Traditional Chinese medicine composition for treating idiopathic oligospermia and asthenospermia

Abstract

The invention discloses a traditional Chinese medicine composition for treating idiopathic oligospermia, which relates to the technical field of Chinese herbal medicines, and is characterized in that the composition is a medicament prepared from the following raw material medicines by weight: 40-50 g of pilose antler, 40-50 g of hippocampus, 50-70 g of ginseng, 20-40 g of cistanche, 10-30 g of epimedium, 10-30 g of schisandra chinensis, 30-50 g of semen cuscutae, 20-40 g of medlar, 5-15 g of fructus psoraleae, 10-20 g of pericarpium citri reticulatae and 5-15 g of cuttlebone. The traditional Chinese medicine composition for treating idiopathic oligospermia and asthenospermia forms a more effective treatment method, and has great significance in improving sperm quality of patients with idiopathic oligospermia and asthenospermia, improving fertility of the patients, improving sexual dysfunction and promoting healthy development of social population.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese herbal medicines, and more particularly to a Chinese medicinal composition for treating idiopathic oligospermia and asthenospermia. Background Art

[0002] Male infertility has become a common problem in clinical reproductive medicine, affecting about 15% of couples of childbearing age, of which 50% are male factors. Common factors leading to male infertility include reduced sperm concentration (oligospermia) and weakened sperm motility (asthenospermia), which often occur together and are called oligospermia and asthenospermia. About 30% of cases of oligospermia and asthenospermia are idiopathic, that is, the cause is unknown. In modern society, factors such as life pressure, environmental pollution and bad living habits have caused the incidence of oligospermia, asthenospermia, male sexual dysfunction and infertility to increase year by year, bringing tremendous pressure to families and society.

[0003] The disease name "oligospermia" is not specifically recorded in ancient Chinese medical books, but it can be classified into the categories of "cold sperm", "cold semen" or "childlessness" according to clinical manifestations. The Yellow Emperor's Classic of Internal Medicine proposed a fertility concept centered on the kidney, emphasized the importance of the kidney in reproduction, and laid a theoretical foundation for later doctors to treat infertility. In the Han Dynasty, Zhang Zhongjing's Synopsis of the Golden Chamber recorded the pulse related to this disease: "A man's pulse is floating and astringent, which means he is childless." Zhang Zhongjing believed that a man's pulse should be strong, floating means yin deficiency, and astringent means deficiency of essence and qi. Insufficient yin and yang essence and qi will lead to cold and unwarm sperm, affecting fertility. For this reason, he created Guizhi Jia Longgu Muli Decoction to treat infertility. The Schisandra chinensis mentioned in Shennong's Herbal Classic has the effect of "strengthening yin and benefiting male essence", which is also an early record of the symptoms of "childlessness" or "sterilization".

[0004] Modern Chinese medical scholars have further studied the etiology and pathogenesis of oligospermia and asthenospermia on the basis of the ancients. In the prior art, oligospermia and asthenospermia are mainly treated by tonifying the kidneys and spleen and stomach, and attention is paid to factors such as damp heat, phlegm and blood stasis. Its kidney deficiency, damp heat, and blood stasis are the main pathological mechanisms of this disease, with kidney deficiency as the root and damp heat and blood stasis as the manifestation. The views of doctors in successive dynasties on oligospermia and asthenospermia are also different. It is believed that its causes include congenital deficiency, acquired malnutrition, improper diet, internal injuries caused by seven emotions, excessive loss, etc. The main pathogenesis can be summarized as kidney deficiency, spleen deficiency, liver depression, qi stagnation, qi and blood deficiency, etc. With the development of modern diagnosis and treatment technology and the research of a large number of scientific researchers, modern Chinese medicine andrology experts have a deeper understanding of the etiology and pathogenesis of oligospermia and asthenospermia. Regardless of the pathogenesis, the kidney is always regarded as the core of human reproduction. At present, the treatment of idiopathic oligospermia and asthenospermia mainly relies on hormone activation drugs, such as clomiphene, which can effectively promote hormone secretion in the body, thereby promoting the growth and development of sperm.

[0005] Therefore, the present invention provides a Chinese medicine composition for treating idiopathic oligospermia and asthenospermia to form a more effective treatment method, which is of great significance for improving the sperm quality of patients with idiopathic oligospermia, improving their fertility, and improving sexual dysfunction, and promoting the healthy development of the social population. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating idiopathic oligospermia and asthenospermia, which adopts a self-prepared Haima Shenrong Pill as an auxiliary treatment method, combined with the traditional treatment of clomiphene combined with vitamin E to treat idiopathic oligospermia and asthenospermia, aiming to explore the potential of traditional Chinese medicine in improving male infertility, especially idiopathic oligospermia and asthenospermia.

