A vascular guidewire for therapeutic surgery

Abstract

The invention discloses a vascular guidewire for treatment surgery. The invention provides a first marking cavity and a second marking cavity which are coaxially arranged. The cross section of the second marking cavity perpendicular to the axis is in the shape of a circular ring. The outer diameter of the circular ring cross section is smaller than the outer diameter of the guidewire. The inner diameter of the circular ring cross section is larger than the outer diameter of the cross section of the first marking cavity perpendicular to the axis. T1 contrast agent and T2 contrast agent are respectively encapsulated in the first marking cavity and the second marking cavity. The T1 contrast agent and T2 contrast agent are respectively coaxially arranged, so that regions with different brightness on the contrast image can distinguish the shape of the blood vessel according to the different brightness, thereby ensuring the contrast effect and avoiding the defect that the contrast effect is not obvious due to the diversity of the blood vessel shape during the contrast process. Wu in the T1 contrast agent has a high atomic number and a high relaxation efficiency, can significantly shorten the T1 relaxation time, and improve the brightness of the contrast image of the T1 contrast agent.

Description

Technical Field

[0001] The invention relates to the technical field of angiography guidewires, in particular to a vascular guidewire used for therapeutic surgery. Background Art

[0002] Cardiovascular disease is a major health problem worldwide. Vascular surgery, as the primary or auxiliary treatment for cardiovascular disease, has a wide range of application needs. Before vascular surgery, MRI angiography can be used to comprehensively evaluate vascular lesions and help doctors develop more accurate and safer surgical plans.

[0003] MRI, the full name of which is Magnetic Resonance Imaging, uses a strong magnetic field and radio frequency pulses to make the hydrogen nuclei in human tissue resonate and generate signals. These signals are processed by a computer to form a clear image of the internal structure of the human body. Because different tissues in the human body contain different numbers and types of hydrogen nuclei, they will show different signal intensities on the MRI image, so that different tissue types can be distinguished. MRI imaging can clearly display the morphology, structure and blood flow of blood vessels. It is of great value in the diagnosis of vascular diseases such as vascular stenosis, blockage, aneurysm, arteriovenous fistula, etc. It can evaluate the effect of vascular surgery and predict possible complications after surgery.

[0004] During angiography, an angiography guide wire is required to assist in the delivery of contrast agents to complete angiography. However, vascular diseases may cause thickening and hardening of the blood vessel walls, making it difficult for the contrast agent to evenly display the blood vessel condition, resulting in unclear imaging and affecting the imaging effect.

[0005] Therefore, it is necessary to improve the angiography guidewire in the prior art to solve the above problems. Summary of the invention

[0006] The present invention overcomes the deficiencies of the prior art and provides a vascular guidewire for therapeutic surgery.

[0007] To achieve the above object, the technical solution adopted by the present invention is: a vascular guidewire for treatment surgery, comprising: a guidewire substrate, and a marking cavity arranged on the guidewire substrate:

[0008] The marking cavity comprises: a first marking cavity, and a second marking cavity coaxially arranged with the first marking cavity, the outer contour of the cross section of the angiography guide wire perpendicular to the axis is circular, the first marking cavity coincides with the axis of the angiography guide wire, and the axis of the first marking cavity passes through the centroid of the outer contour of the first marking cavity cross section perpendicular to the axis of the first marking cavity;

[0009] The cross section of the second marking cavity perpendicular to the axis is a circular ring, and the inner diameter of the circular ring cross section is larger than the maximum outer diameter of the cross section of the first marking cavity perpendicular to the axis, the outer diameter of the circular ring cross section is smaller than the outer diameter of the cross section of the angiography guide wire perpendicular to the axis, the length of the second marking cavity is smaller than the length of the first marking cavity, and the first marking cavity and the second marking cavity are respectively encapsulated with T1 contrast agent and T2 contrast agent.

[0010] In a preferred embodiment of the present invention, the diameter of the angiography guidewire is 0.25-0.89 mm, and the length is 110-350 cm. The angiography guidewire includes a body section and a head section, and the length of the head section is 30-40 cm.

