Anti-allergic paste and its preparation method and application

Abstract

The present invention provides an anti-allergic paste and its preparation method and application, belonging to the technical field of pharmaceutical ointments, the anti-allergic paste includes a carrier and a paste body; the carrier includes the following components by mass percentage: 41-44% of oil and fat, 21-23% of hydrogel, 13-14% of fatty alcohol, 4-5% of emulsifier, 12-13% of thermosensitive hydroxypropyl methylcellulose and water balance; the paste body includes the following components by weight: 5-7 parts of Nanchuan Mubo Luo, 4-5 parts of Scutellaria baicalensis, 2-3 parts of Phellodendron chinense, 0.3-0.5 parts of honeysuckle-gardenia-purslane steam extract, 2-3 parts of Forsythia suspensa, 0.7-0.9 parts of Sophora flavescens, 0.5-0.8 parts of Dictamnus cortex, 0.5-0.8 parts of Kochia scoparia and 5-6 parts of Artemisia argyi oil. The present invention improves the therapeutic effect while reducing side effects.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical ointments, and particularly relates to an anti-allergic ointment and a preparation method and application thereof. Background Art

[0002] Localized skin allergies refer to allergic reactions to certain substances, typically manifesting as localized redness, itching, swelling, and rashes. There are many causes, including contact allergens, cosmetics, detergents, and metals; food allergies, such as seafood, milk, and eggs; drug allergies, such as antibiotics and nonsteroidal anti-inflammatory drugs; and environmental factors, such as climate change and ultraviolet rays. Common treatments include: avoiding contact with allergens, which involves identifying the cause of the allergy and avoiding it as much as possible; applying cold compresses, which involves applying ice packs or wet towels to the affected area to help relieve itching and swelling; moisturizing, which involves using mild moisturizing creams or lotions to keep the skin moisturized to help relieve symptoms; and medication, which involves using antihistamines, such as antihistamines (loratadine, chlorpheniramine, etc.) or topical steroid ointments (hydrocortisone cream, dexamethasone acetate ointment, etc.).

[0003] The above-mentioned commonly used anti-allergic drugs are all Western medicines, mainly used to treat allergic reactions, such as local skin allergy symptoms. Although antihistamines (loratadine, chlorpheniramine, etc.) can relieve allergic symptoms such as redness, itching and swelling, these drugs are generally divided into three generations, each with its own specific side effects. Hormone ointments (hydrocortisone cream and dexamethasone acetate ointment) contain hormone ingredients. Although they can quickly relieve inflammation and allergic reactions, long-term use or large-area use may cause side effects such as thinning of the skin and pigmentation, and rebound phenomenon is prone to occur after discontinuation of the drug, that is, the symptoms worsen. Summary of the Invention

[0004] In order to solve the problems existing in the background technology, the present invention provides an anti-allergic paste and a preparation method and application thereof, which can improve the efficacy while reducing side effects.

[0005] In order to achieve the above-mentioned objectives, in a first aspect, the present invention provides an anti-allergic paste, comprising a carrier and a paste body;

[0006] The carrier comprises the following components by mass percentage: 41-44% oil, 21-23% hydrogel, 13-14% fatty alcohol, 4-5% emulsifier, 12-13% heat-sensitive hydroxypropyl methylcellulose and the balance water;

[0007] The paste comprises the following components by weight: 5-7 parts of Artocarpus nanchuanensis, 4-5 parts of Scutellaria baicalensis, 2-3 parts of Phellodendron amurense, 0.3-0.5 parts of honeysuckle-gardenia jasminoides-purslane steam extract, 2-3 parts of Forsythia suspensa, 0.7-0.9 parts of Sophora flavescens, 0.5-0.8 parts of Dictamnus cortex, 0.5-0.8 parts of Kochia scoparia fruit and 5-6 parts of Artemisia argyi oil.

[0008] Furthermore, the preparation method of the heat-sensitive hydroxypropyl methylcellulose is as follows:

[0009] A1. Mix equal amounts of a 7-9% hydroxypropyl methylcellulose aqueous solution and a 7-9% poly (N-isopropylacrylamide) aqueous solution to obtain a mixed solution.

