A detection device and method for detecting additives of Chinese patent medicine

Abstract

The present invention relates to the technical field of testing or analyzing materials by means of determining the chemical or physical properties of the materials, and specifically to a detection device and a detection method for additive components of Chinese patent medicines. The detection device for additive components of Chinese patent medicines comprises a mass spectrometer body, a cavity is arranged on one side of the mass spectrometer body; a tray and a target plate are arranged in the cavity, and a plurality of grooves are arranged on the target plate; the tray is rotatably connected to the cavity through a pin shaft, and a first driving mechanism for driving the rotation of the pin shaft is connected to the pin shaft in a transmission manner; a clamping mechanism is arranged on the other side of the mass spectrometer body, and the clamping mechanism forms a hold on a container, and the container is used to place an initial sample to be tested; a second driving mechanism is connected to the clamping mechanism in a transmission manner, and the second driving mechanism is used to drive the clamping mechanism to approach or move away from a probe of the mass spectrometer body; the present invention also includes a detection method using the detection device for additive components of Chinese patent medicines; the present invention solves the problem of how to clamp a container containing a sample of Chinese patent medicine components.

Description

Technical Field

[0001] The present invention relates to the technical field of testing or analyzing materials by means of determining the chemical or physical properties of materials, and in particular to a detection device and method for detecting additive components of traditional Chinese medicines. Background Art

[0002] Drug component detection is an important part of drug analysis, which aims to study the composition, physical and chemical properties, authenticity identification, purity inspection and determination of the content of active ingredients of drugs and their preparations, so as to ensure that people use drugs safely, reasonably and effectively. Among them, Chinese patent medicine component detection, as a branch of drug detection, can identify various components in Chinese patent medicines, so as to ensure drug safety and quality. The relevant prior art of drug component detection is disclosed in the Chinese patent library; for example, the announcement number CN115902068A discloses a drug component detection method and device, including: constructing a first group of reacted solutions, a second group of reacted solutions and a third group of reacted solutions according to the clinical drugs to be detected and the experimental blood, using liquid chromatography-tandem mass spectrometry to generate diuretic chromatographic data of the first group of reacted solutions, preservative chromatographic data of the second group of reacted solutions and antibiotic chromatographic data of the third group of reacted solutions, and determining the proportion of dangerous drug components of the clinical drugs to be detected according to the diuretic chromatographic data, preservative chromatographic data and antibiotic chromatographic data.

[0003] For another example, announcement number CN219996962U discloses another plant medicinal ingredient extraction sampling and detection device, including a sampling and detection device, the sampling and detection device includes a base, a rubber base, a mass spectrometer, a battery, an electromagnet, a fixed metal table, a placement hole, a test tube, an electric push rod, a processing plate, a high-temperature heating plate and an ultraviolet sterilization lamp, the battery is installed inside the top of the mass spectrometer, the electromagnet is installed on the top of the battery, the fixed metal table is installed on the top of the electromagnet, the electric push rod is installed on the top inside the fixed metal table, the processing plate is installed on the top of the electric push rod, the high-temperature heating plate is installed on the bottom of the processing plate, and the ultraviolet sterilization lamp is installed on the side of the high-temperature heating plate.

[0004] It can be seen from the above two prior arts (CN115902068A, CN219996962U) that the existing problem is that before using a mass spectrometer to detect the ingredients of a Chinese patent medicine, it is necessary to first transfer the container (beaker or test tube) containing the Chinese patent medicine ingredient sample to the bottom of the probe of the mass spectrometer; and during the container transfer process, it is necessary to use a clamp to clamp the container, and the above prior arts do not disclose how to clamp the container containing the Chinese patent medicine ingredient sample. Summary of the invention

[0005] In view of this, the purpose of the present invention is to provide a detection device and method for additives in Chinese patent medicines, so as to solve the problem of how to clamp a container containing samples of Chinese patent medicine ingredients.

