Portable painless injection device with double piezoelectric micropump functions

Abstract

The invention discloses a portable painless injection device with double piezoelectric micropumps, and belongs to the technical field of medical instruments, the portable painless injection device comprises a medicine storage assembly, a piezoelectric liquid pump, an injection microneedle, an annular elastic binding belt and a piezoelectric air pump, and a pump body is provided with a heating device; the injection micro-needle is composed of a hollow micro-needle head in a square array and a micro-needle base integrally connected with the hollow micro-needle head; the left side and the right side of the pump body are connected with an annular elastic binding belt, a flexible pressurizing air bag is arranged in the pump body, the flexible pressurizing air bag is inflated through the piezoelectric air pump, then the contact pressure between the injection microneedle and the epidermis is changed, and the heating device adjusts the temperature to control expression and release of a biological agent.

Description

Technical Field

[0001] The invention relates to the technical field of medical painless injection equipment, and in particular to a portable painless injection device with dual piezoelectric micro pumps. Background Art

[0002] At present, injection is one of the indispensable and important means in the medical process. The injection of various drugs in the actual clinical treatment of patients is inseparable from injection technology. Usually subcutaneous injection is used. The skin can be divided into epidermis, dermis and subcutaneous tissue from the outside to the inside. The dermis and subcutaneous tissue contain a large amount of nerve tissue. The nerve tissue will be destroyed during the subcutaneous injection process, resulting in stimulation and causing pain to the patient, which can easily cause the patient to have a rejection psychology.

[0003] At present, high-precision and quantitative drug injection technology is particularly important in clinical treatment, especially for expensive drugs, which urgently requires a high-precision injection device.

[0004] A portable painless injection device with dual piezoelectric micropumps is designed. The device is small and easy to carry, and can be fixed to specific parts of the body, such as the wrist, leg or abdomen. It can perform controllable and high-precision drug injections into the patient's epidermis, and then the epidermal stratum corneum will absorb the injected drugs, thereby achieving the purpose of painless injection.

[0005] Drugs delivered to the stratum corneum of the epidermis are absorbed slowly and are particularly suitable for topical administration. They can effectively reduce the harm caused to the human body by some highly toxic drugs with serious side effects. Summary of the invention

[0006] The purpose of the present invention is to solve the above problems and to provide a portable painless injection device with dual piezoelectric micro pumps.

[0007] A portable painless injection device with dual piezoelectric micro pumps, comprising: a drug storage component 1, a piezoelectric liquid pump 2, an injection micro needle 3, and an annular elastic binding belt 4;

[0008] The drug storage assembly 1 is fixed on the outside of the pump body 21 of the piezoelectric liquid pump 2, and the injection microneedle 3 is fixed on the inside of the piezoelectric liquid pump 2, at the liquid outlet valve chamber 26, and communicates with the liquid valve chamber 26;

[0009] The two ends of the annular elastic binding band 4 are fixed to the two ends of the pump body 21;

[0010] The medicine storage assembly 1 comprises: a medicine storage housing 10 and a medicine storage annular elastic medicine bag 11; the medicine storage annular elastic medicine bag 11 is arranged in the medicine storage housing 10; the inlet of the piezoelectric liquid pump 2 is connected to the medicine storage annular elastic medicine bag 11 through a steel needle 22, and the outlet of the piezoelectric liquid pump 2 is connected to the liquid outlet valve chamber 26;

[0011] The painless injection device is further provided with a piezoelectric pump 5. A flexible pressurized airbag 40 is provided in the annular elastic binding band 4. The flexible pressurized airbag 40 is provided with an airbag inlet 40a and an airbag deflation port. The outlet of the piezoelectric pump 5 is communicated with the airbag inlet 40a.

[0012] The medicine storage assembly 1 is annular and installed in the cavity of the liquid pump cavity 25;

[0013] The pump body 21 is provided with a heating device;

[0014] The heating device adjusts the temperature to control the temperature-sensitive terminator or promoter in the biopharmaceutical to start or stop the release of the biopharmaceutical;

[0015] The portable painless injection device with dual piezoelectric micro pumps is used in the treatment of skin tumors.

[0016] The invention provides a portable painless injection device with dual piezoelectric micropumps, belonging to the technical field of medical painless injection equipment, comprising: a medicine storage component, a piezoelectric liquid pump, an injection microneedle, an annular elastic binding belt, and a piezoelectric electric pump, wherein: the medicine storage component comprises a medicine storage shell with a hollow annular structure and an annular elastic medicine bag for storing medicine embedded therein, the annular elastic medicine bag for storing medicine is connected to the piezoelectric liquid pump through a steel needle, the piezoelectric liquid pump comprises a piezoelectric vibrator, a pump body, an inlet valve plate, and an outlet valve plate, the piezoelectric vibrator is formed by bonding PZT piezoelectric ceramics to a metal substrate, the outlet valve chamber of the piezoelectric liquid pump is connected to the injection microneedle; the injection microneedle is composed of a hollow microneedle head in a square array and a microneedle base integrally connected thereto; the left and right sides of the pump body are connected to an annular elastic binding belt, a flexible pressurized airbag is arranged inside the annular elastic airbag, the flexible pressurized airbag is inflated by the piezoelectric electric pump, and the contact pressure between the injection microneedle and the epidermis is changed.