[0010] A2. Treat the mixture obtained in A1 in a fume hood at 60-70°C until a viscous gel-like substance forms;

[0011] A3. Transfer the gel-like substance obtained in A2 to an oven, dry it at 85-90°C for 3-5 hours, take it out, grind it into powder, and obtain heat-sensitive hydroxypropyl methylcellulose.

[0012] Furthermore, the oil comprises one or a mixture of at least two of white vaseline, liquid paraffin, and lanolin.

[0013] Furthermore, the hydrogel is carbomer.

[0014] Furthermore, the fatty alcohol includes stearyl alcohol or cetyl alcohol.

[0015] Furthermore, the emulsifier includes polysorbate or Span.

[0016] Furthermore, the preparation method of the honeysuckle-gardenia-purslane steam extract is as follows:

[0017] A1. Weigh honeysuckle, gardenia, and purslane in a mass ratio of 1:(1-1.2):(1.3-1.5), mix to obtain a raw material, add 3-4 times the weight of the raw materials in 65-70°C water, and soak for 1-2 hours to obtain an infusion.

[0018] A2. Add 7-8 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 10-12 hours to obtain a liquid;

[0019] A3. Concentrate the liquid obtained in A2 to 3-3.5 times the total weight of the raw materials, let it stand for 8-12 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane water vapor extract.

[0020] In a second aspect, the present invention provides a method for preparing the above-mentioned anti-allergic paste, comprising the following steps:

[0021] S1. Prepare a carrier;

[0022] Heat and melt the oil, mix the hydrogel with water, add fatty alcohol after mixing, add emulsifier while continuing to stir, add heat-sensitive hydroxypropyl methylcellulose, transfer to a high-speed homogenizer for homogenization, and naturally cool to room temperature to obtain the carrier;

[0023] S2, preparing the paste body;

[0024] Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark, and Kochia scoparia fruit are ground to obtain a mixed fine material; the mixed fine material is evenly mixed with honeysuckle-gardenia jasminoides-purslane steam extract, and mugwort oil is added, and the mixture is continuously stirred to obtain a paste.

[0025] Furthermore, in S1, the speed of the high-speed homogenizer is 5000-6000 r / min, the temperature is 28-30° C., and the processing time is 1-1.5 h.

[0026] In a third aspect, the present invention provides an application of the above-mentioned anti-allergic cream, wherein the carrier is first applied to the affected area of the skin and its surrounding area, and then pressed clockwise for 3-5 minutes to form a carrier layer, and then the cream body is applied on the carrier layer.

[0027] This application has the following beneficial effects:

[0028] 1. The anti-allergic paste of the present invention includes a carrier and a paste body. The paste body is a pure herbal (traditional Chinese medicine) ingredient, has no side effects, and has good anti-allergic / antipruritic effects. The carrier can assist in the sustained release of the effective therapeutic ingredients of the paste body, ensuring long-lasting and reliable therapeutic effects, thereby improving the anti-allergic / antipruritic effects. Moreover, experiments have verified that the addition of heat-sensitive hydroxypropyl methylcellulose in the preparation of the carrier of the present invention and the addition of honeysuckle-gardenia-purslane water vapor extract in the preparation of the paste body of the present invention have a synergistic effect, which can synergistically improve the anti-allergic / antipruritic effects of the anti-allergic paste of the present invention.

[0029] 2. In the preparation of the carrier of the present invention, oil can form a protective film on the skin surface, which helps to slowly release the drug ingredients in the paste body; hydrogel can absorb and retain moisture, thereby helping to gradually release the drug ingredients; fatty alcohol can form a stable oil-water mixture, maintaining the sustained-release balance of different drug ingredients; emulsifiers are beneficial to the mutual dissolution of oil and water on the one hand, and on the other hand, can help the drug ingredients form a stable state between oil and water, thereby prolonging the stable residence time of the drug on the skin; thermosensitive hydroxypropyl methylcellulose is more sensitive to the body temperature of mice / humans. After being applied to the skin surface, it is beneficial to more accurately screen the relevant drug ingredients and control their sustained-release speed and effect, which is beneficial to improve the efficacy of the drug and reduce side effects.

