Storage mechanism and micro-fluidic chip

By designing a detachable storage mechanism, using long storage holes and uniform sized liquid sacs, the problem of insufficient versatility of traditional microfluidic chip storage mechanisms is solved, and more efficient reagent storage and more flexible adaptability are achieved. .

CN119429376APending Publication Date: 2025-02-14SHENZHEN YHLO BIOTECH
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Patent Information

Application Number
CN202411703353.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-26
Publication Date
2025-02-14

AI Technical Summary

Technical Problem

The storage mechanism of traditional microfluidic chips is insufficiently versatile, resulting in inflexible reagent storage and difficult to adapt to different types of chip bodies.

Method used

A detachable storage mechanism is designed, including a storage plate and a liquid sac, with multiple long-shaped storage holes being opened on the storage plate, and the liquid sac encapsulates reaction reagents and is contained in the storage hole. The storage board can be matched with different types of chip bodies, and the liquid sac size is the same, and is suitable for different types of chip bodies.

Benefits of technology

By optimizing the shape and layout of the storage holes, the volume utilization rate of the storage plate is improved, the volume and storage volume of the liquid sac are increased, so that the total storage amount of reaction reagents by the storage mechanism is greater than the amount required by various types of microfluidic chips. , improves the universality of storage institutions.

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Abstract

The invention relates to a storage mechanism and a micro-fluidic chip, the storage mechanism is used for being matched with a chip main body and comprises a storage plate, the storage plate is used for being detachably stacked on the chip main body, a plurality of storage holes are formed in the storage plate, the storage holes are arranged at intervals in the circumferential direction of the storage plate, and the cross section of each storage hole is in a long strip shape; and the liquid bag is used for packaging the reaction reagent, and the liquid bag is accommodated in the storage hole. The storage plate is provided with a plurality of storage holes, and the cross sections of the storage holes are long-strip-shaped but not circular, so that the storage amount of the storage mechanism for the reaction reagent can be increased, and the total storage amount of the storage mechanism for the reaction reagent is larger than the amount of the reaction reagent required by various types of micro-fluidic chips; therefore, the same storage mechanism can be matched with different types of micro-fluidic chips. The sizes of the liquid bags on the storage mechanism are consistent, so that the liquid bags of the same model can be suitable for different types of chip main bodies and micro-fluidic chips, and the universality of the storage mechanism is improved.
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Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to a storage mechanism and a microfluidic chip including the storage mechanism. Background Art

[0002] Microfluidic chips are microanalysis systems that integrate sample pretreatment, mixing, reaction, separation, and detection into one or more chips. They are increasingly used in disease detection, food safety, environmental testing, and drug screening. In the early days, microfluidic chips were manually added with reagents, which was complex and had large errors. In recent years, reagent pre-packaging technology has gradually been applied to microfluidic chips, that is, the packaged reagent storage mechanism is placed on the microfluidic chip. However, for traditional microfluidic chips, there is usually a defect that the reagent storage mechanism is not universal enough. Summary of the invention

[0003] A technical problem solved by the present application is how to improve the versatility of the storage mechanism.

[0004] On one hand, the present application provides a storage mechanism for matching with a chip body, the storage mechanism comprising:

[0005] A storage plate, the storage plate is used to be detachably stacked on the chip body, a plurality of storage holes are opened on the storage plate, the plurality of storage holes are arranged at intervals along the circumference of the storage plate, and the cross section of the storage hole is in the shape of a long strip; and

[0006] A liquid capsule is used to encapsulate a reaction reagent, and the liquid capsule is accommodated in the storage hole.

[0007] In one embodiment, the cross-section of the storage hole is trapezoidal, rectangular, elliptical or triangular.

[0008] In one embodiment, when the cross section of the storage hole is a trapezoid, the four corners of the trapezoid are rounded.

[0009] In one of the embodiments, when the cross-section of the storage hole is a trapezoid, the lower base of the trapezoid is closer to the outer edge of the storage plate than the upper base of the trapezoid.

[0010] In one embodiment, the storage plate is circular, and a through hole is formed on the storage plate. The center of the through hole and the storage plate coincide with each other, and the plurality of storage holes are arranged around the through hole.

