Alcohol disinfectant with color change indication function and preparation method

Abstract

The invention discloses an alcohol disinfectant with a color change indication function and a preparation method, and belongs to the technical field of disinfectants, the alcohol disinfectant is characterized by comprising the following components by weight: 0.1-0.3% (w / v) of a reducing agent, 0.05-0.07 mol / L of an indicator, 0.08-0.12% (w / v) of a reaction aid, 1.6-1.8% (w / v) of a skin care agent, 70% (v / v) of ethanol, and a solvent water; the alcohol disinfectant has the beneficial effects that 1, the alkaline Tibetan red, the glucose and the fatty alcohol-polyoxyethylene ether are used in the alcohol disinfectant, so that the sterilizing effect of the prepared disinfectant is not influenced; 2, the initial liquid is colorless and transparent, becomes red after acting with oxygen in air, and becomes colorless after a period of time; and 3, in a colorless-red-colorless changing process of the disinfectant, the color changing time can be controlled by adjusting the proportion of the disinfectant, so that the disinfectant disclosed by the invention has a relatively good flexible application effect.

Description

Technical field:

[0001] The invention belongs to the technical field of disinfectants, and more specifically relates to an alcohol disinfectant with a color change indication function and a preparation method thereof. Background technology:

[0002] In the field of medical infection control, alcohol disinfectants are commonly used skin disinfectant products. Skin disinfectants should have the characteristics of quick drying, broad-spectrum bactericidal, non-irritating, and skin care, and medical staff need to strictly follow the specifications. When using disinfection products for skin disinfection, there is a problem of being unable to judge whether medical staff strictly meet the disinfection operation standards, and the disinfectant cannot be visually monitored. Therefore, it is necessary to develop a disinfectant with a color change indication function that can monitor whether the disinfection process can meet the standard requirements. Summary of the invention:

[0003] In order to solve the above problems and overcome the shortcomings of the prior art, the present invention provides a skin disinfectant with a color change indication function and a preparation method thereof. The present invention can be well applied to the skin disinfection process of medical personnel, and the standardization of the disinfection operation can be judged by the change of color, and the visualization function characteristics of disinfection are intended to be developed. The prepared disinfectant can change color in the air, and the color change process time can be controlled by adjusting the raw material ratio of the disinfectant. At the same time, it has good broad-spectrum bactericidal ability, has the advantages of strong operability and strong indication effect, and can be applied to the field of medical infection control.

[0004] The specific technical solution of the present invention to solve the above technical problems is: an alcohol disinfectant with a color change indication function, characterized by being composed of the following components in parts by weight: 0.1-0.3% (w / v) reducing agent, 0.05-0.07 mol / L indicator, 0.08-0.12% (w / v) reaction aid, 1.6-1.8% (w / v) skin care agent, 70% (v / v) ethanol, and the solvent is water;

[0005] The reducing agent is glucose; the indicator is alkaline saffron; and the reaction auxiliary agent is fatty alcohol polyoxyethylene ether.

[0006] Furthermore, the skin care agent is glycerin or allantoin or a mixture of the two.

[0007] Furthermore, the alcohol disinfectant can have a bactericidal effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, or Candida albicans.

[0008] Furthermore, the alcohol disinfectant is colorless, and after contacting with oxygen in the air, it takes 25s-2min for it to change from colorless to red, and it takes 55s-5min for it to fade from red to colorless.

[0009] A method for preparing an alcohol disinfectant with a color change indication function, characterized in that the preparation of the alcohol disinfectant comprises the following steps:

[0010] (1) Mix and dilute the reducing agent and deionized water in proportion;

[0011] (2) Under nitrogen protection, take the indicator and the mixed solution and stir them thoroughly;

[0012] (3) Under nitrogen protection, ethanol, a skin care agent and a reaction aid are added to the mixed solution in sequence, and after sufficient stirring and mixing, the disinfectant having a color change indicating function is obtained.

[0013] Further comprising the following steps:

[0014] (1) mixing and diluting a 20% (w / v) glucose solution with deionized water in a mass ratio of 1:67.7-200;

[0015] (2) Under nitrogen protection, 0.05-0.07 parts by weight of 1 mol / L alkaline saffron solution was added to the above mixture and stirred thoroughly;

[0016] (3) Under nitrogen protection, 70% (v / v) ethanol, 0.08-1.0% (w / v) glycerol, 0.08-1.0% (w / v) allantoin, and 0.08-0.12% (w / v) fatty alcohol polyoxyethylene ether are added to the mixed solution in sequence, and the mixture is stirred and mixed to obtain the disinfectant having a color change indication function.

