Composition for bidirectionally regulating scalp micro-ecological balance and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a composition for bidirectionally adjusting scalp micro-ecological balance and application thereof, and the composition for bidirectionally adjusting scalp micro-ecological balance comprises L-pyrrolidone carboxylic acid zinc salt, maltooligosacharide, hinokiol and water. The composition capable of bidirectionally adjusting scalp micro-ecological balance is applied to a scalp care product, and the scalp care product is one of shampoo, shampoo, hair conditioner, hair mask, scalp cleaning agent and scalp essence. The shampoo can be applied to scalp hair care products, and the scalp hair care products are shampoo well known by people in the technical field. The activity of harmful bacteria easily causing scalp inflammation, namely staphylococcus aureus and malassezia, is inhibited; meanwhile, the activity of beneficial bacteria, namely staphylococcus epidermidis, capable of maintaining the scalp barrier function can be promoted, the effect of preventing scalp inflammation is never achieved, the activity of harmful bacteria can be effectively inhibited, meanwhile, the activity of the beneficial bacteria can be improved, and scalp micro-ecological balance can be bidirectionally adjusted.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, in particular to a composition for bidirectionally regulating the microecological balance of a scalp and an application thereof. Background Art

[0002] The surface of healthy skin has a microbial flora, just like the intestinal system. The scalp is part of the skin and is covered by hair. The sebum and sweat secreted by the scalp are more easily used by microorganisms, becoming a hotbed and safe haven for their reproduction. Common bacteria on the scalp include Staphylococcus aureus, a bacterial species, and Malassezia, a fungus. Among the Staphylococci, there is Staphylococcus epidermidis, which can decompose triglycerides in sebum into fatty acids and glycerol. The fatty acids produced keep the scalp slightly acidic, which can inhibit the production of Staphylococcus aureus that causes inflammatory reactions and protect the scalp. Glycerol has a moisturizing effect on the scalp and can maintain the barrier function of the scalp. Therefore, Staphylococcus epidermidis is considered to be a beneficial bacteria in the scalp. Staphylococcus aureus is a harmful bacteria. When the skin is injured or alkaline, Staphylococcus aureus will multiply in large numbers, thereby destroying the acidity and alkalinity of the skin and causing a sharp drop in the number of Staphylococcus epidermidis, which can cause inflammatory reactions, abscesses and other problems. Another fungus in the scalp, Malassezia, is considered to be the culprit of dandruff problems. It breaks down triglycerides in sebum into saturated fatty acids and unsaturated fatty acids. Among them, unsaturated fatty acids are irritating to the scalp, directly causing redness, itching, inflammation and excessive dandruff. In addition, the sebaceous glands in the scalp are the most distributed in the whole body, and the distribution of sweat glands is second only to the hands and feet. Therefore, the sebum and sweat secreted on the scalp are more than other parts, and naturally it is more likely to cause microbial flora imbalance than other parts. Micro-changes in the body in various aspects such as exercise, ultraviolet radiation, emotions, and stress may cause local microecological imbalance at any time. To maintain the balance of scalp microbial ecology, simply increasing beneficial bacteria or decreasing harmful bacteria cannot effectively maintain the balance effect in the long term. For example, simply adding ingredients that are effective for beneficial bacteria, while nourishing probiotics, it is also easy to help the reproduction of harmful bacteria, causing malignant bacteria to gradually multiply in large numbers. In fact, harmful bacteria are more difficult to control, because harmful bacteria are divided into Malassezia, a fungus, and Staphylococcus aureus, a bacteria. If only fungicides are used, Malassezia can be controlled, but Staphylococcus aureus cannot be well suppressed. If antibacterial and antifungal fungicides are used at the same time, the reproduction of Staphylococcus epidermidis, which is also a beneficial bacterium, is suppressed.

[0003] Therefore, finding a composition that can effectively inhibit the activity of harmful bacteria and enhance the activity of beneficial bacteria is the technical research and development focus of the present invention. At the same time, the composition can be stably applied to the formula of hair care products without precipitation or suspension. Summary of the invention

[0004] The purpose of the present invention is to provide a composition for bidirectionally regulating the scalp microecological balance and its application, so as to solve the problems raised in the above background technology.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a composition for bidirectionally regulating the microecological balance of the scalp, the components of which include: L-pyrrolidonecarboxylic acid zinc salt, maltooligosaccharide, cypress phenol and water.