[0006] In the first aspect, the present invention discloses a detection device for additives in Chinese patent medicines, wherein a cavity is provided on one side of a mass spectrometer body, and a cabinet door is provided on the cavity; a tray is provided in the cavity, and a target plate is detachably connected to the tray, and more than two grooves are provided on the target plate, and the grooves are used to hold samples to be tested after being processed by the mass spectrometer; the tray is rotatably connected to the cavity through a pin shaft, and a first driving mechanism for driving the pin shaft to rotate is transmission-connected to the pin shaft; a clamping mechanism is provided on the other side of the mass spectrometer body, and the clamping mechanism includes a track frame, which is fixedly connected to the mass spectrometer, and a support seat is slidably connected to the track frame, and both sides of the support seat are respectively slidably connected to the tail ends of the corresponding clamping hoops, and a first elastic component is connected between the clamping hoop and the support seat; the holding parts of the two clamping hoops are arranged opposite to each other and are used to hold the container, and the container is used to place the initial sample to be tested; a second driving mechanism is transmission-connected to a flange on one side of the support seat, and the second driving mechanism is used to drive the support seat to approach or move away from the probe of the mass spectrometer body.

[0007] A first implementation of the first driving mechanism is as follows: the first driving mechanism comprises an electric motor, the electric motor is fixedly connected to the inner wall of the cavity, and the electric output shaft is fixedly connected concentrically with the pin shaft.

[0008] A second implementation of the first driving mechanism is: the first driving mechanism includes a transmission gear, which is concentrically fixedly connected to the pin shaft, and a toothed plate is appropriately provided on the transmission gear, and the other end of the toothed plate slides through the back of the mass spectrometer body and forms a fixed connection with the flange of the support seat; when the container is opposite to the probe, the groove on the target plate opens upward; after the container moves away from the probe and reaches the sample adding station, the groove on the target plate opens downward.

[0009] As a further limitation of the second driving mechanism, the second driving mechanism includes a servo, which is fixedly connected to the support arm, and the support arm is fixedly connected to the track frame; a threaded shaft is concentrically fixedly connected to the output shaft of the servo, and the other end of the threaded shaft is rotationally connected to the mass spectrometer body; a plug plate is threadedly connected to the threaded shaft, and the plug plate is slidably connected to the socket of the mass spectrometer body; the plug plate is connected to the flange of the support seat.

[0010] The present invention after applying the second driving mechanism is further defined as follows: the present invention also includes a cleaning mechanism, the plug plate is connected with the cleaning mechanism, and the cleaning mechanism is used to wash the target plate with the groove opening facing downward.

[0011] Specifically, the cleaning mechanism includes an insert cavity, which is fixedly connected to one side of the cavity of the mass spectrometer body, a channel is formed on the side wall of the insert cavity, and the insert plate passes through the insert hole and is placed in the channel of the insert cavity; a first through hole is formed through the upper and lower ends of the insert plate, and a second through hole is formed through the top and bottom of the insert cavity respectively; when the container is away from the probe and moves to the sample adding station, the first through hole and the second through hole are opposite to each other and a pore is formed; when the container is opposite to the probe, the first through hole and the second through hole are completely misaligned and no pore is formed; one end of the insert cavity is fixedly connected to a baffle plate, and one end of the baffle plate is close to the tray The side is a placement chamber, and the side of the baffle plate close to the insertion chamber is a cleaning chamber; the insertion chamber divides the cleaning chamber into an upper cleaning chamber and a lower cleaning chamber; a guide tube is connected to the second through hole at the bottom of the insertion chamber, and the shower plate is fixedly connected to the placement chamber; the free end of the guide tube passes through the baffle plate and is connected to the shower plate, and the multiple nozzles on the shower plate correspond to the multiple grooves of the target plate respectively; a liquid filling port is provided on the upper cleaning chamber, and the upper cleaning chamber is used to add a cleaning liquid medium. A pump body is provided in the upper cleaning chamber, and the pump body is used to pump the cleaning liquid medium into the guide tube.

[0012] More specifically, an electric stop valve is installed on the liquid injection port.

[0013] In a second aspect, the present invention discloses a detection method, which uses the above-mentioned Chinese patent medicine additive detection device, comprising the following steps:

[0014] S1, when the sample of Chinese patent medicine with added ingredients needs to be tested, the second driving mechanism is used to drive the clamping mechanism and the container to move toward the probe of the mass spectrometer until the container reaches the bottom of the mass spectrometer probe; the first driving mechanism is used to flip the target plate and make the groove face upward, and the cleaning mechanism is in a closed state.

