Acne-removing essence containing multiple plant extraction components and preparation method of acne-removing essence

Abstract

The invention relates to the technical field of cosmetics, and discloses an acne-removing essence containing multiple plant extraction components, the acne-removing essence comprises the following components: at least one skin conditioner with an anti-inflammatory effect from the root of gentiana australis; the skin conditioner at least contains a parthenocissus parviflora-derived skin conditioner with an inflammation relieving effect; the skin conditioner at least contains a capsicum frutescens fruit source and has the effects of improving skin and resisting irritation; at least one skin conditioner which is derived from cornflower and has the effects of resisting inflammation, resisting oxidation and protecting skin is contained; the skin conditioner at least contains a hyssopus officinalis-derived skin conditioner with the effects of clearing away heat and toxic materials and diminishing inflammation. The preparation method of the acne-removing essence comprises the following steps: pouring the components of the acne-removing essence into a mixing container, and stirring at the temperature of 80-90 DEG C until the components are fully mixed. Compared with the prior art, the acne-removing essence prepared by the invention has the advantages of mild property, no irritation, good detumescence, anti-inflammation, stimulation inhibition and the like.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to an anti-acne essence containing multiple plant extracts and a preparation method thereof. Background Art

[0002] Acne, medically known as acne, is a common skin disease caused mainly by the blockage and inflammation of hair follicles and sebaceous glands. Acne, commonly known as "pimples", is common during adolescence. When hormones in the body stimulate hair growth and sebaceous glands to secrete more oil, hair and sebaceous glands accumulate substances, causing acne on the skin. Although acne is most common among teenagers, adults can also be troubled by acne. Be careful when dealing with acne and avoid squeezing pimples with your hands to avoid causing skin inflammation, redness, swelling, and even scarring.

[0003] At present, the existing acne treatment methods include: microneedle, minimally invasive surgery, gene therapy technology, laser, photon therapy and application of acne-removing cosmetics, etc. Application of acne-removing cosmetics is the most popular method of acne removal as it is more convenient and low-cost. However, the existing acne-removing cosmetics generally have the defects of not being warm enough, irritating to the skin, and easily causing secondary damage to human skin, which needs to be improved. Summary of the invention

[0004] The technical problem to be solved by the present invention is to overcome the above technical difficulties and provide an acne-removing essence containing multiple plant extracts and a preparation method thereof. The prepared acne-removing essence is not only mild and non-irritating, but also has good swelling-reducing, anti-inflammatory, and irritation-inhibiting properties.

[0005] In order to solve the above technical problems, the technical solution provided by the present invention is:

[0006] An anti-acne essence containing multiple plant extracts, the components of the anti-acne essence are as follows:

[0007] Contains at least one skin conditioning agent derived from Gentiana lutea root, which has anti-inflammatory properties;

[0008] Contains at least one skin conditioning agent derived from feverfew that has the ability to reduce inflammation;

[0009] Contains at least one skin conditioning agent derived from capsicum fruit that improves the skin's ability to resist irritation;

[0010] Contains at least one skin conditioning agent from cornflower flower that has anti-inflammatory, antioxidant, and skin-protective properties;

[0011] Contains at least one skin conditioning agent derived from Hyssopus officinalis that has the functions of clearing away heat, detoxifying and reducing inflammation;

[0012] Contains at least one skin conditioning agent with anti-inflammatory properties;

[0013] Contains at least one thickener having a thickening and stabilizing effect;

[0014] Contains at least one preservative with antibacterial effect.

[0015] Furthermore, the first component of the acne essence is the root extract of Gentiana lutea. The root extract of Gentiana lutea is mainly used as a skin conditioner in cosmetics and skin care products. It is relatively safe and can be used with confidence. It generally has no effect on pregnant women. The root extract of Gentiana lutea is not acne-causing. It has a good activation effect on luciferase, indicating that it has an effect on atopic dermatitis and allergies, can inhibit irritation, and has an anti-inflammatory effect; the activation of aromatase shows that it has an effect on the local estrogen level of the skin, and the inhibition and antioxidant properties of elastase have an anti-aging effect; it promotes the secretion of cholesterol in epidermal cells. Cholesterol is an important softening component in human sebum and can improve the state of oily and rough skin. The root extract of Gentiana lutea is suitable for 8 types of skin: sensitive skin, wrinkled skin, non-pigmented skin, oily skin, dry skin, tolerant skin, pigmented skin, and firm skin. One of the skin conditioners derived from the root of Gentiana scabra with anti-inflammatory effect is a Gentiana scabra root extract, which accounts for 3% to 10% of the total weight of the anti-acne essence.