[0030] 3. In the preparation of thermosensitive hydroxypropyl methylcellulose, hydroxypropyl methylcellulose is a water-soluble polymer, and poly (N-isopropylacrylamide) is a temperature-sensitive polymer, which has unique temperature responsiveness in a moisture environment. When the temperature is higher than its lower critical solution temperature (about 32°C), it will undergo a phase transition from hydrophilic to hydrophobic. This also makes the thermosensitive hydroxypropyl methylcellulose prepared in the present invention have this thermosensitive ability, so that when the thermosensitive hydroxypropyl methylcellulose of the present invention is applied to the skin of mice / humans, it undergoes a phase change due to body temperature, thereby more accurately screening and controlling the sustained release rate and effect of the honeysuckle-gardenia-purslane water vapor extract, so as to synergistically improve the anti-allergic / antipruritic effect of the anti-allergic cream of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 , a comparative trend chart of the anti-allergic / antipruritic effect test data of the products obtained from Examples 1-7 of the present invention and Comparative Examples 1-7. DETAILED DESCRIPTION

[0032] The present application is further described in detail below with reference to the embodiments.

[0033] Unless otherwise specified, the raw materials used in the examples and comparative examples of the present application are all commercially available.

[0034] Example 1: (1) Preparation of heat-sensitive hydroxypropyl methylcellulose, the preparation method is as follows:

[0035] A1. Mix equal amounts of 8% hydroxypropyl methylcellulose aqueous solution and poly (N-isopropylacrylamide) aqueous solution, stirring at 250 rpm for 20 minutes to achieve a uniform mixing effect, to obtain a mixed solution.

[0036] A2. The mixture obtained in A1 was stirred at 200 r / min in a fume hood at 68°C to allow the water to evaporate slowly until a viscous gel-like substance was formed. The entire process took 11.5 hours.

[0037] A3. Transfer the gel-like substance obtained in A2 to an oven, dry it at 86°C for 4 hours, take it out, grind it into powder, and obtain heat-sensitive hydroxypropyl methylcellulose.

[0038] (2) Prepare the carrier, and the preparation method is as follows:

[0039] Calculate the components by mass percentage: 42% of oil, 22% of hydrogel, 13.5% of fatty alcohol, 4.5% of emulsifier, 12.5% of heat-sensitive hydroxypropyl methylcellulose and 5.5% of water.

[0040] Heat and melt the oil, mix the hydrogel with water, and then add the fatty alcohol. While stirring continuously at 280 r / min, add the emulsifier and then heat-sensitive hydroxypropyl methylcellulose. Continue stirring at 280 r / min for 20 minutes, then transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5500 r / min, the temperature is 30°C, and the processing time is 1.2 hours. Then, remove the mixture and place it in a container and cool it naturally to room temperature to obtain the carrier.

[0041] The oil is white petrolatum, the hydrogel is carbomer, the fatty alcohol is stearyl alcohol, and the emulsifier is polysorbate.

[0042] White petrolatum (petroleum grease-petrolatum, 70% oil content) was purchased from Shanghai Yuejiang Titanium Dioxide Chemical Products Co., Ltd. Carbomer (model 676, content ≥99%, brand Lubrizol, USA) was purchased from Guangzhou Gongying Chemical Co., Ltd. Stearyl alcohol, specifically 1618 alcohol (cetearyl alcohol), was purchased from Guangzhou Bolu Chemical Co., Ltd. Polysorbate (Tween 80, premium grade) was purchased from Hai'an Petrochemical Plant in Jiangsu Province.

[0043] (3) Preparation of honeysuckle-gardenia-purslane steam extract, the preparation method is as follows:

[0044] A1. Weigh honeysuckle, gardenia, and purslane in a mass ratio of 1:1:1, mix to obtain a raw material, add 68°C water (3 times their weight), and soak for 1.5 hours to obtain an infusion.

[0045] A2. Add 7 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 11 hours to obtain a liquid.