[0015] S2, using a mass spectrometer to absorb the sample to be tested in the container, and dripping the sample to be tested into a plurality of grooves of the target plate, and then using the mass spectrometer to detect the components of the sample to be tested in the grooves.

[0016] S3, after the Chinese patent medicine additive sample is tested, the first driving mechanism is used to drive the clamping mechanism and the container to move in the opposite direction of the mass spectrometer probe, the second driving mechanism flips the target plate and makes the groove face downward, and the cleaning mechanism cleans the target plate and the groove.

[0017] S4, when the container moves toward the end of the track frame, the used container is removed by the clamping mechanism, and a new container containing the sample to be tested is loaded on the clamping mechanism.

[0018] The beneficial effects of the present invention are:

[0019] The present invention can effectively clamp a container containing a sample by designing the track frame, support seat, clamping hoop, first elastic component and other components of the clamping mechanism; compared with the prior art, the present invention solves the problem of how to clamp a container containing a sample of a Chinese patent medicine ingredient. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A schematic diagram of the first-person perspective stereoscopic structure of a device for detecting ingredients added to traditional Chinese medicine.

[0021] Figure 2 A schematic diagram of the stereoscopic structure from a second perspective of a device for detecting ingredients added to traditional Chinese medicine.

[0022] Figure 3 Schematic diagram of the partial structure of the device for detecting ingredients added to traditional Chinese medicine.

[0023] Figure 4 This is a schematic installation diagram from a front side perspective of the second embodiment of the first driving mechanism.

[0024] Figure 5 This is a schematic installation diagram of the second embodiment of the first driving mechanism from a rear side perspective.

[0025] Figure 6 It is a schematic diagram of the installation structure of the second driving mechanism.

[0026] Figure 7 It is a schematic diagram of the assembly structure of the cleaning mechanism.

[0027] Figure 8 It is a schematic diagram of the local structure of the cleaning mechanism.

[0028] Fig. 9 It is a schematic diagram of the three-dimensional structure of the plug board and the plug cavity.

[0029] Fig.10 Schematic diagram of the three-dimensional structure of the optimized clamping mechanism.

[0030] Fig.11 It is a schematic diagram of the three-dimensional structure of the flip seat and the rotating shaft.

[0031] Fig.12 This is the motion state diagram of the clamping mechanism after optimization.

[0032] In the figure, 1, mass spectrometer body; 2, tray; 3, target plate; 4, groove; 5, pin shaft; 6, track frame; 7, support seat; 8, clamping hoop; 9, first elastic component; 10, transmission gear; 11, gear plate; 12, steering gear; 13, support arm; 14, threaded shaft; 15, plug plate; 16, plug hole; 17, plug cavity; 18, channel; 19, first through hole; 20, second through hole; 21, baffle; 22, placement cavity; 23, upper cleaning cavity; 24, lower cleaning cavity; 25, guide tube; 26, shower tray; 27, nozzle; 28, liquid injection port; 29, electric stop valve; 30, wedge block; 31, flip seat; 32, retaining edge; 33, rotating shaft; 34, second elastic component. DETAILED DESCRIPTION

[0033] In order to clearly understand the technical solution of the present application, a detection device and a detection method for additives in Chinese patent medicines provided by the present application will be described in detail below in combination with specific embodiments and drawings.

[0034] The terms used in the following embodiments are only for the purpose of describing specific embodiments, and are not intended to be used as limitations to the present application. As used in the specification and claims of the present application, the singular expressions "one", "a kind of", "above", "the" and "this" are intended to also include expressions such as "one or more", unless there is a clear indication to the contrary in the context. It should also be understood that in the following embodiments of the present application, "at least one", "one or more" refer to one, two or more than two.

[0035] References to "one embodiment" or "some embodiments" etc. described in this specification mean that a particular feature, structure or characteristic described in conjunction with the embodiment is included in one or more embodiments of the present application. Thus, the phrases "one embodiment", "in some embodiments", "in some other embodiments", "in some other embodiments", etc. appearing in different places in this specification do not necessarily all refer to the same embodiment, but mean "one or more but not all embodiments", unless otherwise specifically emphasized in other ways. The terms "including", "comprising", "having" and their variations all mean "including but not limited to", unless otherwise specifically emphasized in other ways.