[0011] In a preferred embodiment of the present invention, the tube body section includes an inner layer and an outer layer, the inner layer and the outer layer are fixedly connected, the outer layer is made of PTFE and a hydrophilic material, and the hydrophilic material is one of zirconium oxide, polyvinyl alcohol and polyethylene glycol.

[0012] In a preferred embodiment of the present invention, the material components of the inner layer include: PTFE, TPU and Wu.

[0013] In a preferred embodiment of the present invention, the components of the T1 contrast agent are: TPU, an enhancer and BiSO4, the enhancer contains Wu and the mass proportion of WU is greater than or equal to 40%.

[0014] In a preferred embodiment of the present invention, the component of the T2 contrast agent is a superparamagnetic ferroferric oxide particle liquid with a concentration of 5-10 mg / ml.

[0015] In a preferred embodiment of the present invention, there is an overlapping portion between the first marking cavity and the second marking cavity along the axial direction, and the length dimension of the second marking cavity is greater than the length dimension of the overlapping portion.

[0016] In a preferred embodiment of the present invention, the cross-sectional shape of the first marking cavity can be one of an equilateral triangle, an ellipse and a square.

[0017] In a preferred embodiment of the present invention, the mass ratio between the T1 contrast agent encapsulated in the first marking cavity and the T2 contrast agent encapsulated in the second marking cavity is 6-10:1.

[0018] In a preferred embodiment of the present invention, the radial dimensions of the first marking cavity and the second marking cavity along the axial direction remain unchanged.

[0019] The present invention solves the defects existing in the background technology and has the following beneficial effects:

[0020] (1) The present invention provides a vascular guidewire for therapeutic surgery, which comprises a first marking cavity and a second marking cavity which are coaxially arranged. The cross-sectional shape of the second marking cavity perpendicular to the axis is a circular ring, the outer diameter of the circular ring cross-sectional shape is smaller than the outer diameter of the guidewire, and the inner diameter of the circular ring cross-sectional shape is larger than the outer diameter of the cross-sectional shape of the first marking cavity perpendicular to the axis. The first marking cavity and the second marking cavity are respectively encapsulated with a T1 contrast agent and a T2 contrast agent. By coaxially arranging the T1 contrast agent and the T2 contrast agent, respectively, the angiographic image has areas with different brightness. Compared with the angiography guidewire in the prior art, the shape of the blood vessel can be distinguished according to different brightness, the shape of the blood vessel can be clearly displayed, the angiography effect is ensured, and the defect that the diversity of the blood vessel shape during the angiography process makes the angiography effect unclear is avoided.

[0021] (2) In the present invention, the angiography guidewire includes a tube body section and a head section, the tube body section includes an inner layer and an outer layer, the inner layer and the outer layer are fixedly connected, the outer layer is made of PTFE and a hydrophilic material, the hydrophilic material is one of zirconium oxide, polyvinyl alcohol and polyethylene glycol. Compared with the prior art, the hydrophilic material has good lubricity and can reduce the friction resistance of the guidewire in the blood vessel. The high strength and corrosion resistance of PTFE further improve the overall strength of the guidewire, thereby ensuring stability during the angiography process.

[0022] (3) In the present invention, the components of the T1 contrast agent are: TPU, an enhancer and BiSO4, the enhancer contains Wu and the mass proportion of WU is greater than or equal to 40%. The T1 contrast agent can enhance the T1 relaxation time of tissues in MRI and make the image brighter. Compared with the prior art, Wu has a higher relaxation efficiency due to its high atomic number, can significantly shorten the T1 relaxation time, and improve the brightness of the contrast image of the T1 contrast agent.

[0023] (4) In the present invention, there are overlapping parts between the first marking cavity and the second marking cavity along the axial direction, and the length of the second marking cavity is greater than the length of the overlapping parts, and the length of the second marking cavity is less than the length of the first marking cavity. There are overlapping parts between the first marking cavity and the second marking cavity, and each has a non-overlapping part. Compared with the prior art, the depth of the guide wire in the body can be accurately indicated, and different types of contrast agents can be used for contrast treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative work.

