Implants with intracapsular and intracapsular portions and related techniques

Abstract

An implant according to embodiments of the present technology is configured for treating an aneurysm at a treatment location within the vasculature of a patient at which a first blood vessel, a second blood vessel, and a third blood vessel converge. The implant includes an elongate body configured to deploy partially within the first blood vessel, partially within the second blood vessel, and partially within an intermediate portion of the vasculature proximate the aneurysm. The implant also includes a spherical body configured to deploy within the aneurysm. The spherical body is connected to the elongated body at an intermediate wall portion along the length of the elongated body. Opposite edges of the elongate body at the intermediate wall portion at least partially define an opening through which blood flows between the treatment location and the third blood vessel when the implant is deployed.

Description

Technical Field

[0001] The present disclosure relates to devices for treating aneurysms. Background Art

[0002] An aneurysm is an abnormal bulge or bulge at a weakened blood vessel wall. Causes of aneurysms include disease, injury, and congenital abnormalities. Although aneurysms can occur in many different parts of the body, the most common locations are the aorta and cerebral vasculature. It is estimated that 2% or more of the population worldwide suffers from unruptured cerebral aneurysms. Many of these cerebral aneurysms eventually rupture, leading to serious complications, such as subarachnoid hemorrhage. Unfortunately, the prognosis for subarachnoid hemorrhage is poor. Most patients with this condition either die or suffer long-term cognitive impairment. The probability of death or disability from a ruptured aortic aneurysm may even be higher than that of a ruptured cerebral aneurysm. Fortunately, treatments for unruptured aneurysms currently exist and continue to improve. Many of these treatments involve reducing blood flow within the aneurysm and thereby promoting thrombosis and embolism. Aneurysms treated in this way are less likely to rupture than untreated aneurysms. These treatments have the potential to save thousands of lives each year. Therefore, there is a continuing public health need for improvements in these treatments. Summary of the invention

[0003] Implants according to at least some embodiments of the present technology are suitable for treating an aneurysm at a treatment location within a patient's vascular system, where a first blood vessel, a second blood vessel, and a third blood vessel converge. The implant includes an elongated first body and a spherical second body. The length of the first body extends between a first end of the first body and an opposite second end of the first body. The first body includes a first wall portion near the first end. The first wall portion includes a concave first inner surface and a convex first outer surface opposite to the first inner surface along the thickness of the first wall portion. The first body also includes a second wall portion near the second end. The second wall portion includes a concave second inner surface and a convex second outer surface opposite to the second inner surface along the thickness of the second wall portion. The first body also includes an arcuate third wall portion between the first wall portion and the second wall portion. The second body is connected to the first body via the third wall portion. The length of the second body extends laterally away from the first body. The width of the third wall portion extends between the first side of the third wall portion and the opposite second side of the third wall portion. The first body also includes a first side edge portion proximate to the first side and a second side edge portion proximate to the second side. The second side edge portion is spaced apart from the first side edge portion to define an opening. The implant is capable of transitioning between an expanded state and a delivery state. In the expanded state, the first wall portion engages the wall of the first blood vessel via the first outer surface, the second wall portion engages the wall of the second blood vessel via the second outer surface, the second body is at least partially disposed within the aneurysm, and the opening is positioned relative to the third blood vessel so that at least some blood flow between the treatment position and the third blood vessel passes through the opening. In the delivery state, the profiles of the first body and the second body across their respective lengths are more compact than in the expanded state.

[0004] The system according to at least some embodiments of the present technology is suitable for treating an aneurysm at a treatment position within a patient's vascular system. The system includes an elongated shaft defining an axial lumen and including a proximal end portion and a distal end portion opposite to the proximal end portion along the length of the shaft. The shaft is configured to move the distal end portion toward the treatment position within the blood vessel. The system also includes an implant in a low-profile delivery state within the lumen. The implant is configured to expand from the delivery state to the deployed state. The implant includes an elongated first body and a second body connected to the first body. The length of the first body extends between the first end of the first body and the opposite second end of the first body. The first body includes a first wall portion extending near the first end and along the first portion of the length of the first body, a second wall portion extending near the second end and along the second portion of the length of the first body, and a third wall portion extending between the first portion and the second portion of the length of the first body along the third portion of the length of the first body. The third wall portion is distal to the first wall portion and the second wall portion along the length of the shaft. The second body is connected to the first body via the third wall portion and is distal to the first body along the length of the axis. The distance between the second body and the first end along the length of the axis is at least 3 mm shorter than the distance between the second body and the second end along the length of the axis to facilitate sequential deployment of the first wall portion and the second wall portion at the treatment location.

[0005] Methods according to at least some embodiments of the present technology are suitable for treating an aneurysm at a treatment location within the vasculature of a patient, where a first blood vessel, a second blood vessel, and a third blood vessel converge at the treatment location. The method includes positioning a spherical body of an implant within the aneurysm, and after positioning the spherical body, positioning an elongated body of the implant within the vasculature outside the aneurysm. Positioning the elongated body includes engaging a wall of the first blood vessel via a convex first outer surface of a first wall portion of the elongated body. Positioning the elongated body also includes engaging a wall of the second blood vessel via a convex second outer surface of a second wall portion of the elongated body. Positioning the elongated body also includes engaging a wall of the vasculature between the first blood vessel and the second blood vessel via a convex third outer surface of a third wall portion of the elongated body. The third wall portion includes a width extending between a first side of the third wall portion and an opposite second side of the third wall portion. The elongated body includes a first side edge portion proximate the first side and a second side edge portion proximate the second side. The second side edge portion is spaced apart from the first side edge portion to define an opening. Positioning the elongated body also includes positioning the opening relative to the third blood vessel such that at least some blood flow between the treatment site and the third blood vessel passes through the opening.

[0006] For convenience, examples of various aspects of the present technology are described below as numbered clauses (1, 2, 3, etc.) These numbered clauses are provided as examples and not as limitations of the present technology.

[0007] Clause 1. An implant for treating an aneurysm at a treatment location within the vasculature of a patient, wherein a first blood vessel, a second blood vessel, and a third blood vessel converge at the treatment location, the implant comprising:

[0008] an elongated first body, wherein a length of the first body extends between a first end of the first body and an opposite second end of the first body, and wherein the first body comprises:

[0009] a first wall portion proximate the first end, the first wall portion comprising a concave first inner surface and a convex first outer surface opposite the first inner surface along a thickness of the first wall portion,

[0010] a second wall portion proximate the second end portion, the second wall portion comprising a concave second inner surface and a convex second outer surface opposite the second inner surface along a thickness of the second wall portion,

[0011] an arcuate third wall portion between the first wall portion and the second wall portion, wherein a width of the third wall portion extends between a first side of the third wall portion and an opposite second side of the third wall portion,

[0012] a first side edge portion, the first side edge portion being proximal to the first side, and

[0013] a second side edge portion proximate the second side, wherein the second side edge portion is spaced apart from the first side edge portion to define an opening; and

[0014] a spherical second body connected to the first body via the third wall portion, wherein the length of the second body extends laterally away from the first body, and

[0015] wherein the implant is capable of transforming between:

[0016] Expanded state, where:

[0017] the first wall portion engages a wall of the first blood vessel via the first outer surface,

[0018] the second wall portion engages the wall of the second blood vessel via the second outer surface,

[0019] The second body is at least partially disposed within the aneurysm, and

[0020] the opening is positioned relative to the third blood vessel such that at least some blood flow between the treatment site and the third blood vessel passes through the opening, and

[0021] A delivery state wherein the first body and the second body are more compact in profile across their respective lengths than in the deployed state.

[0022] Clause 2. The implant of clause 1, wherein the first body comprises:

[0023] an arcuate first end edge portion proximate to the first end; and

[0024] An arcuate second end edge portion is provided, the arcuate second end edge portion being proximate to the second end.