[0007] The above technical purpose of the present invention is achieved through the following technical scheme: a Chinese medicine composition for treating idiopathic oligospermia and asthenospermia, the composition is a medicament made of the following raw materials by weight: 40-50g of pilose antler, 40-50g of hippocampus, 50-70g of ginseng, 20-40g of Cistanche deserticola, 10-30g of epimedium, 10-30g of Schisandra chinensis, 30-50g of Cuscuta australis, 20-40g of wolfberry, 5-15g of psoralea corylifolia, 10-20g of tangerine peel, and 5-15g of cuttlebone.

[0008] Preferably, the present invention is further configured as: the composition is a medicament made of the following raw materials by weight, 45g of pilose antler, 45g of seahorse, 60g of ginseng, 30g of Cistanche deserticola, 20g of Epimedium, 20g of Schisandra chinensis, 40g of Cuscuta australis, 30g of Lycium barbarum, 10g of Psoralea corylifolia, 15g of tangerine peel, and 10g of cuttlebone.

[0009] The pharmacological properties of the drug of the present invention are as follows:

[0010] Deer antler: warm, enters the kidney and liver meridians; warms the kidney and strengthens yang, replenishes essence and marrow, and strengthens tendons and bones; Deer antler contains a variety of amino acids, minerals and hormone components, which can promote cell regeneration and enhance immune function;

[0011] Seahorse: warm, enters the kidney and liver meridians; nourishes the kidney and strengthens yang, regulates qi and blood, and enhances physical strength; seahorse is rich in a variety of trace elements and bioactive substances, can improve sexual function and blood circulation;

[0012] Ginseng: slightly warm, enters the spleen, lung, heart, and kidney meridians; greatly replenishes vital energy, strengthens the spleen and lungs, promotes the production of body fluids and calms the mind; ginseng contains ginsenosides, amino acids, and vitamins, which help to enhance physical strength, improve immune function, and resist fatigue;

[0013] Cistanche deserticola: warm, enters the kidney and large intestine meridians; replenishes kidney yang, benefits essence and blood, moistens the intestines and promotes bowel movements; Cistanche deserticola is rich in phenylethanol glycosides and polysaccharides, which can enhance sexual function and improve gastrointestinal function;

[0014] Epimedium: warm, enters the liver and kidney meridians; nourishes the kidney and strengthens yang, strengthens tendons and bones, and eliminates rheumatism; Epimedium contains flavonoids, which can enhance sexual function and improve sperm quality;

[0015] Schisandra: warming, enters the lung, heart, and kidney meridians; astringent, replenishing qi and promoting body fluid, nourishing the kidney and calming the mind; Schisandra is rich in schisandrin and other ingredients, which can protect the liver, enhance immunity, and improve cardiovascular function;

[0016] Cuscuta: neutral, enters the liver, kidney, and spleen meridians; has the effects of nourishing the kidney and essence, nourishing the liver and improving eyesight, and stopping diarrhea. Cuscuta contains a variety of flavonoids and glycosides, which can promote reproductive function and improve sperm motility.

[0017] Lycium barbarum: neutral, enters the liver and kidney meridians; nourishes the liver and kidneys, improves the eyesight, and moistens the lungs; Lycium barbarum is rich in polysaccharides, carotene and vitamins, which can improve immunity and resist fatigue;

[0018] Psoralea corylifolia: warming, enters the kidney and spleen meridians; warms the kidney and strengthens yang, replenishes essence and qi, stops diarrhea and relieves asthma; Psoralea corylifolia contains ingredients such as psoralen and isopsoralen, which can enhance sexual function and improve urinary system function;

[0019] Tangerine peel: warm, enters the spleen and lung meridians; regulates qi and strengthens the spleen, dries dampness and resolves phlegm; tangerine peel contains volatile oils, flavonoids and a variety of organic acids, which can promote digestion and improve gastrointestinal function;

[0020] Cuttlebone: slightly warm, enters the liver and kidney meridians; astringent and hemostatic, consolidates essence and stops leukorrhea, reduces acidity and relieves pain; Cuttlebone contains calcium, carbonates and organic matter, which can improve urinary system function and promote wound healing.

[0021] The therapeutic mechanism of the present invention is as follows: the medicinal materials such as velvet antler, seahorse, ginseng, cistanche and epimedium of the present invention mainly improve sexual function by tonifying the kidney and strengthening yang, enhancing energy and physical strength, the warming properties of velvet antler and seahorse help to stimulate the body's yang energy, increase the level of male hormones in the body, and improve the quantity and quality of sperm, ginseng and cistanche replenish vitality and enhance overall physical fitness, and epimedium further improves sperm motility and reproductive health through its flavonoid compounds;

[0022] The ginseng, seahorse and other medicinal materials of the present invention have the function of regulating qi and blood, can improve blood circulation, enhance cardiovascular function, and enable the reproductive system to obtain better blood supply and nutrition. Schisandra chinensis improves the body's overall immunity and protects liver health through its function of invigorating qi and promoting body fluid, thereby indirectly promoting the recovery of reproductive function.