[0011] In one of the embodiments, there is a spacing between the storage hole and the edge of the through hole, and between the storage hole and the outer edge of the storage plate, and the spacing ranges from 1 mm to 5 mm.

[0012] In one of the embodiments, the storage plate is further provided with an injection hole and a window hole, both of which penetrate the storage plate along the thickness direction of the storage plate, the injection hole is spaced between the storage hole and the through hole, and the window hole is spaced between the storage hole and the through hole.

[0013] In one of the embodiments, a positioning hole is provided on the outer edge of the storage board, and the positioning hole is used to cooperate with the chip body.

[0014] In one of the embodiments, it further includes a puncture member, which is disposed on the storage plate and used to puncture the liquid capsule; or, the liquid capsule includes a fixed-point blasting structure, which is located in the storage hole and can release the reaction reagent in the liquid capsule without a puncture member.

[0015] On the other hand, the present application provides a microfluidic chip, comprising a chip body and any one of the above-mentioned storage mechanisms, wherein the storage board is stacked on the chip body.

[0016] A technical effect of an embodiment of the present application is: in view of the fact that the storage hole is provided on the storage plate, the cross section of the storage hole is a long strip rather than a circle, so that the limited space of the storage plate is fully utilized, on the one hand, the total number of storage holes that can be set on the storage plate can be increased, and on the other hand, the volume of a single storage hole can be increased, thereby increasing the total volume formed by all the storage holes, that is, increasing the volume of all the liquid capsules, and then greatly increasing the amount of reaction reagents in the liquid capsules stored in all the storage holes, that is, increasing the storage capacity of the storage mechanism for reaction reagents, so that the total storage capacity of the storage mechanism for reaction reagents can be greater than the amount of reaction reagents required for various types of microfluidic chips, and in view of the fact that the storage plate can be detachably mounted to the chip body, the same storage plate can be mounted to different chip bodies to form different types of storage mechanisms. Since the size of the liquid capsules on the storage mechanism is consistent, the same type of liquid capsules can be used for different types of chip bodies and microfluidic chips, so that the storage mechanism formed by the same type of liquid capsules can be installed on different chip bodies, that is, different types of microfluidic chips can use the same type of liquid capsules, thereby improving the versatility of the storage mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] FIG1 is a schematic diagram of a partial planar structure of a microfluidic chip provided in an embodiment.

[0018] FIG. 2 is a schematic diagram of the planar structure of the storage mechanism in the microfluidic chip shown in FIG. 1 .

[0019] Reference numerals: microfluidic chip 10 , chip body 100 , storage mechanism 200 , storage plate 210 , storage hole 211 , through hole 212 , outer edge 213 , inner edge 214 , injection hole 215 , window hole 216 , positioning hole 217 , liquid capsule 220 . DETAILED DESCRIPTION

[0020] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0021] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0022] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0023] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0024] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0025] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only implementation method.

[0026] Referring to Figures 1 and 2, a microfluidic chip 10 provided in one embodiment of the present application includes a chip body 100 and a storage mechanism 200, the storage mechanism 200 includes a storage plate 210 and a liquid capsule 220, the liquid capsule 220 is arranged on the storage plate 210, the liquid capsule 220 can encapsulate a certain amount of liquid, the liquid can be a reaction reagent, the reaction reagent in the liquid capsule 220 can flow into the reaction chamber on the chip body 100 through the middle channel, so that the reaction reagent produces a reaction in the reaction chamber for detection.