[0006] Preferably, the composition for bidirectionally regulating the scalp microecological balance comprises, by mass percentage: 0.1%-10% L-pyrrolidonecarboxylic acid zinc salt, 5%-20% maltooligosaccharide, 0.01%-1% cypress phenol, and the remainder is water, and the water is deionized water.

[0007] Preferably, the maltooligosaccharide comprises one or more of maltobiose, maltotriose, maltotetraose and maltopentaose, and the maltooligosaccharide is maltotetraose.

[0008] Application of a composition for bidirectionally regulating the microecological balance of the scalp. The composition for bidirectionally regulating the microecological balance of the scalp is applied to a scalp care product, wherein the scalp care product is one of shampoo, shampoo milk, conditioner, hair mask, scalp cleanser and scalp essence.

[0009] Preferably, the scalp care product is a shampoo. The raw materials for preparing the shampoo include, by mass percentage: 10%-30% surfactant, 0.1%-1.0% cationic conditioner, 0.05%-5.0% composition for bidirectionally regulating scalp microecological balance, 0.05%-0.15% chelating agent, 0.5%-1.0% preservative composition, 0%-1.5% fragrance, 0.01%-1% citric acid, and the balance is deionized water.

[0010] Preferably, the surfactant is a combination of sodium cocoylaminopropionate, sodium C14-C16 olefin sulfonate and a compound surfactant.

[0011] Preferably, by mass percentage, the sodium cocoyl aminopropionate is 0.5%-7%, the sodium C14-C16 olefin sulfonate is 2%-10%, and the compound surfactant is 2%-7%.

[0012] Preferably, the compound surfactant is selected from one or more of sodium methyl cocoyl taurate, sodium methyl cocoyl taurate, sodium cocoyl propionate, lauryl hydroxysulfobetaine, and cocamidopropyl betaine.

[0013] Preferably, the cationic conditioning agent is selected from one or more of polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-67, hydroxypropyl guar hydroxypropyltrimonium chloride, and starch hydroxypropyltrimonium chloride.

[0014] Preferably, the preparation method of the shampoo comprises the following steps: adding a cationic conditioning agent to water at room temperature and then heating while stirring, adding a surfactant, citric acid, and a chelating agent after they are completely dissolved, keeping warm and stirring at 80 degrees Celsius until they are completely dissolved, starting to cool down, and after cooling to below 50 degrees Celsius, adding a composition capable of bidirectionally regulating the microecological balance of the scalp, a preservative composition, and a fragrance in sequence, and stirring until they are completely dissolved.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The invention can be applied to scalp and hair care products, which are shampoos well known to those skilled in the art. The product has cleaning, conditioning and mild properties, and can prevent scalp inflammation by inhibiting the activity of harmful bacteria that easily cause scalp inflammation, namely Staphylococcus aureus and Malassezia, and promoting the activity of beneficial bacteria that can maintain the barrier function of the scalp, namely Staphylococcus epidermidis.

[0017] It can effectively inhibit the activity of harmful bacteria and at the same time enhance the activity of beneficial bacteria, and can regulate the balance of scalp microecology in both directions. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] The present invention provides a technical solution: a composition for bidirectionally regulating the microecological balance of the scalp, characterized in that the components of the composition for bidirectionally regulating the microecological balance of the scalp include: L-pyrrolidonecarboxylic acid zinc salt, maltooligosaccharide, cypress phenol and water. In terms of mass percentage, the composition for bidirectionally regulating the microecological balance of the scalp is: 0.1%-10% of L-pyrrolidonecarboxylic acid zinc salt, 5%-20% of maltooligosaccharide, 0.01%-1% of cypress phenol, and the balance is water, and the water is deionized water. The maltooligosaccharide contains one or more of maltobiose, maltotriose, maltotetraose and malopentaose, and the maltooligosaccharide is maltotetraose.

