A method for dispensing bags and bags for dispensing

Abstract

This invention provides a method for filling a continuous bag-type dispensing bag and the bag itself, relating to the field of biological agent dispensing technology. The method includes introducing cell fluid into the bag through a second connecting portion, filling each bag from bottom to top; stopping the introduction of cell fluid when the bag at the beginning is determined to be full; and heat-sealing the beginning and end of each bag using a heat sealer to ensure each bag contains a predetermined volume of cell fluid. By employing a serially designed continuous bag-type dispensing bag for storing cell fluid and introducing it from bottom to top, air bubbles are vented, enabling precise formulation with the smallest unit volume. This eliminates the need for manual formulation in a sterile environment, meeting the high requirements of precision formulation, providing portable dispensing, and effectively reducing labor costs.

Description

Technical Field

[0001] This invention relates to the field of biological agent packaging technology, and in particular to a packaging method for a continuous bag packaging bag and the continuous bag packaging bag itself. Background Technology

[0002] Currently, the repackaging of biological agents is an important component of the biomedical technology field, and is crucial for cell therapy and pharmaceutical preparation. During the repackaging of cell preparations, because processed cells are extremely scarce, high precision is required. Furthermore, given the small minimum unit volume of the preparation, current technologies typically involve manual repackaging in a sterile environment, which makes it susceptible to contamination and complicates the repackaging process. Summary of the Invention

[0003] This invention provides a method for dispensing from a continuous bag, which solves the problems of low dispensing accuracy and easy contamination in existing dispensing technologies.

[0004] This invention provides a method for packaging a continuous bag into individual packaging units, comprising:

[0005] Cell fluid is introduced into the interior of the continuous bag through the second connecting part, so that the cell fluid fills each bag from bottom to top;

[0006] Stop infusing cell fluid once the bag at the head is confirmed to be full of cell fluid.

[0007] The beginning and end of each bag are heat-sealed using a heat sealer so that each bag contains a predetermined volume of cell fluid.

[0008] According to an embodiment of the present invention, a method for dispensing a continuous bag is provided, wherein the outlet of the drip chamber is connected to the second connecting part through a first pipe, and before the step of introducing cell fluid into the continuous bag through the second connecting part, the method further includes:

[0009] The dripping funnel is driven to rotate so that the height of the dripping funnel inlet is greater than the height of the dripping funnel outlet, thereby allowing the cell fluid in the dripping funnel to be input into the interior of the bag-type dispensing bag through the second connecting part.

[0010] According to an embodiment of the present invention, a method for dispensing a continuous bag into a dispensing container further includes, prior to the step of driving the dripping funnel to rotate:

[0011] The cell fluid is fed into the dropper to remove air bubbles.

[0012] According to an embodiment of the present invention, a method for dispensing cells using a continuous bag includes a first connecting portion equipped with a bubble sensor or a light sensor; the step of stopping the infusion of cell fluid when it is determined that the bag located at the head portion is full includes:

[0013] When the bubble sensor or the light sensor detects the flow of cell fluid, the pump body is controlled to stop pumping cell fluid into the bag-type dispensing bag.

[0014] According to an embodiment of the present invention, a method for dispensing via a continuous bag is provided, wherein a pressure sensor or a flow sensor is connected in series in the first pipeline; the step of stopping the infusion of cell fluid when it is determined that the bag located at the head is full includes:

[0015] When the pressure in the first pipeline is greater than or equal to a preset pressure value, or when the flow rate in the first pipeline is greater than or equal to a preset flow rate, the pump body is controlled to stop pumping cell fluid into the bag-type dispensing bag.

[0016] According to an embodiment of the present invention, a method for dispensing via a continuous bag is provided, wherein the continuous bag is connected to a weighing sensor, and the step of stopping the infusion of cell fluid when it is determined that the bag located at the head is full of cell fluid includes:

[0017] The weight of the cell solution inside the bag is determined based on the weight of the bag and the total weight of the bag after the cell solution is introduced.

[0018] The volume of cell fluid in the bagged dispensing bag is determined based on the weight of the cell fluid inside the bagged dispensing bag.

[0019] When the volume of cell fluid in the connected bag is greater than or equal to the preset volume, the pump body is controlled to stop pumping cell fluid into the connected bag.

