Pharmaceutical composition for treating erosive gastritis and gastric ulcer

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a pharmaceutical composition for treating erosive gastritis and gastric ulcer. The pharmaceutical composition is prepared from the following components in parts by weight: 25 to 35 parts of cuttlebone, 10 to 13 parts of roxburgh rose root, 11 to 12 parts of rhizoma arisaematis, 10 to 12 parts of stephania sinica diels, 5 to 7 parts of liquorice root, 10 to 12 parts of rhizoma belamcandae and 7 to 10 parts of endothelium corneum gigeriae galli. The pharmaceutical composition provided by the invention is used for treating erosive gastritis and gastric ulcer, and has the characteristics of good absorption effect, obvious curative effect, no side effect, high safety and facilitation of timely relieving symptoms of patients.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a pharmaceutical composition for treating erosive gastritis and gastric ulcer. Background Art

[0002] With the advancement of modern society, fierce competition, a fast-paced lifestyle, high work and study pressures, mental stress, irregular lifestyles, and unhealthy diets have led to an increasing incidence of digestive system diseases. This, coupled with various factors such as long-term damage to the spleen and stomach, leading to spleen and stomach weakness, and misuse of laxatives, which damage the Zhong Yang, has significantly increased the incidence of gastrointestinal disorders. Currently, there are many treatments for gastritis, broadly categorized as Traditional Chinese Medicine (TCM), Western Medicine, and a combination of TCM and Western Medicine. TCM treatments primarily focus on strengthening the spleen and eliminating dampness.

[0003] The spleen is located in the middle burner, serving as the exterior and interior component of the stomach. Gastric disorders are characterized by dysfunction in the digestion and digestion of food, as well as a loss of harmony and descending function in the stomach, leading to upward flow of gastric qi. Common clinical symptoms include loss of appetite, abdominal distension or pain, nausea, hiccups, and belching.

[0004] The spleen is responsible for transportation and transformation, including the transportation and transformation of grain essence and moisture. The spleen and stomach are the organs that take in, digest, absorb, and distribute dietary nutrients. Splenic diseases are mainly caused by the failure of the spleen's transportation and transformation and ascending functions, resulting in the failure to transport grain and moisture, decreased digestive function, moisture retention, insufficient energy for transformation, and the inability of the spleen to regulate blood. The saying that "the spleen hates dampness" originated from Zhang Jingyue's annotation in "Su Wen Xuan Ming Wu Qi Lun": "The spleen belongs to the earth element and responds to dampness. If dampness prevails, it will damage the muscles, so it hates dampness." "The phrase 'If the spleen is affected by dampness, eat bitter food immediately to dry it out'" from Suwen (Suwen) refers to the use of bitter herbs to dry out dampness when treating spleen dampness. Spleen dampness is caused by external dampness, excessive consumption of raw and cold food, or internal dampness that traps the spleen, leading to dysfunctional spleen and stomach transport and transformation, abnormal ascending and descending functions, and accumulation of dampness. Symptoms include fatigue, a heavy head, abdominal distension, loose stools, and even edema. Symptoms of dampness are lingering and often include concurrent symptoms. Modern medicine diagnoses this as gastritis and gastric ulcers.

[0005] Patients with gastric erosion and perforation typically undergo surgery, which is painful and financially burdensome. Western medicine often has toxic side effects and adverse reactions, a narrow range of applications, and limited efficacy, often treating symptoms rather than the underlying cause, leading to relapses. Therefore, developing effective, superior, and less toxic and side-effect-reducing Traditional Chinese Medicine products for strengthening the spleen and promoting digestion is crucial. Summary of the Invention

[0006] The purpose of the present invention is to solve the above-mentioned technical problems and provide a pharmaceutical composition for treating erosive gastritis and gastric ulcer.

[0007] The technical solutions adopted are as follows:

[0008] A first aspect of the present invention provides a pharmaceutical composition for treating erosive gastritis and gastric ulcer, the pharmaceutical composition comprising the following components:

[0009] Cuttlefish sheath, sea buckthorn root, bird's nest, jewelweed, licorice, white flowered scutellaria, chicken's gizzard lining.

[0010] Preferably, the following components are included in parts by weight:

[0011] 25-35 parts of cuttlefish sheaths, 10-13 parts of rosa roxburghii roots, 11-12 parts of bird-not-suspensa, 10-12 parts of smilax china, 5-7 parts of liquorice, 10-12 parts of white belamcanda vine, and 7-10 parts of chicken's gizzard lining.

[0012] More preferably, the composition comprises the following components in parts by weight:

[0013] 30 parts of cuttlefish scabbards, 12 parts of rosa roxburghii roots, 12 parts of bird-not-staying birds, 12 parts of sweet potatoes, 6 parts of liquorice, 12 parts of white flower belamcanda, 8 parts of chicken's gizzard lining.