[0020] Analysis of the above content shows that the above composition can effectively inhibit the activity of harmful bacteria that easily cause scalp inflammation, namely Staphylococcus aureus and Malassezia, and at the same time promote the activity of beneficial bacteria that can maintain the barrier function of the scalp, namely Staphylococcus epidermidis.

[0021] The present invention provides a technical solution: application of a composition for bidirectionally regulating the microecological balance of the scalp, and application of the composition for bidirectionally regulating the microecological balance of the scalp in a scalp care product, wherein the scalp care product is one of shampoo, shampoo milk, conditioner, hair mask, scalp cleanser, and scalp essence. The scalp care product is shampoo, and the raw materials for preparing the shampoo include, by mass percentage: 10%-30% surfactant, 0.1%-1.0% cationic conditioner, 0.05%-5.0% composition for bidirectionally regulating the microecological balance of the scalp, 0.05%-0.15% chelating agent, 0.5%-1.0% preservative composition, 0%-1.5% essence, 0.01%-1% citric acid, and the remainder is deionized water. The surfactant is a combination of sodium cocoamidopropionate, sodium C14-C16 olefin sulfonate, and a compound surfactant. In terms of mass percentage, the sodium cocoylaminopropionate is 0.5%-7%, the sodium C14-C16 olefin sulfonate is 2%-10%, and the compound surfactant is 2%-7%. The cationic conditioning agent is selected from one or more of polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-67, hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride, and starch hydroxypropyl trimethyl ammonium chloride. The compound surfactant is selected from one or more of sodium methyl cocoyl taurate, sodium methyl cocoyl taurate, sodium cocoylaminopropionate, lauryl hydroxysulfobetaine, and cocamidopropyl betaine.

[0022] Analysis of the above content: The chelating agent is disodium EDTA, and the surfactant sodium cocoamidopropionate and sodium C14-C16 olefin sulfonate are used to make the shampoo mild and clean. On this basis, cationic polymers are introduced to make the shampoo smooth and tangle-free when washing hair.

[0023] The preparation method of the shampoo comprises the following steps: adding a cationic conditioning agent to water at room temperature (25° C.) and heating while stirring; adding a surfactant, citric acid and a chelating agent after the cationic conditioning agent is completely dissolved; keeping the temperature at 80° C. and stirring until the cationic conditioning agent is completely dissolved; starting to cool down; after the temperature is cooled to below 50° C., adding a composition capable of bidirectionally regulating the microecological balance of the scalp, a preservative composition and a fragrance in sequence; and stirring until the cationic conditioning agent is completely dissolved.

[0024] The reagents and instruments used in the following examples are as follows:

[0025] Bacterial activity test using bacteria and culture medium:

[0026] Staphylococcus epidermidis, trade name Staphylococcus epidermidis NBRC12993, from National Institute of Technology and Evaluation;

[0027] Staphylococcus aureus, trade name Staphylococcus aureus NBRC12732, from National Institute of Technology and Evaluation;

[0028] Malassezia, trade name Malassezia furfur NBRC0656, is from the National Institute of Technology and Evaluation.

[0029] Staphylococcus aureus culture medium, trade name NBRC802, contains 1% polypeptone, 0.2% yeast extract, 0.1% magnesium sulfate, and 98.7% water, and is sourced from the National Institute of Technology and Evaluation.

[0030] Malassezia medium, trade name YM medium, contains 1% glucose, 0.5% peptone, 0.3% yeast extract, 0.3% malt extract, and 97.9% water, and is sourced from the National Institute of Technology and Evaluation.

[0031] Reagents:

[0032] L-pyrrolidone carboxylic acid zinc salt, trade name AJIDEW ZN-100, derived from Ajinomoto;

[0033] Maltotetraose, trade name LEOGARD MT, comes from Lion;

[0034] Hinokitiol, trade name Hinokitiol, is derived from Takasago spices;

[0035] Sodium cocoamidopropionate, sold under the trade name Eversoft ACS, from SinoLion;

[0036] Sodium C14-C16 olefin sulfonate, trade name Lipolan LJ-441, from Lion;

[0037] Sodium methyl cocoyl taurate, trade name Diapon K-SF, from NOF;

[0038] Cocamidopropyl betaine, trade name AMPHITOL 55AB, from Kao;

[0039] Polyquaternium-10, trade name POIZ C-150L, ​​from Kao;

[0040] The preservative composition includes sodium benzoate 0.25% and phenoxyethanol 0.4%, and the trade names are Microcare BNA and Microcare PE, both of which are from THOR;

[0041] The remaining raw materials are commercially available.

