Preparation method and application of a product for dredging collaterals to relieve pain and generating heat by itself

Abstract

The present invention belongs to the field of traditional Chinese medicine pain-relieving patches, and specifically discloses a preparation method and application of a self-heating product for dredging collaterals and relieving pain; this method uses a variety of Chinese herbal medicines including Erigeron breviscapus as raw materials, and obtains an extract for dredging collaterals and relieving pain through extraction and concentration processes, and then dilutes it and soaks non-woven fabric to make a medicinal paper layer. At the same time, a heat-generating layer is made by wrapping heat-generating materials such as iron powder and activated carbon with a film-coated non-woven fabric, and is fixed to the medicinal paper layer and the anti-adhesive layer by hot pressing to obtain a self-heating product. In addition, non-steroidal anti-inflammatory drugs such as ibuprofen can also be added to the extract for dredging collaterals and relieving pain to enhance the pain-relieving effect. During the preparation process, various process parameters such as extraction temperature and concentration pressure need to be strictly controlled to ensure product quality. After the product is prepared, it needs to be packaged in a sealed bag to isolate air to maintain its self-heating effect and medicinal efficacy. The present invention has the effects of dredging collaterals and relieving pain, and warming and soothing, and is suitable for relieving pain and discomfort caused by rheumatism, arthritis, etc.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine pain-relieving patches, and specifically discloses a preparation method and application of a self-heating product for dredging collaterals and relieving pain. Background Art

[0002] In modern society, with the acceleration of the pace of life and the increase of work pressure, more and more people are facing problems such as physical fatigue, muscle tension and joint pain. In order to relieve these symptoms, various dredging collaterals and relieving pain products have emerged on the market, including plasters, hot compress packs, self-heating products, etc. However, although these products can provide certain relief to a certain extent, there are still many deficiencies in terms of effect and user experience.

[0003] Most of the current self-heating products for dredging collaterals and relieving pain on the market are prepared using traditional Chinese herbal medicine formulas. These products extract the active ingredients of Chinese herbal medicines and then coat them on the heating materials. The heating materials generate heat through oxidation reactions, so that the active ingredients of Chinese herbal medicines can penetrate into the skin to achieve the effect of dredging collaterals and relieving pain. However, these products often lack innovation and optimization in the formula, resulting in unsatisfactory product effects. Although some products can generate a certain amount of heat, the content of the active ingredients of Chinese herbal medicines is low and the permeability is poor, making the therapeutic effect of the products limited.

[0004] In addition, the existing self-heating products also have the problem of insufficient heating time. The heating time of many products is short and cannot meet the long-term needs of users. In order to extend the heating time, some products have to increase the dosage of the heating materials, but this will lead to an increase in the cost of the products and may generate too high a temperature, causing discomfort to the skin.

[0005] In the selection of Chinese medicinal materials, although some traditional Chinese herbal medicines such as wolfberry fruit, aralia chinensis and radix clematidis have the effect of dredging collaterals and relieving pain, their single use often has limited effects. As a Chinese medicinal material with significant medicinal value, erigeron breviscapus contains a variety of active ingredients and has the effects of promoting blood circulation to remove blood stasis and dredging collaterals and relieving pain. However, in the existing dredging collaterals and relieving pain products, the application of erigeron breviscapus is not extensive. This is mainly because the extraction and purification of the active ingredients of erigeron breviscapus are difficult, and its compatibility with traditional Chinese herbal medicines also needs further research and optimization.

[0006] In addition, as a class of commonly used antipyretic and analgesic drugs, non-steroidal anti-inflammatory drugs have significant anti-inflammatory and analgesic effects. However, in the existing dredging collaterals and relieving pain products, non-steroidal anti-inflammatory drugs are rarely combined with Chinese herbal medicines. This is mainly because the pharmacological effects of non-steroidal anti-inflammatory drugs may interact with the complex components of Chinese herbal medicines, and their safety and effectiveness also need to be further verified.

[0007] In the design of the heating layer, most of the existing self-heating products use a single layer of heating material, which results in deficiencies in the heating time and temperature control of the products. Although some products attempt to use multiple layers of heating materials to extend the heating time, the multi-layer structure often increases the thickness and weight of the products, reducing the user's comfort.

[0008] In summary, there are many deficiencies in the existing self-heating products for dredging collaterals and relieving pain in terms of formula, selection of traditional Chinese medicines, drug combination, and heating layer design, resulting in unsatisfactory therapeutic effects and user experiences of the products. Therefore, it is necessary to develop a new type of self-heating product for dredging collaterals and relieving pain to overcome the defects of the existing technology. Summary of the Invention

[0009] To solve the above problems, the present invention discloses a preparation method and application of a self-heating product for dredging collaterals and relieving pain.

