Moisturizing mask containing carrageenan and preparation method thereof

Abstract

The invention discloses a moisture mask containing carrageenan and a preparation method thereof, and belongs to the technical field of carrageenan application and mask preparation. Kappa-carrageenan, iota-carrageenan and konjac glucomannan are compounded for use, the stability is better, and then the kappa-carrageenan, iota-carrageenan and konjac glucomannan are compounded with acryloyl modified cyclodextrin and carrageenan polysaccharide, so that the moisturizing effect can be exerted, a more compact network structure is formed after crosslinking, the stability of a system structure is further improved, the hydrogen-bond interaction is increased, and the stability of the system structure is improved. The water binding force in the system is enhanced, the loss of functional components is reduced, and the water bleeding problem of the coating type moisturizing mask is reduced. In addition, the components interact with each other, and the functional components are loaded on the composite colloid and can be better absorbed and utilized when being attached to the skin, so that the purpose of better coordinating and conditioning the skin is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of carrageenan application and facial mask preparation, and in particular to a moisturizing facial mask containing carrageenan and a preparation method thereof. Background Art

[0002] Carrageenan is a natural polysaccharide whose skeleton is formed by alternating D-galactose with α-(1-3) or β-(1-4) linkages. It can be classified according to the presence of 3,6-anhydro-D-galactose at the 1-4 linkage and the position and content of its sulfate group. According to the connection form of its sugar units and the number of sulfate groups, it is divided into κ-carrageenan, ι-carrageenan and λ-carrageenan. Among them, κ-carrageenan is composed of galactose and 3,6-anhydrogalactose containing 4-sulfate ester groups connected by alternating 1,3-α- and 1,4-β-glycosidic bonds, and each disaccharide repeating unit carries a negative charge. ι-carrageenan carries two negative charges. κ-carrageenan and ι-carrageenan have similar properties. Under certain temperature conditions, both will undergo thermally reversible conformational arrangements and have excellent gelling properties. The molecular chain of λ-carrageenan is relatively stable, and the structure maintains a random coil conformation, so λ-carrageenan needs the action of trivalent iron ions to gel. As a hydrophilic colloid, carrageenan has excellent film-forming and gelling properties and can be added to the preparation of facial masks as a film-forming agent and thickener. However, single κ-carrageenan is relatively brittle and single ι-carrageenan has poor spreadability. Therefore, the gelling properties of single κ-carrageenan and single ι-carrageenan cannot reach the performance of facial masks. For example, Chinese patent application number CN201310081530.9 discloses a sheet-like facial mask and its manufacturing process, which uses carrageenan and gellan gum as film-forming agents. Although the performance of the facial mask is improved to a certain extent, the function is single and the loading and moisturizing effects of carrageenan cannot be fully exerted.

[0003] In the prior art, konjac gum is added to skin care products as a thickening and film-forming component. Konjac gum is a fixed molar ratio of β-D-glucose and β-D-mannose connected by β-1,4-mannanose bonds. However, due to the large number of hydroxyl groups in its polymer chain, it has the disadvantage of obvious water precipitation.

[0004] In addition, as people's quality of life improves, they take care of their skin in more ways. From raw materials to functions, the facial masks developed in the market are becoming more and more diverse. The facial masks in the prior art also have poor water-locking and moisturizing performance, which is not conducive to the skin's absorption of effective ingredients. For example, the Chinese patent publication number CN108030702 discloses a water-locking and moisturizing facial mask cloth and its preparation method and application, in which a hydrophobic organic polymer is sprayed onto a surface of a non-woven fabric, and a hydrophobic layer is prepared on the surface of a hydrophilic non-woven fabric, so that the prepared non-woven fabric has a unidirectional water-conducting and water-locking and moisturizing function. However, due to the large gaps between the fibers in the microstructure of the non-woven surface, part of the water in the nutrient solution of the inner layer of the non-woven fabric will still pass through the gaps between the hydrophobic fibers, resulting in a decrease in the water-locking performance of the moisturizing mask; in addition, the hydrophobic polymer on the fiber surface has a weak adhesion to the fiber and is easily detached from the fiber surface, resulting in a further decrease in the water-locking performance of the mask. Therefore, there is a need in the prior art to develop a safe facial mask that has excellent water-locking and moisturizing abilities and multiple functions. Summary of the invention

[0005] Based on this, in order to solve the technical problems that the existing facial mask has poor stability, cannot load the effective ingredients better, and has unsatisfactory effect, the present invention provides a moisturizing facial mask containing carrageenan and a preparation method thereof. The specific technical scheme is as follows:

[0006] A moisturizing facial mask containing carrageenan, the moisturizing facial mask comprising the following preparation raw materials in parts by weight:

[0007] 5 to 15 parts of kappa-carrageenan, 7 to 10 parts of iota-carrageenan, 5 to 8 parts of konjac gum, 1 to 7 parts of acryloyl-modified cyclodextrin, 1 to 3 parts of carrageenan, 7 to 13 parts of sodium hyaluronate, 3 to 7 parts of moisturizer, 1 to 15 parts of composite plant extract, 1 to 5 parts of antioxidant, 1 to 2 parts of glycerin, 1 to 2 parts of penetration enhancer, 1 to 2 parts of emulsifier, and 15 to 50 parts of deionized water;

[0008] The composite plant extract is obtained by mixing chamomile extract, perilla leaf extract, sophora flavescens extract and licorice extract in a mass ratio of (1-3): (1-7): (1-2): (5-7).

[0009] Furthermore, the strength of the κ-carrageenan is 1300 g / cm 2 ~1500g / cm 2 The strength of the iota-carrageenan is 300 g / cm 2 ~1000g / cm 2 .

[0010] Furthermore, the preparation method of the κ-carrageenan is as follows: adding Eucheuma auris to a sodium hydroxide solution with a mass percentage concentration of 5% to 10%, heating to 75°C to 80°C for alkali treatment for 20min to 60min, washing, and then adding to a sodium chloride solution with a mass percentage concentration of 0.1% to 0.5%, extracting for 30min to 60min at 80°C to 90°C and an ultrasonic frequency of 25KHz to 50KHz, filtering, and then purifying the obtained glue solution, and drying to obtain κ-carrageenan.

[0011] Furthermore, the preparation method of iota-carrageenan is as follows: adding Eucheuma spinulosa to a sodium hydroxide solution with a mass percentage concentration of 5% to 10%, adding it to 60°C to 80°C for alkali treatment for 20min to 60min, washing it, and then adding it to a sodium chloride solution with a mass percentage concentration of 0.1% to 0.5%, extracting it at 70°C to 90°C and an ultrasonic frequency of 20KHz to 25KHz for 30min to 60min, filtering it, purifying the obtained glue solution, and drying it to obtain iota-carrageenan.

[0012] Furthermore, the antioxidant is at least one of tea polyphenols, apple tannins, butylated hydroxyanisole and ascorbic acid.

[0013] Furthermore, the penetration enhancer is 1,2-pentanediol.

[0014] Furthermore, the moisturizing agent is at least one of butylene glycol, polyethylene glycol-400, maltol, squalene and methylpropanediol.

[0015] Furthermore, the emulsifier is hydrogenated lecithin.

[0016] In addition, the present invention also provides a method for preparing a moisturizing facial mask containing carrageenan, the preparation method comprising the following steps:

[0017] κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water are mixed, heated to 45° C. to 65° C., stirred at a speed of 100 r / min to 150 r / min for 30 min to 60 min, and then allowed to stand for 1 h to 3 h to obtain a mixture A;

[0018] Sodium hyaluronate, moisturizer, composite plant extract, glycerin, penetration enhancer, emulsifier and the remaining 1 / 2 of deionized water are mixed, treated with a high-speed disperser at a speed of 10000 r / min to 12000 r / min for 1 min to 3 min, and then a high-pressure homogenizer is used to perform high-pressure microfluidization homogenization and emulsification several times at a pressure of 100 MPa to 120 MPa to obtain a mixture B;

[0019] The mixture B and the antioxidant are sequentially added to the mixture A, and the mixture is fully stirred at 65° C. to 85° C. for 30 min to 60 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

[0020] Furthermore, the particle size of the mixture B is 20nm to 200nm.

[0021] Compared with the prior art, this application has the following beneficial effects:

[0022] 1. The present invention uses a compound of kappa-carrageenan, iota-carrageenan and konjac gum, which has better stability. The compound is further compounded with acryl-modified cyclodextrin and carrageenan, which can not only exert its own moisturizing effect, but also form a denser network structure after cross-linking, further increase the stability of the system structure, and increase the hydrogen bonding effect, so that the water binding force in the system is enhanced, the water locking ability is increased, the component distribution is more uniform, and it is also helpful to improve the mechanical strength and the load capacity of the gel, reduce the loss of effective ingredients, and reduce the water analysis problem of the film-type moisturizing mask.