[0042] Examples 1-5 and Comparative Examples 1-5

[0043] This embodiment and comparative example are used to illustrate the preparation method and efficacy test results of the composition capable of bidirectionally regulating the scalp microecological balance in the present invention.

[0044] Examples 1-5 are shown in Table 1, Comparative Examples 1-5 are shown in Table 2, and the test results of bacterial activity of the composition are shown in Table 3.

[0045] Preparation method of the composition: L-pyrrolidonecarboxylic acid zinc salt, maltotetraose and cypress phenol are added into water in sequence, and stirred evenly until they are completely dissolved.

[0046] Bacterial activity test method: Staphylococcus epidermidis and Staphylococcus aureus were placed in NBRC802 culture medium at 37°C, and Malassezia was placed in YM culture medium for culture. After the bacterial solution was diluted to an OD600 absorbance of 0.08-0.13 using the spectrophotometer MiniPhoto518R, it was diluted 100 times and used as the experimental bacterial solution for bacterial growth activity test. At 37°C, 180μl of bacterial solution and 20μl of the composition sample or sterile water were mixed, cultured at a constant temperature for 24 hours, and the OD600 absorbance of the culture solution for 24 hours was measured using the spectrophotometer Infinite 200Pro MPlex. The absorbance value of the mixed bacterial solution with sterile water added was the blank control. If the absorbance value was higher than the blank control, it was judged that the bacterial activity increased, and if the absorbance value was lower than the blank control, it was judged that the bacterial activity was inhibited.

[0047] Table 1. Examples 1-5

[0048]

[0049] Table 2. Comparative Examples 1-5

[0050]

[0051] Table 3. Bacterial activity test results of Examples 1-5 and Comparative Examples 1-5

[0052]

[0053]

[0054] Examples 6-10 and Comparative Examples 6-10

[0055] This embodiment and comparative example are used to illustrate the application of the composition capable of bidirectionally regulating the scalp microecological balance in shampoo, the preparation method and the efficacy test results.

[0056] Examples 6-10 are shown in Table 4, Comparative Examples 6-10 are shown in Table 5, and the shampoo efficacy test results are shown in Table 6.

[0057] The preparation method of shampoo comprises the following steps: adding a cationic conditioning agent to deionized water at 25°C and heating while stirring, adding a surfactant, citric acid and a chelating agent after they are completely dissolved, keeping the temperature at 70-85°C and stirring until they are completely dissolved, starting to cool down, adding a composition capable of bidirectionally regulating the microecological balance of the scalp, a preservative and a fragrance after the temperature is cooled to below 50°C, and stirring until they are completely dissolved.

[0058] Table 4. Examples 6-10

[0059]

[0060]

[0061] Table 5. Comparative Examples 6-10

[0062]

[0063]

[0064] Table 6. Efficacy test results of Examples 6-10 and Comparative Examples 6-10

[0065]

[0066] Cleansing power test method and standard: Volunteers were selected to wash their hair with the shampoo prepared by the present invention, and the changes in the scalp and hair of the volunteers before and after shampooing were observed using a scalp detector. The cleaning power evaluation standard is: good: no obvious sebum residue on the scalp and hair after shampooing; too high: no sebum residue on the scalp and hair after shampooing, and dry flakes were produced on the scalp due to the excessive cleaning power; too low: obvious sebum residue on the scalp and hair after shampooing.

[0067] Conditioning test method and standard: Volunteers were selected to wash their hair with the shampoo prepared by the present invention, and the volunteers were asked to judge whether the conditioning was good or not. The conditioning evaluation standard was: good: the hair was smooth during rinsing and the hair was not tangled after washing; poor: the hair felt astringent during rinsing and the hair was tangled after washing.

