts of protease aqueous solution, 0.1-30 parts of probiotic fermented brown algae, and 0.01-5 parts of panthenol.

[0009] The protease content in the protease aqueous solution is 0.1-1.5%, preferably 1%; further, the protease is serine protease, and further is keratinase.

[0010] The probiotic fermented brown algae is obtained by fermentation with multiple food-grade probiotics. In a specific embodiment of the present invention, the probiotic fermented brown algae is a seaweed fermentation liquid obtained by the fermentation method in CN 108653059 A. The brown algae is kelp. It should be noted that the probiotic fermented brown algae (seaweed fermentation liquid) does not contain live bacteria.

[0011] In another specific embodiment of the present invention, the composition comprises the following components in parts by weight:

[0012] 1 part of protease aqueous solution, 6 parts of probiotic fermented brown algae, 2 parts of panthenol.

[0013] The second aspect of the present invention provides use of the above composition in preparing cosmetics.

[0014] The cosmetic has at least one or more of the following functions:

[0015] (a) Skin barrier repair;

[0016] (b) Brighter skin;

[0017] (c) Balance the skin microecology.

[0018] The third aspect of the present invention provides a cosmetic having the effects of barrier repair, brightening, and balancing skin microecology, wherein the cosmetic comprises at least the above composition. More specifically, the cosmetic can be a skin care product.

[0019] According to the cosmetic of the present invention, the composition is added in an amount of 0.5-15%, preferably 2-10%, such as 2%, 3%, 5%, 7%, 8%, 9% or 10%, based on the total mass of the cosmetic.

[0020] The cosmetics may also contain any other raw material ingredients permitted to be added in the cosmetics field, including but not limited to emulsifiers, emollients, moisturizers, thickeners, preservatives, and the like.

[0021] At the same time, the present invention can also prepare different cosmetic dosage forms, such as water-based preparations, emulsions, ointments (creams), etc., by reasonably adding the above-mentioned raw material ingredients. At the same time, based on the above-mentioned basic cosmetic categories, other cosmetic categories such as facial cleansers, facial creams, lotions, facial masks, etc. are further derived and prepared, which are not specifically limited here.

[0022] A fourth aspect of the present invention provides a method for preparing the above-mentioned cosmetics, the method comprising the step of mixing the composition with other raw material components.

[0023] Beneficial technical effects of one or more of the above technical solutions:

[0024] (1) The mild exfoliating and brightening composition obtained by the above technical solution has a certain barrier repair effect, can promote FLG gene expression, and has a certain synergistic effect between the components;

[0025] (2) Compared with conventional acid peeling ingredients such as salicylic acid, the composition obtained by the above technical solution not only does not destroy the microecological balance of facial skin, but can also restore the balance of microecology. In addition, the inventors unexpectedly discovered that the composition of the present invention can also promote certain specific bacterial flora to produce specific metabolites, thereby further brightening the skin tone, achieving multiple effects, thereby reducing product costs;

[0026] (3) Compared with the conventional acid exfoliating ingredient salicylic acid, it has a stronger exfoliating effect, more obvious exfoliating effect and is gentler. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The accompanying drawings in the specification, which constitute a part of the present invention, are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention.

[0028] Figure 1 This is a test of the inhibitory effects of different samples of the present invention on Staphylococcus epidermidis.

[0029] Figure 2 The results of the test on exfoliated keratinocytes of the aqueous solution of the composition of Example 1 of the present invention are shown. DETAILED DESCRIPTION

[0030] It should be noted that the following detailed descriptions are all illustrative and intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present invention belongs.

[0031] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0032] The present invention is further described in conjunction with specific examples. The following examples are only for explaining the present invention and are not intended to limit the content thereof. If the specific experimental conditions are not specified in the examples, they are usually carried out according to conventional conditions or the conditions recommended by the reagent company; the reagents and consumables used in the following examples, unless otherwise specified, can all be obtained from commercial sources.

[0033] The present invention is further explained by the following examples, but it does not constitute a limitation of the present invention. It should be understood that these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention. The test methods in the following examples that do not specify specific conditions are usually carried out under conventional conditions. The protease (keratinase) aqueous solution (1%) in the examples and comparative examples of the present invention was purchased from Givaudan Daily Flavors and Fragrances (Shanghai) Co., Ltd. The probiotic fermented brown algae is the seaweed fermentation broth obtained by the preparation method of Example 1 of CN 108653059A. Salicylic acid inclusion complex was purchased from Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. Panthenol was purchased from BASF (China) Co., Ltd.