[0017] A use of an alcohol disinfectant with a color change indication function. The alcohol disinfectant is used in a skin hygiene disinfection process. After the alcohol disinfectant is exposed to air for a period of time, the color of the alcohol disinfectant changes from colorless to red to colorless. The color change of the alcohol disinfectant can provide a visual indication of the time requirement of the disinfection operation process for medical personnel.

[0018] The beneficial effects of the present invention are:

[0019] The disinfectant prepared by the present invention has the following advantages: 1. Alkaline crocin, glucose and fatty alcohol polyoxyethylene ether are used in the alcohol disinfectant, and the sterilization effect of the prepared disinfectant is not affected; 2. The initial liquid is colorless and transparent, and turns red after reacting with oxygen in the air, and turns back to colorless after a period of time; 3. During the change process of the disinfectant from colorless-red-colorless, the color change time can be controlled by adjusting the ratio of the disinfectant, so that the disinfectant of the present invention has a better flexible application effect;

[0020] The disinfectant prepared by the present invention has a color change indication principle in which, under the action of the reaction auxiliary fatty alcohol polyoxyethylene ether, alkaline saffron undergoes an oxidation-reduction reaction with oxygen in the air to cause a color change, and is then reduced by glucose to become colorless, thereby causing the disinfectant to change color; the fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant present more stable physical and chemical properties, but also can achieve controllable adjustment of the color change cycle, thereby adapting to the need for visual indication of the disinfection operation process time requirement of medical personnel through the color change of the alcohol disinfectant;

[0021] Compared with the prior art, the present invention has a more significant application effect: when alcohol disinfectant is used in the process of skin hygiene disinfection, the color of the alcohol disinfectant changes from colorless to red to colorless after being in contact with the air for a period of time. The color change of the alcohol disinfectant can provide a visual indication of the time nodes of the disinfection operation process for medical staff. Description of the drawings:

[0022] Attached Figure 1 This is a diagram of the color change process of the alcohol disinfectant in Example 1 of the present invention;

[0023] Attached Figure 2 This is a diagram of the color change process of the alcohol disinfectant in Example 2 of the present invention;

[0024] Attached Figure 3 This is a diagram of the color change process of the alcohol disinfectant in Example 3 of the present invention;

[0025] Attached Figure 4 This is a diagram of the color change process of the alcohol disinfectant in Example 4 of the present invention;

[0026] Attached Figure 5 This is a diagram of the color change process of the alcohol disinfectant in Example 5 of the present invention;

[0027] Attached Figure 6 This is a diagram of the color development process of the alcohol disinfectant in Comparative Example 1 of the present invention;

[0028] Attached Figure 7 This is a diagram of the color development process of the alcohol disinfectant in Comparative Example 2 of the present invention;

[0029] Attached Figure 8 This is a diagram of the color change process of the alcohol disinfectant in Comparative Example 3 of the present invention;

[0030] Attached Fig. 9 It is a usage state diagram of the alcohol disinfectant with color change indication function of the present invention; Specific implementation method:

[0031] In the description of the present invention, specific details are only for a full understanding of the embodiments of the present invention, but those skilled in the art should know that the implementation of the present invention is not limited to these details. In addition, well-known structures and functions are not described or shown in detail to avoid blurring the key points of the embodiments of the present invention. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0032] Specific implementation of the present invention:

[0033] In order to better understand the present invention, a specific embodiment is used for illustration. It is worth emphasizing that the effect of this embodiment is not substantially different from the various embodiments within the protection scope of the present invention, including the respective reagents and the content ratio of the reagents, and all of them can achieve the effects described in the present invention and solve the above-mentioned problems. Other combinations are not described here.

[0034] Embodiment 1: By weight, the preparation method comprises the following steps:

[0035] 0.1% (w / v) glucose, 0.05 mol / L alkaline saffron, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0036] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water in a mass ratio of 1:200 for mixing and diluting; under the condition of nitrogen protection, take 0.05 weight part of 1 mol / L alkaline saffron solution; and stir and mix it with the above mixed solution; under the condition of nitrogen protection, add 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.08% (w / v) fatty alcohol polyoxyethylene ether to the above mixed solution in sequence, stir and mix them thoroughly, and obtain the disinfectant with fading indication function.

