Ruthenium polypyridyl complexes with polyhedral ring and quaternary ammonium salt structures, methods of making and using the same

Abstract

The application discloses a ruthenium polypyridyl complex with polybasic cyclic and quaternary ammonium salt structures and a preparation method and application thereof. The ruthenium polypyridyl complex with polybasic cyclic and quaternary ammonium salt structures comprises metal ions, is coordinated with bipyridine with different substituents and has a positive charge, can be combined with negative ions on the surface of a bacterial cell membrane, destroys the bacterial cell membrane, thereby inhibits the growth of bacteria and finally kills the bacteria. Staphylococcus aureus can produce a multi-layer biofilm embedded in a cell envelope and a slime layer, and expresses proteins with heterogeneity in the whole process, hinders the penetration of drugs and increases the chance of host immune escape, helps the bacteria resist the environment and causes persistent infection, so that inhibiting the formation of the biofilm is a key point of antibacterial medical technology research. The carbon chain structure, polybasic heterocyclic structure and quaternary ammonium salt structure are introduced into the ruthenium polypyridyl ligand, the ability of destroying the bacterial cell membrane is enhanced through the action of different groups, and the biological activity is improved.

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