[0025] Clause 3. The implant of any of the preceding clauses, wherein the first side edge portion and the second side edge portion extend continuously from the first end edge portion to the second end edge portion.

[0026] Clause 4. An implant according to any one of the preceding clauses, wherein:

[0027] The first body comprises:

[0028] an arcuate first end edge portion proximate to the first end, and

[0029] an annular second end edge portion proximate the second end; and

[0030] The first wall portion is tubular.

[0031] Clause 5. The implant of any of the preceding clauses, wherein the first side edge portion and the second side edge portion extend continuously from the third wall portion to the first end edge portion.

[0032] Clause 6. An implant according to any of the preceding clauses, wherein:

[0033] The first body comprises:

[0034] an annular first end edge portion proximate to the first end, and

[0035] an annular second end edge portion proximate the second end; and

[0036] The first wall portion and the second wall portion are tubular.

[0037] Clause 7. An implant according to any of the preceding clauses, wherein the implant is capable of transitioning between the delivery state and the unconstrained state, wherein:

[0038] The second body extends away from the first body in a first direction;

[0039] The first wall portion extends away from the third wall portion in a second direction that deviates from the first direction by no more than 45 degrees; and

[0040] The second wall portion extends away from the third wall portion in a third direction that deviates from the first direction by no more than 45 degrees.

[0041] Clause 8. An implant according to any one of the preceding clauses, wherein:

[0042] The third wall portion defines an arc along a width of the third wall portion between the first side and the second side; and

[0043] The arc angle of the arc does not exceed 180 degrees.

[0044] Clause 9. The implant of any of the preceding clauses, wherein the second body comprises a concave inner surface and a convex outer surface opposite the inner surface of the second body along the thickness of the second body.

[0045] Clause 10. An implant according to any one of the preceding clauses, wherein:

[0046] The implant defines an annular recess between the first body and the second body; and

[0047] The annular recess at least partially receives the neck of the aneurysm when the implant is in the expanded state.

[0048] Clause 11. An implant according to any one of the preceding clauses, wherein:

[0049] the first body and the second body being connected to each other at a connection point along the length of the first body;

[0050] a first portion of the length of the first body extending from the connection point to the first end;

[0051] a second portion of the length of the first body extending from the connection point to the second end; and

[0052] The first portion of the length of the first body is at least 30% shorter than the second portion of the length of the first body to facilitate sequential deployment of the first and second wall portions at the treatment site.

[0053] Clause 12. An implant according to any one of the preceding clauses, wherein:

[0054] the first body and the second body being connected to each other at a connection point along the length of the first body;

[0055] a first portion of the length of the first body extending from the connection point to the first end;

[0056] a second portion of the length of the first body extending from the connection point to the second end; and

[0057] The first portion of the length of the first body is at least 3 millimeters shorter than the second portion of the length of the first body to facilitate sequential deployment of the first wall portion and the second wall portion at the treatment site.

[0058] Clause 13. An implant according to any of the preceding clauses, wherein:

[0059] The first wall portion, the second wall portion, and the third wall portion include a first mesh;

[0060] The second body includes a second mesh; and

[0061] The implant further includes a clamp at which the first mesh and the second mesh are connected to each other.

[0062] Clause 14. An implant according to any of the preceding clauses, wherein:

[0063] The second body includes a wall including a concave fourth inner surface and a convex fourth outer surface opposite the fourth inner surface along a thickness of the wall; and

[0064] The second body engages a wall of the aneurysm via the fourth outer surface when the implant is in the expanded state.

[0065] Clause 15. A system for treating an aneurysm at a treatment location within the vasculature of a patient, the system comprising:

[0066] an elongated shaft defining an axial lumen and comprising a proximal end portion and a distal end portion opposite the proximal end portion along the length of the shaft, wherein the shaft is configured to move the distal end portion within a blood vessel toward the treatment location; and

[0067] An implant in a low-profile delivery state within the lumen, wherein the implant is configured to expand from the delivery state to a deployed state, and wherein the implant comprises:

[0068] an elongated first body, wherein the length of the first body extends between a first end of the first body and an opposite second end of the first body, and wherein the first

[0069] The subjects include:

[0070] a first wall portion proximate the first end and extending along a first portion of the length of the first body,

[0071] a second wall portion proximate the second end and extending along a second portion of the length of the first body, and

[0072] a third wall portion extending along a third portion of the length of the first body between the first portion and the second portion of the length of the first body, wherein the third wall portion is distal along the length of the shaft to the first wall portion and the second wall portion, and

[0073] a second body connected to the first body via the third wall portion, wherein the second body is distal to the first body along the length of the shaft,

[0074] Wherein a distance between the second body and the first end along the length of the axis is at least 3 mm shorter than a distance between the second body and the second end along the length of the axis, so as to facilitate sequential deployment of the first wall portion and the second wall portion at the treatment position.

[0075] Clause 16. The system of clause 15, wherein the implant is capable of transitioning between the delivery state and the unconstrained state, wherein:

[0076] The second body extends away from the first body in a first direction;

[0077] The first wall portion extends away from the third wall portion in a second direction that deviates from the first direction by no more than 45 degrees; and

[0078] The second wall portion extends longitudinally away from the third wall portion in a third direction that deviates from the first direction by no more than 45 degrees.

[0079] Clause 17. A method for treating an aneurysm at a treatment location within the vasculature of a patient, wherein a first vessel, a second vessel, and a third vessel converge at the treatment location, the method comprising:

[0080] positioning a spherical body of the implant within the aneurysm; and

[0081] After positioning the spherical body, positioning the elongated body of the implant within the vasculature outside of the aneurysm, wherein positioning the elongated body comprises:

[0082] engaging a wall of the first blood vessel via a convex first outer surface of a first wall portion of the elongated body,

[0083] engaging a wall of the second blood vessel via a convex second outer surface of a second wall portion of the elongated body,

[0084] engaging a wall of the vasculature between the first blood vessel and the second blood vessel via a convex third outer surface of a third wall portion of the elongated body, the third wall portion comprising a width extending between a first side of the third wall portion and an opposing second side of the third wall portion, wherein the elongated body comprises a first side edge portion proximate the first side and a second side edge portion proximate the second side, and wherein the second side edge portion is spaced apart from the first side edge portion to define an opening, and

[0085] The opening is positioned relative to the third blood vessel such that at least some blood flow between the treatment site and the third blood vessel passes through the opening.

[0086] Item 18. The method of Item 17, further comprising moving the implant toward the treatment position within a blood vessel within an axial lumen of an elongated shaft while the implant is in a low-profile delivery state, wherein positioning the spherical body and the elongated body of the implant comprises causing relative movement between the implant and the shaft to transition the implant from the delivery state toward an expanded, deployed state.

[0087] Clause 19. A method according to any of the preceding clauses, wherein moving the implant within the blood vessel toward the treatment position comprises moving the implant within the blood vessel toward the treatment position while the third wall portion is distal to the first wall portion and the second wall portion along the length of the axis.

[0088] Clause 20. A method according to any of the preceding clauses, wherein:

[0089] The length of the elongated body extends between a first end of the elongated body and an opposite second end of the elongated body; and

[0090] Moving the implant within the blood vessel toward the treatment location includes moving the implant within the blood vessel toward the treatment location while a distance between the ball-shaped body and the first end along the length of the axis is at least 30% shorter than a distance between the ball-shaped body and the second end along the length of the axis.

[0091] Clause 21. The method of any of the preceding clauses, wherein positioning the elongated body comprises at least partially receiving a neck of the aneurysm at an annular recess defined by the implant between the spherical body and the elongated body. BRIEF DESCRIPTION OF THE DRAWINGS

[0092] Many aspects of the present technology may be better understood with reference to the following drawings. With respect to some embodiments of the present technology, the relative dimensions in the drawings may be proportional. With respect to other embodiments, the drawings may not be drawn to scale. The drawings may also be arbitrarily enlarged. For the sake of clarity, reference numeral labels for similar parts or features may be omitted when appropriate reference numeral labels for such similar parts or features are clear in the context of the specification and all drawings considered together. In addition, the same reference numerals may be used to identify similar parts or features in multiple described embodiments.