[0034] The specific compositions of Examples 1 to 6 are as follows:

[0035]

[0036]

[0037] The specific compositions of Comparative Examples 1 to 8 are as follows:

[0038]

[0039] Application Example 1 Preparation of Lotion

[0040] Phase A (parts by weight): 4 parts of glycerol, 4 parts of butylene glycol, 0.4 parts of fenvalerate, 0.4 parts of hexylene glycol, 0.05 parts of EDTA2Na, and deionized water To 100;

[0041] Phase B: 1 part of protease aqueous solution (1%), 6 parts of probiotic fermented brown algae, 2 parts of panthenol

[0042] The steps for preparing the above lotion are as follows:

[0043] 1) Add glycerol, butylene glycol, quinone, hexylene glycol, EDTA2Na and deionized water into a beaker, heat and stir in a 65°C water bath to fully dissolve them, and obtain phase A;

[0044] 5) When the emulsion temperature drops to 40-45°C, add phase B into the system and stir at 40r / min to cool down;

[0045] 6) When the temperature dropped to 38°C, the mixture was cooled to obtain a lotion containing the composition of Example 1.

[0046] Application Example 2 Emulsion Preparation

[0047] Phase A (parts by weight): 1 part of A165 (emulsifier), 3 parts of GTCC, 3 parts of white oil, 0.5 parts of cetostearyl alcohol, and 5 parts of silicone oil;

[0048] Phase B (parts by weight): 4 parts of glycerol, 4 parts of butylene glycol, 0.4 parts of EMT-10 (thickener), 0.1 parts of xanthan gum, 0.4 parts of cinnamone, 0.4 parts of hexylene glycol, 0.2 parts of soy lecithin, and 100 parts of deionized water;

[0049] Phase C: 1 part of protease aqueous solution (1%), 6 parts of probiotic fermented brown algae, and 2 parts of panthenol.

[0050] The above emulsion preparation steps are as follows:

[0051] 1) Disperse EMT-10, xanthan gum and soybean lecithin into glycerol and butylene glycol, then add fenvalerate, hexylene glycol and deionized water, heat and stir in a water bath at 80°C to fully dissolve, and obtain phase B;

[0052] 2) A165, GTCC, white oil, cetostearyl alcohol, and silicone oil were heated and melted in a water bath at 83° C. to obtain phase A;

[0053] 3) Heat phase A and phase B in a water bath at 83°C at the same time. When the two phases are at the same temperature, slowly add phase A to phase B while stirring phase B at 500 r / min.

[0054] 4) After phase B and phase A are mixed, the emulsion is cooled down under stirring conditions at 430 r / min;

[0055] 5) When the emulsion temperature drops to 40-45°C, add phase C into the system and stir at 60r / min to cool down;

[0056] 6) When the temperature dropped to 38°C, the mixture was cooled to obtain an emulsion containing the composition of Example 1.

[0057] Experimental Example 1 In vitro repair efficacy test

[0058] (I) Cell inoculation: After the cells are revived, when the plating rate reaches about 60%, the cells are inoculated into a 6-well plate and incubated overnight in a CO2 incubator (37°C, 5% CO2).

[0059] (ii) Liquid preparation: Prepare the working solution of the test substance according to the test groups.

[0060]

[0061]

[0062] Note: The aqueous solutions of Examples 1 to 6 and Comparative Examples 1 to 8 were supplemented with water to 100 g.

[0063] (III) Administration: According to the test grouping, when the cell plating rate in the 6-well plate reaches 40% to 60%, group administration is carried out, and 3 replicate wells are set up for each group. 2 mL of culture medium is added to each well of the blank control group, 2 mL of culture medium containing WY14643 is added to each well of the positive control group, and 2 mL of culture medium containing the corresponding concentration of the sample to be tested is added to each well of the sample group. After the administration is completed, the 6-well plate is placed in a CO2 incubator (37°C, 5% CO2) and cultured for 24 hours.

[0064] (IV) Collect cells: After incubation, discard the old solution, wash twice with PBS, add 1 mL of RNAiso Plus to each well, pipette and lyse the cells, and collect the samples.

[0065] (V) Gene expression detection: RNA was extracted and reverse transcribed into cDNA, followed by fluorescence quantitative PCR detection, and the results were calculated using the 2-△△CT method.

