Vitamin B1 with high bioavailability and preparation method thereof

Abstract

The invention discloses high-bioavailability vitamin B1 and a preparation method thereof. The high-bioavailability vitamin B1 comprises vitamin B1, a sustained-release and controlled-control framework material, a coating material, an emulsifier, an acidity regulator, a thickener and an auxiliary material. The preparation method comprises the following steps: mixing the solid-phase vitamin B1, the auxiliary material, the thickening agent and the acidity regulator with the liquid-phase water, heating for dissolving, stirring and homogenizing, and spraying and drying while stirring to obtain an intermediate product; then wrapping the prepared intermediate product by adopting a dissolved coating material and an emulsifying agent in an extruding and rounding manner, and finally mixing with auxiliary materials to obtain the high-bioavailability vitamin B1. The product provided by the invention is a product with high bioavailability by adopting a granulation mode or an extrusion-rolling mode. Through formula design, a sustained-release material and a coating material are combined, so that a product which is uniform in mixing, stable in shelf life, high in gastric acid passing rate and less in small intestine damage is obtained.

Description

Technical Field

[0001] The invention relates to the technical field of development of food, functional food and health food, and more specifically to vitamin B1 with high bioavailability and a preparation method thereof. Background Art

[0002] Vitamin B1 (thiamine hydrochloride), including thiamine hydrochloride and thiamine nitrate, as an important nutritional enhancer, can be used to enhance products in various market segments, such as health food tablets, pharmaceutical tablets, capsules, milk powder, solid beverages, special medical products, etc.

[0003] Vitamin B1 (thiamine hydrochloride) is not heat-resistant and alkali-resistant, but it is less affected by light and humidity. Based on the above characteristics, it is easy to decompose in alkaline products or under high heat in the processing process, resulting in unqualified vitamin B1 (thiamine hydrochloride) content in the product. At present, the mainstream tablet types in the food industry are mostly calcium and magnesium supplements, such as tablets based on calcium carbonate or magnesium oxide, etc., but calcium carbonate and magnesium oxide in this type of tablets are both alkaline raw materials. In the composition of tablet pressing, extrusion will also generate heat, which accelerates the contact between vitamin B1 (thiamine hydrochloride) and alkaline elements. Under the action of material moisture, sulfate (pseudo-base) is produced through reaction, and then sulfate (thiol state) is produced, which is then decomposed into multiple cracking products such as sulfur and hydrogen sulfide under alkaline and heat conditions. How to solve the impact on vitamin B1 (thiamine hydrochloride) under alkaline conditions is an important issue. Summary of the invention

[0004] In view of this, the present invention provides a vitamin B1 with high bioavailability and a preparation method thereof, which adopts the following technical scheme:

[0005] First, a vitamin B1 with high bioavailability is provided, which includes the following components in weight percentage: vitamin B1 0.01%-90%, sustained-release controlled skeleton material 1%-99%, coating material 0.1%-50%, emulsifier 1%-99%, acidity regulator 0.1%-50%, thickener 1%-99%, and auxiliary material 1%-99%.

[0006] Preferably, the sustained-release controlled skeleton material is a water-soluble material, polyoxyethylene.

[0007] Preferably, the coating material is glyceryl mono- and distearate; the emulsifier is glyceryl mono- and disolaurate; the acidity regulator is a citric acid and sodium citrate system; the thickener is gum arabic; and the auxiliary material is one or more of maltodextrin and corn starch.

[0008] Furthermore, in the citric acid and sodium citrate system, the mass ratio of citric acid: sodium citrate is 1:2.

[0009] The present invention also provides a method for preparing vitamin B1 with high bioavailability as described in the above technical solution, comprising the following steps:

[0010] (1) mixing solid vitamin B1, 4 / 5 of the auxiliary materials, a thickener, and an acidity regulator with liquid water, heating to dissolve, stirring to homogenize, and spray drying while stirring to obtain an intermediate product;

[0011] (2) heating and dissolving the coating material and emulsifier for later use;

[0012] (3) using the solution obtained in step (2) to wrap the intermediate product obtained in step (1) by extrusion and spheronization to obtain a wrapped product, wherein the extrusion speed is 0-600 r / min, the spheronization speed is 0-1500 r / min, and the spheronization time is 0-20 min;

[0013] (4) The encapsulated product prepared in step (3) is mixed with the remaining auxiliary materials to obtain vitamin B1 with high bioavailability.

[0014] Preferably, in step (1), the weight ratio of solid phase:liquid phase is 1:2, and the heating temperature is 50-55°C.

[0015] Preferably, the spray drying in step (1) has an air inlet temperature of 150°C and an air outlet temperature of 80-85°C.

[0016] Preferably, the heating in step (2) is water bath heating at a heating temperature of 60-100°C.

[0017] Preferably, in step (3), the weight ratio of the intermediate product to the solution is 1:2.

[0018] Preferably, three-dimensional mixing or cone mixing is adopted in step (4), wherein the three-dimensional mixing speed is 10 r / min, the mixing time is 18 min, and the cone mixing is 15 min.