[0093] Figure 1 is a perspective view of an implant in accordance with at least some embodiments of the present technology.

[0094] Figure 2 yes Figure 1 End profile of the implant shown in .

[0095] Figure 3 yes Figure 1 Side profile view of the implant shown in .

[0096] Figure 4 is along Figure 3 The line 4-4 in Figure 1 Cross-sectional end profile of the implant shown.

[0097] Figure 5 and Figure 6 yes Figure 4 Magnified views of different corresponding parts.

[0098] Figure 7 is along Figure 3 The line 7-7 in Figure 1 Cross-sectional end profile of the implant shown.

[0099] Figure 8 is an anatomical diagram illustrating treatment locations within a patient's vasculature.

[0100] Fig. 9 yes Figure 1 Figure 4 is a side profile view of the implant shown in the unconstrained state.

[0101] Fig.10 is a partial cross-sectional side profile view of a system according to at least some embodiments of the present technology, the system comprising a shaft and a low-profile delivery state within the shaft Figure 1 The implant shown in .

[0102] Fig.11 yes Figure 1 The implant shown in Figure 8 Partial cross-sectional side profile view of the treatment site shown in the expanded state.

[0103] Figure 12 to Figure 14 yes Fig.10 The system shown in Figure 1 The implant shown in Figure 8 Partial cross-sectional side profile views at different corresponding times during deployment at the treatment location shown in .

[0104] Fig.15 yes Fig.14 An enlarged cross-sectional view of a portion of.

[0105] Figures 16 to 20 yes Fig.10 The system shown in Figure 1 The implant shown in Figure 8 Additional partial cross-sectional side profile views at different corresponding times during deployment at the treatment location shown in .

[0106] Figure 21 to Figure 23 are perspective views of implants according to other embodiments of the present technology. DETAILED DESCRIPTION

[0107] Implants according to at least some embodiments of the present technology help treat aneurysms at vascular junctions (e.g., bifurcations and / or trifurcations). As discussed above, treatment of aneurysms may involve reducing blood flow within the aneurysm and thereby promoting thrombosis and embolism. A method of reducing blood flow within an aneurysm includes deploying an occluding device (e.g., an expandable aggregate of a mesh or coil structure) within the aneurysm. However, aneurysms at vascular junctions typically have larger necks than other aneurysms. This can complicate the stable positioning of the occluding device within these aneurysms. Another method includes deploying a flow diversion device (e.g., a stent) within the blood vessel where the aneurysm originates. For example, such a device can be positioned across the neck of the aneurysm and expanded to be juxtaposed with the vessel wall around the neck. With the device in place, the blood flowing into the aneurysm can be sufficiently reduced to cause desired thrombosis and embolism within the aneurysm. Conventional flow diversion devices are tubular and are held in place by outward forces on the vessel wall rather than by interaction with the neck of the aneurysm. However, at a vascular junction, a tubular device extending across the neck of an aneurysm may also extend across the flow paths of one or more vessels that converge at the junction. This may undesirably interfere with normal blood flow through the junction.

[0108] Implants according to at least some embodiments of the present technology include intravascular anchoring and / or occlusion portions connected to intravascular anchoring and / or flow diversion portions. These portions surprisingly complement each other to facilitate the treatment of aneurysms at vascular junctions. For example, the intravascular portion may include a first wing and a second wing that conformally engage the first and second blood vessels on opposite sides of the aneurysm at the vascular junction. Between the wings, the intravascular portion may include a bridging middle portion defining an opening through which blood from a third blood vessel at the junction enters or leaves the junction with little or no obstruction. The intrasaccular portion may contribute to the alignment of the opening with the third blood vessel. The wings may contribute to the stable positioning of the intrasaccular portion, thereby reducing or eliminating the risk of any dislocation, even if the neck of the aneurysm is large. In this or another way, implants according to at least some embodiments of the present technology contribute to the treatment of aneurysms at vascular junctions. Additionally or alternatively, implants and related devices, systems, and methods according to embodiments of the present technology may at least partially solve one or more other problems associated with conventional techniques, whether or not these problems are described herein.

[0109] References Figures 1 to 23Specific details of several embodiments of the present technology are disclosed. It should be noted that, in general, in addition to those embodiments disclosed herein, other embodiments are also within the scope of the present technology. For example, embodiments of the present technology may have configurations, components, and / or operations that are different from the configurations, components, and / or operations disclosed herein. In addition, it should be understood by those of ordinary skill in the art that embodiments of the present technology may have configurations, components, and / or operations other than those disclosed herein, and these and other embodiments may not have the configurations, components, and / or operations disclosed herein without departing from the present technology.

[0110] Figure 1 and Figure 2 1 and 2 are perspective views and end profile views, respectively, of an implant 100 according to at least some embodiments of the present technology. Figure 1 and Figure 2 , the implant 100 may include a first body 102 and a second body 104 that are operably connected to each other. The first body 102 may extend along a length L1 between a first end a1 and a second end b1, and along a width W between a first side c1 and a second side d1. The second body 104 may extend along a length L2 between a first end a2 and a second end b2. For example, the second body 104 may extend laterally away from the first body 102 along the length L2. The first body 102 and the second body 104 may be flexible, or capable of transitioning between a variety of forms. Figure 1 and Figure 2 In the form shown in , the first body 102 is elongated and the second body 104 is spherical and / or spheroidal. The second body 104 may have a diameter D perpendicular to the length L2. The respective shapes of the first body 102 and the second body 104 may correspond at least in part to the shape of the anatomical features with which the first body 102 and the second body 104 interact when the implant 100 is deployed at the treatment position within the patient's vascular system. For example, the first body 102 may be shaped to conformally engage the vessel wall near the aneurysm, and the second body 104 may be shaped to conformally engage the aneurysm wall. In at least some embodiments, when the second body 104 is unconstrained, the diameter D is in the range of 4 mm to 12 mm. In these and other embodiments, when the first body 102 is unconstrained, the width W may be in the range of 2 mm to 4 mm. In addition, when the first body 102 and the second body 104 are unconstrained, the width W may be less than the diameter D.

[0111] The first body 102 may include a first end edge portion 106 proximate to the first end a1 and a second end edge portion 108 proximate to the second end b1. In the illustrated embodiment, the first end edge portion 106 and the second end edge portion 108 are curved and / or arcuate and are in respective planes perpendicular to the length L1. In other embodiments, the counterparts of one or both of the first end edge portion 106 and the second end edge portion 108 may have different shapes, positions and / or features. For example, the counterparts of the first end edge portion 106 and the second end edge portion 108 may be straight, annular and / or deviate from respective planes perpendicular to the length L1. Referring again to Figure 1 and Figure 2 , the first body 102 may include a first side edge portion 110 close to the first side c1 and a second side edge portion 112 close to the second side d1. The first side edge portion 110 and the second side edge portion 112 may be spaced apart to define an opening 113. In the illustrated embodiment, the first side edge portion 110 and the second side edge portion 112 are straight and parallel to the length L1. The first side edge portion 110 and the second side edge portion 112 in the illustrated embodiment also extend continuously between the first end edge portion 106 and the second end edge portion 108. In other embodiments, the counterparts of one or both of the first side edge portion 110 and the second side edge portion 112 may have different shapes, positions and / or features. For example, the counterparts of the first side edge portion 110 and the second side edge portion 112 may be curved, arc-shaped and / or non-parallel to the length L1. As another example, corresponding ones of the first side margin portion 110 and the second side margin portion 112 may extend along only a portion of the length L1 , such as a portion spaced apart from one or both of the first end a1 and the second end b1 .

