A Highly Sensitive Photonic Crystal Detector
By using a linked break marking mechanism and highly sensitive crystal assembly in the photonic crystal detector, the laser deviation problem caused by the movement of the sample position is solved, the detection accuracy and sensitivity are improved, and the rapid and highly sensitive detection of antibodies is achieved.
Patent Information
- Application Number
- CN202411412862.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-11
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2044-10-11
AI Technical Summary
Existing antibody fluorescence detectors may cause laser irradiation position deviation after moving at the sample position, resulting in inaccurate detection results and insufficient detection sensitivity for low-concentration samples.
A highly sensitive photonic crystal detector is designed, using a linked voltage break marking mechanism and a highly sensitive crystal assembly. Through the cooperation of the arc-shaped baffle and the thrust touch block, the photonic crystal is accurately aligned at the laser irradiation position, and the fluorescent signal is enhanced by irradiation of ultraviolet laser lamps.
It improves the accuracy of detection data, enhances the detection sensitivity of low-concentration samples, can quickly and accurately detect antibodies, and shortens the patient's visit time.
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Figure CN119269464B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of detectors, and in particular to a high-sensitivity photonic crystal detector. Background Art
[0002] The content of biomarkers is closely related to many diseases, so the rapid and timely detection of biomarkers in samples is of great significance for biological analysis, early differential diagnosis and accurate formulation of treatment plans. Currently, rapid antigen tests (RAT) are mostly based on lateral flow immunoassays, which usually can determine whether a positive result is obtained after 15 minutes.
[0003] According to the Chinese authorized patent publication number: CN112082981A, an antibody fluorescence automatic detector is disclosed, including a diluent station, a dilution plate, a pipette head seat, a turntable, a test paper card holder, a card feed assembly, a card ejection assembly and a pipette gun assembly. The pipette gun assembly includes a translation platform that moves between the diluent station, the dilution plate, the pipette head seat and the turntable under the drive of a transverse movement mechanism and a longitudinal movement mechanism; a pipette gun and a pipette gun lifting mechanism that drives the pipette gun to move up and down relative to the translation platform are arranged on the translation platform. Its advantages are: by setting up a pipette tip seat, a pipette assembly, an automatic card feeding assembly and an automatic card ejection assembly, the processes of diluting blood samples, adding samples to test strip cards, changing pipette tips, measuring readings, inserting test strip cards and removing test strip cards are all automatically and intelligently completed, achieving the purpose of large-scale automated measurement, thereby saving a lot of manpower and material resources, and improving detection efficiency and the accuracy of measurement results. However, the antibody detector still has shortcomings. During antibody fluorescence detection, in order to increase the authenticity of biological sample detection, multiple groups of parallel samples and negative and positive controls are usually set for the same batch of biological samples. During the detection process, each photonic crystal needs to be individually aligned and irradiated. However, each time the sample is irradiated, the position of the sample in the same column may deviate from the laser irradiation position after movement, resulting in inaccurate detection results. In addition, there is a lack of effective signal enhancement mechanism. The detection sensitivity for low-concentration samples such as blood or saliva is insufficient, and it is impossible to quickly test whether there are antibodies in the patient's body. Summary of the invention
[0004] In view of the shortcomings of the prior art, the present invention provides a high-sensitivity photonic crystal detector, which solves the problem that after the position of samples in the same column moves during the detection process, deviations from the laser irradiation position may occur, resulting in inaccurate detection results and inability to quickly detect whether antibodies are present in the patient's body.