[0016] Furthermore, the second component of the acne-removing essence is a feverfew (CHRYSANTHEMUM PARTHENIUM) extract. In the field of cosmetics, feverfew extract is used as an anti-inflammatory agent and antioxidant, and 27 triterpenoid compounds with anti-inflammatory effects can be separated. These compounds have an inhibitory effect on skin-induced allergies, enhance the resistance of capillaries, inhibit capillary permeability and have anti-inflammatory effects. One of the feverfew-derived skin conditioners with the effect of reducing inflammation is a feverfew extract, which accounts for 5% to 15% of the total weight of the acne-removing essence.

[0017] Further, the third component of the acne essence is CapsICUM FRUTESCENS fruit extract, which is a natural ingredient derived from CapsICUM FRUTESCENS fruit, and has a variety of skin care and beauty effects. Rich in high units of vitamin C, carotene, protein and rich minerals, it is a strong antioxidant that can brighten the skin tone around the eyes, improve the skin's ability to resist irritation, and has a good moisturizing effect. Therefore, it is widely used in skin care products and cosmetics. This ingredient is considered safe and non-acnegenic, so it is suitable for most skin types. In general, CapsICUM FRUTESCENS fruit extract is a natural, safe and effective ingredient that is widely used in skin care products and cosmetics, providing consumers with a variety of skin care and beauty benefits. One of the skin conditioners derived from CapsICUM fruit that improves skin resistance to irritation uses CapsICUM fruit extract, accounting for 5% to 8% of the total weight of the acne essence.

[0018] Furthermore, the fourth component of the acne-removing essence is the flower extract of cornflower (CENTAUREA CYANUS). The flower extract of cornflower is used for a variety of purposes, including but not limited to cosmetics and medicines. The main effects in cosmetics and daily chemical products are anti-oxidation, anti-aging, anti-inflammatory, melanin inhibition, and astringency. Cornflower flower extract can separate 27 triterpenoid compounds with anti-inflammatory effects, which can regulate dermatitis and have an inhibitory effect on induced allergies of the skin; it can enhance the resistance of capillaries, inhibit capillary permeability and have an anti-inflammatory effect; at the same time, it can eliminate free radicals, has antioxidant properties, and has an aging-relieving effect. One of the skin conditioners derived from cornflower flowers, which has anti-inflammatory, antioxidant, and skin protection properties, uses cornflower flower extract, which accounts for 1% to 16% of the total weight of the acne-removing essence.

[0019] Furthermore, the fifth component of the anti-acne essence is HYSSOPUS OFFICINALIS extract. Hyssopus OFFICINALIS and its extracts have been shown to have a variety of biological activities, especially in anti-aging. By measuring the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) related to aging in mouse tissues and serum, as well as the content of lipid peroxide (MDA) and lipofuscin (LPF), the study found that Hyssopus OFFICINALIS and non-volatile extracts can increase the activity of SOD, GSH-Px, and CAT in the body and serum, and can reduce the content of MDA and LPF. This shows that Hyssopus OFFICINALIS extract helps to enhance the antioxidant capacity of the skin and fight free radical damage, thereby possibly delaying the skin aging process. In addition, Hyssopus OFFICINALIS extract also shows moisturizing and soothing effects on the skin, can improve the skin's moisturizing barrier function, reduce water loss, and maintain the skin's moisture balance. This has a positive effect on maintaining skin health and reducing the formation of fine lines and wrinkles. In summary, Hyssop extract has significant anti-aging effects on the skin through its antioxidant and moisturizing properties, helping to maintain the skin's health and reduce signs of skin aging. One of the Hyssop sources has the function of clearing away heat, detoxifying, and reducing inflammation. Hyssop extract is selected, accounting for 1% to 10% of the total weight of the anti-acne essence.

[0020] Furthermore, one of the skin conditioning agents with anti-inflammatory and anti-itching effects is quaternary ammonium salt-73, which accounts for 0.002% to 0.005% of the total weight of the anti-acne essence.

[0021] Furthermore, one of the thickeners with thickening and stabilizing effect is selected from acrylic acid / C10-30 alkyl acrylate cross-linked polymer, accounting for 0.2% to 0.3% of the total weight of the anti-acne essence.

[0022] Furthermore, one of the preservatives with antibacterial effect is o-cymene-5-ol, which accounts for 0.03% to 0.031% of the total weight of the anti-acne essence.