[0017] In summary, the portable painless injection device with dual piezoelectric micropumps provided by the present invention has the following beneficial effects and advantages:

[0018] 1. The painless injection device of the present invention is provided with an annular elastic binding belt, which can initially fix the injection device to a specific part of the body, such as the wrist, leg or abdomen, and a flexible pressurized airbag is provided inside the annular elastic binding belt.

[0019] 2. The painless injection device of the present invention is provided with an injection microneedle, which is connected to the outlet valve chamber of the piezoelectric fluid pump. It is composed of a square array of micro hollow microneedle heads and a microneedle base integrally connected thereto. The length of the microneedle head is between 150-200 microns, ensuring that when piercing the skin, it only penetrates the stratum corneum of the epidermis of the skin and does not penetrate the dermis rich in blood vessels and sensory nerve endings.

[0020] 3. The painless injection device of the present invention is provided with a piezoelectric liquid pump for high-precision pumping of the liquid medicine; it is also provided with a piezoelectric electric pump for inflating the flexible pressurized airbag, thereby changing the contact pressure between the injection microneedle and the epidermis.

[0021] 4. The painless injection device of the present invention is provided with a drug storage component, which includes a drug storage shell with a hollow annular structure and an annular elastic drug storage bag embedded therein. The annular elastic drug storage bag is connected to the piezoelectric liquid pump through a steel needle. The bag skin itself has a certain tension, which is helpful for pumping the drug solution. The piezoelectric liquid pump can be controlled by a program to achieve precise and painless injection of the drug solution.

[0022] 5. A heating device is provided on the pump body 21 to control the temperature-sensitive terminator or promoter in the drug and control the expression and release of the biological agent by adjusting the temperature.

[0023] In summary, a portable painless injection device with dual piezoelectric micropumps is small and easy to carry, and can be fixed to specific parts of the body, such as the wrist, leg or abdomen. It can perform controllable and high-precision drug injections into the patient's epidermis, and then the epidermal stratum corneum will absorb the injected drugs, thereby achieving the purpose of painless injection. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 This is a schematic diagram of the three-dimensional structure of a portable painless injection device with dual piezoelectric micropumps according to the present invention;

[0025] Figure 2 It is a schematic diagram of the explosion structure of a portable painless injection device with dual piezoelectric micro pumps according to the present invention;

[0026] Figure 3 It is a schematic diagram of the specific structure of a pump body of a piezoelectric liquid pump of a portable painless injection device with dual piezoelectric micropumps according to the present invention;

[0027] Figure 4 This is a schematic diagram of the specific structure of an injection microneedle of a portable painless injection device with dual piezoelectric micropumps according to the present invention;

[0028] Figure 5 This is a cross-sectional view of the internal structure of a portable painless injection device with dual piezoelectric micropumps according to the present invention;

[0029] Figure 6 A is a cross-sectional view of the internal structure of a medicine storage component and a piezoelectric liquid pump of a portable painless injection device with dual piezoelectric micropumps according to the present invention;

[0030] Figure 7 This is a cross-sectional view B of the internal structure of the drug storage component and the piezoelectric liquid pump of a portable painless injection device with dual piezoelectric micropumps of the present invention;

[0031] Figure 8 This is a schematic diagram of the working principle of a portable painless injection device with dual piezoelectric micro pumps according to the present invention;

[0032] Fig. 9 This is a real picture of the piezoelectric liquid pump of the portable painless injection device with dual piezoelectric micro pumps of the present invention.

[0033] In the attached picture:

[0034] 1. Medicine storage component; 10. Medicine storage housing; 10a. Positioning groove; 11. Medicine storage annular elastic medicine bag; 11a. Silicone pad;

[0035] 2. Piezoelectric liquid pump; 20. Piezoelectric vibrator; 20a. PZT piezoelectric ceramics; 20b. Metal substrate; 21. Pump body; 21a. Positioning boss; 21b. Liquid inlet channel; 21c. Liquid outlet channel; 22. Steel needle; 23. Inlet valve plate; 24. Outlet valve plate; 25. Liquid pump cavity; 26. Liquid outlet valve chamber;

[0036] 3. Injection microneedle; 30. Microneedle base; 31. Microneedle head;

[0037] 4. Annular elastic restraint belt; 40. Flexible pressurized airbag; 40a. Airbag inlet; Airbag deflation port;

[0038] 5. Piezoelectric pump; 51. Air pump outlet. DETAILED DESCRIPTION

[0039] The following will be combined with the attached Figure 1-9 The advantages, purposes and features of the present invention are described more clearly and completely in the following specific implementation modes. It should be noted that the embodiments described below are only a part of all the embodiments of the present invention, but not all the embodiments.