[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions: a high-sensitivity photonic crystal detector, comprising a detector body, a high-sensitivity crystal component is arranged on the upper surface of the detector body, the high-sensitivity crystal component comprises a detection chip, a thermoplastic polyester layer, a photonic crystal and a connection card pad, the upper surface of the detection chip is coated with a thermoplastic polyester layer, a plurality of photonic crystals are distributed in a matrix between the thermoplastic polyester layer and the detection chip, each of the photonic crystals is composed of a periodic nanostructure with alternating high and low refractive indices, and the detection A plurality of arc-shaped baffles are fixedly connected on both sides of the detection chip, and the arc-shaped baffles on the same side are equidistantly distributed on the sides of the detection chip. A linkage pressure-breaking marking mechanism is arranged on the front side above the detection chip, and the linkage pressure-breaking marking mechanism is used to trigger the limit locking and marking of the detection chip. The linkage pressure-breaking marking mechanism includes an outer bracket, a fixed plate, a reset torsion spring, a push-touch block, an arc-shaped groove, an outer expansion plate, an extrusion contact and an ink storage cylinder. During the detection, the sample is mixed with the virus lysis solution and the fluorescent probe solution, and then multiple drops of the mixed solution are dropped on multiple photons of the detection chip respectively. The detection chip is then pushed to move to the bottom of the ultraviolet laser lamp. In the process of pushing the detection chip, as the detection chip moves backward, multiple arc-shaped baffles located on both sides of the detection chip will be successively stuck in the arc-shaped groove of the push-touch block, and as the detection chip continues to move, the push-touch block rotates inwardly under the action of the arc-shaped baffles. When the outer end of the arc-shaped baffle moves to the rear position of the arc-shaped groove, the extrusion contact on the outside of the push-touch block rotates to the side position between the previous arc-shaped baffle and the next arc-shaped baffle of the detection chip. Under the action of the extrusion contact, on the one hand, it plays a limiting role on the detection chip. At this time, the photonic crystals arranged in the same horizontal direction are just in the same vertical plane as the irradiation position of the laser lamp, which reduces the detection error caused by alignment deviation and improves the accuracy of the detection data. On the other hand, when the extrusion contact is squeezed on the side of the detection chip, the adsorption cotton strip in the extrusion contact leaves ink dot marks on the side of the detection chip, so that it is convenient for subsequent detection personnel to take out the detection chip and determine whether the biological sample on the detection chip has completed the fluorescence detection.
[0006] Preferably, fixed plates are fixedly connected to the left and right ends of the inner side of the outer bracket, and push-touch blocks are rotatably connected to the lower surfaces of the left and right fixed plates. A reset torsion spring is provided at the rotational connection position between the push-touch block and the fixed plate, an arc groove is provided on the inner side of the push-touch block, an outer expansion plate is fixedly connected to the front side of the push-touch block, and an ink storage cylinder is provided on the rear side of the outer expansion plate.
[0007] Preferably, an extrusion contact is provided on the front side of the external expansion plate, an adsorption cotton strip is provided through the middle of the extrusion contact, the rear end of the adsorption cotton strip is provided through the inside of an ink storage cylinder, ink is provided inside the ink storage cylinder, an ink adding hole is provided on the upper surface of the rear end of the ink storage cylinder, a rubber ring is provided on the outer side of the front end of the adsorption cotton strip, and the rubber ring is fixedly connected to the front side of the ink storage cylinder. Since there is a gap between two connected arc-shaped baffles, when the next arc-shaped baffle has not yet entered the arc groove, the push-touch block contacts the torsion of the reset torsion spring and is reset to the initial position. Thereafter, as the detection chip moves, the cycle is repeated, so that each row of photonic crystals on the detection chip can be limited and marked.
[0008] Preferably, a heating rack is fixedly connected between the two fixing plates, and an electric heating plate is arranged on the lower surface of the heating rack.
[0009] Preferably, connection pads are fixedly connected to both left and right sides of the lower surface of the detection chip.
[0010] Preferably, a multi-position detection mechanism is provided on the rear side of the upper surface of the detector body, and the multi-position detection mechanism includes a support arm, a protective cover, a connecting groove, a transmission screw, a transmission slider, a connecting plate and a connecting slide rail. The number of the support arms is set to two, and the two support arms are respectively fixedly connected to the left and right sides of the outer surface of the detector body, and the upper ends of the two support arms are respectively fixedly connected to the left and right sides of the lower surface of the protective cover.
[0011] Preferably, a connecting groove is provided on the front side of the protective cover, a connecting piece is provided through the middle of the connecting groove, a UV laser lamp is fixedly connected to the front end of the connecting piece, and the rear side of the connecting piece is fixedly connected to the front side of the transmission slider.
[0012] Preferably, a transmission screw is horizontally provided in the middle of the transmission slider, and the transmission slider is threadedly connected to the transmission screw, the left and right ends of the transmission screw are respectively rotatably connected to the left and right sides inside the protective cover, the rear end of the transmission slider is slidably connected to the front side of the connecting slide rail, and the connecting slide rail is fixedly connected to the rear side of the protective cover.
[0013] Preferably, a motor is arranged outside the protective cover, and an output end of the motor is drivingly connected to a driving screw.
