Eye detection device and method

Abstract

The invention relates to an eyeball optical measuring instrument, in particular to an eye detection device and method. The device comprises a system light source module used for emitting light; the anterior chamber corneal lens is provided with an incident surface, a first reflecting surface and a concave part used for being matched with an eyeball, and the first reflecting surface is arranged on one side of the concave part; the anterior chamber corneal lens receives light rays emitted by the system light source module through the incident plane and reflects the light rays to the concave part through the first reflecting plane, so that the light rays pass through the anterior chamber or cornea of the eyeball located at the concave part; and the first light acquisition module is arranged towards the concave part. According to the eye detection device, the light source can enter and scan the cornea and the anterior chamber in a safe mode, and the risk that the incident light directly penetrates through scattered pupils to enter the fundus of the vitreous body is avoided; meanwhile, the detection range and content of the disease marker are widened, so that more diagnosis basis is provided for eye detection.

Description

Technical Field

[0001] The present invention relates to an eye detection instrument, and in particular to an eye detection device and method. Background Art

[0002] Slit lamp microscope is a commonly used non-invasive ophthalmic examination device. It can magnify the ocular structure and examine ocular lesions to guide clinical diagnosis, such as glaucoma, cataracts, pigment exfoliation syndrome, vitreous opacities, ocular surface and intraocular inflammation, etc. Ophthalmologists can also use slit lamp microscope to evaluate the condition, such as the inflammatory process of the anterior segment of the eye (the iris of the eye and the parts before it: cornea, anterior chamber, iris, pupil, lens, ciliary body, etc.), the degree of changes in ocular tissue and structure, and the density of non-inflammatory suspended particles.

[0003] The blood-ocular barrier is composed of the blood-aqueous barrier (BAB) and the blood-retinal barrier. The BAB is composed of the non-pigmented epithelium of the ciliary body and the capillary endothelial cells of the iris. Pathological processes in the eye can damage its barrier function. When an inflammatory response occurs in the eye or the whole body, the blood-ocular barrier function of the BAB will be affected, causing medium to large molecular weight blood components such as serum proteins and blood cells to penetrate into the aqueous humor (the aqueous humor is the fluid that fills the anterior chamber of the eye). The degree of deterioration of the BAB barrier function depends on the severity of the intraocular or systemic inflammatory activity. The stronger the inflammatory response, the more protein and blood cells will aggregate and deposit in the aqueous humor. Under a slit lamp microscope, this pathological process manifests as suspended bright spots (flares) with various densities and movements that gather in the anterior chamber of the eye. Intraocular suspended matter can also occur in other eye diseases that are not dominated by inflammatory reactions, such as pigment dissemination syndrome and exfoliation syndrome.

[0004] The principle of observing flares with a slit lamp microscope is based on the light scattering phenomenon caused by proteins, cells or other particles in the aqueous humor. Clinicians can subjectively observe the density of flares with the naked eye through a slit lamp microscope to infer the content of proteins, other visible particles or blood cells in the aqueous humor, thereby assessing the severity of the disease. However, precisely because of the subjective and difficult-to-quantify characteristics of slit lamp microscopy, there will be obvious differences between doctors, and clinical examination results are difficult to fully quantify and compare, which adds inaccuracy to the clinical diagnosis and follow-up of the disease. In view of these shortcomings, an objective and quantitative method is needed in clinic. Innovative detection methods need to have several elements: minimally invasive (or non-invasive), good repeatability and accuracy, good operability and biocompatibility (including shorter detection time). Summary of the invention

[0005] In view of the above problems of the prior art slit lamp microscope, the present application provides an eye detection device and a detection method, which can enable the light source to be incident on and scan the cornea and anterior chamber in a safe manner, avoiding the risk of the incident light directly passing through the pupil into the vitreous body and irradiating the fundus and retina, and can broaden the detection range, detection types and detection contents of markers, thereby providing more and more accurate basis for eye and systemic diagnosis, follow-up and evaluation.

[0006] A first aspect of the present application provides an eye detection device, comprising:

[0007] System light source module 2, used for emitting light;

[0008] The anterior chamber keratometer 4 is provided with an incident surface 41, a first reflecting surface 42 and a recessed portion 43 for fitting the eyeball, wherein the first reflecting surface 42 is arranged on one side of the recessed portion 43; the anterior chamber keratometer 4 receives the light emitted by the system light source module 2 through the incident surface 41, and reflects the light to the recessed portion 43 through the first reflecting surface 42, so that the light passes through the anterior chamber of the eyeball located at the recessed portion 43; the first light collection module 5 is arranged toward the recessed portion 43.

[0009] In this embodiment, the anterior chamber keratometer is designed so that light can pass through the anterior chamber of the eyeball located at the concave portion at a safe angle, thereby avoiding the risk of incident light directly passing through the dilated pupil and entering the vitreous fundus.

[0010] In some embodiments, the anterior chamber keratoscope 4 is further provided with a second reflecting surface 44, which is provided on the other side of the concave portion 43 relative to the first reflecting surface 42; the light passing through the anterior chamber of the eyeball is reflected by the second reflecting surface 44, and the reflected light is emitted through the incident surface 41 of the anterior chamber keratoscope 4;

[0011] A second light collection module 6 is arranged facing the direction in which the light is emitted from the incident surface 41 .

[0012] In this embodiment, the light scattered in the anterior chamber collected by the first light collection module 5 and the light passing through the anterior chamber collected by the second light collection module 6 can broaden the detection range, detection types and detection contents of disease markers based on the combination of dynamic light scattering and multiple light scattering, thereby providing more, more comprehensive and more objective diagnostic basis for eye detection.

