Filtering structure and filtering method for filtering structure

Abstract

One or more embodiments of the invention relate to a filtering structure and a filtering method for the filtering structure. The filtering structure comprises at least one filtering layer and at least one circulation layer arranged along the filtering direction of the filtering layer; the circulation layer comprises at least one first supporting piece and at least one first flow channel, the first flow channel is used for allowing to-be-filtered liquid to flow through, and the first flow channel and the first supporting piece are arranged in a spaced mode.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to Chinese patent application No. 202310834071.0 filed on July 7, 2023, the entire contents of which are incorporated herein by reference. Technical Field

[0002] The present specification relates to the field of biological instrument technology, and in particular to a filtering structure and a filtering method for the filtering structure. Background Art

[0003] Membrane separation technology refers to the process of separating and purifying liquids or gases using a filter membrane. The commonly used membranes for tangential flow filtration are mainly three categories: roll membrane, hollow fiber membrane and plate membrane. Membrane filtration technology is widely used in water treatment, food processing, biotechnology and other fields. However, there are problems in scaling up both roll membrane and hollow fiber membrane. The flow rate requirement of roll membrane is very large, the energy consumption is high, and the two ends of the roll membrane are prone to leakage. At present, the roll membrane technology in the biomedical field has been gradually eliminated; the advantage of hollow fiber membrane is that the shear force is small and the damage to cells is small, but the membrane filaments of hollow fiber membrane are easy to break, which is not conducive to industrial scale-up, and the types of membrane materials and filtration pore sizes are limited; the advantage of plate membrane is that there are many types of membrane materials and filtration pore sizes, and it is relatively easy to scale up industrially, but the structural characteristics of the filter membrane and the screen of plate membrane technology itself lead to relatively large shear force, which damages sensitive substances in the liquid to be filtered, thereby affecting the filtration efficiency and filtration effect. For example, sensitive substances such as cells in the liquid to be filtered are easily destroyed during filtration, thereby affecting cell activity.

[0004] In order to solve the above problems, this specification provides a filtration structure, which significantly reduces the damage to shear-sensitive substances in the liquid to be filtered through a straight-through flow channel technology with controllable equivalent diameter. At the same time, the filtration structure also has the advantages of hollow fiber membranes and flat membranes. Summary of the invention

[0005] One of the embodiments of the present specification provides a filtration structure, comprising at least one filtration layer and at least one circulation layer arranged along the filtration direction of the filtration layer; the circulation layer comprises at least one first support member and at least one first flow channel, the first flow channel is used for allowing the liquid to be filtered to flow through, and the first flow channel is spaced apart from the first support member.

[0006] One of the embodiments of the present specification provides a filtering method for a filtering structure, comprising: inputting a liquid to be filtered through an inlet end of the filtering structure; and collecting a retained liquid discharged from a retaining end of the filtering structure. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] This specification will be further described in the form of exemplary embodiments, which will be described in detail by the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same number represents the same structure, wherein:

[0008] Figure 1 is a cross-sectional schematic diagram of a filtering structure with a permeable layer according to some embodiments of the present specification;

[0009] Figure 2 is a schematic cross-sectional view of a filtering structure with a permeable layer according to other embodiments of the present specification;

[0010] Figure 3 is a schematic cross-sectional view of a filtering structure with a permeable layer according to some other embodiments of the present specification;

[0011] Figure 4 is a schematic cross-sectional view of a first support member according to other embodiments of the present specification;

[0012] Figure 5 is a schematic diagram of a structure in which a first support member is connected to a housing according to some embodiments of this specification;

[0013] Figure 6 yes Figure 5 A cross-sectional schematic diagram of

[0014] Figure 7 is a schematic diagram of a structure in which a second support member is connected to a housing according to some embodiments of this specification;

[0015] Figure 8 yes Figure 7 A cross-sectional schematic diagram of

[0016] Fig. 9 is a schematic diagram of the structure of the connection between the screen and the housing according to some embodiments of this specification;

[0017] Fig.10 yes Fig. 9 A cross-sectional schematic diagram of

[0018] Fig.11 is a cross-sectional schematic diagram of a filtering mechanism without a permeable layer according to some embodiments of the present specification;

[0019] Fig.12 is a cross-sectional schematic diagram of a filtering mechanism without a permeable layer according to other embodiments of the present specification;

[0020] Fig.13 is a cross-sectional schematic diagram of a filtering mechanism without a permeable layer according to some other embodiments of the present specification;

[0021] Fig.14 is a schematic cross-sectional view of a filtering structure according to other embodiments of the present specification;

[0022] Fig.15 yes Fig.14 A schematic diagram of the flow direction of the liquid to be filtered in the circulation layer of the filtration structure;

[0023] Fig.16 yes Fig.14 Schematic diagram of the flow direction of the leachate in the filter layer of the filter structure;

[0024] Fig.17 is a cross-sectional schematic diagram of a filtering structure according to some other embodiments of the present specification;

[0025] Fig.18 is a cross-sectional schematic diagram of a filtering structure according to some other embodiments of the present specification;

[0026] Fig.19 is a schematic diagram of the structure when the liquid distribution component shown in some embodiments of this specification is placed at a first angle;

[0027] Fig. 20 is a schematic diagram of the structure when the liquid distribution component shown in some embodiments of this specification is placed at a second angle;

[0028] Fig.21 is a schematic diagram of the structure of a liquid distribution component placed at a first angle according to other embodiments of the present specification;

[0029] Fig. 22 is a schematic diagram of the structure when the liquid distribution component is placed at a second angle according to other embodiments of the present specification;

[0030] Fig.23 is a simplified structural schematic diagram of a liquid dispensing component according to other embodiments of the present specification;

[0031] Fig.24 It is a simplified structural diagram of the liquid distribution component and the inlet end of the filter structure when they cooperate with each other according to some embodiments of the present specification. DETAILED DESCRIPTION

[0032] In order to more clearly illustrate the technical solutions of the embodiments of this specification, the following is a brief introduction to the drawings required for the description of the embodiments. Obviously, the drawings described below are only some examples or embodiments of this specification. For ordinary technicians in this field, this specification can also be applied to other similar scenarios based on these drawings without creative work. Unless it is obvious from the language environment or otherwise explained, the same reference numerals in the figures represent the same structure or operation.

[0033] As shown in this specification and claims, unless the context clearly indicates an exception, the words "a", "an", "an" and / or "the" do not refer to the singular and may also include the plural. Generally speaking, the terms "comprise" and "include" only indicate the inclusion of the steps and elements that have been clearly identified, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements.

[0034] The present specification provides a filtering structure, which at least includes a filtering layer and at least one circulation layer arranged along the filtering direction of the filtering layer, the circulation layer includes a first flow channel and a first support member, and the first flow channel and the first support member are arranged at intervals. After the liquid to be filtered is injected into the filtering structure, the liquid to be filtered can enter the filtering layer through the first flow channel, and then be filtered by the filtering membrane of the filtering layer. When the filtering membrane filters the liquid to be filtered, the first support member of the circulation layer can support the filtering membrane, establish one or more channels to guide the liquid to be filtered to flow through the surface of the filtering membrane, and utilize the rigidity of the first support member so that the first flow channel and the filtering membrane will not be significantly deformed during the entire filtering process, so that the path of the first flow channel can be well maintained, thereby making the resistance and disturbance of the liquid to be filtered smaller during the flow process, closer to the laminar flow state, greatly reducing the shear force on the liquid to be filtered, and significantly reducing the damage to the active substances in the liquid to be filtered, for example, reducing the damage to the cells in the liquid to be filtered, thereby improving the cell activity. In some embodiments, the extension direction of the first flow channel is parallel to the surface of the filter layer. When the liquid to be filtered flows from the first flow channel into the filter layer, on the one hand, the tangential flow can effectively avoid blockage of the filter layer (for example, the filter membrane of the filter layer). On the other hand, the first flow channel ensures that the shear force on the liquid to be filtered is very small, thereby greatly reducing damage to sensitive substances (such as cells, etc.), greatly improving the filtration efficiency, and significantly improving the filtration effect.

[0035] In some embodiments, Figure 1-Figure 3 As shown, the filter structure 100 may include at least one filter layer 110 and at least one flow layer 120 arranged along the filter direction of the filter layer 110. The flow layer 120 may include at least one first support member 121 and at least one first flow channel 122, the first flow channel 122 may be used for the liquid to be filtered to flow through, and the first flow channel 122 is spaced apart from the first support member 121.

[0036] The filtering direction of the filter layer 110 refers to the linear direction of the permeation direction of the liquid to be filtered along the filter layer 110, for example, it may include the permeation direction of the liquid to be filtered when entering the filter layer 110 and the permeation direction of the filtered liquid. Figure 1 It is represented by the Z-axis in .

[0037] In some embodiments, the filter structure 100 may further include a housing 130, and the circulation layer 120 and the filter layer 110 are both disposed in the housing 130. In some embodiments, the inlet end of the filter structure 100 is in communication with the circulation layer 120. In some embodiments, the inlet end of the filter structure 100 is disposed on the housing 130. In this embodiment, since the inlet end of the filter structure 100 is in communication with the circulation layer 120, the liquid to be filtered is injected into each first flow channel 122 of the circulation layer 120 through the inlet end of the filter structure 100, and flows along the extension direction of the first flow channel 122. Since at least one circulation layer 120 is disposed along the filtering direction of the filter layer 110, the liquid to be filtered can start filtering along the contact surface between each first flow channel 122 and the adjacent filter layer 110 during the process of flowing along the first flow channel 122. In addition, the first support member 121 can support the filter layer 110, establish one or more channels to guide the liquid to be filtered to flow through the surface of the filter layer 110, and utilize the rigidity of the first support member 121 to prevent the first flow channel 122 and the filter layer 110 from being significantly deformed during the entire filtering process, so that the path of the first flow channel 122 can be well maintained, thereby making the resistance and disturbance of the liquid to be filtered smaller during the flow process, closer to the laminar flow state, greatly reducing the shear force on the liquid to be filtered, and significantly reducing the damage to the active substances in the liquid to be filtered, for example, reducing the damage to the cells in the liquid to be filtered and improving the cell activity. In some embodiments, the interception end (not shown in the figure) of the filter structure 100 is connected to the circulation layer 120, and the intercepted liquid in the circulation layer 120 is discharged through the interception end. The intercepted liquid refers to the part of the liquid to be filtered that is trapped in the circulation layer 120 after entering the circulation layer 120. The liquid flowing from the circulation layer 120 into the filter layer 110 is the permeate.

[0038] In some embodiments, the housing 130 can be used to support other components of the filter structure 100. For example, the housing 130 can be used to fix the first support member 121 of the flow layer 120. For another example, the housing 130 can be used to fix the filter layer 110 (such as the screen 112 of the filter layer 110). For another example, the housing 130 can be used to fix the liquid distribution components described below (for example, Fig.19 and Fig. 20 In some embodiments, the material of the housing 130 may include resin, polyoxymethylene (POM), etc.

