Ablation control method, system and device, computer equipment and storage medium

Abstract

The invention relates to an ablation control method, system and device, computer equipment, a computer readable storage medium and a computer program product. The method comprises the following steps: acquiring ablation input power corresponding to a to-be-ablated area; an ablation signal is provided for the target electrode so as to apply ablation energy to the to-be-ablated area, and the initial power of the ablation signal is smaller than the ablation input power; in the process of applying ablation energy to the to-be-ablated area, physiological parameters are obtained. Target output power of ablation energy corresponding to the ablation signal is determined according to the physiological parameters, the ablation input power and the ablation progress, the influence degree of the physiological parameters on the target output power is in negative correlation with the ablation progress, and the influence degree of the ablation input power on the target output power is in positive correlation with the ablation progress. The power of the ablation signal is adjusted. By the adoption of the method, the sympathetic nerves in the to-be-ablated area can be ablated on the premise that the nerve fibers are prevented from being irreversibly damaged in the ablation process.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to an ablation control method, system, device, computer equipment, computer-readable storage medium, and computer program product. Background Art

[0002] With the development of medical technology, minimally invasive ablation technology has emerged. A small incision is made in the epidermis of the subject, and then an electrode needle is inserted into the subject's body to reach the location of the subject's lesion tissue. Then, the lesion tissue of the subject is ablated by the high-voltage pulse generated between the electrodes, thereby achieving the purpose of removing the lesion tissue of the subject. Overactive nerves can have adverse effects on human organs or tissues, leading to a series of cardiovascular diseases. For example, chronic overactivation of the sympathetic nerves can cause excessive secretion of renin, increased sodium ion reabsorption levels in the kidneys, increased cardiac output, and ultimately increased blood pressure. If this vicious cycle is not controlled, it will eventually lead to high-risk cardiovascular events such as heart failure and stroke. Although there are many different types of treatments for hypertension, in my country, less than 15% of patients can receive long-term systematic treatment, and only 5% of patients can control their blood pressure. Therefore, there is still a need for a treatment plan that can effectively help hypertensive patients control their blood pressure in the long term.

[0003] Currently, a method has been proposed to treat pulmonary hypertension by performing radiofrequency ablation on the pulmonary artery through a radiofrequency ablation catheter, namely renal sympathetic denervation or RDN surgery. This surgery blocks the autonomic nervous system around the pulmonary artery through radiofrequency heating, reduces the sympathetic nerve tension, and thus achieves a long-term therapeutic effect of lowering blood pressure. The principle is to ablate the sympathetic nerve fibers around the renal artery and reduce the sympathetic nerve tension around the kidney, thereby increasing the glomerular filtration rate, reducing the renal reabsorption capacity, and reducing the reabsorption of sodium ions and water, thereby achieving a decrease in blood pressure.

[0004] The known RDN surgery is to reach the bilateral renal arteries through the femoral artery through a catheter, and release radiofrequency, ultrasound or radiation energy in the selected area by controlling the electrodes on the catheter, so that the renal artery intima produces local high temperature to block the conduction function of some sympathetic nerve fibers on the renal artery wall. RDN strategies based on renal artery anatomy have been proposed, which improve the surgical treatment effect through special catheter design and increased treatment of the distal branches of the renal artery. However, this method still has the following problems: (i) Clinical studies have shown that increasing the number of ablations is not enough to produce a clear relationship with the tissue content of renal norepinephrine, and the relationship between the selection of ablation segments and the antihypertensive effect has not yet been clarified; (ii) Basic research has shown that while the kidneys are innervated by sympathetic and sensory nerves, there are also some nerve fibers that inhibit sympathetic nerve activity, such as parasympathetic nerves, and differentiated treatment of nerve fibers cannot be achieved by segment selection alone.

[0005] Therefore, ablation surgery using traditional techniques cannot provide differentiated treatment based on the state and distribution of nerve fibers, so it is not safe enough and can easily cause unnecessary damage to the subject. Summary of the invention

[0006] Based on this, it is necessary to provide an ablation control method, system, device, computer equipment, computer-readable storage medium, and computer program product that are safer and can adaptively adjust the ablation power according to the physiological parameters of the object to address the above technical problems.

[0007] An ablation control method comprises: obtaining an ablation input power corresponding to an area to be ablated; providing an ablation signal to a target electrode to control the target electrode to apply ablation energy to the area to be ablated, wherein the initial power of the ablation energy is less than the ablation input power; in the process of applying ablation energy to the area to be ablated, obtaining physiological parameters, wherein the physiological parameters are physiological parameters of an object acted upon by the target electrode; determining a target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and ablation progress, wherein the degree of influence of the physiological parameters on the target output power decreases as the ablation progresses, and the degree of influence of the ablation input power on the target output power increases as the ablation progresses.

[0008] In one of the embodiments, determining the target output power of the ablation energy corresponding to the ablation signal based on the physiological parameters, the ablation input power and the ablation progress includes: obtaining the actual physiological parameters of the target electrode's target object and the corresponding target physiological parameters; determining the error amount of the physiological parameters during the ablation process based on the actual physiological parameters and the target physiological parameters; respectively obtaining a first influencing factor of the physiological parameters affecting the target output power and a second influencing factor of the ablation input power affecting the target output power; wherein the size of the first influencing factor is negatively correlated with the ablation progress, and the size of the second influencing factor is positively correlated with the ablation progress; determining the target output power of the ablation energy corresponding to the ablation signal based on the error amount, the first influencing factor, the ablation input power and the second influencing factor.

[0009] In one embodiment, the target output power of the ablation energy corresponding to the ablation signal is determined based on the error amount, the first influencing factor, the ablation input power, and the second influencing factor, including: determining the first power based on the product of the error amount and the first influencing factor; determining the second power based on the product of the ablation input power and the second influencing factor; and determining the target output power of the ablation energy corresponding to the ablation signal based on the sum of the first power and the second power.

[0010] In one embodiment, the ablation control method further includes: obtaining the changing trend of the physiological parameters during the ablation process; determining whether to stop providing the ablation signal to the target electrode based on the changing trend of the physiological parameters, the target output power, and the ablation time corresponding to the current ablation progress.

[0011] In one of the embodiments, the determination of whether to stop providing the ablation signal to the target electrode is made based on the changing trend of the physiological parameters, the target output power, and the ablation time corresponding to the current ablation progress, including: determining the total ablation energy cumulatively applied to the area to be ablated based on the target output power and the ablation time; stopping providing the ablation signal to the target electrode when the total ablation energy reaches a first threshold and the physiological parameters do not show an upward trend; and / or stopping providing the ablation signal to the target electrode when the changing trend of the physiological parameters conforms to a preset changing trend and the total ablation energy reaches a second threshold.

[0012] In one of the embodiments, the ablation control method further includes: when the ablation duration corresponding to the current ablation progress reaches a set duration, stopping providing the ablation signal to the target electrode.

[0013] In one of the embodiments, adjusting the power of the ablation energy corresponding to the ablation signal according to the determined target output power includes: in the process of providing the ablation signal to the target electrode, obtaining the actual power of the ablation signal output by the target electrode; and feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual power and the target output power so that the actual power reaches the target output power.

[0014] In one of the embodiments, the ablation control method further includes: acquiring the actual temperature of the area to be ablated during the process of providing the ablation signal to the target electrode; and stopping providing the ablation signal to the target electrode when the actual temperature is greater than a third threshold.

[0015] In one of the embodiments, adjusting the power of the ablation energy corresponding to the ablation signal according to the determined target output power includes: acquiring the actual temperature of the area to be ablated during the process of providing the ablation signal to the target electrode; and feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature so that the actual temperature reaches the target temperature, wherein the target temperature corresponds to the target output power.

[0016] In one of the embodiments, the ablation control method further includes: in the process of feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature, when the target output power is greater than the power limit, if the power of the ablation energy corresponding to the adjusted ablation signal is greater than the power limit, then the power of the ablation energy corresponding to the ablation signal provided to the target electrode is set to the power limit.