[0036] Embodiment 1, this embodiment provides a detection device for adding ingredients to a Chinese patent medicine, such as Figure 1-2 ,in, Figure 1 The figure shows a schematic diagram of a three-dimensional structure of a device for detecting additives in Chinese patent medicines from a first perspective. Figure 2What is shown is a schematic diagram of the stereoscopic structure of the device for detecting additives of traditional Chinese medicines from a second perspective. It can be seen from the above two figures that the device for detecting additives of traditional Chinese medicines includes a mass spectrometer body 1. The mass spectrometer body 1 directly selects existing technologies available on the market, for example, a mass spectrometer of model HD-R827 can be used, which will not be repeated here; a cavity is provided on the front side of the mass spectrometer body 1, and a cabinet door is provided at the opening of the cavity; a tray 2 is provided in the cavity, and a target plate 3 is detachably mounted on the tray 2 by a locking mechanism (such as bolts, etc.), and the upper surface of the target plate 3 has a plurality of grooves 4 for holding samples to be tested that need to be detected by matrix-assisted laser desorption-tandem time-of-flight mass spectrometer; a pin 5 is fixedly connected to the bottom protrusion of the tray 2, and both ends of the pin 5 are rotatably connected to the inner wall of the cavity; a first driving mechanism is transmission-connected to the pin 5, and the first driving mechanism is used to drive the pin 5 to rotate. The back of the mass spectrometer body 1 is provided with a clamping mechanism, which specifically includes a track frame 6, which is fixedly connected to the back of the mass spectrometer body 1, and a support seat 7 is slidably connected to the bottom slide of the track frame 6, and a placement portion is formed on the top of the support seat 7; further combined Figure 3 The schematic diagram of the partial structure of the device for detecting additives in proprietary Chinese medicines is shown in the figure, wherein a clamping hoop 8 is respectively provided on one side of the two horizontal arms of the placement portion, and the tail end of the clamping hoop 8 is slidably connected with the adjacent horizontal arm, and the clamping hoop 8 is connected with a first elastic component 9 (such as a spring, etc.), and the other end of the first elastic component 9 is fixedly connected with the adjacent horizontal arm; the holding parts of the two clamping hoops 8 are arranged opposite to each other, and the two clamping hoops 8 are used together to hold the container; a second driving mechanism is transmission-connected to a flange on one side of the support seat 7, and the second driving mechanism is used to drive the support seat 7 to approach or move away from the probe of the mass spectrometer body 1, so that when the support seat 7 is close to the probe, the container is correspondingly placed under the probe, so that the probe can absorb the proprietary Chinese medicine in the container.

[0037] The present invention can effectively clamp a container containing a sample by designing the track frame 6, support seat 7, clamping hoop 8, first elastic component 9 and other components of the clamping mechanism; compared with the prior art, the present invention solves the problem of how to clamp a container containing a sample of a Chinese patent medicine ingredient.

[0038] Specifically, the present invention cites the following two implementations of the first drive mechanism (of course, it is not limited to the following two implementations). The first implementation of the first drive mechanism (this implementation is not shown in the figure) includes an electric motor, the electric motor is fixedly connected to the inner wall of the cavity, and the electric output shaft is fixedly connected concentrically with the pin 5. The second implementation of the first drive mechanism, refer to Figure 4-5 , Figure 4 It shows a front side view installation diagram of the second embodiment of the first driving mechanism. Figure 5What is shown is a schematic installation diagram of the second embodiment of the first driving mechanism from a rear perspective. It can be seen from the above two figures that the first driving mechanism includes a transmission gear 10, which is concentrically fixedly connected to the pin shaft 5. The transmission gear 10 is meshed with a toothed plate 11, and the other end of the toothed plate 11 slides through the back of the mass spectrometer body 1 and forms a fixed connection with the flange of the support seat 7; at the same time, it is stipulated that when the container is opposite to the probe, under the linkage action of the transmission gear 10 and the toothed plate 11, the groove 4 on the target plate 3 opens upward; and when the container is away from the probe and reaches the sample adding station, under the linkage action of the transmission gear 10 and the toothed plate 11, the groove 4 on the target plate 3 opens downward.