[0010] The technical solution of the present invention is as follows:

[0011] A preparation method of a self-heating product for dredging collaterals and relieving pain, comprising the following steps:

[0012] Step 1: Prepare a dredging collaterals and relieving pain extract: Using wolfberry fruit, aralia elata, chicken root, small red ginseng, poria cocos, chrysanthemum, equisetum hiemale, and erigeron breviscapus as active raw materials, prepare a dredging collaterals and relieving pain extract through extraction and concentration processes;

[0013] Step 2: Make a medicinal paper layer: Dilute the dredging collaterals and relieving pain extract to a multiple conducive to absorption and uniform distribution, soak the non-woven fabric in the extract, allow the extract to penetrate into the interior of the non-woven fabric, and then enter the drying tunnel for drying;

[0014] Step 3: Assemble the product: Stack the medicinal paper layer, heating layer, and anti-sticking layer in sequence, and fix them by hot pressing to obtain a self-heating product;

[0015] The dredging collaterals and relieving pain extract is made from the following raw materials in parts by weight:

[0016]

[0017] The heating layer is composed of iron powder, activated carbon, salt, water, and water-absorbing resin wrapped in a non-woven fabric composite breathable film.

[0018] Further, in the above preparation method of a self-heating product for dredging collaterals and relieving pain, the preparation process of the non-woven fabric composite breathable film includes: using PE and Ca2CO3 as raw materials, mixing them evenly and then forming and stretching to form a breathable non-woven fabric.

[0019] Further, in the above preparation method of a self-heating product for dredging collaterals and relieving pain, the particle size range of Ca2CO3 is 3-4 μm.

[0020] Furthermore, the preparation method of the above-mentioned Tongluo Zhitong Healing Product is that the Tongluo Zhitong Extract is prepared by the following process flow:

[0021] S1 Extraction

[0022] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0023] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0024] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0025] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0026] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0027] S2 Merge Concentration

[0028] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0029] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0030] S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C;

[0031] S3 mixed cream

[0032] S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well;

[0033] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0034] S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0035] Furthermore, the preparation method of the above-mentioned product for promoting blood circulation and relieving pain and generating heat spontaneously, the preparation method of the extract of Erigeron breviscapus comprises the following steps:

[0036] 1) Pretreatment: Select fresh, pest-free, and mildew-free Erigeron breviscapus medicinal materials as raw materials, wash the medicinal materials, remove dirt, impurities, and dust on the surface, and then crush them through a 50-100 mesh sieve to obtain Erigeron breviscapus powder;

[0037] 2) Supercritical extraction: Add the Erigeron breviscapus powder into a supercritical carbon dioxide extraction device for extraction; the entrainer is an ethanol aqueous solution with a volume percentage concentration of 95%;

[0038] Among them, the extraction temperature is 48°C to 52°C, the temperature of the first separator is 35°C, and the temperature of the second separator is 25°C; the pressure of the extractor is 13 MPa to 17 MPa, the pressure of the first separator is 8 MPa, and the pressure of the second separator is 5 MPa; start timing when the temperatures and pressures of the extractor, the first separator, and the second separator reach the set values, and the extraction time is 100 minutes to 120 min; obtain the extract;

[0039] 3) Enzymatic hydrolysis: Put the extract into the enzymatic hydrolysis solution at a volume ratio of 1:9 for enzymatic hydrolysis, the enzymatic hydrolysis temperature is 30 - 40°C, and ultrasonic waves are used to promote enzymatic hydrolysis during enzymatic hydrolysis; the enzymatic hydrolysis solution contains 200 - 300 U / mL of cellulase, 100 - 200 U / mL of pectinase, and 50 - 100 U / mL of neutral protease, and the balance is water; filter after enzymatic hydrolysis for 12 - 36 h, and collect the enzymatic hydrolysis solution;

[0040] 4) Low-temperature concentration: Concentrate the enzymatic hydrolysis solution at low temperature until the relative density ≥ 1.30 g / mL to obtain the Erigeron breviscapus extract.

[0041] Furthermore, for the above preparation method of a self-heating product for dredging collaterals and relieving pain, after the self-heating product is prepared, it is put into a sealed bag for airtight packaging.

[0042] Furthermore, for the above preparation method of a self-heating product for dredging collaterals and relieving pain, the dredging collaterals and relieving pain extract also contains non-steroidal anti-inflammatory drugs.