[0025] Figure 1 is a cross-sectional view of a guidewire according to a preferred embodiment of the present invention;

[0026] Figure 2 is a cross-sectional view of a guidewire according to a first embodiment of a preferred embodiment of the present invention;

[0027] Figure 3 is a cross-sectional view of a guide wire according to a second preferred embodiment of the present invention;

[0028] Figure 4 is a cross-sectional view of a guidewire according to a third preferred embodiment of the present invention;

[0029] In the figure: 100, guide wire base; 200, marking cavity; 210, first marking cavity; 220, second marking cavity. DETAILED DESCRIPTION

[0030] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein. Therefore, the protection scope of the present invention is not limited to the specific embodiments disclosed below.

[0032] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the scope of protection of the present application. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the invention, unless otherwise specified, "multiple" means two or more.

[0033] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood by specific circumstances.

[0034] like Figure 1 As shown, a vascular guidewire for treatment surgery includes: a guidewire base 100, and a marking cavity 200 arranged on the guidewire base 100:

[0035] The marking cavity 200 includes: a first marking cavity 210, and a second marking cavity 220 coaxially arranged with the first marking cavity 210, the outer contour of the cross section of the angiography guide wire perpendicular to the axis is circular, the first marking cavity 210 coincides with the axis of the angiography guide wire, and the axis of the first marking cavity 210 passes through the centroid of the outer contour of the first marking cavity 210 in the cross section perpendicular to the axis of the first marking cavity 210;

[0036] The cross section of the second marking cavity 220 perpendicular to the axis is a circular ring, and the inner diameter of the circular ring cross section is larger than the maximum outer diameter of the cross section of the first marking cavity 210 perpendicular to the axis, the outer diameter of the circular ring cross section is smaller than the outer diameter of the cross section of the angiography guide wire perpendicular to the axis, the length of the second marking cavity 220 is smaller than the length of the first marking cavity 210, and the first marking cavity 210 and the second marking cavity 220 are respectively encapsulated with T1 contrast agent and T2 contrast agent.

[0037] A vascular guidewire for therapeutic surgery is provided with a first marking cavity and a second marking cavity which are coaxially arranged. The cross-section of the second marking cavity perpendicular to the axis is annular, the outer diameter of the annular cross-section is smaller than the outer diameter of the guidewire, and the inner diameter of the annular cross-section is larger than the outer diameter of the cross-section of the first marking cavity perpendicular to the axis. T1-type contrast agent and T2-type contrast agent are respectively encapsulated in the first marking cavity and the second marking cavity. The T1-type and T2-type contrast agents are respectively coaxially arranged, so that areas with different brightness on the contrast image can distinguish the shape of the blood vessel according to the different brightness, and the shape of the blood vessel can be clearly displayed, thereby ensuring the contrast effect and avoiding the defect that the contrast effect is not obvious due to the diversity of blood vessel shapes during the contrast process.

[0038] The first marking cavity and the second marking cavity are respectively provided with a replenishing port, and the replenishing port is used to load contrast agent, and contrast agents of different concentrations can be loaded.

[0039] T1 contrast agents mainly enhance the T1 relaxation time of tissues in MRI, making the image brighter. When T1 contrast agents flow through blood vessels, the signal generated by blood flow contrasts sharply with the surrounding tissues, thus clearly showing the vascular structure. T2 contrast agents mainly affect the T2 relaxation time of tissues and may produce a different brightness effect or contrast than T1 contrast agents. When T2 contrast agents exist in the same axis as T1 contrast agents but in different spaces, they produce different brightness areas on MRI images, which further enhances the recognition of blood vessel shapes, making the contrast effect clearer.