[0040] Embodiment 1:

[0041] The invention discloses a portable painless injection device with dual piezoelectric micro pumps, comprising: a medicine storage component 1, a piezoelectric liquid pump 2, an injection micro needle 3, an annular elastic binding band 4, and a piezoelectric electric pump 5.

[0042] The drug storage assembly 1 includes: a drug storage shell 10 and a drug storage annular elastic drug bag 11. The drug storage shell 10 is a hollow annular structure, and the drug storage annular elastic drug bag 11 is embedded in the drug storage shell 10; the drug storage annular elastic drug bag 11 is connected to the piezoelectric liquid pump 2 through a steel needle 22.

[0043] A silicone pad 11a with moderate thickness is provided at the connection between the annular elastic medicine bag 11 and the steel needle 22. The silicone pad 11a passes through the lower opening of the medicine storage shell 10, and the outer end surface is flush with the lower surface of the medicine storage shell 10.

[0044] The piezoelectric liquid pump 2 includes: a piezoelectric vibrator 20, a pump body 21, an inlet valve plate 23, and an outlet valve plate 24, wherein the piezoelectric vibrator 20 is formed by bonding and compounding a PZT piezoelectric ceramic 20a and a metal substrate 20b, both of which are circular sheet structures, and the metal substrate 20b is sealed and connected to the cylindrical cavity of the pump body 21 to form a liquid pump chamber 25; the liquid inlet channel 21b of the pump body 21 is U-shaped, the outer side of which is fixedly and sealedly connected to the steel needle 22, and the inner side is connected to the liquid pump chamber 25 through the inlet valve plate 23; the liquid outlet channel 21c of the pump body 21 is linear, the upper side of which is connected to the liquid pump chamber 25, and the lower side is connected to the liquid outlet valve chamber 26 through the outlet valve plate 24.

[0045] The liquid outlet valve chamber 26 of the pump body 21 is a square groove structure, and a square positioning and mounting square groove for the injection microneedle 3 is provided at the lower part thereof, and the injection microneedle 3 is sealed and connected to the pump body 21 through the square positioning and mounting square groove; a positioning boss 21a is provided at the upper part of the pump body 21, and a positioning groove 10a is provided on the inner side of the drug reservoir shell 10, and the pump body 21 and the drug reservoir shell 10 are limited and fixed by the positioning boss 21a and the positioning groove 10a; referring to the accompanying drawings, the lower shell of the pump body 21 can be circular or square.

[0046] The injection microneedle 3 is composed of a square array of hollow microneedle heads 31 and a square microneedle base 30 integrally connected thereto. The length of the microneedle heads 31 is between 150 and 200 microns.

[0047] The external structure of the annular elastic binding belt 4 adopts a structure similar to a Velcro strap, and its two ends are respectively connected to the protruding connecting shaft structures on the left and right sides of the pump body 21. It is characterized in that a flexible pressurized airbag 40 is provided inside it, and the flexible pressurized airbag 40 is provided with an airbag inlet 40a and an airbag deflation port.

[0048] The piezoelectric pump 5 can be a passive valve piezoelectric pump. The piezoelectric pump 5 is arranged at the lower side of the annular elastic binding band 4, and its air pump outlet 51 is sealed and connected to the airbag inlet 40a.

[0049] The present invention provides a portable painless injection device with dual piezoelectric micropumps, and its working process and working principle are as follows:

[0050] First, the injection device of the present invention is initially fixed to a specific part of the patient's body, such as the wrist, leg or abdomen, using a circular elastic band 4. At this time, the injection microneedle 3 is in contact with the skin of the specific part of the body under the elastic force of the circular elastic band 4 itself;

[0051] Before injection, the piezoelectric pump 5 is used to inflate the flexible pressurized airbag 40 inside the annular elastic binding band 4. As the flexible pressurized airbag 40 is continuously inflated, under the action of gradually increasing pressure, the microneedle head 31 of the injection microneedle 3 obtains sufficient external force to pierce the epidermis of the skin. Since the length of the microneedle head 31 is between 150 and 200 microns, it is ensured that when piercing the skin, only the stratum corneum of the epidermis of the skin is penetrated, and the dermis rich in blood vessels and sensory nerve endings is not penetrated. At this time, the injection device enters the injection waiting state;