[0046] A3. Concentrate the liquid obtained in A2 to 3 times the total weight of the raw materials, let it stand for 10 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane water vapor extract.

[0047] (4) Prepare the paste body, the preparation method is as follows:

[0048] The components were weighed in parts by weight: 6 parts of Artocarpus nanchuanensis, 4.5 parts of Scutellaria baicalensis, 2.5 parts of Phellodendron amurense, 0.4 parts of honeysuckle-gardenia jasminoides-purslane steam extract, 2.5 parts of Forsythia suspensa, 0.8 parts of Sophora flavescens, 0.7 parts of Dictamnus cortex, 0.6 parts of Kochia scoparia and 5.5 parts of Artemisia argyi oil.

[0049] Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark, and Kochia scoparia fruit are ground to obtain a mixed fine material; the mixed fine material is mixed with the honeysuckle-gardenia jasminoides-purslane steam extract, and stirred at a stirring speed of 200 r / min for 30 minutes until the mixture is uniformly mixed, and then mugwort oil is added and stirred at a stirring speed of 300 r / min for 30 minutes to mix uniformly to obtain the paste body.

[0050] Among them, Artocarpus nanchuanensis is fresh meat without core and roasted until the moisture content reaches about 10%. Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamnus chinensis bark and Kochia scoparia fruit are all commercially available dried medicinal materials.

[0051] (5) Application of anti-allergic cream: Specific steps: First, apply the carrier evenly to the affected area and surrounding areas. The dosage is calculated based on the skin area, which is about 0.3g / cm 2 , rotate clockwise and press for 3 minutes to form a carrier layer on the skin. Then, apply the cream evenly on the carrier layer. The dosage is calculated based on the skin area, about 0.6g / cm 2 That is, the amount of the ointment body is about twice that of the carrier. After rotating counterclockwise and pressing for 1 minute, an ointment layer is formed on the carrier layer.

[0052] Example 2: The difference between this example and Example 1 is that: (2) the carrier is prepared, and the preparation method is as follows:

[0053] Calculate the components by mass percentage: 41% of oil, 21% of hydrogel, 13% of fatty alcohol, 4% of emulsifier, 12% of heat-sensitive hydroxypropyl methylcellulose and 9% of water.

[0054] Heat and melt the oil, mix the hydrogel with water, and then add the fatty alcohol. While stirring continuously at 280 r / min, add the emulsifier and then the heat-sensitive hydroxypropyl methylcellulose. Continue stirring at 280 r / min for 20 minutes, then transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 6000 r / min, the temperature is 30°C, and the processing time is 1.2 hours. Then, remove the mixture and place it in a container and cool it naturally to room temperature to obtain the carrier.

[0055] Example 3: The difference between this example and Example 1 is that: (2) the carrier is prepared, and the preparation method is as follows:

[0056] Calculate the components by mass percentage: 41% of oil, 21% of hydrogel, 14% of fatty alcohol, 4% of emulsifier, 13% of heat-sensitive hydroxypropyl methylcellulose and 7% of water.

[0057] Heat and melt the oil, mix the hydrogel with water, and then add the fatty alcohol. While stirring continuously at 280 r / min, add the emulsifier and then the heat-sensitive hydroxypropyl methylcellulose. Continue stirring at 280 r / min for 20 minutes, then transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5000 r / min, the temperature is 30°C, and the processing time is 1.5 hours. Then, remove the mixture and place it in a container and cool it naturally to room temperature to obtain the carrier.

[0058] Example 4: The difference between this example and Example 1 is that: (3) the honeysuckle-gardenia-purslane steam extract is prepared, and the preparation method is as follows:

[0059] A1. Weigh honeysuckle, gardenia, and purslane in a mass ratio of 1:1.1:1.4, mix to obtain a raw material, add 70°C water (4 times the weight of the raw materials), and soak for 1 hour to obtain an soaked material.

[0060] A2. Add 7 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 11 hours to obtain a liquid.

[0061] A3. Concentrate the liquid obtained in A2 to 3 times the total weight of the raw materials, let it stand for 11 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane water vapor extract.