[0013] In some embodiments, the anterior chamber keratoscope 4 is further provided with a light-stopping element 45 , which is disposed on the other side of the recess 43 relative to the first reflecting surface 42 ; the light passing through the anterior chamber of the eyeball is absorbed by the light-stopping element 45 .

[0014] In this embodiment, a light-stopping element is provided in the anterior chamber corneal lens, and the light passing through the anterior chamber and reaching the light-stopping element 45 will be absorbed, so as to prevent the light passing through the anterior chamber from affecting the light collection of the first light collection module 5 .

[0015] In some embodiments, it further comprises:

[0016] A second micro-motion platform 3, on which an anterior chamber keratoscope 4, a first light collection module 5 and / or a second light collection module 6 are arranged;

[0017] A first pressure sensor (7) for sensing the force applied to the second micro-motion platform (3);

[0018] A second pressure sensor (8) for sensing the force applied to the anterior chamber keratoscope (4);

[0019] The second driving device is used to drive the second fine-motion platform 3 to adjust according to the force conditions.

[0020] In this embodiment, by providing a pressure sensor, the position of the anterior chamber keratoscope can be adjusted based on the signal of the pressure sensor, which can improve the detection accuracy and the examiner's experience.

[0021] In some embodiments, a first micro-motion platform 1 is provided with a system light source module 2 and a second micro-motion platform 3;

[0022] The first driving device is used to drive the first fine-motion platform 1 to adjust according to the force conditions, and the adjustment range is greater than the adjustment range of the second fine-motion platform 3.

[0023] In this embodiment, the first fine-motion platform 1 and the second fine-motion platform 3 are adjusted based on the signal of the pressure sensor 8, so as to improve the detection accuracy and the experience of the examiner.

[0024] In some implementations, the third driving device is used to drive the system light source module 2 to make adjustments.

[0025] In this embodiment, the system light source module 2 is adjustable, and the angle of the incident light can be adjusted accurately and flexibly.

[0026] A second aspect of the present application provides an eye detection method based on the above-mentioned eye detection device, comprising:

[0027] The light is emitted through the system light source module 2;

[0028] The first light collection module 5 collects the first light and shadow of the anterior chamber of the eyeball located at the concave portion 43 of the anterior chamber keratometer 4, wherein the first light and shadow includes the light and shadow when the light passes through the anterior chamber of the eyeball;

[0029] Eyes are detected based on the first shading.

[0030] In some embodiments, the second light collection module 6 is further included to collect the second light reflected by the second reflection surface 44 of the anterior chamber keratometer 4 and emitted from the incident surface 41 of the anterior chamber keratometer 4;

[0031] The eye is also detected based on the second light shade.

[0032] In some embodiments, it further includes: adjusting the direction of light emitted by the system light source module 2 by at least one of the following methods;

[0033] The first driving device drives the first micro-motion platform 1 to adjust,

[0034] The second driving device drives the second micro-motion platform 3 to adjust,

[0035] The system light source module 2 is driven by the third driving device to be adjusted.

[0036] In some embodiments, it further comprises:

[0037] The force condition of the second micro-motion platform 3 is sensed by the first pressure sensor 7, and the force condition of the anterior chamber keratoscope 4 is sensed by the second pressure sensor 8;

[0038] The second fine motion platform 3 is driven to adjust according to the force conditions, and / or the first fine motion platform 1 is driven to adjust according to the force conditions, and the adjustment range is greater than the adjustment range of the second fine motion platform 3 .

[0039] These and other aspects of the invention will become apparent from the following description of the embodiment(s). BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The following further illustrates the various features of the present invention and the relationship between the various features with reference to the accompanying drawings. The accompanying drawings are all exemplary, some features are not shown in actual proportion, and some drawings may omit the conventional features in the field involved in the present application and are not necessary for the present application, or additionally show the features that are not necessary for the present application. The combination of the various features shown in the accompanying drawings is not intended to limit the present application. In addition, throughout this specification, the same figure numerals refer to the same content. The specific description of the drawings is as follows:

[0041] Figure 1 It is a schematic diagram of the detection performed by the existing anterior chamber detection instrument;

[0042] Figure 2 is a schematic diagram of the structure of an eye detection device provided in an embodiment of the present application;

[0043] Figure 3is a schematic structural diagram of a comprehensive irradiation system provided in an embodiment of the present application;

[0044] Figure 4 is a schematic structural diagram of a white light irradiation system provided in an embodiment of the present application;

[0045] Figure 5 is a schematic structural diagram of a laser irradiation system provided in an embodiment of the present application;

[0046] Figure 6 is a schematic diagram of the coupling between the anterior chamber keratoscope and the anterior chamber of the eye provided by this embodiment of the present application;

[0047] Figure 7 It is a schematic diagram of the structure of the anterior chamber keratoscope provided in an embodiment of the present application;

[0048] Figure 8 is a schematic structural diagram of a variable lens provided in an embodiment of the present application;

[0049] Fig. 9 It is a structural schematic diagram of a filter group and a filter group control component provided in an embodiment of the present application;

[0050] Fig.10 is a schematic diagram of the structure of a computing device provided in an embodiment of the present application;

[0051] Fig.11 is a schematic structural diagram of anterior chamber keratoscope provided in another embodiment of the present application;

[0052] Fig.12 It is a schematic diagram of the eye detection method provided in an embodiment of the present application. DETAILED DESCRIPTION

[0053] The technical solution provided by the present application is further described below with reference to the accompanying drawings and examples. It should be understood that the system structure and business scenarios provided in the examples of the present application are mainly to illustrate the possible implementation methods of the technical solution of the present application and should not be interpreted as the only limitation on the technical solution of the present application. It is known to those of ordinary skill in the art that with the evolution of the system structure and the emergence of new business scenarios, the technical solution provided by the present application is also applicable to similar technical problems.