[0043] Furthermore, for the above preparation method of a self-heating product for dredging collaterals and relieving pain, the dredging collaterals and relieving pain extract is made from the following raw materials in parts by weight:

[0044]

[0045] Furthermore, for the above preparation method of a self-heating product for dredging collaterals and relieving pain, the dredging collaterals and relieving pain extract is prepared by the following technological process:

[0046] S1 Extraction

[0047] S11 Put the Chinese wolfberry, Aralia chinensis, Radix seu Caulis Ixeris dentatae, Radix seu Caulis Rubiae yunnanensis, Poria cocos, Chrysanthemum morifolium, and Equisetum hiemale pieces into the extraction tank;

[0048] S12 First water extraction: Add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0049] S13 Second water extraction: Add 8 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0050] S14 Third water extraction: Add drinking water with a mass 6 times that of the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0051] S15 After each water extraction, filter the medicinal liquid and discard the medicinal residues;

[0052] S2 Combine and concentrate

[0053] S21 Combine the medicinal liquids extracted three times and perform vacuum concentration;

[0054] S22 Control the pressure of the concentration equipment at -0.01 - 0.07 MPa and the temperature at 55 - 85°C;

[0055] S23 Concentrate to a relative density of 1.15 - 1.25 g / mL at 80 ± 5°C;

[0056] S3 Mix and collect the extract

[0057] S31 Add Erigeron breviscapus extract and ibuprofen to the concentrated liquid and mix evenly;

[0058] S32 Perform vacuum concentration again, control the pressure of the equipment at -0.01 - 0.07 MPa and the temperature at 50 - 88°C;

[0059] S33 Concentrate to a relative density ≥ 1.30 g / mL at 83 ± 5°C to obtain the Tongluo Zhitong extract.

[0060] The present invention also discloses a self - heating product for promoting blood circulation to remove meridian obstruction and relieve pain, which is obtained by the method described in any one of the above.

[0061] The present invention also discloses the application of a self - heating product for promoting blood circulation to remove meridian obstruction and relieve pain in the preparation of a hot compress patch for promoting blood circulation to remove meridian obstruction and relieve pain, and the self - heating product for promoting blood circulation to remove meridian obstruction and relieve pain is obtained by the method described above.

[0062] Compared with the prior art, the innovation points of the present invention are as follows:

[0063] Addition of Erigeron breviscapus: The present invention first adds Erigeron breviscapus as one of the active ingredients to the self - heating product. By extracting the effective components of Erigeron breviscapus and formulating them with other Chinese herbal medicines, the Tongluo Zhitong extract is prepared; at the same time, we combine the Tongluo Zhitong extract with a heating layer that can generate steam and heat evenly to form a self - heating product. Through the steam, the active drugs in the medicinal paper layer can better exude, producing better curative effects; at the same time, the addition of Erigeron breviscapus significantly improves the effect of promoting blood circulation to remove meridian obstruction and relieve pain of the product, enabling the product to better relieve the pain and discomfort of users.

[0064] Furthermore, in some embodiments, the present invention also for the first time combines Erigeron breviscapus with non-steroidal anti-inflammatory drugs. Through reasonable ratio and preparation process, the two can act synergistically to further enhance the anti-inflammatory and analgesic effects of the product. This combination method not only improves the therapeutic effect of the product, but also reduces the side effects that may be brought by a single drug.

[0065] In summary, the self-heating product for dredging collaterals and relieving pain of the present invention has innovations in formula, selection of Chinese medicinal materials, preparation and selection of the heating layer, and drug combination, significantly improving the therapeutic effect of the product and the user experience. BRIEF DESCRIPTION OF THE DRAWINGS

[0066] Figure 1 Comparison chart of the number of cured cases in Examples 1-6, Comparative Examples 1-3 and Control Example;

[0067] Figure 2 Comparison chart of the number of markedly effective cases in Examples 1-6, Comparative Examples 1-3 and Control Example;

[0068] Figure 3 Comparison chart of the number of effective cases in Examples 1-6, Comparative Examples 1-3 and Control Example;

[0069] Figure 4 Comparison chart of the effective rate (%) in Examples 1-6, Comparative Examples 1-3 and Control Example. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0070] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0071] Example 1

[0072] A preparation method of a self-heating product for dredging collaterals and relieving pain includes the following steps:

[0073] Step 1: Prepare the dredging collaterals and relieving pain extract: Using wolfberry fruit, aralia elata, chicken root, small red ginseng, poria cocos, chrysanthemum, equisetum and erigeron breviscapus as active raw materials, prepare the dredging collaterals and relieving pain extract through extraction and concentration processes;

[0074] Step 2: Make the medicine paper layer: Dilute the dredging collaterals and relieving pain extract with ultrapure water by 5 times, soak the non-woven fabric in the extract to make the extract penetrate into the non-woven fabric, and then enter the drying tunnel for drying;

[0075] Step 3: Assemble the product: Stack the medicine paper layer, the heating layer and the anti-sticking layer in sequence, and fix them by hot pressing to obtain the self-heating product.