[0066] (VI) Calculation of the increase rate:

[0067] (VII) FLG gene test results

[0068] Serial number Group Upward adjustment rate (vs BC) Significance 1 Blank group (BC) / / 2 Positive Control (PC) 28.00％ ** 3 Example 1 Composition aqueous solution 88.10％ ** 4 Example 2 Composition aqueous solution 72.24％ ** 5 Example 3 Composition aqueous solution 90.56％ ** 6 Example 4 Composition Aqueous Solution 96.25％ ** 7 Example 5 Composition Aqueous Solution 112.76％ * 8 Example 6 Composition Aqueous Solution 98.63％ ** 9 Comparative Example 1 Composition Aqueous Solution 23.86％ ** 10 Comparative Example 2 Composition Aqueous Solution 50.16％ * 11 Comparative Example 3 Composition Aqueous Solution 41.16％ * 12 Comparative Example 4 Composition Aqueous Solution 15.75％ ** 13 Comparative Example 5 Composition Aqueous Solution 10.25％ * 14 Comparative Example 6 Composition Aqueous Solution 20.16％ ** 15 Comparative Example 7 Composition Aqueous Solution 22.46％ ** 16 Comparative Example 8 Composition Aqueous Solution 1.02％ /

[0069] Note: Compared with the BC group, significance is indicated by *, P-value < 0.05 is indicated by *, P-value < 0.01 is indicated by **

[0070] Experimental Example 2 Staphylococcus epidermidis (ATCC12228) test

[0071] 1) Culture medium configuration: TSB liquid culture medium: 1.5% (g / 100ml) tryptone, 0.5% (g / 100ml) soy peptone, 0.5% (g / 100ml) sodium chloride, the remainder is distilled water, and the pH value is adjusted to 7.2±0.2. Pressure steam sterilization is performed at 121°C for 20 minutes. TSB solid culture medium: 2% (g / 100ml) agar powder is added to the above culture medium.

[0072] 2) Recovery of bacterial strains: Aseptically pipette a small amount of thawed Staphylococcus epidermidis and drop it near one edge of the solid culture medium. Inoculate the culture medium by streak method and incubate it inverted in a 37°C incubator for 24 hours.

[0073] 3) Preparation of bacterial suspension: Use a sterile pipette tip to pick a single colony from the solid culture medium and place it in 1 mL of liquid culture medium. Incubate it in a 37°C constant temperature oscillator (200 rpm) for 24 h. Determine the concentration of the bacterial suspension by dilution method to obtain 1×10 6 CFU / mL.

[0074] 4) Sample culture: Add 720 μL of liquid culture medium, 8 μL of bacterial suspension, and 180 mg of sample to a 1.5 mL centrifuge tube under sterile operation and mix well. Replace the sample with saline in the blank control group. Perform 3 parallel experiments for each sample and culture all samples in a 37°C constant temperature oscillator (200 r / min) for 24 h.

[0075]

[0076] 5) Determination of bacterial count by dilution method: Take the sample to be tested out of the oscillator, take 20 μL of the sample to be tested, add 180 μL of liquid culture medium, mix well, this is a 10-fold dilution. Take 20 μL of the diluent, add 180 μL of liquid culture medium, mix well, this is a 10-fold dilution. 2 times, and dilute to 10 5 Pour the solid culture medium into a plate and mark it. 2 ~10 5 Take 5 μL of each sample to be tested and drop it into the corresponding position of the plate, incubate it upside down at 37℃ for 24 hours, and observe the growth of bacteria.

[0077] Depend on Figure 1 It can be seen that compared with the blank group No. 1, sample No. 15 (only salicylic acid component added) has a certain inhibitory effect on Staphylococcus epidermidis, and compared with No. 2 and No. 14, sample No. 14 (composition with salicylic acid added) has a certain inhibitory effect on Staphylococcus epidermidis. The samples provided by the present invention can promote the proliferation of Staphylococcus epidermidis, and the proliferation efficiency is higher than that of single or two-by-two compound use, which is more conducive to the balance of skin microecology.