[0020] According to an embodiment of the present invention, a continuous bag for repackaging is provided, wherein the continuous bag for repackaging is based on a repackaging method for the continuous bag for repackaging described in any one of the above embodiments, comprising:

[0021] Multiple bags are connected end to end in sequence. The connection between two adjacent bags forms a connecting channel for connecting the two adjacent bags. The first bag is provided with a first connecting part, and the bag at the end is provided with a second connecting part.

[0022] According to an embodiment of the present invention, a multi-bag packaging bag is provided, wherein each bag has an equal capacity.

[0023] According to an embodiment of the present invention, a multi-bag packaging bag is provided in which the cross-section of the first end of each bag gradually decreases along a first direction, and the cross-section of the tail end of each bag gradually decreases along a second direction.

[0024] According to an embodiment of the present invention, a continuous bag for dispensing is provided, wherein the first connecting part is used to communicate with a sterile filter, and the second connecting part is used to communicate with the liquid outlet of a dripping funnel or the liquid outlet of an air bubble removal container through a first pipeline.

[0025] The dispensing method of the continuous bag dispensing bag provided in this embodiment of the invention uses a serially designed continuous bag dispensing bag to store cell fluid and introduces cell fluid into the bag from bottom to top, which realizes the air bubble removal process, can achieve precise preparation of the smallest unit volume, eliminates the need for artificial preparation in a sterile environment, meets the high requirements of precision preparation, has the effect of portable dispensing, and effectively reduces labor costs. Attached Figure Description

[0026] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0027] Figure 1 This is one of the flowcharts illustrating the packaging method of the continuous bag packaging bag provided in the embodiments of the present invention;

[0028] Figure 2 This is a second schematic flowchart of the dispensing method for the continuous bag dispensing bag provided in the embodiment of the present invention;

[0029] Figure 3 This is the third flowchart illustrating the method for dispensing a continuous bag according to an embodiment of the present invention;

[0030] Figure 4 This is the fourth flowchart illustrating the method for dispensing a continuous bag for dispensing provided in this embodiment of the invention.

[0031] Figure 5 This is a side view cross-sectional structural diagram of the continuous bag packaging bag provided in an embodiment of the present invention.

[0032] Reference numerals: 100, connecting bag for repackaging; 110, bag body; 120, connecting channel; 130, first end; 140, last end; 150, first connecting part; 160, second connecting part. Detailed Implementation

[0033] The embodiments of the present invention will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of the invention.

[0034] In the description of the embodiments of the present invention, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of the present invention. In addition, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0035] In the description of the embodiments of the present invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of the present invention based on the specific circumstances.

[0036] In embodiments of the present invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0037] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0038] Figure 1 This example illustrates one of the flowcharts of a method for dispensing a multi-bag packaging bag provided in an embodiment of the present invention, such as... Figure 1As shown, the packaging method for multi-bag repackaging includes the following steps:

[0039] In step S100, cell fluid is introduced into the interior of the bag-filling bag 100 through the second connecting part 160 so that the cell fluid fills each bag 110 from bottom to top;

[0040] The cell solution is introduced by a pump (not shown), which is connected in series with the first conduit, specifically between the outlet of the drip chamber (not shown) and the second connection 160. When the pump operates, it compresses the first conduit, and under pressure, the cell solution is introduced into the connected bag 100. During the continuous introduction of cell solution into the connected bag 100, the connected bag 100 must remain vertical (it can be fixed by hanging vertically). At this time, the second connection 160 is located at the bottom of the connected bag 100, and the first connection 150 is located at the top. During the cell solution introduction process, the cell solution fills each bag 110 from bottom to top, and air bubbles rise and are discharged through the first connection 150 during filling, ensuring that there are no air bubbles inside the connected bag 100 throughout the entire formulation process.

[0041] Furthermore, in order to ensure better drainage of the cell fluid, during the process of introducing the cell fluid into the bag 100, it is necessary to ensure a stable flow rate of the introduced cell fluid so that the rising cell fluid can expel air from any point inside the bag 100.

[0042] It should be noted that the pump body in this embodiment is a peristaltic pump, but of course, the pump body can also be other types of pump bodies.

[0043] Step S200: Stop the infusion of cell fluid when it is confirmed that the bag 110 at the head is full of cell fluid;

[0044] In step S300, the first end 130 and the last end 140 of each bag 110 are heat-sealed using a heat sealer so that each bag 110 contains a predetermined volume of cell fluid.