[0017] An ablation control system, comprising:

[0018] An electrode assembly, comprising a catheter and at least one electrode spaced apart on the catheter;

[0019] an ablation module, connected to the at least one electrode, for providing an ablation signal to a target electrode, wherein the target electrode is one of the at least one electrode;

[0020] A detection module, used for obtaining physiological parameters of an object acted upon by the target electrode;

[0021] A control module is respectively connected to the ablation module and the detection module, and is used to obtain the ablation input power corresponding to the area to be ablated, control the ablation module to provide an ablation signal to the target electrode, so as to control the target electrode to apply ablation energy to the area to be ablated, and in the process of providing the ablation signal to the target electrode, obtain the physiological parameters, and determine the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress; and control the ablation module to adjust the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the determined target output power, wherein the initial power of the ablation energy is less than the ablation input power, the degree of influence of the physiological parameters on the target output power decreases as the ablation progresses, and the degree of influence of the ablation input power on the target output power increases as the ablation progresses.

[0022] In one embodiment, the ablation control system further includes: a temperature sensor, which is arranged on the catheter and is used to collect the temperature of the area to be ablated; an acquisition module, which is respectively connected to the temperature sensor and the control module, and is used to obtain the temperature of the area to be ablated and transmit it to the control module; the control module is also used to control the ablation module to stop providing an ablation signal to the target electrode when the temperature of the area to be ablated is greater than a set temperature.

[0023] An ablation control device, comprising:

[0024] A power acquisition module, used to acquire the ablation input power corresponding to the area to be ablated;

[0025] an output module, configured to provide an ablation signal to a target electrode, so as to control the target electrode to apply ablation energy to the area to be ablated, wherein the initial power of the ablation energy is less than the ablation input power;

[0026] A parameter acquisition module, used for acquiring physiological parameters in the process of applying ablation energy to the area to be ablated, wherein the physiological parameters are physiological parameters of the object of action of the target electrode;

[0027] A power determination module, used to determine the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress, wherein the influence of the physiological parameters on the target output power decreases as the ablation progresses, and the influence of the ablation input power on the target output power increases as the ablation progresses;

[0028] The regulating module is used to regulate the power of the ablation energy corresponding to the ablation signal according to the determined target output power.

[0029] In one embodiment, a computer device is provided, including a memory and a processor, wherein the memory stores a computer program, and the processor implements the aforementioned ablation control method when executing the computer program.

[0030] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the ablation control method described above is implemented.

[0031] In one of the embodiments, a computer program product is provided, wherein the computer program product comprises a computer program, and when the computer program is executed by a processor, the ablation control method described above is implemented.

[0032] The above-mentioned ablation control method, system, device, computer equipment, computer-readable storage medium, and computer program product. The method first obtains the ablation input power corresponding to the area to be ablated, that is, obtains the reference rated power required to ablate the area to be ablated. The ablation input power can be directly input by the doctor, and then provides an ablation signal to the target electrode, so that the ablation energy is applied to the area to be ablated through the target electrode, which can achieve ablation and removal of the area to be ablated, and the initial power of the ablation signal is less than the ablation input power, that is, the power of the ablation energy corresponding to the ablation signal at the beginning is very small, and the effect of ablation and removal cannot be achieved, but the damage to the area to be ablated is also very small, which is to facilitate the subsequent gradual adjustment of the power of the ablation energy corresponding to the ablation signal according to the physiological parameters, so as to avoid the ablation energy corresponding to the ablation signal at the beginning. The power is too large and causes irreversible damage to the object. Then, in the process of applying ablation energy to the area to be ablated, the physiological parameters are obtained. Then, according to the physiological parameters, ablation input power and ablation progress, the target output power of the ablation energy corresponding to the ablation signal is comprehensively determined. In the process of determining the target output power, the influence of the physiological parameters on the target output power is negatively correlated with the ablation progress, and the influence of the ablation input power on the target output power is positively correlated with the ablation progress. Therefore, in the early stage of applying ablation energy to the area to be ablated, the target output power of the ablation energy corresponding to the ablation signal is mainly determined by the physiological parameters, which enables the target output power of the ablation energy corresponding to the ablation signal to be adjusted according to the physiological parameters, so as to correspond to the current state of the area to be ablated, that is, the target output power is matched with the patient's real-time physiological parameters, so that the power of the ablation energy corresponding to the ablation signal can just achieve the effect of ablation and removal, and can avoid irreversible damage to the nerves in the area to be ablated due to excessive power. As the ablation progresses, the target output power will converge toward the ablation input power input by the doctor, and finally converge to the vicinity of the ablation input power to ensure the ablation effect. In summary, the method of the present application can adaptively adjust the power of the ablation energy corresponding to the ablation signal according to the patient's physiological parameters during the ablation process, and ablate the sympathetic nerves in the ablation area while avoiding irreversible damage to the nerve fibers during the ablation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0034] Figure 1 is a flow chart of an ablation control method in one embodiment;

[0035] Figure 2 It is a flow chart of a method for determining a target output power of ablation energy corresponding to an ablation signal in one embodiment;

[0036] Figure 3 is a schematic diagram of a blood pressure curve in one embodiment;

[0037] Figure 4 is a flow chart of a method for calculating target output power in one embodiment;

[0038] Figure 5 is a schematic diagram of an ablation power curve in one embodiment;

[0039] Figure 6 is a schematic diagram of an ablation power curve in one embodiment;

[0040] Figure 7 is a schematic diagram of an ablation power curve in one embodiment;

[0041] Figure 8 A schematic flow chart of a method for stopping ablation in one embodiment;

[0042] Fig. 9 is a flow chart of a method for determining whether to stop ablation in one embodiment;

[0043] Fig.10 A schematic diagram of a flow chart of a method for adjusting power in one embodiment;

[0044] Fig.11 is a flow chart of a method for determining whether to stop ablation in another embodiment;

[0045] Fig.12 A schematic flow chart of a method for adjusting power in another embodiment;

[0046] Fig.13 is a schematic flow chart of a power regulation process in one embodiment;

[0047] Fig.14 is a schematic structural diagram of an ablation control system in one embodiment;

[0048] Fig.15 is a schematic structural diagram of an ablation control system in another embodiment;

[0049] Fig.16 is a schematic structural diagram of an ablation control device in one embodiment;

[0050] Fig.17 FIG. 4 is a diagram showing the internal structure of a computer device in one embodiment.

[0051] Description of reference numerals:

[0052] 11-electrode, 12-catheter, 20-ablation module, 30-detection module, 40-control module, 50-temperature sensor, 60-acquisition module. DETAILED DESCRIPTION

[0053] In order to facilitate understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. Embodiments of the present application are provided in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0054] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0055] It can be understood that the terms "first", "second", etc. used in the present application can be used in this article to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish the first element from another element.

[0056] It should be noted that when an element is considered to be "connected" to another element, it can be directly connected to the other element, or connected to the other element through an intermediate element. In addition, the "connection" in the following embodiments should be understood as "electrical connection", "communication connection", etc. if there is transmission of electrical signals or data between the connected objects.

[0057] When used herein, the singular forms "a", "an", and "said / the" may also include plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "include / comprise" or "have" and the like specify the presence of stated features, wholes, steps, operations, components, parts, or combinations thereof, but do not exclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts, or combinations thereof. At the same time, the term "and / or" used in this specification includes any and all combinations of the relevant listed items.

[0058] In one embodiment, Figure 1 As shown, an ablation control method is provided, which includes steps S100-S140.

[0059] Step S100, obtaining the ablation input power corresponding to the area to be ablated.

[0060] Specifically, the ablation input power may be a power directly input by a doctor, that is, a power that can achieve a better ablation effect based on accumulated experience or surgical requirements.

[0061] Step S110: providing an ablation signal to the target electrode to control the target electrode to apply ablation energy to the area to be ablated.

[0062] Specifically, the area to be ablated is an area located in the patient's body. Usually, a catheter with electrodes on it is used to enter the patient's body so that the electrodes can reach the area to be ablated. The target electrode is an electrode that releases ablation energy. The electrode is a device that can output energy. When an ablation signal is provided to the electrode, the electrode can release ablation energy near its setting position to achieve the ablation effect. The ablation energy is released at the position where the target electrode is located, so as to ablate the nerves that need to be ablated in the ablation area.