[0112] Figure 3 is a side profile view of implant 100 . Figure 4 is along Figure 3 A cross-sectional end profile view of the implant 100 taken along the midline 4-4. Figures 1 to 4 , the first body 102 may be at least primarily comprised of a wall 114 having an outer surface 116 and an inner surface 118 opposite the outer surface 116 along the thickness of the wall 114. The thickness may be many times less than the length L1. For example, the average thickness of the entire wall 114 may not exceed 0.5% of the length L1 (e.g., 0.05% to 0.5% of the length L1 or 0.05% to 0.3% of the length L1). In these and other cases, the thickness may not exceed 0.1 mm (e.g., in the range of 0.01 mm to 0.1 mm). These and other dimensional features of the first body 102 may be used to reduce blood flow obstruction, increase flexibility, and / or for one or more other reasons.

[0113] As part of the wall 114, the first body 102 may include a first wall portion 114a close to the first end a1, a second wall portion 114b close to the second end b1, and a third wall portion 114c therebetween. One, some or all of the first wall portion, the second wall portion, and the third wall portion 114a-114c may be curved and / or arcuate along the width W. This may be useful, for example, when the implant 100 is deployed at the treatment position, to facilitate the shape correspondence between the first wall portion, the second wall portion, and the third wall portion 114a-114c and one or more blood vessel walls. Relatedly, the first wall portion 114a may include a convex first outer surface 116a and a concave first inner surface (not shown) opposite to the first outer surface 116a along the thickness of the first wall portion 114a. Similarly, the second wall portion 114b may include a convex second outer surface 116b and a concave second inner surface (not shown) opposite to the second outer surface 116b along the thickness of the second wall portion 114b. Likewise, the third wall portion 114c may include a convex third outer surface 116c and a concave third inner surface (not shown) opposite the third outer surface 116c along the thickness of the third wall portion 114c.

[0114] Implant 100 may define an annular recess 120 between first body 102 and second body 104. Second body 104 may be connected to first body 104 at connection point e1 along length L1 via third wall portion 114c. In at least some cases, third wall portion 114c is centered at connection point e1 and includes a portion of wall 114 of first body 102 adjacent to recess 120. Second body 104 may be radially symmetrical about an axis parallel to length L2, perpendicular to length L1, and passing through connection point e1. Figure 3 As shown, the first portion L1a of the length L1 extending from the connection point e1 to the first end a1 may be shorter than the second portion L1b of the length L1 extending from the connection point e1 to the second end b1. For example, the first portion L1a of the length L1 may be at least 20%, at least 30%, or at least 40% shorter than the second portion L1b of the length L1. Additionally or alternatively, the first portion L1a of the length L1 may be at least 2 mm, at least 3 mm, or at least 4 mm shorter than the second portion L1b of the length L1. As further discussed below, this length difference may be useful, for example, to facilitate sequential deployment of the first wall portion 114a and the second wall portion 114b at the treatment location.

[0115] In the illustrated embodiment, the second body 104 includes a wall 122 having a convex outer surface 124 and a concave inner surface 126 opposite the outer surface 124 along the thickness of the wall 122. The second body 104 may surround a spheroid cavity 128, which is configured to be empty (as shown) and / or at least partially filled with an intrasaccular occlusive structure (e.g., an expandable agglomerate of a mesh or coil structure) when the implant 100 is deployed at the treatment position. In other embodiments, the second body 104 may have another suitable form. For example, the counterpart of the second body 104 may include an intrasaccular occlusive structure that is not surrounded by the counterpart of the wall 122. In addition, the counterpart of the second body 104 may have a shape different from a spheroid. Relatedly, the counterpart of the second body 104 may be configured to conformally engage some of the aneurysm wall, not engage the aneurysm wall, or engage all of the aneurysm wall.

[0116] Reference again Figures 1 to 4 , walls 114, 122 may include a mesh of one or more interconnected leads, which are woven together and / or formed together (e.g., 3D printed) into a network so that walls 114, 122 can expand and contract. Alternatively or in addition, walls 114, 122 may include perforated sheets. In addition, walls 114, 122 may be formed together or separately. In the latter case, walls 114, 122 may be welded, soldered, glued, clamped or otherwise connected to each other after formation. Suitable materials for walls 114, 122 include biocompatible metal alloys and polymers. For example, walls 114, 122 may include a Nitinol-platinum alloy drawn filling tube wire with an average diameter of 20 microns to 30 microns. When formed by leads, the density of the leads in walls 114, 122 may be selected to achieve a desired level of porosity and / or flexibility. In some embodiments, the wall 114 of the first body 102 includes 96 to 144 individual leads. In these and other embodiments, the wall 122 of the second body 104 may include 12 to 36 leads. Other structural configurations, materials, and numbers of leads are also possible.

[0117] One or more features of the walls 114, 122 may vary throughout the implant 100 based on the intended location and / or function of a particular portion of the implant 100. For example, a portion of the wall 114 of the first body 102 that is configured to be positioned above the neck of an aneurysm (e.g., all or some of the third wall portion 114c) may have a lower porosity and / or greater surface coverage than the wall 122 of the second body 104 or other portions of the wall 114 of the first body 102. This may be used, for example, to promote thrombosis and embolism within an aneurysm without excessively reducing the flexibility or other potentially desirable mechanical properties of the entire implant 100. Additionally or alternatively, one or more portions of the implant 100 that are configured to be anchored to the vessel wall (e.g., the first wall portion 114a and the second wall portion 114b) may have a greater porosity, a lower surface coverage, and / or be configured to apply a greater long-term outward force than other portions of the implant 100.

[0118] Figure 5 and Figure 6 yes Figure 4 Specifically, Figure 5 A portion of the second body 104 at a second end b2 having a length L2 is shown, and Figure 6 The connection 130 between the first body 102 and the second body 104 at the first end a2 having a length L2 is shown. Figure 5 and Figure 6 As shown, the implant 100 may include a first clamp 132 at the connection portion 130 and a second clamp 134 at a portion of the second body 104 at the second end b2 of length L2. The first clamp 132 and the second clamp 134 may individually include a plug 136 (individually identified as a plug 136a, 136b) and a ring 138 (individually identified as a ring 138a, 138b) extending around the corresponding plug 136a, 136b. With respect to one or both of the first clamp 132 and the second clamp 134, the corresponding plug 136a, 136b and / or the ring 138a, 138b may be more radiopaque than the wall 114, 122. In at least some embodiments, with respect to one or both of the first clamp 132 and the second clamp 134, the corresponding plug 136a, 136b and the ring 138a, 138b are coaxially nested radiopaque marker bands that are curled together.

[0119] Forming the implant 100 may include creating a gap at the third wall portion 114c in the precursor of the first body 102 along approximately the middle position of the width w. Forming the gap may include shifting the lead at the third wall portion 114c so that the third wall portion 114c becomes elastically biased toward the closed gap. The wall 122 of the second body 104 may be tubular before being connected to the wall 114 of the first body 102. In these and other cases, the end of the wall 122 of the second body 104 may be inserted through the gap in the wall 114 of the first body 102 and fixed between the plug 136a and the ring 138a to form the first fixture 132. For example, the end of the wall 122 of the plug 136a, the ring 138a, and the second body 104 may be clamped against the wall 114 of the first body 102 and curled together before or after clamping. The plug 136a may be configured to collapse from an annular form to a non-annular form in response to curling. The second clamp 134 may be formed in a similar manner to close the opposite end of the wall 122 of the second body 104. By installing the first clamp 132 and the second clamp 134 or in another suitable manner, the wall 122 of the second body 104 may be changed from a tubular form to a spherical and / or spheroidal form.

[0120] Figure 7 is along Figure 3 A cross-sectional end profile view of the implant 100 taken along the midline 7-7. Figure 1 , Figure 2 and Figure 7 , the wall 114 of the first body 102 may define an arc B along the width W between the first side c1 and the second side d1. The arc B may have an arc angle C. In the illustrated embodiment, the opening 113, the arc B, and the arc angle C are consistent along the length L1. In other embodiments, the counterpart of the first body 102 may define an opening only along a portion of the length L1. In these and other embodiments, the arc B may not exist or may be different in form and / or size at different portions of the length L1. For example, the first wall portion 114a, the second wall portion 114b, and the third wall portion 114c may individually define different corresponding arcs or no arcs.