[0078] Experimental Example 3 Evaluation of 3D Melanin Skin Model

[0079] (1) Experimental instruments and materials: Mela 3D melanin skin model, batch number: EM221201, Guangdong Boxi Biotechnology Co., Ltd.; MelaGrowth melanocyte culture medium, batch number: 230621, Guangdong Boxi Biotechnology Co., Ltd.; α-arbutin, 100 g / bag, Guangzhou Tingnan Biotechnology Co., Ltd.; phosphate buffered saline (PBS), Gibco; sodium hydroxide, Guangzhou Chemical Reagent Factory; dimethyl sulfoxide, Sinopharm Chemical Reagent Co., Ltd.; biological safety cabinet, NUNRE; carbon dioxide incubator, SHELLLAB, USA; colorimeter, Minolta; multifunctional microplate reader, Thermo Fisher; constant temperature water bath, Shanghai Yiheng Scientific Instrument Co., Ltd.

[0080] (2) Experimental methods

[0081] ① Test substance: The survival rate of B16-F10 mouse melanoma cells in Experimental Examples 1 to 7 and Comparative Experimental Examples 1 to 8 for 24 hours was not less than 92% (no cytotoxicity under the experimental concentration conditions), and 1 ml of the sample was taken, and the solvent was the melanocyte culture medium Mela Growth.

[0082] ② Skin model preparation: The day the skin model was received was defined as DAY 0, and a 6-well plate was prepared. 0.9 mL of resuscitation solution (melanocyte culture medium MelaGrowth) was added to each well. The qualified model was transferred to the 6-well plate with sterile tweezers and cultured in an incubator at 37°C, 5% CO2, and 95% relative humidity for 1 hour. After incubation, the resuscitation solution was discarded and replaced with the same volume of resuscitation solution, and cultured overnight.

[0083] ③ Sampling and detection: 33 skin models were subjected to natural melanization, and a model group and a sample group were set up. The model group had 3 skin models without treatment, and the sample group had 30 skin models. Three parallel skin models were set up at each detection point, and the test results were averaged. Except for the model group, 1 ml of each of Experimental Examples 1 to 3 and Comparative Experimental Examples 1 to 7 was continuously applied to the surface of the sample group every day, with a daily action time of 24 hours for 3 days, and the melanocyte culture medium MelaGrowth was replaced every day. Three skin models from the model group and 30 skin models from the sample group were taken for detection.

[0084] ④ Determination of melanin content: Place the skin model in a 1.5mL centrifuge tube, add 1mL of PBS buffer, vortex for 3min, discard the liquid, add 1mL of 1mol / L NaOH solution containing 10% DMSO to the 1.5mL centrifuge tube, place in a 80℃ water bath for 40min, mix well and pipette 200μL into a 96-well plate, and read the absorbance value at a wavelength of 405nm using an enzyme reader.

[0085] Table 1: Melanin content results

[0086]

[0087] Note: **Compared with the model group, P<0.01.

[0088] The results of melanin content on the third day are shown in Table 1. Compared with the model group, the composition of the present invention has a significant effect on melanin inhibition compared with single components and two-by-two compound components, and has a certain synergistic whitening effect.

[0089] Experimental Example 4 In vitro exfoliation efficacy test

[0090] (I) Test Grouping

[0091]

[0092] (II) Drug administration

[0093] 1) Fix the skin between the supply chamber and the receiving chamber of the Franz cell diffusion pool, with the stratum corneum facing the supply chamber and the dermis facing the receiving chamber; add 7.0 mL of receiving solution into the receiving chamber, tighten and fix the ex vivo skin tissue, add 1.0 mL of receiving solution (PBS) into the receiving chamber through a sampler, exhaust the air, and make the dermis layer of the skin in close contact with the receiving solution.

[0094] 2) Add the sample to the skin surface in the donor chamber, add 50 μL of the sample to the surface of the ex vivo skin tissue (PBS buffer was added to the surface of the control group as a blank control), and spread the sample evenly from the center of the skin to the edge in a radial direction, with the sample exposure area of ​​3.14 cm2. Each sample was repeated 3 times in parallel, and a constant temperature water bath of (32±1)℃ was maintained, and there were no bubbles in the water bath interlayer.

[0095] 3) After incubation for 24 hours, put on a finger cot and rub the sample application area. After rubbing for 2 minutes, add 0.5 mL of cleaning solution (0.1% Triton X-100) to the supply chamber and blow to clean the keratinocytes shed from the skin surface.

[0096] 4) Transfer the cleaning solution to a 1.5 mL centrifuge tube for later use.

[0097] (III) Microscopic photography of exfoliated keratinocytes

[0098] 1) Vortex the washed keratinocyte suspension to mix well, use a pipette to draw 10 μL of keratinocyte suspension and drop it in the center of the adhesive slide, and spread the drop with the pipette tip.

