Matsolialite preparation for treating waste myasthenia and amyotrophy as well as preparation method and application of Matsolialite preparation for treating waste myasthenia and amyotrophy

Abstract

The invention relates to the technical field of ethnic medicine technologies, in particular to a Matsolialite preparation for treating disuse myasthenia and amyotrophy and a preparation method and application of the Matsolialite preparation for treating disuse myasthenia and amyotrophy. The main materials comprise rhizoma zingiberis, black pepper, white pepper, long pepper, cinnamon, chamomile, radix stephaniae tetrandrae, colchicines, phyllanthus emblica, plumbago zeylanica, rhizoma bletillae, polygonatum odoratum, nymphoides peltatum seeds, antler, frankincense, myristica fragrans, asanrong, galangal, carrot seeds, radix ophiopogonis, fructus terminaliae billericae and milk peaches, and the auxiliary material is honey. The traditional Chinese medicine composition inherits the medication characteristics of traditional Chinese Uygur medicine, is guided by the theory of traditional Chinese medicine, ensures the content of the effective components according to long-term clinical practice, achieves the synergistic effect of the components, improves the bioavailability, has the function of mainly treating various wet-cold or odorless mucus diseases, and has a wide application prospect. The traditional Chinese medicine composition plays a remarkable role in preventing and treating disuse myasthenia and amyotrophy caused by various reasons, and has very important social significance and economic value.

Description

Technical Field

[0001] The invention relates to the technical field of ethnic medicine technology, and is a madituliat agent for treating disuse muscle weakness and muscular atrophy, as well as a preparation method and application thereof. Background Art

[0002] With the aging of the population and the rising incidence of major diseases, the prevalence of disuse syndrome (DS) has increased year by year, becoming a major issue facing clinical medicine and rehabilitation medicine. Disuse syndrome refers to the general term for secondary complications caused by the disuse state, such as long-term bed rest (immobility), immobilization caused by reduced or insufficient activity (inactivity), sensory impairment caused by reduced stimulation, and weightlessness at high altitudes, due to many reasons such as body aging, primary diseases or treatment measures. In the disuse state, the physiological functions of local or systemic organs of the body that do not exercise at all gradually decline. If treatment is not started early, it is very easy to induce myasthenia (myasthenia) and muscle atrophy (MA), leading to a decline in daily living activities (ADL) and quality of life (QOL), and the impact on physical health, medical costs and care burden has attracted widespread attention from the society.

[0003] Disuse muscle weakness is common in neurological disuse. Neuropraxia refers to the state in which the nerve axons and sheaths are intact, but only the motor and sensory nerve conduction functions are forced to be compressed and blocked. It is most common in the state of immobilization disuse caused by compression neuropathy, pressure paralysis and neuromuscular junction lesions. The occurrence and development of muscle weakness are closely related to the body's local or systemic physiological functions and biomechanical balance abnormalities. In the state of disuse, the sensory and motor nerve dysfunction at the cortical and spinal levels of the completely immobile limbs, the gradual decrease in muscle strength and muscle tension, and the decrease in muscle fatigue resistance are very likely to induce muscle weakness if rehabilitation treatment is not carried out early. Studies have shown that the isometric muscle strength of completely immobile limbs can decrease by 1% to 3% per day, 10% to 20% per week, and 50% in 3 to 5 weeks.

[0004] The etiology and pathogenesis of muscle atrophy are very complex and involve multiple aspects. The main causes are changes in muscle morphology (decreased muscle mass, reduced volume, reduced muscle fiber cross-sectional area, and changes in muscle fiber type) and function (decreased muscle strength, muscle tension, and muscle fatigue resistance, and motor nerve sensory and motor dysfunction at the cortical and spinal cord levels), and upregulation of inflammatory mediators.

[0005] Once disuse syndrome is formed, it is difficult to restore the local or systemic physiological functions of the body even with surgery. The rehabilitation of disuse syndrome is a long and arduous task. At present, the treatment of disuse syndrome mainly focuses on single treatment methods for motor function, but its systemic therapeutic effect is very small, and it is difficult to achieve a comprehensive and continuous rehabilitation effect of restoring the body's motor dysfunction, local or systemic physiological function impairment, and perception and cognitive dysfunction at the same time.

[0006] At present, the research on the mechanism of disuse muscle weakness and muscle atrophy is deepening at home and abroad, and therapies such as exercise therapy, physical factor therapy, nutritional therapy, and drug therapy have been proposed one after another. Among them, drug therapy has always been an important means of clinical treatment of muscle weakness and muscle atrophy, which can further enhance the rehabilitation effect of the motor system.

[0007] The Chinese patent document with the publication number CN114617948A discloses a strong made Tuli Ayat preparation and its raw material composition, preparation method and application. The raw material composition of the strong made Tuli Ayat preparation includes active ingredient A, active ingredient B and refined honey; the active ingredient A is composed of the following components: 30 parts of dried ginger, 30 parts of pepper, 30 parts of longan, 30 parts of cinnamon, 30 parts of emblica, 30 parts of hairy terminalia flesh, 30 parts of plumbaginous danshen, 30 parts of fangji, 30 parts of central Asian white ginseng, 30 parts of milk peach, 30 parts of white pine nut kernel, 30 parts of chamomile, and 15 parts of chamomile seeds; the active ingredient B is 60-120 parts of raisin fluid extract; the strong made Tuli Ayat preparation is honey paste or honey pill.

[0008] The Chinese patent document with publication number CN1785223A provides a drug and its preparation method for treating muscle atrophy and myasthenia gravis caused by motor neuron diseases (amyotrophic lateral sclerosis, progressive spinal muscular atrophy, progressive bulbar palsy, primary lateral sclerosis), progressive muscular dystrophy, congenital myopathy and other diseases, so as to achieve both symptomatic and root treatment. The drug is prepared from raw materials ginseng and epimedium.

[0009] The Chinese patent document with the publication number CN1526440A discloses a Chinese medicine compound preparation for treating muscular atrophy and weakness - paralysis and its preparation method. The characteristics are as follows: the formula is based on 100% of the raw materials by weight, including 2.5-25% of Tianma, 5-25% of whole worm, 1-15% of centipede (without legs), 4-15% of earthworm, 1-10% of Achyranthes bidentata, 1-15% of Chuanduan, and 3-15% of Eucommia ulmoides carbon. If the patient is seriously ill and weak, the formula is based on 100% of the raw materials, including 2.3-30% of Tianma, 5-30% of whole scorpion, and 15-50% of centipede (without legs).