[0121] Figure 8is an anatomical diagram showing a treatment position TL within the vascular system of a patient where multiple blood vessels converge. For example, the treatment position TL may include a junction J at which a parent blood vessel P is divided into two or more branch blood vessels B1, B2. An aneurysm A located between the branch blood vessels B1, B2 includes a generally spherical sac S and a neck N located between the sac S and the junction J. Various aspects of the technology of the present invention are further described below primarily in the context of the treatment position TL. However, it should be understood that implants and related devices, systems, and methods according to embodiments of the technology of the present invention can be used in various other treatment positions. In another compatible treatment position, the aneurysm to be treated is between the parent blood vessel and the branch blood vessel, rather than between the two branch blood vessels. In addition, the branch blood vessels at the alternative treatment position may be at significantly different angles relative to the branch blood vessels B1, B2, have significantly different sizes, and / or exist in different numbers (e.g., three or more). In addition, the aneurysm to be treated at the alternative treatment position may be offset relative to the junction. For example, the neck of such an aneurysm may face and / or be open to a branch vessel rather than to the parent vessel, and / or be inclined relative to a plane formed by the convergence of the vessels at the junction, such as when the junction is at a Figure 8 When represented in the manner indicated by the junction point J shown in FIG. 1 , the treatment position TL may be tilted inward or outward from the page. Other variations relative to the treatment position TL are also possible.

[0122] Implant 100 and related devices, systems, and methods according to embodiments of the present technology may be configured to treat aneurysms in any vasculature of a patient, including, for example, cerebral arteries, peripheral arteries, coronary arteries, pulmonary arteries, abdominal arteries, thoracic arteries, aorta, etc. Figure 8 As shown, blood (indicated by arrows F) flows from the parent vessel P into the branch vessels B1, B2 via the confluence point J at the treatment location TL. Blood also flows into the aneurysm A. This blood flow can cause the aneurysm A to rupture. Therefore, even without closing the aneurysm, simply reducing or eliminating the blood flow into the aneurysm A can reduce the risk of aneurysm rupture. However, as discussed above, reducing the blood flow into the aneurysm A can also lead to thrombosis, embolization, healing and / or other forms of natural closure of the aneurysm A, thereby resulting in a greater reduction in the risk of aneurysm A rupture.

[0123] Reference together Figure 1 , Figure 7 and Figure 8, the first wall portion 114a may define an arc B, which is sized to promote a stable connection between the first wall portion 114a and the branch vessel B1. Similarly, the second wall portion 114b may define an arc B, which is sized to promote a stable connection between the second wall portion 114b and the branch vessel B2. In at least some embodiments, one or both of the first wall portion 114a and the second wall portion 114b define a corresponding arc B having an arc angle C of about 180 degrees or in the range of 90 degrees to 270 degrees. The third wall portion 114c may define an arc B that is small enough to reduce or eliminate blood flow obstruction between the confluence point J and the parent vessel p. In at least some embodiments, the third wall portion 114c defines an arc B having an arc angle C of about 180 degrees or in the range of 60 degrees to 220 degrees.

[0124] Fig. 9 is a side profile view of the implant 100 in an unconstrained state. Figure 3 and Figure 8 , the second body 104 can be spherical and / or spheroidal, and the first body 102 can conformally extend around a portion of the second body 104 proximal to the first body 102 such that the recess 120 is closed when the implant 100 is in an unconstrained state. Figure 3 In contrast to the state shown in Figure 8 In the unconstrained state shown in FIG, the length L1 can be curved, such as forming a U-shape and / or a J-shape. In addition, the first wall portion 114a and the second wall portion 114b can extend away from the third wall portion 114c in respective directions, offset by no more than 45 degrees from the direction in which the second body 104 extends away from the third wall portion 114c. These and / or other shape characteristics of the implant 100 in the unconstrained state can contribute to the compatibility of the implant 100 with treatment sites of various sizes and configurations. For example, referring to Figure 8 and Fig. 9 , the first wall portion 114a and the second wall portion 114b can be configured to be elastically bent to accommodate various angles between the branch vessels B1, B2 or between one of the branch vessels B1, B2 and the parent vessel P, when the aneurysm to be treated is located between one of the branch vessels B1, B2 and the parent vessel P. The shape of the implant 100 in the unconstrained state can be thermally set (e.g., by heat treatment), structurally set (e.g., by robotic lead bending), and / or set in another suitable manner.

[0125] Fig.102 is a partial cross-sectional side profile view of a system 200 including an implant 100 according to at least some embodiments of the present technology. The system 200 may include a handle 202 and an elongated shaft 204 connected to the handle 202. The shaft 204 may have a proximal end portion 204a closest to the handle 202 and a distal end portion 204b opposite the proximal end portion 204a along the length of the shaft 204. The shaft 204 may define an axial lumen 206 extending along the length of the shaft 204 between the proximal end portion 204a and the distal end portion 204b. The system 200 may also include a mandrel 208 slidably disposed within the lumen 206. At the handle 202 or another suitable location, the system 200 may include an actuator 210 operably connected to the mandrel 208 and / or the shaft 204. For example, the actuator 210 can be configured to move the mandrel 208 longitudinally within the lumen 206, to move the shaft 204 longitudinally relative to the mandrel 208 (e.g., extend and / or retract), to deflect the distal tip of the mandrel 208 laterally, to deflect the distal tip of the shaft 204 laterally, and / or to otherwise manipulate the mandrel 208 and / or shaft 204 during the deployment of the implant 100 at the treatment position. The system 200 may include an implant 100 in a delivery state within the lumen 206, such as within a portion of the lumen 206 at the distal end portion 204b of the shaft 204. The shaft 204 can be configured to move the distal end portion 204b toward the treatment position within the blood vessel, thereby moving the implant 100 to the treatment position. Alternatively or in addition, the implant 100 can be configured to move longitudinally through the lumen 206, such as along a guide wire (not shown).

[0126] Fig.11 is a partial cross-sectional side profile view of the implant 100 in the expanded state at the treatment position TL. Figures 9 to 11 , the implant 100 can be in an unconstrained state ( Fig. 9 ), Delivery Status( Fig.10 ) and expanded state ( Fig.11 ). The delivery state can be a low-profile state from which the implant 100 expands (e.g., self-expanding and / or expanding in response to an applied expansion force, such as an expansion force from a balloon) to transition to an expanded state or an unconstrained state. For example, when the implant 100 is in the delivery state, the profiles of the first body 102 and the second body 104, respectively, across the lengths L1 and L2, can be more compact than when the implant 100 is in the expanded state or the unconstrained state. Fig.10 As shown, when the implant 100 is in the delivery state, the second body 104 can be distal to the first body 102. In addition, the third wall portion 114c can be curved so that the first wall portion 114a and the second wall portion 114b extend proximally from the third wall portion 114c. Figure 1 and Fig.10, a first distance along the axis 204 between the second body 104 and the first end a1 of the first body 102 having a length L1 may be shorter than a second distance along the axis 204 between the second body 104 and the second end b1 of the first body 102 having a length L1. For example, the first distance may be at least 20%, at least 30%, or at least 40% shorter than the second distance. Additionally or alternatively, the first distance may be at least 2 mm, at least 3 mm, or at least 4 mm shorter than the second distance.