[0040] The diameter size of angiography guidewire is 0.25-0.89mm, and the length size is 110-350cm. Angiography guidewire includes a tube body segment and a head segment. The length size of the head segment is 30-40cm. The diameter size range of angiography guidewire is wide, which can adapt to different sizes and types of blood vessels. Thinner guidewires can pass through small blood vessels more easily, while thicker guidewires can maintain stability and flow in larger blood vessels. As the main part of the guidewire, the tube body segment plays the role of guiding the guidewire into the blood vessel and traveling along the blood vessel. It has a certain degree of flexibility and toughness, and can adapt to the bends and branches of the blood vessels, ensuring that the guidewire can smoothly reach the target blood vessel area. The tube body segment also provides the necessary support for the guidewire to prevent the guidewire from excessively bending or folding in the blood vessel, affecting the delivery of contrast agent and the clarity of the image. The shape and size of the head segment are usually customized according to the morphology and position of the blood vessel. This design enables the head segment to better adapt to the bends and branches of the blood vessels, reducing damage and friction to the blood vessel wall.

[0041] The tube body section includes an inner layer and an outer layer, and the inner layer and the outer layer are fixedly connected. The outer layer is made of PTFE and a hydrophilic material, and the hydrophilic material is one of zirconium oxide, polyvinyl alcohol and polyethylene glycol. The hydrophilic material has good lubricity, which can reduce the friction resistance of the guidewire in the blood vessel, making it easier for the guidewire to pass through the curved and narrow areas of the blood vessel. It helps to reduce the pain and discomfort of the patient and reduce the difficulty and risk during the guidewire operation. PTFE is a high-strength, corrosion-resistant material that can provide the necessary support and stability for the guidewire. After being combined with the hydrophilic material, the overall strength of the guidewire is further improved, and it can better adapt to various complex vascular environments. The combination of PTFE and hydrophilic materials can enhance the wear resistance of the guidewire, making the guidewire more durable during use. This helps to extend the service life of the guidewire, has good anti-aging properties, and can resist oxidation and degradation during long-term use. PTFE has good biocompatibility and can reduce the possibility of interaction between the guidewire and physiological fluids or drugs. Hydrophilic materials such as zirconium oxide, polyvinyl alcohol, and polyethylene glycol can provide additional lubricity, further reducing friction of the guidewire within the vessel and improving push performance.

[0042] The material components of the inner layer include: PTFE, TPU and Wu. TPU is a thermoplastic elastomer with good elasticity and biocompatibility. It can provide better flexibility and durability, while ensuring the compatibility of the guidewire with vascular tissue, reducing inflammatory reactions and rejection reactions. Wu is part of the inner layer of the guidewire, and it may help to further enhance the lubricity and biocompatibility of the guidewire. The lubricity and stability of the inner layer of the guidewire help reduce artifacts and interference during angiography. This can improve imaging effects and improve the accuracy and reliability of diagnosis. Wu has high density, high melting point and good X-ray attenuation properties, and may be used to improve the X-ray visibility of the guidewire,

[0043] The components of T1 contrast agent are: TPU, enhancer and BiSO4, wherein the enhancer contains Wu and the mass proportion of WU is greater than or equal to 40%. Wu has a high relaxation efficiency due to its high atomic number, which can significantly shorten the T1 relaxation time, enhance the signal of MRI images, make the image brighter, and thus improve the contrast and clarity of imaging. As a heavy metal, tungsten's high density characteristics may help reduce the total dose required for contrast agents while maintaining or improving the imaging effect, which may help reduce the total radiation dose received by patients. The addition of TPU can improve the stability of contrast agents and improve the sustained effect of imaging. The use of BiSO4 can improve the resolution of MRI images, especially when displaying organs and diseased tissues with different water content in tissues, by increasing the relaxation rate of water protons in local tissues, improving the imaging contrast between normal tissues and diseased areas, and enhancing the image brightness of T1 contrast agents.

[0044] The ingredients in T2 contrast agents are superparamagnetic ferroferric oxide particles in liquid, with a concentration of 5-10mg / ml. As the main component of T2 contrast agents, superparamagnetic ferroferric oxide particles have the ability to shorten the transverse relaxation time of protons. When these particles enter the human body, they will cause local magnetic field inhomogeneity, thereby reducing the T2 signal and making the diseased tissue appear low-brightness in MRI, thereby enhancing image contrast.