[0037] The disinfectant prepared in Example 1 was placed in a test tube and exposed to oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 2 minutes; the time for it to change from red to colorless was 5 minutes. Figure 1 ;

[0038] Embodiment 2: According to weight percentage, the preparation method comprises the following steps:

[0039] 0.2% (w / v) glucose, 0.06 mol / L alkaline saffron, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.10% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0040] A glucose solution with a mass concentration of 20% (w / v) is mixed and diluted with deionized water in a mass ratio of 1:100; under the condition of nitrogen protection, 0.06 weight parts of 1 mol / L alkaline saffron solution are taken and fully stirred and mixed with the above mixed solution; under the condition of nitrogen protection, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.10% (w / v) fatty alcohol polyoxyethylene ether are added to the above mixed solution in sequence, and after fully stirring and mixing, the disinfectant with fading indication function is obtained.

[0041] The disinfectant prepared in Example 2 was placed in a test tube and exposed to oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 1 min; the time for it to change from red to colorless was 3 min. Figure 2 ;

[0042] Embodiment 3: According to weight percentage, the preparation method comprises the following steps:

[0043] 0.3% (w / v) glucose, 0.06 mol / L alkaline saffron, 70% (v / v) ethanol, 0.8% (w / v) glycerol, 0.8% (w / v) allantoin, 0.12% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0044] A glucose solution with a mass concentration of 20% (w / v) is mixed and diluted with deionized water in a mass ratio of 1:66.7; under nitrogen protection, 0.06 weight parts of 1 mol / L alkaline saffron solution are taken and fully stirred and mixed with the above mixed solution; under nitrogen protection, 70% (v / v) ethanol, 0.8% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.12% (w / v) fatty alcohol polyoxyethylene ether are added to the above mixed solution in sequence, and after fully stirring and mixing, the disinfectant with fading indication function is obtained.

[0045] The disinfectant prepared in Example 3 was placed in a test tube and exposed to oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 30 seconds; the time for it to change from red to colorless was 1 minute. Figure 3 ;

[0046] Embodiment 4: According to weight percentage, the preparation method comprises the following steps:

[0047] 0.1% (w / v) glucose, 0.06 mol / L alkaline saffron, 70% (v / v) ethanol, 0.8% (w / v) glycerol, 1.0% (w / v) allantoin, 0.09% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0048] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water in a mass ratio of 1:200 for mixing and diluting; under the condition of nitrogen protection, take 0.06 weight parts of 1 mol / L alkaline saffron solution and stir and mix it with the above mixed solution; under the condition of nitrogen protection, add 70% (v / v) ethanol, 0.8% (w / v) glycerol, 1.0% (w / v) allantoin, and 0.09% (w / v) fatty alcohol polyoxyethylene ether to the above mixed solution in sequence, stir and mix thoroughly, and obtain the hand disinfectant with fading indication function.

[0049] The hand disinfectant prepared in Example 4 was placed in a test tube and exposed to oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 45 seconds; the time for it to change from red to colorless was 2.5 minutes. Figure 4 ;

[0050] Embodiment 5: By weight, the preparation method comprises the following steps:

[0051] 0.3% (w / v) glucose, 0.07 mol / L alkaline saffron, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.085% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0052] A glucose solution with a mass concentration of 20% (w / v) is mixed and diluted with deionized water in a mass ratio of 1:66.7; under nitrogen protection, 0.07 weight parts of 1 mol / L alkaline saffron solution is taken and fully stirred and mixed with the above mixed solution; under nitrogen protection, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.085% (w / v) fatty alcohol polyoxyethylene ether are sequentially added to the above mixed solution, and after sufficient stirring and mixing, the disinfectant with fading indication function is obtained.

[0053] The disinfectant prepared in Example 5 was placed in a test tube and exposed to oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 25 seconds; the time for it to change from red to colorless was 55 seconds. Figure 5 ;

[0054] The disinfectant prepared in Examples 1-5 was placed in a test tube to contact with oxygen in the air. Since the contact area between the test tube and oxygen was limited, the test tube was slightly shaken to increase the interaction between the disinfectant and oxygen, and the shaking frequency and time were fixed; the disinfectant was observed at room temperature.