[0023] 2. The facial mask prepared by the present invention has excellent biocompatibility and skin fit, high uniformity and stability of ingredients, and the effective ingredients are loaded on the composite colloid, which can be better absorbed and utilized when attached to the skin, achieving the purpose of better synergistic skin conditioning. Among them, chamomile extract can reduce inflammation and calm the skin; perilla leaf extract can promote skin water balance and skin repair, and has anti-inflammatory and antibacterial effects; sophora flavescens extract can help resist free radicals and synergistically moisturize; licorice extract can soothe the skin and inhibit the formation of melanin. The synergistic effect of several ingredients can help improve the anti-oxidation, anti-bacterial and anti-inflammatory effects of the facial mask and promote skin repair while ensuring excellent moisturizing effects.

[0024] 3. This application optimizes the ingredients and ingredient ratios to obtain a mask with a moisturizing effect as a whole. The effective ingredients, under the action of the penetration enhancer, can achieve the effect of conditioning the skin as a whole. Nano-emulsification will also be carried out in the process to further promote the skin's absorption of the effective ingredients. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with its embodiments. It should be understood that the specific implementation methods described herein are only used to explain the present invention and do not limit the scope of protection of the present invention.

[0026] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0027] A moisturizing facial mask containing carrageenan in one embodiment of the present invention comprises the following raw materials in parts by weight:

[0028] 5 to 15 parts of kappa-carrageenan, 7 to 10 parts of iota-carrageenan, 5 to 8 parts of konjac gum, 1 to 7 parts of acryloyl-modified cyclodextrin, 1 to 3 parts of carrageenan, 7 to 13 parts of sodium hyaluronate, 3 to 7 parts of moisturizer, 1 to 15 parts of composite plant extract, 1 to 5 parts of antioxidant, 1 to 2 parts of glycerin, 1 to 2 parts of penetration enhancer, 1 to 2 parts of emulsifier, and 15 to 50 parts of deionized water;

[0029] The composite plant extract is obtained by mixing chamomile extract, perilla leaf extract, sophora flavescens extract and licorice extract in a mass ratio of (1-3): (1-7): (1-2): (5-7).

[0030] In one embodiment, the strength of the κ-carrageenan is 1300 g / cm 2 ~1500g / cm 2 The strength of the iota-carrageenan is 300 g / cm 2 ~1000g / cm 2 .

[0031] In one embodiment, the purity of the κ-carrageenan is ≥ 99.9%, and the purity of the ι-carrageenan is ≥ 99.9%.

[0032] In one of the embodiments, the preparation method of κ-carrageenan is as follows: adding Eucheuma auris to a sodium hydroxide solution with a mass percentage concentration of 5% to 10%, heating to 75°C to 80°C for alkali treatment for 20min to 60min, washing, and then adding to a sodium chloride solution with a mass percentage concentration of 0.1% to 0.5%, extracting for 30min to 60min at 80°C to 90°C and an ultrasonic frequency of 25KHz to 50KHz, filtering, and then purifying the obtained glue solution, and drying to obtain κ-carrageenan.

[0033] In one of the embodiments, the preparation method of iota-carrageenan is as follows: adding Eucheuma spinulosa to a sodium hydroxide solution with a mass percentage concentration of 5% to 10%, adding it to 60°C to 80°C for alkali treatment for 20min to 60min, washing it, and then adding it to a sodium chloride solution with a mass percentage concentration of 0.1% to 0.5%, extracting it at 70°C to 90°C and an ultrasonic frequency of 20KHz to 25KHz for 30min to 60min, filtering it, purifying the obtained glue solution, and drying it to obtain iota-carrageenan.

[0034] In one embodiment, the molecular weight of the konjac gum is 137.8-621.5 Kda.

[0035] In one embodiment, the purity of the konjac gum is ≥99.9%.

[0036] In one embodiment, the antioxidant is at least one of tea polyphenols, apple tannins, butylated hydroxyanisole and ascorbic acid.

[0037] In one embodiment, the penetration enhancer is 1,2-pentanediol.

[0038] In one embodiment, the moisturizing agent is at least one of butylene glycol, polyethylene glycol-400, maltol, squalene and methylpropanediol.

[0039] In one embodiment, the emulsifier is hydrogenated lecithin.