[0052] During injection, the steel needle 22 penetrates the silicone pad 11a to connect the annular elastic medicine bag 11 storing medicine to the liquid inlet channel 21b of the piezoelectric liquid pump 2. Figure 8 , the positive voltage of the external electric field acts on the piezoelectric vibrator 20, the piezoelectric vibrator 20 bends upward, the volume of the liquid pump chamber 25 increases and the internal pressure decreases, so that the inlet valve plate 23 bends toward the inside of the liquid pump chamber 25, and the liquid flows into the liquid pump chamber 25 through the U-shaped liquid inlet channel 21b. At this time, the outlet valve plate 24 is closed to block the liquid from entering the liquid outlet channel 21c, that is, the liquid flow is cut off, and the liquid pumping is completed;

[0053] The negative voltage of the external electric field acts on the piezoelectric vibrator 20, and the piezoelectric vibrator 20 bends downward, the volume of the liquid pump chamber 25 decreases, and the internal pressure increases. The inlet valve plate 23 is closed to block the drug liquid from entering the liquid pump chamber 25, that is, the inlet flow is cut off; the outlet valve plate 24 is bent toward the inside of the liquid outlet valve chamber 26, and the drug liquid in the liquid pump chamber 25 is pumped into the liquid outlet valve chamber 26 through the liquid outlet flow channel 21c; under the action of pressure, the drug liquid is injected into the epidermal stratum corneum of a specific part of the patient through the injection microneedle 3;

[0054] The piezoelectric vibrator 20 is continuously stimulated by positive and negative voltages, and the drug solution is pumped into the liquid pump chamber 25 from the liquid inlet channel 21b of the piezoelectric liquid pump 2, and continuously pumped out from the liquid outlet channel 21c. The working process of the above-mentioned piezoelectric liquid pump 20 can be controlled by a program, thereby realizing precise and painless injection of the drug solution.

[0055] After the injection, the piezoelectric liquid pump 2 is first turned off to stop pumping and injecting the drug, and then the piezoelectric electric pump 5 is turned off. The gas in the flexible pressurized airbag 40 is discharged from the airbag vent of the flexible pressurized airbag 40 under the action of the airbag tension, and the contact pressure between the injection microneedle 3 and the skin is reduced, and the two return to the initial contact state; finally, the annular elastic restraint band 4 is untied to remove the injection device of the present invention;

[0056] Before the patient's next drug injection, it is necessary to replace the new drug storage component 1 in advance and repeat the above operation.

[0057] In summary, the present invention provides a portable painless injection device with dual piezoelectric micropumps. The device is small and easy to carry, and can be fixed to specific parts of the body, such as the wrist, leg or abdomen. It can perform controllable and high-precision drug injections into the patient's epidermis, and then the epidermal stratum corneum will absorb the injected drugs, thereby achieving the purpose of painless injection.

Claims

1. A portable painless injection device with dual piezoelectric micropumps, comprising: Drug storage component (1), piezoelectric fluid pump (2), injection microneedle (3), annular elastic binding band (4); The drug storage component (1) is fixed on the outside of the pump body (21) of the piezoelectric liquid pump (2), and the injection microneedle (3) is fixed on the inside of the piezoelectric liquid pump (2), at the liquid outlet valve chamber (26), and is in communication with the liquid outlet valve chamber (26); The two ends of the annular elastic binding band (4) are fixed to the two ends of the pump body (21); The medicine storage assembly (1) comprises: a medicine storage housing (10) and a medicine storage annular elastic medicine bag (11); the medicine storage annular elastic medicine bag (11) is arranged in the medicine storage housing (10); the inlet of the piezoelectric liquid pump (2) is connected to the medicine storage annular elastic medicine bag (11) through a steel needle (22), and the outlet of the piezoelectric liquid pump (2) is connected to the liquid outlet valve chamber (26); The microneedle head of the injection microneedle is 150-200 microns in length.

2. A portable painless injection device with dual piezoelectric micropumps according to claim 1, characterized in that: The injection microneedle (3) is composed of a square array of hollow microneedle heads (31) and a square microneedle base (30) integrally connected thereto.

3. A portable painless injection device with dual piezoelectric micropumps according to claim 2, characterized in that: A piezoelectric pump (5) is also provided. A flexible pressurized airbag (40) is provided in the annular elastic binding band (4). The flexible pressurized airbag (40) is provided with an airbag inlet (40a) and an airbag deflation port. The outlet of the piezoelectric pump (5) is in communication with the airbag inlet (40a).

4. A portable painless injection device with dual piezoelectric micropumps according to claim 3, characterized in that: The medicine storage component (1) is annular and is installed in the cavity of the liquid pump cavity (25).

5. A portable painless injection device with dual piezoelectric micropumps according to claim 4, characterized in that: The pump body (21) is provided with a heating device.

6. A portable painless injection device with dual piezoelectric micropumps according to claim 5, characterized in that: The heating device controls the temperature-sensitive terminator or promoter in the biological medicine by adjusting the temperature, and starts or stops the release of the biological medicine.

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