[0039] In some embodiments, the number of the first flow channel 122 is one, and the first flow channel 122 can be spaced apart from the first support member 121. In some embodiments, the number of the first flow channel 122 is multiple, and the multiple first flow channels 122 are spaced apart. In some embodiments, the multiple first flow channels 122 are spaced apart in parallel, and the multiple first flow channels 122 are parallel to the surface of the filter layer 110. The distribution direction of the multiple first flow channels 122 (i.e., the spacing direction of the multiple first flow channels 122) can be represented by the Y axis. In some embodiments, two adjacent first flow channels 122 are separated by the first support member 121. In some cases, since a first support member 121 is arranged between two adjacent first flow channels 122, each first flow channel 122 is relatively independent, and each first flow channel 122 can independently supply the flow of the liquid to be filtered. The liquid to be filtered in each first flow channel 122 will not affect each other, so that the liquid to be filtered in each first flow channel 122 is more uniform, which is more conducive to the tangential flow of the liquid to be filtered along the surface of the filter layer 110, thereby delaying the accumulation and concentration polarization of substances retained by the filter layer 110 on the surface of the filter layer 110, avoiding premature clogging of the filter layer 110, and improving the filtering effect.

[0040] In some embodiments, the extension direction of the first flow channel 122 can be parallel to the surface of the filter layer 110. When the liquid to be filtered flows into the filter layer 110 from the first flow channel 122, on the one hand, the tangential flow can effectively prevent the filter layer 110 from being blocked. On the other hand, the first flow channel 122 ensures that the shear force on the liquid to be filtered is very small, thereby greatly reducing the damage to sensitive substances (such as cells, etc.), greatly improving the filtration efficiency, and significantly improving the filtration effect.

[0041] In some embodiments, the first support member 121 may be provided with a first connecting hole (not shown in the figure). When the number of the first flow channels 122 is multiple, the first connecting hole of the first support member 121 may connect two adjacent first flow channels 122 so that the liquid in the adjacent first flow channels 122 can convect and diffuse.

[0042] In some embodiments, a flow layer 120 is provided in the filtering direction of the filter layer 110. Figure 1 In the illustrated embodiment, the number of the filter layer 110 and the number of the circulation layer 120 are both one, and the circulation layer 120 is disposed on one side of the filter layer 110 along the filtering direction of the filter layer 110. Figure 2In the illustrated embodiment, a filter layer 110 is provided on both sides of the circulation layer 120 in the thickness direction, that is, for each filter layer 110, the number of circulation layers 120 in the filtering direction of the filter layer 110 is one. In some embodiments, a plurality of circulation layers 120 are provided in the filtering direction of the filter layer 110. As an example only, a circulation layer 120 is provided on both sides of the filter layer 110 in the filtering direction. For example, Figure 1 The illustrated embodiment is modified by adding a flow layer 120 between the filter layer 110 and the permeable layer 140 .

[0043] In some embodiments, the number of the filter layer 110 can be multiple, and the filter layer 110 is provided on both sides of the flow layer 120 in the thickness direction. Figure 2 As shown, there are two filter layers 110, and one circulation layer 120, and one filter layer 110 is respectively arranged on both sides of the circulation layer 120 in the thickness direction. Since one filter layer 110 is respectively arranged on both sides of the circulation layer 120 in the thickness direction, the liquid to be filtered in each first flow channel 122 will be filtered by the contact surfaces of two adjacent filter layers 110 respectively, and the circulation layer 120 can support the filter layers 110 on both sides at the same time, thereby improving the filtering efficiency while ensuring the structural rigidity of the filter layers 110 on both sides, and further ensuring that the first flow channel 122 and the filter layer 110 will not be significantly deformed during the entire filtering process.

[0044] In some embodiments, the number of the circulation layer 120 may be multiple, and each circulation layer 120 is provided with a filter layer 110 on both sides in the thickness direction. Figure 3 As shown, there are multiple filter layers 110, multiple circulation layers 120, multiple circulation layers 120 are arranged at intervals along the filtering direction of the filter layer 110, and filter layers 110 are arranged on both sides of the thickness direction of each circulation layer 120. By providing multiple circulation layers 120, the number of first flow channels 122 can be increased, the volume of liquid to be filtered accommodated by the filter structure 100 is increased, and the filtering flux of the filter structure 100 is improved.

[0045] In some embodiments, the filter layer 110 may include one or more filter membranes 111, and the filter membranes 111 may be used to filter the liquid to be filtered. Figure 1 In the illustrated embodiment, the filter layer 110 may include one filter membrane 111. For another example, the filter layer 110 may include two filter membranes 111. In some embodiments, the extension direction of the first flow channel 122 is parallel to the surface of the filter layer 110, which means that the extension direction of the first flow channel 122 is parallel to the surface of the filter membrane 111.

[0046] In some embodiments, the filter membrane 111 may be a device for intercepting and separating macromolecules and small molecules or large particles and small particles. In some embodiments, the filter membrane 111 may only allow specific substances in the liquid to be filtered to pass through, and intercept other substances. In some embodiments, the filter membrane 111 is provided with filter holes with specific pore sizes. When the liquid to be filtered contacts the filter membrane 111, particulate matter, molecules (e.g., proteins) or tissues with a size larger than the pore size of the filter holes will be intercepted by the filter membrane 111 and cannot pass through the filter membrane 111, while particulate matter, molecules or tissues with a size smaller than the pore size of the filter holes can pass through the filter membrane 111 through the filter holes, thereby separating particulate matter, molecules or tissues with a size smaller than the pore size of the filter holes from particulate matter, molecules (e.g., proteins) or tissues with a size larger than the pore size of the filter holes. When the filter membrane 111 is combined with the circulation layer 120, particulate matter, molecules or tissues that cannot pass through the filter membrane 111 will be intercepted in the first flow channel 122. The particulate matter, molecules or tissues that pass through the filter membrane 111 will flow to other areas (eg, the permeable layer 140 hereinafter).

[0047] In some embodiments, if the circulation layer 120 is not provided, the liquid to be filtered will directly contact the filter membrane 111 and be filtered, and the substances in the liquid to be filtered that are smaller than the pore size of the filter membrane 111 will usually flow in a direction perpendicular to the surface of the filter membrane 111, that is, tangential flow filtration. When the liquid to be filtered flows tangentially, a certain pressure needs to be applied to the liquid to be filtered in order to push it through the filter pores of the filter membrane 111. When the driving force is too small, the driving force to push the liquid to be filtered through the filter pores of the filter membrane 111 is insufficient, resulting in insufficient transmembrane pressure (i.e., the pressure that causes the liquid to be filtered to pass through the filter membrane 111), and low filtration efficiency. When the driving force is too large, the liquid to be filtered may squeeze the filter membrane 111, causing the filter membrane 111 to deform, thereby affecting the shape of the circulation channel of the liquid to be filtered, and then affecting the shear force on the liquid to be filtered, as well as the filtration effect and filtration efficiency. In addition, since the extension direction of the first flow channel 122 is parallel to the surface of the filter membrane 111, when the liquid to be filtered flows in the first flow channel 122, it is equivalent to flowing along the surface of the filter membrane 111, which not only avoids the blockage of the filter membrane 111 caused by the tangential flow of the liquid to be filtered, but also enables the liquid to be filtered to fully contact the surface of the filter membrane 111, thereby increasing the contact area between the liquid to be filtered and the surface of the filter membrane 111, greatly improving the filtration efficiency, and significantly improving the filtration effect.

[0048] In some embodiments, the filter membrane 111 may include at least one of a hollow fiber membrane, a tubular membrane, a ceramic membrane, or a polymer membrane. In some embodiments, the filter membrane 111 may be a flat membrane, and the hollow flat membrane formed by the flat membrane combined with the first support member 121 not only has the advantages of high flux, high selectivity, and easy cleaning, but also has a certain mechanical strength and rigidity, an adjustable pore size, and better anti-pollution performance.

[0049] In some embodiments, the type of the filter membrane 111 is adapted to the structure of the filter structure 100. In some embodiments, the filter structure 100 may be a plate-like structure. When the filter structure 100 is a plate-like structure, the filter membrane 111 may be a hollow fiber membrane or a flat membrane to adapt to the shape of the filter structure 100 of the plate-like structure. In some embodiments, the filter structure 100 may be a columnar structure or a columnar-like structure. For example, the filter structure 100 may be a cylindrical structure or a cylindrical-like structure. When the filter structure 100 is a cylindrical structure or a cylindrical-like structure, the filter membrane 111 may be a rolled membrane to adapt to the shape of the filter structure 100. In some embodiments, the rolled membrane may be formed by curling the flat membrane in other embodiments of the present specification. Figure 14-16 The related embodiments provide a filtration structure 300 of a cylindrical structure, wherein the filtration membrane is a roll membrane. For more details about the filtration structure 300, see Figure 14-16 And its embodiments are not described in detail here.

[0050] In some embodiments, Figure 3 As shown, in order to improve the structural rigidity of the filter membrane 111 and prevent the filter membrane 111 from deforming, the filter layer 110 may further include a mesh 112 , and the mesh 112 may support the filter membrane 111 .

[0051] In some embodiments, the number of screens 112 may be one or more. Figure 3 In the embodiment, the filter layer 110-2 includes a screen 112. In some embodiments, when a circulation layer 120 is provided along the filtering direction of the filter layer 110, the screen 112 can be provided on the side of the filter membrane 111 away from the circulation layer 120, so that the two sides of the filtering direction of the filter membrane 111 are supported by the circulation layer 120 and the screen 112 respectively, further improving the structural rigidity of the filter membrane 111, reducing the degree of compression deformation, and ensuring that the diameter of the first flow channel can be well maintained. In some embodiments, when the circulation layer 120 is provided on both sides of the filtering direction of the filter layer 110, the screen 112 can be provided on the side of the filter membrane 111 close to one of the circulation layers 120.

[0052] In some embodiments, Fig. 9 and Fig.10As shown, the screen 112 can be connected to the housing 130. In some embodiments, the screen 112 can be fixedly connected or detachably connected to the housing 130. The specific methods of fixed connection and detachable connection can be described in other embodiments of this specification, and will not be repeated here. In some embodiments, the material for making the screen 112 can include nylon, polypropylene, etc.

[0053] In some embodiments, the mesh 112 can further screen the material passing through the filter membrane 111. Figure 3 , Fig. 9 and Fig.10 As shown, the screen 112 is provided with a plurality of screen holes 1121, and the aperture of the screen holes 1121 can be smaller than the aperture of the filter hole, and the screen holes 1121 can further intercept and separate the molecules or particles passing through the filter membrane 111. The principle of interception and separation of the screen 112 is the same or similar to that of the filter membrane 111, and will not be repeated here. In some embodiments, the aperture of the screen hole 1121 can be in the range of 10 microns to 200 microns. In some embodiments, the aperture of the screen hole 1121 can be in the range of 200 microns to 2 millimeters. In some embodiments, the aperture of the screen hole 1121 can be in the range of 2 millimeters to 10 millimeters.

[0054] In some embodiments, since the filter membrane 111 needs to be prevented from deforming, a rigid support needs to be provided to the filter membrane 111. Rigid support refers to a structural support that provides high strength, rigidity and stability through certain materials or components. The rigid support can withstand a large weight and pressure, so that the entire filter membrane 111 remains stable and is not easily deformed. In some embodiments, the material for making the first support member 121 may include polyoxymethylene (POM), polypropylene, polycarbonate (PC), etc.