[0127] Reference together Figure 1 , Figure 3 and Fig.11 , when the implant 100 is in the deployed state at the treatment location TL, the first wall portion 114a may conformally engage the wall of the branch vessel B1 via the first outer surface 116a. Similarly, the second wall portion 114b may conformally engage the wall of the branch vessel B2 via the second outer surface 116b. The third wall portion 114c may conformally engage the wall of the vascular system between the branch vessels B1 and B2 via the third outer surface 116c. The second body 104 may be at least partially disposed within the aneurysm A and may engage the wall of the aneurysm A via the outer surface 124. The recess 120 may at least partially receive the neck N of the aneurysm A. The opening 113 may be positioned relative to the parent vessel P such that at least some of the blood flowing from the parent vessel P into the treatment location TL passes through the opening 113. Similarly, when the implant 100 is deployed at an alternative treatment location where the aneurysm is located between the parent vessel and the first branch vessel, at least some of the blood flow from such treatment location to the second branch vessel at the treatment location may pass through the opening 113. As Fig.11 As indicated by arrow F in FIG. 1 , deploying implant 100 at treatment location TL may at least partially reduce blood flow within aneurysm A while having little or no effect on blood flow from parent vessel P to branch vessels B1 , B2 .

[0128] Figure 12 to Figure 14 and Figures 16 to 20 2 are partial cross-sectional side profile views of system 200 at different times during deployment of implant 100 at treatment location TL. According to at least some embodiments of the present technology, deployment of implant 100 can be part of a method for treating an aneurysm A at treatment location TL. For simplicity, aspects of the method are primarily described in the context of system 200 and implant 100. However, it should be understood that the method, when appropriate, and / or portions of the method, when appropriate, can be practiced with respect to other systems and devices according to embodiments of the present technology. Fig.11 As shown, the method may include moving the implant 100 toward the treatment location TL within the blood vessel while the implant 100 is in a low-profile delivery state within the axial lumen 206 of the shaft 204. The method may also include causing relative movement between the implant 100 and the shaft 204. Fig.12 As shown, such relative movement can transition the implant 100 from the delivery state toward the expanded, deployed state at the treatment location TL.

[0129] Prior to ejecting the implant 100 from the shaft 204, the distal tip of the shaft 204 may be located within the aneurysm A. Alternatively, prior to ejecting the implant 100 from the shaft 204, the distal tip of the shaft 204 may be located outside the aneurysm A. In either case, the method may include deploying the second body 104 within the aneurysm A after moving the implant 100 toward the treatment location TL within the vessel and prior to deploying the first body 102. Deploying the second body 104 within the aneurysm A may include moving the implant 100 distally relative to the shaft 204, such as by pushing the implant 100 via the mandrel 208. Alternatively or in addition, deploying the second body 104 within the aneurysm A may include retracting the shaft 204 proximally relative to the implant 100. When the second body 104 is released from the shaft 204, the second body 104 may self-expand toward the form it had when the implant 100 was in the deployed state. As discussed above, this form may be spherical and / or spheroidal. In addition, the unconstrained diameter D of the second body 104 can be slightly larger than the effective diameter of the aneurysm A (e.g., 10% to 40% larger) so that the second body 104 applies a small force radially outward against the wall of the aneurysm A. When the second body 104 is deployed within the aneurysm A and / or at another time during the method, the first clamp 132 ( Figure 6 ) can be visualized using fluoroscopy, such as by attaching the junction e1 ( Figure 3 ) is aligned with the center of the neck N of the aneurysm A. Additionally or optionally, the second clamp 134 ( Figure 5 ) can be visualized using fluoroscopy, such as to confirm that the second body 104 is properly deployed within the aneurysm A.

[0130] Fig.15 yes Fig.14 An enlarged cross-sectional view of a portion of Fig.15 As shown, the mandrel 208 may be detachably connected to the implant 100. For example, the mandrel 208 may include a distal tip 212 and a detachment mechanism 214, by which the mandrel 208 is detachably connected to the implant 100 via the first clamp 132. The detachment mechanism 214 may include a heater 216 located at the distal tip 212 and an electrical conductor 218 ( Fig.10). The detachment mechanism 214 may also include a volume of heat-sensitive adhesive 220 (e.g., solder) between the distal tip 212 and the first clamp 132. The handle 202 may include a power source (not shown) and a switch (also not shown) that causes electricity to flow from the power source via the electrical conductor 218 to the heater 216. This may cause the heater 216 to heat the adhesive 220 to a temperature sufficient to cause the adhesive 220 to reflow or otherwise reduce or eliminate adhesion between the distal tip 212 and the first clamp 132. Thus, during deployment of the implant 100 at the treatment location TL, the implant 100 may be released from the mandrel 208 at an appropriate time, such as after the second body 104 has expanded within the aneurysm A, as shown in FIG. Fig.14 In other embodiments, counterparts to the separation mechanism 214 may be configured to separate the implant 100 electrolytically, mechanically, and / or chemically in addition to or in lieu of thermal separation. Furthermore, the separation mechanism 214 may be eliminated. For example, the mandrel 208 may simply abut the first clamp 132 or another suitable portion of the implant 100.

[0131] Deploying the implant 100 at the treatment location TL may also include deploying the first body 102 within the vasculature outside the aneurysm A after deploying the second body 104 within the aneurysm A. Fig.16 As shown, after the implant 100 is separated from the core shaft 208, the shaft 204 can be repositioned toward the branch vessel B1. This can cause some of the third wall portion 114c to conformally engage the wall of the vasculature between the branch vessels B1, B2 via the third outer surface 116c. The core shaft 208 can then be moved distally relative to the shaft 204 so that the distal tip 212 contacts the first inner surface of the first wall portion 114a. Fig.17 As shown, first wall portion 114a can then conformally engage the wall of branch vessel B1 via first outer surface 116a. This can occur in response to a force from mandrel 208 against the inner surface of first wall portion 114a, in response to self-expansion of first wall portion 114a in the absence and / or reduction of constraints from shaft 204, and / or in another suitable manner.

[0132] like Fig.18 As shown, once the first wall portion 114a is deployed, the mandrel 208 can be moved proximally relative to the shaft 204 away from the implant 100. Fig.19 As shown, the shaft 204 can then be repositioned toward the branch vessel B2. This can cause the remainder of the third wall portion 114c to conformally engage the wall of the vasculature between the branch vessels B1, B2 via the third outer surface 116c. Figure 3 and Fig.19 When the third wall portion 114c is expanded, the neck N of the aneurysm A can be at least partially received at the recess 120. The shaft 204 can be extended from its Fig.19 The shaft 204 may then be withdrawn from the treatment location TL, as shown in FIG. 2 . Fig. 20 As shown. Figure 3 and Fig. 20 The overall deployment of the first body 102 can position the opening 113 relative to the parent blood vessel P so that at least some blood flow between the treatment location TL and the parent blood vessel P passes through the opening 113 .

[0133] exist Figures 12 to 20 In the method shown, the shaft 204 and the mandrel 208 are manipulated to guide the deployment of the first body 102 at the treatment location TL. In other embodiments, the deployment of the first body 102 at the treatment location TL may involve only one or neither of these processes. For example, in some embodiments, after separation from the implant 100, the mandrel 208 is retracted proximally relative to the shaft 204, rather than being used to guide the deployment of the first body 102 at the treatment location TL. In other embodiments, the mandrel 208 can be used to guide the deployment of the first body 102 at the treatment location TL without guiding the shaft 204 toward the branch vessels B1, B2. Reference together Figure 3 and Figures 12 to 20 , the difference between the first portion L1a and the second portion L1b of the length L1 can facilitate the sequential deployment of the first wall portion 114a and the second wall portion 114b at the treatment location TL. For example, even without the presence of the mandrel 208 as a manipulator, the proximal movement of the shaft 204 relative to the implant 100 (e.g., when the implant 100 is anchored by the neck N of the aneurysm A) can cause the first wall portion 114a to be released from the shaft 204 before the second wall portion 114b is released from the shaft 204. This sequential rather than simultaneous release of the first wall portion 114a and the second wall portion 114b from the shaft 204 is useful, for example, to allow the clinician to better control the alignment of the first wall portion 114a and the second wall portion 114b with the branch vessels B1 and B2, respectively. This alignment can be controlled, for example, via the rotation of the shaft 204 about an axis parallel to the length of the shaft 204. Additionally or alternatively, sequentially rather than simultaneously releasing the first wall portion 114a and the second wall portion 114b from the shaft 204 may help to pre-position the first wall portion 114a and the second wall portion 114b in the branch vessels B1, B2, respectively, or to otherwise guide the deployment of the first wall portion 114a and the second wall portion 114b by manipulating the core shaft 208 and / or the shaft 204.

