Gynecological tumor 3D printing implantation guide plate puncture path design method

Abstract

The invention discloses a gynecological tumor 3D printing implantation guide plate puncture path design method, and relates to the technical field of gynecological tumor radiotherapy. The method comprises the following steps of: A100, filling a vaginal cavity, and acquiring intracavity and pelvic cavity data through CT (Computed Tomography); a200, the position Ti of a puncture target spot is determined, and a virtual puncture model is constructed; a300, modifying the CT data based on the virtual puncture model to enable a puncture path in the puncture model to be different from surrounding tissues, and exporting the modified CT data; a400, a final guide plate model is constructed according to the corrected CT data, and an implantation guide plate is manufactured through 3D printing; the problem that the puncture path of the gynecological tumor implantation guide plate is difficult to design scientifically is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of gynecological tumor radiotherapy, and in particular to a method for designing a puncture path of a gynecological tumor 3D printed implantation guide. Background Art

[0002] Implant radiotherapy uses a puncture needle to introduce the radiation source into the tumor target area, so that the tumor tissue itself receives a high dose of radiation, while the surrounding normal tissue receives a smaller dose. It is becoming more and more widely used in clinical tumor treatment. In recent years, with the maturity of 3D printing technology, the implant guide is customized according to the virtual puncture path pre-planned by the radiotherapy planning software, which further improves the accuracy of implant needle puncture.

[0003] Due to the limitations of radiotherapy planning software, the pre-planned virtual puncture path can only be arranged on the CT cross-section. However, the puncture path of gynecological tumors is in the head-to-foot direction (such as cervical cancer is usually punctured through the vagina), so it is impossible to formulate an ideal pre-plan for dose distribution.

[0004] For 3D printed implant guides for gynecological tumors, the direction of the puncture channel can only be "generally controlled" based on clinical experience, supplemented by a large number of spare channels for selection during treatment. Due to the lack of scientific design of the puncture needle channel, there is a large uncertainty in the dose distribution of the tumor target area, and the selection path from the spare channel will involve repeated "puncture and CT scanning", causing greater puncture and radiation damage.

[0005] Scientifically designing the puncture path and verifying its impact on dose distribution in the pre-planning stage have become key clinical pain points affecting the large-area application of 3D printed guides in guiding precision radiotherapy for gynecological tumors. Summary of the invention

[0006] The purpose of the present invention is to provide a 3D printed puncture path design method for a gynecological tumor implantation guide to solve the problem that it is difficult to scientifically design the puncture path of a gynecological tumor implantation guide.

[0007] In order to solve the above problems, the present invention adopts the following technical means: A gynecological tumor 3D printing implantation guide puncture path design method, comprising A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; A200. Determine the puncture target position Ti and construct a virtual puncture model; A300. Modify the CT data based on the virtual puncture model so that the puncture path in the puncture model differs from the surrounding tissue, and derive the corrected CT data; A400. The final guide model was constructed based on the corrected CT data, and the implantation guide was produced by 3D printing.

[0008] Preferably, the A100 comprises S100. Fill the vaginal cavity with flexible material and collect data of the cavity and pelvic area surface using CT scanning.

[0009] Furthermore, in S100, the flexible material is a material having a CT value significantly different from that of the inner wall of the vagina.

[0010] Furthermore, the A200 includes S200. The radiotherapy planning system re-delineates the tumor target area based on the CT data and determines the puncture target point position Ti; S300. Reconstructing a three-dimensional model of the vaginal wall and the pelvic skin based on the CT data, and designing the main structure of the implantation guide based on the three-dimensional model; S400. Arrange a virtual puncture needle based on the puncture position Ti and the main body structure.

[0011] Furthermore, in S200, the radiotherapy planning system includes one of Oncentra or Brachytherapy Planning.

[0012] Furthermore, in S300, the main structure includes an intracavitary filling structure and an extracorporeal fixing structure, the intracavitary filling structure is consistent with the shape of the vagina after filling, and the sharp parts are smoothed, and the extracorporeal fixing structure matches the contour of the perineum and is provided with a clinical observation hole and a catheter hole.

[0013] Furthermore, in S400, the path of the virtual puncture needle avoids the inner wall of the vagina, and the path of the virtual puncture needle should avoid crossing.

[0014] Furthermore, the A300 includes S500. According to the path of the virtual puncture needle, modify the CT value of the area where the puncture needle passes in the CT image, so that the CT value of the area where the puncture needle passes is significantly different from that of the surrounding tissue, and export the corrected CT data.