[0063] Among them, the initial power of the ablation energy corresponding to the ablation signal is less than the ablation input power. The ablation signal can be high-power ablation energy, and its unit is watt. High-power ablation energy refers to energy that can cause destructive damage to cells in a specific part and cause their death when acting on a specific part. Exemplarily, the output power of the ablation energy can be 0-40W, which is adjusted as needed, and the power of the ablation energy corresponding to the ablation signal in the present application gradually increases with the progress of ablation. The initial ablation power can be 0-5W, and its power is particularly small, so it will not cause damage to nerve fibers, avoiding the use of too large ablation power at the beginning, because it does not require such a large power to achieve ablation of the sympathetic nerves in the area to be ablated, so excessive ablation power will damage nerve fibers. For example, to achieve ablation of the sympathetic nerves in the area to be ablated, only an ablation signal with an ablation power of 10W is needed. By adopting the solution of the present application, the initial ablation power can be adjusted to 0-5W, and then gradually increased to 10W, to achieve ablation of the sympathetic nerves. At the same time, the ablation power will not be too large, so the damage to the nerve fibers is small. If the traditional method is adopted, for example, directly using an ablation signal with an ablation power of 30W for ablation, although the ablation effect can be achieved, it will also cause irreversible damage to the nerve fibers.

[0064] Step S120, obtaining physiological parameters during the process of applying ablation energy to the area to be ablated.

[0065] The physiological parameters are physiological parameters of the object of the target electrode.

[0066] Specifically, during the process of applying ablation energy to the area to be ablated, the physiological parameters of the subject will change. This is because the area to be ablated is stimulated by the ablation energy, and the stimulation of the area to be ablated can be reflected by the physiological parameters. Therefore, the physiological parameters of the subject can reflect the effect of ablation and the power of ablation to a certain extent. For example, ablation energy will generate heat, thereby increasing the tension of nerves in the area to be ablated, activating endocrine changes and thus affecting blood pressure changes.

[0067] Step S130, determining the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress.

[0068] Among them, the influence of physiological parameters on target output power is negatively correlated with the ablation progress, and the influence of ablation input power on target output power is positively correlated with the ablation progress. That is, the influence of physiological parameters on target output power decreases with the progress of ablation, and the influence of ablation input power on target output power increases with the progress of ablation.

[0069] Specifically, the target output power of the ablation energy corresponding to the ablation signal can be determined based on the physiological parameters and the ablation input power, combined with the ablation duration corresponding to the ablation progress. In the early stage of ablation, the target output power is mainly determined by the physiological parameters, so that in the early stage of ablation, the ablation power corresponds to the physiological parameters, which enables the target output power of the ablation energy corresponding to the ablation signal to be adjusted according to the physiological parameters, so that the power of the ablation energy corresponding to the ablation signal can just achieve the effect of ablation and clearance, and can avoid irreversible damage to the nerves in the ablation area due to excessive power. As the ablation progresses, in order to ensure the effect of ablation, the target output power will converge to the ablation input power input by the doctor, and finally converge to the vicinity of the ablation input power. This is because the ablation input power input by the doctor is usually correct. The ablation power in this scheme gradually rises with the progress of ablation to the vicinity of the ablation input power. Compared with directly using such a large ablation signal with ablation input power, a certain reaction and buffer time can be reserved. In the process of the ablation power converging to the vicinity of the ablation input power, the ablation power can be adjusted in time based on the patient's real-time physiological parameters to ensure that the ablation signal will not cause irreversible damage to tissues that do not need ablation. Improve the safety and accuracy of ablation and reduce damage to patients.

[0070] Step S140: adjusting the power of the ablation energy corresponding to the ablation signal according to the determined target output power.

[0071] Specifically, after determining the target output power, the power of the ablation energy corresponding to the current ablation signal will be adjusted to the target output power. The target output power is determined in real time based on physiological parameters, so the power of the ablation energy corresponding to the ablation signal will also be adjusted in real time as the ablation progresses.

[0072] In this embodiment, the ablation input power corresponding to the area to be ablated is first obtained, that is, the reference rated power required to ablate the area to be ablated is obtained. The ablation input power can be directly input by the doctor, and then an ablation signal is provided to the target electrode, so that ablation energy is applied to the area to be ablated through the target electrode, and ablation and removal of the area to be ablated can be achieved. In addition, the initial power of the ablation signal is less than the ablation input power, that is, the power of the ablation energy corresponding to the ablation signal at the beginning is very small, and the effect of ablation and removal cannot be achieved, but the damage to the area to be ablated is also very small. This is to facilitate the subsequent gradual adjustment of the power of the ablation energy corresponding to the ablation signal according to the physiological parameters, so as to avoid the ablation energy corresponding to the ablation signal at the beginning being too large and causing irreversible damage to the target. Then, in the process of applying ablation energy to the area to be ablated, the physiological parameters are obtained. Then, according to the physiological parameters, ablation input power and ablation progress, the target output power of the ablation energy corresponding to the ablation signal is comprehensively determined. In the process of determining the target output power, the influence of the physiological parameters on the target output power is negatively correlated with the ablation progress, and the influence of the ablation input power on the target output power is positively correlated with the ablation progress. Therefore, in the early stage of applying ablation energy to the area to be ablated, the target output power of the ablation energy corresponding to the ablation signal is mainly determined by the physiological parameters, which enables the target output power of the ablation energy corresponding to the ablation signal to be adjusted according to the physiological parameters, so as to correspond to the current state of the area to be ablated, that is, the target output power is matched with the patient's real-time physiological parameters, so that the power of the ablation energy corresponding to the ablation signal can just achieve the effect of ablation and removal, and can avoid irreversible damage to the nerves in the area to be ablated due to excessive power. As the ablation progresses, the target output power will converge toward the ablation input power input by the doctor, and finally converge to the vicinity of the ablation input power to ensure the ablation effect. In summary, the method of the present application can adaptively adjust the power of the ablation energy corresponding to the ablation signal according to the patient's physiological parameters during the ablation process, and ablate the sympathetic nerves in the ablation area while avoiding irreversible damage to the nerve fibers during the ablation process.

[0073] In one embodiment, Figure 2 As shown, step S130, determining the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress, includes steps S200 to S230.

[0074] Step S200, obtaining actual physiological parameters of the subject to which the target electrode acts, and corresponding target physiological parameters.

[0075] Step S210, determining the error amount of the physiological parameter during the ablation process according to the actual physiological parameter and the target physiological parameter.

[0076] Specifically, the actual physiological parameters are the physiological parameters actually collected from the target electrode's target object, which can be monitored in real time by monitoring instruments or measuring instruments, such as blood pressure, heart rate, etc. The target physiological parameters are the physiological parameters of the ideal target object expected during the ablation of the ablation area. That is, it can be considered that during the ablation of the ablation area, if the physiological parameters of the target object change in accordance with the target physiological parameters, the ablation effect is better. The target physiological parameters are ideal physiological parameters summarized through big data and accumulated experience. According to the deviation between the physiological parameters and the target physiological parameters, the error amount of the physiological parameters can be determined, which facilitates the subsequent adjustment of the power of the ablation energy corresponding to the ablation signal, so that the physiological parameters are close to the target physiological parameters at the corresponding moment.