[0054] It should be understood that the embodiments of the present application provide a corneal anterior chamber inspection device and method, etc. Since the principles of these technical solutions to solve the problems are the same or similar, some repetitions may not be repeated in the following specific embodiments, but it should be considered that these specific embodiments have been referenced to each other and can be combined with each other.

[0055] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of this application. In the event of any inconsistency, the meaning described in this specification or the meaning derived from the contents recorded in this specification shall prevail. In addition, the terms used herein are only for the purpose of describing the embodiments of the present application and are not intended to limit the present application. In order to accurately describe the technical content in this application and to accurately understand the present invention, the following explanations or definitions are given to the terms used in this specification before describing the specific embodiments:

[0056] Blood-aqueous barrier (BAB): A physiological barrier in the eye, which is composed of vascular endothelial cells and ciliary non-pigmented epithelial cells in the ciliary body of the eyeball. Its main function is to maintain the stability of the contents and osmotic pressure of the intraocular fluid (i.e., aqueous humor), and prevent medium and large molecular blood components and other substances from entering the aqueous humor at will, so as to maintain the stability of the intraocular environment and normal vision. Pathological processes in the eye or the whole body will destroy its barrier function to varying degrees.

[0057] like Figure 1 As shown in FIG. 1 , it is a schematic diagram of the existing anterior chamber detection, in which the light source and the observation device are set at a certain angle to facilitate the observation of anterior chamber flare. In order to better observe the anterior chamber flare, the higher the incident light intensity, the better. However, in this scheme, the incident light has the risk of directly passing through the dilated pupil into the vitreous body and the fundus, so the incident light intensity is greatly limited. In addition, since the slit lamp is observed with the naked eye, there is no way to quantitatively detect the anterior chamber flare or suspended matter.

[0058] Please refer to Figure 2 , Figure 2 : is a schematic diagram of the structure of the eye detection device provided in the embodiment of the present application. It includes:

[0059] The system light source module 2 is used to emit light; the system light source module 2 can adopt a variety of light source modules including a comprehensive illumination system, a white light illumination system, a laser illumination system, etc.

[0060] The anterior chamber keratometer 4 is provided with an incident surface 41, a first reflecting surface 42 and a recessed portion 43 for fitting the eyeball, wherein the first reflecting surface 42 is arranged on one side of the recessed portion 43; the anterior chamber keratometer 4 receives the light emitted by the system light source module 2 through the incident surface 41, and reflects the light to the recessed portion 43 through the first reflecting surface 42, so that the light passes through the anterior chamber of the eyeball located at the recessed portion 43; the first light collection module 5 is arranged toward the recessed portion 43.

[0061] The incident light emitted by the system light source module 2 reaches the first reflection surface 42 through the incident surface 41. After the first reflection surface 42 reflects the incident light, it enters the anterior chamber from the cornea side of the eye through the recess 43. The light scattered from the eye in the anterior chamber is collected by the first light collection module 5.

[0062] In some embodiments, the anterior chamber keratoscope 4 is further provided with a second reflecting surface 44, which is provided on the other side of the concave portion 43 relative to the first reflecting surface 42; the light passing through the anterior chamber of the eyeball is reflected by the second reflecting surface 44, and the reflected light is emitted through the incident surface 41 of the anterior chamber keratoscope 4; a second light collection module 6 is provided in the direction in which the light is emitted from the incident surface 41. The light passing through the anterior chamber and reaching the second reflecting surface 44 is reflected by the second reflecting surface 44, emitted from the anterior chamber keratoscope 4 from the incident surface 41, and collected by the second light collection module 6.

[0063] The first light collection module 5 and the second light collection module 6 may include photoelectric detection components such as a camera, a photomultiplier tube / photodiode or other photosensitive elements. The camera can be used to collect static or dynamic image information of eye position, cornea and anterior chamber in real time, and the photomultiplier tube or photodiode can collect light energy information of cornea and anterior chamber in real time.

[0064] Please refer to Fig.11 In some embodiments, the anterior chamber keratoscope 4 is further provided with a light-stopping element 45, which is provided on the other side of the recess 43 relative to the first reflecting surface 42; the light passing through the anterior chamber of the eyeball is absorbed by the light-stopping element 45. The light passing through the anterior chamber is absorbed by the light-stopping element 45, so as to eliminate the influence of the light passing through the anterior chamber on the data collected by the first light collection module 5.

[0065] In some embodiments, the eye detection device is provided with a pressure sensor for sensing the force on the anterior chamber keratometer 4; a second micro-motion platform 3, on which the anterior chamber keratometer 4, the first light collection module 5 and / or the second light collection module 6 are arranged; a second driving device, for driving and adjusting the second micro-motion platform for multi-dimensional adjustment by automatic, manual or other means according to the force conditions, the examiner's (feedback) and the relative positional relationship between the eye detection device and the subject's eye.

[0066] In some embodiments, a first micro-motion platform 1 is provided with a system light source module 2 and a second micro-motion platform 3; a first driving device is used to drive and adjust the first micro-motion platform 1 for multi-dimensional adjustment by automatic, manual or other means according to the force conditions, the examiner's (feedback) and the relative positional relationship between the eye detection device and the subject's eye, and the adjustment range is greater than the adjustment range of the second micro-motion platform 3.

[0067] The pressure sensor can monitor the pressure and changes of the first micro-motion platform 1, the second micro-motion platform 3 and the anterior chamber keratoscope 4, and transmit the monitoring results to the host computer, controller or computer and other equipment in real time. Based on the above real-time measurement results, the computer and other equipment adjust the first driving device and / or the second driving device to drive the first micro-motion platform 1 and / or the second micro-motion platform 3 to perform multi-dimensional adjustment, so that the second micro-motion platform 3 and the anterior chamber keratoscope 4 have a feedback mechanism, which can automatically adjust the position according to the pressure threshold, and can also be fed back to the examiner through the human-computer interaction module, which can ensure the safety of the subject and improve the detection accuracy and reliability of the device.