[0055] Table 1: Color change time and bactericidal effect results of different examples

[0056]

[0057] Table 2: Tests of different harmful bacteria sterilization performance of different embodiments

[0058]

[0059] From the data analysis of Table 1 and Table 2, we can see that:

[0060] (1) The hand disinfectants prepared in Examples 1-5 were tested for their bactericidal properties in accordance with the Technical Specifications for Disinfection (2002 Edition). Bactericidal tests were conducted on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and other bacteria. The test results all met the requirements of the Technical Specifications for Disinfection (2002 Edition) for qualified disinfection.

[0061] (2) The disinfectant prepared by the present invention has a color change indication principle in which, under the action of the reaction auxiliary fatty alcohol polyoxyethylene ether, alkaline saffron undergoes an oxidation-reduction reaction with oxygen in the air to cause a color change, and is then reduced by glucose to become colorless, thereby causing the disinfectant to change color; fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant present more stable physical and chemical properties, but also can achieve controllable adjustment of the color change cycle, especially the fading time from red to colorless is 55S-5min, which can meet the need for visual indication of the time requirements of the disinfection operation process of medical personnel through the color change of the alcohol disinfectant; visual indication of the time nodes of the disinfection operation process of medical personnel is achieved through the color change of the alcohol disinfectant.

[0062] In order to more intuitively demonstrate the process advantages of the present invention, the present invention uses an alcohol disinfectant with a color change indication function and the same process uses an equivalent replacement method for comparison.

[0063] Comparative Example 1: The preparation method is the same as that of the embodiment, except that in the preparation process of this comparative example, the indicator is replaced by: methyl red, methylene red, bromocresol green, thymol blue solution;

[0064] 0.1% (w / v) glucose, 0.05 mol / L indicator, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether, the solvent is water. The indicator includes: methyl red, methylene red, bromocresol green, thymol blue solution.

[0065] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water at a mass ratio of 1:200 and mix and dilute them; under the protection of nitrogen, take 0.05 weight parts of 1 mol / L indicator solution and stir and mix them with the above mixed solution; under the protection of nitrogen, add 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether to the above mixed solution in sequence, stir and mix them thoroughly, and obtain a disinfectant. The color of the disinfectant does not change before and after. Figure 6 It can be seen that when the indicator is selected as methyl red, methylene red, bromocresol green, or thymol blue solution, the color of the disinfectant will not change.

[0066] Comparative Example 2: The preparation method is the same as that of the embodiment, except that no reducing agent, glucose, is added during the preparation of this comparative example;

[0067] The preparation method of ethanol hand disinfectant comprises the following steps by weight:

[0068] 0.05mol / L alkaline saffron, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether, the solvent is water.

[0069] Under nitrogen protection, 0.05 weight parts of 1 mol / L indicator solution were added to 70% (v / v) ethanol solution, and 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.08% (w / v) fatty alcohol polyoxyethylene ether were added in sequence. After sufficient stirring, a disinfectant solution was obtained. The color change of the disinfectant solution before and after is as follows Figure 7 It can be seen that when glucose is not added to the disinfectant, the color of the disinfectant will not change.

[0070] Comparative Example 3: The preparation method is the same as that of the embodiment, except that: in the preparation process of this comparative example, no reaction aid is added: fatty alcohol polyoxyethylene ether;

[0071] The preparation method of the ethanol disinfectant comprises the following steps by weight:

[0072] 0.1-0.3% (w / v) glucose, 0.05-0.07 mol / L alkaline saffron, 70% (v / v) ethanol, 0.8-1.0% (w / v) glycerol, 0.8-1.0% (w / v) allantoin, and the solvent is water.

[0073] A glucose solution with a mass concentration of 20% (w / v) is mixed and diluted with deionized water in a mass ratio of 1:200; under nitrogen protection, 0.05 weight parts of a 1 mol / L indicator alkaline safflower solution is added to a 70% (v / v) ethanol solution, and 1.0% (w / v) glycerol and 0.8% (w / v) allantoin are added in sequence, and the mixture is fully stirred to obtain a disinfectant.

