A biaxial stirring mixer for a pharmaceutical-grade liquid drug

Abstract

The present invention discloses a biaxial stirring mixer for pharmaceutical-grade liquid drugs, which relates to the technical field of drug production. Through two swingable mixing and stirring shafts of the present invention, combined with ultrasonic generators embedded in the stirring blades, the mixing effect is enhanced at both the macroscopic and microscopic levels. The swing design of the stirring shafts enables the stirring blades to contact more liquid, improving the stirring uniformity. The cavitation effect of ultrasonic waves further promotes the refinement and dispersion of particles inside the liquid, ensuring the efficient mixing of drugs, and is particularly suitable for pharmaceutical-grade liquid drugs with high requirements for uniformity; the discharging process is controlled by an electric cylinder. After mixing is completed, the sealing plug is automatically withdrawn, enabling the mixed liquid to be quickly discharged through the funnel, avoiding the blockage of the pipeline by residues. This design not only improves the discharging efficiency but also ensures the cleanliness of the discharging pipeline, avoiding the problems of shutdown and difficult cleaning caused by pipeline blockage in traditional equipment, and is particularly suitable for pharmaceutical factories with high-efficiency production requirements.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical production, and particularly to a biaxial stirring mixer for pharmaceutical-grade liquid drugs. Background Art

[0002] Most of the common pharmaceutical-grade liquid drug stirring equipment on the market at present adopts a single-axis stirring structure. The fixed position and rotation speed of the stirring blades cannot be adjusted flexibly, which easily leads to uneven mixing of the pharmaceutical liquid. In addition, traditional stirring equipment generally lacks an efficient discharging system, and the liquid remains inside the equipment, resulting in incomplete discharging, increasing waste and cleaning difficulty in the production process. Especially in the cleaning process, traditional equipment usually requires manual disassembly and rinsing, with low efficiency and a high risk of cross-contamination. Therefore, the existing technology has significant deficiencies in terms of stirring uniformity, discharging efficiency, and equipment cleaning. Summary of the Invention

[0003] To overcome the defects of the above-mentioned prior art, the present invention provides the following technical solution: A biaxial stirring mixer for pharmaceutical-grade liquid drugs, including a base barrel. A mixing bottom sealing plate is fixed on the top of the base barrel. A plurality of discharging ports are opened at the circumference of the mixing bottom sealing plate. A mixing stirring chamber is fixedly arranged on the mixing bottom sealing plate. The mixing stirring chamber is used to accommodate the pharmaceutical liquid to be mixed. The discharging ports are used to discharge the mixed pharmaceutical liquid. A plugging sealing plug is hermetically inserted in each discharging port. All the plugging sealing plugs are fixed on a funnel. The funnel is used to drain all the discharged pharmaceutical liquid into a discharging pipe. Two mixing stirring shafts are rotatably installed inside the mixing stirring chamber. A plurality of stirring blades are fixed on each mixing stirring shaft. And each mixing stirring shaft can swing relative to each other to change the stirring position of the stirring blades inside the mixing stirring chamber. An ultrasonic generator is embedded in each stirring blade.

[0004] Preferably, the funnel and all the plugging sealing plugs are in sliding sealing fit with the inner wall of the base barrel. A discharging intermediate pipe is fixed at the bottom of the funnel. The discharging intermediate pipe is in sliding sealing fit with the discharging pipe.

[0005] Preferably, two concentrically arranged central dial plates and edge dial plates are rotatably fitted on the upper surface of the mixing bottom sealing plate. Two concentrically arranged driving rotating disks and intermediate driving gear disks are rotatably fitted on the lower surface of the mixing bottom sealing plate. Among them, the intermediate driving gear disk and the central dial plate are fixedly synchronously driven through a synchronous transmission shaft. The synchronous transmission shaft is in rotary sealing fit with the mixing bottom sealing plate. Among them, the edge dial plate and the driving rotating disk are in driving fit through a magnetic coupling method.