[0023] The Chinese wolfberry, dodder seed and other medicinal materials of the present invention have the functions of nourishing the liver, improving eyesight and enhancing immunity. Chinese wolfberry is rich in vitamins and polysaccharides, which can improve the body's immunity, resist fatigue, and enhance the vitality and survival ability of sperm. Dodder seed promotes the health of the reproductive system and the production of sperm through its function of nourishing the kidney and replenishing sperm; Tangerine peel has the functions of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, can promote digestive function, improve nutrient absorption, thereby providing the body with necessary energy and nutrients, supporting the health of the reproductive system, and good digestive function helps to give full play to the efficacy of the medicine, ensuring that the drug ingredients are effectively absorbed and utilized;

[0024] The Schisandra chinensis and the cuttlebone of the invention have the functions of astringing, consolidating and protecting the urinary system. The consolidating effect of the Schisandra chinensis can prevent excessive loss of semen and maintain the quantity and quality of sperm. The cuttlebone improves the function of the urinary system, promotes wound healing and protects the health of the reproductive system through its effects of antacidity, analgesia, consolidating semen and stopping leukorrhea. The Cistanche deserticola has the effect of moistening the intestines and relieving constipation, can improve gastrointestinal function, promote defecation, thereby helping the body to eliminate toxins and keep the internal environment clean and healthy, which is of great significance to the overall health and the normal function of the reproductive system.

[0025] The Chinese medicine composition works synergistically through multiple pathways to comprehensively nourish the kidney and strengthen yang, regulate qi and blood, enhance immunity, promote digestion and absorption, protect the urinary system, and eliminate toxins in the body, thereby effectively improving idiopathic oligospermia and asthenospermia, improving the quality and quantity of sperm, enhancing overall physical fitness, and achieving the purpose of treatment.

[0026] The present invention is further configured as follows: for patients with symptoms of decreased appetite, the Chinese medicine composition also includes Atractylodes macrocephala, Codonopsis pilosula, stir-fried rice sprouts, and Jianqu.

[0027] By adopting the above technical scheme, the additionally added Atractylodes macrocephala in the present invention has the following medicinal properties: warm, and enters the spleen and stomach meridians. Atractylodes macrocephala can strengthen the digestion and absorption function by strengthening the spleen and replenishing qi, and improves symptoms such as loss of appetite and indigestion, thereby providing more nutrition to the body and supporting the absorption and utilization of other medicinal materials; Codonopsis pilosula has the following medicinal properties: neutral, and enters the spleen and lung meridians. Codonopsis pilosula can strengthen the spleen and stomach function by tonifying the middle and replenishing qi, and improve the body's overall immunity and resistance, thereby improving appetite and promoting digestion and absorption; Fried rice sprouts have the following medicinal properties: slightly warm, and enters the spleen and stomach meridians. Fried rice sprouts can improve symptoms such as indigestion and loss of appetite by their function of digesting food and eliminating accumulation, enhance gastrointestinal function, and improve the utilization rate of food; Jianqu has the following medicinal properties: warm, and enters the spleen and stomach meridians. Jianqu can relieve symptoms such as loss of appetite and indigestion by their function of strengthening the spleen and appetizing and promoting digestion, and improve the overall digestive system function.

[0028] The Chinese medicine composition can significantly improve the digestive function, enhance appetite, and increase the absorption efficiency of food and medicine for patients with symptoms of decreased appetite by adding Atractylodes macrocephala, Codonopsis pilosula, fried rice sprouts, and Jianqu to the Chinese medicine composition. The synergistic effect of these medicinal materials can not only promote the health of the digestive system, but also provide the body with sufficient nutrition, thereby enhancing the overall therapeutic effect and further improving the therapeutic effect of idiopathic oligospermia and asthenospermia.

[0029] The present invention is further configured as follows: for patients with symptoms of genital moisture, the Chinese medicine composition also includes Plantago seed, Atractylodes lancea, Coix seed, Phellodendron amurense, and Radix Dioscoreae.