[0068] Test method and standard for the effect of preventing scalp inflammation: Volunteers were selected to wash their hair with the shampoo prepared by the present invention every day, and the test period was 30 days. After the test, the volunteers were asked to judge whether there was an effect of preventing and improving scalp inflammation. The judgment standard for the prevention of scalp inflammation was that there were no symptoms such as itchy head, redness, swelling, and dandruff.

[0069] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention; therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is limited by the attached claims rather than the above description, and it is intended to include all changes within the meaning and scope of the equivalent elements of the claims in the present invention.

[0070] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A composition for bidirectionally regulating the scalp microecological balance, characterized in that: The composition for bidirectionally regulating the scalp microecological balance comprises: L-pyrrolidone carboxylic acid zinc salt, maltooligosaccharide, cypress phenol and water.

2. The composition for bidirectionally regulating scalp microecological balance according to claim 1, characterized in that: Calculated by mass percentage, the composition for bidirectionally regulating the scalp microecological balance is: 0.1%-10% L-pyrrolidonecarboxylic acid zinc salt, 5%-20% maltooligosaccharide, 0.01%-1% cypress phenol, and the remainder is water, and the water is deionized water.

3. The composition for bidirectionally regulating scalp microecological balance according to claim 2, characterized in that: The maltooligosaccharide comprises one or more of maltobiose, maltotriose, maltotetraose and maltopentaose, and the maltooligosaccharide is maltotetraose.

4. The use of the composition for bidirectionally regulating scalp microecological balance according to any one of claims 1 to 3, characterized in that: The composition for bidirectionally regulating the scalp microecological balance is applied to the use of scalp care products, and the scalp care products are one of shampoo, shampoo milk, hair conditioner, hair mask, scalp cleanser and scalp essence.

5. The use of the composition for bidirectionally regulating scalp microecological balance according to claim 4, characterized in that: The scalp care product is a shampoo. The raw materials for preparing the shampoo include, by mass percentage: 10%-30% of a surfactant, 0.1%-1.0% of a cationic conditioner, 0.05%-5.0% of a composition for bidirectionally regulating the microecological balance of the scalp, 0.05%-0.15% of a chelating agent, 0.5%-1.0% of a preservative composition, 0%-1.5% of a fragrance, 0.01%-1% of a citric acid, and the remainder is deionized water.

6. The use of the composition for bidirectionally regulating scalp microecological balance according to claim 5, characterized in that: The surfactant is a combination of sodium cocoylaminopropionate, sodium C14-C16 olefin sulfonate and a compound surfactant.

7. The use of the composition for bidirectionally regulating scalp microecological balance according to claim 6, characterized in that: By mass percentage, the sodium cocoylaminopropionate is 0.5%-7%, the sodium C14-C16 olefin sulfonate is 2%-10%, and the compound surfactant is 2%-7%.

8. The use of the composition for bidirectionally regulating scalp microecological balance according to claim 4, characterized in that: The compound surfactant is selected from one or more of sodium methyl cocoyl taurate, sodium methyl cocoyl taurate, sodium cocoyl propionate, lauryl hydroxysulfobetaine, and cocamidopropyl betaine.

9. The use of the composition for bidirectionally regulating scalp microecological balance according to claim 4, characterized in that: The cationic conditioning agent is selected from one or more of polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-67, hydroxypropyl guar hydroxypropyltrimonium chloride, and starch hydroxypropyltrimonium chloride.

10. The use of the composition for bidirectionally regulating scalp microecological balance according to claim 5, characterized in that: The preparation method of the shampoo comprises the following steps: adding a cationic conditioning agent to water at room temperature and then heating while stirring; adding a surfactant, citric acid and a chelating agent after they are completely dissolved; keeping the temperature at 80 degrees Celsius and stirring until they are completely dissolved; starting to cool down; after the temperature drops to below 50 degrees Celsius, adding a composition capable of bidirectionally regulating the microecological balance of the scalp, a preservative composition and a fragrance in sequence; and stirring until they are completely dissolved.

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