[0014] Preferably, a boss is fixedly connected to the upper surface of the detector body. Beneficial Effects
[0015] The present invention provides a highly sensitive photonic crystal detector. Compared with the prior art, it has the following beneficial effects:
[0016] In the present invention, a linked pressure-breaking marking mechanism and a high-sensitivity crystal assembly are provided, and during detection, the sample is mixed with a virus lysis solution and a fluorescent probe solution, and then multiple drops of the mixed solution are respectively dropped on multiple photonic crystals of the detection chip, and then the detection chip is pushed to move it below the ultraviolet laser lamp. In the process of pushing the detection chip, as the detection chip moves backward, multiple arc-shaped baffles located on both sides of the detection chip will be sequentially inserted into the arc-shaped groove of the push-touch block, and as the detection chip continues to move, the push-touch block rotates inwardly under the action of the arc-shaped baffles. When the outer end of the arc-shaped baffle moves to the rear position of the arc-shaped groove, the squeezing contact on the outer side of the push-touch block rotates to the side position between the previous arc-shaped baffle and the next arc-shaped baffle of the detection chip. Under the action of the squeezing contact, on the one hand, it plays a role in limiting the detection chip, and at this time, the light arranged at the same level The photonic crystal is just in the same vertical plane as the laser light irradiation position, which reduces the detection error caused by alignment deviation and improves the accuracy of the detection data. On the other hand, when the extrusion contact is squeezed on the side of the detection chip, the adsorption cotton strip in the extrusion contact leaves ink dot marks on the side of the detection chip, which makes it easier for subsequent detection personnel to take out the detection chip and determine whether the biological sample on the detection chip has completed the fluorescence detection. Finally, the mixed liquid is irradiated with an ultraviolet laser light. After the photonic crystal is exposed to the ultraviolet laser light, a photonic band is formed. The photonic crystal is composed of a periodic nanostructure with alternating high and low refractive indices. If the maximum excitation or emission wavelength of the fluorescent substance overlaps with the photonic band gap of the photonic crystal, the detection fluorescence can be significantly enhanced, realizing rapid and highly sensitive detection of antibodies, thereby greatly shortening the patient's consultation time and greatly accelerating the time for patients to start treatment;
[0017] In the present invention, through the multi-position detection mechanism, when different sample mixtures on the detection chip are detected, the transmission screw is driven to rotate by the motor. While the transmission screw rotates, the transmission slider threadedly connected thereto moves in the horizontal direction. The transmission slider drives the ultraviolet laser lamp to move horizontally, so that the sample mixtures at different positions in the same row on the detection chip can be irradiated. During the irradiation process, the front and rear positions of the detection chip can be manually adjusted forward and backward, thereby realizing the detection of the entire sample mixture. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 This is a schematic diagram of the front three-dimensional structure of a high-sensitivity photonic crystal detector proposed by the present invention;
[0019] Figure 2 This is a schematic diagram of the rear three-dimensional structure of a high-sensitivity photonic crystal detector proposed by the present invention;
[0020] Figure 3 A schematic diagram of the structure of a highly sensitive photonic crystal detector proposed by the present invention from an oblique upper perspective;
[0021] Figure 4 A schematic diagram of the structure of a high-sensitivity crystal component in a high-sensitivity photonic crystal detector proposed by the present invention;
[0022] Figure 5 This is a schematic diagram of the front structure of a linkage voltage-break marking mechanism in a high-sensitivity photonic crystal detector proposed by the present invention;
[0023] Figure 6 This is a schematic diagram of the rear structure of a linkage voltage-break marking mechanism in a high-sensitivity photonic crystal detector proposed by the present invention;
[0024] Figure 7 A schematic structural diagram of a central linkage breaking pressure marking mechanism in a high-sensitivity photonic crystal detector proposed by the present invention from an oblique upper perspective;
[0025] Figure 8 This is a schematic diagram of the structure of a push-touch block in a high-sensitivity photonic crystal detector proposed by the present invention.