[0010] The Chinese patent document with publication number CN112057501A discloses a Chinese medicine composition, a Chinese medicine ointment and an external hot compress plaster for treating muscle atrophy and muscle weakness, belonging to the field of medical technology. The Chinese medicine composition of the present invention comprises the following components by weight: 8-12 parts of ginseng, 28-32 parts of astragalus, 14-16 parts of cistanche, 8-12 parts of atractylodes, 8-12 parts of tuckahoe, 8-12 parts of licorice, and 8-12 parts of rhodiola.

[0011] The above patent literature reports show that in the field of rehabilitation medicine and clinical medicine, the types of components of existing myasthenia gravis and muscular atrophy drugs are few, the efficacy of multiple organ dysfunction is not obvious, and the applicable diseases are limited. The systemic multiple organ dysfunction of patients with disuse myasthenia gravis and muscular atrophy syndrome caused by various reasons cannot achieve the purpose of targeted and systemic effective internal treatment.

[0012] Chinese Uygur traditional medicine is an important part of the traditional medicine of the motherland. It has a unique theoretical system and treatment methods, especially in the treatment of disuse syndrome. Humoral pathology (humor theory) is the core of the basic theory of Chinese Uygur traditional medicine. According to the humor theory, disuse muscle weakness and muscle atrophy are mainly caused by the tasteless mucus in the abnormal mucus syndrome, which causes the excessively thin mucus to fill the muscles and tendons, relax the tendons and muscles, and affect the muscle function and morphological structure.

[0013] According to the Chinese Uygur traditional medicine compatibility method, developed from my country's traditional Chinese herbal medicine and ethnic herbs for the treatment and prevention of disuse muscle weakness and muscular atrophy, Madetuliat Mi ointment or pills have the special effects of promoting blood circulation and removing blood stasis, improving blood circulation throughout the body, clearing abnormal tasteless mucus, opening up mucous blockages, dispelling cold and drying dampness, nourishing the dominant organs (heart, brain, kidney, liver, stomach), promoting dryness and heat, warming up and strengthening yang, strengthening tendons and muscles, strengthening bones, astringing and growing muscles, nourishing nerves, nourishing the brain, strengthening the brain and improving intelligence, dispelling cold and relieving pain, digesting food and stimulating appetite, ventilating and removing bloating, softening and reducing swelling, dispersing qi and reducing inflammation, removing putrefaction and generating brightness, nourishing the kidney and strengthening yang, consolidating essence and promoting hair growth, nourishing blood and nourishing hair, unblocking and relieving pain, enhancing pigmentation, dispelling wind and relieving itching, etc. It is mainly used to treat various diseases of dampness, cold or mucous nature, and has very important social significance and economic value. Summary of the invention

[0014] The present invention provides a madituliat agent for treating disuse myasthenia and muscular atrophy, as well as a preparation method and application thereof, which overcomes the deficiencies of the above-mentioned prior art and can effectively solve the problems of the existing myasthenia and muscular atrophy drugs, such as the small number of component types, the unobvious efficacy of multiple organ functions, the limited adaptability to the diseases, and the inability to effectively treat the diseases in a targeted and systemic manner.

[0015] One of the technical schemes of the present invention is achieved by the following measures: a madituliayat agent for treating disuse muscle weakness and muscular atrophy, wherein the raw materials include main ingredients and auxiliary ingredients, and the main ingredients include 45 to 50 parts of dried ginger, 35 to 40 parts of black pepper, 35 to 40 parts of white pepper, 35 to 40 parts of longan, 35 to 40 parts of cinnamon, 35 to 40 parts of chamomile, 35 to 40 parts of African stephania root, 15 to 20 parts of colchicum, 35 to 40 parts of emblica fruit, 35 to 40 parts of plumbaginous plant, 35 to 40 parts of Bletilla striata, 30 parts of celery root ... 5 to 40 parts, 35 to 40 parts of European Polygonatum, 35 to 40 parts of Nymphoides dulcis seeds, 15 to 20 parts of deer horn, 35 to 40 parts of frankincense, 35 to 40 parts of nutmeg, 15 to 20 parts of asaron, 15 to 20 parts of galangal, 15 to 20 parts of carrot seeds, 15 to 20 parts of Ophiopogon japonicus, 35 to 40 parts of Terminalia chebula flesh, and 35 to 40 parts of milk peach. The auxiliary material is honey. The Madituliaiyat agent for treating disuse myasthenia and muscular atrophy includes Madituliaiyat honey paste and Madituliaiyat pills according to the dosage form.

[0016] The following is a further optimization and / or improvement of one of the above-mentioned technical solutions: The above-mentioned Madetulyaiat honey paste is prepared according to the following steps: S1, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S2, heating the honey after removing impurities to obtain refined honey for later use; S3, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain the Made Tuli Ayat honey paste.

[0017] In the above step S3, 100 g of mixed medicinal powder is added to every 300 g of refined honey.

[0018] The above-mentioned Madetuly Ayat pills are prepared according to the following steps: S11, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S12, heating the honey from which impurities have been removed to obtain refined honey for later use; S13, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain Madetuliayat pills.

[0019] In the above step S13, 100 g of mixed medicinal powder is added to every 50 g of refined honey.

[0020] The second technical solution of the present invention is achieved by the following measures: a preparation method of a madutli ayat agent for treating disuse muscle weakness and muscle atrophy, wherein the madutli ayat honey paste is prepared according to the following steps: S1, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S2, heating the honey after removing impurities to obtain refined honey for later use; S3, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain the Made Tuli Ayat honey paste.

[0021] The following is a further optimization and / or improvement of the second technical solution of the above invention: In the above step S3, 100 g of mixed medicinal powder is added to every 300 g of refined honey.

[0022] The above-mentioned Madetuly Ayat pills are prepared according to the following steps: S11, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S12, heating the honey from which impurities have been removed to obtain refined honey for later use; S13, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain Madetuliayat pills.

[0023] In the above step S13, 100 g of mixed medicinal powder is added to every 50 g of refined honey.

[0024] The third technical solution of the present invention is achieved through the following measures: the use of a madituliat agent for treating disuse muscle weakness and muscular atrophy in the preparation of drugs for preventing, treating and / or treating disuse muscle weakness and muscular atrophy.