[0076] The Tongluo Zhitong Extract is prepared from the following raw materials in parts by weight:

[0077]

[0078] The Tongluo Zhitong Extract is prepared by the following technological process:

[0079] S1 Extraction

[0080] S11 Put the Chinese wolfberry, Aralia chinensis, Radix Polygalae, Radix Salviae Przewalskii, Poria cocos, Chrysanthemum morifolium, and Equisetum ramosissimum decoction pieces into the extraction tank;

[0081] S12 First water extraction: Add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0082] S13 Second water extraction: Add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0083] S14 Third water extraction: Add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0084] S15 After each water extraction, filter the medicinal liquid and discard the residue;

[0085] S2 Combine and concentrate

[0086] S21 Combine the medicinal liquids extracted three times and conduct vacuum concentration;

[0087] S22 Control the pressure of the concentration equipment at -0.01 - 0.07 MPa and the temperature at 55 - 85°C;

[0088] S23 Concentrate to a density of 1.15 - 1.25 g / mL at 80 ± 5°C;

[0089] S3 Mix and collect the extract

[0090] S31 Add the Erigeron breviscapus extract to the concentrated liquid and mix evenly; (The Erigeron breviscapus extract is purchased from Shaanxi Snow Biological Technology Co., Ltd., with a specific gravity of 1.0 - 1.2)

[0091] S32 Conduct vacuum concentration again, control the pressure of the equipment at -0.01 - 0.07 MPa and the temperature at 50 - 88°C;

[0092] S33 Concentrate to a density ≥ 1.30 g / mL at 83 ± 5°C to obtain the Tongluo Zhitong Extract.

[0093] The heating layer is composed of the content of iron powder, activated carbon, salt, water, and water-absorbing resin wrapped by non-woven fabric composite breathable film.

[0094] The preparation process of the non-woven composite breathable film includes: using PE and Ca2CO3 as raw materials, mixing them evenly and then forming and stretching the film to form a breathable non-woven fabric, and the particle size range of the Ca2CO3 is 3-4μm.

[0095] After the product is prepared, it is put into a sealed bag for air-insulated packaging.

[0096] Example 2

[0097] A preparation method of a dredging collaterals and relieving pain self-heating product includes the following steps:

[0098] Step 1: Prepare the dredging collaterals and relieving pain extract: Using wolfberry fruit, aralia elata, radix clematidis, ginseng, poria cocos, chrysanthemum, equisetum hiemale and erigeron breviscapus as active raw materials, and obtaining the dredging collaterals and relieving pain extract through extraction and concentration processes;

[0099] Step 2: Make the medicinal paper layer: Dilute the dredging collaterals and relieving pain extract 5 times with ultrapure water, soak the non-woven fabric in the extract to make the extract penetrate into the non-woven fabric, and then enter the drying tunnel for drying;

[0100] Step 3: Assemble the product: Stack the medicinal paper layer, the heating layer and the anti-sticking layer in sequence and fix them by hot pressing to obtain the self-heating product.

[0101] The dredging collaterals and relieving pain extract is made from the following raw materials by weight:

[0102]

[0103] The dredging collaterals and relieving pain extract is prepared by the following technological process:

[0104] S1 Extraction

[0105] S11 Put the wolfberry fruit, aralia elata, radix clematidis, ginseng, poria cocos, chrysanthemum and equisetum hiemale slices into the extraction tank;

[0106] S12 First water extraction: Add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95°C;

[0107] S13 Second water extraction: Add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0108] S14 Third water extraction: Add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0109] S15 After each water extraction, filter the medicinal liquid and discard the residue;

[0110] S2 Combine and concentrate

[0111] S21 Combine the medicinal liquids extracted three times and carry out vacuum concentration;

[0112] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0113] S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C;

[0114] S3 mixed cream

[0115] S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well; (Erigeron breviscapus extract was purchased from Shaanxi Snort Biotechnology Co., Ltd. with a specific gravity of 1.0-1.2)

[0116] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0117] S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0118] The heating layer is composed of a non-woven composite breathable film wrapping the contents of iron powder, activated carbon, salt, water, and water-absorbent resin.

[0119] The preparation process of the non-woven composite breathable film includes: using PE and Ca2CO3 as raw materials, mixing them, forming a film and stretching them to form a breathable non-woven fabric, and the particle size of the Ca2CO3 is in the range of 3-4 μm.

[0120] After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

[0121] Example 3

[0122] A method for preparing a spontaneously heating product for dredging meridians and relieving pain, comprising the following steps:

[0123] Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process;

[0124] Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract with ultrapure water by 5 times, soak the non-woven fabric in the extract, make the extract penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying;

[0125] Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, fix them by hot pressing to obtain a self-heating product.