[0055] In some embodiments, Figure 1-Figure 3 As shown, the first support member 121 may include a plurality of first sub-support members 1211 arranged at intervals, each of the first sub-support members 1211 extending along the length direction of the first flow channel 122, and a first flow channel 122 is arranged between two adjacent first sub-support members 1211 in a first support member 121. The extending direction of the first flow channel 122 can be represented by the X-axis. Figure 1 In the illustrated embodiment, the first support member 121 may include a plurality of first sub-support members 1211 (the two first sub-support members 1211 located at both ends of the distribution direction of the first flow channel 122 are not fully shown), the plurality of first sub-support members 1211 are parallel to each other and spaced apart along the Y-axis direction, the plurality of first sub-support members 1211 are all parallel to the surface of the filter layer 110, and a first flow channel 122 is provided between two adjacent first sub-support members 1211 in a first support member 121.

[0056] It should be noted that Figure 1 The number of the first sub-support members 1211 and the first flow channel 122 in the illustrated embodiment is for illustration purposes only and is not intended to limit the number of the first sub-support members 1211 and the first flow channel 122. The number of the first sub-support members 1211 and the first flow channel 122 can be increased or decreased according to actual needs. For example, if the liquid to be filtered is large, the number of the first sub-support members 1211 and the first flow channel 122 can be increased, and if the liquid to be filtered is small, the number of the first sub-support members 1211 and the first flow channel 122 can be reduced.

[0057] In some embodiments, Figure 5 As shown, the two ends of the length direction of the plurality of first sub-support members 1211 can be connected to the housing 130 respectively. In some embodiments, the two ends of the length direction of the first sub-support member 1211 can be detachably connected to the housing 130. Exemplary detachable connection methods may include snap connection, magnetic connection, etc. In some embodiments, the two ends of the first sub-support member 1211 in the extension direction can be fixedly connected to the housing 130 to ensure the stability of the entire filter structure 100. Exemplary fixed connection methods may include gluing, hot melt fixing, etc.

[0058] In some embodiments, Figure 4As shown, the first support member 121 may be a wave plate-like structure, and two adjacent first flow channels 122 may be located on different sides of the thickness direction of the first support member 121. The thickness direction of the first support member 121 may be parallel to the filtering direction of the filter layer 110. As an example only, both ends of the first support member 121 in the length direction may be connected to the side wall of the housing 130, and a plurality of first flow channels 122 are provided on both sides of the thickness direction of the first support member 121, and the extension direction of the first flow channel 122 is perpendicular to the thickness direction of the first support member 121. For the convenience of description, the first flow channel 122 provided on the upper side of the thickness direction of the first support member 121 may be referred to as a first sub-flow channel 1221, and the first flow channel 122 provided on the lower side of the thickness direction of the first support member 121 may be referred to as a second sub-flow channel 1222. The plurality of first sub-flow channels 1221 are located in the same plane and the extension directions are parallel to each other, and the plurality of second sub-flow channels 1222 are located in another plane and the extension directions are parallel to each other. In this embodiment, the first sub-channel 1221 and the second sub-channel 1222 can both be used for the flow of the liquid to be filtered, and are used for filtering in different directions. For example, after the liquid to be filtered is injected into the first sub-channel 1221 and the second sub-channel 1222 respectively, the liquid to be filtered in the first sub-channel 1221 can contact the filter membrane 111 above, thereby filtering. The liquid to be filtered in the second sub-channel 1222 can contact the filter membrane 111 below, thereby filtering. In some cases, since the first sub-channel 1221 and the second sub-channel 1222 are respectively located on both sides of the thickness direction of the first support member 121 and are separated by the first support member 121, the first sub-channel 1221 and the second sub-channel 1222 can be injected with the liquid to be filtered at the same time for filtering without affecting each other. In other cases, the strength and rigidity of the corrugated plate structure are higher, the support for the filter layer 110 is stronger, and the filter layer 110 is less likely to be deformed by pressure, further improving the filtering effect and speed.

[0059] In some embodiments, the connection surface between the first support member 121 and the surface of the filter layer 110 is a curved surface. Figure 1 In the embodiment shown, the connection surface between the first sub-support member 1211 and the surface of the filter layer 110 is a curved surface. Figure 4In the illustrated embodiment, the connection surfaces between the first sub-channel 1221 and the second sub-channel 1222 and the surface of the filter layer 110 are arcuate surfaces. Since the connection surface between the first support member 121 and the surface of the filter layer 110 is an arcuate surface, the connection surface between the first support member 121 and the surface of the filter layer 110 is smoother, which can effectively reduce the shear force. The friction resistance of substances such as molecules (for example, cells) or particles in the liquid to be filtered can be reduced when passing through the connection surface between the first support member 121 and the filter membrane 111, which can not only effectively increase the flow rate of substances such as molecules (for example, cells) or particles, but also avoid the accumulation of substances such as molecules (for example, cells) or particles in the liquid to be filtered in the first channel 122, reduce the possibility of blockage of the first channel 122, and thus improve the filtration efficiency and filtration effect. In some embodiments, the side wall of the cross section of the first channel 122 may be arc-shaped. The cross section in this embodiment may refer to the cross section of the first channel 122 in the length direction. As an example only, with Figure 1 Taking the first support member 121 in the example, the two sides of the first flow channel 122 (i.e., the sides in the width direction of the first sub-support member 1211) can be arc-shaped. In other embodiments, the sidewalls of the cross section of the first flow channel 122 can be in other shapes, such as wavy or straight. It is understandable that when the first support member 121 is Figure 4 In the case of the corrugated plate structure shown, the two side edges of the first sub-channel 1221 and the second sub-channel 1222 can also be set as arcs, and the connecting surface between the first support member 121 and the surface of the filter layer 110 can be set as an arc surface, so as to effectively reduce the shear force.

[0060] In some embodiments, the filter structure 100 may further include at least one permeable layer 140 disposed along the filtering direction of the filter layer 110. Figure 1 In the embodiment, a permeable layer 140 is provided on the side of the filter layer 110 away from the circulation layer 120. After the liquid to be filtered is injected into the first flow channel 122, the liquid to be filtered will start to be filtered along the contact surface between each first flow channel 122 and the adjacent filter membrane 111. After the liquid to be filtered passes through the filter membrane 111, it will start to be filtered along the contact surface between the surface of the filter membrane 111 and the adjacent permeable layer 140. In addition, the first support member 121 of the circulation layer 120 and the second support member 141 of the permeable layer 140 can simultaneously support the filter membrane 111 of the filter layer 110, thereby further improving the rigidity of the filter membrane 111 structure, preventing the filter membrane 111 from being deformed by the pressure from the liquid to be filtered, and improving the filtering effect and filtering speed.

[0061] In some embodiments, the transmission layer 140 may be provided with at least one second support member 141 and at least one second flow channel 142 , and the second flow channel 142 is spaced apart from the second support member 141 .

[0062] In some embodiments, the number of the second flow channels 142 is multiple, and the multiple second flow channels 142 can be arranged at intervals, and two adjacent second flow channels 142 can be separated by a second support member 141. The multiple second flow channels 142 are arranged at intervals, which means that the multiple second flow channels 142 are parallel to each other, and the plane where the multiple second flow channels 142 are located is parallel to the surface of the filter layer 110. In some cases, since the second support member 141 is arranged at intervals between two adjacent second flow channels 142, each second flow channel 142 is relatively independent, and the liquid to be filtered in each second flow channel 142 will not affect each other, so that the liquid to be filtered in each second flow channel 142 is more uniform, which is more conducive to the filtration of high-flux liquid.

[0063] In some embodiments, the second support member 141 may be provided with a second connecting hole (not shown in the figure). When the number of second flow channels 142 is multiple, the second connecting hole of the second support member 141 may connect two adjacent second flow channels 142 so that the liquid in the adjacent second flow channels 142 can convect and diffuse.

[0064] In some embodiments, the filter structure 100 may not need to be provided with a permeable layer 140. When the molecules or particles passing through the permeable layer 140 are not target biological substances (i.e., biological substances to be obtained), the permeable layer 140 may not be provided. Figure 1 For example, the target biological substance is the cells retained by the filter layer 110. After the liquid to be filtered passes through the circulation layer 120, the filter layer 110 and the permeable layer 140 in sequence, the liquid that passes through the filter layer 110 and enters the permeable layer 140 can be regarded as waste liquid. In this case, there is no need to set the permeable layer 140. Figure 11-13 The schematic diagram of another filtering structure is shown as an example. Figure 1-Figure 3 The difference of the filter structure 100 shown is that Figure 11-13The filter structure 200 in the illustrated embodiment is not provided with a permeable layer 140, and the circulation layer 120, the filter layer 110 and the housing 130 of the filter structure 200 may be the same or similar to the circulation layer 120, the filter layer 110 and the housing 130 of the filter structure 100. In some embodiments, when the molecules or particles that eventually pass through the permeable layer 140 are target biological substances, it can be determined whether to set the permeable layer 140 according to the sensitivity of the target biological substances to shear force. As an example only, since the extension direction of the second flow channel 142 is perpendicular to the filtering direction of the filter layer 110, thereby forming a tangential flow channel parallel to the filter layer 110, the molecules or particulate substances that pass through the filter layer 110 and enter the permeable layer 140 will be affected by a large shear force. If the molecules (for example, exosomes) or particulate substances are highly sensitive to shear force and are easily damaged by the shear force, the permeable layer 140 may not be provided. If the molecules or particulate substances are less sensitive to shear force and are not easily damaged by the shear force, the permeable layer 140 may be provided.

[0065] In some embodiments, when the second support member 141 and the second flow channel 142 (ie, the permeable layer 140 ) are provided, the second support member 141 can support the filter layer 110 , so the screen 112 does not need to be provided.

[0066] In some embodiments, the connection surface between the second support member 141 and the surface of the filter layer 110 is an arc surface to reduce the friction resistance of molecules (e.g., cells) or particles in the liquid to be filtered when passing through the connection surface between the second support member 141 and the filter membrane 111. In some embodiments, the sidewalls of the cross section of the second flow channel 142 may be arc-shaped. As an example only, the two side edges of the second flow channel 142 (i.e., the side edges in the width direction of the second support member 141) may be arc-shaped. In other embodiments, the sidewalls of the cross section of the second flow channel 142 may be in other shapes, such as wavy, straight (e.g., Figure 7 and Figure 8 shown).

[0067] In some embodiments, the number of permeable layers 140 and filter layers 110 can be multiple, and filter layers 110 are provided on both sides of the filtering direction of at least one permeable layer 140. In some embodiments, the filtering direction of the permeable layer 140 can be parallel to the filtering direction of the filter layer 110. Figure 3 In the illustrated embodiment, a filter layer 110 - 1 and a filter layer 110 - 2 are provided on both sides along the filtering direction of the permeable layer 140 - 1 .

[0068] In some embodiments, the filter structure may be a plate-like structure, for example, the filter structure may be a flat plate structure or an arc-shaped plate-like structure. Figure 1In the illustrated embodiment, the circulation layer 120, the filter layer 110 and the transmission layer 140 are all in the form of flat plates, so the filter structure 100 composed of the circulation layer 120, the filter layer 110 and the transmission layer 140 is a plate-like structure. In another example, the circulation layer, the filter layer and the transmission layer may all be in the form of curved plates, so the filter structure composed of the circulation layer, the filter layer and the transmission layer is an arc-shaped plate-like structure. In some embodiments, the filter structure may be a columnar structure or a columnar-like structure, for example, the filter structure may be an elliptical columnar structure, a cylindrical structure, a prismatic structure, a quasi-elliptical columnar structure, a quasi-cylindrical structure, a quasi-prismatic structure, etc.

