Phenylthiazole derivatives, compositions and uses thereof
By designing phenylthiazole derivatives as FLT3-ITD inhibitors, the problem of effectively inhibiting cell proliferation disorders caused by FLT3-ITD mutations in existing technologies has been solved, providing a highly effective and low-side-effect treatment option, especially a novel therapeutic compound for acute myeloid leukemia.
CN119431355BActive Publication Date: 2026-06-09XUZHOU MEDICAL UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- XUZHOU MEDICAL UNIVERSITY
- Filing Date
- 2024-11-06
- Publication Date
- 2026-06-09
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Figure CN119431355B_ABST
Abstract
The application discloses a kind of phenylthiazole derivatives, composition and application thereof, the derivative is the compound with as described in structural general formula (I) or its pharmaceutically acceptable salt;The composition includes phenylthiazole derivative or its pharmaceutically acceptable salt, and one or more pharmaceutically acceptable carriers.The application also provides the application of phenylthiazole derivative or its pharmaceutically acceptable salt in preparing drug for treating the proliferative disease of patient.The application provides a new kind of inhibitor for FLT3-ITD mutation, and the inhibitory activity of FIT3-ITD is equivalent to Quizartinib, and MV4-11 cell has good inhibitory effect, and provides a new type of lead compound for the treatment and prevention of disease.
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