[0025] The invention inherits the medication characteristics of traditional Chinese Uygur medicine, takes traditional Chinese medicine theory as guidance, and based on long-term clinical practice, ensures the content of effective components, and the components play a synergistic role, thereby improving the bioavailability. It has the function of treating various diseases of dampness, coldness or abnormal tasteless mucus, plays a significant role in preventing and treating disuse muscle weakness and muscle atrophy caused by various reasons, and has very important social significance and economic value. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Attached Figure 1 The present invention is a flow chart of the preparation process of the Madituliat agent for treating disuse muscle weakness and muscular atrophy. DETAILED DESCRIPTION

[0027] The present invention is not limited by the following embodiments, and specific implementation methods can be determined according to the technical scheme of the present invention and actual conditions. Unless otherwise specified, the various chemical reagents and chemicals mentioned in the present invention are all known and commonly used chemical reagents and chemicals in the prior art.

[0028] The present invention will be further described below in conjunction with embodiments: Embodiment 1: The madituliaot agent for treating disuse muscle weakness and muscular atrophy is characterized in that the raw materials include main ingredients and auxiliary ingredients. The main ingredients, measured by weight, include 45 to 50 parts of dried ginger, 35 to 40 parts of black pepper, 35 to 40 parts of white pepper, 35 to 40 parts of longan, 35 to 40 parts of cinnamon, 35 to 40 parts of chamomile, 35 to 40 parts of African stephania roots, 15 to 20 parts of colchicum, 35 to 40 parts of emblica fruit, 35 to 40 parts of plumbaginous plant, 35 to 40 parts of Bletilla striata, 35 to 40 parts of Polygonatum odoratum, 35 to 40 parts of Nymphoides oleifera seeds, 15 to 20 parts of Deer Horn, 35 to 40 parts of Frankincense, 35 to 40 parts of Nutmeg, 15 to 20 parts of Asaron, 15 to 20 parts of Alpinia officinalis, 15 to 20 parts of Carrot seeds, 15 to 20 parts of Ophiopogon japonicus, 35 to 40 parts of Terminalia chebula flesh, 35 to 40 parts of Prunus mume, and the auxiliary material is honey. The Madituliat agent for treating disuse myasthenia and muscular atrophy includes Madituliat honey paste and Madituliat pills according to the dosage form.

[0029] Embodiment 2: The madituliat agent for treating disuse muscle weakness and muscular atrophy is characterized in that the raw materials include main ingredients and auxiliary ingredients. The main ingredients, measured by weight, include 45 or 50 parts of dried ginger, 35 or 40 parts of black pepper, 35 or 40 parts of white pepper, 35 or 40 parts of longan, 35 or 40 parts of cinnamon, 35 or 40 parts of chamomile, 35 or 40 parts of African stephania roots, 15 or 20 parts of colchicum, 35 or 40 parts of emblica fruit, 35 or 40 parts of plumbaginous flower, 35 or 40 parts of Bletilla striata, 35 or 40 parts of Polygonatum odoratum, 35 or 40 parts of Nymphoides oleifera seeds, 15 or 20 parts of Deer Horn, 35 or 40 parts of Frankincense, 35 or 40 parts of Nutmeg, 15 or 20 parts of Asaron, 15 or 20 parts of Alpinia officinalis, 15 or 20 parts of Carrot seeds, 15 or 20 parts of Ophiopogon japonicus, 35 or 40 parts of Terminalia chebula flesh, 35 or 40 parts of Prunus mume, and the auxiliary material is honey. The Madituliat agent for treating disuse myasthenia and muscular atrophy includes Madituliat honey paste and Madituliat pills according to the dosage form.

[0030] In the present invention, according to the principles of Chinese (Uyghur) medicine formula, the functional characteristics of each Chinese medicine are as follows: Dried ginger: Local names include Zangibili and Akchasika, which is the rhizome of Zingiber officinale Rosc, a plant of the ginger family. This product is secondary dry and hot in nature, pungent in taste, and has the functions of warming the middle, dispelling cold, restoring yang, unblocking meridians, drying dampness and eliminating phlegm. It is mainly used to treat cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, phlegm and cough.

[0031] Black pepper: The local name is Karamuqi, also known as Pilipiliaisiwaid and Murjisiya. It is the dried nearly mature fruit of PipernigrumL, a plant of the Piperaceae family. This product is dry and hot in nature and spicy in taste. It has the functions of drying and generating heat, promoting digestion and appetite, ventilating and removing bloating, relieving cough and reducing phlegm, nourishing the brain and relieving pain. It is mainly used to treat damp-cold or mucous diseases, such as stomach cold and poor appetite, indigestion, abdominal distension, cough and phlegm, headache due to brain deficiency, toothache, etc.

[0032] White pepper: The local medicine is called Akemuqi, also known as Pilipili, Aibiyezi, and Murjijisaifeide. It is the dried nearly mature fruit of Pipernigrum, a plant of the Piperaceae family. The nature, taste, function, and indications of white pepper and black pepper are basically the same. This product is dry and hot in nature, pungent in taste, and has the functions of drying and generating heat, promoting digestion and appetizing, ventilating and removing bloating, relieving cough and reducing phlegm, nourishing the brain and relieving pain. It is mainly used to treat damp-cold or mucous diseases, such as stomach cold and poor appetite, indigestion, abdominal distension, cough and phlegm, headache due to brain deficiency, and toothache.

[0033] Piper longum: The local medicine is called Pilipili, also known as Feilifeili Darez and Darifilifeili, which is the dried immature fruit spike of Piper longum L. This product is dry and hot in nature and pungent in taste. It has the functions of generating heat, nourishing the stomach and digesting food, ventilating and removing bloating, replenishing essence and strengthening yang, promoting urination and menstruation, relieving cough and reducing phlegm, dispelling cold and relieving pain. It is mainly used to treat damp-cold or mucous diseases, such as poor appetite due to stomach deficiency, abdominal distension and pain, lack of essence and impotence, urinary obstruction, irregular menstruation, cough and phlegm, and pain in large and small joints.

[0034] Cinnamon: Local medicine name: Kelindazhiqini, alias: Sailihe. It is the old bark of CinnamomumcassiaPresl., a plant of Lauraceae. This product has a secondary dry heat property, fragrant and spicy. It has the functions of generating heat, regulating abnormal mucus, dispelling cold and nourishing the heart, warming the middle and stimulating the appetite, drying dampness and stopping diarrhea, and promoting urination and menstruation. It is mainly used to treat damp-cold or mucus-type heart and gastrointestinal diseases, such as cold palpitations, panic, poor appetite, abdominal distension and diarrhea, indigestion, amenorrhea, etc.