[0069] Fig.14 is a schematic cross-sectional view of a filtering structure according to other embodiments of the present specification; Fig.15 yes Fig.14 A schematic diagram of the flow direction of the liquid to be filtered in the circulation layer of the filtration structure; Fig.16 yes Fig.14 Schematic diagram of the flow direction of the leachate in the filter layer of the filter structure; Figure 14-16 Another cross-sectional schematic diagram of a filter structure is shown as an example. In some embodiments, the filter structure 300 may include a filtrate discharge pipeline 360. The filter layer 310 and the flow layer 320 are both arranged along the circumference of the filtrate discharge pipeline 360 ​​(e.g., Figure 14-16 The filtrate discharge pipeline 360 ​​is spirally wound (in the direction indicated by the arrow A in the middle), and the filter layer 310 and the circulation layer 320 are alternately arranged in the radial direction of the filtrate discharge pipeline 360. The filtrate discharge pipeline 360 ​​is provided with a collection hole 361 penetrating the side wall of the filtrate discharge pipeline 360, and the ends of the circulation layer 320 and the filter layer 310 away from the filtrate discharge pipeline 360 ​​along the spiral direction are both closed, and the end of the circulation layer 320 close to the filtrate discharge pipeline 360 ​​along the spiral direction is connected to the side wall of the filtrate discharge pipeline 360, and the end of the filter layer 310 close to the filtrate discharge pipeline 360 ​​along the spiral direction is connected to the inside of the filtrate discharge pipeline 360 ​​through the collection hole 361.

[0070] In this embodiment, the liquid to be filtered can enter the circulation layer 320 from the inlet end of the filter structure 300. Since the filter layer 310 and the circulation layer 320 are spirally wound along the circumference of the filtrate discharge pipeline 360, and the filter layer 310 and the circulation layer 320 are alternately arranged in the radial direction of the filtrate discharge pipeline 360, the filter layer 310 and the circulation layer 320 may be wound multiple times. In the radial direction of the filtrate discharge pipeline 360, the filter layer 310 and the circulation layer 320 may have multiple ring structures. The liquid to be filtered in each circulation ring structure can flow to the radially adjacent filter ring structure and be filtered by the filter ring structure (for example, the filter membrane 311-1 and the filter membrane 311-2 of the filter layer 310). For example, Fig.15In the direction of the arrow P in the embodiment (the direction indicated by the arrow P passes through the central axis of the filtered liquid discharge pipeline 360), the filter layer 310 has a first filter ring layer structure 313 and a second filter ring layer structure 314, and the circulation layer 320 has a first circulation ring layer structure 323 and a second circulation ring layer structure 324, wherein the first filter ring layer structure 313, the first circulation ring layer structure 323, the second filter ring layer structure 314 and the second circulation ring layer structure 324 are connected in sequence. After such arrangement, when the first circulation ring layer structure 323 and the first filter ring layer structure 313 are connected, the liquid to be filtered in the first circulation ring layer structure 323 can flow to the first filter ring layer structure 313 (such as Fig.15 When the first circulation ring structure 323 and / or the second circulation ring structure 324 are connected to the second filtration ring structure 314, the liquid to be filtered out of the first circulation ring structure 323 and / or the second circulation ring structure 324 can flow to the second filtration ring structure 314 (as shown by the arrow in the middle). Fig.15 The connection mentioned here means that the substances in the liquid to be filtered in the circulation layer structure can enter the filtering layer structure under certain conditions. In some embodiments, a barrier layer may be provided between the circulation layer structure and the filtering layer structure. For example, a barrier layer is provided between the first circulation layer structure 323 and the second filtering layer structure 314 to restrict the liquid to be filtered in the first circulation layer structure 323 from flowing to the second filtering layer structure 314. Among them, after the liquid to be filtered passes through the filtering structure 300, the liquid retained in the circulation layer 320 (i.e., each circulation layer structure) is the retained liquid, and the liquid entering each filtering layer structure after being filtered through the filter membrane (i.e., the liquid flowing into the filtering layer) is the permeate. Since one end of the filter layer 310 is connected to the inside of the filtrate discharge pipeline 360 ​​and the other end is closed, and the filter layer 310 is distributed in a spiral shape, the leachate flowing into the filter layer 310 can flow to the center of the filter structure 300 (for example, the two ends of the filter layer 310 in the direction of the central axis of the filter structure 300 can be closed so that the leachate in the filter layer 310 can flow to the filtrate discharge pipeline 360), and enter the filtrate discharge pipeline 360 ​​from the collection hole 361 of the filtrate discharge pipeline 360 ​​(the leachate flows along the filter layer 310). Fig.16The filtrate in the circulation layer 320 can be discharged from the filtration structure 300 through the outlet of the filtrate discharge pipeline 360, and the retentate in the circulation layer 320 can be discharged from the filtration structure 300 through the outlet of the circulation layer 320 (i.e., the retentate end, for example, the end face of one end of the circulation layer 320), so that the retentate and the permeate can be discharged from the filtration structure 300 through different channels. In some embodiments, in any radial direction of the filtrate discharge pipeline 360, the circulation ring layer structure is connected to the adjacent filtration ring layer structure.

[0071] In some embodiments, there may be multiple collecting holes 361 , and the multiple collecting holes 361 may be arranged at intervals along the circumference of the filtrate discharge pipeline 360 ​​, so as to improve the efficiency of the leachate in the filter layer 310 entering the filtrate discharge pipeline 360 ​​.

[0072] In some embodiments, a filter layer 310 is disposed on one side of the flow layer 320 in the thickness direction. Figure 14-16 The embodiment shown can be regarded as a filter layer 310 disposed on one side of the circulation layer 320 in the thickness direction. When the filter layer 310 and the circulation layer 320 are spirally wound and alternately arranged along the radial direction of the filtrate discharge pipeline 360, the circulation layer structure may be connected to different filter layer structures. Fig.15 In the direction of the middle arrow P, the first circulation layer structure 323 is connected to the first filter layer structure 313 and the second filter layer structure 314 respectively, so the liquid to be filtered in the first circulation layer structure 323 can be filtered through the first filter layer structure 313 and the second filter layer structure 314. In some embodiments, filter layers 310 are provided on both sides of the circulation layer 320 in the thickness direction, which will not be described in detail here.

[0073] In some embodiments, the filter layer 310 may include one or more filter membranes. Figure 14-16In the illustrated embodiment, the filter layer 310 includes a filter membrane 311-1 and a filter membrane 311-2, and the filter membrane 311-1 and the filter membrane 311-2 are spirally wound along the circumference of the filtrate discharge pipeline 360, and a channel for the flow of the percolate is formed between the filter membrane 311-1 and the filter membrane 311-2. For example, in the direction of the arrow P, the second filter ring layer structure 314 includes a filter membrane 311-1 and a filter membrane 311-2, the filter membrane 311-2 located inside the second filter ring layer structure 314 is connected to the first circulation ring layer structure 323, and the liquid to be filtered in the first circulation ring layer structure 323 can be filtered by the filter membrane 311-2, and the filter membrane 311-1 located outside the second filter ring layer structure 314 is connected to the second circulation ring layer structure 324, and the liquid to be filtered in the second circulation ring layer structure 324 can be filtered by the filter membrane 311-1, so that the liquid to be filtered in the circulation layer 320 can be bidirectionally filtered. In another example, when the circulation layer 320 and the filter layer 310 both form a ring structure, the filter layer 310 may include a filter membrane (such as the filter membrane 311 - 1 ) connected to the circulation layer 320 to filter the liquid to be filtered in the circulation layer 320 .

[0074] In some embodiments, the filter layer 310 may include a mesh 312 that may support the filter membrane to form a channel for the percolate to flow. Figure 14-16 In the illustrated embodiment, a screen 312 is provided between the filter membrane 311-1 and the filter membrane 311-2 so as to form a channel for the permeate to flow between the filter membrane 311-1 and the filter membrane 311-2. Fig.15 In the direction of the middle arrow P, the filter membrane 311-1 is connected to the first circulation ring structure 323, the filter membrane 311-2 is connected to the second circulation ring structure 324, and a screen 312 is provided between the filter membrane 311-1 located inside the second filter ring structure 314 and the filter membrane 311-2 located outside the second filter ring structure 314, so that a channel for the circulation of the percolate is formed between the filter membrane 311-2 and the filter membrane 311-1. The inside refers to the side facing the center direction of the filter structure 300 along the direction of the arrow P, and the outside refers to the side away from the center direction of the filter structure 300 along the direction of the arrow P. The particulate matter, molecules or tissues in the liquid to be filtered of the second circulation ring structure 324 and the first circulation ring structure 323 whose size is smaller than the pore size of the filter hole can enter the channel through the filter holes of the filter membrane 311-1 and the filter membrane 311-2, and finally collect into the filtrate discharge pipeline 360 ​​through the collection hole 361 to discharge the filter structure 300.

[0075] In some embodiments, the filter layer 310 may further include a third support member (not shown), which may replace the screen 312 for supporting the filter membrane. In some embodiments, the third support member may be the same or similar to the first support member or the second support member in other embodiments of the specification. In some embodiments, the third support member may be used in combination with the screen 312 to increase the support strength of the filter membrane.

[0076] In some embodiments, the circulation layer 320 may include a first support member 321 and a first flow channel 322. The first support member 321 and the first flow channel 322 may be connected to Figure 1-Figure 13 The first support member 121 and the first flow channel 122 in the embodiment thereof are the same or similar, and are not described in detail here.

[0077] In some embodiments, the filter structure 300 may further include a permeable layer (not shown). Fig.15 On the basis of the illustrated embodiment, a permeable layer can be added. On the one hand, the permeable layer can further improve the rigidity of the filter membrane structure, prevent the filter membrane from being deformed by the pressure from the liquid to be filtered, and provide filtering effect and filtering speed. On the other hand, the filtrate can be further filtered to meet different filtering requirements. For the convenience of description, based on the direction of arrow P, the permeable layer can be arranged between the second filter ring layer structure 314 and the first circulation ring layer structure 323. In some embodiments, the permeable layer can be provided with at least one second support member and at least one second flow channel. The second flow channel and the second support member are spaced apart, and the second flow channel and the second support member can be spaced apart. Figure 1-Figure 13 The second flow channel 142 in the embodiment is the same as or similar to the second support member 141 and will not be described in detail here.

[0078] In some embodiments, the filter structure 300 may further include a housing (not shown), and the filter layer 310 and the flow layer 320 are both disposed in the housing. Figure 14-16 In the illustrated embodiment, the housing can be disposed outside the entire filter structure 300 to cover the outermost ring structure of the circulation layer 320 to prevent leakage of the liquid to be filtered in the outermost ring structure. In some embodiments, the housing can seal the ends of the circulation layer 320 and the filter layer 310 away from the filtrate discharge pipeline 360 ​​to prevent leakage of the liquid in the circulation layer and the leachate in the filter layer 310.

[0079] It should be noted that Figure 14-16 The embodiment shown is for illustration purposes only and is not intended to limit the specific structure of the filter structure 300. After fully understanding the technical solution of the filter structure 300, the filter structure 300 can be used for reference. Figure 14-16The filter structure 300 in the embodiment of the present invention is transformed to obtain a modified embodiment of the filter structure 300. For example, in the radial direction of the filtrate discharge pipeline 360, the filter layer 310 and the circulation layer 320 may not be stacked. For another example, the filtrate discharge pipeline 360 ​​of the filter structure 300 may not be necessary, that is, the leachate in the filter layer 310 may not be collected in the filtrate discharge pipeline 360 ​​and then discharged from the filter structure 300, but may be directly discharged from the opening of the filter layer 310.

