The clamp for intelligent mechanical design comprises a box body, the upper surface of the box body is slidably connected with two moving blocks, one side of each moving block penetrates through and extends into the box body, a driving mechanism is arranged on the inner bottom wall of the box body, and an adaptive mechanism is arranged on the upper surface of each moving block. According to the clamp for intelligent mechanical design, the adaptive mechanism and the driving mechanism are arranged, through mutual cooperation of all structures of the adaptive mechanism and the driving mechanism, the clamp can clamp mechanical workpieces in different shapes, meanwhile, the clamping effect is good, clamping is more stable, the problem that only mechanical workpieces in regular shapes can be clamped is solved, and the clamping efficiency is improved. And meanwhile, when the mechanical workpiece needs to be designed, the mechanical workpiece can be rotated, so that the design of the mechanical workpiece is more convenient, and when the clamping design is carried out on the larger mechanical workpiece, the distance between the mechanical workpiece and the box body can be adjusted, so that the mechanical workpiece can normally rotate, and good power can be provided for the clamp.