[0027] Referring to FIG. 1 and FIG. 2 , in some embodiments, the storage board 210 is detachably stacked on the chip body 100, and the shape of the storage board 210 can be substantially the same as that of the chip body 100, and the cross-sectional dimension of the storage board 210 can be smaller than the cross-sectional dimension of the chip body 100. For example, when the shapes of the storage board 210 and the chip body 100 are both circular, the diameter of the storage board 210 can be smaller than the diameter of the chip body 100. The storage board 210 is provided with storage holes 211, and the number of the storage holes 211 is multiple, and the multiple storage holes 211 are arranged at intervals along the circumference of the storage board 210, and the cross-section of the storage hole 211 can be a long strip, for example, the cross-section of the storage hole 211 can be a trapezoid, a rectangle, an ellipse or a triangle. The liquid capsule 220 is contained in the storage hole 211. The liquid capsule 220 can be completely contained in the storage hole 211. The volume of the liquid capsule 220 can be roughly equivalent to the volume of the storage hole 211, that is, the larger the storage hole 211 is, the larger the storage hole 211 can be, and the larger the volume of the liquid capsule 220 can be. Obviously, the larger the volume of the liquid capsule 220 can hold more reaction reagents. Therefore, the larger the volume of a single storage hole 211 is, the greater the amount of reaction reagents that can be stored in the storage mechanism 200 will be. The liquid capsule 220 can be fixed on the storage plate 210 by gluing, hot pressing, ultrasonic welding or laser welding. When the liquid capsule 220 is fixed on the storage plate 210, the liquid capsule 220 will form a sealing effect on the storage hole 211. When the reaction reagent in the liquid capsule 220 is released, it can effectively ensure that the reaction reagent in the liquid capsule 220 is completely released in the storage hole 211, and avoid the reaction reagent released into the storage hole 211 from leaking from the storage hole 211. Of course, the liquid capsule 220 can also be connected to the storage plate 210 in an integrally formed manner. The liquid capsule 220 can be made of aluminum material or plastic material, and the storage plate 210 can also be made of aluminum material or plastic material. The maximum amount of reaction reagent stored in a single liquid capsule 220 can be 100 μL to 1000 μL, for example, the maximum amount of reaction reagent stored in a single liquid capsule 220 can be 100 μL, 200 μL, 800 μL or 1000 μL, etc.

[0028] The liquid capsule 220 may correspond to the storage hole 211 one by one, that is, the number of the liquid capsule 220 and the storage hole 211 may be equal, so that each storage hole 211 contains one liquid capsule 220. The storage mechanism 200 may also include a puncture member, which may be a needle-shaped structure. Before releasing the reaction reagent in the liquid capsule 220, a certain distance is maintained between the puncture member and the liquid capsule 220 to prevent the puncture member from puncturing the liquid capsule 220 and causing the reaction reagent in the liquid capsule 220 to be released in advance. The puncture member is arranged on the storage plate 210 and corresponds to the storage hole 211. When a pressing force is applied to the liquid capsule 220, or the liquid capsule 220 is subjected to the centrifugal force, the liquid capsule 220 is deformed and contacts the puncture member, and the liquid capsule 220 is punctured by the puncture member, so that the reaction reagent in the liquid capsule 220 flows into the storage hole 211, and flows from the storage hole 211 through the middle channel into the reaction chamber of the chip body 100. Of course, the liquid capsule 220 may include a fixed-point blasting structure, that is, the liquid capsule 220 itself has a fixed-point blasting structure. When pressing pressure is applied to the liquid capsule 220, or the liquid capsule 220 is under the action of centrifugal force, the fixed-point blasting structure of the liquid capsule 220 is damaged, which can also allow the reaction reagent in the liquid capsule 220 to flow into the storage hole 211, and flow from the storage hole 211 through the middle channel into the reaction chamber of the chip body 100.

[0029] In some embodiments, when the cross section of the storage hole 211 is a trapezoid, the lower bottom of the trapezoid is closer to the outer edge 213 of the storage plate 210 than the upper bottom of the trapezoid. In other words, the lower bottom of the trapezoid with a relatively long length is arranged close to the outer edge 213 of the storage plate 210, while the upper bottom of the trapezoid with a relatively short length is arranged farther away from the outer edge 213 of the storage plate 210. This structural arrangement allows a greater number of storage holes 211 to be arranged on the storage, so that the storage plate 210 can carry a greater number of liquid capsules 220, and ultimately the entire storage mechanism 200 can store a greater amount of reaction reagents. The storage plate 210 can be circular, and the height direction of the trapezoid can be the same as the radial direction of the storage plate 210, so that the storage holes 211 can reasonably utilize the space of the storage plate 210.