[0006] Preferably, two mixing and stirring shafts are arranged along the axial direction of the mixing and stirring chamber. Two symmetrically arranged driven mixing gears are rotatably installed on the lower surface of the mixing bottom sealing plate. The two driven mixing gears are in meshing transmission with the intermediate driving tooth disc. Two universal joints are rotatably installed on the upper surface of the mixing bottom sealing plate. A fixed transmission fit is established between the two universal joints and the two driven mixing gears through rotating shafts. A transmission fit is established between the two mixing and stirring shafts and the two driven mixing gears through the corresponding universal joints.

[0007] Preferably, a fixed transmission fit is established between the active rotating disk and the synchronous transmission shaft through the rotating disk bracket. A spline shaft is fixed at the bottom end of the synchronous transmission shaft. A cleaning brush hollow frame is sleeved on the spline shaft in a spline-sliding manner. A plurality of cleaning brushes that are slidably and rotatably matched with the inner wall of the funnel are fixed on the cleaning brush hollow frame. A rotating fit is established between the cleaning brush hollow frame and the middle discharge pipe. A plurality of through holes are opened on the cleaning brush hollow frame for discharging the liquid medicine. Axial displacement is not allowed between the cleaning brush hollow frame and the middle discharge pipe.

[0008] Preferably, two symmetrically arranged electric cylinders are fixedly installed on the inner wall of the base barrel through the electric cylinder brackets. The end parts of the telescopic rods of the two electric cylinders are fixedly matched with the funnel.

[0009] Preferably, a top adjusting support plate is fixed at the top end of the mixing and stirring chamber. An annular electromagnet is fixed at the circumference of the upper surface of the top adjusting support plate. A top sealing cover plate is fixed on the annular electromagnet. An adjusting support ring is fixed between the top sealing cover plate and the top adjusting support plate. Two symmetrically arranged adjusting support frames are slidably installed on the adjusting support ring through two corresponding parallel adjusting support sliding rods. An adjusting movable slider is rotatably matched at one end of each of the two adjusting support frames close to the mixing and stirring shaft. The adjusting movable slider is slidably sleeved on the corresponding mixing and stirring shaft.

[0010] Preferably, a reset spring is sleeved around each adjusting support sliding rod. The two ends of the reset spring are fixed to the adjusting support frame and the adjusting support ring. A permanent magnet block is fixed at the end of the adjusting support sliding rod away from the adjusting support frame. The permanent magnet block is in magnetic cooperation with the annular electromagnet.

[0011] Preferably, an overhead cover is fixed on the top sealing cover plate. A driving motor is fixed on the overhead cover. A plurality of feed ports are also opened on the overhead cover. A fixed transmission is established between the output shaft of the driving motor and the central dial through the main shaft.

[0012] The present invention has the following beneficial effects compared with the prior art: (1) Through two swingable mixing and stirring shafts and ultrasonic generators embedded in the stirring blades, the mixing effect is enhanced at both the macroscopic and microscopic levels. The swing design of the stirring shafts enables the stirring blades to contact more liquid, maximizing the stirring uniformity. The cavitation effect of ultrasonic waves further promotes the refinement and dispersion of particles inside the liquid, ensuring the efficient mixing of drugs, and is particularly suitable for pharmaceutical-grade liquid drugs with high requirements for uniformity; (2) Multiple discharge ports in the present invention are equipped with sealing plugs, and the discharging process is controlled by an electric cylinder. When the mixing is completed, the sealing plugs are automatically withdrawn, allowing the mixed liquid to be quickly discharged through the funnel, avoiding the blockage of the pipeline by residues. This design not only improves the discharging efficiency but also ensures the cleanliness of the discharging pipeline, avoiding the problems of shutdown and difficult cleaning caused by pipeline blockage in traditional equipment, and is particularly suitable for pharmaceutical factories with high-efficiency production requirements; (3) The cleaning brush hollow frame equipped in the present invention can automatically clean the inner wall of the funnel when the synchronous transmission shaft rotates, reducing the manual cleaning process after the equipment runs. This not only improves the cleaning efficiency but also reduces the risk of cross-contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is an overall external structure diagram of the present invention.