[0045] Since the capacity of each bag 110 is fixed, after heat-sealing the first end 130 and the last end 140 of each bag 110, the capacity of cell fluid in each bag 110 is also fixed, thus obtaining a cell preparation bag of the required capacity.

[0046] It should be noted that the capacity of each 110 bag can be designed according to specific needs, with the minimum capacity being less than 10ml.

[0047] The dispensing method of the continuous bag dispensing bag provided in this embodiment of the invention uses a serially designed continuous bag dispensing bag 100 to store cell fluid and introduces cell fluid into the bag body 110 in a bottom-up manner, which realizes the air bubble removal process, can achieve precise preparation of the smallest unit volume, does not require artificial preparation in a sterile environment, meets the high requirements of precision preparation, has the effect of portable dispensing, and effectively reduces labor costs.

[0048] In one embodiment of the present invention, the first connecting portion 150 and the second connecting portion 160 of the continuous bag dispensing bag 100 are both connecting pipes. Specifically, the first connecting portion 150 is a liquid outlet connecting pipe, and the second connecting portion 160 is a liquid inlet connecting pipe. Of course, the first connecting portion 150 and the second connecting portion 160 can also be in the form of connecting ports. Specifically, the first connecting portion 150 is the connecting outlet of the continuous bag dispensing bag 100, and the second connecting portion 160 is the connecting inlet of the continuous bag dispensing bag 100. Providing connecting portions facilitates the connection of the continuous bag dispensing bag 100 to the pipeline. Specifically, the first connecting portion 150 is used to communicate with a sterile filter, and the second connecting portion 160 is used to communicate with the liquid outlet of a dripping funnel or the liquid outlet of an air bubble removal container through a first pipeline.

[0049] In an embodiment of the present invention, the outlet of the drip chamber is connected to the second connecting part 160 through a first pipe. Before the step of introducing cell fluid into the inside of the bag-type dispensing bag 100 through the second connecting part 160, the dispensing method of the bag-type dispensing bag further includes:

[0050] The dropper is driven to rotate so that the height of the dropper inlet is greater than the height of the dropper outlet, thereby allowing the cell fluid in the dropper to be fed into the inner part of the bag-type dispensing bag 100 through the second connecting part 160.

[0051] The rotation of the dripping bucket is driven by a dripping bucket rotation assembly. The dripping bucket is snapped into the dripping bucket rotation assembly, which is electrically connected to a control unit. The control unit controls the rotation of the dripping bucket rotation assembly, thereby driving the rotation of the dripping bucket. The control unit can be a control circuit board, a controller, or a PLC. The dripping bucket rotation assembly is a commonly used component in the field of biopharmaceutical dispensing technology; therefore, its specific structure will not be described in detail here.

[0052] After the dropper is rotated, the height of the dropper inlet is greater than the height of the dropper outlet. At this time, cell fluid is continuously fed into the dropper. Under internal pressure, the cell fluid at the dropper outlet pushes the cell fluid in the first tubing through the second connector 160 into the interior of the connected bag 100. Since the connected bag 100 is in a vertical position, after the cell fluid is pushed into the connected bag 100 through the second connector 160, the air inside the connected bag 100 moves upward under the pushing force of the cell fluid and is eventually discharged through the sterile filter. The sterile filter prevents bacteria-laden air from entering the interior of the connected bag 100, thus avoiding contamination of the cell fluid inside the connected bag 100.

[0053] In an embodiment of the present invention, prior to the step of driving the dripping bucket to rotate, the dispensing method of the continuous bag dispensing bag further includes:

[0054] The cell solution was fed into a dropper to remove air bubbles.

[0055] Before introducing the cell culture into the bag-type dispensing bag 100, the cell culture is introduced into a dropper for degassing to prevent air bubbles from remaining in the cell culture and tubing. For better degassing, the dropper can be placed vertically, with the cell culture flowing into it from below. After a small amount of liquid flows in, air bubbles in the tubing are removed, and the bubbles rise and are expelled from the dropper.

[0056] In an embodiment of the present invention, the first connecting part 150 is provided with a bubble sensor or a light sensor, which is electrically connected to the control unit.

[0057] The steps to stop the infusion of cell fluid once the bag 110 at the head is confirmed to be full include:

[0058] When the bubble sensor or light sensor detects the flow of cell fluid, the pump body is controlled to stop pumping cell fluid into the bag 100.