[0126] The analgesic extract is made from the following raw materials in parts by weight:

[0127]

[0128] The Tongluo Zhitong Extract is prepared by the following technological process:

[0129] S1 Extraction

[0130] S11 Put the Chinese wolfberry fruits, Aralia chinensis, Radix Polygalae, Potentilla discolor, Poria cocos, Chrysanthemum morifolium, and Equisetum ramosissimum decoction pieces into the extraction tank;

[0131] S12 First water extraction: Add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0132] S13 Second water extraction: Add 8 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0133] S14 Third water extraction: Add 6 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0134] S15 After each water extraction, filter the medicinal liquid and discard the medicinal residues;

[0135] S2 Merge and concentrate

[0136] S21 Merge the medicinal liquids extracted three times and conduct vacuum concentration;

[0137] S22 Control the pressure of the concentration equipment at -0.01 - 0.07 MPa and the temperature at 55 - 85°C;

[0138] S23 Concentrate to a density of 1.15 - 1.25 g / mL at 80 ± 5°C;

[0139] S3 Mix and collect the extract

[0140] S31 Add the Erigeron breviscapus extract to the concentrated liquid and mix evenly; (The Erigeron breviscapus extract is purchased from Shaanxi Snow Biotechnology Co., Ltd., with a specific gravity of 1.0 - 1.2)

[0141] S32 Conduct vacuum concentration again, control the pressure of the equipment at -0.01 - 0.07 MPa, and the temperature at 50 - 88°C;

[0142] S33 Concentrate to a density ≥ 1.30 g / mL at 83 ± 5°C to obtain the Tongluo Zhitong Extract.

[0143] The heating layer is composed of iron powder, activated carbon, salt, water, and water-absorbing resin wrapped by a non-woven fabric composite breathable film.

[0144] The preparation process of the non-woven fabric composite breathable film includes: Using PE and Ca2CO3 as raw materials, mixing them evenly and then forming and stretching to form a breathable non-woven fabric, and the particle size range of Ca2CO3 is 3 - 4 μm.

[0145] After the product is prepared, it is put into a sealed bag for airtight packaging.

[0146] Example 4

[0147] Same as Example 2, but the Erigeron breviscapus extract is prepared by oneself, including the following steps:

[0148] 1) Pretreatment: Select fresh Erigeron breviscapus medicinal materials without diseases, pests and mildew as raw materials, wash the medicinal materials to remove the soil, impurities and dust on the surface, and then crush and sieve through a 50-100 mesh sieve to obtain Erigeron breviscapus powder;

[0149] 2) Supercritical extraction: Add the Erigeron breviscapus powder to a carbon dioxide supercritical extraction device for extraction; the entrainer is an ethanol aqueous solution with a volume percentage concentration of 95%;

[0150] Among them, the extraction temperature is 48°C to 52°C, the temperature of the first separator is 35°C, and the temperature of the second separator is 25°C; the pressure of the extractor is 13MPa to 17MPa, the pressure of the first separator is 8MPa, and the pressure of the second separator is 5MPa; when the temperatures and pressures of the extractor, the first separator and the second separator reach the set values, start timing, and the extraction time is 100 minutes to 120 min; obtain the extract;

[0151] 3) Enzymatic hydrolysis: Put the extract into the enzymatic hydrolysis solution according to a volume ratio of 1:9 for enzymatic hydrolysis, the enzymatic hydrolysis temperature is 30-40°C, and ultrasonic waves are used to promote enzymatic hydrolysis during enzymatic hydrolysis; the enzymatic hydrolysis solution contains 200-300 U / mL of cellulase, 100-200 U / mL of pectinase and 50-100 U / mL of neutral protease, and the balance is water; after enzymatic hydrolysis for 12-36 h, filter and collect the enzymatic hydrolysis solution;

[0152] 4) Low-temperature concentration: Concentrate the enzymatic hydrolysis solution at low temperature to a relative density ≥1.30 g / mL to obtain the Erigeron breviscapus extract.

[0153] Example 5

[0154] Same as Example 2, but also contains 7.5 parts of ibuprofen.

[0155] Example 6

[0156] Same as Example 4, but also contains 7.5 parts of ibuprofen.

[0157] Comparative Example 1

[0158] A preparation method of a self-heating product for dredging collaterals and relieving pain includes the following steps:

[0159] Step 1: Prepare a dredging collaterals and relieving pain extract: Use wolfberry fruit, Aralia chinensis, Radix seu Caulis Ixeris dentatae, Radix seu Caulis Panacis pseudo-ginseng, Poria cocos, chrysanthemum, Equisetum hiemale and Erigeron breviscapus as active raw materials, and obtain the dredging collaterals and relieving pain extract through extraction and concentration processes;

[0160] Step 2: Manufacture the medicinal paper layer: Dilute the Tongluo Zhitong extract with ultrapure water by 5 times, soak the non-woven fabric in the extract to allow the extract to penetrate into the interior of the non-woven fabric, and then enter the drying tunnel for drying;

[0161] Step 3: Assemble the product: Stack the medicinal paper layer, the heating layer, and the anti-sticking layer in sequence, and fix them by hot pressing to obtain the self-heating product.