[0077] Exemplarily, the changing trend of the target physiological parameter during the ablation progress can be roughly summarized as a slow rise in the physiological parameter at the beginning of ablation, and then turning into a downward trend after maintaining the rise for a period of time. Take the case where the physiological parameter is blood pressure as an example. The patient's blood pressure value is monitored in real time by an invasive blood pressure sensor. The invasive blood pressure sensor is a pressure sensor that can convert the pressure level into an electrical signal. After reading the patient's blood pressure, it is fed back to the host computer to draw a blood pressure change curve with time (unit s) as the horizontal axis and blood pressure (unit mmHg) as the vertical axis. Specifically, the invasive blood pressure sensor will convert the patient's real-time blood pressure into an electrical signal at a certain frequency (for example, 300Hz), and a series of blood pressure data fed back continuously can be obtained as follows. Figure 3 The original blood pressure fluctuations shown in the figure (expressed as a broken line that continuously fluctuates at a certain frequency, each fluctuation represents each cardiac cycle of the patient, the peak represents the systolic pressure, and the trough represents the diastolic pressure). After reading the original blood pressure fluctuations, the host computer will automatically identify the systolic and diastolic pressures in each cardiac cycle, that is, each point where the slope changes from positive to negative is marked as the systolic pressure (peak), and each point where the slope changes from negative to positive is marked as the diastolic pressure (trough), combined with certain conditional restrictions, such as the minimum spacing between two peaks and troughs, the minimum absolute value of the peak, and the maximum absolute value of the trough, so that the systolic and diastolic pressures can be automatically identified.

[0078] The identified systolic blood pressure can be used to calculate the blood pressure baseline and blood pressure fluctuation line. Specifically, the blood pressure baseline is equal to the average systolic blood pressure 10 seconds before ablation. Taking the time t=0s when the ablation starts as the dividing line, the blood pressure 10 seconds before ablation is displayed from t=-10s to the dividing line on the left side of the dividing line, and the blood pressure during the ablation process until the end of ablation is displayed on the right side of the dividing line. Therefore, the blood pressure baseline is equal to the average of all systolic blood pressures on the left side of the dividing line, and the blood pressure fluctuation line is calculated from all systolic blood pressures on the right side of the dividing line, which can be obtained by taking the average value or by fitting.

[0079] Step S220, respectively obtaining a first influencing factor of the physiological parameter on the target output power and a second influencing factor of the ablation input power on the target output power.

[0080] Among them, the size of the first influencing factor is negatively correlated with the ablation progress, so the influence of the physiological parameters on the target output power is negatively correlated with the ablation progress, and the size of the second influencing factor is positively correlated with the ablation progress, so the influence of the ablation input power on the target output power is positively correlated with the ablation progress.

[0081] Step S230, determining the target output power of the ablation energy corresponding to the ablation signal according to the error amount, the first influencing factor, the ablation input power, and the second influencing factor.

[0082] Specifically, according to the error amount and the first influencing factor, a first power can be obtained, that is, the first power obtained based on the physiological parameters, and according to the ablation input power and the second influencing factor, a second power can be obtained, that is, the second power obtained based on the ablation input power.

[0083] In this embodiment, a first power based on the physiological parameters is determined according to the error between the actual physiological parameters and the target physiological parameters combined with the first influencing factor, and a second power is determined according to the ablation input power combined with the second influencing factor. By combining the first power and the second power, the target output power of the ablation energy corresponding to the ablation signal can be obtained.

[0084] In one embodiment, Figure 4 As shown, step S230, determining the target output power of the ablation energy corresponding to the ablation signal according to the error amount, the first influencing factor, the ablation input power, and the second influencing factor, includes steps S400 to S420.

[0085] Step S400: determining a first power according to a product of an error amount and a first influencing factor.

[0086] Exemplarily, based on the deviation value between the physiological parameter and the target physiological parameter, a PID (proportion-integral-differential) controller can be used to calculate the power value corresponding to the error amount. The PID controller can also set the proportional coefficient, integral coefficient, differential coefficient and corresponding adjustment amount in the PID controller according to the size of the difference between the physiological parameter and the target physiological parameter, the rate of change, and the voltage limit range requirements.

[0087] The power corresponding to the error is determined by the following formula:

[0088]

[0089] Among them, u(t) is the power corresponding to the error, e(t) is the deviation between the physiological parameter and the target physiological parameter, K p is the proportionality coefficient, K i is the integration coefficient, K d is the differential coefficient.

[0090] The first power can be obtained by multiplying the power corresponding to the error amount by the first influence factor.

[0091] Step S410: determining the second power according to the product of the ablation input power and the second influencing factor.

[0092] Step S420: determining a target output power of the ablation energy corresponding to the ablation signal according to the sum of the first power and the second power.

[0093] Exemplarily, the target output power is determined according to the following formula:

[0094]

[0095] Where u(t) is the power corresponding to the error, P input is the ablation input power, is the first impact factor, is the second influencing factor, e is the natural index, t is the ablation time corresponding to the ablation progress, and a, b, and c are constants.

[0096] For example, during the ablation process, the target output power may vary with the ablation progress as follows: Figure 5As shown in the figure, in the early stage of ablation, the ablation power starts to rise from a low value. This is to increase the nerve tension in the ablation area through a certain degree of heat accumulation, activate endocrine changes and thus change physiological parameters. The ablation power increases with the change of physiological parameters. The speed and degree of increase of the ablation power are related to the change of physiological parameters. In this process, if unexpected fluctuations in physiological parameters occur, it means that there is no tissue that needs to be ablated in the current ablation area, or there is tissue that should not be ablated, then ablation can be stopped in time. If the changes in physiological parameters are as expected, then Figure 5 As shown in the figure, the ablation power will continue to rise until it converges to the vicinity of the ablation input power. The rising speed of the ablation power depends on the changing trend of the physiological parameters. For example, when the physiological parameter is blood pressure, if the blood pressure keeps rising, the corresponding power rising speed will also be adaptively maintained at a higher level, otherwise it will maintain a relatively gentle power rising speed. The final stable value of the ablation power is also related to the physiological parameters. The final ablation power will be adaptively maintained at a level slightly higher than the ablation input power, or slightly lower than the ablation input power. Taking blood pressure as an example, if the blood pressure continues to rise during the ablation process, it means that the location of the target nerve fiber is deep from the vascular wall, and effective ablation treatment is required. It is necessary to adaptively increase the power output level based on the ablation input power. In order to maintain safety during the ablation process at the same time, the actual output power will not exceed the upper limit output power. If the blood pressure has become flat during the ablation process, it means that the current power output level is sufficient to reach the location of the target nerve. It is meaningless to continue to increase the output power, but it will cause damage to deep non-target tissues. Therefore, in this case, the power output level will tend to be flat without reaching the ablation input power.

[0097] For example, the target output power determined based on the physiological parameters may also be discontinuous, that is, the determination is made only at the corresponding node based on the physiological parameters for a period of time. Figure 6 As shown, only at the nodes 30s and 60s after the start of ablation, the physiological parameters of 0-30s and 0-60s during the ablation process are analyzed to determine the target output power. Figure 7As shown, the target output power is determined only by analyzing the blood pressure response of 0-30s during the ablation process at the node 30s after the start of ablation. Since the analysis to determine the target output power is discontinuous, the analysis can only be started according to the established time node, and the time of each node and the time length of each stage cannot be adaptively adjusted according to the real-time blood pressure response, and the power control within the stage can only be achieved through an established function. However, the time of each node (can be any time point within 0-100s, generally 20, 30, 40 and 50, 60, 70 are preferred) and the function used for power control in each stage (can be a linear function, a quadratic function, a polynomial function, etc.) can be manually adjusted.

[0098] In this embodiment, the target output power of the ablation energy corresponding to the ablation signal is calculated according to the error amount, the first influencing factor, the ablation input power, and the second influencing factor, thereby realizing the calculation of the target output power.

[0099] In one embodiment, Figure 8 As shown, the ablation control method also includes steps S800 to S810.

[0100] Step S800, obtaining the changing trend of the physiological parameters during the ablation process.

[0101] Specifically, during the ablation process, physiological parameters are collected at preset time intervals, and the collected discrete physiological parameters are combined and plotted into a graph to obtain the changing trend of the physiological parameters.

[0102] Step S810, determining whether to stop providing the ablation signal to the target electrode according to the change trend of the physiological parameters, the target output power, and the ablation time corresponding to the current ablation progress.