[0080] In other embodiments, Fig.17 As shown, the filter structure 300 may include a filtrate discharge pipeline 360, the extension direction of the filtrate discharge pipeline 360 ​​is parallel to the central axis direction of the filter structure 300, and the filtrate discharge pipeline 360 ​​is provided with a collection hole 361 penetrating the side wall of the filtrate discharge pipeline 360. A plurality of filter groups are arranged at intervals in the circumferential direction of the filtrate discharge pipeline 360, and the plurality of filter groups are spirally surrounded along the circumferential direction of the filtrate discharge pipeline 360, each filter group includes at least one filter layer 310 and at least one circulation layer 320 connected to at least one filter layer 310, and the circulation layer 320 and the filter layer 310 are both closed at one end away from the filtrate discharge pipeline 360 ​​in the spiral direction, and the end of the circulation layer 320 close to the filtrate discharge pipeline 360 ​​in the spiral direction is connected to the side wall of the filtrate discharge pipeline 360, and the end of the filter layer 310 close to the filtrate discharge pipeline 360 ​​in the spiral direction is connected to the inside of the filtrate discharge pipeline 360 ​​through the collection hole 361.

[0081] In this embodiment, since the plurality of filter groups are arranged at intervals in the circumferential direction of the filtrate discharge pipeline 360, each filter group works independently of each other. Fig.17 In the illustrated embodiment, four filter groups are spaced apart in the circumferential direction of the filtrate discharge pipeline 360, and each filter group includes a flow layer 320 and a filter layer 310. The liquid to be filtered in the flow layer 320 can flow into the filter layer 310 connected thereto, and then enter the filtrate discharge pipeline 360 ​​through the collection hole 361 via the filter layer 310.

[0082] In some embodiments, it is not necessary for the multiple filter groups to be spirally arranged. For example, the multiple filter groups can extend radially along the filtrate discharge pipeline 360, that is, the filter layer 310 and the flow layer 320 extend radially along the filtrate discharge pipeline 360.

[0083] In some alternative embodiments, such as Fig.18As shown, the filter layer 310 and the circulation layer 320 of the filter structure 300 are both enclosed into a hollow structure with an outlet (not shown in the figure), and the filter layer 310 and the circulation layer 320 are coaxially sleeved. In this embodiment, the liquid to be filtered can enter the circulation layer 320 from the inlet end of the filter structure 300, and the liquid to be filtered is filtered by the filter membrane (for example, filter membrane 311-1, filter membrane 311-2) of the filter layer 310, and the liquid (i.e., percolate) flowing into the filter layer 310 can be discharged from the filter structure 300 through the outlet of the filter layer 310 (not shown in the figure), and the liquid (i.e., retentate) retained in the circulation layer 320 by the filter membrane can be discharged from the filter structure 300 through the outlet (i.e., the retention end, not shown in the figure) of the circulation layer 320.

[0084] In some embodiments, the number of the filter layer 310 and the circulation layer 320 are both one. As an example only, the filter layer 310 can be located on the inner side of the circulation layer 320, that is, the filter layer 310 is located on the side of the circulation layer 320 close to the center of the filter structure 300, and the liquid to be filtered in the circulation layer 320 can flow to the inner filter layer 310 and be filtered through the inner filter layer 310. In another example, the filter layer 310 can be located on the outer side of the circulation layer 320, that is, the filter layer 310 is located on the side of the circulation layer 320 away from the center of the filter structure 300, and the liquid to be filtered in the circulation layer 320 can flow to the outer filter layer 310 and be filtered through the outer filter layer 310.

[0085] In some embodiments, there are multiple filter layers 310 and / or circulation layers 320. As an example, there may be one circulation layer 320 and two filter layers 310. A filter layer 310-2 is disposed inside the circulation layer 320 and a filter layer 310-1 is disposed outside the circulation layer 320. The filter layer 310-1 and the filter layer 310-2 are independent of each other. The liquid to be filtered in the circulation layer 320 may flow to the filter layer 310-2 disposed inside the circulation layer 320 and the filter layer 310-1 disposed outside the circulation layer 320, respectively. In another example, the number of circulation layers 320 may be two, and the number of filter layers 310 may be one, that is, a circulation layer 320-2 is provided inside the filter layer 310, and a circulation layer 320-1 is provided outside the filter layer 310, so that the circulation layer 320-2 and the liquid to be filtered in the circulation layer 320-2 can flow to the filter layer 310, and be filtered through the filter layer 310, and the liquid (i.e., leachate) entering the filter layer 310 can be discharged from the filter structure from the outlet of the filter layer 310. In another example, the number of circulation layers 320 and filter layers 310 are both two, for example, the circulation layer 320 includes the circulation layer 320-1 and the circulation layer 320-2, and the filter layer 310 includes the filter layer 310-1 and the filter layer 310-2, and the filter layer 310-2, the circulation layer 320-2, the filter layer 310-1 and the circulation layer 320-1 are sequentially coaxially arranged radially outward of the filter structure 300. Among them, the circulation layer 320-1 is only connected to the filter layer 310-1, so the liquid to be filtered in the circulation layer 320-1 can flow to the filter layer 310-1 and be filtered through the filter layer 310-1, and because the circulation layer 320-2 is connected to the filter layer 310-1 and the filter layer 310-2 at the same time, the liquid to be filtered in the circulation layer 320-2 can flow to the filter layer 310-1 and the filter layer 310-2 respectively, and be filtered through the filter layer 310-1 and the filter layer 310-2, and the percolate in the filter layer 310-1 and the filter layer 310-2 can be discharged from the filter structure through their respective outlets. In some embodiments, the number of the filter layer 310 and / or the circulation layer 320 can be three, four, five or more, which will not be repeated here.

[0086] In some embodiments, the specific shape of the filter structure 300 may be related to the specific shape of the hollow structure enclosed by the filter layer 310 and the circulation layer 320. For example, if the hollow structure enclosed by the filter layer 310 and the circulation layer 320 is cylindrical, the filter structure 300 may be cylindrical. For another example, if the hollow structure enclosed by the filter layer 310 and the circulation layer 320 is prism-shaped, the filter structure 300 may be prism-shaped. In some embodiments, the shape of the hollow structure enclosed by the filter layer 310 and the circulation layer 320 may include regular or irregular shapes such as cylinders, prisms, and elliptical cylinders.

[0087] In some embodiments, Fig.19 and Fig. 20 As shown, the filtering structure (e.g., Figure 1 The filtration structure 100 in the embodiment may further include a liquid distribution component 470. The liquid distribution component 470 may be located at the inlet end and / or the interception end of the filtration structure. When the liquid distribution component 470 is located at the inlet end of the filtration structure, it is used to distribute the liquid to be filtered entering the filtration structure, so as to ensure that the liquid to be filtered is evenly distributed to each first flow channel (for example, Figure 1 The first flow channel 122 in the filter layer is used to allow the liquid to be filtered to enter the filter layer (for example, Figure 1 In the filter layer 110), the filter membrane of the filter layer (for example, Figure 1 The filter membrane 111 in the filter structure is used for filtering. Thereby, the accumulation and concentration polarization of the substances retained by the filter membrane on the surface of the filter membrane are delayed, the clogging of the filter membrane caused by the tangential flow of the liquid to be filtered is avoided, and the liquid to be filtered can be fully in contact with the surface of the filter membrane, which increases the contact area between the liquid to be filtered and the surface of the filter membrane, greatly improves the efficiency of filtration, and significantly improves the filtration effect. It can also avoid that the shape of the flow channel of the liquid to be filtered is affected, thereby reducing the shear force on the liquid to be filtered and significantly reducing the damage to the active substances in the filtered liquid. When the liquid distribution component 470 is located at the interception end of the filter structure, it is used to collect the retained liquid discharged from the interception end of the filter structure. The use of the liquid distribution component placed at the interception end of the filter structure to collect the retained liquid discharged from the interception end of the filter structure can also reduce the damage to the active substances in the retained liquid.

[0088] In some embodiments, the liquid distribution component 470 may include a liquid main pipe 471, a plurality of liquid diverters 472, and a housing 473. The plurality of liquid diverters 472 are disposed in the housing 473 and are spaced apart along the height direction of the housing 473. The liquid main pipe 471 connects the internal and external pipelines of the housing 473. In the height direction of the housing 473, the cross-sectional area of ​​the liquid diverter 472 gradually decreases from the side away from the liquid main pipe 471 to the side close to the liquid main pipe 471.

[0089] The height direction of the housing 473 is Fig.19 and Fig. 20 The arrow in the figure indicates the cross section of the liquid diverter 472. The cross section of the liquid diverter 472 refers to the cross section of the liquid diverter 472 perpendicular to the height direction of the shell 473. The liquid main pipe 471 is connected to an external pipeline, and is used to transport the liquid to be filtered into the shell 473 or collect the retained liquid in the shell 473. For example, the liquid main pipe 471 can be connected to a liquid pump (not shown in the figure). For another example, the liquid main pipe 471 can be connected to a waste liquid tank.

[0090] In some embodiments, the liquid distribution component 470 may further include a first liquid guide member 474, which is disposed on one side of the plurality of liquid diverting members 472 close to the liquid main pipe 471. The first liquid guide member 474 may be used to guide the liquid to be filtered input from the liquid main pipe 471 into the housing 473 to the plurality of liquid diverting members 472.

[0091] In some embodiments, along the height direction of the housing 473, the cross-sectional area of ​​the first liquid guide member 474 gradually decreases from the side away from the liquid main pipe 471 to the side close to the liquid main pipe 471. In some embodiments, the first liquid guide member 474 may include a cone (e.g., a cone, a pyramid), a terrace, a frustum, etc. For example, in Fig.19 In the illustrated embodiment, the first liquid guide member 474 is a cone, and the projection of the first liquid guide member 474 on the interception end and / or the inlet end surface of the filtration structure (such as the black area corresponding to the dotted line 476) is a circle. When the liquid to be filtered contacts the cone, the liquid to be filtered flows from the top to the bottom of the cone along the side wall of the cone, so that the liquid to be filtered is dispersed, and then a part of the liquid to be filtered can be drained to the liquid diverter 472.

[0092] In some embodiments, the liquid distribution component 470 may further include a second liquid guide member 475, which may be located on a side of the first liquid guide member 474 away from the liquid main pipe 471. The second liquid guide member 475 may be coaxially arranged with the first liquid guide member 474. In some cases, by arranging the second liquid guide member 475 below the first liquid guide member 474, it is possible to prevent the liquid to be filtered flowing between the first liquid guide member 474 and the first liquid diverter 4721 from falling directly below the first liquid guide member 474, causing uneven distribution of the liquid to be filtered. In some embodiments, along the height direction of the housing 473, the cross-sectional area of ​​the second liquid guide member 475 gradually decreases from the side away from the liquid main pipe 471 to the side close to the liquid main pipe 471. In some embodiments, the second liquid guide member 475 may be the same or similar to the first liquid guide member 474.