[0015] Furthermore, the A400 includes S600. Import the corrected CT data into the radiotherapy planning system, and outline the puncture path based on the difference between the CT value of the virtual puncture needle and the surrounding tissue; S700. Calculate the pre-plan corresponding to the current puncture path according to the tumor target distribution and the prescribed dose, and evaluate the impact of the target area, organs at risk, and normal tissue dose distribution. If the dose distribution does not meet the clinical requirements, the puncture target point position or the virtual puncture path should be adjusted and then evaluated.

[0016] S800. Subtracting the virtual puncture needle from the main structure of the implantation guide plate through Boolean operation to obtain a final guide plate model; S900. Make the implant guide using 3D printing based on the final guide model.

[0017] During use, the present invention has the following beneficial effects: In view of the problems that gynecological tumors are difficult to insert needles and to accurately determine the puncture channel due to their special locations, the present invention collects CT data, revises the CT data in a targeted manner, outputs a simulated puncture path, and can evaluate the rationality of the puncture path and the dose distribution of the tumor target area in the pre-planning stage, thereby realizing the scientific nature of the 3D printed guide plate puncture channel design, thereby achieving the purpose of reducing puncture and radiation damage and reducing the uncertainty of radiation dose distribution. DETAILED DESCRIPTION

[0018] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments.

[0019] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features of the embodiments may be combined with each other.

[0021] Example 1 A gynecological tumor 3D printing implantation guide puncture path design method, comprising A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; A200. Determine the puncture target position Ti and construct a virtual puncture model; A300. Modify the CT data based on the virtual puncture model so that the puncture path in the puncture model differs from the surrounding tissue, and derive the corrected CT data; A400. The final guide model was constructed based on the corrected CT data, and the implantation guide was produced by 3D printing.

[0022] In this embodiment, by collecting CT data and revising the CT data in a targeted manner, outputting a simulated puncture path, and being able to evaluate the rationality of the puncture path and the dose distribution of the tumor target area in the pre-planning stage, the scientific design of the 3D printed guide puncture channel is achieved, thereby achieving the purpose of reducing puncture and radiation damage and reducing the uncertainty of radiation dose distribution.

[0023] Example 2 In this embodiment, a gynecological tumor 3D printing implantation guide puncture path design method includes: A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; The method includes S100: filling the vaginal cavity with a flexible material, collecting the data of the cavity and the pelvic area surface by CT scanning, and the flexible material is selected to have a CT value significantly different from that of the inner wall of the vagina.

[0024] In this way, the flexible material is used to fill the vaginal cavity. On the one hand, it can avoid damage to the fragile inner wall of the vaginal cavity. On the other hand, it can also fill the vaginal cavity, thereby reflecting the data of the cavity channel in the CT data, and then fill the involved space. At the same time, the bending path of the inner wall of the vaginal cavity is reduced, which is convenient for the subsequent design of the virtual puncture needle.

[0025] A200. Determine the puncture target position Ti and construct a virtual puncture model; A300. Modify the CT data based on the virtual puncture model so that the puncture path in the puncture model differs from the surrounding tissue, and derive the corrected CT data; A400. The final guide model was constructed based on the corrected CT data, and the implantation guide was produced by 3D printing.

[0026] Example 3 In this embodiment, a gynecological tumor 3D printing implantation guide puncture path design method includes: A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; The method includes S100: filling the vaginal cavity with a flexible material, collecting the data of the cavity and the pelvic area surface by CT scanning, and the flexible material is selected to have a CT value significantly different from that of the inner wall of the vagina.

[0027] In this way, the flexible material is used to fill the vaginal cavity. On the one hand, it can avoid damage to the fragile inner wall of the vaginal cavity. On the other hand, it can also fill the vaginal cavity, thereby reflecting the data of the cavity channel in the CT data, and then fill the involved space. At the same time, the bending path of the inner wall of the vaginal cavity is reduced, which is convenient for the subsequent design of the virtual puncture needle.

[0028] A200. Determine the puncture target position Ti and construct a virtual puncture model; The method includes S200. outlining a tumor target area based on body surface data in a radiotherapy planning system, and determining a puncture position Ti; The radiation therapy planning systems here include Oncentra or Brachytherapy Planning.

[0029] Moreover, the number of tumor puncture targets is consistent with the number of puncture needles, and there are usually multiple puncture targets.

[0030] S300. Reconstructing a three-dimensional model of the vaginal wall and the pelvic skin based on the CT data, and designing the main structure of the implantation guide based on the three-dimensional model; The main structure here includes an intracavitary filling structure and an extracorporeal fixing structure. The intracavitary filling structure is consistent with the shape of the vagina after filling, and the sharp parts are smoothed. The extracorporeal fixing structure matches the contour of the perineum to play an installation limiting role, and is provided with a clinical observation hole and a catheter hole so as not to interfere with clinical observation and catheter installation.

[0031] S400. Arrange a virtual puncture needle based on the puncture position Ti and the main body structure and establish a virtual puncture model.