[0040] In addition, the present invention also provides a method for preparing a moisturizing facial mask containing carrageenan, the preparation method comprising the following steps:

[0041] κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water are mixed, heated to 45° C. to 65° C., stirred at a speed of 100 r / min to 150 r / min for 30 min to 60 min, and then allowed to stand for 1 h to 3 h to obtain a mixture A;

[0042] Sodium hyaluronate, moisturizer, composite plant extract, glycerin, penetration enhancer, emulsifier and the remaining 1 / 2 of deionized water are mixed, treated with a high-speed disperser at a speed of 10000 r / min to 12000 r / min for 1 min to 3 min, and then a high-pressure homogenizer is used to perform high-pressure microfluidization homogenization and emulsification several times at a pressure of 100 MPa to 120 MPa to obtain a mixture B;

[0043] The mixture B and the antioxidant are sequentially added to the mixture A, and the mixture is fully stirred at 65° C. to 85° C. for 30 min to 60 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

[0044] In one embodiment, the particle size of the mixture B is 20nm-200nm.

[0045] The moisturizing mask in the above scheme can improve the overall stability of the system by optimizing the ingredients and ingredient ratios and combining the process, give full play to the effects of the active ingredients, and achieve significant moisturizing, antibacterial and anti-inflammatory, and skin conditioning effects.

[0046] The embodiments of the present invention will be described in detail below with reference to specific examples.

[0047] Embodiment 1:

[0048] A moisturizing facial mask containing carrageenan comprises the following raw materials in parts by weight:

[0049] 10 parts of κ-carrageenan, 7 parts of ι-carrageenan, 5 parts of konjac gum, 7 parts of acryloyl-modified cyclodextrin, 2 parts of carrageenan, 10 parts of sodium hyaluronate, 4 parts of maltol, 10 parts of composite plant extract, 3 parts of tea polyphenols, 2 parts of glycerol, 2 parts of 1,2-pentanediol, 2 parts of hydrogenated lecithin, and 36 parts of deionized water; wherein the composite plant extract is obtained by mixing chamomile extract, perilla leaf extract, sophora flavescens extract and licorice extract in a mass ratio of 3:5:2:5.

[0050] A method for preparing a moisturizing facial mask containing carrageenan comprises the following steps:

[0051] The Eucheuma auriculata was added to a sodium hydroxide solution with a mass percentage concentration of 8%, heated to 75° C. for alkali treatment for 60 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.5%, extracted at 80° C. and an ultrasonic frequency of 25 KHz for 55 minutes, filtered, and then the obtained gelatin solution was purified and dried to obtain κ-carrageenan;

[0052] The Eucheuma spinulosa was added to a sodium hydroxide solution with a mass percentage concentration of 10%, added to 80° C. for alkali treatment for 50 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.3%, extracted for 60 minutes at 75° C. and an ultrasonic frequency of 20 KHz, filtered, and the obtained glue solution was purified and dried to obtain ι-carrageenan;

[0053] κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water were mixed, heated to 60° C., stirred at a speed of 100 r / min for 45 min, and then allowed to stand for 2 h to obtain a mixture A;

[0054] Sodium hyaluronate, maltol, compound plant extract, glycerin, 1,2-pentanediol, hydrogenated lecithin and the remaining 1 / 2 of deionized water were mixed, treated with a high-speed disperser at a speed of 10000 r / min for 2 min, and then homogenized and emulsified by high-pressure microfluidization with a high-pressure homogenizer at a pressure of 100 MPa for 5 times to obtain a mixture B;

[0055] The mixture B and tea polyphenols were sequentially added to the mixture A, fully stirred at 70° C. for 40 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

[0056] Embodiment 2:

[0057] A moisturizing facial mask containing carrageenan comprises the following raw materials in parts by weight:

[0058] 7 parts of kappa-carrageenan, 10 parts of iota-carrageenan, 6 parts of konjac gum, 6 parts of acryloyl-modified cyclodextrin, 3 parts of carrageenan, 9 parts of sodium hyaluronate, 3 parts of polyethylene glycol-400, 10 parts of composite plant extract, 5 parts of apple tannins, 1 part of glycerol, 1 part of 1,2-pentanediol, 2 parts of hydrogenated lecithin, and 37 parts of deionized water; wherein the composite plant extract is obtained by mixing chamomile extract, perilla leaf extract, sophora flavescens extract and licorice extract in a mass ratio of 2:6:1:6.