[0099] 2) Place the slide on an automatic slide baking machine, set the baking temperature to 50°C, and bake for 10 minutes to dry the liquid and fix the keratinocytes on the slide.

[0100] 3) Add sodium fluorescein staining solution onto the slide glass, allowing the staining solution to evenly cover the smear. Stain for 10 minutes at room temperature in the dark.

[0101] 4) After staining, rinse with PBS until the water is colorless. Then put the slide into the cleaning box and wash with PBS twice, 5 minutes each time.

[0102] 5) Add an appropriate volume of anti-fluorescence quencher onto the smear and seal the slide.

[0103] 6) Place the slide under a fluorescence microscope and take photos under a 20× objective lens.

[0104] (IV) Total protein content detection

[0105] 1) Place the collected washing solution in a high-speed centrifuge, adjust the speed to 15,000 rpm, centrifuge for 10 minutes, precipitate the keratinocytes in the washing solution, discard the supernatant, and resuspend the precipitate with 0.5 mL of deionized water.

[0106] 2) Add 25 μL of sodium hydroxide (12 M) solution to the resuspended liquid, boil in a boiling water bath for 30 min to lyse the keratinocytes, and add 25 μL of concentrated hydrochloric acid (12 M) to neutralize the lysate.

[0107] 3) Detect the total protein content according to the instructions of the BCA protein assay kit.

[0108] (V) Calculation of promotion rate:

[0109] (VI) Test results

[0110] 1) Exfoliated keratinocyte test results

[0111] The results are as follows Figure 2 As shown, the more fluorescent green, the more detached keratinocytes. Compared with the BC group, the number of detached keratinocytes in the PC group and the aqueous solution of Example 1 increased significantly, indicating that both the PC group and the aqueous solution of Example 1 can promote the shedding of keratinocytes and have an exfoliating effect. At the same time, the number of detached keratinocytes in the aqueous solution of Example 1 is significantly higher than that in the PC group, which indicates that the aqueous solution of Example 1 provided by the present invention has a better exfoliating effect than salicylic acid.

[0112] 2) Total protein content test results

[0113]

[0114] Note: When the t-test method was used for statistical analysis, the significance was indicated by *, P-value < 0.05 was indicated by *, and P-value < 0.01 was indicated by ** compared with the BC group.

[0115] Compared with the BC group, the total protein content of the aqueous solution of Example 1 increased significantly. Based on the ex vivo pig skin, compared with the control group, the total protein content of the aqueous solution of Example 1 increased significantly, indicating that the number of detached keratinocytes increased significantly, indicating that the sample can promote the shedding of keratinocytes, has an exfoliating effect, and its exfoliation ability is better than salicylic acid.

[0116] The above embodiments are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with the technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A mild exfoliating and brightening composition, characterized in that: The composition comprises the following components in parts by weight: 0.01-10 parts of protease aqueous solution, 0.1-30 parts of probiotic fermented brown algae, and 0.01-5 parts of panthenol.

2. The composition according to claim 1, characterized in that The protease content in the protease aqueous solution is 0.1-1.5%; the protease is serine protease, and further is keratinase.

3. The composition according to claim 1, characterized in that The probiotic fermented brown algae is obtained by fermentation with multiple food-grade probiotics; further, the probiotic fermented brown algae is a seaweed fermentation liquid obtained by the fermentation method in CN 108653059A.

4. The composition according to claim 1, characterized in that The brown algae is kelp.

5. The composition according to any one of claims 1 to 4, characterized in that The composition comprises the following components in parts by weight: 1 part of protease aqueous solution, 6 parts of probiotic fermented brown algae, 2 parts of panthenol.

6. Use of the composition according to any one of claims 1 to 5 in the preparation of cosmetics.

7. The use according to claim 6, characterized in that The cosmetic has at least one or more of the following functions: (a) Skin barrier repair; (b) Brighter skin; (c) Balance the skin microecology.

8. A cosmetic with the effects of barrier repair, brightening, and balancing skin microecology, characterized in that: The cosmetic comprises at least the composition according to any one of claims 1 to 5.

9. The cosmetic according to claim 8, characterized in that The cosmetics are skin care products.

10. The method for preparing the cosmetic according to claim 8 or 9, characterized in that: The preparation method comprises the step of mixing the composition with other raw material components.

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