[0023] A method for preparing the acne-removing essence containing multiple plant extracts, the preparation method is as follows:

[0024] Pour the components of the acne-removing essence into a mixing container and stir at 80° C. to 90° C. until fully mixed. Any conventional mixing container equipment known in the art, such as a stirring pot, etc., can be used for preparation.

[0025] The advantages of the present invention compared with the prior art are:

[0026] The acne essence prepared by the present invention is not only mild in nature and non-irritating, but also has good performances such as detumescence, anti-inflammatory, and inhibition of irritation. The main effects of the acne essence include diluting acne pits, facial pits and scars, promoting cell regeneration, inhibiting scar cell proliferation, removing acne epidermal marks, improving shrinkage and uneven holes, and flattening keratin sclerosis scars. The acne essence can also quickly shrink, dry, and disappear acne by dissolving and discharging excess oil and acne dirt, helping the skin to restore health and fineness. These products usually contain a variety of Chinese herbal medicine essences and skin penetration enhancers, which can penetrate into skin cells, kill acne epidermal bacteria, effectively eliminate free radicals, destroy acne cell DNA and interfere with protein synthesis, and achieve acne removal effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is the facial division diagram of the present invention; wherein: 1. forehead area 2. eye area 3. nose area 4. mouth area 5. cheek area.

[0028] Figure 2 It is a test reference flow chart of the present invention. DETAILED DESCRIPTION

[0029] In the description of the present invention, unless otherwise specified, "plurality" means two or more. In addition, the term "include" and any variations thereof are intended to cover non-exclusive inclusions.

[0030] The present invention is further described in detail below in conjunction with the implementation modes and the accompanying drawings.

[0031] Example 1

[0032] The anti-acne essence containing multiple plant extracts is prepared in the following proportions:

[0033]

[0034] Pour the components of the acne-removing essence into a mixing container and stir at 80°C to 90°C until fully mixed.

[0035] Example 2

[0036] The anti-acne essence containing multiple plant extracts is prepared in the following proportions:

[0037]

[0038]

[0039] Pour the components of the acne-removing essence into a mixing container and stir at 80°C to 90°C until fully mixed.

[0040] Example 3

[0041] The anti-acne essence containing multiple plant extracts is prepared in the following proportions:

[0042]

[0043] Pour the components of the acne-removing essence into a mixing container and stir at 80°C to 90°C until fully mixed.

[0044] Acne-removing efficacy test

[0045] Test methods

[0046] 1 Selection of subjects

[0047] Eligible subjects according to the inclusion and exclusion criteria. All subjects voluntarily participated in the test and signed the informed consent before the test.

[0048] 1.1 Selection criteria

[0049] Subjects who meet all of the following criteria will be selected.

[0050] 1.1.1 18 to 45 years old, healthy males or females: The age and gender ratio of the subjects can be determined according to the consumer target described in the instructions for use of the test product.

[0051] 1.1.2 Mild: only acne; or moderate: acne accompanied by inflammatory papules and pustules (Guidelines for the Treatment of Acne in China (2019 Revised Edition)). The number of acne in the entire evaluation area of ​​the subject is not less than 10; the number of papules and pustules on the entire face is not more than 30).

[0052] 1.1.3 Have not received physical / chemical treatments such as photon, blue light, or chemical peeling within 1 month, and have not taken oral or topical corticosteroids, antibiotics, anti-inflammatory drugs, or anti-acne drugs such as retinoic acid.

[0053] 1.1.4 Be able to understand the trial process, voluntarily participate in the trial and sign a written informed consent.

[0054] 1.2 Exclusion criteria

[0055] Those who meet any of the following conditions will be excluded.

[0056] 1.2.1 Pregnant or lactating women

[0057] 1.2.2 Patients with severe acne whose skin lesions are mainly nodules and cysts

[0058] 1.2.3 Have you used cosmetics or other products with acne-removing effects in the past two months?

[0059] 1.2.4 People with highly sensitive constitutions

[0060] 1.2.5 Participated in other human clinical trials of drugs / cosmetics in the past 2 months

[0061] 1.2.6 Volunteers deemed unsuitable for trial participation during clinical evaluation.

[0062] 2 Experimental design

[0063] If a control product is used, qualified subjects can be divided into a test group and a control group according to a random table; or if the acne areas on the left and right sides of the test site are basically symmetrical, a half-face control can be selected, divided into the test product side and the control product side. If a control product is not used, a self-before and after-control test design will be adopted. Clinical evaluation, subject self-evaluation, image capture, and instrument testing will be performed on the test area before and at different times after use (such as 1 week and 2 weeks after use).

[0064] The final number of valid cases completed shall be no less than 30 people / group (side).