[0162] The Tongluo Zhitong extract is made from the following raw materials in parts by weight:

[0163]

[0164] The Tongluo Zhitong extract is prepared by the following technological process:

[0165] S1 Extraction

[0166] S11 Put the Chinese wolfberry, aralia, chicken root, small red ginseng, poria cocos, chrysanthemum, and equisetum decoction pieces into the extraction tank;

[0167] S12 First water extraction: Add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0168] S13 Second water extraction: Add 8 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0169] S14 Third water extraction: Add 6 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C;

[0170] S15 After each water extraction, filter the medicinal liquid and discard the medicinal residues;

[0171] S2 Combine and concentrate

[0172] S21 Combine the medicinal liquids extracted three times and carry out vacuum concentration;

[0173] S22 Control the pressure of the concentration equipment at -0.01 - 0.07 MPa and the temperature at 55 - 85°C;

[0174] S23 Concentrate to a density of 1.15 - 1.25 g / mL at 80 ± 5°C to obtain the Tongluo Zhitong extract.

[0175] The heating layer is composed of the content iron powder, activated carbon, salt, water, vermiculite, and water-absorbing resin wrapped in a film-coated non-woven fabric.

[0176] After the product is prepared, put it into a sealed bag for airtight packaging.

[0177] This comparative example does not contain the Erigeron breviscapus extract compared with Example 2, and the rest are the same.

[0178] Comparative Example 2

[0179] Commercially available Aolangwei pain relief patch (far infrared).

[0180] Comparative Example 3

[0181] Compared with Example 2, this comparative example does not contain Erigeron breviscapus extract and contains 7.5 parts of ibuprofen; the rest are the same.

[0182] Comparative Example 4

[0183] Compared with Example 2, the heating layer of this comparative example is a common heating layer of warm baby, contains vermiculite, does not contain water and water-absorbing resin; the rest are the same.

[0184] Test Example

[0185] The promoting blood circulation to relieve pain self-heating products of Examples 1-6 and Comparative Examples 1-4 were all made into specimens for testing.

[0186] In order to evaluate the specific effects of the promoting blood circulation to relieve pain self-heating product of the present invention, tests were carried out respectively from aspects such as mouse writhing test, hot plate test and clinical cases. The experimental methods are as follows:

[0187] 1) Mouse writhing test: 220 mice were taken, with half males and half females, weighing 20 g to 30 g. They were randomly divided into 11 groups according to gender and weight, with 20 mice in each group. The groups were a blank control group (without drugs) and a drug administration group (10 groups). 24 hours before the experiment, the abdominal hair of the mice was shaved about 5 cm * 2 cm. The promoting blood circulation to relieve pain self-heating products of Examples 1-6, Comparative Examples 1-4 and the control group were taken and tied and fixed on the abdominal part of the mice. The pain relief patch was changed 2 times a day, each time for 12 hours, for 5 consecutive days. 60 minutes after the last replacement of the pain relief patch, 0.2 ml of acetic acid solution with a concentration of 0.6% was injected into the abdominal cavity of each mouse, and the number of writhing responses of the mice within the next 30 minutes was recorded. Statistical processing was carried out using one-way analysis of variance of SPSS 13.0 software (Windows version). The results are shown in Table 1.

[0188] 2) Hot plate experiment: A number of mice were placed on a hot plate pain threshold meter at a temperature of 55 - 60 °C. The time from when the mouse's hind foot touched the hot plate to when it licked its hind foot was used as the pain threshold index. Before the experiment, the pain threshold was measured on the hot plate pain threshold meter, and 200 mice with pain threshold values within 10 - 30 s were selected and randomly divided into a blank control group and a drug administration group (10 groups). The normal pain threshold value was measured twice repeatedly as the baseline pain threshold value of the group before drug administration. 24 h before the experiment, the abdominal hair of the mice was shaved off about 5 cm * 2 cm, and the self-heating products for dredging collaterals and relieving pain of Examples 1 - 6, Comparative Examples 1 - 4, and the control group were taken and tied and fixed on the abdominal part of the mice. The pain relief patches were changed 2 times a day, 12 hours each time, for 5 consecutive days. The pain threshold values of the mice were measured 60 min after the last drug administration, and the pain threshold values of the mice before and after drug administration were compared and statistically analyzed. The experimental results were statistically processed using SPSS 13.0 for windows One-Way ANOVA. The statistical processing used one-way analysis of variance with SPSS 13.0 software (Windows version). The results are shown in Table 1.

[0189] Table 1 Summary of test data on pain relief effect.