[0035] Chamomile: The local medicine is called Babu Nai, also known as Babu Nai Ji, which is the dried whole herb of Matricariachamomilla L. This product is secondary dry and hot in nature, bitter in taste, and has the functions of generating heat, softening and reducing swelling, warming the stomach and stimulating appetite, promoting digestion, dispersing qi and relieving inflammation, strengthening the brain and tendons, dispelling wind and relieving pain, and promoting diuresis and menstruation. It is mainly used to treat damp-cold or mucous diseases, such as various damp-cold lumps and swellings, joint swelling and pain, stomach deficiency and poor appetite, indigestion, abdominal distension, muscle relaxation, amenorrhea, and urinary retention.

[0036] African Stephania root: also known as Aristolochia, local medicine name Muhas, alias Maidailai Keri, is the root of Jateorhizacolumba Miers, a plant of the Menispermaceae family. This product is dry and hot in nature, slightly bitter in taste, and has the functions of generating heat, dispelling cold and dampness, dispersing qi and relieving pain, strengthening tendons and replenishing spirit, nourishing the body and replenishing essence, and relieving inflammation and diarrhea. It is mainly used to treat damp-cold or mucous diseases, such as back pain, joint pain, tendon and muscle weakness, muscle relaxation, epilepsy, neurasthenia, thin body and less essence, enteritis and diarrhea, etc.

[0037] Colchicine: Local medicine name: Su Renjiang. It is the dried bulb of Colchium autumnale L., a plant of the Liliaceae family. This product is dry and hot in nature and bitter in taste. It has the functions of generating heat, dispelling wind and relieving pain, reducing inflammation and swelling, clearing obstructions and removing jaundice, removing cold and boosting yang. It is mainly used to treat damp-cold or mucous diseases, such as arthritis, rheumatism, rheumatoid arthritis, jaundice, damp-cold impotence, etc.

[0038] Phyllanthus emblica: Also known as Phyllanthus emblica peel, Ammole, local medicine name Amilposi, alias Kexiruli Amilage, is the dried peel of Phyllanthus embolic L., a plant of the Euphorbiaceae family. This product is secondary dry and cold in nature, slightly sour in taste, and has the functions of activating dryness and coldness, purifying abnormal blood quality, replenishing the main organs (brain, heart, liver, kidney), enhancing the retention of the stomach, removing body fluid foul air, enhancing vision, strengthening hair, drying dampness and stopping diarrhea, clearing heat and quenching thirst, etc. It is mainly used to treat damp-heat or blood quality diseases and general weakness, such as brain deficiency, palpitations, stomach deficiency, neurasthenia, weak eyesight, hair loss, diarrhea and thirst, etc.

[0039] Plumbago: The local medicine is called Xietiranji, also known as Bihebairande and Qitai. It is the whole herb and root of the Plumbago Plulmbagozeylanis L. This product is dry and hot in nature, bitter and astringent in taste, and has the functions of generating heat, removing cold and dampness, causing redness and blistering of the skin, increasing pigment, dispersing qi and relieving pain, removing wind and relieving itching, removing rot and generating brightness, clearing voice and relieving throat, etc. It is mainly used to treat damp-cold or mucous diseases, such as leukoplakia, vitiligo, paralysis, facial paralysis, joint pain, back pain, skin itching, various eczemas, and aphonia due to excessive cold.

[0040] Central Asian Bletilla: Also known as European Bletilla, European Bletilla, local medicine name Sulaifu, alias Sulaibi Misri, Husyetus Sulaibi, is the dried tuber of the orchid plants OrchismorioL, OrchismasculaL, OrchismasculataL or OrchischloranthaGust PlatantherachloranthaGustexRchbP. This product is first-class damp-heat in nature, with the functions of generating dampness and heat, warming the kidney and strengthening yang, replenishing essence and fattening the body, nourishing the main organs (brain, heart, liver, kidney), strengthening tendons and muscles, consolidating essence and promoting hair growth, replenishing blood and nourishing hair, etc. It is mainly used to treat dry and cold or black bile diseases, such as waist cold impotence, less sperm and thin body, brain deficiency and forgetfulness, heart ache and panic, liver deficiency and less blood, spermatorrhea and premature ejaculation, spermatorrhea and weak body, hair loss and gray hair, etc.

[0041] Polygonatum officinale: Local medicine name Shakakuli, alias Jiezaierdaixiti. It is the rhizome of Polygonatum officinale All. of the Liliaceae family. The original plant is distributed in Northeast my country, and in Central Asia, the Mediterranean, Western Europe, Egypt and other places in Africa. This product is hot and moist in nature, slightly sweet in taste, and has the functions of removing moisture and heat, nourishing the body and strengthening yang, nourishing the body and replenishing essence, consolidating essence and promoting lactation, lowering blood sugar and quenching thirst. It is mainly used to treat dry and cold or black bile diseases, such as physical weakness and impotence, thin body and less sperm, premature ejaculation and spermatorrhea, milk retention, urine sugar and thirst.

[0042] Lepidium apetalum seeds: Lepidium apetalum seeds, also known as glandular stem Lepidium apetalum seeds, local medicine name Tudi Ri. It is the dried mature seeds of the cruciferous plant Lepidium apetalum Willd. This product is secondary dry and hot in nature and pungent in taste. It has the functions of generating heat, replenishing essence and consolidating essence, strengthening yang, promoting lactation, enhancing vision, reducing inflammation and swelling, etc. It is mainly used to treat damp-cold or mucous diseases, such as rare semen, premature ejaculation, impotence, insufficient milk, decreased vision, various inflammations and swellings, etc.

[0043] Deer antler: This product is secondary dry and hot in nature and salty in taste. It has the functions of generating heat, nourishing the kidney and strengthening yang, stimulating sexual desire, consolidating essence and replenishing essence, relieving asthma and cough, nourishing the stomach and intestines, appetizing and digesting food, promoting diuresis and reducing swelling, strengthening tendons and bones, relieving pain, enhancing pigmentation, dispelling wind and relieving itching. It is mainly used to treat damp-cold or mucous diseases, such as impotence due to kidney cold, low libido, premature ejaculation and spermatorrhea, asthma and cough, stomach deficiency and poor appetite, indigestion, intestinal ulcer, intestinal obstruction, various edema, relaxation of tendons and bones, infertility due to uterine cold, lack of menstruation, lack of milk, cold toothache, cold pain in the flanks, vitiligo, and skin itching.