[0068] In some embodiments, the pressure sensor can be replaced by a strain sensor, etc., which can convert non-electrical physical quantities such as displacement, pressure, acceleration, torque, etc. into electrical physical quantities, and can measure force, pressure, weight, displacement, acceleration and torque of each micro-motion platform and anterior chamber keratoscope, thereby providing more effective feedback and making more precise adjustments to each micro-motion platform and anterior chamber keratoscope.

[0069] In some embodiments, the third driving device is used to drive the system light source module 2 to perform multi-dimensional adjustment, and / or drive the system light source module 2 to rotate and adjust (adjust) at a certain angle in space.

[0070] In the present application, each driving device can perform multi-dimensional (multi-axis) adjustment, including adjustment in the X, Y, and Z axis directions, and five-dimensional adjustment of rotation in planes parallel and perpendicular to the first micro-motion platform 1. For example, by adjusting the third driving device in multiple dimensions, the angle of the incident light emitted by the system light source module 2 can be adjusted.

[0071] In a preferred embodiment of the present application, the incident light emitted by the system light source module 2 enters the anterior chamber of the eyeball in a light path approximately perpendicular to the eye axis after being reflected by the first reflective surface 42. In addition, since the light emitted by the system light source module 2 can be presented as an optical section, based on the above-mentioned multi-dimensional adjustment method, it can be adjusted to a better incident angle to obtain a better detection effect.

[0072] In addition, each driving device and each micro-motion platform in the present application can be provided with a locking structure to limit the range of movement and adjustment of each driving device and each micro-motion platform, thereby improving the safety of the eye detection device.

[0073] Finally, the data acquired by the first light collection module 5 and the second light collection module 6 are analyzed, calculated, stored, outputted, etc. to achieve eye detection.

[0074] The eye detection device provided in the embodiment of the present application enables the light source to be incident and scan the cornea and anterior chamber in a safe manner, avoiding the risk of the incident light directly passing through the pupil into the vitreous body and damaging the fundus structure and tissue. At the same time, using a specific light source, a detector system and a software reconstruction and recognition algorithm, the distribution and properties of corneal stroma and endothelial defects such as corneal opacity can be detected, and the size, optical characteristics, chemical composition, spectral characteristics, movement and other characteristics of suspended matter in the anterior chamber of the eye can be objectively quantified, and the distribution and content of certain specific substances in the anterior chamber can also be measured. In addition, by obtaining the scattered light in the anterior chamber by the first light collection module 5 and the outgoing light passing through the anterior chamber by the second light collection module 6, the particle size and distribution of the disease marker can be further analyzed, which broadens the detection range and content of the disease marker, thereby providing more diagnostic basis for eye detection.

[0075] The following is a further introduction to the method provided by the present application in conjunction with a specific implementation method. Figure 2 The eye detection device provided in this embodiment includes a first micro-motion platform 1, a system light source module 2, a second micro-motion platform 3, anterior chamber keratoscope 4, a first light collection module 5 and a second light collection module 6. The system light source module 2 and the second micro-motion platform 3 are installed on the first micro-motion platform 1, and the anterior chamber keratoscope 4, the first light collection module 5 and the second light collection module 6 are installed on the first micro-motion platform 1. The system light source module 2 and the second micro-motion platform 3 can be installed on the first micro-motion platform 1 through a driving device. By adjusting the driving device, the system light source module 2 and the second micro-motion platform 3 can be adjusted in multiple dimensions. Among them, in this embodiment, the X axis is defined as an axis parallel to the paper surface and in the left and right directions, the Y axis is defined as an axis parallel to the paper surface and in the up and down directions, and the Z axis is an axis perpendicular to the paper surface. In this embodiment, the adjustable mechanism including each driving device can perform multi-dimensional adjustments such as five-dimensional adjustments. For example, five-dimensional adjustments can include adjustments of the X, Y, and Z axes, and rotation in planes parallel to and perpendicular to the first micro-motion platform 1.

[0076] The first micro-motion platform 1 is also the platform of the whole machine of the eye detection device, which can be fully automatically controlled by a computer or other equipment, or can be manually or semi-automatically controlled in combination with manual control. The first micro-motion platform 1 can be manually or electrically adjusted in the X, Y, and Z axes, and the adjustment range is within 100 cm, and its accuracy is higher than ±10 mm. In addition, a mobile limiter can be set in the X-axis direction to ensure a safe distance between the device and the eye to be inspected. The first micro-motion platform 1 carries the system light source module 2 and the second micro-motion platform 3. The system light source module 2 and the second micro-motion platform 3 can be installed on the first micro-motion platform 1 respectively through the third driving device and the second driving device. By adjusting the driving device, the three-dimensional X, Y, and Z axis positions of the system light source module 2 and the second micro-motion platform 3 can be adjusted. A staring light 9 can also be set on the first micro-motion platform 1 to assist the examiner in fixing the eye position of the examinee for inspection. The light intensity, focus state, and color wavelength of the staring light 9 can be adjusted within a certain range to adapt to different environments and inspection requirements. The staring light 9 can be manually or automatically controlled by operation. Before the anterior chamber keratoscope 4 contacts the eye to be tested, the gaze lamp can provide a stable and accurate gaze position for the subject through the non-tested eye, so as to facilitate fixing the position of the eye to be tested. The gaze lamp light source adopts LED, which can flash or emit light continuously, and is fixed at the end of a mechanical arm whose position can be freely adjusted and fixed as needed, and the mechanical arm is connected and fixed to the first micro-motion platform 1.