[0014] According to a particularly preferred embodiment, the method for preparing the pharmaceutical composition into capsules comprises: weighing the raw materials according to the weight ratio, cleaning them, placing them in a mortar, manually grinding them into powder, and then crushing, granulating, drying and packaging them according to the conventional preparation method of traditional Chinese medicine capsules.

[0015] The medicinal properties of the raw materials of the pharmaceutical composition provided by the present invention are analyzed:

[0016] Cuttlebone: Also known as cuttlefish bone. This product is the dried inner shell of the needleless squid or golden squid, both members of the family Sepiidae. The bony inner shell of the squid is collected, cleaned, and dried. It is listed in the 2015 edition of the Chinese Pharmacopoeia, Part I, page 294.

[0017] Rosa roxburghii root: invigorates the stomach, helps digestion, stops diarrhea, and astringes semen; treats stomachache, diarrhea, dysentery, spermatorrhea, metrorrhagia, leukorrhea, and chronic cough;

[0018] Niao Bu Su: In the "Compendium of Materia Medica Supplement", it is called Tiger Grass and Dull Tree; in the "Book of Collecting Medicinal Herbs", it is called Thorny Root White Bark and Bird Does Not Step; in the "Zhou Yisheng Family Prescriptions", it was once called Bird Stopping; Niao Bu Su is pungent in taste but neutral in nature. It can nourish yin and clear heat, nourish the liver and kidneys, dispel wind and dampness, promote urination, benefit joints, promote blood circulation and relieve pain. It can treat rheumatic pain, liver and kidney yin deficiency, dizziness and tinnitus, low back and knee pain, stomachache, hernia, carbuncle, leprosy neuralgia and other diseases;

[0019] Sweet potato: Also known as fragrant leaf and nine-layer roll, it can break old blood and generate new blood, treat internal injuries, vomiting blood, and has the function of promoting blood circulation and stopping bleeding. It can be used for all blood diseases.

[0020] Licorice: It is mild in nature and sweet in taste. It nourishes the spleen and replenishes Qi, clears away heat and detoxifies, moistens the lungs and relieves coughs, relieves pain, and harmonizes various medicines. It is used to treat spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, acute pain in the abdomen and limbs, carbuncles, sores and ulcers, and can alleviate the toxicity and potency of drugs.

[0021] White flowered Belamcanda: Also known as Lengshuidan, it warms the middle and dispels cold, regulates qi and relieves pain. It is used for stomach cold pain, precordial pain, and joint pain; it can also be used externally to treat sores.

[0022] Chicken gizzard lining: This product is the dried inner wall of the gizzard lining of the domesticated chicken (Phasianidae). After killing the chicken, remove the gizzard and immediately remove the inner wall beneath the gizzard lining, wash, and dry. It is listed in the 2015 edition of the Chinese Pharmacopoeia, Part I, page 193.

[0023] The pharmaceutical composition provided by the present invention is used to treat erosive gastritis and gastric ulcer, and has the characteristics of good absorption effect, significant efficacy, no side effects, high safety, and is conducive to timely relief of symptoms for patients. DETAILED DESCRIPTION

[0024] The endpoints of the ranges and any values ​​disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoints of each range, the endpoints of each range and individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered to be specifically disclosed herein.

[0025] It should be noted that, in various aspects of the present invention, for the same components in various aspects, the present invention is only described once in one aspect without repeated description, which should not be understood by those skilled in the art as a limitation of the present invention.

[0026] The present invention will be described in detail below through examples. In the following examples, unless otherwise specified, the raw materials are all commercially available.

[0027] Example 1

[0028] A pharmaceutical composition for treating erosive gastritis and gastric ulcer, comprising the following components in parts by weight:

[0029] 30 parts of cuttlefish scabbards, 12 parts of rosa roxburghii roots, 12 parts of bird-not-staying birds, 12 parts of sweet potatoes, 6 parts of liquorice, 12 parts of white flower belamcanda, 8 parts of chicken's gizzard lining.

[0030] The raw materials are weighed according to the weight ratio, cleaned, placed in a mortar, and manually ground into powder. The powder is then crushed, granulated, dried, and packaged according to a conventional preparation method of traditional Chinese medicine capsules to obtain capsules.

[0031] Example 2

[0032] A pharmaceutical composition for treating erosive gastritis and gastric ulcer, comprising the following components in parts by weight:

[0033] 35 parts of cuttlefish scabbards, 10 parts of rosa roxburghii roots, 11 parts of bird-not-staying plants, 12 parts of sweet potato fern, 5 parts of liquorice, 10 parts of white bud beam dryness, 10 parts of chicken's gizzard lining.

[0034] The raw materials are weighed according to the weight ratio, cleaned, placed in a mortar, and manually ground into powder. The powder is then crushed, granulated, dried, and packaged according to a conventional preparation method of traditional Chinese medicine capsules to obtain capsules.