[0062] Example 5: The difference between this example and Example 1 is that: (3) the honeysuckle-gardenia-purslane steam extract is prepared, and the preparation method is as follows:

[0063] A1. Weigh honeysuckle, gardenia, and purslane in a mass ratio of 1:1.2:1.5, mix to obtain a raw material, add 3.5 times the weight of the raw materials in 65°C water, and soak for 1 hour to obtain an soaked material.

[0064] A2. Add 8 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 12 hours to obtain a liquid.

[0065] A3. Concentrate the liquid obtained in A2 to 3 times the total weight of the raw materials, let it stand for 12 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.17 at 60°C, spray dry, collect powder, and grind to obtain the honeysuckle-gardenia-purslane steam extract.

[0066] Example 6: The difference between this example and Example 1 is that: (4) the paste body is prepared, and the preparation method is as follows:

[0067] The components were weighed in parts by weight: 5 parts of Artocarpus nanchuanensis, 4 parts of Scutellaria baicalensis, 2 parts of Phellodendron amurense, 0.3 parts of honeysuckle-gardenia jasminoides-purslane steam extract, 2 parts of Forsythia suspensa, 0.7 parts of Sophora flavescens, 0.5 parts of Dictamnus cortex, 0.5 parts of Kochia scoparia and 5 parts of Artemisia argyi oil.

[0068] Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark, and Kochia scoparia fruit are ground to obtain a mixed fine material; the mixed fine material is mixed with the honeysuckle-gardenia jasminoides-purslane steam extract, and stirred at a stirring speed of 200 r / min for 30 minutes until the mixture is uniformly mixed, and then mugwort oil is added and stirred at a stirring speed of 300 r / min for 30 minutes to mix uniformly to obtain the paste body.

[0069] Example 7: The difference between this example and Example 1 is that: (4) the paste body is prepared, and the preparation method is as follows:

[0070] The components were weighed in parts by weight: 7 parts of Artocarpus nanchuanensis, 5 parts of Scutellaria baicalensis, 3 parts of Phellodendron amurense, 0.5 parts of honeysuckle-gardenia jasminoides-purslane steam extract, 3 parts of Forsythia suspensa, 0.9 parts of Sophora flavescens, 0.8 parts of Dictamnus cortex, 0.8 parts of Kochia scoparia and 6 parts of Artemisia argyi oil.

[0071] Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark, and Kochia scoparia fruit are ground to obtain a mixed fine material; the mixed fine material is mixed with the honeysuckle-gardenia jasminoides-purslane steam extract, and stirred at a stirring speed of 200 r / min for 30 minutes until the mixture is uniformly mixed, and then mugwort oil is added and stirred at a stirring speed of 300 r / min for 30 minutes to mix uniformly to obtain the paste body.

[0072] Comparative Example 1: The difference between this comparative example and Example 1 is that in the preparation of the carrier, the heat-sensitive hydroxypropyl methylcellulose is replaced by hydroxypropyl methylcellulose.

[0073] Specifically, the carrier is prepared, and the preparation method thereof is as follows:

[0074] Calculate the components by mass percentage: 42% oil, 22% hydrogel, 13.5% fatty alcohol, 4.5% emulsifier, 12.5% hydroxypropyl methylcellulose and 5.5% water.

[0075] Heat and melt the oil, mix the hydrogel with water, and then add the fatty alcohol. While stirring continuously at 280 r / min, add the emulsifier and then hydroxypropyl methylcellulose. Continue stirring at 280 r / min for 20 minutes, then transfer to a high-speed homogenizer for homogenization. The speed of the high-speed homogenizer is 5500 r / min, the temperature is 30°C, and the processing time is 1.2 hours. Then, remove the mixture and place it in a container and cool it naturally to room temperature to obtain the carrier.

[0076] Comparative Example 2: The difference between this comparative example and Example 1 is that the heat-sensitive hydroxypropyl methylcellulose is deleted in the carrier preparation.

[0077] Specifically, the carrier is prepared, and the preparation method thereof is as follows:

[0078] Calculate the components by mass percentage: 48% oil, 25.1% hydrogel, 15.4% fatty alcohol, 5.1% emulsifier and 6.4% water.