[0030] If the cross section of the storage hole 211 is circular, it is difficult for the circular storage hole 211 to effectively utilize the limited space of the storage plate 210, which results in a limited number of circular storage holes 211 and a limited volume of the circular storage holes 211. This results in a limited total volume formed by all the circular storage holes 211, and thus a limited amount of reaction reagents in the liquid capsule 220 stored by all the circular storage holes 211. In other words, the maximum amount of reaction reagents that can be released by the storage mechanism 200 is limited, that is, the storage capacity of the storage mechanism 200 for reaction reagents is limited. As for the storage mechanism 200 in the above embodiment, since the cross-section of the storage hole 211 is trapezoidal, the storage hole 211 can extend radially along the storage plate 210, so that the storage hole 211 can make full use of the limited space of the storage plate 210 in the radial direction. On the one hand, the total number of storage holes 211 that can be set on the storage plate 210 can be increased, and on the other hand, the volume of a single storage hole 211 can be increased, thereby increasing the total volume formed by all the trapezoidal storage holes 211, that is, increasing the volume of all the liquid capsules 220, and then greatly increasing the amount of reaction reagents in the liquid capsules 220 stored in all the trapezoidal storage holes 211. In other words, the maximum amount of reaction reagents that can be released by the storage mechanism 200 will be greatly increased, that is, the storage capacity of the storage mechanism 200 for reaction reagents will be increased.

[0031] Referring to FIG. 2 , in some embodiments, when the cross section of the storage hole 211 is a trapezoid, the four corners of the trapezoid are all rounded, so that on the one hand, the volume of a single trapezoidal storage hole 211 can be further increased, so that the storage hole 211 can accommodate a larger volume of the liquid capsule 220, and the maximum amount of the reaction reagent that can be released by the storage mechanism 200 will be greatly increased, that is, the storage capacity of the reaction reagent by the storage mechanism 200 is further increased. On the other hand, it can effectively avoid the existence of sharp edges and corners on the inner wall surface of the storage hole 211, that is, by setting the rounded corners to passivate the sharp edges and corners, it is avoided that the sharp edges and corners puncture the liquid capsule 220 and cause the reaction reagent in the liquid capsule 220 to be released prematurely, thereby improving the safety of the storage mechanism 200 during transportation.

[0032] In some embodiments, when the storage plate 210 is circular, a through hole 212 is further provided on the storage plate 210. The through hole 212 can penetrate the entire storage plate 210 along the thickness direction of the storage plate 210. The through hole 212 can be a circular hole. The center of the through hole 212 can coincide with the center of the storage plate 210. In this way, the storage hole 211 provided with the through hole 212 is roughly annular. Therefore, the storage plate 210 has an outer edge 213 and an inner edge 214. The inner edge 214 of the storage plate 210 can actually be understood as the inner wall surface of the through hole 212. By providing the through hole 212, the through hole 212 can be used to position the storage plate 210 during the installation process, thereby improving the installation accuracy and efficiency of the storage plate 210. In other embodiments, the shape of the storage plate 210 can also be a fan-shaped, semicircular or horseshoe-shaped shape.

[0033] Referring to FIG. 2 , in some embodiments, all storage holes 211 may be arranged around the through hole 212, and along the radial direction of the storage plate 210, the distances from each storage hole 211 to the through hole 212 may be equal, thereby making the storage plate 210 have a certain degree of symmetry, thereby reducing the difficulty of processing the storage plate 210, and ultimately reducing the manufacturing cost by improving the processing efficiency of the storage plate 210. There is a spacing between the storage hole 211 and the edge of the through hole 212, that is, there is a spacing between the storage hole 211 and the inner wall surface of the through hole 212, which can also be understood as a spacing between the storage hole 211 and the inner edge 214 of the storage plate 210, and the value range of the spacing may be 1 mm to 5 mm, for example, the specific value of the spacing may be 1 mm, 2 mm, 3 mm or 5 mm, etc. By the existence of this spacing, the storage hole 211 can have a reasonable safety distance. When the liquid capsule 220 is accommodated in the storage hole 211, the liquid capsule 220 is prevented from rupturing in the storage hole 211 and releasing the reaction reagent in advance. The structural strength of the hole wall of the storage hole 211 can also be improved to avoid cracks in the storage hole 211 due to the weak structural strength of the hole wall. Similarly, there is also a spacing between the storage hole 211 and the outer edge 213 of the storage plate 210. The value range of the spacing can be 1mm to 5mm. For example, the specific value of the spacing can be 1mm, 2mm, 3mm or 5mm. By the existence of this spacing, the storage hole 211 can have a reasonable safety distance. When the liquid capsule 220 is accommodated in the storage hole 211, the liquid capsule 220 is prevented from rupturing in the storage hole 211 and releasing the reaction reagent in advance. The structural strength of the hole wall of the storage hole 211 can also be improved to avoid cracks in the storage hole 211 due to the weak structural strength of the hole wall.