[0059] A method for preparing a moisturizing facial mask containing carrageenan comprises the following steps:

[0060] The Eucheuma auriculata was added to a sodium hydroxide solution with a mass percentage concentration of 8%, heated to 80° C. for alkali treatment for 60 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.3%, extracted for 60 minutes at 85° C. and an ultrasonic frequency of 25 KHz, filtered, and then the obtained glue solution was purified and dried to obtain κ-carrageenan;

[0061] The Eucheuma spinulosa was added to a sodium hydroxide solution with a mass percentage concentration of 10%, added to 80° C. for alkali treatment for 60 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.4%, extracted for 55 minutes at 80° C. and an ultrasonic frequency of 25 KHz, filtered, and the obtained glue solution was purified and dried to obtain ι-carrageenan;

[0062] κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water were mixed, heated to 65° C., stirred at a speed of 120 r / min for 50 min, and then allowed to stand for 2 h to obtain a mixture A;

[0063] Sodium hyaluronate, polyethylene glycol-400, compound plant extract, glycerin, 1,2-pentanediol, hydrogenated lecithin and the remaining 1 / 2 of deionized water were mixed, treated with a high-speed disperser at a speed of 12000 r / min for 2 min, and then homogenized and emulsified by high-pressure microfluidization for 6 times at a pressure of 100 MPa using a high-pressure homogenizer to obtain a mixture B;

[0064] The mixture B and apple tannin were added to the mixture A in sequence, and the mixture was fully stirred at 75° C. for 55 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

[0065] Embodiment 3:

[0066] A moisturizing facial mask containing carrageenan comprises the following raw materials in parts by weight:

[0067] 12 parts of κ-carrageenan, 7 parts of ι-carrageenan, 8 parts of konjac gum, 2 parts of acryloyl-modified cyclodextrin, 1 part of carrageenan, 12 parts of sodium hyaluronate, 3 parts of butylene glycol, 15 parts of composite plant extract, 1 part of ascorbic acid, 1 part of glycerol, 1 part of 1,2-pentanediol, 2 parts of hydrogenated lecithin, and 35 parts of deionized water; wherein the composite plant extract is obtained by mixing chamomile extract, perilla leaf extract, sophora flavescens extract and licorice extract in a mass ratio of 1:6:1:7.

[0068] A method for preparing a moisturizing facial mask containing carrageenan comprises the following steps:

[0069] The Eucheuma auriculata was added to a sodium hydroxide solution with a mass percentage concentration of 10%, heated to 80° C. for alkali treatment for 60 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.3%, extracted at 90° C. and an ultrasonic frequency of 25 KHz for 50 minutes, filtered, and then the obtained gelatin solution was purified and dried to obtain κ-carrageenan;

[0070] The Eucheuma spinulosa was added to a sodium hydroxide solution with a mass percentage concentration of 10%, added to 75° C. for alkali treatment for 55 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.4%, extracted for 60 minutes at 85° C. and an ultrasonic frequency of 25 KHz, filtered, and the obtained glue solution was purified and dried to obtain ι-carrageenan;

[0071] κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water were mixed, heated to 65° C., stirred at a speed of 150 r / min for 60 min, and then allowed to stand for 2 h to obtain a mixture A;

[0072] Sodium hyaluronate, butylene glycol, composite plant extract, glycerin, 1,2-pentanediol, hydrogenated lecithin and the remaining 1 / 2 of deionized water were mixed, treated with a high-speed disperser at a speed of 12000 r / min for 3 minutes, and then homogenized and emulsified by high-pressure microfluidization with a high-pressure homogenizer at a pressure of 120 MPa for 5 times to obtain a mixture B;

[0073] The mixture B and ascorbic acid were sequentially added to the mixture A, fully stirred at 80° C. for 60 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

[0074] Comparative Example 1:

[0075] The difference between Comparative Example 1 and Example 3 is that in Comparative Example 1, 30 parts of commercially available ordinary carrageenan are used instead (12 parts of κ-carrageenan, 7 parts of ι-carrageenan, 8 parts of konjac gum, 2 parts of acryloyl-modified cyclodextrin, and 1 part of carrageenan), and the rest is the same as Example 3.

[0076] Comparative Example 2:

[0077] The difference between Comparative Example 2 and Example 3 is that 30 parts of konjac gum are used instead (12 parts of κ-carrageenan, 7 parts of ι-carrageenan, 8 parts of konjac gum, 2 parts of acryloyl-modified cyclodextrin, and 1 part of carrageenan) in Comparative Example 2, and the rest is the same as Example 3.

[0078] Comparative Example 3:

[0079] The difference between Comparative Example 3 and Example 3 is that no acryl-modified cyclodextrin is added in Comparative Example 3, and the rest is the same as Example 3.