[0077] The third driving device installed at the connection part between the system light source module 2 and the first fine-motion platform 1 can also be provided with a rotating part. By adjusting the rotating part, the system light source module 2 can rotate in a plane parallel or perpendicular to the first fine-motion platform 1, thereby adjusting the angle of the incident light emitted by the system light source module 2.

[0078] The system light source module 2 can have three optional settings, including Figure 3 The integrated irradiation system shown in Figure 4 The white light illumination system shown and Figure 5 The laser irradiation system shown in the figure includes a white light source or LED light source 2a, a cylindrical lens 2b, an electrically controlled variable slit aperture 1 2c, a filter group and a filter group control component 1 2d, a linear laser 2e, a switchable semi-mirror 2f, a light source detector 2g, a semi-reflective mirror 2h, an optical fiber system 1 2k, an optical fiber system 2 2l, an electrically controlled variable slit aperture 2 2m, a lens group and a control component 2n.

[0079] In each complete detection process, only one of the three light sources is selected for use. For example, the integrated light source system includes both a laser light source and a white light source (or LED light source). The two light sources can be switched with each other through computer-controlled electrically controlled variable slit aperture 12c and electrically controlled variable slit aperture 22m to ensure that they do not interfere with each other. The white light source system can be connected separately to a white light source that can excite fluorescence, such as a halogen lamp, mercury lamp, and xenon arc lamp. The light source can also be an LED lamp with a specific wavelength. The laser irradiation system can use laser as the light source alone. The laser light source can be introduced into the irradiation system through optical fiber, or it can be integrated according to the type of laser used without optical fiber connection. The types and wavelengths of the laser light sources can include the following types and ranges:

[0080] Laser Type Wavelength range (nM) Argon ion laser 270-530 Krypton ion laser 330-800 Helium-cadmium laser 320-640 Helium-Ne laser 540-633 Solid-state laser 355-533 Semiconductor laser / diode laser 300-2100

[0081] The second micro-motion platform 3 can perform multi-dimensional precise position adjustment, and automatically or manually align and adapt the relative position of the anterior chamber keratoscope 4 and the eyeball. Its adjustment range is not less than 10mm on the X, Y, and Z axes, with an accuracy higher than ±0.1mm and a response time faster than 1 second. And at the junction of its edge and the first micro-motion platform 1, a first pressure sensor 7 is provided, which can detect pressure and its changes, and transmit the measurement results to the computer in real time, with a measurement frequency faster than 1Hz and a sensitivity higher than 80mN.

[0082] The second micro-motion platform 3 carries the anterior chamber keratoscope 4, the first light collection module 5 and the second light collection module 6. In addition, based on the above-mentioned change in the angle of the incident light, the second micro-motion platform 3 can also be manually controlled or automatically controlled by a computer to adjust the positions of the first light collection module 5 and the second light collection module 6 to adapt to the angle of the incident light and collect the light emitted from the anterior chamber.

[0083] The anterior chamber keratoscope 4 is provided with an incident surface 41, a first reflecting surface 42, a concave portion 43 (or corneal contact surface) for fitting the eyeball, and a second reflecting surface 44, wherein the first reflecting surface 42 and the second reflecting surface 44 are provided on both sides of the concave portion 43; the incident light emitted by the system light source module 2 reaches the first reflecting surface 42 via the incident surface 41, and the first reflecting surface 42 reflects the incident light and enters the anterior chamber from the cornea side of the eyeball through the concave portion, and the light scattered out of the eyeball in the anterior chamber is collected by the first light collection module 5; the outgoing light passing through the cornea of ​​the eyeball and reaching the second reflecting surface 44 is reflected by the second reflecting surface 44 and collected by the second light collection module 6. In some embodiments, the incident light emitted by the system light source module 2 enters the anterior chamber of the eyeball in a light path approximately perpendicular to the eye axis after being reflected by the first reflecting surface 42. At this time, when the anterior chamber keratoscope 4 is provided with the first reflecting surface and the second reflecting surface, it can be called a dual-channel.

[0084] The anterior chamber keratoscope 4 is made of a transparent material with optical properties. The anterior chamber keratoscope 4 can transmit the illumination light, light signals, etc. to the corresponding mechanism. The interior thereof can realize the functions of light transmission, reflection, refraction and scattering as required. The incident angle range between the incident surface 41 and the incident light main light can be 70-120 degrees. The first reflection surface 42 and the second reflection surface 44 realize the refraction of the incident and outgoing light through total internal reflection or coating. Figure 6 FIG. 4 is a schematic diagram of the coupling between the anterior chamber keratometer and the anterior chamber provided in this embodiment. The anterior chamber keratometer 4 can be made of a material with a refractive index close to that of the cornea, so that light can be optically coupled with the cornea of ​​the eyeball through the concave portion. Figure 7 The anterior chamber keratometer structure schematic diagram (Z-axis projection) shown in the figure shows that the anterior chamber keratometer 4 can be 10-50 mm long, 2-30 mm wide, and 0.1 to 20 mm thick. The edges are chamfered to protect the cornea, sclera and periocular tissues, and the reflection surface angle is 30 to 60 degrees.

[0085] A second pressure sensor 8 is provided at the junction of the edge of the anterior chamber keratoscope 4 and the second micro-motion platform 3, which can detect the pressure and its change in the X, Y, and Z axes of the anterior chamber keratoscope, and transmit the measurement results to a computer or other equipment in real time. Based on the above-mentioned first pressure sensor 7 and second pressure sensor 8, the second micro-motion platform 3 and the anterior chamber keratoscope 4 have a feedback mechanism, which can automatically adjust the position according to the pressure threshold and feedback to the examiner through the human-computer interaction module, and the reaction speed is faster than 1 second.