[0093] In some embodiments, the liquid diverter 472 may be a non-closed structure. As an example only, each liquid diverter 472 may include a plurality of diverter bars (not shown in the figure), and in the height direction of the shell 473, from the side away from the liquid main pipe 471 to the side close to the liquid main pipe 471, the cross-sectional area of ​​each diverter bar gradually decreases, and the plurality of diverter bars are arranged at intervals. In some embodiments, the cross-sectional shape of the diverter bar perpendicular to its own length direction is a triangle, a trapezoid, etc. In some embodiments, the length direction of the plurality of diverter bars may be perpendicular to the height direction of the shell 473, and the plurality of diverter bars may be arranged in parallel and at intervals along the height direction of the shell 473. In some embodiments, the plurality of diverter bars may be arranged in the same plane, and the plane where the plurality of diverter bars are located is perpendicular to the height direction of the shell 473. In some embodiments, the plurality of diverter bars may be arranged in the same plane, and the angle between the plane where the plurality of diverter bars are located and the height direction of the shell 473 is an acute angle. In some embodiments, the plurality of diverter bars may be arranged in different planes.

[0094] In some embodiments, the liquid diverter member 472 may be a liquid diverter ring, and a plurality of liquid diverter rings are coaxially arranged. In some embodiments, the axial direction of the liquid diverter ring is parallel to the height direction of the shell 473. In some embodiments, the angle between the axial direction of the liquid diverter ring and the height direction of the shell 473 is an acute angle, for example, the angle between the axial direction of the liquid diverter ring and the height direction of the shell 473 is 30 degrees. In some embodiments, the liquid diverter ring may be a regular or irregular annular structure such as a rectangular ring, a circular ring, or a triangular ring. For example, in Fig.19 and Fig. 20 In the embodiment shown, the liquid diverter 472 is a rectangular ring, and the projection of the liquid diverter 472 on the interception end and / or the inlet end of the filter structure (such as the black area corresponding to the dotted line 477 and the dotted line 478) is a rectangular ring. Fig.21 and Fig. 22 In the illustrated embodiment, the liquid diverter 572 is a circular ring, and the projection of the liquid diverter 572 on the end surface of the interception end and / or the inlet end of the filtration structure (such as the black area corresponding to the dotted line 577 and the dotted line 578) is a circular ring. In some embodiments, in the height direction of the housing 473, the inner cross-sectional area of ​​the plurality of liquid diverter rings decreases in sequence from the side away from the liquid main pipe 471 to the side close to the liquid main pipe 471. In some embodiments, the cross-sectional shape of the liquid diverter ring can be a triangle, a trapezoid, etc.

[0095] In some embodiments, the number of liquid diverters 472 can be increased or decreased to meet the needs of liquid distribution in different scenarios. For example, if the end surface area of ​​the inlet end and / or the interception end of the filter structure increases (or the number of first flow channels increases), the number of liquid diverters 472 can be increased. For another example, if the end surface area of ​​the inlet end and / or the interception end of the filter structure decreases (or the number of first flow channels decreases), the number of liquid diverters 472 can be reduced, such as reducing the number of liquid diverters 472 to one.

[0096] In some embodiments, a first drainage channel 479 is formed between the outer wall surface of the first liquid drainage member 474 and the inner wall surface of the liquid diversion member 472, between the outer wall surface and the inner wall surface of two adjacent liquid diversion members 472, and between the liquid diversion member 472 and the inner wall surface of the shell 473. The first opening of the first drainage channel 479 is connected to the liquid main pipe 471, and the second opening of the first drainage channel 479 corresponds to the end surface of the inlet end and / or the retention end of the filtering structure.

[0097] The first drainage channel 479 corresponds to the end surface of the inlet end and / or the retention end of the filtration structure, which means that when the liquid distribution component 470 is located at the inlet end and / or the retention end of the filtration structure, the projection of the first drainage channel 479 at least covers a portion of the end surface of the inlet end and / or the retention end of the filtration structure. The liquid to be filtered flowing out of the second opening of the first drainage channel 479 can flow to the corresponding area of ​​the end surface of the inlet end and / or the retention end, or the liquid flowing out of the end surface of the inlet end and / or the retention end can flow to the corresponding second opening of the first drainage channel 479. In some embodiments, the first drainage channel 479 formed between the outer wall surface of the first liquid drainage member 474 and the inner wall surface of the liquid diverter member 472 can be called a first sub-drainage channel 4791, the first drainage channel 479 formed between the outer wall surface and the inner wall surface of two adjacent liquid diverters 472 can be called a second sub-drainage channel 4792, and the first drainage channel 479 formed between the liquid diverter member 472 and the inner wall surface of the shell 473 can be called a third sub-drainage channel 4793. The first sub-drainage channel 4791, the second sub-drainage channel 4792 and the third sub-drainage channel 4793 respectively correspond to a portion of the end surface of the inlet end and / or the retention end of the filtration structure. It should be noted that Figure 19-20 as well as Figure 21-22 The embodiment shown is for illustration purposes only and is not intended to limit the number of the first drainage channel. In actual application, the number of sub-drainage channels may be increased or decreased according to the width of the filter structure. For example, when the end surface area of ​​the inlet end and / or the interception end of the filter structure increases, a fourth sub-drainage channel, a fifth sub-drainage channel, etc. may be added, and the end of the sub-drainage channel closest to the filter structure corresponds to a portion of the end surface area of ​​the inlet end and / or the interception end of the filter structure.

[0098] Fig.19 The schematic diagram of the liquid distribution component 470 including two liquid diverters 472 is shown as an example. For the convenience of description, the liquid diverter 472 close to the liquid main pipe 471 can be called the first liquid diverter 4721, and the other liquid diverter 472 can be called the second liquid diverter 4722. Fig.19 As shown, the first liquid diverter 4721 and the second liquid diverter 4722 are both rectangular rings, and the first liquid guide 474 is a cone. The farther away from the liquid main pipe 471, the larger the cross-sectional area of ​​the cone, and the thicker the wall thickness of each rectangular ring. Taking the liquid distribution component 470 disposed at the inlet end of the filter structure as an example, when the liquid to be filtered flows from the liquid main pipe 471 into the housing 473, a part of the liquid to be filtered will flow to the first liquid guide 474 and contact the first liquid guide 474, and the liquid to be filtered will be diverted by the first liquid guide 474, and a part of the liquid to be filtered diverted by the first liquid guide 474 will flow from the outside of the first liquid guide 474 (i.e., the first sub-drainage channel 4791 formed between the first liquid guide 474 and the first liquid diverter 4721) to the end face of the inlet end of the filter structure, and the other part will be drained to the first liquid diverter 4721. The liquid to be filtered flowing to the first liquid diverter 4721 will be diverted by the first liquid diverter 4721. A portion of the liquid to be filtered diverted by the first liquid diverter 4721 will flow from the inner side of the first liquid diverter 4721 (i.e., the first sub-drainage channel 4791) to the filtering structure, while another portion of the liquid to be filtered will flow from the outer side of the first liquid diverter 4721 (i.e., the second sub-drainage channel 4792 formed between the second liquid diverter 4722 and the first liquid diverter 4721) to the filtering structure. A portion of this portion of the liquid to be filtered (i.e., the liquid to be filtered flowing from the outer side of the first liquid diverter 4721) will flow to the second liquid diverter 4722 and contact the second liquid diverter 4722. Therefore, this part of the liquid to be filtered (i.e., the liquid to be filtered flowing toward the second liquid diverter 4722) will be diverted by the second liquid diverter 4722, and flow toward the inlet end of the filtering structure from the inner side (i.e., the second sub-drainage channel 4792) and the outer side (i.e., the third sub-drainage channel 4793 formed between the second liquid diverter 4722 and the shell 473) of the second liquid diverter 4722 respectively.

[0099] In some embodiments, in the height direction of the housing 473, the inner cross-sectional area of ​​the housing 473 gradually decreases from the side away from the liquid main pipe 471 to the side close to the liquid main pipe 471. In some embodiments, the projection of the housing 473 at the interception end and / or the inlet end of the filtration structure may correspond to the end surface shape of the interception end and / or the inlet end of the filtration structure. Fig.19 and Fig. 20In the illustrated embodiment, the end surface of the interception end and / or the inlet end of the filter structure is rectangular, so the projection of the housing 473 on the interception end and / or the inlet end of the filter structure is also rectangular. Figure 19-20 The liquid distribution component 470 shown can be suitable for a filter structure whose interception end and / or inlet end face is rectangular, such as Figure 1-Figure 3 The filtering structure 100 and Figure 11-13 The filter structures 200 in the embodiment are all plate-shaped structures, so the interception end and / or the inlet end face are rectangular. Fig.21 and Fig. 22 In the illustrated embodiment, the end surface of the interception end and / or the inlet end of the filter structure is circular, so the projection of the housing 573 on the interception end and / or the inlet end of the filter structure is also circular. Figure 21-22 The liquid distribution component 570 shown can be suitable for a filter structure whose interception end and / or inlet end face is circular or quasi-circular, such as Figure 14-18 The filtering structure 300 is a cylindrical structure, so the end surface of the interception end and / or the inlet end is circular.

[0100] In some embodiments, in addition to the shapes of the housing and the liquid diverter, Figure 21-22 The liquid distribution component 570 in the illustrated embodiment is Figure 19-20 The liquid distribution components 470 in the illustrated embodiments are the same or similar and will not be described in detail herein.

[0101] In some embodiments, the liquid guide member 474 and the plurality of liquid diverter members 472 may be connected to the housing 473. Fig.19 As shown, a fixing bracket 4701 is provided on the housing (not shown) of the filtering structure, and the fixing bracket 4701 can be used to fix the housing relative to the liquid distribution component 470. In some embodiments, the liquid guide member 474 and the plurality of liquid diverter members 472 can be detachably connected or fixedly connected to the housing 473, and the manner of detachable connection or fixed connection can refer to the description of other embodiments of this specification.

[0102] Fig. 20 It is a schematic diagram of the structure when the liquid distribution component is placed at a second angle according to some embodiments of the present specification. Fig. 20 The orientation of the liquid distribution component 470 shown can be similar to Fig.19The placement direction of the liquid distribution component 470 shown is opposite. In some embodiments, when it is necessary to distribute the liquid to be filtered to the filtering structure, the liquid distribution component 470 can be placed at a first angle or a second angle. For example, the liquid distribution component 470 is placed at the second angle, and the filtering structure can be located above the liquid distribution component 470, and the inlet end face of the filtering structure corresponds to the opening of the housing 473. The liquid main pipe 471 of the liquid distribution component 470 is connected to the liquid pump, and the liquid to be filtered is pumped into the housing 473 by the liquid pump, and then the liquid is transported to the inlet end of the filtering structure through the liquid distribution component 470.

[0103] In some embodiments, Fig.21 As shown, the liquid distribution component 670 may include a liquid main pipe (not shown) and at least one liquid branch pipe, the liquid branch pipe including a first opening and a plurality of second openings. One end of the liquid main pipe is connected to the first opening of the liquid branch pipe, the other end of the liquid main pipe is connected to the external pipeline, and the second opening of the liquid branch pipe corresponds to the end surface of the inlet end and / or the retention end of the filtration structure. In some embodiments, as Fig.23 As shown, the liquid branch pipe may include a first liquid branch pipe 671 and a second liquid branch pipe 672, each of which includes a first opening and a plurality of second openings; the first opening of the first liquid branch pipe 671 is connected to one end of the liquid main pipe, the first opening of the second liquid branch pipe 672 corresponds to the second opening of the first liquid branch pipe 671, and each second opening of the second liquid branch pipe 672 corresponds to the end surface of the inlet end and / or the interception end of the filtering structure. It should be noted that Fig.23 The embodiment shown is for illustration purposes only and does not limit the number of liquid branches. In actual applications, the number of liquid branches can be increased or decreased according to the width of the filter structure. For example, when the end surface of the inlet end and / or the interception end of the filter structure increases, a third liquid branch, a fourth liquid branch, a fifth liquid branch, etc. can be added. The communication mode between the liquid branches at each level is similar to the first liquid branch and the second liquid branch. The second opening of the liquid branch closest to the filter structure corresponds to the end surface of the inlet end and / or the interception end of the filter structure.