[0039] The present invention can flip the tray 2 and the target plate 3 by combining with the first driving mechanism; thus, when the grooves 4 of the target plate 3 are opened upward, the sample to be tested sucked by the mass spectrometer body 1 drops into each groove 4 of the target plate 3, so that the mass spectrometer body 1 can then perform component detection on the sample to be tested; and when the component detection of the sample to be tested is completed, the grooves 4 of the target plate 3 need to be opened downward to facilitate the subsequent cleaning of the grooves 4 on the target plate 3.

[0040] Specifically, refer to Figure 6 , which is a schematic diagram of the installation structure of the second driving mechanism. It can be seen from the figure that the second driving mechanism is fixedly connected to the track frame 6, and the output end of the second driving mechanism is connected to the support seat 7. The structure of the second driving mechanism of the present invention is as follows.

[0041] Continue as Figure 6 As shown in , the second driving mechanism includes a steering gear 12, on the outer wall of which a support arm 13 is fixedly connected by welding, and the support arm 13 is fixedly connected to the track frame 6; a threaded shaft 14 is coaxially fixedly connected to the output shaft of the steering gear 12, and the other end of the threaded shaft 14 is rotatably connected to the back of the mass spectrometer body 1; a plug plate 15 is threadedly connected to the threaded shaft 14, and the plug plate 15 forms a sliding connection with the back plug hole 16 of the mass spectrometer body 1; the plug plate 15 is connected to the flange of the support seat 7. When the second driving mechanism is in use, the steering gear 12 is started to drive the threaded shaft 14 to rotate, and the rotating threaded shaft 14 and the plug hole 16 jointly limit the plug plate 15 and the support seat 7 to move, and finally indirectly make the container close to or away from the probe of the mass spectrometer body 1.

[0042] Optimized, when cleaning the groove 4 of the target plate 3, a cleaning mechanism needs to be used for cleaning operation; for this purpose, the present invention further designs a cleaning mechanism, referring to Figure 7 , which shows a schematic diagram of the assembly structure of the cleaning mechanism. It can be seen from the figure that the cleaning mechanism is connected to the plug plate 15, and the cleaning mechanism is used to rinse the target plate 3 with the groove 4 opening facing downward; the specific structure of the cleaning mechanism is as follows.

[0043] Continue as Figure 7 As shown in the figure, the cleaning mechanism includes an insert cavity 17, which is fixedly connected to one side of the cavity of the mass spectrometer body 1 in a horizontal manner, and a channel 18 is formed through the side wall of the insert cavity 17. The insert plate 15 passes through the insert hole 16 and is placed in the channel 18 of the insert cavity 17; a first through hole 19 is formed at the upper and lower ends of the insert plate 15, and a second through hole 20 is formed at the top and bottom of the insert cavity 17 respectively; at the same time, it is defined that when the container is away from the probe and reaches the sample adding station, the first through hole 19 and the second through hole 20 are The through holes 20 are opposite to each other and form a gap; when the container and the probe are opposite to each other, the first through hole 19 and the second through hole 20 are completely misaligned and no gap is formed; a baffle 21 is fixedly connected to one end of the insertion cavity 17, and the baffle 21 divides the cavity into two, one side of the tray 2 is a placement cavity 22, and the other side of the insertion cavity 17 is a cleaning cavity; the insertion cavity 17 further divides the cleaning cavity into an upper cleaning cavity 23 and a lower cleaning cavity 24; the second through hole 20 at the bottom of the insertion cavity 17 is connected to a guide tube 25, further combined with Figure 8 The schematic diagram of the partial structure of the cleaning mechanism shown in the figure shows that the cleaning mechanism also includes a shower tray 26, which is fixedly connected to the bottom of the placement cavity 22; the free end of the guide tube 25 passes through the baffle 21 and is connected to the shower tray 26, and the multiple nozzles 27 on the shower tray 26 respectively correspond to the multiple grooves 4 of the target plate 3; a liquid injection port 28 is formed on the top of the upper cleaning cavity 23, and an electric stop valve 29 is installed on the liquid injection port 28 (directly using the existing technology, no longer repeated here), and the upper cleaning cavity 23 is filled with a cleaning liquid medium through the liquid injection port 28, and a pump body is installed in the upper cleaning cavity 23, and the pump body is used to pump the cleaning liquid medium into the guide tube 25. Among them, Fig. 9 What is shown is a three-dimensional structural schematic diagram of the plug board 15 and the plug cavity 17.