[0080] Comparative Example 4:

[0081] The difference between Comparative Example 4 and Example 3 is that no composite plant extract is added in Comparative Example 4, and the rest is the same as Example 3.

[0082] Comparative Example 5:

[0083] The difference between Comparative Example 5 and Example 3 is that the composite plant extract in Comparative Example 5 is obtained by mixing chamomile extract, perilla leaf extract and sophora flavescens extract in a mass ratio of 7:1:7, and the rest is the same as Example 3.

[0084] Comparative Example 6:

[0085] The difference between Comparative Example 6 and Example 3 is that the composite plant extract in Comparative Example 6 (obtained by mixing chamomile extract, sophora flavescens extract and licorice extract in a mass ratio of 7:2:6) is the same as Example 3 in other aspects.

[0086] Comparative Example 7:

[0087] The difference between Comparative Example 7 and Example 3 is that the composite plant extract in Comparative Example 7 (obtained by mixing chamomile extract and Sophora flavescens extract in a mass ratio of 7:8) is used, and the rest is the same as Example 3.

[0088] Comparative Example 8:

[0089] The difference between Comparative Example 8 and Example 3 is that the composite plant extract in Comparative Example 8 is obtained by mixing chamomile extract and licorice extract in a mass ratio of 8:7, and the rest is the same as Example 3.

[0090] Comparative Example 9:

[0091] The difference between Comparative Example 9 and Example 3 is that 1,2-pentanediol is not added in Comparative Example 9, and the rest is the same as Example 3.

[0092] Comparative Example 10:

[0093] The difference between Comparative Example 10 and Example 3 is that the preparation method in Comparative Example 10 is different, and the rest is the same as Example 3. Specifically, the preparation method of Comparative Example 10 includes the following steps:

[0094] The Eucheuma auriculata was added to a sodium hydroxide solution with a mass percentage concentration of 10%, heated to 80° C. for alkali treatment for 60 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.3%, extracted at 90° C. and an ultrasonic frequency of 25 KHz for 50 minutes, filtered, and then the obtained gelatin solution was purified and dried to obtain κ-carrageenan;

[0095] The Eucheuma spinulosa was added to a sodium hydroxide solution with a mass percentage concentration of 10%, added to 75° C. for alkali treatment for 55 minutes, washed, and then added to a sodium chloride solution with a mass percentage concentration of 0.4%, extracted for 60 minutes at 85° C. and an ultrasonic frequency of 25 KHz, filtered, and the obtained glue solution was purified and dried to obtain ι-carrageenan;

[0096] κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water were mixed, heated to 65° C., stirred at a speed of 150 r / min for 60 min, and then allowed to stand for 2 h to obtain a mixture A;

[0097] Mix sodium hyaluronate, butylene glycol, compound plant extract, glycerin, 1,2-pentanediol, hydrogenated lecithin and the remaining 1 / 2 of deionized water to obtain a mixture B;

[0098] The mixture B and ascorbic acid were sequentially added to the mixture A, fully stirred at 80° C. for 60 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

[0099] 1. Stability test: a. High temperature performance test, the samples of Examples 1 to 3 and the comparative samples of Comparative Examples 1 to 10 (70 g) were placed in a 60°C oven for heating for 8 hours, the time was recorded, and the stability of the mask performance was observed. b. Low temperature test, the samples of Examples 1 to 3 and the comparative samples of Comparative Examples 1 to 10 (70 g) were placed in a -20°C refrigerator for freezing for 24 hours, taken out of the refrigerator, thawed to room temperature (4 hours), and weighed to see whether water precipitated from the samples or comparative samples. The results are shown in Table 1 below.

[0100] Table 1: Stability

[0101]

[0102]

[0103] From the data analysis of Table 1, it can be seen that in the present application, carrageenan is compounded with κ-carrageenan, ι-carrageenan, konjac gum, and acryloyl-modified cyclodextrin to form a network structure, the overall structure is more stable, and it can be used as a smearable facial mask, which greatly improves the usability of the facial mask.

[0104] 2. In order to verify the safety of the formulation of this application, the following cytotoxicity test was performed.