[0104] The first opening of the second liquid branch 672 corresponds to one of the second openings of the first liquid branch 671, which means that the number of the first openings of the second liquid branch 672 is the same as the number of the second openings of the first liquid branch 671, and one first opening of the second liquid branch 672 is connected to one of the second openings of the first liquid branch 671. Since the first liquid branch 671 and the second liquid branch 672 include multiple second openings, when the liquid to be filtered flows out from the first liquid branch 671 and / or the second liquid branch 672, it will be divided into multiple liquids. In some embodiments, the inner diameters of the second openings of the first liquid branch 671 are the same, and the inner diameters of the multiple second openings of the second liquid branch 672 are the same.

[0105] In this embodiment, when the liquid distribution component 670 is disposed at the inlet end of the filtering structure, after the liquid to be filtered flows into the first liquid branch pipe 671, it will flow into the second liquid branch pipes 672 from the multiple second openings. Then, the liquid to be filtered in each second liquid branch pipe 672 will flow out from the multiple second openings of the second liquid branch pipe 672 and enter the first flow channel, completing the distribution of the liquid to be filtered.

[0106] Just as an example, Fig.23 As shown, the number of the first liquid branch pipe 671 is one, the number of the second liquid branch pipe 672 is two, the first liquid branch pipe 671 and the second liquid branch pipe 672 each have two second openings, and the first openings of the two second liquid branches 672 are respectively connected to a second opening of the first liquid branch pipe 671. Each second opening of the two second liquid branches 672 corresponds to the end surface of the inlet end and / or the interception end of the filtering structure (not shown in the figure).

[0107] It should be noted that Fig.23 The structure of the liquid distribution component 670 shown is for illustration purposes only and is not intended to limit the number and shape of the liquid branches. In actual use, the number and shape of the liquid branches can be adjusted according to demand. In some embodiments, the number of liquid branches can be increased or decreased to meet the needs of liquid distribution. As an example only, when the end surface area of ​​the inlet end and / or the interception end of the filtering structure increases or the number of the first flow channel increases, the third liquid branch, the fourth liquid branch, the fifth liquid branch, etc. can be added, and the communication mode between the liquid branches at each level is similar to the first liquid branch and the second liquid branch, and the second opening of the liquid branch closest to the filtering structure corresponds to the end surface of the inlet end and / or the interception end of the filtering structure. In another example, when the end surface area of ​​the inlet end and / or the interception end of the filtering structure decreases and the number of the first flow channel decreases, the second liquid branch 672 can be omitted. In some embodiments, the first liquid branch 671 and the second liquid branch 672 can be round tubes, square tubes, etc.

[0108] In some embodiments, the connecting surfaces between the multiple second openings of the first liquid branch 671, the connecting surfaces between the multiple second openings of the second liquid branch 672, and the connecting surface between the first liquid branch 671 and the second liquid branch 672 can be arc-shaped surfaces to reduce the shear force and friction resistance to which the liquid to be filtered is subjected when passing through these positions, thereby avoiding damage to substances (e.g., cells) in the liquid to be filtered, for example, reducing damage to cells and improving cell activity.

[0109] In some embodiments, Fig.24 As shown, the liquid distribution component 770 may include a liquid main pipe (not shown in the figure), a port 773, at least one liquid diversion baffle 771, and at least one second drainage channel 772 defined by the liquid diversion baffle 771. The liquid diversion baffle 771 is spaced apart from the second drainage channel 772, the first opening of the second drainage channel 772 is communicated with the liquid main pipe, and the second opening of the second drainage channel 772 is communicated with the port 773. In this embodiment, the second opening of the second drainage channel 772 can be arranged corresponding to the end surface of the inlet end and / or the retention end of the filter structure 700 through the port 773 of the liquid distribution component 770, so that the liquid to be filtered can be transported to the inlet end of the filter structure 700, and / or the liquid discharged from the retention end (for example, the retention liquid) can enter the liquid distribution component 770.

[0110] In some embodiments, the number of the second drainage channel 772 may be one. For example, the number of the liquid diverter baffle 771 is one, and the surface of the liquid diverter baffle 771 facing away from the port 773 may define the second drainage channel 772. In some embodiments, the number of the second drainage channels 772 is multiple, and the lengths of the multiple second drainage channels 772 may be unequal. In some embodiments, the lengths of the multiple second drainage channels 772 increase sequentially from the direction close to the port 773 to the direction away from the port 773. In some embodiments, the direction from the direction close to the port 773 to the direction away from the port 773 of the liquid distribution component 770 may refer to Fig.24 In some embodiments, a plurality of liquid diversion baffles 771 and a second drainage channel 772 are arranged in parallel and spaced apart. Fig.24As shown, a plurality of liquid diverter baffles 771 can be arranged in parallel and spaced apart in the direction indicated by the arrow Q, and the surfaces of the adjacent liquid diverter baffles 771 and the liquid diverter baffles 771 away from the port 773 define the second drainage channel 772, so the plurality of second drainage channels 772 and the plurality of liquid diverter baffles 771 are arranged at intervals and parallel to each other. In some embodiments, the adjacent liquid diverter baffles 771 can be arranged at an angle. For example, the end of one of the two adjacent liquid diverter baffles 771 (i.e., the end of the liquid diverter baffle 771 away from the liquid main pipe) can be inclined toward the end of the other liquid diverter baffle 771. In some embodiments, along the direction from close to the port 773 to away from the port 773, the plurality of liquid diverter baffles 771 and the plurality of second drainage channels 772 are parallel to the end surface of the inlet end and / or the retention end of the filtration structure 700.

[0111] Fig.24 FIG. 7 is a schematic diagram showing an exemplary liquid distribution component 770 disposed at the inlet end of the filter structure 700. Fig.24 As shown, there are three liquid diverter baffles 771, and the three liquid diverter baffles 771 are parallel to each other. For the convenience of description, the liquid diverter baffle 771 farthest from the port 773 can be called the first liquid diverter baffle 7711, the liquid diverter baffle 771 closest to the port 773 can be called the third liquid diverter baffle 7713, and the liquid diverter baffle 771 between the third liquid diverter baffle 7713 and the first liquid diverter baffle 7711 can be called the second liquid diverter baffle 7712. A second drainage channel 772 (which may be referred to as a fourth sub-drainage channel 7721) is formed on the side of the first liquid diverter baffle 7711 away from the second liquid diverter baffle 7712, a second drainage channel 772 (which may be referred to as a fifth sub-drainage channel 7722) is formed between the first liquid diverter baffle 7711 and the second liquid diverter baffle 7712, and a second drainage channel 772 (which may be referred to as a sixth sub-drainage channel 7723) is formed between the third liquid diverter baffle 7713 and the second liquid diverter baffle 7712. In particular, along the direction from close to the port 773 to away from the port 773, the fourth sub-drainage channel 7721, the fifth sub-drainage channel 7722, the sixth sub-drainage channel 7723, the first liquid diverter baffle 7711, the second liquid diverter baffle 7712 and the third liquid diverter baffle 7713 are all parallel to the end face of the inlet end of the filter structure 700. Since the lengths of the fourth sub-drainage channel 7721, the fifth sub-drainage channel 7722 and the sixth sub-drainage channel 7723 decrease successively from the direction away from the port 773 to the direction close to the port 773, it can be ensured that the liquid to be filtered discharged from each second drainage channel 772 can be transported to the inlet end of the filtration structure 700, or that the liquid discharged from the retention end (i.e., the retained liquid) can flow into the second drainage channel 772.

[0112] In some embodiments, the number of liquid diverter baffles 771 can be increased or decreased to meet the needs of liquid distribution. As an example only, when the number of first flow channels increases, the number of liquid diverter baffles 771 can be increased. In another example, when the number of first flow channels decreases, the number of liquid diverter baffles 771 can be reduced. In some embodiments, the liquid diverter baffles 771 can be flat plates, corrugated plates, curved plates, etc.

[0113] This specification also provides a filtering structure based on the aforementioned embodiment (for example, Figure 1-Figure 3 The filtering structure 100, Figure 11-13 The filtering structure 200, Figure 14-18 The filtering method of the filtering structure 300 in the embodiment may include: inputting the liquid to be filtered through the inlet end of the filtering structure; collecting the retained liquid discharged from the retaining end of the filtering structure. The retaining end of the filtering structure in this embodiment may refer to the opening of the circulation layer. After the liquid to be filtered passes through the filtering structure, the retained liquid retained in the circulation layer may be discharged from the filtering structure through the opening of the circulation layer. In some embodiments, the liquid distribution component (for example, Fig.19 The liquid distribution component 470, Fig.21 The liquid distribution component 570, Fig.23 The liquid distribution part 670 or Fig.24 The liquid distribution component 770 in the filter structure is disposed at the inlet end of the filter structure, and the liquid to be filtered is transported to the inlet end of the filter structure through the liquid distribution component. In some embodiments, the liquid distribution component can be disposed at the retention end of the filter structure, and the retention liquid discharged from the retention end of the filter structure is collected by the liquid distribution component.

[0114] The beneficial effects of the filtration structure and the filtration method for the filtration structure provided in the present specification include but are not limited to: (1) Since at least one flow layer is arranged along the filtration direction of the filtration layer, the first support member can support the filtration membrane and establish one or more channels to guide the liquid to be filtered to flow through the surface of the filtration membrane. By utilizing the rigidity of the first support member, the first flow channel and the filtration membrane will not be significantly deformed during the entire filtration process, so that the diameter of the first flow channel can be well maintained, thereby making the resistance and disturbance to the liquid to be filtered smaller during the flow process, closer to the laminar flow state, greatly reducing the shear force on the filtered liquid, and significantly reducing the active substances in the filtered liquid. (2) Since a first support member is provided between two adjacent first flow channels in the same circulation layer, each first flow channel is relatively independent and can independently provide a flow for the liquid to be filtered. The liquid to be filtered in each first flow channel will not affect each other, so that the liquid to be filtered in each first flow channel is more uniform, which is more conducive to the tangential flow of the liquid to be filtered along the surface of the filter membrane, thereby delaying the accumulation and concentration polarization of the substances retained by the filter membrane on the surface of the filter membrane, avoiding premature clogging of the filter membrane, and improving the filtering effect; (3) Since a circulation layer is provided, after the liquid to be filtered enters the filtering structure, it will not all pass directly through the filter structure. Instead of passing through the filter membrane, the liquid to be filtered first enters the first flow channel. The resistance of the first flow channel is relatively small, so the resistance encountered by the liquid to be filtered when flowing in the filter structure is relatively small, which reduces the driving force required for the liquid to be filtered to enter the filter structure, thereby reducing the pressure of the liquid to be filtered on the filter membrane; (4) Since the extension direction of the first flow channel is parallel to the surface of the filter membrane, when the liquid to be filtered flows in the first flow channel, it is equivalent to flowing along the surface of the filter membrane, that is, tangential flow. The tangential flow can delay the accumulation and concentration polarization of the substances retained by the filter membrane on the surface of the filter membrane, thereby avoiding premature clogging of the filter membrane, and also enables the liquid to be filtered to fully contact with the surface of the filter membrane, thereby increasing the contact area between the liquid to be filtered and the surface of the filter membrane. The filtration efficiency is increased and the filtration effect is significantly improved; (5) by setting a liquid distribution component, the liquid distribution component is used to transport the liquid to be filtered to the inlet end of the filtration structure, which can ensure that the liquid to be filtered is injected into each first flow channel, so that the liquid to be filtered can be evenly distributed through the first flow channel into the filtration layer, and then filtered by the filtration membrane of the filtration layer. In addition, the flow channel design in the liquid distribution component significantly reduces the shear force on the liquid to be filtered, thereby reducing the damage to the active substance in the liquid to be filtered. The liquid distribution component placed at the retention end of the filtration structure is used to collect the retained liquid discharged from the retention end of the filtration structure, which can also reduce the damage to the active substance in the retained liquid.