[0045] There is an overlapping portion between the first marking cavity 210 and the second marking cavity 220 along the axial direction, and the length dimension of the second marking cavity 220 is greater than the length dimension of the overlapping portion. When the two marking cavities partially overlap, a clear reference point can be provided to more accurately determine the position and direction of the guide wire. When the first marking cavity 210 and the second marking cavity 220 are accurately aligned, the closed figure formed by them on the projection can be used to quickly feedback whether the alignment is accurate. This design can be binarized or image size recognized by an image recognition machine to confirm the area of ​​the closed figure, thereby identifying the accuracy of the alignment. During the alignment process, if the center of the mark is offset, this design can reduce the risk of incorrect alignment. Due to the different shapes and positions of the two marking cavities, the position of the offset part can be accurately distinguished, which is convenient for adjustment.

[0046] In the process of inserting the guidewire deeper, there are three situations in the projection along the axis, namely, the second marker cavity 220, the first marker cavity 210, the second marker cavity 220, and the first marker cavity 210. The blood vessels can be angiographically imaged according to different situations, so that a more comprehensive image can be formed, and the quality of angiography is guaranteed. By setting different marker cavities, the depth of the guidewire in the body can be accurately indicated. Each marker cavity corresponds to a specific depth, so that the position of the guidewire can be accurately determined. When only the second marker cavity is visible, it may mean that the guidewire has not reached the target area; when both marker cavities are visible, it may mean that the guidewire has approached the target area but has not yet arrived; when only the first marker cavity is visible, it may mean that the guidewire has reached or exceeded the target area. Such a design helps to avoid the guidewire being inserted too deep or too shallow, thereby enhancing the safety and reliability of the operation.

[0047] The mass ratio between the T1 contrast agent encapsulated in the first marking cavity 210 and the T2 contrast agent encapsulated in the second marking cavity 220 is 6-10:1. The T1 contrast agent will make the relevant part brighter during imaging, while the T2 contrast agent will make the imaging part darker. By adjusting the mass ratio of the two, the imaging effect can be optimized, making the contrast between T1-weighted imaging and T2-weighted imaging more obvious.

[0048] The radial dimensions of the first marking cavity 210 and the second marking cavity 220 along the axial direction remain unchanged. The marking cavities with unchanged radial dimensions present clear and consistent shapes in MRI images. Embodiment 1

[0049] like Figure 2 As shown, a vascular guidewire for treatment surgery includes: a guidewire base 100, and a marking cavity 200 arranged on the guidewire base 100:

[0050] The marking cavity 200 includes: a first marking cavity 210, and a second marking cavity 220 coaxially arranged with the first marking cavity 210, the outer contour of the cross section of the angiography guide wire perpendicular to the axis is circular, the first marking cavity 210 coincides with the axis of the angiography guide wire, and the axis of the first marking cavity 210 passes through the centroid of the outer contour of the first marking cavity 210 in the cross section perpendicular to the axis of the first marking cavity 210;

[0051] The cross section of the second marking cavity 220 perpendicular to the axis is a circular ring, and the inner diameter of the circular ring cross section is larger than the maximum outer diameter of the cross section of the first marking cavity 210 perpendicular to the axis, the outer diameter of the circular ring cross section is smaller than the outer diameter of the cross section of the angiography guide wire perpendicular to the axis, the length of the second marking cavity 220 is smaller than the length of the first marking cavity 210, and the first marking cavity 210 and the second marking cavity 220 are respectively encapsulated with T1 contrast agent and T2 contrast agent.

[0052] The diameter of the angiography guidewire is 0.25 mm and the length is 110 cm. The angiography guidewire includes a body section and a head section, and the length of the head section is 30 cm.

[0053] The tube body section includes an inner layer and an outer layer, the inner layer and the outer layer are fixedly connected, the outer layer is made of PTFE and a hydrophilic material, and the hydrophilic material is zirconium oxide. The material components of the inner layer include: PTFE, TPU and Wu.