[0014] Figure 2 It is a schematic structural diagram of the electric cylinder part of the present invention.

[0015] Figure 3 For the present invention Figure 2 Schematic structural diagram of the part A therein.

[0016] Figure 4 It is a schematic structural diagram of the inside of the mixing and stirring chamber of the present invention.

[0017] Figure 5 It is a schematic structural diagram of the funnel part of the present invention.

[0018] Figure 6 It is a schematic structural diagram of the central dial part of the present invention.

[0019] In the figure: 101 - base barrel; 102 - discharge pipe; 103 - electric cylinder support; 104 - intermediate discharge pipe; 105 - electric cylinder; 106 - funnel; 107 - spline shaft; 108 - synchronous transmission shaft; 109 - cleaning brush; 110 - cleaning brush hollow frame; 111 - blockage sealing plug; 112 - discharge port; 113 - active rotating disk; 114 - rotating disk support; 115 - mixing bottom sealing plate; 116 - intermediate drive gear disk; 117 - driven mixing gear; 118 - mixing and stirring shaft; 119 - stirring paddle; 120 - universal joint; 121 - central dial; 122 - edge dial; 123 - mixing and stirring chamber; 124 - top adjusting support plate; 125 - adjusting support ring; 126 - adjusting support slide bar; 127 - adjusting support frame; 128 - adjusting movable slider; 129 - return spring; 130 - permanent magnet block; 131 - top sealing cover plate; 132 - annular electromagnet; 133 - overhead cover; 134 - drive motor; 135 - feed port; 136 - main shaft. Detailed implementation mode

[0020] The following combines the attached Figures 1-6 drawings, and further illustrates the technical solution of the present invention through specific implementation modes.

[0021] The present invention provides a biaxial stirring mixer for pharmaceutical-grade liquid drugs, including a base barrel 101. A mixing bottom sealing plate 115 is fixed at the top of the base barrel 101. A plurality of discharge ports 112 are provided at the circumference of the mixing bottom sealing plate 115. A mixing and stirring chamber 123 is fixedly arranged on the mixing bottom sealing plate 115. The mixing and stirring chamber 123 is used to accommodate the drug liquid to be mixed. The discharge ports 112 are used to discharge the mixed drug liquid. A blockage sealing plug 111 is hermetically inserted in each discharge port 112. All the blockage sealing plugs 111 are fixed on the funnel 106. The funnel 106 is used to drain all the discharged drug liquid into the discharge pipe 102. Two mixing and stirring shafts 118 are rotatably installed inside the mixing and stirring chamber 123. A plurality of stirring paddles 119 are fixed on each mixing and stirring shaft 118. And each mixing and stirring shaft 118 can swing relative to each other to change the stirring position of the stirring paddles 119 inside the mixing and stirring chamber 123. An ultrasonic generator is embedded in each stirring paddle 119. The funnel 106 and all the blockage sealing plugs 111 are in sliding and sealing fit with the inner wall of the base barrel 101. The bottom of the funnel 106 is fixed with an intermediate discharge pipe 104. The intermediate discharge pipe 104 is in sliding and sealing fit with the discharge pipe 102.

