Composition with acne removing effect and application thereof
By using compositions of schizoli fermentation products, kapok flower extract and nano titanium dioxide aqueous solution, the problem of difficulty in controlling oil and removing acne in the prior art is solved, and efficient skin oil reduction and acne improvement effects are achieved.
Patent Information
- Application Number
- CN202411813010.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-10
- Publication Date
- 2025-02-25
AI Technical Summary
The prior art is difficult to effectively control oil and remove acne while reducing skin irritation, and cannot meet the high requirements of the market for acne-removing skin care products.
A composition, including schizoli fermentation products, kapok flower extract and nanotitanium dioxide aqueous solution, is used to reduce the oils of the skin and improve acne through its synergistic effect.
This composition can effectively reduce skin oils and improve acne, and the synergistic effect between ingredients is significant, achieving the dual effects of oil control and acne removal.
Smart Images
Figure BDA0005181479830000071 
Figure BDA0005181479830000081 
Figure BDA0005181479830000082
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of cosmetics and relates to a composition with acne-removing effect and application thereof. Background Art
[0002] Acne is a chronic inflammatory skin disease of the pilosebaceous gland unit. The clinical symptoms are characterized by polymorphic skin lesions such as acne, papules, pustules, and nodules on the face. The occurrence of acne is mainly related to increased secretion of sebaceous glands, increased release of androgens, blockage of pilosebaceous glands, inflammation, and proliferation of Propionibacterium acnes. It may also be related to environmental, psychological, genetic, and other microbial infections.
[0003] Factors such as fast-paced lifestyle, irregular daily routine and environmental pollution have led to an increasing number of people with acne-prone skin, making anti-acne skin care products the focus of market attention. Driven by the "appearance economy", consumers have higher and higher requirements for appearance. As one of the important means to improve skin condition, the market demand for anti-acne skin care products has also increased accordingly.
[0004] Therefore, developing a composition that can reduce the irritation of the product to the skin while effectively controlling oil and removing acne is a research focus in this field. Summary of the invention
[0005] In view of the deficiencies in the prior art, the object of the present invention is to provide a composition with acne-removing effect and its application.
[0006] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:
[0007] In a first aspect, the present invention provides a composition with acne-removing effect, the composition comprising a fermentation product of Schizophyllum, a kapok flower extract and a nano titanium dioxide aqueous solution.
[0008] The composition of the present invention can reduce skin oil and improve acne, and the components cooperate with each other to have a certain synergistic effect.
[0009] Preferably, the composition comprises, by mass, 4-6 parts of Schizophyllum fermentation product, 1-3 parts of Kapok extract and 15-25 parts of nano titanium dioxide aqueous solution.
[0010] The mass fractions of the schizophyllum fermentation product can be selected from 4 parts, 4.2 parts, 4.4 parts, 4.6 parts, 4.8 parts, 5 parts, 5.2 parts, 5.4 parts, 5.6 parts, 5.8 parts, 6 parts, etc., the mass fractions of the kapok flower extract can be selected from 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, etc., the mass fractions of the nano titanium dioxide aqueous solution can be selected from 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, etc., and other specific points within the above numerical range can be selected, so they will not be elaborated here one by one.
[0011] Preferably, the mass percentage of nano-titanium dioxide in the nano-titanium dioxide aqueous solution is 0.00001%-0.0001%.
[0012] For example, 0.00001%, 0.00002%, 0.00003%, 0.00004%, 0.00005%, 0.00006%, 0.00007%, 0.00008%, 0.00009%, 0.0001%, etc. Other specific point values within the above numerical range can be selected and will not be listed here one by one.
[0013] In a second aspect, the present invention provides a use of the composition with acne-removing effect according to the first aspect in the preparation of cosmetics.
[0014] Preferably, the added amount of the composition in the cosmetic is 20-44%, for example 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, 40%, 42%, 44%, etc. Other specific points within the above numerical range can be selected and will not be described here one by one.
[0015] Preferably, the cosmetics include skin care lotion, emulsion, essence or facial mask.
[0016] In a third aspect, the present invention provides a skin care water with acne-removing effect, wherein the skin care water with acne-removing effect comprises the composition with acne-removing effect described in the first aspect, a moisturizer, a thickener and water.
[0017] Preferably, the skin care water with acne-removing effect comprises, by mass percentage, 20-44% of the composition with acne-removing effect described in the first aspect, 6-10% of a moisturizer, 0.3-0.7% of a thickener and water.