[0044] The working principle of the cleaning mechanism is as follows: in the first case, first, when the container containing the sample to be tested gradually moves toward the probe direction of the mass spectrometer body 1, the support seat 7 correspondingly drives the plug plate 15 to gradually insert into the insertion cavity 17, and at this time, the first through hole 19 gradually becomes misaligned with the second through hole 20 until the gap between the first through hole 19 and the second through hole 20 disappears; at the same time, once the first through hole 19 and the second through hole 20 are misaligned and the plug plate 15 blocks the first through hole 19, the target plate 3 has been flipped to a state where the groove 4 opens upward, and the probe of the mass spectrometer body 1 is opposite to the opening of the container; then, the probe of the mass spectrometer body 1 is used to absorb the sample to be tested in the container, and then the sample to be tested is dripped into the grooves 4 of the target plate 3 after preliminary treatment by the mass spectrometer body 1, and then the mass spectrometer body 1 is used to perform sample detection processing. In the second situation, first, when the container gradually moves away from the probe of the mass spectrometer body 1, the support seat 7 correspondingly drives the plug plate 15 to be gradually withdrawn from the plug cavity 17 until the first through hole 19 is completely opposite to the second through hole 20; at this time, the target plate 3 has been flipped to a state where the groove 4 opens downward, and the cleaning liquid medium in the upper cleaning cavity 23 flows through the guide tube 25 and the shower plate 26 in sequence under the action of the pump body and is sprayed out from the nozzle 27, and the sprayed cleaning liquid medium performs a single cleaning operation on the target plate 3 and the groove 4.

[0045] When the container moves away from the probe, the sample to be tested in the container has been completely absorbed by the probe; at this time, the used container needs to be removed in time so that a new container containing other samples to be tested can be clamped between the two clamping hoops 8; the present invention further optimizes the clamping mechanism, and the specific structure is as follows.

[0046] refer to Fig.10 , which is a schematic diagram of the three-dimensional structure of the optimized clamping mechanism. It can be seen from the figure that the clamping mechanism also includes a wedge block 30, a single wedge block 30 is fixedly connected to the tail end of the adjacent clamping hoop 8, and the slope surface of the wedge block 30 faces the end side of the track frame 6; a flip seat 31 (which can be combined with a flip seat 31) is rotatably connected to one side of the wedge block 30 and the track frame 6 through a rotating shaft 33. Fig.11 ), a blocking edge 32 is formed on the top seat surface of the flip seat 31; a second elastic component 34 (such as a spring, etc.) is sleeved on the rotating shaft 33, and the other end of the second elastic component 34 is fixedly connected to the adjacent wall surface of the track frame 6; at the same time, it is defined that when the second elastic component 34 is in a natural state, the side wall of the flip seat 31 and the blocking block on the track frame 6 form a close fit, and the slope surface of the wedge-shaped block 30 is opposite to the blocking edge 32 of the flip seat 31 and can form a contact fit.