[0059] The bubble sensor or light sensor is electrically connected to the control unit, and the control unit is electrically connected to the pump body. When the dispensing bag 100 is filled with cell fluid, the cell fluid enters the first connecting part 150. At this time, when the bubble sensor or light sensor detects the flow of cell fluid, it outputs an electrical signal to the control unit, indicating that the dispensing bag 100 is full of cell fluid. The control unit recognizes the electrical signal and controls the pump body to stop working, and the pump body stops pumping cell fluid into the dispensing bag 100.

[0060] In an embodiment of the present invention, a pressure sensor or a flow sensor is connected in series in the first pipeline; the step of stopping the infusion of cell fluid when it is determined that the bag 110 located at the head is full of cell fluid includes:

[0061] When the pressure in the first pipeline is greater than or equal to the preset pressure value, or when the flow rate in the first pipeline is greater than or equal to the preset flow rate, the pump body is controlled to stop pumping cell fluid into the bag-type dispensing bag 100.

[0062] A pressure sensor or flow sensor is electrically connected to the control unit. The pressure sensor detects the pressure in the first pipeline. Since the dispensing bag 100 is vertically positioned, the pressure in the first pipeline is related to the volume of cell fluid in the dispensing bag 100. Specifically, the higher the cell fluid rises in the dispensing bag 100, the greater the pressure in the first pipeline. The control unit acquires the pressure value detected by the pressure sensor in real time and compares it with a preset pressure value. When the pressure value in the first pipeline is greater than or equal to the preset pressure value, it indicates that the dispensing bag 100 is full of cell fluid. The control unit then controls the pump to stop working, and the pump stops pumping cell fluid into the dispensing bag 100.

[0063] It should be noted that the pressure sensor is not only installed in the first pipeline, but can also be installed in the second connection part.

[0064] A flow sensor is used to detect the flow rate of cell fluid in the first pipeline. Given that the model of the dispensing bag 100 is known, its capacity is also known. Therefore, by detecting the flow rate of cell fluid through the first pipeline using the flow sensor, the volume of cell fluid in the dispensing bag 100 can be calculated. When the flow rate in the first pipeline is greater than or equal to a preset flow rate, it indicates that the dispensing bag 100 is full of cell fluid. The control unit then stops the pump, halting the pumping of cell fluid into the dispensing bag 100.

[0065] It should be noted that the flow sensor is not only installed in the first pipeline, but can also be installed in the second connection part.

[0066] In an embodiment of the present invention, the continuous bag 100 is connected to a weighing sensor, and the step of stopping the infusion of cell fluid when it is determined that the bag 110 at the head is full of cell fluid includes:

[0067] The weight of the cell solution inside the bag-and-packet 100 is determined based on the weight of the bag-and-packet 100 and the total weight of the bag-and-packet 100 after the cell solution has been introduced.

[0068] The weighing sensor is connected to the bag 100. To facilitate fixing the bag 100, a hanging part is provided on the bag 100. The weighing sensor is connected to the hanging part. The hanging part can be a through hole or a hanging ring.

[0069] Before the cell solution is added to the dispensing bag 100, the weight detected by the weighing sensor is the weight of the dispensing bag 100. Of course, if the specifications of the dispensing bag 100 are known, its weight is also known and can be used as a known value. As the cell solution is continuously added to the dispensing bag 100, the weight detected by the weighing sensor increases with the increase in the volume of the cell solution. At this point, the weight detected by the weighing sensor is the total weight of the dispensing bag 100 after the cell solution has been added, that is, the sum of the weight of the cell solution and the weight of the dispensing bag 100. By subtracting the weight of the dispensing bag 100 from the total weight after the cell solution has been added, the weight of the cell solution inside the dispensing bag 100 can be obtained.

[0070] The volume of cell fluid in the bag-in-bag 100 is determined based on the weight of the cell fluid inside the bag-in-bag 100.

[0071] Since the density of the cell sap is known, the volume of the cell sap in the bagged dispensing bag 100 can be calculated after obtaining the weight of the cell sap in the bagged dispensing bag 100.

[0072] When the volume of cell fluid in the bagged dispensing bag 100 is greater than or equal to the preset volume, the pump body is controlled to stop pumping cell fluid into the bagged dispensing bag 100.

