Application of lavender essential oil in preparation of product for treating / relieving skin keloid

Abstract

The invention provides application of a compound product of lavender essential oil and jojoba oil to preparation of a product for treating / repairing keloid on skin.

Description

Technical Field

[0001] The invention relates to a product for keloid, and in particular to application of lavender essential oil in preparing a product for treating / relieving skin keloid. Background Art

[0002] Keloid is a pathological scar tissue secondary to skin trauma or spontaneously formed and overgrown. Its characteristics include lesions exceeding the scope of the original skin injury, continuous growth, and the appearance of nodular, cord-like or sheet-like mass-like tissue that is higher than the skin surface, hard, tough and congested. Clinically, keloids are observed to be difficult to cure and have a high recurrence rate. Surgical excision combined with postoperative radiotherapy is one of the main methods for treating keloids, with an effective rate of about 70%. However, after the end of radiotherapy, it is often accompanied by adverse reactions such as dry skin, itching, and uneven pigmentation in the irradiated area. There is also a recurrence rate of about 30%, and the recovery of postoperative scars does not achieve the ideal effect, which is still a certain gap from the patient's psychological cosmetic expectations. There is currently no relief or treatment plan for this type of refractory keloid. Summary of the invention

[0003] The present invention aims to overcome the above-mentioned defects and provide a method for treating keloids, in particular, a solution for keloids after radiotherapy and related adverse reactions.

[0004] The present invention provides application of a composite product of lavender essential oil and jojoba oil in preparing a product for treating / repairing keloids on the skin.

[0005] The present invention provides application of a compound product of lavender essential oil and jojoba oil in preparing a product for inhibiting the recurrence of keloid.

[0006] The present invention provides application of a composite product of lavender essential oil and jojoba oil in preparing a product for promoting wound healing and alleviating pigment deposition.

[0007] The present invention provides application of a composite product of lavender essential oil and jojoba oil in preparing a product for relieving dry skin and itching.

[0008] The present invention provides application of a compound product of lavender essential oil and jojoba oil in preparing a product for treating / repairing refractory keloids.

[0009] The present invention provides application of a composite product of lavender essential oil and jojoba oil in preparing a product for inhibiting the recurrence of refractory keloids.

[0010] The present invention provides the use of a composite product of lavender essential oil and jojoba oil in preparing a product for treating / repairing / alleviating refractory keloids and related adverse reactions after electron beam irradiation after surgery.

[0011] The present invention provides application of a composite product of lavender essential oil and jojoba oil in preparing a product for inhibiting the recurrence of refractory keloids after postoperative electron beam irradiation.

[0012] In the above application, the volume ratio of lavender essential oil to jojoba oil is 1:2-4.

[0013] The preparation process of the above-mentioned lavender essential oil is as follows:

[0014] S1. Lavender distillation: The high temperature of the steam generated in the steamer is used to gradually rupture the oil gland cells in the stems and leaves of the lavender flowers, allowing the essential oil contained in the oil gland cells to gradually penetrate from inside and outside the tissues into the intercellular spaces. After reaching the surface of the stems and leaves, the essential oil is transformed into an oil-gas mixture together with the steam. The steam rises to the outlet of the steamer and enters the condenser. The cooling water outside the condenser fully cools the oil-gas mixture into an oil-water mixture.

[0015] S2. Cooling water temperature control standard: Lavender essential oil is extracted by steam distillation, with air delivered through a boiler at a pressure of 0.4-0.6MPa;

[0016] S3. Collect oil: The mixed liquid flows out from the other end of the condenser and enters the oil-water separator. Due to the different specific gravities of oil and water, the oil floats on the top and the water is at the bottom. Close the outlet valve of the oil-water separator to allow the lavender essential oil to flow into the oil storage tank. DETAILED DESCRIPTION

[0017] The present invention can be implemented in a variety of ways and can have various embodiments, so each specific embodiment is illustrated and described. However, this is not intended to limit the present invention to a specific implementation, but should be understood to include all changes, equivalents and even substitutes that fall within the concept and technical scope of the present invention.

[0018] Example 1. Preparation of the compound:

[0019] Lavender essential oil and jojoba oil were mixed in different ratios of 1:1; 1:2, 1:3, 1:4, 1:5, 0:1 (i.e., a group without lavender essential oil), and 1:0 (i.e., a group without jojoba oil) to form experimental group 1 (1:1), experimental group 2 (1:2), experimental group 3 (1:3), experimental group 4 (1:4), experimental group 5 (1:5), experimental group 6 (0:1) and experimental group 7 (1:0).

[0020] As for lavender essential oil and jojoba oil, commercially available products may be used.

[0021] Lavender essential oil can also be obtained through the following process:

[0022] S1. Lavender distillation: The high temperature of the steam generated in the steamer is used to gradually rupture the oil gland cells in the stems and leaves of the lavender flowers, allowing the essential oil contained in the oil gland cells to gradually penetrate from the inside and outside of the tissue into the intercellular space. After reaching the surface of the stems and leaves, it is transformed into an oil-gas mixture together with the steam. The steam rises to the outlet of the steamer and enters the condenser. The cooling water outside the condenser fully cools the oil-gas mixture into an oil-water mixture.