[0103] Specifically, the changing trend of physiological parameters can reflect the state of the area to be ablated after the ablation energy is applied. The total amount of ablation energy currently applied to the area to be ablated can be determined according to the ablation time corresponding to the target output power and the current ablation progress. Therefore, based on the state of the area to be ablated and the total amount of ablation energy, it can be determined whether to stop providing the ablation signal to the target electrode.

[0104] In this embodiment, whether to stop providing the ablation signal to the target electrode is determined based on the changing trend of physiological parameters, the target output power, and the ablation time corresponding to the current ablation progress, so that the output of ablation energy can be stopped in time to avoid irreversible damage to the tissue in the area to be ablated.

[0105] In one embodiment, Fig. 9As shown, step S810 determines whether to stop providing the ablation signal to the target electrode according to the change trend of the physiological parameters, the target output power, and the ablation time corresponding to the current ablation progress, including steps S900-S920

[0106] Step S900: determining the total ablation energy cumulatively applied to the area to be ablated according to the target output power and the ablation duration.

[0107] Specifically, according to the target output power, multiplying it by the corresponding ablation time can obtain the total ablation energy cumulatively applied to the area to be ablated. For example, if the ablation power corresponding to 5W ablation energy is output for 5s, and then the ablation power corresponding to 10W ablation energy is output for 10s, the cumulative ablation energy is 5s*5W+10s*10W. Or, if the target output power is in the form of a function, the total ablation energy applied cumulatively can be determined based on the integral of the function curve over time.

[0108] Step S910: When the total ablation energy reaches a first threshold and the physiological parameter does not show an upward trend, stop providing the ablation signal to the target electrode.

[0109] Specifically, the first threshold is the energy value that can cause irreversible damage to the tissue in the ablation area. The lack of an upward trend in the physiological parameters indicates that there are no nerves that need to be ablated in the ablation area. When the total ablation energy reaches the first threshold, it means that the ablation energy is sufficient and there are no nerves that need to be ablated in the ablation area. However, since the ablation energy is not enough to cause changes in the physiological parameters, in this case, the physiological parameters still do not show an upward trend, and it is determined that there are no nerves that need to be ablated in the ablation area, so ablation is stopped.

[0110] Step S920: When the change trend of the physiological parameter conforms to the preset change trend and the total ablation energy reaches the second threshold, stop providing the ablation signal to the target electrode.

[0111] Specifically, the second threshold is an energy value that can ensure that it is sufficient to ablate the nerves that need to be ablated in the ablation area. When the total ablation energy reaches the second threshold, the nerves that need to be ablated in the ablation area must have been ablated. If the change trend of the physiological parameters conforms to the preset change trend, it means that there are nerves that need to be ablated in the ablation area, and the ablation location is correct. Therefore, when the ablation location is correct and the ablation energy is sufficient, the nerves that need to be ablated have been ablated, and the ablation is stopped.

[0112] Exemplarily, when the physiological parameter is blood pressure, when the blood pressure trend is first rising and then falling, and the total ablation energy reaches the second threshold, it is determined that the ablation is completed. This is because the heat-activated nerve fibers have been completely blocked and the blood pressure begins to drop.

[0113] In this embodiment, whether to stop ablation is determined based on the total ablation energy and the changing trends of the physiological parameters, so that ablation can be stopped in time when ablation is not needed, ensuring that no damage is caused to normal nerves.

[0114] In one embodiment, the ablation control method further includes: when the ablation duration corresponding to the current ablation progress reaches a set duration, stopping providing the ablation signal to the target electrode.

[0115] Specifically, because the target nerve to be ablated may be located too deep in the ablation area, the ablation energy released by the electrode cannot reach the target nerve. However, due to the effect of heat conduction, the target nerve will also be activated, causing physiological parameters such as blood pressure to remain high without a downward trend. It will be unanimously determined that there is a target nerve in the ablation area and ablation needs to continue. In this case, even if the ablation time is increased, the ablation effect is very limited. Increasing the ablation power may cause the shallow tissue to be vaporized and explode. Therefore, in this case, ablation needs to be terminated and other methods, such as treating tissues in nearby locations, blocking the deeper buried nerve fibers upstream and / or downstream of the nerve transmission pathway to clear the target nerve.

[0116] In this embodiment, when the ablation time is too long, the ablation needs to be terminated.

[0117] In one embodiment, Fig.10 As shown, step S140, adjusting the power of the ablation energy corresponding to the ablation signal according to the determined target output power, includes steps S1000 to S1010.

[0118] Step S1000: in the process of providing an ablation signal to a target electrode, obtaining the actual power of the ablation signal output by the target electrode.

[0119] Specifically, after the target output power is determined, an ablation signal with the target output power is provided to the target electrode. During this process, the actual power of the ablation signal actually output by the target electrode is collected. Due to signal transmission errors or other factors, the actual power may be inconsistent with the target output power.

[0120] Step S1010, feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual power and the target output power, so that the actual power reaches the target output power.

[0121] Specifically, first determine the difference between the actual power and the target output power, and then use a PI (proportion-integral) controller based on this difference. After the difference is subjected to geometric and integral operations, calculate the corrected power that will make the actual power reach the target output power, and then adjust the current actual power based on the determined corrected power. The geometric operation will amplify the difference and increase the speed of power adjustment, but the larger the amplification, the faster the adjustment, and it is also easy to adjust too much or too little, so that the actual power oscillates repeatedly above and below the target output power. The integral operation will accumulate and add the difference between the actual power and the target output power calculated each time, which is used to adjust errors with the same direction and a longer duration. The corrected power is obtained by combining the geometric operation result with the integral operation result. Using a PI controller, a faster adjustment speed can be achieved while the difference is amplified to a lesser extent to ensure that no oscillation occurs.

[0122] Exemplarily, the corrected power is determined by the following formula:

[0123] a(t)=K b b(t)+K a ∫0 t b(t)dt

[0124] Where a(t) is the corrected power, b(t) is the difference between the actual power and the target output power, and K b is the proportionality coefficient, K a is the integration coefficient.

[0125] In this embodiment, the power of the ablation energy corresponding to the ablation signal provided to the target electrode is feedback-regulated according to the difference between the actual power and the target output power, thereby ensuring the accuracy of the power control of the ablation energy corresponding to the ablation signal.

[0126] In one embodiment, Fig.11 As shown, the ablation control method also includes steps S1100 to S1110.

[0127] Step S1100, in the process of providing an ablation signal to a target electrode, obtaining the actual temperature of the area to be ablated.

[0128] Specifically, in addition to releasing ablation energy, the electrode can also collect the temperature of the area to be ablated and convert the temperature into electrical signals for transmission.

[0129] Step S1110: when the actual temperature is greater than the third threshold, stop providing the ablation signal to the target electrode.

[0130] Specifically, the actual temperature of the area to be ablated is monitored. When the actual temperature is greater than a third threshold, it means that the actual temperature of the area to be ablated is too high and it is dangerous to continue ablation, so the ablation signal is stopped from being provided to the target electrode.

[0131] In this embodiment, by monitoring the actual temperature of the area to be ablated, ablation can be stopped in time when the temperature is too high, thereby ensuring the safety of ablation.

[0132] In one embodiment, Fig.12 As shown, step S140, adjusting the power of the ablation energy corresponding to the ablation signal according to the determined target output power, includes steps S1200 to S1210.

[0133] Step S1200, in the process of providing an ablation signal to a target electrode, obtaining the actual temperature of the area to be ablated.

[0134] Specifically, the actual temperature of the area to be ablated may be acquired through the target electrode.

[0135] Step S1210, feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature, so that the actual temperature reaches the target temperature.

[0136] The target temperature corresponds to the target output power.