[0035] Example 3

[0036] A pharmaceutical composition for treating erosive gastritis and gastric ulcer, comprising the following components in parts by weight:

[0037] 25 parts of cuttlefish scabbards, 13 parts of rosa roxburghii roots, 12 parts of bird-not-staying birds, 10 parts of sweet potatoes, 7 parts of liquorice, 12 parts of white hibiscus, and 7 parts of chicken's gizzard lining.

[0038] The raw materials are weighed according to the weight ratio, cleaned, placed in a mortar, and manually ground into powder. The powder is then crushed, granulated, dried, and packaged according to a conventional preparation method of traditional Chinese medicine capsules to obtain capsules.

[0039] The method of taking the medicine of the present invention is as follows: take four pills three times a day for 20 consecutive days; during the medication period, eat porridge for at least 25 consecutive days. This is because when the medicine is taken orally, scabs will form. The medicine provided by the present invention has the functions of anti-inflammatory and myogenic, so the scabs will fall off by themselves. If hard food is eaten, the stomach will constantly move and rub, which will make it difficult to heal, especially for erosive gastritis.

[0040] Effect verification

[0041] 300 outpatients who visited the hospital from June 2021 to December 2023 were selected. All of them met the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" promulgated by CFDA. They were divided into two groups according to the random number table method. The treatment group included 150 cases with an average age of 45.3 years and a disease course of 5 months to 31 years. The control group included 150 cases with an average age of 46.8 years and a disease course of 8 months to 29 years. All cases were clinically diagnosed as gastric disease patients, and depending on the condition, gastroscopy or upper gastrointestinal barium meal fluoroscopy, B-ultrasound, pathology and other examinations were performed to exclude epigastric pain caused by digestive system or other malignant tumors, acute and chronic pancreatitis, appendicitis, biliary or urinary stones, etc. There was no statistically significant difference between the two groups of patients in terms of gender, age, disease course, and onset (P>0.05).

[0042] Specifically, 300 gastritis and gastric ulcer patients were randomly divided into a treatment group and a control group using a randomized, positive drug parallel control design method. The primary efficacy index was the total score of TCM syndromes, and the secondary efficacy index was the single score of TCM symptoms. The efficacy results of the two treatment regimens were tested using the chi-square test. The control group was treated with conventional drugs such as omeprazole, amoxicillin, and metoclopramide, while the treatment group was treated with the pharmaceutical composition obtained in Example 1 of the present invention. Seven days constituted a course of treatment, and the efficacy was determined after four consecutive courses of treatment in both groups. The total effective rate in the treatment group was 98.6%, and that in the control group was 90.6%, with statistical significance (P < 0.05). In both groups of patients, the incidence of epigastric pain, abdominal distension or fullness, belching, pantothenic acid, nausea, and vomiting was significantly reduced (P < 0.01) compared with before treatment, and the difference between the groups was statistically significant (P < 0.05). The efficacy results of the two groups of gastropathy patients are shown in Table 1.

[0043] Table 1

[0044] n cure Improvement Not healed Adverse reactions Total effective Effectiveness / % control group 150 128 8 12 2 136 90.6 Treatment group 150 139 9 2 0 148 98.6

[0045] The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited thereto. Within the technical concept of the present invention, various simple variations of the technical solution of the present invention may be made, including combining the various technical features in any other appropriate manner. These simple variations and combinations should also be regarded as disclosed in the present invention and fall within the scope of protection of the present invention.

Claims

1. A pharmaceutical composition for treating erosive gastritis and gastric ulcer, characterized in that: The pharmaceutical composition comprises the following components: Cuttlefish sheath, sea buckthorn root, bird-not-staying, jewel-shaped, licorice, white-flowered Belamcanda chinensis, chicken's gizzard lining.

2. The pharmaceutical composition according to claim 1, wherein The composition is calculated by weight: 25-35 parts of sea cucumber sheaths, 10-13 parts of roxburghii roots, 11-12 parts of bird-not-staying plants, 10-12 parts of smilax china, 5-7 parts of liquorice, 10-12 parts of white flowered angelica, and 7-10 parts of chicken's gizzard lining.

3. The pharmaceutical composition according to claim 1 or 2, wherein The composition is calculated by weight: 30 parts of sea cucumber sheaths, 12 parts of rosa roxburghii roots, 12 parts of bird-not-staying plants, 12 parts of sweet potatoes, 6 parts of liquorice, 12 parts of white flowered angelica root, 8 parts of chicken's gizzard lining.

4. The pharmaceutical composition according to claim 1 or 2, wherein The method for preparing the pharmaceutical composition into capsules comprises: weighing raw materials according to the weight ratio, cleaning them, putting them in a mortar, manually grinding them into powder, and then crushing, granulating, drying and packaging them according to the conventional preparation method of traditional Chinese medicine capsules.