[0054] The components of T1 contrast agent are: TPU, Wu and BiSO4, of which Wu accounts for 40% or more by mass. The components of T2 contrast agent are superparamagnetic ferroferric oxide particle liquid with a concentration of 5-10mg / ml.

[0055] There is an overlapping portion between the first marking cavity 210 and the second marking cavity 220 along the axial direction, and the length dimension of the second marking cavity 220 is greater than the length dimension of the overlapping portion.

[0056] The cross-sectional shape of the first marking cavity 210 can be an equilateral triangle, and the side length of the cross-sectional shape of the equilateral triangle is half of the inner ring radius of the second marking cavity 220 .

[0057] The mass ratio between the T1 contrast agent encapsulated in the first marking cavity 210 and the T2 contrast agent encapsulated in the second marking cavity 220 is 6: 1. The radial dimensions of the first marking cavity 210 and the second marking cavity 220 along the axial direction are respectively constant. Embodiment 2

[0058] like Figure 3 As shown, a vascular guidewire for treatment surgery includes: a guidewire base 100, and a marking cavity 200 arranged on the guidewire base 100:

[0059] The marking cavity 200 includes: a first marking cavity 210, and a second marking cavity 220 coaxially arranged with the first marking cavity 210, the outer contour of the cross section of the angiography guide wire perpendicular to the axis is circular, the first marking cavity 210 coincides with the axis of the angiography guide wire, and the axis of the first marking cavity 210 passes through the centroid of the outer contour of the first marking cavity 210 in the cross section perpendicular to the axis of the first marking cavity 210;

[0060] The cross section of the second marking cavity 220 perpendicular to the axis is a circular ring, and the inner diameter of the circular ring cross section is larger than the maximum outer diameter of the cross section of the first marking cavity 210 perpendicular to the axis, the outer diameter of the circular ring cross section is smaller than the outer diameter of the cross section of the angiography guide wire perpendicular to the axis, the length of the second marking cavity 220 is smaller than the length of the first marking cavity 210, and the first marking cavity 210 and the second marking cavity 220 are respectively encapsulated with T1 contrast agent and T2 contrast agent.

[0061] The diameter of the angiography guidewire is 0.89 mm and the length is 350 cm. The angiography guidewire includes a body section and a head section, and the length of the head section is 40 cm.

[0062] The pipe body section includes an inner layer and an outer layer, the inner layer and the outer layer are fixedly connected, the outer layer is made of PTFE and a hydrophilic material, and the hydrophilic material is polyvinyl alcohol. The material components of the inner layer include: PTFE, TPU and Wu.

[0063] The components of T1 contrast agent are: TPU, Wu and BiSO4, of which Wu accounts for 40% or more by mass. The components of T2 contrast agent are superparamagnetic ferroferric oxide particle liquid with a concentration of 5-10mg / ml.

[0064] There is an overlapping portion between the first marking cavity 210 and the second marking cavity 220 along the axial direction, and the length dimension of the second marking cavity 220 is greater than the length dimension of the overlapping portion.

[0065] The cross-sectional shape of the first marking cavity 210 can be an ellipse. In the ellipse cross-sectional shape, the minor axis size is half of the inner ring radius size of the second marking cavity 220, and the minor axis ratio to the major axis ratio is 1:1.5.

[0066] The mass ratio between the T1 contrast agent encapsulated in the first marking cavity 210 and the T2 contrast agent encapsulated in the second marking cavity 220 is 10: 1. The radial dimensions of the first marking cavity 210 and the second marking cavity 220 along the axial direction are respectively constant. Embodiment 3

[0067] like Figure 4 As shown, a vascular guidewire for treatment surgery includes: a guidewire base 100, and a marking cavity 200 arranged on the guidewire base 100:

[0068] The marking cavity 200 includes: a first marking cavity 210, and a second marking cavity 220 coaxially arranged with the first marking cavity 210, the outer contour of the cross section of the angiography guide wire perpendicular to the axis is circular, the first marking cavity 210 coincides with the axis of the angiography guide wire, and the axis of the first marking cavity 210 passes through the centroid of the outer contour of the first marking cavity 210 in the cross section perpendicular to the axis of the first marking cavity 210;