[0137] Specifically, after the target output power is determined, an ablation signal with the target output power is provided to the target electrode, and the temperature corresponding to the target output power is used as the target temperature. That is, after the ablation signal with the target output power is applied to the ablation area, its temperature should be the target temperature. However, in this process, the actual power of the ablation signal actually output by the target electrode is collected. Due to the error in signal transmission or other factors, the actual power may be inconsistent with the target output power, so there is a deviation between the actual temperature of the ablation area and the target temperature. According to this deviation, the corrected power is obtained after geometric and differential operations respectively. The current actual power is corrected using the corrected power, so that the actual temperature of the ablation area can reach the target temperature. The geometric operation will amplify the difference and increase the speed of power adjustment, while the differential operation will compare the actual temperature measured each time with the target temperature to calculate the temperature change rate. If the temperature rises, the differential operation result is a positive number, and if the temperature drops, the differential operation effect is a negative number. By subtracting the result of the differential operation from the result of the geometric operation, the rate of change of the differential operation can be controlled to avoid repeated oscillations or rapid changes in temperature when the amplification factor is large to ensure a faster response speed. Specifically, when the actual temperature rises too quickly, the differential operation result will be quickly amplified to correct the geometric operation under a high amplification factor so that the actual temperature does not exceed the target temperature, avoiding the situation where the actual temperature repeatedly oscillates around the target temperature.

[0138] Exemplarily, the corrected power is determined by the following formula:

[0139]

[0140] Where c(t) is the determined correction power, h(t) is the deviation between the actual temperature and the target temperature, K c is the proportionality coefficient, K d is the differential coefficient.

[0141] In this embodiment, the power of the ablation energy corresponding to the ablation signal provided to the target electrode is feedback-regulated according to the difference between the actual temperature and the target temperature, thereby ensuring the accuracy of the power control of the ablation energy corresponding to the ablation signal.

[0142] In one embodiment, the ablation control method also includes: in the process of feedback adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature, when the target output power is greater than the power limit, if the power of the ablation energy corresponding to the adjusted ablation signal is greater than the power limit, then the power of the ablation energy corresponding to the ablation signal provided to the target electrode is set to the power limit.

[0143] Specifically, during the ablation process, if the target output power is greater than the power limit, then during the process of adjusting the actual power, the power of the ablation energy corresponding to the adjusted ablation signal will be greater than the power limit. To ensure safety, even if the actual temperature cannot reach the target temperature, the power of the ablation energy corresponding to the ablation signal provided to the target electrode can only be set to the power limit.

[0144] In this embodiment, by setting the power limit, it is ensured that the power of the ablation energy corresponding to the ablation signal will not be too high, thereby ensuring the safety of ablation.

[0145] In one embodiment, Fig.13 As shown, a complete flowchart of an ablation process is provided, and the ablation process includes steps S1300 to S1430.

[0146] Step S1300, obtaining target blood pressure, actual blood pressure, and ablation input power.

[0147] Step S1310, substituting the difference between the target blood pressure and the actual blood pressure into the PID controller to obtain the first power.

[0148] Step S1320: ablate input power according to the first power to obtain target output power.

[0149] Step S1330: adjusting the power of the ablation energy corresponding to the ablation signal according to the determined target output power.

[0150] Step S1340, when the target output power is greater than the power limit, if the power of the ablation energy corresponding to the adjusted ablation signal is greater than the power limit, the power of the ablation energy corresponding to the ablation signal provided to the target electrode is set to the power limit.

[0151] Step S1350, obtaining the actual power of the ablation signal output by the target electrode.

[0152] Step S1360: feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual power and the target output power.

[0153] Step S1370, obtaining the actual temperature of the area to be ablated.

[0154] Step S1380, feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature.

[0155] Step S1390, determining whether the total ablation energy reaches the first threshold value and the physiological parameters do not show an upward trend. If the total ablation energy reaches the first threshold value and the physiological parameters do not show an upward trend, step S1430 is executed to stop providing the ablation signal to the target electrode; if the total ablation energy does not reach the first threshold value or the physiological parameters do not show an upward trend, step S1400 is executed.

[0156] Step S1400, determining whether the change trend of the physiological parameter conforms to the preset change trend, and the total ablation energy reaches the second threshold. If the change trend of the physiological parameter conforms to the preset change trend, and the total ablation energy reaches the second threshold, step S1430 is executed; if the change trend of the physiological parameter does not conform to the preset change trend, or the total ablation energy reaches the second threshold, step S1410 is executed.

[0157] Step S1410, determining whether the ablation duration corresponding to the current ablation progress reaches the set duration. If the ablation duration corresponding to the current ablation progress reaches the set duration, executing step S1430, if the ablation duration corresponding to the current ablation progress does not reach the set duration, executing step S1420.

[0158] Step S1420, determining whether the actual temperature is greater than a third threshold value. If the actual temperature is greater than the third threshold value, executing step S1430, if the actual temperature is less than or equal to the third threshold value, returning to executing step S1300.

[0159] Step S1430, stop providing the ablation signal to the target electrode.

[0160] In this embodiment, a complete process of an ablation process is provided, and its contents have been described in the above embodiments and will not be repeated here.

[0161] It should be understood that although Figure 1 , 2 The steps in the flowcharts of , 4, 8-13 are shown in sequence as indicated by the arrows, but these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified in this document, there is no strict order restriction for the execution of these steps, and these steps can be executed in other orders. Moreover, Figure 1 , 2 , 4, and at least part of the steps in 8-13 may include multiple steps or multiple stages. These steps or stages do not necessarily have to be performed at the same time, but can be performed at different times. The execution order of these steps or stages does not necessarily have to be performed sequentially, but can be performed in rotation or alternation with other steps or at least part of the steps or stages in other steps.

[0162] In one embodiment, Fig.14As shown, an ablation control system is provided, comprising: an electrode assembly, an ablation module 20, a detection module 30, and a control module 40, wherein:

[0163] The electrode assembly includes a catheter 12 and at least one electrode 11 disposed on the catheter 12 at intervals.

[0164] Specifically, the catheter 12 is used to carry the electrode 11 and enter the body of the target object, so as to deliver the electrode 11 to the position where ablation is required. For example, the catheter 12 enters the body through puncture of a single femoral artery, so that the electrode 11 can transmit radiofrequency ablation energy to the renal artery intima. The electrode 11 is a component that can release energy and can release ablation energy to achieve the ablation effect.

[0165] The ablation module 20 is connected to at least one electrode 11 and is used to provide an ablation signal to the target electrode 11 , wherein the target electrode 11 is one of the at least one electrode 11 .

[0166] Specifically, the ablation module 20 can output an ablation signal, which can be a high-power ablation energy in watts. The high-power ablation energy refers to energy that can cause destructive damage to cells in a specific part and cause them to die when acting on the specific part. Exemplarily, the output power of the ablation energy can be 0-40W, which is adjusted as needed.

[0167] The detection module 30 is used to obtain physiological parameters of the subject to which the target electrode 11 acts.

[0168] Specifically, the detection module 30 can be an invasive blood pressure sensor or a heart rate meter, etc. The physiological parameters of the subject can be collected in a conventional manner. The puncture sheath connected to the invasive blood pressure sensor and the puncture sheath tube of the catheter 12 entering the human body enter from the left and right femoral arteries respectively to avoid the movement of the catheter 12 during the operation of the catheter 12 affecting the blood pressure reading.

[0169] The control module 40 is connected to the ablation module 20 and the detection module 30 respectively, and is used to obtain the ablation input power corresponding to the area to be ablated, control the ablation module 20 to provide an ablation signal to the target electrode 11, so as to control the target electrode 11 to apply ablation energy to the area to be ablated, and obtain physiological parameters in the process of providing the ablation signal to the target electrode 11, and determine the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress. According to the determined target output power, the ablation module 20 is controlled to adjust the power of the ablation energy corresponding to the ablation signal provided to the target electrode 11.

[0170] Among them, the initial power of the ablation signal is less than the ablation input power, the influence of the physiological parameters on the target output power is negatively correlated with the ablation progress, and the influence of the ablation input power on the target output power is positively correlated with the ablation progress. That is, the influence of the physiological parameters on the target output power decreases with the progress of the ablation, and the influence of the ablation input power on the target output power increases with the progress of the ablation.