[0044] Frankincense: Also known as nipple incense, local medicine name Kunduer, another name Kundu Rusi, is the oil gum resin exuded from the skin of Boswellia carterii Birdw. and plants of the same genus in the olive family after being cut. This product is dry and hot at the first level, pungent and bitter in taste, has the functions of dryness and heat, memory enhancement, asthma and cough relief, astringency and muscle growth, stomach tonification and digestion, etc. It is mainly used to treat damp-cold or mucus-type brain diseases, such as damp brain deficiency, memory loss, cold asthma, short cough, bronchial dilatation, various sores, stomach weakness, indigestion and other symptoms.

[0045] Nutmeg: The local medicine is called Zhuyouzi, and its other names are Jieweizi Baiwa and Jieweizi Boya. It is the seed of the plant Myristica fragrans Houtt. of the Myristicaceae family. This product is dry and hot in nature, sweet in taste and fragrant in smell. It has the functions of pleasing the heart, moistening body fluids, digesting food, maintaining body temperature, strengthening the stomach, eliminating esophagitis, strengthening the liver, increasing the wetness, improving sexual desire, removing liver and spleen sclerosis and cold inflammation, aromatic oral cavity, moisturizing the skin, reducing urine odor, dispelling wind, removing black spots and freckles, etc. It is mainly used to treat dizziness, jaundice, vomiting, stomach cold and dampness, damp-cold diarrhea, stomach filth and dampness, eliminating edema, and promoting diuresis.

[0046] Asarong: Also known as European asarum, the local medicine name is Asarong, and the aliases are Muxi Kebala and Tai Geer. It is the dried rhizome of the Aristolochiaceae plant AsarumeuropaeumL. This product is secondary dry and hot in nature, pungent and strong in taste. It has the functions of generating dryness and heat, opening liver obstruction, diuresis and swelling, nourishing the brain and opening the orifices, drying dampness and dispersing cold, nourishing tendons and relieving tightness, and dredges menstruation and relieves pain. It is mainly used to treat damp-cold or mucous diseases, such as hepatomegaly, general edema, jaundice, epilepsy, facial paralysis, paralysis, stiffness of hands and feet, paralysis of limbs, urine retention, amenorrhea, joint pain, etc.

[0047] Alpinia officinarum Hance: The local medicine is called Keqike Hulinjiang, which is the dried rhizome of Alpinia officinarum Hance, a plant of the ginger family. This product is dry and hot in nature, pungent in taste, and has the functions of generating heat, expelling cold and dampness, warming the stomach and digesting food, dispersing qi and relieving pain, opening blockages, strengthening the kidney and waist, replenishing essence and strengthening yang, etc. It is mainly used to treat various diseases of damp-cold body fluids or mucus, such as weakness of the stomach, soreness of the abdomen, cold pain in the waist and legs, intestinal obstruction, and impotence due to lack of essence.

[0048] Carrot seeds: The local medicine name is Saiweiziou Ruhe, and its aliases are Baizurulijiezaier and Tuhumigaizaier. It is the dried mature seeds of the wild carrot DaucuscarotaLvarsativaDC of the Umbelliferae family. This product is damp and hot in nature, pungent in taste, and has the functions of generating dampness and heat, promoting diuresis and relieving stranguria, dispelling cold and relieving menstruation, regulating menstrual fluid, and dissolving stones. It is mainly used to treat dry and cold or black bile diseases, such as urinary retention, urinary incontinence, amenorrhea, menstrual obstruction, kidney stones, bladder stones, etc.

[0049] Ophiopogon japonicus: This product is the dry root of Ophiopogon japonicus (Thunb.) Ker-Gawl, a plant of the Liliaceae family. It is also known as Ophiopogon japonicus and Wheat Asparagus. It has the functions of nourishing yin, promoting body fluid, moistening the lungs and clearing the heart. It is mainly used to treat dry cough due to lung dryness, cough due to consumptive disease, thirst due to loss of body fluid, restlessness and insomnia, internal heat and thirst, dry intestines and constipation, and pharyngeal diphtheria.

[0050] Terminalia bellirica Roxb: The local medicine name is Bailile Posi, also known as Kexiruli Baililaiji and Positi Baiyire. It is the dried fruit of Terminalia bellirica Roxb. This product has the functions of dryness and coldness, purifying abnormal blood and clearing bile, stopping diarrhea, strengthening the brain, improving eyesight, and nourishing the stomach and intestines. It is mainly used to treat damp-heat or blood diseases, such as stomach and intestinal diarrhea, weak vision, tears in the wind, and weak stomach and intestines.

[0051] Milk peach: Also known as coconut, local medicine name is Naerjili, alias Jieweiziyindi, is the mature fruit of the palm plant coconut tree CocosnuciferaL. This product is secondary damp-heat in nature, sweet in taste, has the functions of generating dampness and heat, enhancing natural heat in the body, generating blood and fattening the body, warming the kidney and filling essence, nourishing the brain and improving eyesight, protecting the fetus and nurturing the fetus, and expelling intestinal worms. It is mainly used to treat dry cold or black bile diseases, such as cold paralysis, muscle relaxation, mental illness, depression, dry anemia and thin body, kidney deficiency and lack of essence, brain deficiency and weak eyesight, fetal restlessness, intestinal worms, etc.

[0052] Example 3: As an optimization of the above example, the Madetuly Ayat honey paste is prepared according to the following steps: S1, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S2, heating the honey after removing impurities to obtain refined honey for later use; S3, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain the Made Tuli Ayat honey paste.

[0053] Example 4: As an optimization of the above example, in step S3, 100 g of mixed medicinal powder is added to every 300 g of refined honey.

[0054] Example 5: As an optimization of the above example, Madetulyaiat pills were prepared according to the following steps: S11, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S12, heating the honey from which impurities have been removed to obtain refined honey for later use; S13, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain Madetuliayat pills.

[0055] Example 6: As an optimization of the above example, in step S13, 100 g of mixed medicinal powder is added to every 50 g of refined honey.