[0030] By adopting the above technical scheme, the additionally added Plantago seeds of the present invention have the following properties: slightly cold, and enter the liver, kidney, lung, and small intestine meridians. Plantago seeds can help expel excess water from the body and reduce dampness and heat in the body through its diuretic and stranguria-relieving effects, thereby alleviating the symptoms of dampness in the genitals; Atractylodes macrocephala has the following properties: warm, and enters the spleen, stomach, and liver meridians. Atractylodes macrocephala can improve the state of spleen deficiency and dampness through its dampness-drying and spleen-strengthening effects, help regulate the spleen and stomach, promote the elimination of moisture in the body, and relieve dampness in the genitals; Coix seeds have the following properties: cool, and enter the spleen , stomach, and lung meridians. Coix seed can promote the discharge of excess water and moisture in the body through the effect of promoting diuresis and removing dampness, improve the damp-heat condition in the body, and relieve dampness in the genitals; Phellodendron chinense has the properties of cold, and it enters the kidney, bladder, and large intestine meridians. Phellodendron chinense can remove damp-heat toxins in the body through the effect of clearing heat and drying dampness, inhibit inflammation, and improve symptoms of dampness and discomfort in the genitals; Radix Dianthus radix has the properties of neutral, and it enters the kidney and bladder meridians. Radix Dianthus radix can remove dampness and turbidity in the body through the effect of promoting diuresis and removing turbidity, and improve symptoms of dampness in the genitals caused by damp-heat.

[0031] The present invention can significantly improve the damp-heat condition in the body of patients with symptoms of genital dampness by adding Plantago seed, Atractylodes lancea, Coix seed, Phellodendron amurense and Radix Dichroae to the traditional Chinese medicine composition. The synergistic effect of these medicinal materials can not only clear away heat and dampness, strengthen the spleen and remove dampness, but also enhance physical fitness and relieve the uncomfortable symptoms of genital dampness, thereby further improving the therapeutic effect of idiopathic oligospermia and asthenospermia and the overall health level of patients.

[0032] The present invention is further configured as follows: for patients with symptoms of semen liquefaction failure, the traditional Chinese medicine composition also includes earthworms, centipedes, leeches, and safflower.

[0033] By adopting the above technical scheme, the present invention additionally adds earthworm medicinal properties: cold in nature, salty in taste, and enters the liver, spleen, and bladder meridians. Earthworm helps liquefaction of semen and improves the symptoms of non-liquefaction of semen by promoting blood circulation and increasing enzyme activity; centipede medicinal properties: warm in nature, pungent in taste, and enters the liver meridian. It has the effects of calming wind and relieving spasm, attacking toxins and dispersing knots, and dredging meridians and relieving pain. Centipede helps improve the liquefaction state of semen and relieves the problem of non-liquefaction of semen by dredging meridians and relieving pain, and promoting local microcirculation; leech medicinal properties: flat in nature, salty and bitter in taste, and enters the liver meridian. Leech promotes blood flow through its effect of breaking blood and removing blood stasis, helps improve the liquefaction of semen, and relieves the symptoms of non-liquefaction of semen; safflower medicinal properties: warm in nature, pungent in taste, and enters the heart and liver meridians. Safflower promotes local blood circulation by activating blood circulation and dredging meridians, which helps improve the liquefaction state of semen and relieves the problem of non-liquefaction of semen;

[0034] The present invention can significantly improve the blood and qi conditions in patients with semen liquefaction symptoms by adding earthworms, centipedes, leeches and safflower to the traditional Chinese medicine composition. The synergistic effect of these medicinal materials can not only promote blood circulation and remove blood stasis, dredge meridians and relieve pain, but also strengthen physical fitness and promote normal liquefaction of semen, thereby further improving the treatment effect of idiopathic oligospermia and asthenospermia and the overall health level of patients.

[0035] The present invention is further configured as follows: for patients with symptoms of dry mouth and bitter taste, the traditional Chinese medicine composition also includes gardenia, oriental water chestnuts, capillaries, and scutellaria.

[0036] By adopting the above technical scheme, the additionally added gardenia of the present invention has the following properties: cold in nature, bitter in taste, and enters the heart, lung, and triple burner meridians; gardenia helps to eliminate waste heat and toxins in the body by clearing away heat and purging fire, and relieves the symptoms of dry mouth and bitter mouth caused by internal heat; the medicinal properties of oriental radix somatis are cold in nature, sweet and light in taste, and enter the kidney and bladder meridians; oriental radix somatis promotes water metabolism and the discharge of damp heat in the body by promoting diuresis and infiltration of dampness, and improves the symptoms of dry mouth and bitter mouth caused by damp heat stagnation; the medicinal properties of capillaris are slightly cold in nature, bitter in taste, and enter the spleen, stomach, liver, and gallbladder meridians; capillaris protects the liver by clearing away heat and dampness, accelerates the discharge of damp heat in the body, and improves the dry mouth and bitter mouth caused by internal damp heat; the medicinal properties of scutellaria baicalensis are cold in nature, bitter in taste, and enter the lung, liver, gallbladder, and large intestine meridians; scutellaria baicalensis reduces internal heat and dampness by clearing away heat and dampness, detoxifying and anti-inflammatory, and relieves the dry mouth and bitter mouth caused by damp heat accumulation;

[0037] The present invention can significantly improve the damp-heat condition in the body of patients with symptoms of dry mouth and bitter taste in the mouth by adding gardenia, oriental water chestnut, capillaris and scutellaria to the traditional Chinese medicine composition. The synergistic effect of these medicinal materials can not only clear away heat and dampness and regulate the internal environment, but also protect the liver, strengthen the physical fitness, and relieve the uncomfortable symptoms of dry mouth and bitter taste in the mouth, thereby further improving the overall health level and quality of life of the patients.