[0086] The first light collection module 5 may include a spectroscope 51, a visible endoscope 52, a lens 1 53, a filter group and a filter group control component 2 54, a camera 1 55 and / or a photomultiplier tube / photodiode or other photosensitive element and other photoelectric detection components. The second light collection module 6 may include a lens 2 61, a filter group and a filter group control component 3 62, a camera 2 63 and / or a photomultiplier tube / photodiode or other photosensitive element and other photoelectric detection components. The structure of the lens 1 53 and the lens 2 61 is as shown in FIG. Figure 8 As shown in FIG. 1 , the corresponding lens can be selected by sliding. The structure of the filter group and the filter group control components 1, 2 and 3 is shown in FIG. Fig. 9 As shown, it includes a variety of filters, which can block light of specific wavelengths and allow light of its wavelength to pass through. The specific filter required by the operating system can be rotated and placed in the light path and play a role. The lens group and filter group control component can send its position and status information to the computer, and its response time is faster than 1 second. Lens types may include: spherical lens, cylindrical lens, lens group, etc.

[0087] The camera in the light collection module (the first light collection module 5 and the second light collection module 6) is used to collect static or dynamic images of the eye position, cornea and anterior chamber in real time. The wavelength response range of the camera system includes ultraviolet light, visible light and infrared light, the frame rate is not less than 20fps, and the resolution is not less than 480p. The photomultiplier tube or photodiode can collect the light energy information of the cornea and anterior chamber in real time, the frequency is not less than 50Hz, and the light signal of the target substance can be detected with a signal-to-noise ratio of not less than 3.

[0088] The light source of the visible endoscopic mark 52 is LED, which can flash or emit light continuously. It projects light into the eye through a spectroscope 51 to form a gaze point. The visible endoscopic mark can contain a lens to form a clear image of the gaze point. Before the anterior chamber keratoscope 4 contacts the eye to be tested, the visible endoscopic mark 52 and the gaze light 9 are used to assist the examiner and the subject to fix the position of the eye to be tested for inspection. After the anterior chamber keratoscope 4 contacts the cornea, the gaze light 9 is turned off and the visible endoscopic mark 52 is turned on to provide a stable and accurate gaze direction for the subject and the inspector. The light intensity, focus state, and color wavelength of the visible endoscopic mark 52 can be adjusted within a certain range to adapt to different environments and inspection requirements. The gaze light 9 and the visible endoscopic mark 52 can be manually or automatically controlled to switch through the operating system.

[0089] In addition, if Fig.10 As shown, the eye detection device provided in this embodiment may also include an automatic control and analysis device, which may be a control panel, a computer, a workstation, etc., for controlling the acquired information and status and also for analyzing, calculating, storing, and outputting data. The above modules and components are connected to the automatic control and analysis device by wired or wireless means, and the computing device may monitor and control the status of the above modules and components, and process the acquired data in real time. Processing of data and signals includes but is not limited to filtering, noise reduction, amplification, error correction, zeroing, calibration, encoding, etc. The components monitored in real time include but are not limited to: system light source module, filter group, lens group, anterior chamber keratoscope, first micro-motion platform, second micro-motion platform, camera, photomultiplier tube or photodiode, etc. The status of the system and components can also be monitored and controlled in real time. The acquired data include but are not limited to: the position data of the first micro-motion platform 1 (accuracy range is higher than ±0.1mm), the position data of the second micro-motion platform (accuracy is higher than ±0.1mm), the relative position data of the anterior chamber keratometer and the eye under examination (accuracy is higher than ±0.1mm), the pressure data of the anterior chamber keratometer (accuracy is higher than ±10μN), the pressure data of the second micro-motion platform (accuracy is higher than ±10μN), the position data of the filter group, the stability data of various light sources (output energy variation is less than 1%), etc.

[0090] The computing device may include an input module, an analysis module, a system status check and identification module, a system status control instruction set module, a human-computer interaction module, and a system control module. The input module is used to obtain the video, image, and photoelectric signal collected by the camera and the photosensitive element. The analysis module is used to perform quantitative and qualitative analysis and annotation on the collected image information, and can perform operations including but not limited to the following on the video, image, and photoelectric signal: storage, noise reduction, transformation, cutting, extraction, integration, 2D / 3D reconstruction, calculation, etc. At the same time, the module can be combined with prefabricated, pre-known or self-learning databases and patterns to calculate, mark, and identify the quality and quantity of the detection targets contained in the data and signals. The module can also automatically classify, identify, and process the video, image, and photoelectric signal through artificial intelligence or machine learning processes to achieve accurate detection and judgment of target molecules, cells, structures, clinical pathological changes, and clinical symptoms. The system status check and identification module is used to transmit information to the system status check and identification module based on the data processing and analysis results of the analysis module. The analysis module can also transmit information to the human-computer interaction module. The system automatically generates and outputs an inspection report, and can also provide real-time feedback to the operator through the human-computer interaction module. It can also store and output the processing results and extracted information. The data processing capability of the analysis module is not lower than the acquisition speed of video, image, and photoelectric signals. The system status control instruction set module can issue instructions to coordinate the work of various components of the system by integrating the system status information collected by the system's various sensing elements and the parameters set and fed back by the human-computer interaction module. The system control module can integrate system control instructions and output them to the corresponding drive (module, unit).