[0069] The cross section of the second marking cavity 220 perpendicular to the axis is a circular ring, and the inner diameter of the circular ring cross section is larger than the maximum outer diameter of the cross section of the first marking cavity 210 perpendicular to the axis, the outer diameter of the circular ring cross section is smaller than the outer diameter of the cross section of the angiography guide wire perpendicular to the axis, the length of the second marking cavity 220 is smaller than the length of the first marking cavity 210, and the first marking cavity 210 and the second marking cavity 220 are respectively encapsulated with T1 contrast agent and T2 contrast agent.

[0070] The diameter of the angiography guidewire is 0.51 mm and the length is 230 cm. The angiography guidewire includes a tube body section and a head section. The length of the head section is 35 cm. The tube body section includes an inner layer and an outer layer. The inner layer and the outer layer are fixedly connected. The outer layer is made of PTFE and a hydrophilic material. The hydrophilic material is polyethylene glycol. The material components of the inner layer include: PTFE, TPU and Wu.

[0071] The components of T1 contrast agent are: TPU, Wu and BiSO4, of which Wu accounts for 40% or more by mass. The components of T2 contrast agent are superparamagnetic ferroferric oxide particle liquid with a concentration of 5-10mg / ml.

[0072] There is an overlapping portion between the first marking cavity 210 and the second marking cavity 220 along the axial direction, and the length dimension of the second marking cavity 220 is greater than the length dimension of the overlapping portion.

[0073] The cross-sectional shape of the first marking cavity 210 can be a square, and the side length of the square cross-sectional shape is half of the inner ring radius of the second marking cavity 220 .

[0074] The mass ratio between the T1 contrast agent encapsulated in the first marking cavity 210 and the T2 contrast agent encapsulated in the second marking cavity 220 is 8: 1. The radial dimensions of the first marking cavity 210 and the second marking cavity 220 along the axial direction are respectively constant.

[0075] When the present invention is used, the angiography guide wire is placed in a predetermined position. During the process of advancing the guide wire, there are three situations in the projection along the axis, namely, the second marking cavity 220 exists alone, the first marking cavity 210 and the second marking cavity 220 exist alone, and the first marking cavity 210 exists alone. The angiography images formed by these three situations are recorded respectively. When abnormalities are found in the images in the second marking cavity 220 exists alone and the first marking cavity 210 exists alone, the overlapping part of the first marking cavity 210 and the second marking cavity 220 is placed in the abnormal area, and the angiography guide wire is rotated. When the difference between the images displayed in the first marking cavity 210 and the second marking cavity 220 is too large, it is recorded.

[0076] Different regions within the blood vessel can be clearly observed by separately recording the angiographic images of the second marking cavity 220 and the first marking cavity 210. When an abnormal image is found, the overlapped portion of the first marking cavity 210 and the second marking cavity 220 is placed in the abnormal region to further accurately locate the lesion.

[0077] Comparative Example 1

[0078] A vascular guidewire for treatment surgery comprises: a guidewire base, and a marking cavity arranged on the guidewire base, wherein the marking cavity coincides with the axis of the guidewire, and the cross-sectional shape of the marking cavity is circular. The contrast agent in the marking cavity is a T1 type contrast agent, and the components of the T1 type contrast agent are TPU, Wu and BiSO 4， The diameter of the angiography guidewire is 0.51 mm and the length is 230 cm. The angiography guidewire includes a body section and a head section, and the length of the head section is 35 cm.

[0079] An MRI scan of a blood vessel is performed using the guidewires in Examples 1 to 3, and images containing bright rings and dark rings are collected. Image processing software is used to measure the edge sharpness of the bright rings and the dark rings to evaluate their clarity, and an area between the bright rings and the dark rings is selected to measure the difference in signal intensity. The contrast is defined as the ratio of the signal intensities of the two areas. The clarity data and contrast data of the bright and dark rings are shown in Table 1. The sharpness of the bright ring in Comparative Example 1 refers to the highlighted area during the angiography process.