[0019] It can be seen from the above technical solution that, compared with the prior art, the present invention discloses a vitamin B1 with high bioavailability and a preparation method thereof, which has the following beneficial effects:

[0020] The product of the present invention adopts a combination of granulation or extrusion spheronization to produce a product with high bioavailability. Through the design of the formula, the combination of sustained-release controlled materials and coating materials is adopted to achieve a product with uniform mixing, stable shelf life, high gastric acid passing rate, and less small intestine damage. The process combination of this product realizes the combination of different modern granulation equipment, and multiple process combinations can be used. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0022] Figure 1 This is a static gastric simulation data diagram;

[0023] Figure 2 The concentration change diagram of VB1 in blood after supplementing 30 mg of conventional VB1 and the VB1 product produced by the method of the present invention;

[0024] Figure 3 This is a conventional VB1 micrograph;

[0025] Figure 4-5 This is an electron micrograph of spray-dried vitamin B1 (thiamine hydrochloride);

[0026] Figure 6 Extruded and rolled vitamin B1 (thiamine hydrochloride). DETAILED DESCRIPTION

[0027] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Example 1

[0029] Preparation method of vitamin B1 (thiamine hydrochloride) with high bioavailability (taking 300 kg of production as an example):

[0030] (1) dissolving 60 kg of solid vitamin B1 (thiamine hydrochloride), 200 kg of maltodextrin, 30 kg of corn starch, 19 kg of gum arabic, 6 kg of sodium citrate, 3 kg of citric acid and liquid water (weight ratio solid: liquid = 1:2) at 50-55° C., stirring homogenously, and spray drying (inlet air 150° C., outlet air 80-85° C.) while stirring, and spray drying to obtain an intermediate product;

[0031] (2) Dissolve 15 kg of glyceryl mono- and distearate in 60-100° C. water in a water bath for later use;

[0032] (3) using 15 kg of the solution of step (2) to wrap 234 kg of the intermediate product obtained in step (1) by extrusion and spheronization, with an extrusion speed of 300 r / min, a spheronization speed of 400 r / min, and a spheronization time of 10 min to obtain a product;

[0033] (4) The product obtained in step (3) was three-dimensionally mixed with 50 kg of corn starch (1500 L silo, rotation speed 10 rpm, mixing time 18 min) or cone mixed for 15 min to obtain 300 kg of highly bioavailable vitamin B1.

[0034] Data 1. Acceleration Data

[0035] Tablet manufacturing process:

[0036] According to the ratio of calcium carbonate to VB1=62.5:37.5, calcium carbonate and VB1 were mixed three-dimensionally (50L silo, rotation speed 10 rpm, mixing time 18 min), passed through a 40-mesh sieve, tableted, and packaged in aluminum foil bags. The mixture was kept at a constant temperature and humidity of 37°C ± 2°C and a humidity of 75% for 6 months.

[0037] Calcium tablets shelf life tablet decay (accelerated 6 months)

[0038]

[0039] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0040] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A vitamin B1 with high bioavailability, characterized in that: The invention comprises the following components in weight percentage: 0.01%-90% of vitamin B1, 1%-99% of a sustained-release controlled skeleton material, 0.1%-50% of a coating material, 1%-99% of an emulsifier, 0.1%-50% of an acidity regulator, 1%-99% of a thickener, and 1%-99% of an auxiliary material.

2. A vitamin B1 with high bioavailability according to claim 1, characterized in that: The skeleton material of the sustained-release controlled substance is a water-based material, polyoxyethylene.

3. The vitamin B1 with high bioavailability according to claim 1, characterized in that: The coating material is glyceryl mono- and distearate; the emulsifier is glyceryl mono- and dislaurate; the acidity regulator is a citric acid and sodium citrate system; the thickener is gum arabic; and the auxiliary material is one or more of maltodextrin and corn starch.

4. The vitamin B1 with high bioavailability according to claim 1, characterized in that: The mass ratio of citric acid to sodium citrate in the citric acid and sodium citrate system is 1:

2.

5. A method for preparing the vitamin B1 with high bioavailability according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) mixing solid vitamin B1, 4 / 5 of the auxiliary materials, a thickener, and an acidity regulator with liquid water, heating to dissolve, stirring to homogenize, and spray drying while stirring to obtain an intermediate product; (2) heating and dissolving the coating material and emulsifier for later use; (3) using the solution obtained in step (2) to wrap the intermediate product obtained in step (1) by extrusion and spheronization to obtain a wrapped product, wherein the extrusion speed is 0-600 r / min, the spheronization speed is 0-1500 r / min, and the spheronization time is 0-20 min; (4) The encapsulated product prepared in step (3) is mixed with the remaining auxiliary materials to obtain vitamin B1 with high bioavailability.

6. The method for preparing vitamin B1 with high bioavailability according to claim 5, characterized in that: In step (1), the weight ratio of solid phase:liquid phase is 1:2, and the heating temperature is 50-55°C.

7. The method for preparing vitamin B1 with high bioavailability according to claim 5, characterized in that: The spray drying in step (1) has an air inlet temperature of 150°C and an air outlet temperature of 80-85°C.

8. The method for preparing vitamin B1 with high bioavailability according to claim 5, characterized in that: The heating in step (2) is water bath heating at a temperature of 60-100°C.

9. The method for preparing vitamin B1 with high bioavailability according to claim 5, characterized in that: In step (3), the weight ratio of the intermediate product to the solution is 1:

2.

10. The method for preparing vitamin B1 with high bioavailability according to claim 5, characterized in that: In step (4), three-dimensional mixing or cone mixing is adopted, wherein the three-dimensional mixing speed is 10 r / min, the mixing time is 18 min, and the cone mixing is 15 min.

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