[0073] When the volume of cell fluid in the bagged dispensing bag 100 is greater than or equal to the preset volume, it indicates that the bagged dispensing bag 100 is full of cell fluid. The control unit then controls the pump to stop working, and the pump stops pumping cell fluid into the bagged dispensing bag 100.

[0074] In an embodiment of the present invention, after the step of heat-sealing the first end 130 and the last end 140 of each bag 110 using a heat-sealing device, the method for dispensing the continuous bag further includes:

[0075] Place the 100 bags into the freezing equipment for freezing;

[0076] By placing the bag-and-filler 100 into a cryopreservation device for freezing, the cell characteristics of the cell fluid can be preserved, and the frozen bag-and-filler 100 can be kept for later use.

[0077] The following is combined with Figure 2 A specific embodiment of the present invention is described below. Figure 2 This is a second example of a flowchart illustrating the dispensing method for the continuous bag packaging provided in an embodiment of the present invention. Figure 2 As shown, the packaging method for multi-bag repackaging includes:

[0078] Step S100: The cell solution is fed into a dropper to remove air bubbles;

[0079] Step S200: Drive the dropper to rotate so that the height of the dropper inlet is greater than the height of the dropper outlet, thereby allowing the cell fluid in the dropper to be fed into the inside of the bag-type dispensing bag 100 through the second connecting part 160.

[0080] In step S300, cell fluid is introduced into the interior of the bag-filling bag 100 through the second connecting part 160 so that the cell fluid fills each bag 110 from bottom to top;

[0081] Step S400: When the bubble sensor or light sensor detects the flow of cell fluid, control the pump to stop pumping cell fluid into the bag 100.

[0082] In step S500, the first end 130 and the last end 140 of each bag 110 are heat-sealed using a heat sealer so that each bag 110 contains a predetermined volume of cell fluid.

[0083] Step S600: Place the bagged packaging bag 100 into the freezing equipment for freezing.

[0084] The following is combined with Figure 3 A specific embodiment of the present invention is described below. Figure 3 This is illustrated in the third flowchart of the dispensing method for the continuous bag dispensing bag provided in this embodiment of the invention. Figure 3 As shown, the packaging method for multi-bag repackaging includes:

[0085] Step S100: The cell solution is fed into a dropper to remove air bubbles;

[0086] Step S200: Drive the dropper to rotate so that the height of the dropper inlet is greater than the height of the dropper outlet, thereby allowing the cell fluid in the dropper to be fed into the inside of the bag-type dispensing bag 100 through the second connecting part 160.

[0087] In step S300, cell fluid is introduced into the interior of the bag-filling bag 100 through the second connecting part 160 so that the cell fluid fills each bag 110 from bottom to top;

[0088] Step S400: When the pressure of the first pipeline is greater than or equal to the preset pressure value, or when the flow rate of the first pipeline is greater than or equal to the preset flow rate, control the pump body to stop pumping cell fluid into the bag-type dispensing bag 100.

[0089] In step S500, the first end 130 and the last end 140 of each bag 110 are heat-sealed using a heat sealer so that each bag 110 contains a predetermined volume of cell fluid.

[0090] Step S600: Place the bagged packaging bag 100 into the freezing equipment for freezing.

[0091] The following is combined with Figure 4A specific embodiment of the present invention is described below. Figure 4 This is illustrated in the fourth flowchart of the dispensing method for the continuous bag dispensing bag provided in the embodiment of the present invention. Figure 4 As shown, the packaging method for multi-bag repackaging includes:

[0092] Step S100: The cell solution is fed into a dropper to remove air bubbles;

[0093] Step S200: Drive the dropper to rotate so that the height of the dropper inlet is greater than the height of the dropper outlet, thereby allowing the cell fluid in the dropper to be fed into the inside of the bag-type dispensing bag 100 through the second connecting part 160.

[0094] In step S300, cell fluid is introduced into the interior of the bag-filling bag 100 through the second connecting part 160 so that the cell fluid fills each bag 110 from bottom to top;

[0095] Step S400: Determine the weight of the cell solution in the bag-in-bag 100 based on the weight of the bag-in-bag 100 and the total weight of the bag-in-bag 100 after the cell solution has been introduced.

[0096] Step S500: Determine the volume of cell fluid in the bagged dispensing bag 100 based on the weight of the cell fluid in the bagged dispensing bag 100.