[0023] S2. Cooling water temperature control standard: Lavender essential oil is extracted by steam distillation, with air delivered through a boiler (air pressure is 0.4-0.6MPa).

[0024] S3. Collecting oil: The mixed liquid flows out from the other end of the condenser and enters the oil-water separator. Due to the different specific gravities of oil and water, the oil floats on the top and the water is at the bottom. The outlet valve of the oil-water separator is closed, and the lavender oil flows into the oil storage tank. Finally, the operator uses a stainless steel bucket to collect the lavender oil from the oil storage tank.

[0025] Experimental Example 2. Patient Experiment with Different Ratios of Lavender Essential Oil and Jojoba Oil

[0026] Experimental methods:

[0027] A total of 70 patients with refractory keloids who visited our hospital and related institutions were selected, and 10 patients were randomly assigned to a group, for a total of 7 experimental groups.

[0028] KLD0101-KLD0110, corresponding to experimental group 1;

[0029] KLD0201-KLD0210, corresponding to experimental group 2;

[0030] KLD0301-KLD0310, corresponding to experimental group 3;

[0031] KLD0401-KLD0410, corresponding to experimental group 4;

[0032] KLD0501-KLD0510, corresponding to experimental group 5;

[0033] KLD0601-KLD0610, corresponding to experimental group 6;

[0034] KLD0701-KLD0710, corresponding to experimental group 7;

[0035] Each patient underwent scar excision in advance, and surgical specimens were taken and sent for immunohistochemistry testing. All patients received electron beam irradiation (20Gy / 5Gy / 4F) after surgery, and were randomly assigned to 7 experimental groups after radiotherapy. Starting from the second day after the incision healed after radiotherapy, they received essential oil products with different formula ratios, one dropper (about 1-2ml) soaked in gauze to cover the surgical incision for 30 minutes every day, and the course of treatment was 1 month.

[0036] Observations and indicators:

[0037] The keloid condition was recorded before surgery, and the Vancouver Scar Score (VSS) and Visual Analog Scale (VAS) were used to evaluate the scar and pain degree. After radiotherapy, the patients were followed up regularly to record the adverse reactions such as local swelling, pain, edema, burning, etc. of the incision, the healing time of the incision, and the pain relief time. VSS and VAS were evaluated again one month after the end of treatment.

[0038] The efficacy was evaluated one year after the treatment: the Darzi keloid efficacy evaluation criteria were used for efficacy evaluation: the surgical incision scar was flat, and the original itching and pain and other abnormal sensations disappeared, which was considered to be effective; the postoperative incision scar was smaller, softer, and flatter than before, and the original itching and pain were reduced, which was considered effective; the scar recurred, with no obvious change or aggravation compared to before treatment, which was considered ineffective.

[0039]

[0040]

[0041]

[0042]

[0043] * Effective rate = (markedly effective + effective) / all patients in the group × 100%. P < 0.05.

[0044] From the above results, it can be found that the therapeutic effect is best under the conditions of lavender essential oil + jojoba oil at a ratio of 1:3 or 1:4.

[0045] Experimental Example 3. Patient Experiments with Different Compounding Schemes

[0046] Comparison group:

[0047] Comparative group 1. 50 parts of lavender essential oil, 20 parts of beeswax, 200 parts of lithospermum, 200 parts of astragalus, 200 parts of angelica, 200 parts of angelica dahurica and 200 parts of bletilla striata. (1) Take lithospermum, astragalus and bletilla striata, add 10 times the volume of mixed medicine in water, soak for 0.5h, decoct for 1.5h, filter to obtain the first extract; (2) Take angelica and angelica dahurica, add 8 times the volume of mixed medicine with 75% ethanol, reflux extraction for 3h, filter to obtain the second extract and volatile oil, mix the first extract and the second extract, and then concentrate to obtain an extract with a relative density of 1.25; (3) Add lavender essential oil, beeswax, volatile oil and auxiliary materials in step (2) to the extract of step (2), mix well, and prepare a dressing.

[0048] Comparative group 2. 10 parts of lavender essential oil, 20 parts of beeswax, 200 parts of lithospermum officinale, 200 parts of astragalus, 200 parts of angelica, 200 parts of angelica dahurica and 200 parts of bletilla striata. Methods Comparative group 1.

[0049] Comparative group 3. 40 parts of lavender essential oil, 10 parts of jojoba oil, 20 parts of beeswax, 200 parts of lithospermum officinale, 200 parts of astragalus, 200 parts of angelica, 200 parts of angelica dahurica and 200 parts of bletilla striata. Methods Comparative group 1.

[0050] Comparative group 4. 10 parts of lavender essential oil, 40 parts of jojoba oil, 20 parts of beeswax, 200 parts of lithospermum officinale, 200 parts of astragalus, 200 parts of angelica, 200 parts of angelica dahurica and 200 parts of bletilla striata. Methods Comparative group 1.