[0022] On the upper surface of the mixing bottom sealing plate 115, two concentrically arranged central dial wheels 121 and edge dial wheels 122 are rotatably fitted. On the lower surface of the mixing bottom sealing plate 115, two concentrically arranged driving rotating disks 113 and intermediate driving gear disks 116 are rotatably fitted. Among them, the intermediate driving gear disk 116 and the central dial wheel 121 are fixedly synchronously driven through a synchronous transmission shaft 108, and the synchronous transmission shaft 108 is rotatably and sealingly fitted with the mixing bottom sealing plate 115. Among them, the edge dial wheel 122 and the driving rotating disk 113 are drivingly fitted through magnetic coupling. Among them, two mixing stirring shafts 118 are arranged along the axial direction of the mixing stirring chamber 123. On the lower surface of the mixing bottom sealing plate 115, two symmetrically arranged driven mixing gears 117 are rotatably installed. The two driven mixing gears 117 are meshingly driven with the intermediate driving gear disk 116. On the upper surface of the mixing bottom sealing plate 115, two universal joints 120 are rotatably installed. The two universal joints 120 and the two driven mixing gears 117 are fixedly drivingly fitted through a rotating shaft. The two mixing stirring shafts 118 and the two driven mixing gears 117 are drivingly fitted through the corresponding universal joints 120. The driving rotating disk 113 and the synchronous transmission shaft 108 are fixedly drivingly fitted through a rotating disk bracket 114. A spline shaft 107 is fixed at the bottom end of the synchronous transmission shaft 108. A cleaning brush hollow frame 110 is sleeved on the spline shaft 107 in a spline sliding manner. A plurality of cleaning brushes 109 that are slidably and rotatably fitted with the inner wall of the funnel 106 are fixed on the cleaning brush hollow frame 110. Among them, the cleaning brush hollow frame 110 and the discharge intermediate pipe 104 are rotatably fitted. A plurality of through holes are formed in the cleaning brush hollow frame 110 for discharging the liquid medicine. The cleaning brush hollow frame 110 and the discharge intermediate pipe 104 cannot axially displace. On the inner wall of the base barrel 101, two symmetrically arranged electric cylinders 105 are fixedly installed through an electric cylinder bracket 103. The end parts of the telescopic rods of the two electric cylinders 105 are fixedly fitted with the funnel 106.

[0023] A top adjustment support plate 124 is fixed to the top of the mixing and stirring chamber 123, and an annular electromagnet 132 is fixed to the circumference of the upper surface of the top adjustment support plate 124. A top sealing cover plate 131 is fixed to the annular electromagnet 132, and an adjustment support ring 125 is fixed between the top sealing cover plate 131 and the top adjustment support plate 124. Two symmetrically arranged adjustment support frames 127 are slidably installed on the adjustment support ring 125 through two corresponding parallel adjustment support slide bars 126. The ends of the two adjustment support frames 127 close to the mixing and stirring shaft 118 are both rotatably matched with an adjustment movable slide block 128, and the adjustment movable slide block 128 is slidably sleeved on the corresponding mixing and stirring shaft 118. A return spring 129 is sleeved around each adjustment support slide bar 126, and the two ends of the return spring 129 are fixed to the adjustment support frame 127 and the adjustment support ring 125. A permanent magnet block 130 is fixed to the end of the adjustment support slide bar 126 away from the adjustment support frame 127, and the permanent magnet block 130 is magnetically matched with the annular electromagnet 132. An overhead cover 133 is fixedly mounted on the top sealing cover plate 131 , a driving motor 134 is fixedly mounted on the overhead cover 133 , a plurality of feed ports 135 are also provided on the overhead cover 133 , and a main shaft 136 is used for fixed transmission between the output shaft of the driving motor 134 and the center dial wheel 121 .