[0047] The working principle of the optimized clamping mechanism is as follows: First, under the clamping of the clamping hoop 8 and the driving action of the second driving mechanism, the used container moves along the direction a1 toward the end of the track frame 6 (i.e., moves away from the probe of the mass spectrometer body 1); Fig.12 , which shows the motion state diagram of the optimized clamping mechanism. It can be seen from the figure that as the clamping hoop 8 moves, the wedge block 30 gradually contacts the blocking edge 32 of the adjacent flip seat 31. Since the flip seat 31 is blocked by the blocking block, the wedge blocks 30 on both sides will move outward along the b1 or b2 direction respectively until the slope surface of the wedge block 30 slides over the blocking edge 32 of the flip seat 31; at the same time, when the wedge block 30 moves outward, it drives the clamping hoop 8 away from the outer wall of the container accordingly. Then, the container is separated from between the two clamping hoops 8 and falls into the collection frame placed below (the collection frame is provided with an anti-shatter pad); finally, when the two inner clamping hoops 8 re-clamp the new container containing the sample to be tested, as shown in FIG. Fig.10 As shown in the figure, the clamping hoop 8 and the container move toward the mass spectrometer probe (along the a2 direction) under the action of the second driving mechanism. Once the back smooth surface of the wedge block contacts the retaining edge 32 of the flip seat 31, as the wedge block continues to move, the flip seat 31 flips along the c1 direction until the wedge block successfully passes over the flip seat 31.

[0048] Embodiment 2: This embodiment provides a detection method, and the specific steps are as follows:

[0049] Step 1: When the sample of Chinese patent medicine with added ingredients needs to be tested, the second driving mechanism is used to drive the clamping mechanism and the container to move toward the probe of the mass spectrometer until the container reaches the bottom of the mass spectrometer probe; at the same time, the first driving mechanism is used to flip the target plate 3 and make the groove 4 face upward, and the cleaning mechanism is in a closed state at this time.

[0050] Step 2, use a mass spectrometer to absorb the sample to be tested in the container, and drip the sample to be tested into multiple grooves 4 of the target plate 3. The existing working principle of the mass spectrometer is not repeated here. Next, the mass spectrometer is used to detect the components of the sample to be tested in the groove 4.

[0051] Step 3, after the test of the sample of the Chinese patent medicine added ingredients is completed, the first driving mechanism is used to drive the clamping mechanism and the container to move in the opposite direction of the mass spectrometer probe, and the second driving mechanism flips the target plate 3 and makes the groove 4 face downward. At this time, the cleaning mechanism cleans the target plate 3 and the groove 4.

[0052] Step 4: When the container moves toward the end of the track frame, the used container is removed by the clamping mechanism, and a new container containing the sample to be tested is loaded on the clamping mechanism.

Claims

1. A detection device for additives in Chinese patent medicines, characterized in that: The mass spectrometer comprises a mass spectrometer body (1), wherein a cavity is provided on one side of the mass spectrometer body (1), and a cabinet door is provided on the cavity; a tray (2) is provided in the cavity, and a target plate (3) is detachably connected to the tray (2), and the target plate (3) is provided with two or more grooves (4), and the grooves (4) are used to hold samples to be tested after being processed by the mass spectrometer; the tray (2) is rotatably connected to the cavity via a pin shaft (5), and a first driving mechanism for driving the pin shaft (5) to rotate is transmission-connected to the pin shaft (5); a clamping mechanism is provided on the other side of the mass spectrometer body (1), and the clamping mechanism comprises a track frame (6) The track frame (6) is fixedly connected to the mass spectrometer, the track frame (6) is slidably connected to the support seat (7), the two sides of the support seat (7) are respectively slidably connected to the tail ends of the corresponding clamping hoops (8), and the first elastic component (9) is connected between the clamping hoops (8) and the support seat (7); the holding parts of the two clamping hoops (8) are arranged opposite to each other and are used to hold a container, and the container is used to place an initial sample to be tested; a second driving mechanism is drivingly connected to a flange on one side of the support seat (7), and the second driving mechanism is used to drive the support seat (7) to move closer to or away from the probe of the mass spectrometer body (1).

2. The Chinese patent medicine additive detection device according to claim 1, characterized in that: The first driving mechanism comprises an electric motor, the electric motor is fixedly connected to the inner wall of the cavity, and the electric output shaft is concentrically fixedly connected to the pin shaft (5).

3. The Chinese patent medicine additive detection device according to claim 1, characterized in that: The first driving mechanism comprises a transmission gear (10), the transmission gear (10) is coaxially fixedly connected to the pin shaft (5), and a toothed plate (11) is meshed on the transmission gear (10), and the other end of the toothed plate (11) slides through the back of the mass spectrometer body (1) and forms a fixed connection with the flange of the support seat (7); when the container is opposite to the probe, the groove (4) on the target plate (3) opens upward; after the container moves away from the probe and reaches the sample adding station, the groove (4) on the target plate (3) opens downward.