[0115] The above description is only a preferred embodiment of this specification and is not intended to limit this specification. Any modifications, equivalent substitutions and improvements made within the spirit and principles of this specification should be included in the protection scope of this specification.

Claims

1. A filtering structure, characterized in that: comprising at least one filter layer and at least one flow layer arranged along the filter direction of the filter layer; The circulation layer includes at least one first support member and at least one first flow channel, wherein the first flow channel is used for the liquid to be filtered to flow through, and the first flow channel is spaced apart from the first support member.

2. The filtering structure according to claim 1, characterized in that: The interception end of the filtration structure is in communication with the circulation layer, and the intercepted liquid in the circulation layer is discharged through the interception end; and / or, the inlet end of the filtration structure is in communication with the flow layer; And / or, the filter layer comprises at least one or more filter membranes; preferably, the filter membrane comprises a hollow fiber membrane, a flat membrane or a rolled membrane; And / or, the filter structure further comprises a shell, the filter layer and the flow layer are both arranged in the shell, and the inlet end of the filter structure is arranged on the shell; And / or, there are multiple circulation layers, and both sides of each circulation layer in the thickness direction are provided with the filter layer; And / or, the number of the filter layers is multiple, and the flow layers are provided on both sides along the filtering direction of the filter layer; And / or, the filter layer comprises at least one or more filter membranes and a screen, and the screen is used to support the filter membrane; And / or, there are multiple first flow channels, the multiple first flow channels are arranged in parallel and spaced apart, and the planes where the multiple first flow channels are located are parallel to the surface of the filter layer; and / or, the extension direction of the first flow channel is parallel to the surface of the filter layer; And / or, the connection surface between the first support member and the surface of the filter layer is a curved surface; And / or, the first support member includes a plurality of first sub-support members arranged at intervals; each of the first sub-support members extends along the length direction of the first flow channel, and the first flow channel is arranged between two adjacent first sub-support members in the first support member; or, the first support member is a wave plate-shaped structure, and two adjacent first flow channels are respectively located on different sides of the thickness direction of the first support member; And / or, there are a plurality of first flow channels, the plurality of first flow channels are arranged at intervals, and two adjacent first flow channels are separated by the first support member; Preferably, the first supporting member is provided with a first communicating hole, and the first communicating hole communicates with two adjacent first flow channels; And / or, the filtration structure is a plate-like structure, and the filtration layer and the circulation layer are both plate-like; or, the filtration structure is a columnar structure or a columnar-like structure; When the filtering structure is a columnar structure or a columnar-like structure, The filter structure comprises a filtrate discharge pipeline, wherein the filter layer and the circulation layer are both spirally wound along the circumference of the filtrate discharge pipeline, and in the radial direction of the filtrate discharge pipeline, the filter layer and the circulation layer are alternately arranged; a collection hole penetrating the side wall of the filtrate discharge pipeline is provided on the filtrate discharge pipeline; the circulation layer and the filter layer are both closed at one end away from the filtrate discharge pipeline in the spiral direction, the circulation layer is connected to the side wall of the filtrate discharge pipeline at one end close to the filtrate discharge pipeline in the spiral direction, and the filter layer is connected to the inside of the filtrate discharge pipeline at one end close to the filtrate discharge pipeline through the collection hole; preferably, there are a plurality of collection holes, and the plurality of collection holes are arranged at intervals along the circumference of the filtrate discharge pipeline; Alternatively, when the filter structure is a columnar structure or a quasi-columnar structure, the filter layer and the circulation layer of the filter structure are both enclosed to form a hollow structure with an opening, and the filter layer and the circulation layer are coaxially sleeved.

3. The filtering structure according to claim 1, characterized in that: It also includes at least one transmission layer arranged along the filtering direction of the filtering layer; Preferably, the number of the permeable layer and the filter layer are both plural, and the filter layer is provided on both sides along the filtering direction of at least one of the permeable layers; Preferably, the permeable layer is provided with at least one second support member and at least one second flow channel, and the second flow channel is spaced apart from the second support member; More preferably, the connecting surface between the second support member and the surface of the filter layer is a curved surface; More preferably, the number of the second flow channels is multiple, the multiple second flow channels are arranged at intervals, and two adjacent second flow channels are separated by the second support member; Further preferably, the second supporting member is provided with a second communicating hole, and the second communicating hole communicates with two adjacent second flow channels.

4. The filtering structure according to claim 1, characterized in that: The filtering structure further comprises a liquid distribution component, wherein the liquid distribution component is located at the inlet end and / or the interception end of the filtering structure.

5. The filtering structure according to claim 4, characterized in that: The liquid distribution component comprises a liquid main pipe, a plurality of liquid diverter pieces and a shell; The plurality of liquid diverter members are arranged in the shell at intervals along the height direction of the shell, and along the height direction of the shell, the cross-sectional area of ​​the liquid diverter member gradually decreases from a side away from the liquid main pipe to a side close to the liquid main pipe; The liquid main pipe is used to connect the external pipeline with the interior of the shell; Preferably, the liquid distribution component further comprises a first liquid guiding member, and the first liquid guiding member is arranged on one side of the plurality of liquid diverting members close to the liquid main pipe; More preferably, along the height direction of the housing, from a side away from the liquid main pipe to a side close to the liquid main pipe, a cross-sectional area of ​​the first liquid guiding member gradually decreases; More preferably, a first drainage channel is formed between the outer wall surface of the first liquid drainage member and the inner wall surface of the liquid diverter member, between the outer wall surfaces and inner wall surfaces of two adjacent liquid diverters, and between the liquid diverter member and the inner wall surface of the shell, the first opening of the first drainage channel is communicated with the liquid main pipe, and the second opening of the first drainage channel corresponds to the end surface of the inlet end and / or the interception end of the filtering structure; More preferably, the liquid distribution component further comprises a second liquid guiding member, and the second liquid guiding member is located on a side of the first liquid guiding member away from the liquid main pipe; Further preferably, the second liquid guiding member is coaxially arranged with the first liquid guiding member; Further preferably, along the height direction of the housing, from a side away from the liquid main pipe to a side close to the liquid main pipe, a cross-sectional area of ​​the second liquid guiding member gradually decreases; Preferably, in the height direction of the shell, the inner cross-sectional area of ​​the shell gradually decreases from a side away from the liquid main pipe to a side close to the liquid main pipe.

6. The filtering structure according to claim 5, characterized in that: The liquid diverter is a non-closed structure; Preferably, the liquid flow dividing member comprises a plurality of flow dividing baffles, and in the height direction of the shell, from the side away from the liquid main pipe to the side close to the liquid main pipe, the cross-sectional area of ​​each flow dividing baffle gradually decreases, and the plurality of flow dividing baffles are arranged at intervals; more preferably, the length direction of the plurality of flow dividing baffles is perpendicular to the height direction of the shell, and the plurality of flow dividing baffles are arranged in parallel and at intervals along the height direction of the shell; More preferably, the plurality of diverter baffles are arranged on the same plane, and the plane where the plurality of diverter baffles are located is perpendicular to the height direction of the shell; or, The liquid diverter is a liquid diverter ring; Preferably, a plurality of the liquid diverter rings are coaxially arranged; Preferably, the axial direction of the liquid diverter ring is parallel to the height direction of the shell; or, the angle between the axial direction of the liquid diverter ring and the height direction of the shell is an acute angle; Preferably, the liquid diverter ring includes one or more of a rectangular ring, a circular ring and a triangular ring; Preferably, the cross-sectional shape of the liquid diverter ring includes a triangle and / or a trapezoid.

7. The filtering structure according to claim 4, characterized in that: The liquid distribution component includes a liquid main pipe and at least one liquid branch pipe; The liquid branch pipe includes a first opening and a plurality of second openings; One end of the liquid main pipe is connected to the first opening of the liquid branch pipe, the other end of the liquid main pipe is connected to the external pipeline, and the second opening of the liquid branch pipe corresponds to the end surface of the inlet end and / or the interception end of the filtering structure; Preferably, the at least one liquid branch pipe includes a first liquid branch pipe and a second liquid branch pipe, and the first liquid branch pipe and the second liquid branch pipe each include a first opening and a plurality of second openings; the first opening of the first liquid branch pipe is connected to one end of the liquid main pipe, and the first opening of the second liquid branch pipe is correspondingly connected to the second opening of the first liquid branch pipe, and each of the second openings of the second liquid branch pipe corresponds to an end surface of the inlet end and / or the retention end of the filtering structure.

8. The filtering structure according to claim 4, characterized in that: The liquid distribution component comprises a liquid main pipe, a port, at least one liquid diversion baffle and at least one second drainage channel defined by the liquid diversion baffle, wherein the liquid diversion baffle is spaced apart from the second drainage channel; The first opening of the second drainage channel is communicated with the liquid main pipe, the second opening of the second drainage channel is communicated with the port, and the port corresponds to the end surface of the inlet end and / or the retention end of the filtering structure; Preferably, there are multiple second drainage channels, and the lengths of the multiple second drainage channels are not equal; More preferably, along the direction from close to the port to far away from the port, the lengths of the plurality of second drainage channels increase sequentially; Preferably, along the direction from close to the port to far away from the port, a plurality of the liquid diversion baffles and a plurality of the second drainage channels are arranged in parallel and spaced apart; More preferably, along the direction from close to the port to away from the port, the plurality of liquid diversion baffles and the plurality of the second drainage channels are parallel to the end surface of the inlet end and / or the retention end of the filtering structure.

9. A filtering method for a filtering structure, characterized in that: include: Inputting the liquid to be filtered through the inlet end of the filtering structure; The retentate discharged from the retentate end of the filtration structure is collected.

10. The filtering method for a filtering structure according to claim 9, characterized in that: The step of inputting the liquid to be filtered through the inlet end of the filtering structure comprises: Disposing a liquid distribution component at the inlet end of the filtering structure; The liquid to be filtered is delivered to the inlet end of the filtering structure through the liquid distribution component; And / or, the collecting of the retentate discharged from the retentate end of the filtration structure comprises: Disposing the liquid distribution component at the interception end of the filter structure; The retentate discharged from the retentate end of the filtration structure is collected by the liquid distribution component.

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