[0026] Legend:
[0027] 1. Detection instrument body; 2. High-sensitivity crystal assembly; 201. Detection chip; 202. Thermoplastic polyester layer; 203. Photonic crystal; 204. Connecting card pad; 205. Arc-shaped baffle; 3. Multi-position detection mechanism; 301. Support arm; 302. Protective cover; 303. Connecting groove; 304. Transmission screw; 305. Transmission slider; 306. Connecting piece; 307. Connecting slide rail; 308. Motor; 4. Boss; 5. Ultraviolet laser lamp; 6. Linkage pressure-breaking marking mechanism; 601. External bracket; 602. Fixed plate; 603. Reset torsion spring; 604. Push-action block; 605. Arc-shaped groove; 606. External expansion plate; 607. Extrusion contact; 608. Adsorption cotton strip; 609. Ink storage cylinder; 610. Rubber ring; 611. Heating rack; 612. Electric heating plate. DETAILED DESCRIPTION
[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0029] See also Figure 1-Figure 8 The present invention provides two technical solutions, which specifically include the following embodiments: Embodiment 1:
[0030] A high-sensitivity photonic crystal detector comprises a detector body 1, a high-sensitivity crystal assembly 2 is arranged on the upper surface of the detector body 1, the high-sensitivity crystal assembly 2 comprises a detection chip 201, a thermoplastic polyester layer 202, a photonic crystal 203 and a connection card pad 204, the upper surface of the detection chip 201 is coated with a thermoplastic polyester layer 202, a plurality of photonic crystals 203 are distributed in a matrix between the thermoplastic polyester layer 202 and the detection chip 201, each photonic crystal 203 is composed of a periodic nanostructure with alternating high and low refractive indices, it should be noted that due to the structural characteristics of the photonic crystal 203, the photons emitted by the fluorescent substance are repeatedly reflected and refracted in the photonic crystal 203, if the maximum excitation or emission wavelength of the fluorescent probe is the same as the photon The photonic band gaps of the crystals 203 overlap, and the photonic crystals 203 will enhance the emission of the fluorescent signal. A plurality of photonic crystals 203 are distributed in a matrix between the thermoplastic polyester layer 202 and the detection chip 201. A plurality of arc-shaped baffles 205 are fixedly connected to both sides of the detection chip 201, and the arc-shaped baffles 205 on the same side are equidistantly distributed on the sides of the detection chip 201. A linkage pressure-breaking marking mechanism 6 is arranged on the front side above the detection chip 201. The linkage pressure-breaking marking mechanism 6 is used to trigger the limit locking and marking of the detection chip 201. The linkage pressure-breaking marking mechanism 6 includes an outer bracket 601, a fixed plate 602, a reset torsion spring 603, a push trigger block 604, an arc-shaped groove 605, an outer expansion plate 606, an extrusion contact 607 and an ink storage cylinder 609. The outer bracket The left and right ends of the inner side of 601 are fixedly connected with fixed plates 602, and the lower surfaces of the left and right fixed plates 602 are rotatably connected with push-touch blocks 604. A reset torsion spring 603 is provided at the rotational connection position between the push-touch block 604 and the fixed plate 602. When an arc-shaped baffle 205 on the outer side of the detection chip 201 leaves the arc-shaped groove 605 of the push-touch block 604, due to the gap between the two connected arc-shaped baffles 205, before the next arc-shaped baffle 205 enters the arc-shaped groove 605, the push-touch block 604 contacts the torsion of the reset torsion spring 603 and resets to the initial position, and then moves with the detection chip 201, and repeats in this way, so that each row of photonic crystals 203 on the detection chip 201 can be limited and marked. An arc groove 605 is provided on the inner side of the push-touch block 604, an outward expansion plate 606 is fixedly connected to the front side of the push-touch block 604, an ink storage cylinder 609 is arranged on the rear side of the outward expansion plate 606, an extrusion contact 607 is arranged on the front side of the outward expansion plate 606, an adsorption cotton strip 608 is arranged through the middle of the extrusion contact 607, the rear end of the adsorption cotton strip 608 is arranged through the inside of the ink storage cylinder 609, the inside of the ink storage cylinder 609 is provided with ink, an ink adding hole is arranged on the upper surface of the rear end of the ink storage cylinder 609, a rubber ring 610 is arranged on the outer side of the front end of the adsorption cotton strip 608, and the rubber ring 610 is fixedly connected to the front side of the ink storage cylinder 609, a heating frame 611 is fixedly connected between the two fixed plates 602, and an electric heating plate 612 is arranged on the lower surface of the heating frame 611.