[0018] The mass percentage of the composition with acne-removing effect can be selected from 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, 40%, 42%, 44% and the like; the mass percentage of the moisturizer can be selected from 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10% and the like; the mass percentage of the thickener can be selected from 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.65%, 0.7% and the like; other specific point values within the above numerical range can be selected, which will not be described one by one here.
[0019] Preferably, the humectant comprises glycerin and / or butylene glycol.
[0020] Preferably, the thickener comprises carbomer and / or acrylates / C10-30 alkyl acrylate crosspolymer.
[0021] Preferably, the skin care water with anti-acne effect further comprises any one of a skin conditioner, a pH adjuster or a preservative, or a combination of at least two of them.
[0022] Preferably, the skin care water with acne-removing effect further comprises, by weight percentage, any one of 5.1-9.2% of a skin conditioner, 0.2-0.4% of a pH adjuster, or 1.05-1.7% of a preservative, or a combination of at least two thereof.
[0023] The mass percentage of the skin conditioner can be selected from 5.1%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.2% and the like; the mass percentage of the pH adjuster can be selected from 0.2%, 0.22%, 0.24%, 0.26%, 0.28%, 0.3%, 0.32%, 0.34%, 0.36%, 0.38%, 0.4% and the like; the mass percentage of the preservative can be selected from 1.05%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7% and the like; other specific point values within the above numerical range can be selected, and they will not be elaborated here one by one.
[0024] Preferably, the skin conditioning agent comprises dipotassium glycyrrhizinate.
[0025] Preferably, the pH adjuster comprises aminomethyl propanol.
[0026] Preferably, the preservative comprises caprylhydroxamic acid and / or ethylhexylglycerin.
[0027] In a fourth aspect, the present invention provides a method for preparing the skin care water with acne-removing effect according to the third aspect, the method comprising:
[0028] (1) mixing water, a moisturizing agent, and a thickener, homogenizing, and keeping warm to obtain a first mixture;
[0029] (2) The first mixture is mixed with a composition having acne-removing effect to obtain a product.
[0030] Preferably, the homogenization speed in step (1) is 2500-3500 rpm and the time is 3-5 min.
[0031] The speed can be selected as 2500rpm, 2600rpm, 2700rpm, 2800rpm, 2900rpm, 3000rpm, 3100rpm, 3200rpm, 3300rpm, 3400rpm, 3500rpm, etc. and the time can be selected as 3min, 3.2min, 3.4min, 3.6min, 3.8min, 4min, 4.2min, 4.4min, 4.6min, 4.8min, 5min, etc. Other specific point values within the above numerical range can be selected, so they will not be elaborated here.
[0032] Preferably, the mixing temperature in step (1) is 80-90° C. and the mixing time is 8-15 min.
[0033] The temperature can be selected as 80℃, 81℃, 82℃, 83℃, 84℃, 85℃, 86℃, 87℃, 88℃, 89℃, 90℃, etc. The time can be selected as 8min, 9min, 10min, 11min, 12min, 13min, 14min, 15min, etc. Other specific point values within the above numerical range can be selected, so they will not be elaborated here.
[0034] Preferably, the insulation time in step (1) is 15-25 min, for example, 15 min, 16 min, 17 min, 18 min, 19 min, 20 min, 21 min, 22 min, 23 min, 24 min, 25 min, etc. Other specific point values within the above numerical range can be selected, and they will not be described one by one here.
[0035] Preferably, the first mixture further comprises mixing with a pH adjuster before mixing with the composition having acne-removing efficacy.
[0036] Preferably, the temperature of mixing with the pH adjuster is 55-65°C, for example, 55°C, 56°C, 57°C, 58°C, 59°C, 60°C, 61°C, 62°C, 63°C, 64°C, 65°C, etc. Other specific points within the above numerical range can be selected and will not be described here one by one.
[0037] Preferably, step (2) further comprises mixing with a preservative and / or a skin conditioner when mixing with the composition having acne-removing efficacy.
[0038] Preferably, the mixing temperature in step (2) is 40-50° C. and the mixing time is 25-35 min.
[0039] The temperature can be selected as 40℃, 41℃, 42℃, 43℃, 44℃, 45℃, 46℃, 47℃, 48℃, 49℃, 50℃, etc. The time can be selected as 25min, 26min, 27min, 28min, 29min, 30min, 31min, 32min, 33min, 34min, 35min, etc. Other specific point values within the above numerical range can be selected, so they will not be elaborated here.