[0034] Referring to FIG. 2 , in some embodiments, the storage plate 210 is further provided with an injection hole 215 and a window hole 216. The injection hole 215 is a through hole, so that the injection hole 215 penetrates the storage plate 210 along the thickness direction of the storage plate 210, and the window hole 216 is also a through hole, so that the window hole 216 penetrates the storage plate 210 along the thickness direction of the storage plate 210. The injection hole 215 is arranged between the storage hole 211 and the through hole 212, and the window hole 216 is arranged between the storage hole 211 and the through hole 212. By providing the injection hole 215, a sample can be added to the chip body through the injection hole 215, so that the reaction reagent flowing from the liquid capsule 220 into the reaction chamber produces a chemical reaction with the sample for detection. By providing the window hole 216, the operating state in the microfluidic chip 10 can be observed by naked eyes through the window hole 216. By keeping a certain distance between the storage hole 211 and the injection hole 215, it is also possible to ensure that the hole wall of the storage hole 211 has sufficient structural strength, avoid cracks in the storage hole 211, and avoid the liquid capsule 220 from rupturing in the storage hole 211 and releasing the reaction reagent in advance. Similarly, by keeping a certain distance between the storage hole 211 and the window hole 216, it is also possible to ensure that the hole wall of the storage hole 211 has sufficient structural strength, avoid cracks in the storage hole 211, and avoid the liquid capsule 220 from rupturing in the storage hole 211 and releasing the reaction reagent in advance. The through hole 212 can be located between the injection hole 215 and the window hole 216, so that the limited space of the storage plate 210 can be fully utilized to reasonably arrange the injection hole 215 and the window hole 216.

[0035] If the microfluidic chip 10 adopts a mode in which the liquid capsule 220 is directly arranged on the chip body 100, that is, the storage hole 211 is directly opened on the chip body 100, so that the liquid capsule 220 is accommodated in the storage hole 211. In view of the different amounts of reaction reagents required by different microfluidic chips 10 during the detection process, the sizes of the storage holes 211 and the liquid capsule 220 on different microfluidic chips 10 will be inconsistent, that is, there are liquid capsules 220 of different sizes on different chip bodies 100. It can be understood that the same type of liquid capsule 220 can only be applied to a specific type of chip body 100, and the liquid capsule 220 of this type cannot be installed on other types of chip bodies 100, thereby reducing the versatility of the liquid capsule 220.

[0036] Referring to FIG. 1 and FIG. 2 , for the microfluidic chip 10 in the above embodiment, the storage hole 211 is provided on the storage plate 210 instead of being provided directly on the chip body 100. At the same time, the cross section of the storage hole 211 is a strip rather than a circle, so that the limited space of the storage plate 210 is fully utilized. On the one hand, the total number of storage holes 211 that can be provided on the storage plate 210 can be increased, and on the other hand, the volume of a single storage hole 211 can be increased, thereby increasing the total volume formed by all storage holes 211, that is, increasing the volume of all liquid capsules 220, and then greatly increasing the amount of reaction reagents in the liquid capsules 220 stored by all storage holes 211, that is, increasing the storage capacity of the storage mechanism 200 for reaction reagents. The total storage capacity of the storage mechanism 200 for reaction reagents can be 1.1 to 1.5 times the amount of reaction reagents required for each type of microfluidic chip 10, that is, the total storage capacity of the storage mechanism 200 for reaction reagents is greater than the amount of reaction reagents required for each type of microfluidic chip 10. Since the storage board 210 is detachably connected to the chip body 100, the storage mechanism 200 can be installed on different types of chip bodies 100 to form different types of microfluidic chips 10. Since the sizes of the liquid capsules 220 on the storage mechanism 200 are all the same, the same type of liquid capsules 220 can be used for different types of chip bodies 100 and microfluidic chips 10, so that the storage mechanism 200 formed by the same type of liquid capsules 220 can be installed on different chip bodies 100, that is, different types of microfluidic chips 10 can use the same type of liquid capsules 220, thereby improving the versatility of the storage mechanism 200.