[0171] In this embodiment, by setting the electrode assembly, ablation energy can be applied to the area to be ablated. By setting the ablation module 20, an ablation signal can be provided to the electrode 11, and by setting the detection module 30, the physiological parameters of the object of action can be obtained. By setting the control module 40, the ablation input power corresponding to the area to be ablated is first obtained, that is, the reference rated power required to ablate the area to be ablated is obtained. The ablation input power can be directly input by the doctor, and then the ablation signal is provided to the target electrode 11, so that the ablation energy is applied to the area to be ablated through the target electrode 11, and the ablation and removal of the area to be ablated can be achieved, and the initial power of the ablation signal is less than the ablation input power, that is, the power of the ablation energy corresponding to the ablation signal at the beginning is very small, and the effect of ablation and removal cannot be achieved, but the damage to the area to be ablated is also very small, which is to facilitate the subsequent gradual adjustment of the power of the ablation energy corresponding to the ablation signal according to the physiological parameters, so as to avoid the ablation energy corresponding to the ablation signal at the beginning. The power is too large and causes irreversible damage to the object of action. Then, in the process of applying ablation energy to the area to be ablated, the physiological parameters are obtained. Then, according to the physiological parameters, ablation input power and ablation progress, the target output power of the ablation energy corresponding to the ablation signal is comprehensively determined. In the process of determining the target output power, the influence of the physiological parameters on the target output power is negatively correlated with the ablation progress, and the influence of the ablation input power on the target output power is positively correlated with the ablation progress. Therefore, in the early stage of applying ablation energy to the area to be ablated, the target output power of the ablation energy corresponding to the ablation signal is mainly determined by the physiological parameters, which enables the target output power of the ablation energy corresponding to the ablation signal to be adjusted according to the physiological parameters, so as to correspond to the current state of the area to be ablated, that is, the target output power is matched with the patient's real-time physiological parameters, so that the power of the ablation energy corresponding to the ablation signal can just achieve the effect of ablation and removal, and can avoid irreversible damage to the nerves in the area to be ablated due to excessive power. As the ablation progresses, the target output power will converge toward the ablation input power input by the doctor, and finally converge to the vicinity of the ablation input power to ensure the ablation effect. In summary, the method of the present application can adaptively adjust the power of the ablation energy corresponding to the ablation signal according to the patient's physiological parameters during the ablation process, and ablate the sympathetic nerves in the ablation area while avoiding irreversible damage to the nerve fibers during the ablation process.

[0172] In one embodiment, Fig.15 As shown, the ablation control system further includes: a temperature sensor 50 and a collection module 60, wherein:

[0173] The temperature sensor 50 is disposed on the catheter 12 and is used to collect the temperature of the area to be ablated.

[0174] The acquisition module 60 is connected to the temperature sensor 50 and the control module 40 respectively, and is used to acquire the temperature of the area to be ablated and transmit it to the control module 40 .

[0175] The control module 40 is also used to control the ablation module 20 to stop providing the ablation signal to the target electrode 11 when the temperature of the area to be ablated is greater than a set temperature.

[0176] In this embodiment, by setting up a temperature sensor 50, the temperature of the area to be ablated is monitored. When the temperature of the area to be ablated is greater than the set temperature, the control module 40 can control the ablation module 20 to stop providing the ablation signal to the target electrode 11, thereby ensuring the safety of the area to be ablated.

[0177] In one embodiment, Fig.16 As shown, an ablation control device is provided, including: a power acquisition module 1601, an output module 1602, a parameter acquisition module 1603, a power determination module 1604, and an adjustment module 1605, wherein:

[0178] The power acquisition module 1601 is used to acquire the ablation input power corresponding to the area to be ablated.

[0179] The output module 1602 is used to provide an ablation signal to the target electrode to control the target electrode to apply ablation energy to the area to be ablated, wherein the initial power of the ablation signal is less than the ablation input power.

[0180] The parameter acquisition module 1603 is used to acquire physiological parameters during the process of applying ablation energy to the area to be ablated, wherein the physiological parameters are physiological parameters of the object of action of the target electrode.

[0181] The power determination module 1604 is used to determine the target output power of the ablation energy corresponding to the ablation signal based on physiological parameters, ablation input power and ablation progress, wherein the influence of the physiological parameters on the target output power decreases as the ablation progresses, and the influence of the ablation input power on the target output power increases as the ablation progresses.

[0182] The adjustment module 1605 is used to adjust the power of the ablation energy corresponding to the ablation signal according to the determined target output power.

[0183] In one embodiment, the power determination module 1604 further includes: an error determination unit, a parameter determination unit, and a power determination unit, wherein:

[0184] The error determination unit is used to determine the error amount of the physiological parameter during the ablation process according to the physiological parameter and the target physiological parameter.

[0185] The parameter determination unit is used to respectively obtain a first influencing factor of the physiological parameter on the target output power and a second influencing factor of the ablation input power on the target output power, wherein the first influencing factor is negatively correlated with the ablation progress, and the second influencing factor is positively correlated with the ablation progress.

[0186] The power determination unit is used to determine the target output power of the ablation energy corresponding to the ablation signal according to the error amount, the first influencing factor, the ablation input power, and the second influencing factor.

[0187] In one embodiment, the power determination unit includes: a first calculation subunit, a second calculation subunit, and a third calculation subunit, wherein:

[0188] The first calculation subunit is used to determine the first power according to the product of the error amount and the first influencing factor.

[0189] The second calculation subunit is used to determine the second power according to the product of the ablation input power and the second influencing factor.

[0190] The third calculation subunit is used to determine the target output power of the ablation energy corresponding to the ablation signal according to the sum of the first power and the second power.

[0191] In one embodiment, the ablation control device further includes: a trend acquisition unit and a stop determination unit, wherein:

[0192] The trend acquisition unit is used to obtain the changing trend of the physiological parameters during the ablation process.

[0193] The stop judgment unit is used to determine whether to stop providing the ablation signal to the target electrode according to the change trend of the physiological parameters, the target output power, and the ablation time corresponding to the current ablation progress.

[0194] In one embodiment, the stop determination unit includes: an energy determination subunit, a first stop subunit, and a second stop subunit, wherein:

[0195] The energy determination subunit is used to determine the total ablation energy cumulatively applied to the area to be ablated according to the target output power and the ablation duration.

[0196] The first stop subunit is used to stop providing the ablation signal to the target electrode when the total ablation energy reaches a first threshold and the physiological parameter does not show an upward trend.

[0197] The second stop subunit is used to stop providing the ablation signal to the target electrode when the change trend of the physiological parameter conforms to the preset change trend and the total ablation energy reaches a second threshold.

[0198] In one embodiment, the ablation control device further includes: a stop module. The stop module is used to stop providing the ablation signal to the target electrode when the ablation time corresponding to the current ablation progress reaches a set time.

[0199] In one embodiment, the regulating module 1605 includes: a power acquisition unit and a first regulating unit, wherein:

[0200] The power acquisition unit is used to acquire the actual power of the ablation signal output by the target electrode during the process of providing the ablation signal to the target electrode.

[0201] The first regulating unit is used to feedback regulate the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual power and the target output power, so that the actual power reaches the target output power.

[0202] In one embodiment, the adjustment module 1605 includes: a temperature acquisition unit and a second adjustment unit, wherein:

[0203] The temperature acquisition unit is used to acquire the actual temperature of the area to be ablated during the process of providing the ablation signal to the target electrode.

[0204] The second regulating unit is used to feedback regulate the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature, so that the actual temperature reaches the target temperature, wherein the target temperature corresponds to the target output power.

[0205] In one embodiment, the ablation control device further includes: a temperature acquisition module and a stop output module, wherein:

[0206] The temperature acquisition module is used to acquire the actual temperature of the area to be ablated during the process of providing the ablation signal to the target electrode.

[0207] The stop output module is used to stop providing the ablation signal to the target electrode when the actual temperature is greater than the third threshold value.

[0208] In one embodiment, the ablation control device further includes: a limiting module. The limiting module is used for, in the process of feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature, in the case where the target output power is greater than the power limit, if the power of the ablation energy corresponding to the adjusted ablation signal is greater than the power limit, setting the power of the ablation energy corresponding to the ablation signal provided to the target electrode to the power limit.