[0038] The present invention is further configured as follows: for patients with symptoms of oral ulcers, the Chinese medicine composition also includes coptis root, bamboo shavings, and lophatherum gracile.

[0039] By adopting the above technical scheme, the additionally added coptis root has the following properties: cold in nature, bitter in taste, and enters the heart, liver, stomach, and large intestine meridians. Coptis root can clear away heat and dampness, purge fire and detoxify, help eliminate fire toxicity and damp heat in the body, and relieve the symptoms of oral sores; bamboo shavings have the following properties: slightly cold in nature, sweet in taste, and enter the stomach and gallbladder meridians. Bamboo shavings can clear away heat and resolve phlegm, reduce fire and relieve restlessness, and relieve the symptoms of oral sores caused by fire and heat disturbance; light bamboo leaf has the following properties: cold in nature, sweet and light in taste, and enters the heart, stomach, and small intestine meridians. Light bamboo leaf can clear away heat and relieve restlessness, promote diuresis and remove dampness, help eliminate heat toxicity and damp heat in the body, and relieve the symptoms of oral sores;

[0040] The present invention can significantly improve the heat and damp-heat conditions in the body of patients with symptoms of oral sores by adding coptis chinensis, bamboo shavings and loblolly leaves to the traditional Chinese medicine composition. The synergistic effect of these medicinal materials can not only clear away heat and detoxify, dry dampness and relieve restlessness, but also strengthen the physical constitution and alleviate the uncomfortable symptoms of oral sores, thereby further improving the overall health level and quality of life of the patients.

[0041] The present invention is further configured as follows: for patients with symptoms of kidney yin deficiency, the Chinese medicine composition also includes raw rehmannia, cooked rehmannia, turtle shell, and cornus officinalis.

[0042] By adopting the above technical scheme, the raw rehmannia added in the present invention has the following medicinal properties: cold in nature, sweet and bitter in taste, and enters the heart, liver, and kidney meridians. The raw rehmannia nourishes yin and produces body fluid, clears heat and cools blood, helps replenish the yin fluid in the body, and relieves the heat symptoms caused by kidney yin deficiency, such as hot flashes, night sweats, dry mouth and throat, etc.; the cooked rehmannia has the following medicinal properties: warm in nature, sweet in taste, and enters the liver and kidney meridians. It has the effects of nourishing blood and yin, replenishing essence and filling marrow. The cooked rehmannia nourishes blood and yin, replenishes essence and fills marrow, enhances kidney yin function, and improves the symptoms of soreness of waist and knees, tinnitus, etc. caused by kidney yin deficiency; the turtle shell has the following medicinal properties: slightly cold in nature, salty in taste, and enters the liver and kidney meridians. The turtle shell nourishes yin and suppresses yang, softens and disperses nodules, helps replenish the yin fluid in the body, balances the yin and yang in the body, and relieves the symptoms of deficiency heat caused by kidney yin deficiency; the cornus has the following medicinal properties: slightly warm in nature, sour and astringent in taste, and enters the liver and kidney meridians. The cornus nourishes the liver and kidney, astringes the essence and helps replenish the yin of the liver and kidney, and improves the symptoms of spermatorrhea and night sweats caused by kidney yin deficiency;

[0043] The present invention can significantly improve the yin deficiency condition in patients with symptoms of kidney yin deficiency by adding raw rehmannia, cooked rehmannia, turtle shell and cornus officinalis to the traditional Chinese medicine composition. The synergistic effect of these medicinal materials can not only nourish yin and blood, nourish the kidney and improve essence, but also balance the yin and yang in the body, alleviate various discomfort symptoms caused by kidney yin deficiency, thereby further improving the overall health level and quality of life of the patients.

[0044] The present invention is further configured as follows: for patients with the bitter symptoms of premature ejaculation, the traditional Chinese medicine composition also includes Alpinia oxyphylla, Euryale ferox, Cynomorium songaricum, Dauci draco, and Oyster shell.