[0091] In some embodiments, Fig.11 As shown, a light-stopping element 45 is provided at the second reflective surface 44 of the anterior chamber keratoscope 4, which is used to absorb the outgoing light. At this time, the anterior chamber keratoscope 4 is a single channel. In a single-channel anterior chamber keratoscope, the light scattered in the anterior chamber emits the anterior chamber keratoscope and is collected by the first light collection module 5. The light passing through the anterior chamber and reaching the light-stopping element 45 will be absorbed, and the light will not reach the second light collection module 6, so as to avoid the light passing through the anterior chamber affecting the light collection of the first light collection module 5. Or in some other embodiments, when the anterior chamber keratoscope is provided with a light-stopping element, a structure without a second reflective surface can be adopted.

[0092] The eye detection device provided in the embodiment of the present application enables the light source to be incident on and scan the cornea and anterior chamber in a safe manner, avoiding the risk of the incident light directly passing through the dilated pupil into the vitreous body and damaging the fundus structure and tissue. At the same time, using a specific light source, detector system and software reconstruction and recognition algorithm, the physiological and pathological state and components of the cornea and the anterior chamber of the eye, structural changes, etc. can be detected.

[0093] like Fig.12 As shown, the eye detection method provided in the embodiment of the present application comprises the following steps:

[0094] S101: Adjust the first micro-motion platform.

[0095] The first micro-motion platform 1 can be manually or automatically adjusted in multiple axis directions within a range of 100 cm and with an accuracy of better than ±10 mm. The positive direction of the X-axis points to the subject or the eye being tested. In addition, a movement limiter is provided in the X-axis direction to ensure a safe distance between the device and the subject's eye being tested.

[0096] S102: Adjust the second micro-motion platform.

[0097] The second micro-motion platform 3 can perform precise position adjustment in multiple axis directions, and automatically or manually align and adapt the relative position of the anterior chamber keratometer 4 and the eyeball. Its adjustment range is not less than 10mm on the X, Y, and Z axes, the accuracy is higher than ±0.1mm, and the response time is faster than 1 second. The first micro-motion platform 1 is provided with a pressure sensor, which has a pressure sensing function, can detect pressure and its changes, and transmit the measurement results to a computer or controller in real time. Its measurement frequency is higher than 1Hz and its sensitivity is higher than 80mN. The pressure sensor and the first micro-motion platform 1 have a feedback mechanism. The first micro-motion platform 1 can automatically adjust the position according to the pressure threshold and feedback to the examiner through the human-computer interaction module, and the response speed is faster than 1 second.

[0098] S103: Adjust the relative position of the light source and the anterior chamber keratometer.

[0099] The system light source module 2 is installed on the first micro-motion platform 1 through a third driving device, and the third driving device can also be provided with a rotating part. By adjusting the multi-dimensional position of the third driving device and adjusting the angle of the rotating part, the incident light emitted by the system light source can enter and pass through the anterior chamber or cornea with an optical path approximately perpendicular to the eye axis (or other suitable angles), and the light scattered in the anterior chamber or cornea and the light passing through the anterior chamber can be collected by the first light collection module 5 and the second light collection module 6 respectively.

[0100] S104: The examiner controls the system's light source module to emit incident light to the anterior chamber corneal lens.

[0101] The incident light enters the incident surface 41 of the anterior chamber keratometer 4, and then is reflected by the first reflection surface 42 of the anterior chamber keratometer 4, and then enters and passes through the anterior chamber through the cornea in an optical path that is approximately perpendicular to the eye axis.

[0102] S105: Acquire light data of incident light passing through the anterior chamber.

[0103] The light scattered by the substances in the aqueous humor in the anterior chamber will be collected by the camera and other photosensitive elements of the first light collection module 5. In the dual-channel anterior chamber keratoscope 4, the light beam passing through the anterior chamber can be reflected by the second reflection surface 44 and then collected by the second light collection module 6; in the single-channel anterior chamber keratoscope, the light beam passing through the anterior chamber can be absorbed by the light-stopping element 45.

[0104] S106: Analyze the acquired light data.

[0105] The acquired light data can be used to analyze the optical and physical properties of the material in the anterior chamber based on different physical models and methods, including but not limited to dynamic light scattering.

[0106] In this embodiment, the light data collected by the first light collection module and the second light collection module are sent to a detector such as a computer for processing, and the results include frequency distribution or phase that changes with time, which represent the particle size of the suspended particles. The detector output signal consists of two parts: a constant that represents the average intensity of all collected light, and a component that changes with time that represents the dynamic light scattering effect.

[0107] According to the dynamic light scattering theory, the time-varying components can be analyzed to obtain the particle size distribution, and the multiple light scattering method can be used to evaluate the stability of the dispersed system. The signal captured by the detector can be analyzed and processed by correlation function analysis or frequency analysis.

[0108] Since the light intensity of the scattered light spot is related to the particle concentration and particle size in the sample, unstable information of the anterior chamber material can be obtained by analyzing the scattered light intensity, such as particle size changes, precipitation and floating, etc. This unstable information will reflect the development process of different diseases, such as inflammation level, treatment and recovery status, etc.

[0109] In some embodiments of the present application, the particles in the anterior chamber fluid can also be analyzed in combination with fluorescence technology. Fluorescence technology is a method for qualitative and quantitative analysis and identification of substances based on the position and intensity of the fluorescence spectrum of the substance. Fluorescence analysis has the advantages of high sensitivity, good selectivity, small sample dosage and simple operation. When detecting, some disease markers themselves do not emit fluorescence or the fluorescence is very weak, which requires converting the non-fluorescent substance into a substance that can emit fluorescence. One embodiment is to use a fluorescent dye, which can be combined with a non-fluorescent substance to form a complex, and then produce a fluorescent reaction for measurement. Fluorescence requires light irradiation of a specific wavelength, and fluorescence will also be generated at a corresponding specific wavelength, so the system needs a monochromatic light source as an excitation light and a wavelength screening unit in front of the detector. Generally, the monochromatic excitation light required for fluorescence is generated by a laser, and the wavelength of the narrow-band filter in front of the detector is used as a screening unit to perform specific detection of the target disease marker.