[0056] Example 7: The Madetulyaiat honey paste is prepared according to the following steps: S1, clean and dry the raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach, select and grind frankincense, prepare to mix and obtain mixed medicinal powder, and set aside, The specific steps are as follows: (1) Cleaning and selection of medicinal materials: Remove the outer packaging of the raw medicinal materials and frankincense to be selected, pour them out, and place them on the medicinal material cleaning workbench for selection to remove impurities and non-medicinal debris. Put the cleaned medicinal materials into the material barrel, weigh them, and affix material labels; (2) Cleaning of medicinal materials: Put the raw medicinal materials to be cleaned into the medicine washing machine, start the spray water, start the drum of the medicine washing machine, and put the medicinal materials into the material basket after cleaning; then proceed to the next process; (3) Drying of medicinal materials: Spread the raw medicinal materials evenly on trays (thickness of trays: 2 cm to 3 cm), and place them in a vacuum sterilization drying oven for drying. The drying temperature is 60°C to 70°C, and the drying time is 4 to 5 hours. (4) Crushing and screening: Collect the clean medicinal materials such as dried ginger, black pepper, longan, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbagin, bletilla striata, polygonatum, water chestnut seed, antler, nutmeg, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp, and coconut peel according to the batch preparation instructions, install a 100-mesh sieve on the universal grinder, turn on the machine to mix and crush, grind frankincense separately (the vortex oscillating sieve has a mesh size of 80 mesh), put them into barrels lined with plastic bags, tie the bags, weigh and check, calculate the material balance, fill in the preparation records and material labels, and set aside; (5) Weighing and preparing clean medicinal materials: accurately weigh 50g of dried ginger, 40g of black pepper, 40g of Piper longum, 40g of cinnamon, 40g of chamomile, 40g of African stephania root, 20g of colchicum, 40g of emblica fruit, 40g of plumbagin, 40g of Bletilla striata, 40g of Polygonatum odoratum, 40g of Nymphoides edulis seed, 20g of antler, 40g of frankincense, 40g of nutmeg, 20g of galangal, 20g of carrot seed, 20g of Ophiopogon japonicus, 40g of Terminalia chebula flesh, 40g of milk peach, etc., and put them into clean and dry stainless steel barrels, affix material labels, and set aside; then proceed to the next process; 6) Total mixing: Take the mixed powder and put it in the V-type mixer, turn on the machine, and mix for 20 minutes. Put the mixed powder in a clean and dry container lined with a plastic bag, fill in the material label and configuration record, and send the mixed powder to the pill making room; S2, heating the honey after removing impurities to obtain refined honey for later use, wherein the specific steps of refining honey are as follows: Collect honey according to the batch preparation instructions. Before refining, filter out impurities, dead bees, pollen and other foreign matter. Add the honey with impurities removed into the sandwich pot and start heating and refining the honey. The temperature is controlled at 116℃ to 118℃. Refine for 0.5 hour to 1 hour until the relative density of the honey is 1.35 to 1.37. Move it to the warm honey tank (temperature controlled at 70℃ to 80℃), fill in the material label and preparation record, and keep it for use; then proceed to the next process; S3, adding the mixed medicinal powder to the refined honey, mixing and lumping together, and obtaining the Made Tuli Ayat honey paste, wherein the specific steps are as follows: Stir the mixed powder obtained in step S1 for 10 minutes, add 300 g of refined honey for every 100 g of mixed powder in a ratio of 1:3, put it into a mixer and mix it for 15 minutes to make the honey lump moderate in hardness and uniform in color, pour the honey lump into a clean container and fill it to obtain the Made Tuli Ayat honey paste.

[0057] Example 8: The preparation method of the Madetuliat pills is different from the preparation method of the Madetuliat honey paste in Example 7 in that 50 g of refined honey is added to every 100 g of mixed medicinal powder, and the remaining steps are the same, wherein the honey lump is poured into a pill-making machine (add frequently and in small amounts), and pills are made according to the standard operating procedures of the pill-making machine (the pill weight is controlled at 0.3 g to 0.32 g), dried, selected pills are polished with sesame oil (sieve 7.8 mm to 8.2 mm, moisture 8 to 12), the prepared honey pills are placed in a clean plate, and packaged to obtain the Madetuliat pills.

[0058] The process flow chart of the preparation of the madituliayat agent for treating disuse-related myasthenia and muscular atrophy of the present invention is as follows: Figure 1 shown.

[0059] The beneficial effects of the present invention are as follows: (1) Each herb in the prescription is carefully selected after clinical demonstration by famous local Chinese medicine and ethnic medicine experts. It organically combines 24 natural medicines used in traditional medicine for the treatment of disuse myasthenia and muscular atrophy, giving full play to the combined effect of Chinese medicine. The medicine is safe and convenient to use, suitable for many diseases, with a wide range of uses, fast effect, definite efficacy, long-lasting and reliable efficacy, low price and high patient compliance; (2) The present invention has no side effects, no drug resistance and no physical dependence; (3) The preparation process is simple, the cost is low, and it has certain market competitiveness; (4) The source of medicinal materials is abundant, the quality can be guaranteed, and it is suitable for large-scale industrial production.

[0060] Animal experiments and clinical experiments were conducted on the madituliayat agent for treating disuse myasthenia and muscular atrophy of the present invention. 1. Animal Experiments (1) Materials (1.1) Experimental materials: carotid artery rubber cannula (inner diameter 0.3 mm, length 2.5 mm) and other experimental materials.

[0061] (1.2) Experimental drugs (1.2.1) Traditional Chinese Uyghur medicine: Madetuli Ayatmi paste (Example 7). The rat gavage volume was 1 ml / 100 g, once a day. The rat efficacy experiment was performed according to the body surface area conversion. The rat dosage was calculated based on the daily dosage of an adult (60 kg) (10 g per day, twice a day), with a low-dose group of 1.05 g / kg, a medium-dose group of 2.10 g / kg, and a high-dose group of 4.20 g / kg.

[0062] (1.2.2) Positive oral control drug: Methylcobalamin tablets. Manufacturer: Eisai (China) Pharmaceutical Co., Ltd. National medicine approval number: H20030812, specification: 10 tablets / plate * 2 plates / box. The dosage of methylcobalamin for rats is calculated according to the daily dosage of adults (60kg), that is, 0.016mg / 1ml; the dosage of the drug Mader Tuli Ayat for rats of the present invention is 0.008mg / 1ml for the low-dose group, 0.016mg / 1ml for the medium-dose group, and 0.032g / kg for the high-dose group.