[0074] The disinfectant prepared in Comparative Examples 1-3 was placed in a test tube to contact with oxygen in the air. Since the contact area between the test tube and oxygen was limited, the test tube was slightly shaken to increase the interaction between the disinfectant and oxygen, and the shaking frequency and time were fixed; the disinfectant was observed at room temperature;

[0075] Table 3: Comparison of color development effects of different embodiments and comparative examples

[0076]

[0077] From the data analysis of Tables 1 and 3, we can see that:

[0078] (1) After the alcohol disinfectant prepared in Examples 1-5 is exposed to air for a period of time, the color changes from colorless to red to colorless. The color change of the alcohol disinfectant can provide a visual indication of the time nodes of the disinfection operation process for medical staff.

[0079] (2) Comparative Example 1 and Comparative Example 2: Both failed to achieve a fading effect, and failed to meet the need to visually indicate the time requirements of the disinfection operation process of medical personnel through the color change of the alcohol disinfectant; that is, visually indicate the time requirements of the disinfection operation process of medical personnel through the color change of the alcohol disinfectant;

[0080] (3) In Comparative Example 3, since fatty alcohol polyoxyethylene ether is not added to the disinfectant, the color change indication function of the disinfectant fails, and the solution turns yellow and cannot be restored. This cannot meet the need for visual indication of the disinfection operation time requirements of medical staff through the color change of the alcohol disinfectant, that is, visual indication of the disinfection operation time requirements of medical staff through the color change of the alcohol disinfectant;

[0081] In order to more intuitively demonstrate the process advantages of the present invention, the present invention uses an alcohol disinfectant with a color change indication function and also uses a color development effect in a simulated skin hygiene disinfection process.

[0082] Table 4: Comparison of color development effects of different embodiments and comparative examples

[0083]

[0084] As shown in Table 4, the alcohol disinfectant of the present invention can be applied to different skin colors, including black, yellow or white skin colors, and has an obvious color change effect, which can meet the time requirements of the disinfection operation process of medical staff and realize the need for visual indication;

[0085] Moreover, according to the practical results, it can be known that: by adopting the color change time of the color development effect simulated in the skin hygiene disinfection process and placing the disinfectant in the test tube in contact with oxygen in the air and slightly shaking the test tube to increase the effect of the disinfectant and oxygen, the difference is not much compared with the color change time of the color development effect with a fixed shaking frequency and time, especially the fading time from red to colorless is not different, which can meet the need of visual indication of the disinfection operation process time requirements of medical personnel through the color change of the alcohol disinfectant, that is, the visual indication of the disinfection operation process time nodes of medical personnel is achieved through the color change of the alcohol disinfectant;

[0086] In order to more intuitively demonstrate the process advantages of the present invention, the present invention uses an alcohol disinfectant with a color change indication function to further study the compatibility of the color change time of the embodiment and comparative example 3 with the time nodes of the disinfection operation process.

[0087] Comparative Example 3-1: The preparation method is the same as that of Example 1, except that: in the preparation process of this comparative example, no reaction aid is added: fatty alcohol polyoxyethylene ether;

[0088] Comparative Example 3-2: The preparation method is the same as that of Example 2, except that: in the preparation process of this comparative example, no reaction aid is added: fatty alcohol polyoxyethylene ether;

[0089] Comparative Example 3-3: The preparation method is the same as that of Example 3, except that: in the preparation process of this comparative example, no reaction aid is added: fatty alcohol polyoxyethylene ether;

[0090] Comparative Example 3-4: The preparation method is the same as that of Example 4, except that: in the preparation process of this comparative example, no reaction aid is added: fatty alcohol polyoxyethylene ether;

[0091] Comparative Example 3-5: The preparation method is the same as that of Example 5, except that: in the preparation process of this comparative example, no reaction aid is added: fatty alcohol polyoxyethylene ether;

[0092] Table 5: Comparison of color development effects of different embodiments and comparative examples

[0093]

[0094] It can be seen from Table 5 that fatty alcohol polyoxyethylene ether is creatively added in Examples 1-5. Fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant present more stable physical and chemical properties, but also can achieve controllable adjustment of the color change cycle, especially the fading time from red to colorless is 55S-5min, and the controllable range of fading time is wide, which can meet the need for visual indication of the time requirements of the disinfection operation process of medical staff through the color change of the alcohol disinfectant; visual indication is achieved through the requirements of the time nodes of the disinfection operation process of medical staff by the color change of the alcohol disinfectant.