[0037] In view of the fact that the total storage capacity of the storage mechanism 200 for reaction reagents is greater than the amount of reaction reagents required by each type of microfluidic chip 10, there is no need to release the reaction reagents in all the liquid capsules 220 on the storage mechanism 200. It is only necessary to release the reaction reagents in some of the liquid capsules 220 on the storage plate 210 according to specific needs. When the amount of reaction reagents required by different microfluidic chips 10 is different, the reaction reagents in different numbers of liquid capsules 220 on the storage plate 210 can be released.

[0038] In some embodiments, a positioning hole 217 is provided on the outer edge 213 of the storage board 210. The positioning hole 217 is used to cooperate with the chip body 100. By providing the positioning hole 217, it can be ensured that the storage board 210 can only be superimposed on the chip body 100 in a certain installation orientation. When the installation position of the storage board 210 changes, the positioning hole 217 of the storage board 210 will interfere with the chip body 100, resulting in the inability to install the storage board 210, thereby playing a warning effect of installation errors. Therefore, by providing the positioning hole 217, the storage mechanism 200 can play a fool-proof role during the installation process, thereby ensuring that the storage mechanism 200 is always fixed on the chip body 100 in the correct installation position, and ultimately improving the installation accuracy of the storage mechanism 200.

[0039] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0040] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A storage mechanism, used to match a chip body, characterized in that: The storage mechanism comprises: A storage plate, the storage plate is used to be detachably stacked on the chip body, a plurality of storage holes are opened on the storage plate, the plurality of storage holes are arranged at intervals along the circumference of the storage plate, and the cross section of the storage hole is in the shape of a long strip; and A liquid capsule is used to encapsulate a reaction reagent, and the liquid capsule is accommodated in the storage hole.

2. The storage mechanism according to claim 1, characterized in that: The cross section of the storage hole is trapezoidal, rectangular, elliptical or triangular.

3. The storage mechanism according to claim 2, characterized in that: When the cross section of the storage hole is a trapezoid, four corners of the trapezoid are rounded.

4. The storage mechanism according to claim 3, characterized in that: When the cross section of the storage hole is a trapezoid, the lower base of the trapezoid is closer to the outer edge of the storage plate than the upper base of the trapezoid.

5. The storage mechanism according to claim 1, characterized in that: The storage plate is circular, and a through hole is formed on the storage plate. The center of the through hole and the storage plate coincide with each other, and the plurality of storage holes are arranged around the through hole.

6. The storage mechanism according to claim 5, characterized in that: There is a spacing between the storage hole and the edge of the through hole, and between the storage hole and the outer edge of the storage plate, and the spacing ranges from 1 mm to 5 mm.

7. The storage mechanism according to claim 5, characterized in that: The storage plate is also provided with an injection hole and a window hole, both of which penetrate the storage plate along the thickness direction of the storage plate, the injection hole is arranged between the storage hole and the through hole, and the window hole is arranged between the storage hole and the through hole.

8. The storage mechanism according to claim 1, characterized in that: A positioning hole is provided on the outer edge of the storage board, and the positioning hole is used to cooperate with the chip body.

9. The storage mechanism according to claim 1, characterized in that: It also includes a puncture piece, which is arranged on the storage plate and used to puncture the liquid capsule; or the liquid capsule includes a fixed-point blasting structure, which is located in the storage hole and can release the reaction reagent in the liquid capsule without a puncture piece.

10. A microfluidic chip, characterized in that: The invention comprises a chip body and the storage mechanism according to any one of claims 1 to 9, wherein the storage board is stacked on the chip body.

Citation Information

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