[0134] Fig.21300 is a perspective view of another embodiment of an implant according to the present technology. The implant 300 may include the same Figures 1 to 9 The features described for the implant 100 are similar or identical to those described for the implant 100. Figures 1 to 9 and Fig.21 Unlike implant 100, implant 300 includes an elongated body 302 extending along a width W, which is different at different parts of the length L1. For example, the body 302 may include a first side edge portion 304 and a second side edge portion 306 that are opposite, and are bent inwardly at an intermediate wall portion 308 centered at the connection point e1. The intermediate wall portion 308 may be spaced apart from the first end a1 and the second end b1. For example, the intermediate wall portion 308 of the implant 300 may have the same position along the length L1 as the third wall portion 114c of the implant 100. In at least some cases, the intermediate wall portion 308 has a lower porosity than other parts of the body 302.

[0135] Forming the implant 300 may include the operations described above for forming the implant 100, followed by deforming the middle wall portion 308. Such deformation may include reducing the gaps between the leads at the middle wall portion 308, such as by tightening the braiding of the leads at the middle wall portion 308. This may both reduce the width W of the middle wall portion 308 and reduce the porosity of the middle wall portion 308. The reduced width W of the middle wall portion 308 achieved in the manner described or in another suitable manner may be used to reduce the probability that the middle wall portion 308 will block blood flow into or out of a blood vessel directed toward an aneurysm proximate to the middle wall portion 308 when the implant is deployed at the treatment location. For example, referring to Figure 8 and Fig.21 , when the implant 300 is deployed at the treatment location TL, the reduced width W of the middle wall portion 308 can reduce the probability that the middle wall portion 308 blocks blood flow between the junction J and the parent vessel P. The lower porosity of the middle wall portion 308 achieved in this manner or in another suitable manner can be used to reduce blood flow into the aneurysm A when the implant 300 is deployed at the treatment location TL.

[0136] Fig. 22 400 is a perspective view of an implant 400 according to another embodiment of the present technology. Implant 400 may include the same Figures 1 to 9 The features described for the implant 100 are similar or identical to those described for the implant 100. Figures 1 to 9 and Fig. 22Unlike implant 100, implant 400 has an elongated body 402 including a tubular first wall portion 404 near the first end a1 and a tubular second wall portion 406 near the second end b1. Relatedly, implant 400 may have an annular first end edge portion 408 near the first end a1 and an annular second end edge portion 410 near the second end b1. The first wall portion 404 and the second wall portion 406 and the first end edge portion 408 and the second end edge portion 410 of implant 400 may have the same respective positions along the length L1 as the first wall portion 114a and the second wall portion 114b and the first end edge portion 106 and the second end edge portion 108 of implant 100. Implant 400 may also include a third wall portion 412, the position of which along the length L1 is the same as the position of the third wall portion 114c of implant 100 along the length L1. Implant 400 may also include a first side edge portion 414 and an opposing second side edge portion (not shown) similar to first side edge portion 110 and second side edge portion 112 of implant 100, but terminated at first wall portion 404 and second wall portion 406 instead of first end portion a1 and second end portion b1. Figure 2 , Figure 8 and Fig. 22 In at least some cases, the distance L3 between the first wall portion 404 and the second wall portion 406 is equal to or greater than the diameter D, in the range of 4 mm to 12 mm, and / or at least about twice the diameter of the neck N of the aneurysm A.

[0137] Fig.23 5 is a perspective view of an implant 500 according to another embodiment of the present technology. Implant 500 may include the same Figures 1 to 9 The features described for the implant 100 are similar or identical to those described for the implant 100. Figures 1 to 9 23, unlike implant 100, implant 500 has an elongated body 502, which includes a tubular wall portion 504 close to the second end b1. Relatedly, implant 500 may have an annular end edge portion 506 close to the second end b1. The wall portion 504 and the end edge portion 506 of implant 500 may have the same corresponding positions along the length L1 as the second wall portion 114b and the second end edge portion 108 of implant 100. Implant 500 may also include a first side edge portion 508 and an opposite second side edge portion (not shown), similar to the first side edge portion 110 and the second side edge portion 112 of implant 100, but terminated at the wall portion 504 and the first end a1, rather than the first end a1 and the second end b1.

[0138] refer to Figure 3In another embodiment, the counterpart of implant 100 includes a tubular wall portion and an annular end edge portion, instead of the arcuate first wall portion 114a and the arcuate first end edge portion 106. It may be useful to make the counterpart of first wall portion 114a tubular rather than arcuate, for example, to reduce or eliminate the probability that first wall portion 114a moves out of engagement with the vessel wall and potentially interferes with blood flow through the vessel. Similarly, making the counterpart of second wall portion 114b tubular rather than arcuate (e.g., as Fig. 22 The second body 104 may be provided with an arched wall configuration (shown in Figure 104) that is useful, for example, to reduce or eliminate the probability that the second wall portion 114a moves out of engagement with the vessel wall and potentially interferes with blood flow through the vessel. A tubular wall configuration rather than an arched wall configuration may also provide a stronger anchoring and / or have other advantages for the second body 104. An arched wall configuration rather than a tubular wall configuration may provide advantages such as greater flexibility and a lower delivery profile. Therefore, according to various embodiments of the present technology, both the arched wall configuration and the tubular wall configuration are useful in implants.

[0139] The present disclosure is not intended to be exhaustive or to limit the present invention technology to the precise form disclosed herein. Although specific embodiments are disclosed herein for illustrative purposes, various equivalent modifications are possible without departing from the present invention technology as will be appreciated by those of ordinary skill in the relevant art. In some cases, well-known structures and functions are not shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the present technology. Although the steps of the method can be presented in a particular order herein, in alternative embodiments, the steps can have another suitable order. Similarly, in other embodiments, certain aspects of the present invention technology disclosed in the context of a particular embodiment can be combined or omitted. In addition, although advantages associated with certain embodiments can be disclosed herein, other embodiments can also show such advantages, and not all embodiments need to show such advantages or other advantages disclosed herein to fall within the scope of the present technology. The present disclosure and related technologies can include other embodiments not explicitly shown or described herein.

[0140] Throughout this disclosure, unless the context clearly states otherwise, the singular terms "one / a kind" and "the" include plural indicators. Similarly, unless the word "or" is explicitly limited to refer to a list of two or more items, only a single item mutually exclusive with other items, otherwise the use of "or" in such a list should be interpreted as including any single item in (a) the list, (b) all items in the list, or (c) any combination of items in the list. In addition, the use of the terms "include", "comprise" and the like throughout this disclosure means at least including the features, so that any greater number of the same features and / or one or more other types of features are not excluded. Directional terms such as "upper", "lower", "front", "back", "vertical" and "horizontal" can be used herein to express and illustrate the relationship between various structures. It should be understood that such terms do not represent absolute orientation. In addition, the reference to "an embodiment", "embodiment" or similar phrases herein means that the specific features, structures, operations or characteristics described in conjunction with such phrases can be included in at least one embodiment of the present invention. Therefore, such phrases used herein do not necessarily all refer to the same embodiment. Finally, it should be noted that the various specific features, structures, operations, and characteristics of the embodiments described herein may be combined in any suitable manner in additional embodiments according to the present technology.