[0097] Step S600: When the cell fluid volume in the bag-in-bag dispensing bag 100 is greater than or equal to the preset volume, control the pump to stop pumping cell fluid into the bag-in-bag dispensing bag 100.

[0098] In step S700, the first end 130 and the last end 140 of each bag 110 are heat-sealed using a heat sealer so that each bag 110 contains a predetermined volume of cell fluid.

[0099] Step S800: Place the bagged packaging bag 100 into the freezing equipment for freezing.

[0100] The dispensing method of the continuous bag dispensing bag provided in this embodiment of the invention uses a serially designed continuous bag dispensing bag to store cell fluid and introduces cell fluid into the bag from bottom to top, which realizes the air bubble removal process, can achieve precise preparation of the smallest unit volume, eliminates the need for artificial preparation in a sterile environment, meets the high requirements of precision preparation, has the effect of portable dispensing, and effectively reduces labor costs.

[0101] Figure 5 A side view cross-sectional structural diagram of the continuous bag packaging bag provided in an embodiment of the present invention is illustrated, as follows: Figure 5As shown, a second aspect of the present invention also provides a continuous bag for dispensing. The continuous bag for dispensing is based on the dispensing method of the continuous bag for dispensing described in any of the above embodiments. The continuous bag for dispensing includes a plurality of bag bodies 110, which are connected end to end in sequence, that is, the first end 130 of the previous bag body 110 is connected to the last end 140 of the next bag body 110. A connecting channel 120 for connecting the two adjacent bag bodies 110 is formed at the connection point of the two adjacent bag bodies 110. A first connecting part 150 is provided at the first bag body 110 and is connected to the first bag body 110. A second connecting part 160 is provided at the last bag body 110 and is connected to the last bag body 110.

[0102] It should be noted that the connecting channel 120 between two adjacent bags 110 can have various structural forms. The connecting channel 120 can be a flow channel formed at the connection between two adjacent bags 110, or it can be a pipe set between two adjacent bags 110.

[0103] In embodiments of the present invention, each bag 110 has an equal capacity, so that after the head 130 and tail 140 of each bag 110 are heat-sealed, the cell fluid volume inside each bag 110 is equal. Of course, the capacity of the bags 110 can also be different; for example, some bags 110 may have a capacity of 10 ml, and others may have a capacity of 15 ml. This allows for the preparation of cell preparation bags of different specifications. When the capacities of the bags 110 are different and similar, it is difficult to determine the capacity of the bags 110 by observing their dimensions. For example, if some bags have a capacity of 11 ml and others have a capacity of 10 ml, it is difficult to directly determine the capacity of the bags 110 when they are mixed together. To facilitate the determination of the capacity of the bags 110, markings can be provided on the surface of the bags 110 for identification. These markings can be numbers or symbols of different colors.

[0104] In embodiments of the present invention, multiple bag bodies 110 are aligned on a straight line, and multiple connecting channels 120 are also aligned on a straight line. Each bag body 110 has the same shape. The cross-section of the beginning 130 of each bag body gradually decreases along a first direction, and the cross-section of the end 140 of each bag body gradually decreases along a second direction. The first direction is opposite to the second direction. The first direction refers to the direction from the end 140 to the beginning 130, and the second direction refers to the direction from the beginning 130 to the end 140. Figure 5As shown, the cross-section of the first end 130 of each bag 110 gradually decreases to the left, and the cross-section of the last end 140 of each bag 110 gradually decreases to the right. Because the cross-sections of the first end 130 and the last end 140 of each bag 110 gradually decrease in opposite directions, the connection between adjacent bags 110 contracts inwards; that is, the inner wall of the connection between adjacent bags 110 contracts inwards, forming a V-shaped connection structure. This V-shaped connection structure facilitates heat sealing of the bags 110, preventing misalignment of the heat-sealing position and thus avoiding deviations in the capacity of the bags 110.

[0105] It should be noted here that the cross-section of bag body 110 refers to the edge Figure 5 The cross-section made along the front and back directions of the middle, the longitudinal section of bag body 110 refers to the section along the front and back directions. Figure 5 The cross-section in the left-right direction.