[0190]

[0191]

[0192] In the data of Table 1, by comparing Example 2 with Comparative Example 1, it can be seen that the addition of Erigeron breviscapus significantly improved the effect of dredging collaterals and relieving pain of the product, enabling the product to better relieve the pain and discomfort of mice; from the comparison between Example 2 and Example 4, it can be seen that the Erigeron breviscapus extract prepared by the method disclosed in the present invention has a better pain relief effect when used as an active substance compared with the commercially available ordinary Erigeron breviscapus extract; from the comparison between Example 2 and Example 4 with Comparative Examples 1 - 3, it can be seen that when Erigeron breviscapus and the non-steroidal anti-inflammatory drug ibuprofen are used in combination, through reasonable proportioning and preparation process, the two can act synergistically to further enhance the anti-inflammatory and analgesic effects of the product. From the comparison between Example 2 and Comparative Example 4, it can be seen that by using the heating layer in Example 2, compared with the traditional heating layer, the active drugs in the medicine paper layer can better exude through steam, producing a better curative effect.

[0193] 3) Volunteer trial

[0194] 1. Grouping:

[0195] The self-heating products prepared in Examples 1 - 6 and Comparative Examples 1 - 4 were used for a volunteer experiment on grouped patients with wind-cold arthritis diagnosed by traditional Chinese medicine. There were 220 cases, including 148 males and 72 females, aged between 50 and 75 years old, and they were randomly divided into 11 groups, including a blank control group (without drugs).

[0196] 2. Efficacy Evaluation Criteria

[0197] Cured: All symptoms and signs disappear, and functional activities return to normal;

[0198] Markedly effective: All symptoms disappear or the main symptoms disappear, and functional activities are basically normal;

[0199] Effective: The main symptoms basically disappear, and the main joint functions basically recover or show obvious improvement;

[0200] Ineffective: There is basically no progress compared with before treatment.

[0201] 3. Treatment Method

[0202] Select acupoints according to the pain site, stick the self-heating product on the underwear at the corresponding part, apply it once a day, 15 times in a row as one course of treatment, and a total of 2 courses of treatment are given.

[0203] 4. Treatment Effect

[0204] After 2 courses of treatment, the statistical results of the clinical observation of the treatment effect are shown in Table 2 and Figures 1-4 as follows.

[0205] Table 2 Statistical Results of Clinical Treatment Effect

[0206]

[0207]

[0208] Among them, the effective rate = (number of cured cases + number of markedly effective cases + number of effective cases) / number of cases in a single group.

[0209] In the clinical data of Table 2, through the comparison between Example 2 and Comparative Example 1, it can be seen that, similar to the animal experiment, the addition of Erigeron breviscapus significantly improves the effect of dredging collaterals and relieving pain of the product, enabling the product to better relieve the pain and discomfort of patients;

[0210] Similar to the animal experiment, from the comparison between Example 2 and Example 4, it can be seen that the Erigeron breviscapus extract prepared by the method disclosed in the present invention has a better analgesic effect when used as an active substance addition compared with the commercially available ordinary Erigeron breviscapus extract;

[0211] Similar to the animal experiment, from the comparison between Example 2 and Comparative Example 4, it can be seen that compared with the traditional heating layer, the active drug in the medicinal paper layer can better exude through steam, resulting in a better therapeutic effect.

[0212] Further, from the comparison between Example 2 and Example 4 and Comparative Examples 1-3, it can be seen that when erigeron breviscapus is combined with the non-steroidal anti-inflammatory drug ibuprofen, through reasonable proportioning and preparation processes, the two can act synergistically to further enhance the anti-inflammatory and analgesic effects of the product. This combination method not only improves the therapeutic effect of the product, but also reduces the side effects that may be brought by a single drug.

[0213] The above are only several limited preferred embodiments of the present invention, and the description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A preparation method of a self-heating product for dredging collaterals and relieving pain, characterized in that, It includes the following steps: Step 1: Prepare the Tongluo Zhitong Extract: Using wolfberry fruit, aralia elata, radix seu caulis embeliae ribes, ginseng rubra, poria cocos, chrysanthemum, equisetum hiemale and erigeron breviscapus as active raw materials, prepare the Tongluo Zhitong Extract through extraction and concentration processes; Step 2: Make the medicinal paper layer: Dilute the Tongluo Zhitong Extract to a multiple that is conducive to absorption and uniform distribution, soak the non-woven fabric in the extract, allow the extract to penetrate into the interior of the non-woven fabric, and then enter the drying tunnel for drying; Step 3: Assemble the product: Stack the medicinal paper layer, the heating layer and the anti-sticking layer in sequence, and fix them by hot pressing to obtain the self-heating product; The Tongluo Zhitong Extract is made from the following raw materials by weight: The heating layer is composed of iron powder, activated carbon, salt, water, and water-absorbing resin wrapped by a non-woven fabric composite breathable film.