[0105] The moisturizing mask sample prepared in Example 3 was used as a test product, and the sample was evaluated using the L929 cell model and CCK8 evaluation method. L929 cells were inoculated in a 96-well plate at a number of 8,000 per well, and then the well plate was placed in an incubator at 37°C, 5% CO2 and saturated humidity for 24 hours. After 24 hours, the well plate was taken out, the old culture medium in the well was discarded, and 100 μL DMEM culture medium was added to the corresponding well, and the culture medium contained the samples of Example 3 with gradient mass concentrations of (0.1%, 1% and 5%), and 6 groups of parallels were set for each concentration. At the same time, a blank control (DMEM culture medium without any active ingredients) and 1% zinc diethyldithiocarbamate (ZDEC) were set as positive controls, and the reagent was added and continued to be incubated for 24 hours. After 24 hours, the well plate was taken out, each well was washed once with 100 μL PBS, and after discarding, 100 μL of a solution containing 10% CCK8 prepared with serum-free DMEM culture medium was added to each well. Then the well plate was returned to the incubator and incubated for another 50 minutes. After the incubation, the absorbance was measured using an ELISA instrument, and the results showed that the cell viability at all concentrations exceeded 100%, indicating that the ingredients of the moisturizing mask of the present application were non-cytotoxic and had high overall safety.

[0106] 3. Skin moisture content test: The samples of the moisturizing masks of Examples 1 to 3 of the present application and the comparative samples of the moisturizing masks obtained in Comparative Examples 1 to 10 were tested. 130 testers were randomly selected and divided into 13 groups (Examples 1 to 3 and Comparative Examples 1 to 10), with 10 people in each group. The skin moisture content was tested using the skin quality diagnosis expert MC760 skin tester of the German CK company. The samples of the above embodiments and the comparative samples in the comparative examples were applied to the inner forearm skin of the test subjects (about 8 square centimeters) and kept for 20 minutes before peeling off. The skin moisture content was measured 0 minutes before use and 20 minutes, 40 minutes and 60 minutes after use. The change in moisture content is reflected in the test period, and the moisture content of the experimental area changes with time. The larger the value, the greater the moisture content, and vice versa, the smaller the moisture content. Hydration rate = (moisture content at each time point after use-initial moisture content) / initial moisture content, and the test results are shown in Table 2.

[0107] Table 2: Skin moisture content

[0108]

[0109] From the data analysis of Table 1, it can be seen that the ingredients of the moisturizing mask containing carrageenan provided in the present application work synergistically with each other and have a significant moisturizing effect. The difference between Comparative Examples 1 to 9 and Example 3 is that the ingredients in Comparative Examples 1 to 9 are different, but it can be clearly seen that the ingredients of the present application have a positive effect on promoting the skin to absorb moisture, and the process in Comparative Example 10 is different. After comparative analysis, it can also be seen that the ingredients after nanoemulsification are more easily absorbed by the skin, thereby ensuring the moisture of the skin.

[0110] 4. Skin conditioning auxiliary effect test

[0111] In order to evaluate the repairing effect of the moisturizing mask of the present invention, the samples of Examples 1 to 3 and the comparative samples of Comparative Examples 1 to 10 were tested on volunteers. 130 participants, aged between 25 and 30, were randomly divided into 13 groups, 10 in each group, and the subjects had different degrees of redness, swelling, acne, red blood streaks and other symptoms on their facial skin; one cycle (3 consecutive days, after cleaning the face, apply the corresponding test product, pause for 2 days), record once, and then continue to apply the corresponding test product for 3 consecutive cycles, and record the effect once in each cycle. During the experiment, the subjects did not apply any other skin care products. The results are shown in Table 3 below.

[0112] The evaluation criteria are as follows:

[0113] Cured: Symptoms such as sensitive and inflamed skin, redness, swelling, acne, and red blood streaks have basically disappeared, and the skin lesion area has improved by ≥85%.

[0114] Significantly effective: Signs of sensitive and inflammatory skin, redness, swelling, acne, and red blood streaks were significantly improved, and the skin lesion area improved by ≥65%.

[0115] Effective: Sensitive and inflammatory skin, redness, swelling, acne, red blood streaks, etc. are significantly improved, and the skin lesion area is improved by ≥45%.

[0116] Ineffective: Sensitive and inflamed skin, redness, swelling, acne, red blood streaks, etc. did not improve, and even showed a trend of getting worse.

[0117] Table 3: Skin conditioning effects

[0118]

[0119]

[0120] From the test results analysis of Table 3, it can be seen that the facial mask of the present application, under the compounding effect of κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin and carrageenan polysaccharide, can provide a more excellent moisturizing effect while ensuring its stability, and can load active ingredients to achieve a better skin conditioning effect. In addition, the composite plant extract of the present application, the optimized ingredients and ingredient ratio, under the promoting penetration of 1,2-pentanediol and the nano-emulsification of the process, synergistically, can repair the skin as a whole, calm and reduce inflammation, and exert a more significant skin conditioning effect.