[0051] Experimental methods:

[0052] Forty patients with refractory keloids who visited our hospital and related institutions were selected, and 10 patients were randomly assigned to a group, for a total of 4 experimental groups.

[0053] KLDB101-KLDB110 correspond to comparison group 1;

[0054] KLDB201-KLDB210 correspond to comparison group 2;

[0055] KLDB301-KLDB310 correspond to comparison group 3;

[0056] KLDB401-KLDB410 correspond to comparison group 4;

[0057] Each patient underwent scar excision in advance, and surgical specimens were taken and sent for immunohistochemistry testing. All patients received electron beam irradiation (20Gy / 5Gy / 4F) after surgery, and were randomly assigned to 4 experimental groups after radiotherapy. Starting from the second day after the incision healed after radiotherapy, one dropper (about 1-2ml) was soaked in gauze / dressing to cover the surgical incision for 30 minutes every day, and the course of treatment was 1 month.

[0058] Observations and indicators:

[0059] The surgical scar tissue was sent for examination to detect indicators such as E-cadherin, Vimentin, and procollagen content.

[0060] The keloid condition was recorded before surgery, and the Vancouver Scar Score (VSS) and Visual Analog Scale (VAS) were used to evaluate the scar and pain degree. After radiotherapy, the patients were followed up regularly to record the adverse reactions such as local swelling, pain, edema, burning, etc. of the incision, the healing time of the incision, and the pain relief time. VSS and VAS were evaluated again one month after the end of treatment.

[0061] The efficacy was evaluated one year after the treatment: the Darzi keloid efficacy evaluation criteria were used for efficacy evaluation: the surgical incision scar was flat, and the original itching and pain and other abnormal sensations disappeared, which was considered to be effective; the postoperative incision scar was smaller, softer, and flatter than before, and the original itching and pain were reduced, which was considered effective; the scar recurred, with no obvious change or aggravation compared to before treatment, which was considered ineffective.

[0062]

[0063]

[0064]

[0065] * Effective rate = (markedly effective + effective) / all patients in the group × 100%. P < 0.05.

[0066] From the above results, it can be found that the addition of Chinese herbal ingredients such as astragalus that have anti-inflammatory effects does not provide better therapeutic effects.

[0067] Although the above description is centered on the embodiment, it is only an example and does not limit the present invention. It is clear to those skilled in the art that various modifications and applications not illustrated above can be made within the scope of the essential characteristics of the present embodiment. For example, each component specifically shown in the embodiment can be implemented after being modified. Moreover, various differences related to such modifications and applications should be interpreted as being included in the scope of the present invention as defined in the attached claims.

Claims

1. Application of a compound product of lavender essential oil and jojoba oil in the preparation of a product for skin treatment / repair of keloids.

2. Application of the compound product of lavender essential oil and jojoba oil in the preparation of products for inhibiting the recurrence of keloids.

3. Application of the compound product of lavender essential oil and jojoba oil in the preparation of products for promoting wound healing and reducing pigmentation.

4. Application of the compound product of lavender essential oil and jojoba oil in the preparation of products for relieving dry and itchy skin.

5. Application of a compound product of lavender essential oil and jojoba oil in the preparation of products for treating / repairing refractory keloids.

6. Application of a compound product of lavender essential oil and jojoba oil in the preparation of a product for inhibiting the recurrence of refractory keloids.

7. Application of a compound product of lavender essential oil and jojoba oil in the preparation of a product for treating / repairing refractory keloids after postoperative electron beam irradiation.

8. Application of a compound product of lavender essential oil and jojoba oil in the preparation of a product for inhibiting the recurrence of refractory keloids after postoperative electron beam irradiation.

9. The use according to any one of claims 1 to 8, characterized in that: The volume ratio of the lavender essential oil to the jojoba oil is 1:2-4.

10. The use according to any one of claims 1 to 8, characterized in that: The preparation process of the lavender essential oil is as follows: S1. Lavender distillation: The high temperature of the steam generated in the steamer is used to gradually rupture the oil gland cells in the stems and leaves of the lavender flowers, allowing the essential oil contained in the oil gland cells to gradually penetrate from inside and outside the tissues into the intercellular spaces. After reaching the surface of the stems and leaves, the essential oil is transformed into an oil-gas mixture together with the steam. The steam rises to the outlet of the steamer and enters the condenser. The cooling water outside the condenser fully cools the oil-gas mixture into an oil-water mixture. S2. Cooling water temperature control standard: Lavender essential oil is extracted by steam distillation, with air delivered through a boiler at a pressure of 0.4-0.6MPa; S3. Collect oil: The mixed liquid flows out from the other end of the condenser and enters the oil-water separator. Due to the different specific gravities of oil and water, the oil floats on the top and the water is at the bottom. Close the outlet valve of the oil-water separator to allow the lavender essential oil to flow into the oil storage tank.

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