[0079] Heat and melt the oil, mix the hydrogel with water, and then add the fatty alcohol. Stir continuously at 280 r / min. Add the emulsifier and continue stirring at 280 r / min for 20 minutes. Transfer the mixture to a high-speed homogenizer for homogenization at a speed of 5500 r / min, a temperature of 30°C, and a treatment time of 1.2 hours. Then, remove the mixture and place it in a container, allowing it to cool naturally to room temperature to obtain the carrier.

[0080] Comparative Example 3: The difference between this comparative example and Example 1 is that the carrier is replaced by white vaseline.

[0081] Specifically, the application of anti-allergic cream has the following steps: first, apply white vaseline evenly to the affected area and the surrounding area. The dosage is calculated based on the skin area, which is about 0.3g / cm 2 , rotate clockwise and press for 3 minutes to form a carrier layer on the skin. Then, apply the cream evenly on the carrier layer. The dosage is calculated based on the skin area, about 0.6g / cm 2 That is, the amount of the ointment body is about twice that of white vaseline. After rotating counterclockwise and pressing for 1 minute, an ointment layer is formed on the carrier layer.

[0082] Comparative Example 4: The difference between this comparative example and Example 1 is that the carrier is deleted.

[0083] Specifically, the application of anti-allergic cream, the specific use steps are: apply the cream evenly to the affected area and the surrounding area of the skin, the dosage is calculated based on the skin area, about 0.6g / cm 2 , rotate counterclockwise and press for 1 minute to form an ointment layer.

[0084] Comparative Example 5: This comparative example differs from Example 1 in that, in the preparation of the paste, the honeysuckle-gardenia-purslane steam extract was replaced with a mixture of honeysuckle, gardenia, and purslane steam extracts. The specific steam extraction method / process remained unchanged. Specifically, the three extracts were not mixed together for steam extraction; instead, they were steam extracted separately and then physically mixed.

[0085] Specifically, the paste body is prepared as follows:

[0086] The components were weighed in parts by weight: 6 parts of Artocarpus nanchuanensis, 4.5 parts of Scutellaria baicalensis, 2.5 parts of Phellodendron amurense, 0.13 parts of honeysuckle steam extract, 0.13 parts of Gardenia jasminoides steam extract, 0.13 parts of Portulaca oleracea steam extract, 2.5 parts of Forsythia suspensa, 0.8 parts of Sophora flavescens, 0.7 parts of Dictamnus cortex, 0.6 parts of Kochia scoparia and 5.5 parts of Artemisia argyi oil.

[0087] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark, and Kochia scoparia fruit to obtain a mixed fine material; mix the mixed fine material with honeysuckle steam extract, gardenia jasmine steam extract, and purslane steam extract, and stir at a stirring speed of 200 r / min for 30 minutes until the mixture is uniform, add mugwort oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix uniformly, to obtain the paste body.

[0088] Comparative Example 6: The difference between this comparative example and Example 1 is that the honeysuckle-gardenia-purslane steam extract is deleted in the preparation of the paste.

[0089] Specifically, the paste body is prepared as follows:

[0090] The following components were weighed in parts by weight: 6 parts of Artocarpus nanchuanensis, 4.5 parts of Scutellaria baicalensis, 2.5 parts of Phellodendron amurense, 2.5 parts of Forsythia suspensa, 0.8 parts of Sophora flavescens, 0.7 parts of Dictamnus bark, 0.6 parts of Kochia scoparia fruit and 5.5 parts of Artemisia argyi oil.

[0091] Crush Artocarpus nanchuanensis, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark, and Kochia scoparia fruit to obtain a mixed fine material; stir the mixture at a stirring speed of 200 r / min for 30 minutes until the mixture is uniformly mixed, add mugwort leaf oil, and continue stirring at a stirring speed of 300 r / min for 30 minutes to mix uniformly to obtain the paste.

[0092] Comparative Example 7: The difference between this comparative example and Example 1 is that: in the preparation of the carrier, the heat-sensitive hydroxypropyl methylcellulose is deleted; and in the preparation of the paste body, the honeysuckle-gardenia-purslane steam extract is deleted.