[0024] The working principle of a biaxial stirring mixer for a pharmaceutical-grade liquid drug disclosed by the present invention is as follows: The drugs to be mixed are poured into the mixing and stirring chamber 123 through the feed port 135, and then the driving motor 134 is started. The output shaft of the driving motor 134 drives the central dial 121 to rotate through the main shaft 136. The rotation of the central dial 121 drives the intermediate driving gear disk 116 and the rotating disk bracket 114 to rotate through the synchronous transmission shaft 108. Among them, the rotating disk bracket 114 drives the active rotating disk 113 to rotate, and the active rotating disk 113 drives the edge dial 122 to rotate through magnetic force. At this time, the rotation of the central dial 121 and the edge dial 122 drives the drug liquid inside the mixing and stirring chamber 123 to rotate. At the same time, the rotation of the intermediate driving gear disk 116 drives the two driven mixing gears 117 to rotate. The two driven mixing gears 117 drive the mixing and stirring shaft 118 to rotate through the universal joint 120. The mixing and stirring shaft 118 drives the stirring blades 119 to rotate. The rotation of the stirring blades 119 drives the surrounding drug liquid to rotate, and cooperates with the rotation of the drug liquid driven by the central dial 121 and the edge dial 122, so as to realize the stirring work of all drugs inside the mixing and stirring chamber 123. At the same time, in order to better make the stirring blades 119 contact more drug liquid, the mixing and stirring shaft 118 can be driven to swing, so that the stirring blades 119 swing, so that the stirring blades 119 contact more drug liquid. Specifically, only need to control the ring electromagnet 132 to generate magnetic force. The ring electromagnet 132 repels or attracts the permanent magnet block 130, so as to drive the permanent magnet block 130 to move away from or close to the ring electromagnet 132. The movement of the permanent magnet block 130 drives the adjustment support slide bar 126 to move. The movement of the adjustment support slide bar 126 drives the adjustment support frame 127 to move. The adjustment support frame 127 drives the adjustment movable slider 128 to slide on the mixing and stirring shaft 118. At this time, the top of the mixing and stirring shaft 118 will swing, so as to change the position of the stirring blades 119 inside the mixing and stirring chamber 123. Among them, the reset spring 129 can make the mixing and stirring shaft 118 return to the vertical position when the ring electromagnet 132 loses magnetic force. While the stirring blades 119 are stirring the drug liquid, start the ultrasonic generator inside the stirring blades 119 to enhance the mixing at the microscopic level through the ultrasonic cavitation effect.

[0025] After the mixing is completed, start the electric cylinder 105. The telescopic rod of the electric cylinder 105 drives the funnel 106 to slide downward along the inner wall of the base barrel 101, so that the blocking seal plug 111 is withdrawn from the discharge port 112. At this time, the discharge port 112 is in an open state, and the liquid inside the mixing and stirring chamber 123 will enter the funnel 106 through the discharge port 112, and then be discharged into the discharge pipe 102 through the discharge intermediate pipe 104. The mixed pharmaceutical liquid is discharged to a specified position through the discharge pipe 102 for collection and treatment. If the whole equipment needs to be cleaned, only need to replace the medicine with water (select a suitable cleaning liquid according to the actual situation). When the synchronous transmission shaft 108 rotates, it will drive the cleaning brush hollow frame 110 to rotate through the spline shaft 107. The cleaning brush hollow frame 110 will drive the cleaning brush 109 to rotate. When the cleaning brush 109 rotates, it will clean the residual liquid on the inner wall of the funnel 106.