Claims

1. An implant for treating an aneurysm at a treatment location within the vasculature of a patient, wherein a first blood vessel, a second blood vessel, and a third blood vessel converge at the treatment location, the implant comprising: an elongated first body, wherein a length of the first body extends between a first end of the first body and an opposite second end of the first body, and wherein the first body comprises: a first wall portion proximate the first end, the first wall portion comprising a concave first inner surface and a convex first outer surface opposite the first inner surface along a thickness of the first wall portion, a second wall portion proximate the second end portion, the second wall portion comprising a concave second inner surface and a convex second outer surface opposite the second inner surface along a thickness of the second wall portion, an arcuate third wall portion between the first wall portion and the second wall portion, wherein a width of the third wall portion extends between a first side of the third wall portion and an opposite second side of the third wall portion, a first side edge portion, the first side edge portion being proximal to the first side, and a second side edge portion proximate the second side, wherein the second side edge portion is spaced apart from the first side edge portion to define an opening; and a spherical second body connected to the first body via the third wall portion, wherein the length of the second body extends laterally away from the first body, and wherein the implant is capable of transforming between: Expanded state, where: the first wall portion engages a wall of the first blood vessel via the first outer surface, the second wall portion engages the wall of the second blood vessel via the second outer surface, The second body is at least partially disposed within the aneurysm, and the opening is positioned relative to the third blood vessel such that at least some blood flow between the treatment site and the third blood vessel passes through the opening, and A delivery state wherein the first body and the second body are more compact in profile across their respective lengths than in the deployed state.

2. The implant of claim 1, wherein the first body comprises: an arcuate first end edge portion, the arcuate first end edge portion being proximal to the first end; and An arcuate second end edge portion is provided, the arcuate second end edge portion being proximate to the second end.

3. The implant of claim 2, wherein the first side edge portion and the second side edge portion extend continuously from the first end edge portion to the second end edge portion.

4. The implant of claim 1, wherein: The first body comprises: an arcuate first end edge portion proximate to the first end, and an annular second end edge portion proximate the second end; and The first wall portion is tubular.

5. The implant of claim 4, wherein the first side edge portion and the second side edge portion extend continuously from the third wall portion to the first end edge portion.

6. The implant of claim 1, wherein: The first body comprises: an annular first end edge portion proximate to the first end, and an annular second end edge portion proximate the second end; and The first wall portion and the second wall portion are tubular.

7. The implant of claim 1, wherein the implant is capable of transitioning between the delivery state and the unconstrained state, wherein: The second body extends away from the first body in a first direction; The first wall portion extends away from the third wall portion in a second direction that deviates from the first direction by no more than 45 degrees; and The second wall portion extends away from the third wall portion in a third direction that deviates from the first direction by no more than 45 degrees.

8. The implant of claim 1, wherein: The third wall portion defines an arc along a width of the third wall portion between the first side and the second side; and The arc angle of the arc does not exceed 180 degrees.

9. The implant of claim 1, wherein the second body comprises a concave inner surface and a convex outer surface opposite the inner surface of the second body along a thickness of the second body.

10. The implant of claim 1, wherein: The implant defines an annular recess between the first body and the second body; and The annular recess at least partially receives the neck of the aneurysm when the implant is in the expanded state.

11. The implant of claim 1 , wherein: the first body and the second body being connected to each other at a connection point along the length of the first body; a first portion of the length of the first body extending from the connection point to the first end; a second portion of the length of the first body extending from the connection point to the second end; and The first portion of the length of the first body is at least 30% shorter than the second portion of the length of the first body to facilitate sequential deployment of the first wall portion and the second wall portion at the treatment site.

12. The implant of claim 1, wherein: the first body and the second body being connected to each other at a connection point along the length of the first body; a first portion of the length of the first body extending from the connection point to the first end; a second portion of the length of the first body extending from the connection point to the second end; and The first portion of the length of the first body is at least 3 millimeters shorter than the second portion of the length of the first body to facilitate sequential deployment of the first and second wall portions at the treatment site.

13. The implant of claim 1, wherein: The first wall portion, the second wall portion, and the third wall portion include a first mesh; The second body includes a second mesh; and The implant further includes a clamp at which the first mesh and the second mesh are connected to each other.

14. The implant of claim 1, wherein: The second body includes a wall including a concave fourth inner surface and a convex fourth outer surface opposite the fourth inner surface along a thickness of the wall; and The second body engages a wall of the aneurysm via the fourth outer surface when the implant is in the expanded state.

15. A system for treating an aneurysm at a treatment location within the vasculature of a patient, the system comprising: an elongated shaft defining an axial lumen and comprising a proximal end portion and a distal end portion opposite the proximal end portion along the length of the shaft, wherein the shaft is configured to move the distal end portion within a blood vessel toward the treatment location; and An implant in a low-profile delivery state within the lumen, wherein the implant is configured to expand from the delivery state to a deployed state, and wherein the implant comprises: an elongated first body, wherein a length of the first body extends between a first end of the first body and an opposite second end of the first body, and wherein the first body comprises: a first wall portion proximate the first end and extending along a first portion of the length of the first body, a second wall portion proximate the second end and extending along a second portion of the length of the first body, and a third wall portion extending along a third portion of the length of the first body between the first portion and the second portion of the length of the first body, wherein the third wall portion is distal along the length of the shaft to the first wall portion and the second wall portion, and a second body connected to the first body via the third wall portion, wherein the second body is distal to the first body along the length of the shaft, Wherein a distance between the second body and the first end along the length of the axis is at least 3 mm shorter than a distance between the second body and the second end along the length of the axis, so as to facilitate sequential deployment of the first wall portion and the second wall portion at the treatment position.

16. The system of claim 15, wherein the implant is capable of transitioning between the delivery state and the unconstrained state, wherein: The second body extends away from the first body in a first direction; The first wall portion extends away from the third wall portion in a second direction that deviates from the first direction by no more than 45 degrees; and The second wall portion extends longitudinally away from the third wall portion in a third direction that deviates from the first direction by no more than 45 degrees.

17. A method for treating an aneurysm at a treatment location within the vasculature of a patient, wherein a first vessel, a second vessel, and a third vessel converge at the treatment location, the method comprising: positioning a spherical body of the implant within the aneurysm; as well as After positioning the spherical body, positioning the elongated body of the implant within the vasculature outside of the aneurysm, wherein positioning the elongated body comprises: engaging a wall of the first blood vessel via a convex first outer surface of a first wall portion of the elongated body, engaging a wall of the second blood vessel via a convex second outer surface of a second wall portion of the elongated body, engaging a wall of the vasculature between the first blood vessel and the second blood vessel via a convex third outer surface of a third wall portion of the elongated body, the third wall portion comprising a width extending between a first side of the third wall portion and an opposing second side of the third wall portion, wherein the elongated body comprises a first side edge portion proximate the first side and a second side edge portion proximate the second side, and wherein the second side edge portion is spaced apart from the first side edge portion to define an opening, and The opening is positioned relative to the third blood vessel such that at least some blood flow between the treatment site and the third blood vessel passes through the opening.

18. The method of claim 17 further comprising moving the implant toward the treatment position within a blood vessel within an axial lumen of an elongated shaft while the implant is in a low-profile delivery state, wherein positioning the spherical body and the elongated body of the implant comprises causing relative movement between the implant and the shaft to transition the implant from the delivery state toward an expanded, deployed state.

19. The method of claim 18, wherein moving the implant within the blood vessel toward the treatment location comprises moving the implant within the blood vessel toward the treatment location while the third wall portion is distal to the first wall portion and the second wall portion along the length of the axis.

20. The method of claim 19, wherein: The length of the elongated body extends between a first end of the elongated body and an opposite second end of the elongated body; and Moving the implant within the blood vessel toward the treatment location includes moving the implant within the blood vessel toward the treatment location while a distance between the ball-shaped body and the first end along the length of the axis is at least 30% shorter than a distance between the ball-shaped body and the second end along the length of the axis.

21. The method of claim 17, wherein positioning the elongated body comprises at least partially receiving a neck of the aneurysm at an annular recess defined by the implant between the spherical body and the elongated body.

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