[0106] Furthermore, in order to prevent deviation between the actual heat sealing position and the designed heat sealing position during the heat sealing process of the bag body 110, a marking line or marking area can be set at the connection between two adjacent bag bodies 110. During the heat sealing process of the bag body 110, as long as the heat sealing instrument is aligned with the marking line or marking area, the bag body 110 can be accurately packaged, thereby improving the packaging accuracy of the bag body 110.

[0107] In embodiments of the present invention, each bag 110 has the same cross-sectional shape and the same longitudinal cross-sectional shape. The longitudinal cross-sectional shape of the bag 110 can be rhomboid, spherical, regular hexagonal, or other shapes. Because the cross-section of the beginning 130 of each bag 110 gradually decreases, during the process of the cell fluid rising within the bag 100, air bubbles within the bag 110 have no place to hide and can only be pushed upwards by the cell fluid, ultimately being discharged through a sterile filter. Compared to bag 110s with a flat beginning 130, the bag 110 of the present invention has a better air venting effect.

[0108] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A method for packaging multi-bag packaging, characterized in that, include: Cell fluid is introduced into the interior of the connected bag (100) through the second connecting part (160) so that the cell fluid fills each bag (110) from bottom to top. The connected bag (100) is fixed by hanging vertically, and multiple bags (110) are connected end to end in sequence. Stop infusing cell fluid when it is determined that the bag (110) located at the head is full of cell fluid; The head (130) and tail (140) of each bag (110) are heat-sealed using a heat sealer so that each bag (110) contains a predetermined volume of cell fluid. The outlet of the dropper is connected to the second connecting part (160) via a first pipe. Before the step of introducing cell fluid into the inside of the bag-type dispensing bag (100) through the second connecting part (160), the method further includes: The dropper is driven to rotate so that the height of the dropper inlet is greater than the height of the dropper outlet, thereby allowing the cell fluid in the dropper to be input into the interior of the bag-type dispensing bag (100) through the second connecting part (160); Prior to the step of driving the dripping bucket to rotate, the method further includes: The cell fluid is fed into the dropper to remove air bubbles.

2. The method for packaging bags according to claim 1, characterized in that, The first connecting part is provided with a bubble sensor or a light sensor; the step of stopping the infusion of cell fluid when it is determined that the bag (110) located at the head is full of cell fluid includes: When the bubble sensor or the light sensor detects the flow of cell fluid, the pump body is controlled to stop pumping cell fluid into the bag-type dispensing bag (100).

3. The method for packaging bags according to claim 1, characterized in that, The first conduit is connected in series with a pressure sensor or a flow sensor; the step of stopping the infusion of cell fluid when it is determined that the bag (110) located at the head is full of cell fluid includes: When the pressure in the first pipeline is greater than or equal to the preset pressure value, or when the flow rate in the first pipeline is greater than or equal to the preset flow rate, the pump body is controlled to stop pumping cell fluid into the bag-type dispensing bag (100).

4. The method for packaging bags according to claim 1, characterized in that, The connected dispensing bag (100) is connected to a weighing sensor. The step of stopping the infusion of cell fluid when it is determined that the bag (110) at the head is full of cell fluid includes: The weight of the cell solution inside the bag-and-fill bag (100) is determined based on the weight of the bag-and-fill bag (100) and the total weight of the bag-and-fill bag (100) after the cell solution is introduced. The volume of cell fluid in the bagged dispensing bag (100) is determined based on the weight of the cell fluid in the bagged dispensing bag (100); When the cell fluid volume in the connected bag (100) is greater than or equal to the preset volume, the pump body is controlled to stop pumping cell fluid into the connected bag (100).

5. A continuous bag for repackaging (100), wherein the continuous bag for repackaging (100) is based on the repackaging method of the continuous bag for repackaging according to any one of claims 1 to 4, characterized in that, include: Multiple bags (110) are connected end to end in sequence. A connecting channel (120) is formed at the connection point of two adjacent bags (110) to connect the two adjacent bags (110). A first connecting part is provided at the first bag (110), and a second connecting part (160) is provided at the last bag (110). The cross-section of the first end (130) of each bag (110) gradually decreases along a first direction, and the cross-section of the tail end (140) of the bag (110) gradually decreases along a second direction; The first connecting part is used to communicate with a sterile filter, and the second connecting part (160) is used to communicate with the outlet of the dripping bucket or the outlet of the bubble removal container through the first pipeline.

6. The continuous bag packaging bag according to claim 5, characterized in that, Each of the bags (110) has the same capacity.

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