Claims

1. A biaxial stirring mixer for pharmaceutical-grade liquid drugs, characterized in that: The invention comprises a base barrel (101), a mixing bottom sealing plate (115) is fixed on the top of the base barrel (101), a plurality of discharge ports (112) are provided at the circumference of the mixing bottom sealing plate (115), a mixing and stirring chamber (123) is fixedly provided on the mixing bottom sealing plate (115), the mixing and stirring chamber (123) is used to contain the pharmaceutical liquid to be mixed, the discharge ports (112) are used to discharge the mixed pharmaceutical liquid, wherein a blocking sealing plug (111) is sealed and inserted in each discharge port (112), all the blocking sealing plugs (111) are fixed on the funnel (106), and the funnel (106) is used to drain all the discharged pharmaceutical liquid into the discharge pipe (102); Two mixing and stirring shafts (118) are rotatably mounted inside the mixing and stirring chamber (123), and a plurality of stirring blades (119) are fixed to each mixing and stirring shaft (118). Each mixing and stirring shaft (118) is capable of swinging relative to each other to change the stirring position of the stirring blades (119) inside the mixing and stirring chamber (123), and an ultrasonic generator is embedded inside each stirring blade (119); Two mixing and stirring shafts (118) are arranged along the axial direction of the mixing and stirring chamber (123); two symmetrically arranged driven mixing gears (117) are rotatably mounted on the lower surface of the mixing bottom sealing plate (115); the two driven mixing gears (117) are meshed with the intermediate driving gear plate (116) for transmission; two universal joints (120) are rotatably mounted on the upper surface of the mixing bottom sealing plate (115); the two universal joints (120) and the two driven mixing gears (117) are fixedly coupled with each other through a rotating shaft for transmission; The mixing and stirring shafts (118) and the two driven mixing gears (117) are matched through corresponding universal joints (120); a return spring (129) is provided around each adjusting support slide bar (126); both ends of the return spring (129) are fixed to the adjusting support frame (127) and the adjusting support ring (125); a permanent magnet (130) is fixed to one end of the adjusting support slide bar (126) away from the adjusting support frame (127); the permanent magnet (130) and the annular electromagnet (132) are matched by magnetic force; The funnel (106) and all the plugging sealing plugs (111) are in sliding sealing fit with the inner wall of the base barrel (101). A discharge intermediate pipe (104) is fixed to the bottom of the funnel (106), and there is a sliding sealing fit between the discharge intermediate pipe (104) and the discharge pipe (102); on the upper surface of the mixing bottom sealing plate (115), two concentrically arranged central dial plates (121) and edge dial plates (122) are in rotational fit, and on the lower surface of the mixing bottom sealing plate (115), two concentrically arranged driving rotating disks (113) and an intermediate driving gear disk (116) are in rotational fit. Among them, the intermediate driving gear disk (116) and the central dial plate (121) are fixedly synchronously driven through a synchronous transmission shaft (108), and there is a rotational sealing fit between the synchronous transmission shaft (108) and the mixing bottom sealing plate (115). Among them, the edge dial plate (122) and the driving rotating disk (113) are in driving fit through magnetic coupling; the driving rotating disk (113) and the synchronous transmission shaft (108) are fixedly driven through a rotating disk bracket (114). The bottom end of the synchronous transmission shaft (108) is fixed with a spline shaft (107), and a cleaning brush hollow frame (110) is sleeved on the spline shaft (107) in a spline sliding manner. A plurality of cleaning brushes (109) that are in sliding and rotational fit with the inner wall of the funnel (106) are fixed on the cleaning brush hollow frame (110). Among them, the cleaning brush hollow frame (110) and the discharge intermediate pipe (104) are in rotational fit. A plurality of through holes are provided on the cleaning brush hollow frame (110) for discharging the liquid medicine, and there is no axial displacement between the cleaning brush hollow frame (110) and the discharge intermediate pipe (104).

2. The biaxial stirring mixer for a pharmaceutical-grade liquid drug according to claim 1, wherein: On the inner wall of the base barrel (101), two symmetrically arranged electric cylinders (105) are fixedly installed through electric cylinder brackets (103), and the end portions of the telescopic rods of the two electric cylinders (105) are fixedly fitted with the funnel (106).

3. The biaxial stirring mixer for a pharmaceutical-grade liquid drug according to claim 2, wherein: At the top of the mixing and stirring chamber (123), a top adjusting support plate (124) is fixed. At the circumference of the upper surface of the top adjusting support plate (124), an annular electromagnet (132) is fixed. A top sealing cover plate (131) is fixed on the annular electromagnet (132). An adjusting support ring (125) is fixed between the top sealing cover plate (131) and the top adjusting support plate (124). Two symmetrically arranged adjusting support frames (127) are slidably installed on the adjusting support ring (125) through two corresponding parallel adjusting support sliding rods (126). At one end of the two adjusting support frames (127) close to the mixing and stirring shaft (118), adjusting movable sliders (128) are in rotational fit, and the adjusting movable sliders (128) are slidably sleeved on the corresponding mixing and stirring shaft (118).

4. The biaxial stirring mixer for pharmaceutical-grade liquid medicine according to claim 3, wherein: A suspended cover (133) is fixed on the top sealing cover plate (131). A driving motor (134) is fixed on the suspended cover (133). A plurality of feed ports (135) are also provided on the suspended cover (133). The output shaft of the driving motor (134) and the central dial plate (121) are fixedly driven through a main shaft (136).

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