[0080] Table 1: Clarity and contrast data of bright and dark rings of Examples 1 to 3 and Comparative Example 1

[0081]

[0082] It can be seen from Table 1 that the sharpness of the bright rings in Examples 1 to 3 is greater than that in Comparative Example 1, and the contrast effects in Examples 1 to 3 are better than that in the Comparative Example.

[0083] Among Examples 1 to 3, the bright ring sharpness, dark ring sharpness and bright and dark ring contrast of Example 2 are all greater than those of Example 1 and Example 3, and Example 2 is the most preferred.

[0084] The above is based on the ideal embodiment of the present invention. Through the above description, relevant personnel can make various changes and modifications without departing from the technical concept of the present invention. The technical scope of the present invention is not limited to the content in the specification, and the technical scope must be determined according to the scope of the claims.

Claims

1. A vascular guidewire for therapeutic surgery, comprising: A guidewire substrate (100), and a marking cavity (200) arranged on the guidewire substrate (100), characterized in that: The marking cavity (200) comprises: a first marking cavity (210), and a second marking cavity (220) coaxially arranged with the first marking cavity (210); the outer contour of the cross section of the vascular guide wire perpendicular to the axis is circular; the first marking cavity (210) coincides with the axis of the vascular guide wire; the axis of the first marking cavity (210) passes through the centroid of the outer contour of the cross section of the first marking cavity (210) perpendicular to the axis of the first marking cavity (210); The cross section of the second marking cavity (220) perpendicular to the axis is a circular ring, and the inner diameter of the circular ring cross section of the second marking cavity (220) is greater than the maximum outer diameter of the cross section of the first marking cavity (210) perpendicular to the axis, the outer diameter of the circular ring cross section of the second marking cavity (220) is smaller than the outer diameter of the cross section of the vascular guide wire perpendicular to the axis, the length of the second marking cavity (220) is smaller than the length of the first marking cavity (210), and the first marking cavity (210) and the second marking cavity (220) are respectively encapsulated with a T1 contrast agent and a T2 contrast agent; The components of the T1 type contrast agent are: TPU, an enhancer and BiSO4, the enhancer contains Wu and the mass proportion of Wu is greater than or equal to 40%, the component of the T2 type contrast agent is a superparamagnetic ferroferric oxide particle solution with a concentration of 5-10 mg / ml, the first marking cavity (210) and the second marking cavity (220) have an overlapping portion along the axial direction, and the length dimension of the second marking cavity (220) is greater than the length dimension of the overlapping portion.

2. A vascular guidewire for therapeutic surgery according to claim 1, characterized in that: The diameter of the vascular guidewire is 0.25-0.89 mm, and the length is 110-350 cm. The vascular guidewire comprises a tube body section and a head section, and the length of the head section is 30-40 cm.

3. A vascular guidewire for therapeutic surgery according to claim 2, characterized in that: The pipe body section comprises an inner layer and an outer layer, the inner layer and the outer layer are fixedly connected, the outer layer is made of PTFE and a hydrophilic material, and the hydrophilic material is one of zirconium oxide, polyvinyl alcohol and polyethylene glycol.

4. A vascular guidewire for therapeutic surgery according to claim 3, characterized in that: The material components of the inner layer include: PTFE, TPU and Wu.

5. A vascular guidewire for therapeutic surgery according to claim 1, characterized in that: The cross-sectional shape of the first marking cavity (210) can be one of an equilateral triangle, an ellipse and a square.

6. A vascular guidewire for therapeutic surgery according to claim 1, characterized in that: The mass ratio between the T1-type contrast agent encapsulated in the first marking cavity (210) and the T2-type contrast agent encapsulated in the second marking cavity (220) is 6-10:

1.

7. A vascular guidewire for therapeutic surgery according to claim 1, characterized in that: The radial dimensions of the first marking cavity (210) and the second marking cavity (220) along the axial direction are respectively unchanged.

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