[0065] 2.3 Test substances

[0066] 2.3.1 Test products

[0067] Cosmetics that claim to have acne-removing properties.

[0068] 2.3.2 Comparison products

[0069] You can choose a positive control, a negative control, a blank control, or no control.

[0070] 2.3.3 Usage

[0071] If a control product is used, the test product and the control product will be distributed according to the random number table. The subjects will be guided on product use according to the instructions to ensure that the subjects use the product correctly during the trial period. During the trial, the subjects are required to record the use time and any discomfort and adverse reaction symptoms during use.

[0072] 2.4 Test location

[0073] 2.4.1 Clinical evaluation area

[0074] Record the clinical assessment area. For example, if it is the face, divide the face into five areas: forehead, eye, nose, mouth, and cheek. Figure 1 One to five typical lesion areas can be selected as test targets. Acne lesions in the same area should be evaluated at each follow-up visit.

[0075] 2.5 Instruments and Equipment

[0076] 2.5.1 Standard image capture equipment

[0077] VISIA Skin Tester

[0078] Overall assessment: Photo comparison at different follow-up times

[0079] Analysis parameter a value: the number and area ratio of porphyrin

[0080] 2.6 Test Flowchart

[0081] Data analysis

[0082] Table 1 Instrument test results

[0083]

[0084]

[0085] As can be seen from Table 1, the acne-removing essence formula containing multiple plant extracts of the present invention has significant effects on acne and acne marks, and Example 1 is better than Examples 2 and 3. It can be seen that the acne-removing effect increases with the increase in the amount of plant extracts added, so Example 1 is preferred in the present invention.

[0086] The present invention and its embodiments are described above, and such description is not restrictive. If a person skilled in the art is inspired by it and designs an embodiment similar to the technical solution without creativity without departing from the purpose of the invention, it shall fall within the protection scope of the present invention.

Claims

1. An anti-acne essence containing multiple plant extracts, characterized in that: The components of the acne-removing essence are as follows: Contains at least one skin conditioning agent derived from Gentiana lutea root, which has anti-inflammatory properties; Contains at least one skin conditioning agent derived from feverfew that has the ability to reduce inflammation; Contains at least one skin conditioning agent derived from capsicum fruit that improves the skin's ability to resist irritation; Contains at least one skin conditioning agent from cornflower flower that has anti-inflammatory, antioxidant, and skin-protective properties; Contains at least one skin conditioning agent derived from Hyssopus officinalis that has the functions of clearing away heat, detoxifying and reducing inflammation; Contains at least one skin conditioning agent with anti-inflammatory properties; Contains at least one thickener having a thickening and stabilizing effect; Contains at least one preservative with antibacterial effect.

2. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the skin conditioners derived from the root of Gentiana scabra with anti-inflammatory effect is a Gentiana scabra root extract, which accounts for 3% to 10% of the total weight of the anti-acne essence.

3. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the skin conditioners derived from feverfew that has the effect of reducing inflammation is a feverfew extract, which accounts for 5% to 15% of the total weight of the anti-acne essence.

4. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the skin conditioners derived from capsicum fruit that improves the skin's ability to resist irritation is capsicum fruit extract, which accounts for 5% to 8% of the total weight of the anti-acne essence.

5. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the skin conditioners derived from cornflowers, which has anti-inflammatory, antioxidant and skin-protecting effects, is a cornflower extract, which accounts for 1% to 16% of the total weight of the anti-acne essence.

6. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the skin conditioning agents derived from Hyssopus officinalis with the functions of clearing away heat, detoxifying and reducing inflammation is Hyssopus officinalis extract, which accounts for 1% to 10% of the total weight of the anti-acne essence.

7. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the skin conditioning agents with anti-inflammatory and anti-itching effects is quaternary ammonium salt-73, which accounts for 0.002% to 0.005% of the total weight of the anti-acne essence.

8. The acne-removing essence containing multiple plant extracts according to claim 1, characterized in that: One of the thickeners with thickening and stabilizing effect is acrylic acid / C10-30 alkyl acrylate cross-linked polymer, which accounts for 0.2% to 0.3% of the total weight of the anti-acne essence.

9. The anti-acne essence containing multiple plant extracts according to claim 1, characterized in that: One of the preservatives with antibacterial effect is o-cymene-5-ol, which accounts for 0.03% to 0.031% of the total weight of the anti-acne essence.

10. A method for preparing the anti-acne essence containing multiple plant extracts according to any one of claims 1 to 9, characterized in that: The preparation method is as follows: Pour the components of the acne-removing essence into a mixing container and stir at 80°C to 90°C until fully mixed.

Images