[0063] (1.3) Experimental animals SD (Sparague-Dawley) rats, male, weighing 200 ± 20 g, were provided by the Animal Experiment Center of Xinjiang Medical University, ordinary grade animals, license: SYXK (New) 2018-0002, SCXK (New) 2018-0001. After the experimental animals were purchased, they were adapted to feeding in the SPF environment of the animal room of the Animal Experiment Center of Xinjiang Medical University for 1 week, with a laboratory temperature of 25° and a humidity of 60%.

[0064] (2) Experimental methods Healthy and clean SD male rats were selected and divided into 8 groups: sham operation group, model control group, positive control group, low-dose Chinese medicine group, medium-dose Chinese medicine group, high-dose Chinese medicine group, basic stimulation rehabilitation treatment group, basic stimulation rehabilitation treatment + high-dose Chinese medicine group. The chronic sciatic nerve compression injury model designed by Mackinnon was used to replicate the rat model of disuse injury caused by chronic peripheral nerve compression required for this project (during the modeling surgery, the sham operation group was not ligated after the cannula, and the other steps were the same for the 8 groups). After waking up, continue to feed with ordinary feed for 6 weeks. After successful modeling, one rat was selected from each group for pre-intervention index detection, and the other rats continued to be fed with ordinary feed and implemented for 6 weeks, as follows: sham operation group (distilled water gavage, n=6), model control group (distilled water gavage, n=5), positive control group (methylcobalamin tablet gavage, n=7), low-dose Chinese medicine group (small-dose Madituli Ayate Mi paste gavage, n=7), medium-dose Chinese medicine group (medium-dose Madituli Ayate Mi paste gavage, n=5), high-dose Chinese medicine group (high-dose Madituli Ayate gavage, n=7), basic stimulation rehabilitation treatment group (distilled water gavage + basic stimulation rehabilitation nursing treatment, n=5), basic stimulation rehabilitation treatment + high-dose Chinese medicine group (basic stimulation rehabilitation treatment + high-dose Madituli Ayate gavage, n=6). Evaluation indicators were tested after 6 weeks of intervention.

[0065] Basic stimulation rehabilitation therapy includes: transcutaneous stimulation therapy, hemibody stimulation therapy, micro-vibration stimulation therapy, balance stimulation therapy, and treadmill exercise stimulation therapy, once a day for a total of 60 minutes.

[0066] (3) Index detection method (3.1) Weight: measured using a bench scale.

[0067] (3.2) Muscle strength: A digital push-pull dynamometer (model: SH-111-50N) was used to measure the maximum muscle strength of the knee flexor muscle (biceps femoris) of the affected lower limb.

[0068] (3.3) Muscle thickness: PHILIPS color Doppler ultrasound (model: HD-11XE) was used to detect the muscle thickness of the knee flexor muscle (biceps femoris) of the affected lower limb.

[0069] (3.4) Nerve conduction velocity: The biofunctional experimental system (model: BL-420S) was used to detect the conduction velocity of the sciatic nerve disuse injury specimens of the affected lower limb of rats.

[0070] (4) Experimental results Comparison of the efficacy evaluation indexes of Madetuli Ayatemi ointment on the model of muscle weakness and muscle atrophy after peripheral nerve (sciatic nerve) disuse injury in rats ( ±s), the results are shown in Table 1.

[0071] The results in Table 1 show that a high dose of the Madituli Ayat agent of the present invention for treating disuse muscle weakness and muscular atrophy significantly improves the sciatic nerve conduction velocity, significantly increases the muscle strength and muscle content of the knee flexor muscle (biceps femoris), and significantly increases body weight (all P<0.05), and has a significant pharmacological effect in preventing and treating peripheral nerve disuse muscle weakness and muscular atrophy.

[0072] Comparison of the efficacy evaluation indicators of rehabilitation therapy combined with Madetuli Ayatemi ointment on the model of muscle weakness and muscle atrophy after peripheral nerve (sciatic nerve) disuse injury in rats ( ±s), and the results are shown in Table 2.

[0073] The results in Table 2 show that a high dose of the Madituliat agent for treating disuse muscle weakness and muscular atrophy of the present invention further enhances the rehabilitation therapeutic effect of the motor system, and plays a significant therapeutic role in preventing and treating peripheral nerve disuse muscle weakness and muscular atrophy.

[0074] 2. Clinical Trials (1) Research methods Methods Patients with disuse muscle weakness and muscular atrophy caused by muscular dystrophy were selected in the hospital (with no restrictions on age, gender, height, weight, and educational level) and divided into three groups according to the random number table method: conventional rehabilitation group (n=19), conventional rehabilitation + external application of Chinese medicine group (n=17), and conventional rehabilitation + external application of Chinese medicine + oral Chinese medicine group (n=19). Different treatment methods were used to intervene for 4 weeks, and a randomized controlled clinical experimental study was carried out.

[0075] (2) Intervention methods (2.1) Conventional rehabilitation group: The following three rehabilitation methods routinely used in the hospital were implemented: massage therapy, large joint mobilization training, and occupational therapy, for a total of 60 minutes.

[0076] (2.2) Routine rehabilitation + topical medication group: On the basis of routine rehabilitation in the hospital, topical medication treatment (which has the function of improving local blood circulation and increasing local muscle strength) and special hard therapy were implemented. Topical medication. Once a day, 10 ml each time.

[0077] (2.3) Routine rehabilitation + topical application + oral administration group: On the basis of routine rehabilitation + topical application in the hospital, oral administration was implemented. Twice a day, 8g each time, orally after meals.

[0078] (3) Index detection method (3.1) Blood test: Serum sampling and biochemical method are used to detect creatine kinase and myoglobin.

[0079] (3.2) Maximum muscle strength of the knee flexor (biceps femoris): A neuromuscular stimulator (model: EN-Stim4) was used and an electromyographic assessment report was collected.

[0080] (3.4) Muscle thickness of the knee flexor muscle (biceps femoris): Use color B-ultrasound and collect the ultrasound diagnosis report.

[0081] (3.5) Assessment of patients' activities of daily living (ADL): Use the Functional Independence Measurement (FIM) scale. Collect questionnaires.