[0209] For the specific definition of the ablation control device, please refer to the definition of the ablation control method above, which will not be repeated here. The various modules in the above-mentioned ablation control device can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in or independent of the processor in the computer device in the form of hardware, or can be stored in the memory of the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules. It should be noted that the division of modules in the embodiment of the present application is schematic and is only a logical function division. There may be other division methods in actual implementation.

[0210] In one embodiment, a computer device is provided, wherein the internal structure diagram of the computer device can be as follows: Fig.17 As shown. The computer device includes a processor, a memory and a network interface connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The network interface of the computer device is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, an ablation control method is implemented.

[0211] Those skilled in the art will understand that Fig.17 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0212] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the steps in the above-mentioned method embodiments when executing the computer program.

[0213] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented.

[0214] In one embodiment, a computer program product is provided, including a computer program, which implements the steps in the above method embodiments when executed by a processor.

[0215] Those of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory may include read-only memory (ROM), magnetic tape, floppy disk, flash memory or optical memory, etc. Volatile memory may include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0216] In the description of this specification, the description with reference to the terms "some embodiments", "other embodiments", "ideal embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example.

[0217] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0218] The above-mentioned embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. An ablation control method, characterized in that: include: Obtaining ablation input power corresponding to the area to be ablated; Providing an ablation signal to a target electrode to control the target electrode to apply ablation energy to the area to be ablated, wherein the initial power of the ablation energy is less than the ablation input power; In the process of applying ablation energy to the area to be ablated, a physiological parameter is acquired, wherein the physiological parameter is a physiological parameter of an object acted upon by the target electrode; Determine the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress, wherein the influence of the physiological parameters on the target output power decreases as the ablation progresses, and the influence of the ablation input power on the target output power increases as the ablation progresses; The power of the ablation energy corresponding to the ablation signal is adjusted according to the determined target output power.

2. The ablation control method according to claim 1, characterized in that: Determining the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameter, the ablation input power and the ablation progress includes: Acquiring actual physiological parameters of the target electrode's target subject and corresponding target physiological parameters; Determining an error amount of the physiological parameter during the ablation process according to the actual physiological parameter and the target physiological parameter; Respectively obtain a first influencing factor of the physiological parameter on the target output power and a second influencing factor of the ablation input power on the target output power; wherein the magnitude of the first influencing factor is negatively correlated with the ablation progress, and the magnitude of the second influencing factor is positively correlated with the ablation progress; A target output power of the ablation energy corresponding to the ablation signal is determined according to the error amount, the first influencing factor, the ablation input power, and the second influencing factor.

3. The ablation control method according to claim 2, characterized in that: The step of determining a target output power of the ablation energy corresponding to the ablation signal according to the error amount, the first influencing factor, the ablation input power, and the second influencing factor includes: Determine a first power according to a product of the error amount and the first influencing factor; Determining a second power according to the product of the ablation input power and a second influencing factor; The target output power of the ablation energy corresponding to the ablation signal is determined according to the sum of the first power and the second power.

4. The ablation control method according to claim 1, characterized in that: The method further comprises: Obtaining the changing trend of the physiological parameters during the ablation process; Whether to stop providing the ablation signal to the target electrode is determined according to the change trend of the physiological parameter, the target output power, and the ablation duration corresponding to the current ablation progress.

5. The ablation control method according to claim 4, characterized in that: The determining whether to stop providing the ablation signal to the target electrode according to the change trend of the physiological parameter, the target output power, and the ablation duration corresponding to the current ablation progress includes: Determining the total ablation energy cumulatively applied to the area to be ablated according to the target output power and the ablation duration; When the total ablation energy reaches a first threshold and the physiological parameter does not show an upward trend, stop providing the ablation signal to the target electrode; And / or, when the change trend of the physiological parameter conforms to the preset change trend and the total ablation energy reaches a second threshold, stop providing the ablation signal to the target electrode.

6. The ablation control method according to claim 1, characterized in that: The method further comprises: When the ablation time corresponding to the current ablation progress reaches the set time, the ablation signal is stopped from being provided to the target electrode.

7. The ablation control method according to claim 1, characterized in that: The step of adjusting the power of the ablation signal according to the determined target output power comprises: In the process of providing the ablation signal to the target electrode, obtaining the actual power of the ablation energy corresponding to the ablation signal output by the target electrode; According to the difference between the actual power and the target output power, the power of the ablation energy corresponding to the ablation signal provided to the target electrode is feedback-regulated so that the actual power reaches the target output power.

8. The ablation control method according to claim 1, characterized in that: The method further comprises: In the process of providing the ablation signal to the target electrode, obtaining the actual temperature of the area to be ablated; When the actual temperature is greater than a third threshold, supplying the ablation signal to the target electrode is stopped.

9. The ablation control method according to claim 1, characterized in that: The step of adjusting the power of the ablation signal according to the determined target output power comprises: In the process of providing the ablation signal to the target electrode, obtaining the actual temperature of the area to be ablated; According to the difference between the actual temperature and the target temperature, the power of the ablation energy corresponding to the ablation signal provided to the target electrode is feedback-regulated so that the actual temperature reaches the target temperature, wherein the target temperature corresponds to the target output power.

10. The ablation control method according to claim 9, characterized in that: The method further comprises: In the process of feedback-adjusting the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the difference between the actual temperature and the target temperature, when the target output power is greater than the power limit, if the power of the ablation energy corresponding to the adjusted ablation signal is greater than the power limit, the power of the ablation energy corresponding to the ablation signal provided to the target electrode is set to the power limit.

11. An ablation control system, characterized in that: include: An electrode assembly, comprising a catheter and at least one electrode spaced apart on the catheter; an ablation module, connected to the at least one electrode, for providing an ablation signal to a target electrode, wherein the target electrode is one of the at least one electrode; A detection module, used for obtaining physiological parameters of an object acted upon by the target electrode; A control module is respectively connected to the ablation module and the detection module, and is used to obtain the ablation input power corresponding to the area to be ablated, control the ablation module to provide an ablation signal to the target electrode, so as to control the target electrode to apply ablation energy to the area to be ablated, and in the process of providing the ablation signal to the target electrode, obtain the physiological parameters, and determine the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress; and control the ablation module to adjust the power of the ablation energy corresponding to the ablation signal provided to the target electrode according to the determined target output power, wherein the initial power of the ablation energy is less than the ablation input power, the degree of influence of the physiological parameters on the target output power decreases as the ablation progresses, and the degree of influence of the ablation input power on the target output power increases as the ablation progresses.

12. The ablation control system according to claim 11, characterized in that: The ablation control system further includes: A temperature sensor, arranged on the catheter, for collecting the temperature of the area to be ablated; an acquisition module, connected to the temperature sensor and the control module respectively, for acquiring the temperature of the area to be ablated and transmitting the temperature to the control module; The control module is further configured to control the ablation module to stop providing the ablation signal to the target electrode when the temperature of the area to be ablated is greater than a set temperature.

13. An ablation control device, characterized in that: include: A power acquisition module, used to acquire the ablation input power corresponding to the area to be ablated; an output module, configured to provide an ablation signal to a target electrode, so as to control the target electrode to apply ablation energy to the area to be ablated, wherein the initial power of the ablation energy is less than the ablation input power; A parameter acquisition module, used for acquiring physiological parameters in the process of applying ablation energy to the area to be ablated, wherein the physiological parameters are physiological parameters of the object of action of the target electrode; A power determination module, used to determine the target output power of the ablation energy corresponding to the ablation signal according to the physiological parameters, the ablation input power and the ablation progress, wherein the influence of the physiological parameters on the target output power decreases as the ablation progresses, and the influence of the ablation input power on the target output power increases as the ablation progresses; The regulating module is used to regulate the power of the ablation energy corresponding to the ablation signal according to the determined target output power.

14. A computer device comprising a memory and a processor, wherein the memory stores a computer program, wherein: When the processor executes the computer program, the steps of the method according to any one of claims 1 to 10 are implemented.

15. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 10 are implemented.

16. A computer program product comprising a computer program, characterized in that When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 10 are implemented.

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