[0032] When setting the virtual puncture needle, its path needs to avoid the inner wall of the vagina, and near the tumor target area, the paths of the two virtual puncture needles are staggered. Specifically, except near the target area, the path of the virtual puncture needle should avoid the inner wall of the vagina. In addition, the distance between more than two implantation needle paths should be avoided to avoid interlacing and overlapping.

[0033] A300. Modify the CT data based on the virtual puncture model so that the puncture path in the puncture model differs from the surrounding tissue, and derive the corrected CT data; A400. The final guide model was constructed based on the corrected CT data, and the implantation guide was produced by 3D printing.

[0034] Example 4 In this embodiment, a gynecological tumor 3D printing implantation guide puncture path design method includes: A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; The method includes S100: filling the vaginal cavity with a flexible material, collecting the data of the cavity and the pelvic area surface by CT scanning, and the flexible material is selected to have a CT value significantly different from that of the inner wall of the vagina.

[0035] In this way, the flexible material is used to fill the vaginal cavity. On the one hand, it can avoid damage to the fragile inner wall of the vaginal cavity. On the other hand, it can also fill the vaginal cavity, thereby reflecting the data of the cavity channel in the CT data, and then fill the involved space. At the same time, the bending path of the inner wall of the vaginal cavity is reduced, which is convenient for the subsequent design of the virtual puncture needle.

[0036] A200. Determine the puncture target position Ti and construct a virtual puncture model; The method includes S200. outlining a tumor target area based on CT data in a radiotherapy planning system, and determining a puncture position Ti; The radiation therapy planning systems here include Oncentra or Brachytherapy Planning.

[0037] Moreover, the number of tumor puncture targets is consistent with the number of puncture needles, and there are usually multiple puncture targets.

[0038] S300. Reconstructing a three-dimensional model of the vaginal wall and the pelvic skin based on the CT data, and designing the main structure of the implantation guide based on the three-dimensional model; The main structure here includes an intracavitary filling structure and an extracorporeal fixing structure. The intracavitary filling structure is consistent with the shape of the vagina after filling, and the sharp parts are smoothed. The extracorporeal fixing structure matches the contour of the perineum to play an installation limiting role, and is provided with a clinical observation hole and a catheter hole so as not to interfere with clinical observation and catheter installation.

[0039] S400. Arrange a virtual puncture needle based on the puncture position Ti and the main body structure and establish a virtual puncture model.

[0040] When setting the virtual puncture needle, its path needs to avoid the inner wall of the vagina, and near the tumor target area, the paths of the two virtual puncture needles are staggered. Specifically, except near the target area, the path of the virtual puncture needle should avoid the inner wall of the vagina. In addition, the distance between more than two implantation needle paths should be avoided to avoid interlacing and overlapping.

[0041] A300. Modify the CT data based on the virtual puncture model so that the puncture path in the puncture model differs from the surrounding tissue, and derive the corrected CT data; It includes S500. According to the path of the virtual puncture model, the CT value of the area where the puncture needle passes in the CT image is modified so that the CT value of the area where the puncture needle passes is significantly different from that of the surrounding tissue, and the modified CT data is exported.

[0042] A400. The final guide model was constructed based on the corrected CT data, and the implantation guide was produced by 3D printing.

[0043] Specifically, it includes S600. Importing the corrected CT data into the radiotherapy planning system and outlining the puncture path; S700. Calculate the pre-plan corresponding to the current puncture path based on the tumor target distribution and the prescribed dose, and evaluate the impact of the dose distribution on the target area, organs at risk, and normal tissues.

[0044] S800. Subtracting the virtual puncture needle from the main structure of the implantation guide plate through Boolean operation to obtain a final guide plate model; S900. Make the implant guide using 3D printing based on the final guide model.

[0045] Example 5 In this embodiment, a gynecological tumor 3D printing implantation guide puncture path design method includes: A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; The method includes S100: filling the vaginal cavity with a flexible material, collecting the data of the cavity and the pelvic area surface by CT scanning, and the flexible material is selected to have a CT value significantly different from that of the inner wall of the vagina.

[0046] In this way, the flexible material is used to fill the vaginal cavity. On the one hand, it can avoid damage to the fragile inner wall of the vaginal cavity. On the other hand, it can also fill the vaginal cavity, thereby reflecting the data of the cavity channel in the CT data, and then fill the involved space. At the same time, the bending path of the inner wall of the vaginal cavity is reduced, which is convenient for the subsequent design of the virtual puncture needle.

[0047] A200. Determine the puncture target position Ti and construct a virtual puncture model; The method includes S200. outlining a tumor target area based on CT data in a radiotherapy planning system, and determining a puncture position Ti; The radiation therapy planning systems here include Oncentra or Brachytherapy Planning.