[0095] Although comparative examples 1-5 obtain a non-red-yellow color change effect, the color difference between yellow and skin color is small and difficult to observe. More importantly, it can be seen from the data in Table 5 that although the non-red-yellow color change effect is also obtained without the addition of fatty alcohol polyoxyethylene ether, the fading time from red to yellow is 18S-30S, and the fading time cannot be increased to a greater extent after adjustment. The fading time is short, which cannot meet the need for visual indication of the time requirements of the disinfection operation process of medical staff through the color change of the alcohol disinfectant; the visual indication of the time nodes of the disinfection operation process of medical staff through the color change of the alcohol disinfectant is realized.

[0096] In summary:

[0097] The disinfectant prepared by the present invention has the following advantages: 1. Alkaline crocin, glucose and fatty alcohol polyoxyethylene ether are used in the alcohol disinfectant, and the sterilization effect of the prepared disinfectant is not affected; 2. The initial liquid is colorless and transparent, and turns red after reacting with oxygen in the air, and turns back to colorless after a period of time; 3. During the change process of the disinfectant from colorless-red-colorless, the color change time can be controlled by adjusting the ratio of the disinfectant, so that the disinfectant of the present invention has a better flexible application effect;

[0098] The disinfectant prepared by the present invention has a color change indication principle in which, under the action of the reaction auxiliary fatty alcohol polyoxyethylene ether, alkaline saffron undergoes an oxidation-reduction reaction with oxygen in the air to cause a color change, and is then reduced by glucose to become colorless, thereby causing the disinfectant to change color; the fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant present more stable physical and chemical properties, but also can achieve controllable adjustment of the color change cycle, thereby adapting to the need for visual indication of the disinfection operation process time requirement of medical personnel through the color change of the alcohol disinfectant;

[0099] Compared with the prior art, the present invention has a more significant application effect: when alcohol disinfectant is used in the process of skin hygiene disinfection, the color of the alcohol disinfectant changes from colorless to red to colorless after being in contact with the air for a period of time. The color change of the alcohol disinfectant can provide a visual indication of the time nodes of the disinfection operation process for medical staff.

Claims

1. A method for preparing an alcohol disinfectant having a color change indication function, characterized in that The following steps are involved: (1) Mix and dilute the reducing agent and deionized water in proportion; (2) Under nitrogen protection, take the indicator and the mixed solution and stir them thoroughly; (3) Under nitrogen protection, ethanol, a skin care agent and a reaction aid are added to the above mixed solution in sequence, and after being fully stirred and mixed, an alcohol disinfectant having a color change indication function is obtained.

2. The method for preparing the alcohol disinfectant with color change indication function according to claim 1, characterized in that The following steps are involved: (1) mixing and diluting a 20% w / v glucose solution with deionized water in a mass ratio of 1:66.7 to 1:200; (2) Under nitrogen protection, 0.05-0.07 parts by weight of 1 mol / L alkaline saffron solution was added to the above mixture and stirred thoroughly; (3) Under nitrogen protection, 70% v / v ethanol, 0.08-1.0% w / v glycerol, 0.08-1.0% w / v allantoin, and 0.08-0.12% w / v fatty alcohol polyoxyethylene ether are added to the mixed solution in sequence, and after sufficient stirring and mixing, an alcohol disinfectant with a color change indication function is obtained.

3. The method for preparing the alcohol disinfectant with color change indication function according to claim 1, characterized in that The alcohol disinfectant with color change indication function is composed of the following components in parts by weight: 0.1-0.3% w / v reducing agent, 0.05-0.07 mol / L indicator, 0.08-0.12% w / v reaction aid, 70% v / v ethanol, and the solvent is water; The reducing agent is glucose; the indicator is alkaline saffron; and the reaction auxiliary agent is fatty alcohol polyoxyethylene ether.

4. The method for preparing the alcohol disinfectant with color change indication function according to claim 3, characterized in that: The alcohol disinfectant can have a bactericidal effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa or Candida albicans.

5. The method for preparing the alcohol disinfectant with color change indication function according to claim 3, characterized in that: Also included is 1.6-1.8% w / v of a skin-protecting agent, which is glycerin or allantoin or a mixture of the two.

6. The method for preparing the alcohol disinfectant with color change indication function according to any one of claims 1 to 5, characterized in that: The alcohol disinfectant is colorless, and after contacting with oxygen in the air, it takes 25s-2min for it to change from colorless to red, and it takes 55s-5min for it to fade from red to colorless.

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