[0110] This embodiment can broaden the detection range and content of markers by combining fluorescence technology with dynamic light scattering methods and multiple light scattering. The particle size and distribution of these markers can be further analyzed through specific algorithms, thereby providing more diagnostic basis for eye detection.

[0111] In the above description, the numbers representing the steps, such as S101, S102, etc., do not necessarily mean that the steps will be executed in this manner. If permitted, the order of the steps can be interchanged, or the steps can be executed simultaneously.

[0112] The term "comprising" as used in the description and claims should not be interpreted as being limited to what is listed thereafter; it does not exclude other elements or steps. Therefore, it should be interpreted as specifying the presence of the features, integers, steps or components mentioned, but does not exclude the presence or addition of one or more other features, integers, steps or components and groups thereof. Therefore, the expression "a device comprising means A and B" should not be limited to a device consisting of components A and B only.

[0113] References to "one implementation" or "an embodiment" in this specification mean that a particular feature, structure, or characteristic described in conjunction with the embodiment is included in at least one embodiment of the present application. Therefore, the phrases "in one embodiment" or "in an embodiment" appearing in various places in this specification do not necessarily refer to the same embodiment, but may refer to the same embodiment. In addition, in one or more embodiments, the particular features, structures, or characteristics can be combined in any appropriate manner, as will be apparent to a person of ordinary skill in the art from this application.

[0114] Note that the above are only preferred embodiments of the present application and the technical principles used. Those skilled in the art will understand that the present application is not limited to the specific embodiments described herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present application. Therefore, although the present application is described in more detail through the above embodiments, the present application is not limited to the above embodiments, and may also include more other equivalent embodiments without departing from the concept of the present application, all of which belong to the scope of protection of the present application.

Claims

1. An eye detection device, characterized in that: include: A system light source module (2), used for emitting light; An anterior chamber keratoscope (4), the anterior chamber keratoscope (4) being provided with an incident surface (41), a first reflecting surface (42) and a recessed portion (43) for fitting an eyeball, the first reflecting surface (42) being provided on one side of the recessed portion (43); the anterior chamber keratoscope (4) receiving light emitted by the system light source module (2) through the incident surface (41), and reflecting the light through the first reflecting surface (42) to the recessed portion (43), so that the light enters the cornea or anterior chamber of the eyeball located at the recessed portion (43); The first light collection module (5) is arranged toward the recess (43).

2. The device according to claim 1, characterized in that: The anterior chamber keratoscope (4) is further provided with a second reflecting surface (44), and the second reflecting surface (44) is provided on the other side of the concave portion (43) relative to the first reflecting surface (42); the light passing through the anterior chamber of the eyeball is reflected by the second reflecting surface (44), and the reflected light is emitted through the incident surface (41) of the anterior chamber keratoscope (4); A second light collection module (6) is arranged facing the direction of the light emitted from the incident surface (41) of the anterior chamber corneal lens (4).

3. The device according to claim 1, characterized in that: The anterior chamber keratometer (4) is also provided with a light-stopping element (45), which is arranged on the other side of the recess (43) relative to the first reflecting surface (42); the light passing through the anterior chamber or cornea of ​​the eyeball is extinguished by the light-stopping element (45).

4. The device according to claim 2 or 3, characterized in that Also includes: a second micro-motion platform (3), on which the anterior chamber keratoscope (4), the first light collection module (5) and / or the second light collection module (6) are arranged; A first pressure sensor (7) for sensing the force applied to the second micro-motion platform (3); A second pressure sensor (8) for sensing the force applied to the anterior chamber keratoscope (4); The second driving device is used to drive the second micro-motion platform (3) to adjust according to the force condition.

5. The device according to claim 4, characterized in that Also includes: A first micro-motion platform (1), on which the system light source module (2) and the second micro-motion platform (3) are arranged; The first driving device is used to drive the first fine-motion platform (1) to adjust according to the force conditions, and the adjustment range is greater than the adjustment range of the second fine-motion platform (3).

6. The device according to claim 5, characterized in that Also includes: The third driving device is used to drive the system light source module (2) to perform adjustment.

7. An eye detection method based on the eye detection device according to any one of claims 1 to 6, characterized in that: include: emitting light through a system light source module (2); A first light collection module (5) is used to collect a first light and shadow of the anterior chamber of the eyeball located at a recess (43) of the anterior chamber corneal lens (4), wherein the first light and shadow includes the light and shadow when the light passes through the anterior chamber of the eyeball; The eye is detected based on the first light shadow.

8. The method according to claim 7, characterized in that Also includes: A second light collection module (6) is used to collect a second light shadow after the light is reflected by a second reflection surface (44) of the anterior chamber keratometer (4) and emitted from an incident surface (41) of the anterior chamber keratometer (4); The eye is also detected based on the second light shadow.

9. The method according to claim 7, characterized in that: Also includes: Adjusting the direction of light emitted by the system light source module (2) by at least one of the following methods; The first micro-motion platform (1) is driven by a first driving device to adjust, The second micro-motion platform (3) is driven by the second driving device to adjust, The system light source module (2) is driven by a third driving device for adjustment.

10. The method according to claim 9, characterized in that Also includes: The force condition of the second micro-motion platform (3) is sensed by the first pressure sensor (7), and the force condition of the anterior chamber keratoscope (4) is sensed by the second pressure sensor (8); The second fine motion platform (3) is driven to adjust according to the force conditions, and / or the first fine motion platform (1) is driven to adjust according to the force conditions, and the adjustment range is greater than the adjustment range of the second fine motion platform (3).

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