[0040] Compared with the prior art, the present invention has the following beneficial effects:
[0041] The composition of the present invention can reduce skin oil and improve acne, and the components cooperate with each other to have a certain synergistic effect. DETAILED DESCRIPTION
[0042] The technical solution of the present invention is further described below by specific implementation methods. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention.
[0043] The sources of the functional ingredients contained in the products involved in the following embodiments and comparative examples are as follows (only the functional ingredients are reflected, and the necessary auxiliary ingredients contained in other commercially available raw materials are not repeated):
[0044] The fermentation product of Schizophyllum was purchased from Best Pharmaceutical (Guangzhou) Co., Ltd. under the trade name of Xishiyin;
[0045] Kapok flower extract was purchased from Best Pharmaceutical (Guangzhou) Co., Ltd. under the trade name of supramolecular kapok flower;
[0046] Nano titanium dioxide aqueous solution was purchased from Huachuang Times Investment Holdings (Shenzhen) Co., Ltd. under the trade name of titanium dioxide;
[0047] Carbomer is available from Lubrizol Advanced Materials under the trade name 981POLYMER products;
[0048] Acrylates / C10-30 Alkyl Acrylate Crosspolymer was purchased from Lubrizol Advanced Materials under the trade name Products of ULTREZ 21POLYMER.
[0049] Example 1
[0050] This embodiment provides a composition with acne-removing effect, which comprises, by mass, 5 parts of Schizophyllum fermentation product, 2 parts of Kapok extract and 20 parts of nano titanium dioxide aqueous solution.
[0051] The preparation method thereof is as follows: physically mixing the preparation raw materials to obtain the product.
[0052] Example 2
[0053] This embodiment provides a composition with acne-removing effect, which comprises, by mass, 4 parts of Schizophyllum fermentation product, 3 parts of kapok extract and 15 parts of nano titanium dioxide aqueous solution.
[0054] The preparation method is similar to that of Example 1.
[0055] Example 3
[0056] This embodiment provides a composition with acne-removing effect, which comprises, by mass, 6 parts of Schizophyllum fermentation product, 1 part of Kapok extract and 25 parts of nano titanium dioxide aqueous solution.
[0057] The preparation method is similar to that of Example 1.
[0058] Comparative Example 1
[0059] This comparative example provides a composition with acne-removing effect, which is different from Example 1 only in that it does not contain Schizophyllum fermentation product, and its reduced mass is proportionally distributed to the mass of kapok extract and nano titanium dioxide aqueous solution.
[0060] The preparation method is similar to that of Example 1.
[0061] Comparative Example 2
[0062] This comparative example provides a composition with acne-removing effect, which is different from Example 1 only in that it does not contain kapok flower extract, and its reduced mass is proportionally distributed to the mass of Schizophyllum fermentation product and nano titanium dioxide aqueous solution.
[0063] The preparation method is similar to that of Example 1.
[0064] Comparative Example 3
[0065] This comparative example provides a composition with acne-removing effect, which is different from Example 1 only in that it does not contain nano titanium dioxide aqueous solution, and its reduced mass is proportionally distributed to the mass of the Schizophyllum fermentation product and the kapok flower extract.
[0066] The preparation method is similar to that of Example 1.
[0067] Application Example 1
[0068] This application example provides a skin care water with acne-removing effect, and its formula is as follows:
[0069]
[0070] Its preparation method is:
[0071] (1) mixing water, a moisturizing agent, and a thickener at 85° C. for 10 minutes, homogenizing at 3000 rpm for 4 minutes, and keeping the mixture warm for 20 minutes to obtain a first mixture;
[0072] (2) The first mixture is mixed with the pH adjuster at 60° C., and then mixed with the composition, the skin conditioner and the preservative at 45° C. for 30 minutes to obtain the product.
[0073] Application Example 2
[0074] This application example provides a skin care water with acne-removing effect, and its formula is as follows:
[0075]
[0076] Its preparation method is:
[0077] (1) mixing water, a humectant, and a thickener at 80° C. for 15 minutes, homogenizing at 2500 rpm for 5 minutes, and keeping the mixture warm for 25 minutes to obtain a first mixture;
[0078] (2) The first mixture is mixed with the pH adjuster at 55° C., and then mixed with the composition, the skin conditioner and the preservative at 40° C. for 35 minutes to obtain the product.