[0093] Test Example 1: Test item: Effect on local skin allergy / itching in mice.

[0094] Test subjects: products obtained in Examples 1-7 and Comparative Examples 1-7.

[0095] Test method: 90 mice, half male and half female, were randomly divided into 15 groups. They were respectively a blank control group (applied with distilled water), Example 1-7 groups (applied with the anti-allergic cream of Example 1-7) and Comparative Example 1-7 groups (applied with the anti-allergic cream of Comparative Example 1-7). The back skin of each mouse was depilated about 4 cm. 2 Then use coarse sandpaper to scratch the shaved area 1cm 2 Each substance was applied to the depilated area. After 10 minutes, 0.01% histamine phosphate solution was dripped onto the abraded surface at a rate of 0.05 ml per mouse. The concentration was then increased every 3 minutes by 0.02%, 0.03%, and 0.04%, with a constant rate of 0.05 ml per mouse each time, until the mouse began to lick. The total amount of histamine phosphate added was used as the itch value, and the average value for each group was recorded and calculated. A higher average itch value indicates a better anti-allergic / antipruritic effect of the applied substance.

[0096] Test results: See Table 1.

[0097] Table 1. Test data of Experiment 1

[0098] Group Average itch value (μg) Blank control group 57.37 Example 1 169.51 Example 2 166.12 Example 3 170.57 Example 4 167.28 Example 5 169.17 Example 6 171.55 Example 7 166.92 Comparative Example 1 152.17 Comparative Example 2 145.43 Comparative Example 3 129.08 Comparative Example 4 134.32 Comparative Example 5 154.28 Comparative Example 6 148.74 Comparative Example 7 131.91

[0099] Result analysis: Analyze the blank control group and Examples 1-7 and combine the data in Table 1 and Figure 1 It can be seen that the effective ingredients of the anti-allergic paste of the present invention are all traditional Chinese medicine components, without side effects, and the use effect can increase the itching value from 57.37 μg in the blank control group to more than 166.92 μg, with significant anti-allergic / antipruritic effects.

[0100] Analyze Comparative Example 3 and Comparative Example 4 and combine the data in Table 1 and Figure 1 It can be seen that the itch value measured in Comparative Example 4 (direct application of the cream of the present invention) is 134.32 μg, while the itch value measured in Comparative Example 3 (application of the cream of the present invention after application of white vaseline as a carrier) is 129.08 μg, that is, applying white vaseline alone as a carrier will cause the anti-allergic / antipruritic effect of the cream of the present invention to decrease instead of increase.

[0101] Analyze Example 1, Comparative Example 1, Comparative Example 2 and Comparative Example 4 and combine the data in Table 1 and Figure 1 It can be seen that when the carrier and the paste body are used together, the addition of hydroxypropyl methylcellulose in the preparation of the carrier of the present invention can improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention; adding hydroxypropyl methylcellulose after preparing the heat-sensitive hydroxypropyl methylcellulose of the present invention can further improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, further improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention.

[0102] Analyze Example 1 and Comparative Examples 5-6 and combine the data in Table 1 and Figure 1 It can be seen that in the preparation of the paste body of the present invention, the addition of honeysuckle water vapor extract, gardenia water vapor extract, and purslane water vapor extract can improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention; steam extraction of honeysuckle, gardenia, and purslane together to obtain the honeysuckle-gardenia-purslane water vapor extract and then adding it can further improve the anti-allergic / antipruritic effect of the paste body of the present invention, that is, further improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention.

[0103] Analyze Example 1, Comparative Example 2, Comparative Example 6 and Comparative Example 7 and combine the data in Table 1 and Figure 1 It can be seen that the addition of heat-sensitive hydroxypropyl methylcellulose in the preparation of the carrier of the present invention and the addition of honeysuckle-gardenia-purslane water vapor extract in the preparation of the paste body of the present invention have a synergistic effect, which can synergistically improve the anti-allergic / antipruritic effect of the anti-allergic paste of the present invention.