2. The preparation method of a Tongluo Zhitong self-heating product according to claim 1, characterized in that The preparation process of the non-woven fabric composite breathable film includes: Using PE and Ca2CO3 as raw materials, mixing them evenly and then forming and stretching to form a breathable non-woven fabric.

3. The preparation method of a self-heating product for dredging channels and relieving pain according to claim 2, characterized in that, The particle size range of the Ca2CO3 is 3 - 4μm.

4. The preparation method of a self-heating product for dredging collaterals and relieving pain according to claim 1, characterized in that, The Tongluo Zhitong Extract is prepared by the following technological process: S1 Extraction S11 Put the cut pieces of wolfberry fruit, aralia elata, radix seu caulis embeliae ribes, ginseng rubra, poria cocos, chrysanthemum, and equisetum hiemale into the extraction tank; S12 First water extraction: Add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85 - 95°C; S13 Second water extraction: Add 8 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C; S14 Third water extraction: Add 6 times the mass of drinking water to the medicinal residues, boil for 1.5 hours, and control the temperature at 85 - 95°C; S15 After each water extraction, filter the medicinal liquid and discard the medicinal residues; S2 Combine and concentrate S21 Combine the medicinal liquids extracted three times and conduct vacuum concentration; S22 Control the pressure of the concentration equipment at -0.01 - 0.07MPa and the temperature at 55 - 85°C; S23 Concentrate to a density of 1.15 - 1.25g / mL, at 80 ± 5°C; S3 Mix and collect the extract S31 Add the erigeron breviscapus extract to the concentrated liquid and mix evenly; S32 Conduct vacuum concentration again, control the pressure of the equipment at -0.01 - 0.07MPa and the temperature at 50 - 88°C; S33 Concentrate to a density ≥ 1.30g / mL, at 83 ± 5°C to obtain the Tongluo Zhitong Extract.

5. The preparation method according to claim 1, characterized in that, The preparation method of the erigeron breviscapus extract includes the following steps: 1) Pretreatment: Select fresh, pest-free, and mildew-free erigeron breviscapus medicinal materials as raw materials, wash the medicinal materials to remove the soil, impurities, and dust on the surface, and then crush and sieve through a 50 - 100 mesh sieve to obtain erigeron breviscapus powder; 2) Supercritical extraction: Add the erigeron breviscapus powder to a carbon dioxide supercritical extraction device for extraction; The entrainer is an ethanol aqueous solution with a volume percentage concentration of 95%; The extraction temperature is 48°C to 52°C, the temperature of the first separator is 35°C, and the temperature of the second separator is 25°C; the pressure of the extractor is 13MPa to 17MPa, the pressure of the first separator is 8MPa, and the pressure of the second separator is 5MPa; the timing starts when the temperature and pressure of the extractor, the first separator, and the second separator reach the set value, and the extraction time is 100 minutes to 120 minutes; and an extract is obtained; 3) Enzymolysis: the extract is added into the enzymolysis solution at a volume ratio of 1:9 for enzymolysis at a temperature of 30-40°C, and ultrasonic wave is used to promote enzymolysis; the enzymolysis solution contains 200-300 U / mL of cellulase, 100-200 U / mL of pectinase and 50-100 U / mL of neutral protease, and the balance is water; after enzymolysis for 12-36 hours, the enzymolysis solution is filtered and collected; 4) Low temperature concentration: Low temperature concentration of the enzymatic hydrolysate to a phase density ≥ 1.30 g / mL to obtain the Erigeron breviscapus extract.

6. The preparation method of a self-heating product for dredging collaterals and relieving pain according to claim 1, characterized in that, After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

7. The preparation method of a self-heating product for dredging collaterals and relieving pain according to claim 1, characterized in that, The collateral-clearing and pain-relieving extract also contains nonsteroidal anti-inflammatory drugs.

8. The preparation method of a self-heating product for dredging collaterals and relieving pain according to claim 7, characterized in that, The analgesic extract is made from the following raw materials in parts by weight:

9. The preparation method of a self-heating product for dredging collaterals and relieving pain according to claim 7, characterized in that, The Tongluo Zhitong extract is prepared by the following process: S1 Extraction S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank; S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃; S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C; S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃; S15 After each water extraction, filter the liquid medicine and discard the medicine residue; S2 Merge Concentration S21 combines the three extracted medicinal solutions and performs reduced pressure concentration; The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃; S23 is concentrated to a relative density of 1.15-1.25 g / mL, 80±5°C; S3 mixed cream S31 Adding Erigeron breviscapus extract and ibuprofen to the concentrate and mixing well; S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃; S33 was concentrated to a relative density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

10. Use of a product with self-heating function for dredging collaterals and relieving pain in the preparation of a hot compress patch for dredging collaterals and relieving pain, characterized in that, The self-heating product for dredging meridians and relieving pain is prepared by the method described in any one of claims 1 to 9.

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