[0079] Application Example 3
[0080] This application example provides a skin care water with acne-removing effect, and its formula is as follows:
[0081]
[0082]
[0083] Its preparation method is:
[0084] (1) mixing water, a moisturizing agent, and a thickener at 90° C. for 8 minutes, homogenizing at 3500 rpm for 3 minutes, and keeping the mixture warm for 15 minutes to obtain a first mixture;
[0085] (2) The first mixture is mixed with the pH adjuster at 65° C., and then mixed with the composition, the skin conditioner and the preservative at 50° C. for 25 minutes to obtain the product.
[0086] Comparative Application Examples 1-3
[0087] This comparative application example provides three skin care waters with acne-removing effects, which differ from application example 1 only in that the composition of example 1 is replaced by the compositions of comparative examples 1-3 in equal amounts, and other ingredients and contents remain unchanged.
[0088] The preparation method refers to Application Example 1.
[0089] Test Example 1
[0090] In vitro antibacterial test
[0091] (1) Preparation of bacterial solution: Staphylococcus epidermidis CMCC (B) 26069, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 27853, and Propionibacterium acnes ATCC 11827 were inoculated into the corresponding culture medium and cultured to adjust the viable bacterial count to 5 × 10 4 CFU / mL or so.
[0092] (2) Inoculation: 5 mL of the composition prepared in Example 1-3 and Comparative Example 1-3 was mixed with 100 μL of bacterial solution for 2 min, 5 min, 10 min, and 20 min, respectively. The sample solution (0.5 mL) after inoculation was put into a test tube containing 5 mL of PBS and mixed evenly. Gradient dilution was performed, and an appropriate dilution degree (the number of colonies on the plate was 30-300) was selected. 0.5 mL of the mixture of sample and bacterial solution was respectively drawn and placed in a plate (two replicates were made for each sample), and 15 mL of culture medium was poured and mixed evenly. For the control group, an equal volume of PBS was mixed with the bacterial solution. After the culture medium solidified, the plate was turned over and placed in an incubator. Bacteria were cultured for 2 days, fungi were cultured for 5 days, and counted.
[0093] (3) Data processing: Count the culture results and calculate the sample inhibition rate.
[0094]
[0095] The results are shown in Tables 1-4, wherein Table 1 shows the inhibition rate against Staphylococcus epidermidis, Table 2 shows the inhibition rate against Staphylococcus aureus, Table 3 shows the inhibition rate against Pseudomonas aeruginosa, and Table 4 shows the inhibition rate against Propionibacterium acnes.
[0096] Table 1
[0097]
[0098] Table 2
[0099]
[0100] Table 3
[0101]
[0102] Table 4
[0103]
[0104] According to the in vitro antibacterial test, the composition obtained in the present application has an inhibition rate of more than 80% on microorganisms, and has obvious antibacterial and anti-acne effects. In addition, there is a potential synergistic effect among the several components.
[0105] Test Example 2
[0106] In vitro 5α-reductase inhibition test
[0107] Test method:
[0108] (1) Preparation of 96-well microplates: Using a 5α-reductase (5AR) ELISA detection kit, the sample solution (divided into 0.1% group, 1.0% group, and 3.0% group), the negative control group added first-grade water, and the positive control group added 0.5 mg / mL finasteride were added to the 96-well plate pre-coated with 5α-reductase antibody, with a volume of 33.33 μL. Then, 16.67 μL of 5α-reductase and 100 μL of HRP-labeled antibody solution were added to the sample solution, negative control group, and positive control group wells, respectively. Three parallel wells were prepared for each test group.
[0109] (2) Incubation at 37°C: After adding the sample, seal the 96-well microplate with a sealing film and place it in a constant temperature water bath oscillator for 30 minutes at 37°C.
[0110] (3) Plate washing: After the plate is incubated at 37°C for 30 minutes, carefully remove the sealing film, discard the liquid, and gently shake dry. Dilute the 30-fold concentrated washing solution with 30-fold distilled water as the washing solution for the plate. Fill each well with washing solution, let it stand for 30 seconds, then discard the liquid and gently shake dry. Repeat this process 5 times and gently pat dry with a dry towel.
[0111] (4) Add enzyme: Add 100 μL of HRP enzyme-labeled reagent to each well, except for the blank well.