[0031] During operation, the sample is mixed with the virus lysis solution and the fluorescent probe solution during detection, and then multiple drops of the mixed solution are dropped on multiple photonic crystals 203 of the detection chip 201 respectively, and then the detection chip 201 is pushed to move it below the ultraviolet laser lamp 5. In the process of pushing the detection chip 201, as the detection chip 201 moves backward, multiple arc-shaped baffles 205 located on both sides of the detection chip 201 will be sequentially inserted into the arc grooves 605 of the push trigger block 604, and as the detection chip 201 moves backward, the arc-shaped baffles 205 located on both sides of the detection chip 201 will be sequentially inserted into the arc-shaped ... As the chip 201 continues to move, the push-touch block 604 rotates inwardly under the action of the arc-shaped baffle 205. When the outer end of the arc-shaped baffle 205 moves to the rear side of the arc-shaped slot 605, the extrusion contact 607 on the outer side of the push-touch block 604 rotates to the side position between the previous arc-shaped baffle 205 and the next arc-shaped baffle 205 of the detection chip 201. Under the action of the extrusion contact 607, on the one hand, it plays a role in limiting the detection chip 201. At this time, the same level The arranged photonic crystals 203 are just in the same vertical plane as the laser light irradiation position, which reduces the detection error caused by alignment deviation and improves the accuracy of the detection data. On the other hand, when the extrusion contact 607 is squeezed on the side of the detection chip 201, the adsorption cotton strip 608 in the extrusion contact 607 leaves an ink dot mark on the side of the detection chip 201, so that it is convenient for subsequent detection personnel to take out the detection chip 201 and determine whether the biological sample on the detection chip 201 has completed the fluorescence detection. The ultraviolet laser light 5 irradiates the mixed liquid, and the photonic crystal 203 is formed by the ultraviolet laser light 5. The photonic crystal 203 is composed of a periodic nanostructure with alternating high and low refractive indices. If the maximum excitation or emission wavelength of the fluorescent substance overlaps with the photonic band gap of the photonic crystal 203, the detection fluorescence can be significantly enhanced, and rapid and highly sensitive detection of antibodies can be achieved, thereby greatly shortening the patient's consultation time and greatly accelerating the time for patients to start treatment. Embodiment 2:
[0032] On the basis of the first embodiment, the left and right sides of the lower surface of the detection chip 201 are fixedly connected with connecting pads 204, the upper surface of the detection instrument body 1 is fixedly connected with a boss 4, and a multi-position detection mechanism 3 is arranged on the rear side of the upper surface of the detection instrument body 1. The multi-position detection mechanism 3 includes a support arm 301, a protective cover 302, a connecting groove 303, a transmission screw 304, a transmission slider 305, a connecting piece 306 and a connecting slide rail 307. The number of the support arms 301 is set to two, and the two support arms 301 are respectively fixedly connected to the left and right sides of the outer surface of the detection instrument body 1, and the upper ends of the two support arms 301 are respectively fixedly connected to the left and right sides of the lower surface of the protective cover 302. A connecting groove 303 is opened on the front side of the protective cover 302, and a connecting piece 306 is arranged through the middle of the connecting groove 303. The front end of the connecting piece 306 is fixedly connected to the ultraviolet laser lamp 5, and the rear side of the connecting piece 306 is fixedly connected to the front side of the transmission slider 305. A transmission screw 304 is arranged horizontally through the middle of the transmission slider 305. A thread is arranged in the middle of the movable slider 305, and the transmission slider 305 is threadedly connected with the transmission screw 304, and the left and right ends of the transmission screw 304 are respectively rotatably connected to the left and right sides inside the protective cover 302, and the rear end of the transmission slider 305 is slidably connected to the front side of the connecting slide rail 307, and the connecting slide rail 307 is fixedly connected to the rear side of the protective cover 302. A motor 308 is arranged on the outside of the protective cover 302, and the output end of the motor 308 is transmission-connected with the transmission screw 304. When different sample mixtures on the detection chip 201 are detected, the transmission screw 304 is driven to rotate by the motor 308. While the transmission screw 304 rotates, the transmission slider 305 threadedly connected thereto moves in a horizontal direction, and the ultraviolet laser lamp 5 is driven to move horizontally by the transmission slider 305, so that the sample mixtures at different positions in the same row on the detection chip 201 can be irradiated. During the irradiation process, the front and rear positions of the detection chip 201 can be manually adjusted back and forth, so as to realize the detection of the entire sample mixture.
[0033] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the application should be included in the protection scope of the present application.