4. The Chinese patent medicine additive detection device according to claim 1, characterized in that: The second driving mechanism comprises a steering gear (12), the steering gear (12) being fixedly connected to a supporting arm (13), and the supporting arm (13) being fixedly connected to a track frame (6); a threaded shaft (14) being coaxially fixedly connected to an output shaft of the steering gear (12), and the other end of the threaded shaft (14) being rotationally connected to a mass spectrometer body (1); a plug plate (15) being threadedly connected to the threaded shaft (14), and the plug plate (15) being slidably connected to a plug hole (16) of the mass spectrometer body (1); and the plug plate (15) being connected to a flange of a support seat (7).

5. The Chinese patent medicine additive detection device according to claim 4, characterized in that: It also includes a cleaning mechanism, the insert plate (15) is connected to the cleaning mechanism, and the cleaning mechanism is used to rinse the target plate (3) with the groove (4) opening facing downward.

6. The Chinese patent medicine additive detection device according to claim 5, characterized in that: The cleaning mechanism comprises an inserting cavity (17), the inserting cavity (17) is fixedly connected to one side of the cavity of the mass spectrometer body (1), a channel (18) is formed on the side wall of the inserting cavity (17), the inserting plate (15) passes through the inserting hole (16) and is placed in the channel (18) of the inserting cavity (17); a first through hole (19) is formed at the upper and lower ends of the inserting plate (15), and a second through hole (20) is formed at the top and bottom of the inserting cavity (17); when the container is away from the probe and moves to the sample adding station, the first through hole (19) and the second through hole (20) are opposite to each other and form a pore; when the container and the probe are opposite to each other, the first through hole (19) and the second through hole (20) are completely misaligned and no pore is formed; one end of the inserting cavity (17) is fixedly connected to a baffle (21), and the side of the baffle (21) close to the tray (2) is for placing the cavity (22), a side of the baffle (21) close to the insertion chamber (17) is a cleaning chamber; the insertion chamber (17) divides the cleaning chamber into an upper cleaning chamber (23) and a lower cleaning chamber (24); a second through hole (20) at the bottom of the insertion chamber (17) is connected to a guide tube (25), and a shower plate (26) is fixedly connected to the placement chamber (22); a free end of the guide tube (25) passes through the baffle (21) and is connected to the shower plate (26), and a plurality of nozzles (27) on the shower plate (26) respectively form a one-to-one correspondence with a plurality of grooves (4) of the target plate (3); a liquid injection port (28) is provided on the upper cleaning chamber (23), and the upper cleaning chamber (23) is used to inject a cleaning liquid medium; a pump body is provided in the upper cleaning chamber (23), and the pump body is used to pump the cleaning liquid medium into the guide tube (25).

7. The Chinese patent medicine additive detection device according to claim 6, characterized in that: An electric stop valve (29) is installed on the liquid injection port (28).

8. A detection method, characterized in that: The use of the Chinese patent medicine additive detection device according to claim 7 comprises the following steps: S1, when a sample of a Chinese patent medicine with an added ingredient needs to be tested, the second driving mechanism is used to drive the clamping mechanism and the container to move toward the probe of the mass spectrometer until the container reaches below the probe of the mass spectrometer; the first driving mechanism is used to flip the target plate (3) and make the groove (4) face upward, and the cleaning mechanism is in a closed state; S2, using a mass spectrometer to absorb the sample to be tested in the container, and dripping the sample to be tested into a plurality of grooves (4) of the target plate (3), and then using the mass spectrometer to detect the components of the sample to be tested in the grooves (4); S3, after the Chinese patent medicine additive sample is tested, the first driving mechanism drives the clamping mechanism and the container to move in the opposite direction of the mass spectrometer probe, the second driving mechanism turns the target plate (3) over and makes the groove (4) face downward, and the cleaning mechanism cleans the target plate (3) and the groove (4); S4, when the container moves toward the end of the track frame, the used container is removed by the clamping mechanism, and a new container containing the sample to be tested is loaded on the clamping mechanism.

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