[0104] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

[0105] In addition, the various embodiments of the present invention may be arbitrarily combined, and as long as they do not violate the concept of the present invention, they should also be regarded as the contents disclosed by the present invention.

Claims

1. An anti-allergic paste, characterized in that: including a carrier and a paste body; The carrier comprises the following components by mass percentage: 41-44% oil, 21-23% hydrogel, 13-14% fatty alcohol, 4-5% emulsifier, 12-13% heat-sensitive hydroxypropyl methylcellulose and the balance water; The paste body is composed of the following components by weight: 5-7 parts of Nanchuan Wood Peach, 4-5 parts of Scutellaria baicalensis, 2-3 parts of Phellodendron amurense, 0.3-0.5 parts of honeysuckle-gardenia jasminoides-purslane steam extract, 2-3 parts of Forsythia suspensa, 0.7-0.9 parts of Sophora flavescens, 0.5-0.8 parts of Dictamnus cortex, 0.5-0.8 parts of Kochia scoparia fruit and 5-6 parts of Artemisia annua oil.

2. The anti-allergic paste according to claim 1, characterized in that The preparation method of the heat-sensitive hydroxypropyl methylcellulose is as follows: A1. Mix equal amounts of a 7-9% hydroxypropyl methylcellulose aqueous solution and a 7-9% poly (N-isopropylacrylamide) aqueous solution to obtain a mixed solution. A2. Treat the mixture obtained in A1 in a fume hood at 60-70°C until a viscous gel-like substance forms; A3. Transfer the gel-like substance obtained in A2 to an oven, dry it at 85-90°C for 3-5 hours, take it out, grind it into powder, and obtain heat-sensitive hydroxypropyl methylcellulose.

3. The anti-allergic paste according to claim 1, characterized in that The oil comprises one or a mixture of at least two of white vaseline, liquid paraffin and lanolin.

4. The anti-allergic paste according to claim 1, characterized in that The hydrogel is carbomer.

5. The anti-allergic paste according to claim 1, characterized in that: The fatty alcohol includes stearyl alcohol or cetyl alcohol.

6. The anti-allergic paste according to claim 1, characterized in that: The emulsifier includes polysorbate or Span.

7. The anti-allergic paste according to claim 1, characterized in that: The preparation method of the honeysuckle-gardenia-purslane water vapor extract is as follows: A1. Weigh honeysuckle, gardenia, and purslane in a mass ratio of 1:(1-1.2):(1.3-1.5), mix to obtain a raw material, add 65-70°C water (3-4 times the total weight of the raw materials), and soak for 1-2 hours to obtain an infusion. A2. Add 7-8 times the total weight of water to the soaked material obtained in A1, and distill and reflux for 10-12 hours to obtain a liquid; A3. Concentrate the liquid obtained in A2 to 3-3.5 times the total weight of the raw materials, let it stand for 8-12 hours to allow precipitation, and concentrate the supernatant under reduced pressure to a relative density of 1.17 at 60°C. Spray dry the supernatant, collect the powder, and grind it to obtain the honeysuckle-gardenia-portulaca aqueous vapor extract.

8. A method for preparing the anti-allergic paste according to any one of claims 1 to 7, characterized in that: The steps include: S1. Prepare a carrier; Heat and melt the oil, mix the hydrogel with water, add fatty alcohol after mixing, add emulsifier while continuing to stir, add heat-sensitive hydroxypropyl methylcellulose, transfer to a high-speed homogenizer for homogenization, and naturally cool to room temperature to obtain the carrier; S2, preparing the paste body; Nanchuan Muboluo, Scutellaria baicalensis, Phellodendron amurense, Forsythia suspensa, Sophora flavescens, Dictamni bark and Kochia scoparia fruit are crushed to obtain a mixed fine material; the mixed fine material is evenly mixed with the honeysuckle-gardenia jasminoides-purslane steam extract, and mugwort oil is added and continuously stirred to mix to obtain the paste.

9. The method for preparing the antiallergic paste according to claim 8, characterized in that: In S1, the speed of the high-speed homogenizer is 5000-6000 r / min, the temperature is 28-30° C., and the processing time is 1-1.5 h.

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