Claims
1. A highly sensitive photonic crystal detector, comprising a detector body (1), characterized in that: The upper surface of the detector body (1) is provided with a high-sensitivity crystal component (2), the high-sensitivity crystal component (2) is used to enhance the detection sensitivity of antibodies, the high-sensitivity crystal component (2) comprises a detection chip (201), a thermoplastic polyester layer (202), a photonic crystal (203) and a connection card pad (204), the upper surface of the detection chip (201) is coated with a thermoplastic polyester layer (202), a plurality of photonic crystals (203) are distributed in a matrix between the thermoplastic polyester layer (202) and the detection chip (201), and both sides of the detection chip (201) are fixedly connected to There are a plurality of arc-shaped baffles (205), and the arc-shaped baffles (205) on the same side are equidistantly distributed on the side of the detection chip (201); a linkage pressure-breaking marking mechanism (6) is arranged on the front side above the detection chip (201); the linkage pressure-breaking marking mechanism (6) is used to trigger the detection chip (201) to limit lock and mark, and the linkage pressure-breaking marking mechanism (6) comprises an outer bracket (601), a fixing plate (602), a reset torsion spring (603), a push-actuating block (604), an arc-shaped groove (605), an outer expansion plate (606), a squeeze contact (607) and an ink storage cylinder (609); A multi-position detection mechanism (3) is arranged on the rear side of the upper surface of the detection instrument body (1), and the multi-position detection mechanism (3) comprises a support arm (301), a protective cover (302), a connecting groove (303), a transmission screw (304), a transmission slider (305), a connecting piece (306) and a connecting slide rail (307), the number of the support arms (301) being two, the two support arms (301) being respectively fixedly connected to the left and right sides of the outer surface of the detection instrument body (1), and the upper ends of the two support arms (301) being respectively fixedly connected to the left and right sides of the lower surface of the protective cover (302); A connecting groove (303) is provided on the front side of the protective cover (302), a connecting piece (306) is provided through the middle of the connecting groove (303), a front end of the connecting piece (306) is fixedly connected to the ultraviolet laser lamp (5), and a rear side of the connecting piece (306) is fixedly connected to the front side of the transmission slider (305).
2. A highly sensitive photonic crystal detector according to claim 1, characterized in that: The left and right ends of the inner side of the outer bracket (601) are fixedly connected to fixed plates (602), the lower surfaces of the left and right fixed plates (602) are rotatably connected to push-touch blocks (604), a return torsion spring (603) is provided at the rotatably connected position between the push-touch block (604) and the fixed plate (602), an arc groove (605) is provided on the inner side of the push-touch block (604), the front side of the push-touch block (604) is fixedly connected to an outer expansion plate (606), and an ink storage cylinder (609) is provided on the rear side of the outer expansion plate (606).
3. A highly sensitive photonic crystal detector according to claim 2, characterized in that: An extrusion contact (607) is arranged on the front side of the outer expansion plate (606), an adsorption cotton strip (608) is arranged through the middle of the extrusion contact (607), the rear end of the adsorption cotton strip (608) is arranged through the inside of the ink storage cylinder (609), the inside of the ink storage cylinder (609) is provided with ink, and an ink adding hole is arranged on the upper surface of the rear end of the ink storage cylinder (609), and a rubber ring (610) is arranged on the outer side of the front end of the adsorption cotton strip (608), and the rubber ring (610) is fixedly connected to the front side of the ink storage cylinder (609).
4. A highly sensitive photonic crystal detector according to claim 2, characterized in that: A heating rack (611) is fixedly connected between the two fixing plates (602), and an electric heating plate (612) is provided on the lower surface of the heating rack (611).
5. A highly sensitive photonic crystal detector according to claim 4, characterized in that: Connecting pads (204) are fixedly connected to both left and right sides of the lower surface of the detection chip (201).
6. A highly sensitive photonic crystal detector according to claim 1, characterized in that: A transmission screw rod (304) is disposed transversely through the middle of the transmission slider (305), and the transmission slider (305) is threadedly connected to the transmission screw rod (304). The left and right ends of the transmission screw rod (304) are rotatably connected to the left and right sides of the inside of the protective cover (302), respectively. The rear end of the transmission slider (305) is slidably connected to the front side of the connecting slide rail (307), and the connecting slide rail (307) is fixedly connected to the rear side of the protective cover (302).
7. A highly sensitive photonic crystal detector according to claim 6, characterized in that: A motor (308) is arranged outside the protective cover (302), and an output end of the motor (308) is drivingly connected to a driving screw rod (304).
8. A highly sensitive photonic crystal detector according to claim 1, characterized in that: A boss (4) is fixedly connected to the upper surface of the detector body (1).
Citation Information
Patent Citations
Automatic antibody fluorescence detector
CN112082981A
Metal-modified photonic crystal biological detection film as well as preparation method and application thereof
CN102072891A
Photon crystal micro-ball based multicomponent immunity detection method
CN1928561A