[0112] (5) Incubation at 37°C: Same steps as (2).
[0113] (6) Plate washing: The operation steps are the same as (3).
[0114] (7) TMB color development: First, add 50 μL of TMB color developer solution (purchased from Merck KGaA, Darmstadt, Germany) to each well, then add 50 μL of TMB color developer solution B, gently shake to mix, and color develop at 37°C in the dark for 10 min.
[0115] (8) Stop color development: Add 50 μL of stop solution (purchased from Beijing Biolab Technology Co., Ltd.) to each well to stop the TMB color development reaction (the blue color immediately turns yellow).
[0116] (9) Absorbance measurement: Set the test wavelength of the microplate reader to 450 nm and measure the absorbance (OD value) of each well in sequence. The measurement should be completed within 15 minutes after adding the stop color development.
[0117] (10) Data processing: Calculate the inhibition rate.
[0118]
[0119] Where:
[0120] A0: absorbance value of negative reaction group
[0121] B0: Absorbance value of sample reaction group
[0122] Table 5
[0123]
[0124] The 5α-reductase inhibition rate of the positive control group was 17.63%, the 5α-reductase inhibition rate of the negative control group was 0, and the 5α-reductase inhibition rate of Examples 1-3 was significantly higher than that of Comparative Examples 1-3, indicating that the fermentation product of Schizophyllum corytatum, kapok flower extract and nano-titanium dioxide have a certain synergistic effect on 5α-reductase inhibition.
[0125] Test Example 3
[0126] Oil control efficacy test
[0127] Test parameters: skin color a* value, skin oil content
[0128] (1) Test products: Application examples 1-3, comparative application examples 1-3
[0129] (2) Number of subjects: 36, 6 in each group
[0130] Inclusion criteria: Oily or mixed oily skin with obvious acne on the face.
[0131] (3) Test site: face
[0132] (4) Usage: After cleansing the facial skin with a facial cleanser, use it once in the morning and once in the afternoon in a lighted environment (preferably sunlight). Use during the day, with a single dose of 1.5 g.
[0133] (5) Test instruments: Sebumeter SM815, VISIA-CR
[0134] (6) Test environment: 21±1℃, 50±10%RH
[0135] (7) Test period: 14 days
[0136] (8) Test time: D0, D1, D3, D7, D14
[0137] (9) Parameter explanation: The lower the skin color a* value, the less red the skin is; the lower the skin oil content value, the less oil the skin is.
[0138] The test results of skin oil content are shown in Table 6, and the test results of skin color a* value are shown in Table 7.
[0139]
[0140] Table 6
[0141] D1 change rate (%) D3 change rate (%) D7 change rate (%) D14 change rate (%) Application Example 1 -35.79 -46.84 -57.37 -60.00 Application Example 2 -34.26 -44.35 -56.34 -58.95 Application Example 3 -32.93 -40.12 -52.33 -55.88 Comparative application example 1 -20.77 -21.80 -32.32 -45.43 Comparative Application Example 2 -18.25 -19.67 -21.05 -21.93 Comparative Application Example 3 -15.20 -16.33 -19.12 -21.21
[0142] Table 7
[0143]
[0144]
[0145] It can be seen from Table 6 and Table 7 that the composition of the present application has the effects of controlling oil and reducing skin redness, and the several components of the composition have potential mutual cooperation.
[0146] Test Example 4
[0147] Acne-removing efficacy test
[0148] 60 volunteers with oily skin and large facial acne aged 18-55 were selected and randomly divided into 6 groups, each with 10 people. Each group used the products of Application Examples 1-3 and Comparative Application Examples 1-3. After cleaning the facial skin with facial cleanser, they were used once in the morning and once in the afternoon in a lighted environment. They were used every day for 14 consecutive days. During this period, no other acne-removing products were used. The usage and operation were basically the same. After 14 days, the acne symptom cleansing effect of the product was scored and evaluated, with the highest score being 5 points and the lowest score being 1 point. The score range was 1-5. The evaluation results are shown in Table 8 (average score)
[0149] Table 8
[0150] D14 acne repair effect Application Example 1 4.2 Application Example 2 3.9 Application Example 3 3.8 Comparative application example 1 2.5 Comparative Application Example 2 2.1 Comparative Application Example 3 2.2
[0151] It can be seen from Table 8 that the product containing the composition of the present application has a good acne-removing effect, and several ingredients are indispensable.