[0045] By adopting the above technical scheme, the additionally added Alpinia oxyphylla of the present invention has the following properties: warm in nature, pungent in taste, and enters the spleen and kidney meridians. It has the effects of warming the spleen and kidney, consolidating essence and reducing urine. Alpinia oxyphylla warms and tonifies the spleen and kidney, consolidating essence and reducing urine, and improves the symptoms of premature ejaculation caused by insufficient kidney qi; Euryale ferox medicinal properties: neutral in nature, sweet and astringent in taste, enters the spleen and kidney meridians, Euryale ferox helps to strengthen spleen and kidney function by tonifying the kidney and consolidating essence, strengthening the spleen and stopping diarrhea, and relieves the problem of premature ejaculation caused by kidney deficiency; Cynomorium songaricum medicinal properties: warm in nature, sweet in taste, enters the liver, kidney, and large intestine meridians, Cynomorium songaricum strengthens kidney yang, benefits essence and blood, strengthens kidney function, and improves the symptoms of premature ejaculation; Forged dragon bone medicinal properties: neutral in nature, sweet and astringent in taste, enters the heart, liver, and kidney meridians, Forged dragon bone helps to reduce kidney qi leakage by astringing and consolidating, calming and tranquilizing the mind, and relieves the problem of premature ejaculation; Forged oyster medicinal properties: slightly cold in nature, salty in taste, enters the liver and kidney meridians, Forged oyster helps to strengthen kidney qi by astringing and consolidating, tonifying the liver and kidney, and relieves the symptoms of premature ejaculation;

[0046] The present invention can significantly improve the kidney deficiency condition in patients with premature ejaculation symptoms by adding Alpinia oxyphylla, Euryale ferox, Cynomorium songaricum, Dracaena draco and Concha ostreae into the traditional Chinese medicine composition. The synergistic effect of these medicinal materials can not only tonify the kidney and consolidate the essence, and benefit the essence and blood, but also can astringe and consolidate, and relieve the uncomfortable symptoms of premature ejaculation caused by insufficient kidney qi, thereby further improving the overall health level and quality of life of the patients.

[0047] In summary, the present invention has the following beneficial effects:

[0048] 1. The present invention uses scientific compatibility of medicinal materials. The Chinese medicine composition of the present invention can comprehensively regulate the patient's body and comprehensively treat the cause of idiopathic oligospermia and asthenospermia. It can not only improve the number and quality of sperm, but also improve the overall health of the patient. It has significant clinical efficacy and high safety. This Chinese medicine composition provides an effective treatment option for patients and helps to improve reproductive health and quality of life.

[0049] 2. The present invention treats according to syndrome differentiation, and appropriately adds or subtracts corresponding drugs for those who have reduced appropriate diet, damp genitals, emotional distress, semen liquefaction, dry mouth and bitter taste, mouth and tongue ulcers, kidney yin deficiency, and premature ejaculation. DETAILED DESCRIPTION

[0050] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments.

[0051] Example 1: A Chinese medicine composition for treating idiopathic oligospermia and asthenospermia, weighing the following raw medicinal materials by weight: 45g of pilose antler, 45g of seahorse, 60g of ginseng, 30g of Cistanche, 20g of Epimedium, 20g of Schisandra, 40g of Cuscuta, 30g of Lycium barbarum, 10g of Psoralea corylifolia, 15g of tangerine peel, and 10g of cuttlebone, a total of 325g.

[0052] Example 2: On the basis of the Chinese medicine combination obtained in Example 1, according to syndrome differentiation and treatment, for those with reduced appropriate diet: add Atractylodes macrocephala, Codonopsis pilosula, fried rice sprouts, and Jianqu; for those with damp genitals: add Plantago seed, Atractylodes lancea, Coix seed, Phellodendron chinense, and Radix Dianthus; for those with emotional distress: add Curcuma aromatica, Bupleurum chinense, White Peony Root, and Cyperus rotundus; for those with semen liquefaction: add Earthworm, Scolopendra, Leech, and Carthami; for those with dry mouth and bitter taste: add Gardenia jasminoides, Alisma orientalis, Artemisia capillaris, and Scutellaria baicalensis; for those with mouth and tongue ulcers: Coptis chinensis, Rhizoma Anemarrhenae, and Lophatherum gracile; for those with kidney yin deficiency: soreness and weakness in the waist and knees, add Radix Rehmanniae glutinosae, Radix Rehmanniae glutinosae, Carapax trichosanthis, and Fructus Corni; for those with premature ejaculation: add Alpinia oxyphylla, Euryale ferox, Cynomorium songaricum, Forged Dragon Bone, and Forged Oyster.