[0082] (4) Experimental results Distribution of efficacy observation indicators of Madetuli Ayatemi ointment combined with basic stimulation rehabilitation therapy for patients with myasthenia caused by peripheral neuropathy (muscular dystrophy) ( ±s), the results are shown in Table 3. In Tables 1 to 3, a is compared with the sham operation group, a P <0.05; bCompared with the model control group, b P <0.05; cCompared with the positive control group, c P <0.05; d Compared with the low-dose Chinese medicine group, d P <0.05; eCompared with the medium-dose Chinese medicine group, e P <0.05; fCompared with the high-dose Chinese medicine group, f P <0.05; jCompared with the basic stimulation rehabilitation treatment group, j P <0.05; h Compared with the basic stimulation rehabilitation treatment + high-dose Chinese medicine group, h P <0.05; iCompared with the conventional rehabilitation group, i P <0.05; g conventional rehabilitation + external application medication group, g P <0.05; k compared with the group before and after treatment, k P <0.05.

[0083] The results in Table 3 show that before the intervention, patients with myasthenia and muscular atrophy caused by peripheral neuropathy (muscular dystrophy) had movement disorders, decreased self-care ability, and critical values ​​of creatine kinase and myoglobin. After 4 weeks of treatment with the Madetuli Ayatemi ointment for preventing and treating disuse myasthenia and muscular atrophy of the present invention, the measured values ​​of serum creatine kinase and myoglobin showed a downward trend, and the measured values ​​of the maximum muscle strength and thickness of the biceps femoris muscle of the affected lower limb, as well as the ADL assessment value of the patients' self-care ability in daily living activities showed an upward trend (all P<0.05).

[0084] Therefore, it can be seen that the madituliat agent of the present invention for preventing and treating disuse muscle weakness and muscular atrophy plays a significant therapeutic role in preventing and treating patients with disuse muscle weakness and muscular atrophy caused by peripheral neuropathy, and has a good clinical promotion and application value.

[0085] In summary, the present invention inherits the medication characteristics of traditional Chinese Uygur medicine, takes traditional Chinese medicine theory as a guide, and based on long-term clinical practice, ensures the content of effective components, and the components play a synergistic role, thereby improving the bioavailability. It has the function of treating various diseases of dampness, coldness or abnormal tasteless mucus, plays a significant role in preventing and treating disuse muscle weakness and muscle atrophy caused by various reasons, and has very important social significance and economic value.

[0086] The above technical features constitute the embodiments of the present invention, which have strong adaptability and implementation effect. Non-essential technical features can be added or reduced according to actual needs to meet the requirements of different situations.

Claims

1. A madituli ayat for treating disuse-related myasthenia and muscular atrophy, characterized in that The raw materials include main ingredients and auxiliary ingredients. The main ingredients are calculated by weight, including 45 to 50 parts of dried ginger, 35 to 40 parts of black pepper, 35 to 40 parts of white pepper, 35 to 40 parts of longan, 35 to 40 parts of cinnamon, 35 to 40 parts of chamomile, 35 to 40 parts of African stephania roots, 15 to 20 parts of colchicum, 35 to 40 parts of emblica fruit, 35 to 40 parts of plumbagin, 35 to 40 parts of central asian white ginseng, 35 to 40 parts of European polygonatum, 35 to 40 parts of Nymphoides oleifera seeds, and 30 parts of schizonepeta tenuifolia seeds. 5 to 40 parts, 15 to 20 parts of deer antlers, 35 to 40 parts of frankincense, 35 to 40 parts of nutmeg, 15 to 20 parts of asarone, 15 to 20 parts of galangal, 15 to 20 parts of carrot seeds, 15 to 20 parts of ophiopogon japonicus, 35 to 40 parts of terminalia chebula flesh, and 35 to 40 parts of milk peach. The auxiliary material is honey. The Madituliat agent for treating disuse myasthenia and muscular atrophy includes Madituliat honey paste and Madituliat pills according to the dosage form.

2. The method for treating disuse myasthenia and muscular atrophy according to claim 1, characterized in that Madetulyaiat honey paste is prepared according to the following steps: S1, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S2, heating the honey after removing impurities to obtain refined honey for later use; S3, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain the Made Tuli Ayat honey paste.

3. The method for treating disuse myasthenia and muscular atrophy according to claim 2, characterized in that In step S3, 100 g of mixed medicinal powder is added to every 300 g of refined honey.

4. The madituliayat for treating disuse myasthenia and muscular atrophy according to any one of claims 1 to 3, characterized in that Madetulyaat pills are prepared according to the following steps: S11, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S12, heating the honey from which impurities have been removed to obtain refined honey for later use; S13, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain Madetuliayat pills.

5. The method for treating disuse myasthenia and muscular atrophy according to claim 4, characterized in that In step S13, 100 g of mixed medicinal powder is added to every 50 g of refined honey.

6. A method for preparing the madulatide for treating disuse myasthenia and muscular atrophy according to claim 1, characterized in that Madetulyaiat honey paste is prepared according to the following steps: S1, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S2, heating the honey after removing impurities to obtain refined honey for later use; S3, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain the Made Tuli Ayat honey paste.

7. The method for preparing the madurat for treating disuse myasthenia and muscular atrophy according to claim 6, characterized in that In step S3, 100 g of mixed medicinal powder is added to every 300 g of refined honey.

8. The method for preparing the madurat for treating disuse myasthenia and muscular atrophy according to claim 6 or 7, characterized in that The preparation method of Madetuly Ayat Pills is prepared according to the following steps: S11, crushing the selected, cleaned and dried raw materials of dried ginger, black pepper, white pepper, long pepper, cinnamon, chamomile, African stephania root, colchicum, emblica fruit, plumbaginous plant, Bletilla striata, Polygonatum odoratum, Nymphoides ovata seed, antler, nutmeg, asarum, galangal, carrot seed, ophiopogon japonicus, terminalia chebula pulp and milk peach into powder, and grinding frankincense separately, sterilizing and sieving them respectively, and then weighing the required amount of the clean medicinal materials of the raw materials in turn to mix them to obtain a mixed powder; S12, heating the honey from which impurities have been removed to obtain refined honey for later use; S13, adding the mixed medicinal powder into the refined honey, mixing and lumping the materials together to obtain Madetuliayat pills.

9. The method for preparing the madurat for treating disuse myasthenia and muscular atrophy according to claim 6, 7 or 8, characterized in that In step S13, 100 g of mixed medicinal powder is added to every 50 g of refined honey.

10. Use of the madituliat agent for treating disuse muscle weakness and muscular atrophy according to any one of claims 1 to 5 in the preparation of a drug for preventing, treating and / or treating disuse muscle weakness and muscular atrophy.

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