[0121] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0122] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A moisturizing facial mask containing carrageenan, characterized in that: The moisturizing facial mask comprises the following raw materials in parts by weight: 5 to 15 parts of kappa-carrageenan, 7 to 10 parts of iota-carrageenan, 5 to 8 parts of konjac gum, 1 to 7 parts of acryloyl-modified cyclodextrin, 1 to 3 parts of carrageenan, 7 to 13 parts of sodium hyaluronate, 3 to 7 parts of moisturizer, 1 to 15 parts of composite plant extract, 1 to 5 parts of antioxidant, 1 to 2 parts of glycerin, 1 to 2 parts of penetration enhancer, 1 to 2 parts of emulsifier, and 15 to 50 parts of deionized water; The composite plant extract is obtained by mixing chamomile extract, perilla leaf extract, sophora flavescens extract and licorice extract in a mass ratio of (1-3): (1-7): (1-2): (5-7).

2. The moisturizing facial mask according to claim 1, characterized in that: The strength of the κ-carrageenan is 1300 g / cm 2 ~1500g / cm 2 The strength of the iota-carrageenan is 300 g / cm 2 ~1000g / cm 2 .

3. The moisturizing facial mask according to claim 2, characterized in that: The preparation method of the κ-carrageenan comprises the following steps: adding Eucheuma auriculata to a sodium hydroxide solution with a mass percentage concentration of 5% to 10%, heating to 75° C. to 80° C. for alkali treatment for 20 min to 60 min, washing, then adding to a sodium chloride solution with a mass percentage concentration of 0.1% to 0.5%, extracting for 30 min to 60 min at 80° C. to 90° C. and an ultrasonic frequency of 25 KHz to 50 KHz, filtering, purifying the obtained gelatin solution, and drying to obtain the κ-carrageenan.

4. The moisturizing facial mask according to claim 2, characterized in that: The preparation method of iota-carrageenan comprises the following steps: adding Eucheuma spinulosa to a sodium hydroxide solution with a mass percentage concentration of 5% to 10%, adding the solution to 60° C. to 80° C. for alkali treatment for 20 min to 60 min, washing the solution, then adding the solution to a sodium chloride solution with a mass percentage concentration of 0.1% to 0.5%, extracting the solution at 70° C. to 90° C. and an ultrasonic frequency of 20 KHz to 25 KHz for 30 min to 60 min, filtering the solution, purifying the solution, and drying the solution to obtain iota-carrageenan.

5. The moisturizing facial mask according to claim 1, characterized in that: The antioxidant is at least one of tea polyphenols, apple tannins, butylated hydroxyanisole and ascorbic acid.

6. The moisturizing facial mask according to claim 1, characterized in that: The penetration enhancer is 1,2-pentanediol.

7. The moisturizing facial mask according to claim 1, characterized in that: The moisturizing agent is at least one of butylene glycol, polyethylene glycol-400, maltol, squalene and methylpropanediol.

8. The moisturizing facial mask according to claim 1, characterized in that: The emulsifier is hydrogenated lecithin.

9. A method for preparing a moisturizing facial mask containing carrageenan, characterized in that: The preparation method is used to prepare the moisturizing facial mask according to any one of claims 1 to 8, and the preparation method comprises the following steps: κ-carrageenan, ι-carrageenan, konjac gum, acryloyl-modified cyclodextrin, carrageenan and 1 / 2 deionized water are mixed, heated to 45° C. to 65° C., stirred at a speed of 100 r / min to 150 r / min for 30 min to 60 min, and then allowed to stand for 1 h to 3 h to obtain a mixture A; Sodium hyaluronate, moisturizer, composite plant extract, glycerin, penetration enhancer, emulsifier and the remaining 1 / 2 of deionized water are mixed, treated with a high-speed disperser at a speed of 10000 r / min to 12000 r / min for 1 min to 3 min, and then a high-pressure homogenizer is used to perform high-pressure microfluidization homogenization and emulsification several times at a pressure of 100 MPa to 120 MPa to obtain a mixture B; The mixture B and the antioxidant are sequentially added to the mixture A, and the mixture is fully stirred at 65° C. to 85° C. for 30 min to 60 min, and allowed to stand and cool to room temperature to obtain a moisturizing facial mask.

10. The preparation method according to claim 9, characterized in that: The particle size of the mixture B is 20 nm to 200 nm.

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