[0152] Test Example 5
[0153] Safety Testing
[0154] The products of Application Examples 1-3 and Comparative Application Examples 1-3 were tested for skin irritation. 60 subjects were selected, and the patch test tape containing 0.1g of the sample was applied to the normal skin of the left and right forearms of the subjects. After the patch was removed, the test was carried out according to the CTFA Guide (1981) within half an hour, and a total of 6 times. On the 6th day after the skin was applied, an additional test was carried out to observe the delayed reaction. The identification standards are shown in Table 9, and the results are shown in Table 10.
[0155] Table 9
[0156] grade symbol Identification criteria 0 - Negative reaction: no irritation, no erythema 1 ± Suspected reaction: Mild erythema 2 + Weak positive reaction: erythema 3 ++ Strong positive reaction: erythema, papules, blisters 4+ +++ Very positive reaction: severe edema, large bullae
[0157] Table 10
[0158]
[0159] The applicant declares that the present invention illustrates a composition with acne-removing effect and its application through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.
[0160] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.
[0161] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.
Claims
1. A composition having acne-removing effect, characterized in that: The composition comprises a fermentation product of Schizophyllum, a kapok flower extract and a nano titanium dioxide aqueous solution.
2. The composition with acne-removing effect according to claim 1, characterized in that: The composition comprises, by weight, 4-6 parts of a Schizophyllum fermentation product, 1-3 parts of a Kapok extract and 15-25 parts of a nano titanium dioxide aqueous solution; Preferably, the mass percentage of nano-titanium dioxide in the nano-titanium dioxide aqueous solution is 0.00001%-0.0001%.
3. Use of the composition with acne-removing effect according to claim 1 or 2 in the preparation of cosmetics.
4. The use according to claim 3, characterized in that: The amount of the composition added to the cosmetic is 20-44%; Preferably, the cosmetics include skin care lotion, emulsion, essence or facial mask.
5. A skin care water with acne-removing effect, characterized in that: The skin care water with acne-removing effect comprises the composition with acne-removing effect according to claim 1 or 2, a moisturizer, a thickener and water.
6. The skin care water with acne-removing effect according to claim 5, characterized in that: The skin care water with acne-removing effect comprises, by weight percentage, 20-44% of the composition with acne-removing effect according to claim 1 or 2, 6-10% of a moisturizer, 0.3-0.7% of a thickener and water; Preferably, the humectant comprises glycerin and / or butylene glycol; Preferably, the thickener comprises carbomer and / or acrylates / C10-30 alkyl acrylate crosspolymer.
7. The skin care water with acne-removing effect according to claim 5 or 6, characterized in that: The skin care water with acne-removing effect further comprises any one of a skin conditioner, a pH adjuster or a preservative, or a combination of at least two thereof; Preferably, the skin care water with acne-removing effect further comprises, by weight percentage, any one of 5.1-9.2% of a skin conditioner, 0.2-0.4% of a pH adjuster, or 1.05-1.7% of a preservative, or a combination of at least two thereof; Preferably, the skin conditioning agent comprises dipotassium glycyrrhizinate; Preferably, the pH adjuster comprises aminomethyl propanol; Preferably, the preservative comprises caprylhydroxamic acid and / or ethylhexylglycerin.
8. A method for preparing a skin care water with acne-removing effect according to any one of claims 5 to 7, characterized in that: The preparation method comprises: (1) mixing water, a moisturizing agent, and a thickener, homogenizing, and keeping warm to obtain a first mixture; (2) The first mixture is mixed with a composition having acne-removing effect to obtain a product.
9. The method for preparing the skin care water with acne-removing effect according to claim 8, characterized in that: The homogenization speed in step (1) is 2500-3500 rpm and the time is 3-5 min; Preferably, the mixing temperature in step (1) is 80-90°C and the mixing time is 8-15 minutes; Preferably, the insulation time in step (1) is 15-25 minutes.
10. The method for preparing the skin care water with acne-removing effect according to claim 8 or 9, characterized in that: The first mixture further comprises mixing with a pH adjuster before mixing with the composition having acne-removing efficacy; Preferably, the temperature of mixing with the pH adjuster is 55-65°C; Preferably, step (2) further comprises mixing with a preservative and / or a skin conditioner when mixing with the composition having acne-removing efficacy; Preferably, the mixing temperature in step (2) is 40-50° C. and the mixing time is 25-35 min.