[0053] Preparation method:

[0054] Treatment of medicinal materials: Wash all medicinal materials separately, remove impurities, dry them and set aside. For harder medicinal materials, such as deer antlers and seahorses, they can be crushed first to facilitate subsequent pill making;

[0055] Grinding of medicinal materials: Grind the dried medicinal materials separately until they reach a fine powder state to ensure that the medicinal materials are fully mixed and evenly mixed;

[0056] Mixing of medicinal powder: Mix the crushed medicinal powder according to the proportion and stir well to ensure that the ingredients of each pill are consistent;

[0057] Preparation of pills: Add appropriate amount of honey or other molding agent to the evenly mixed powder, stir evenly until the powder can be kneaded into a ball, and roll the powder into pills. The size of each pill is about the size of a sycamore seed, about 3-5 mm in diameter, and about 10 pills weigh 1 gram;

[0058] Pill drying: Dry the rolled pills naturally in a cool and ventilated place, avoid direct sunlight. After drying, store them in a sealed container to prevent moisture and insects.

[0059] Usage and Dosage:

[0060] Take 40-50 pills each time, twice a day, that is, take 80-100 pills a day; it is recommended to take it once in the morning and evening, with warm water after meals to promote the absorption of the drug; taking it continuously for 3 months is a course of treatment, and the taking time and dosage can be adjusted according to the efficacy and doctor's advice; during the period of taking it, you should maintain a light diet and avoid spicy and greasy food to avoid affecting the efficacy of the drug; if you experience any discomfort, you should stop taking it immediately and consult a doctor. Pregnant women, breastfeeding women and those with severe liver and kidney dysfunction should take it under the guidance of a doctor.

[0061] Clinical trial example 1:

[0062] 1. Purpose of Clinical Trial

[0063] To clarify the therapeutic effect and safety of self-prepared Haima Shenrong Pills in idiopathic oligospermia and asthenospermia

[0064] (1) To analyze the effect of self-prepared Haima Shenrong Pill on improving semen parameters, sexual function, and serum sex hormone levels in patients with idiopathic oligospermia and asthenospermia;

[0065] (2) To analyze the adverse reactions of the self-prepared Haima Shenrong Pill.

[0066] 2. Source of cases:

[0067] A total of 60 adult patients with idiopathic oligospermia and asthenospermia who were admitted to our hospital from January 2024 to December 2024 were selected as the research subjects. The patients were randomly divided into a control group and a treatment group by random number table method, with 30 cases in each group. The control group received conventional clomiphene combined with vitamin E treatment, and the treatment group was treated with self-prepared Haima Shenrong Pills instead of clomiphene combined with vitamin E. The differences in semen parameters, semen apoptosis factors, sexual function, serum sex hormone levels before and after treatment between the two groups were compared, as well as the occurrence of adverse reactions during treatment between the two groups.

[0068] Inclusion criteria: ① meet the diagnostic criteria for idiopathic oligospermia and asthenospermia in the "Expert Consensus on Male Reproductive Genetics Examination"; ② normal reproductive system examination of the female; ③ first onset of the disease; ④ complete clinical data.

[0069] Exclusion criteria: ① Combined liver function disease; ② Congenital reproductive system abnormalities; ③ Allergy to clomiphene or the Chinese medicinal ingredients in the self-prepared prescription; ④ Combined heart and lung function abnormalities; ⑤ Yang-heat constitution; ⑥ Family disharmony and failure to follow doctor's advice.

[0070] Sample size calculation: The sample size calculation method of comparing the mean values ​​of the two groups was used, and the total sperm motility rate was selected as the main indicator of efficacy. According to the literature review, the total sperm motility rate of the control group was 33.42±5.13 after treatment. It is expected that the total sperm motility rate of the treatment group will increase by at least 5 percentage points. The bilateral α=0.05 is set, and the degree of confidence is 90%. The sample size N1=24 cases in each group was calculated using PASS15 software. Considering the 20% loss of follow-up and refusal to visit, the final required subjects in the experimental group and the control group are at least 30 cases each, and a total of at least 60 subjects will be included.

[0071] Grouping design: The patients were randomly divided into a control group and a treatment group using the random number table method, with 30 cases in each group.

[0072] 3. Treatment options

[0073] Control group: conventional treatment, including quitting smoking and drinking, changing unhealthy lifestyle, doing appropriate physical exercise, maintaining adequate sleep and good mood, arranging diet reasonably, and taking rich and sufficient amino acids. They were also given clomiphene citrate tablets (25 mg / time, once / day, orally, continuous medication for 25 days and then interrupted for 5 days) and vitamin E soft capsules (100 mg / time, twice / day, orally) for 3 consecutive months. Patients with combined prostatitis were given anti-infection treatment at the same time.

[0074] Treatment group: On the basis of the control group, clomiphene citrate tablets and vitamin E soft capsules were replaced, and self-made Haima Shenrong Pills were given for treatment: 45g of pilose antler, 45g of seahorse, 60g of ginseng, 30g of Cistanche, 20g of epimedium, 20g of Schisandra, 40g of Cuscuta, 30g of Lycium barbarum, 10g of Psoralea corylifolia, 15g of dried orange peel, and 10g of Cuttlebone were taken every month, totaling 325g. The pills were made by rolling, and the pills were as big as sycamore seeds, about 10 pills of 1g, and 40-50 pills were taken each time, twice a day, totaling 80-100 pills, for 3 consecutive months.