[0048] Moreover, the number of tumor puncture targets is consistent with the number of puncture needles, and there are usually multiple puncture targets.

[0049] S300. Reconstructing a three-dimensional model of the vaginal wall and the pelvic skin based on the CT data, and designing the main structure of the implantation guide based on the three-dimensional model; The main structure here includes an intracavitary filling structure and an extracorporeal fixing structure. The intracavitary filling structure is consistent with the shape of the vagina after filling, and the sharp parts are smoothed. The extracorporeal fixing structure matches the contour of the perineum to play an installation limiting role, and is provided with a clinical observation hole and a catheter hole so as not to interfere with clinical observation and catheter installation.

[0050] S400. Arrange a virtual puncture needle based on the puncture position Ti and the main body structure and establish a virtual puncture model.

[0051] When setting the virtual puncture needle, its path needs to avoid the inner wall of the vagina, and near the tumor target area, the paths of the two virtual puncture needles are staggered. Specifically, except near the target area, the path of the virtual puncture needle should avoid the inner wall of the vagina. In addition, the distance between more than two implantation needle paths should be avoided to avoid interlacing and overlapping.

[0052] A300. In the 3D reconstruction and guide plate design software, the corresponding coordinates are output on the virtual puncture model according to the path of the implant needle.

[0053] In order to simplify the setting, the aforementioned coordinate data can only export the coordinate data of the two ends of the implant needle to facilitate the subsequent delineation of the puncture path.

[0054] A400. Build the final guide model and make the implant guide by 3D printing.

[0055] Specifically, it includes S600. outlining a puncture path according to the coordinate data derived above; S700. Calculate the pre-plan corresponding to the current puncture path based on the tumor target distribution and the prescribed dose, and evaluate the impact of the dose distribution on the target area, organs at risk, and normal tissues.

[0056] S800. Subtracting the virtual puncture needle from the main structure of the implantation guide plate through Boolean operation to obtain a final guide plate model; S900. Make the implant guide using 3D printing based on the final guide model.

[0057] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A gynecological tumor 3D printing implantation guide puncture path design method, characterized in that: include A100. Fill the vaginal cavity and collect cavity and pelvic cavity data through CT; A200. Determine the puncture target position Ti and construct a virtual puncture model; A300. Modify the CT data based on the virtual puncture model so that the puncture path in the puncture model differs from the surrounding tissue, and derive the corrected CT data; A400. The final guide model was constructed based on the corrected CT data, and the implantation guide was produced by 3D printing.

2. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 1, characterized in that: The A100 includes S100. Fill the vaginal cavity with flexible material and collect data of the cavity and pelvic area surface using CT scanning.

3. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 2, characterized in that: In the above S100, the flexible material is a material having a CT value significantly different from that of the inner wall of the vagina.

4. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 1, characterized in that: The A200 includes S200. Outlining the tumor target area based on the CT image data in the radiotherapy planning system, and determining the puncture target point position Ti; S300. Reconstructing a three-dimensional model of the vaginal wall and the pelvic skin based on the CT data, and designing the main structure of the implantation guide based on the three-dimensional model; S400. Arrange a virtual puncture needle based on the puncture target point position Ti and the main body structure.

5. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 4, characterized in that: In S200, the radiotherapy planning system includes one of Oncentra and Brachytherapy Planning.

6. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 4, characterized in that: In S300, the main structure includes an intracavitary filling structure and an extracorporeal fixing structure. The intracavitary filling structure is consistent with the shape of the vagina after filling, and the sharp parts are smoothed. The extracorporeal fixing structure matches the contour of the perineum and is provided with a clinical observation hole and a catheter hole.

7. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 4, characterized in that: In S400, the path of the virtual puncture needle avoids the inner wall of the vagina.

8. The method for designing a 3D printed implantation guide puncture path for gynecological tumors according to claim 1, characterized in that: The A300 includes S500. According to the path of the virtual puncture needle, the CT value of the area where the puncture needle passes in the CT image data is modified layer by layer, so that the CT value of the area where the puncture needle passes is significantly different from that of the surrounding tissue, and the corrected CT data is exported.

9. A gynecological tumor 3D printing implantation guide puncture path design method according to claim 1, characterized in that: The A400 includes S600. Import the corrected CT data into the radiotherapy planning system, and outline the puncture path based on the difference between the CT value of the virtual puncture needle and the surrounding tissue; S700. Calculate the pre-plan corresponding to the current puncture path based on the tumor target distribution and the prescribed dose, and evaluate the impact of the dose distribution on the target area, organs at risk, and normal tissues.

10. S800. Subtract the virtual puncture needle from the main structure of the implantation guide through Boolean operation to obtain the final guide model; S900. Make the implant guide using 3D printing based on the final guide model.