High spatial and spectral resolution energy-spectral CT and optical dual-mode imaging systems and methods

By combining multi-band fluorescence data and multi-level X-ray projection data acquisition with tensor dictionary learning and photon transport forward model, the problem of insufficient resolution in CT and optical dual-mode imaging was solved, realizing high spatial and spectral resolution energy spectral CT and optical dual-mode imaging, and improving the spatial resolution and optical reconstruction capability of the imaged object.

CN119454068BActive Publication Date: 2026-05-26FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Filing Date
2024-11-11
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

In existing dual-mode imaging technologies of CT and optics, CT has weak energy and spectral resolution, resulting in low soft tissue contrast in imaging. Furthermore, optical and CT image reconstructions are independent of each other, and spatial resolution needs to be improved.

Method used

By employing multi-band fluorescence data and fluorescence image acquisition, multi-level X-ray projection data acquisition, and combining 3D reconstruction based on tensor dictionary learning and photon transport forward model, data is acquired through a hyperspectral camera and X-ray energy spectrum detector. Wavelet transform is used for image fusion to achieve high spatial and spectral resolution energy spectrum CT and optical dual-mode imaging.

Benefits of technology

It improves the spatial and spectral resolution of dual-mode fusion images, enables precise decomposition of various structures or components of the imaged object, and enhances the spatial resolution and morphological resolution of optical imaging.

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Abstract

This invention discloses a high spatial and spectral resolution dual-mode imaging system and method for energy-spectral CT and optical imaging. The system uses an X-ray energy-spectral detector to acquire multi-level X-ray projection data; a hyperspectral camera is used to acquire multi-band fluorescence data and fluorescence images. The method includes correcting the X-ray projection at each energy level, performing three-dimensional reconstruction on the corrected multi-level projection data, volume rendering of the reconstructed three-dimensional data to obtain the three-dimensional contour of the object, mapping the fluorescence data onto the three-dimensional contour, and for each spectral band, constructing and reconstructing an accurate photon transport forward model based on the accurate material decomposition results obtained from the multi-level CT reconstruction, referencing the scattering and absorption coefficients of different materials, and based on the third-order simplified spherical harmonic equation, performing three-dimensional registration and image fusion of the dual-mode images to obtain a dual-mode fused image. The dual-mode fused image obtained by this invention has high spatial and spectral resolution.
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