[0075] IV. Treatment Plan

[0076] (1) Comparison of semen parameters: Before and after treatment, abstinence was performed for 2-7 days. Semen was collected for routine examination (sperm count ≥ 200). If the standard was not met, semen was collected again after 1 hour. Semen quality was examined using an SCA-type fully automatic sperm quality analyzer, and sperm survival rate, semen volume, sperm density, total sperm motility, sperm forward motility, a-grade sperm rate, a+b-grade sperm rate, etc. were recorded. In addition, ELIAS was used to detect semen apoptosis factor (Caspase-3).

[0077] (2) Comparison of sexual function: Before and after treatment, erectile function was assessed using the International Index of Erectile Function 5-item questionnaire (IIFE5)181, which includes 5 items related to sexual function (erection confidence, erection duration, erection maintenance, dyspareunia, and sexual satisfaction). Each item is scored from 0 to 5 points. A score of ≤21 points is considered to indicate erectile dysfunction, 17 to 21 points, 12 to 16 points, 8 to 11 points, and ≤7 points represent mild, mild to moderate, moderate, and severe erectile dysfunction, respectively. A score of ≥22 points is considered to indicate normal erectile function.

[0078] (3) Comparison of serum sex hormone levels: Fasting peripheral venous blood was collected from the patients before and after treatment, and the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), and prolactin (PRL) were measured using a Swiss Roche e601 fully automatic electrochemiluminescence analyzer.

[0079] (4) Comparison of adverse reactions: The incidence of allergic dermatitis, headache, stomachache, and insomnia in the two groups of patients during the 3-month treatment period was recorded. The total incidence rate = number of adverse reactions / total number of cases × 100%.

[0080] SPSS25.0 statistical software was used for statistical analysis. Count data were expressed as "n (%)", and chi-square test or Fisher's exact test were performed in parallel, with a bilateral α = 0.05 test level; measurement data that did not conform to normal distribution were expressed as median (interquartile range) "M (QR)", and Mann-Whitney U test was used for inter-group comparison. Measurement data that conformed to normal distribution were expressed as "mean ± sd", and paired sample t test was performed for intra-group comparison, and independent sample t test was used for inter-group comparison. The test level was bilateral α = 0.05. P < 0.05 was considered statistically significant.

[0081] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A Chinese medicine composition for treating idiopathic oligospermia and asthenospermia, characterized in that: The composition is a medicament prepared from the following raw materials by weight: 40-50g of pilose antler, 40-50g of seahorse, 50-70g of ginseng, 20-40g of cistanche, 10-30g of epimedium, 10-30g of schisandra chinensis, 30-50g of dodder seed, 20-40g of wolfberry, 5-15g of psoralea corylifolia, 10-20g of tangerine peel and 5-15g of cuttlebone.

2. A Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 2, characterized in that: The composition is a medicament prepared from the following raw materials by weight: 45g of pilose antler, 45g of seahorse, 60g of ginseng, 30g of cistanche, 20g of epimedium, 20g of schisandra, 40g of dodder seed, 30g of wolfberry, 10g of psoralea corylifolia, 15g of tangerine peel and 10g of cuttlebone.

3. The Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of decreased appetite, the Chinese medicine composition also includes Atractylodes macrocephala, Codonopsis pilosula, fried rice sprouts, and Jianqu.

4. The Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of genital dampness, the Chinese medicine composition also includes Plantago seed, Atractylodes lancea, Coix seed, Phellodendron amurense, and Radix Dioscoreae.

5. The Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of emotional distress, the Chinese medicine composition also includes Curcuma, Bupleurum, White Peony Root, and Cyperus rotundus.

6. The Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of semen liquefaction, the Chinese medicine composition also includes earthworms, centipedes, leeches and safflower.

7. The Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of dry mouth and bitter taste, the Chinese medicine composition also includes Gardenia, Alisma, Capillaris, and Scutellaria.

8. A Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of oral ulcers, the Chinese medicine composition also includes Coptis chinensis, Rhizoma Anemarrhenae, and Lophatherum gracile.

9. A Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with symptoms of kidney yin deficiency, the Chinese medicine composition also includes raw rehmannia, cooked rehmannia, turtle shell, and cornus officinalis.

10. A Chinese medicine composition for treating idiopathic oligospermia and asthenospermia according to claim 1, characterized in that: For patients with the bitter symptoms of premature ejaculation, the Chinese medicine composition also includes Alpinia oxyphylla, Euryale ferox, Cynomorium songaricum, Forged dragon bone, and Forged oyster.