An ultra-slip anti-stick urinary catheter with a bionic drag-reducing structure

Abstract

The present application relates to the field of medical catheters, and specifically discloses an ultra-slip anti-adhesive urinary catheter with a bionic drag-reducing structure. The present application sets a multi-level bionic drag-reducing structure on the inner wall of the catheter body, including a wedge-shaped protrusion structure and a corrugated protrusion structure; wherein, the wedge-shaped protrusion structure array is arranged and adhered to the inner wall of the catheter body, and the corrugated protrusion structure array is arranged on the main inclined surface of the wedge-shaped protrusion unit; finally, a biocompatible hydrophobic polymer ultra-slip coating is grafted onto the inner and outer walls of the catheter at the same time. The present application achieves a multi-level synergistic anti-adhesive drag-reducing effect through a bionic anti-adhesive drag-reducing structure, reduces the adhesion of urine, stones, blood and bacteria to the inner wall of the catheter, reduces the probability of adhesion scaling, stone deposition and blockage infection caused by long-term immersion of the catheter in urine, effectively prolongs the retention time of the catheter, and at the same time reduces the risk of damage and infection to the patient during the use of the catheter through the hydrophobic ultra-slip coating, and increases the safety and convenience of long-term indwelling catheterization.

Description

Technical Field

[0001] The present application relates to the field of medical catheters, and in particular to an ultra-slip and anti-stick urinary catheter with a bionic drag-reducing structure. Background Art

[0002] For urinary incontinence and dysuria caused by physiological and medical factors, the placement of an indwelling urinary catheter remains the primary means of alleviating urinary dysfunction and is increasingly used clinically. However, this procedure is invasive, and the insertion and removal of the catheter can cause friction in the urethra, potentially damaging the patient's urethral mucosa and causing urinary tract infections. Furthermore, prolonged retention of a catheter deep in the bladder can lead to mineral salts in the urine crystallizing and potentially clogging the catheter.

[0003] Currently, some catheters with super-lubricating, hydrophilic coatings are available on the market. These super-lubricating, hydrophilic coatings, upon contact with water, form a hydrated, lubricating film between the catheter surface and the delicate urethral tissue. This reduces friction and irritation from the outer catheter wall to the urethral tissue, mitigating the risk of damage and infection. However, after a long-term indwelling catheter is placed deep into the bladder, the inner wall of the catheter becomes less hydrophobic and difficult to maintain over time. Furthermore, as urine flows through the catheter, the flow rate is faster in the center and slower closer to the inner wall. Closer to the inner wall, the flow rate approaches zero, making it easier for impurities in the urine to settle on the inner wall. This can lead to residual urine scaling, stone deposition, and bacterial adhesion to form a biofilm, which can easily lead to catheter obstruction and infection. Summary of the Invention

[0004] In order to improve the problems of adhesion, crystallization and blockage caused by long-term immersion of urine in a urinary catheter, the present application provides a bionic anti-viscosity and drag reduction structure for easily settling fluids and an ultra-slip anti-viscosity urinary catheter with a bionic drag reduction structure.

[0005] A bionic anti-viscosity drag reduction structure for easily settling fluids, comprising:

[0006] The wedge-shaped protrusion structure includes a plurality of wedge-shaped protrusion units arranged in an array and attached to the wall surface of the flow channel, each of the wedge-shaped protrusion units includes one or more main inclined surfaces inclined to the wall surface of the flow channel, and the main inclined surfaces face the flow direction of the fluid;

[0007] A corrugated protrusion structure comprising a plurality of corrugated protrusion units arranged in an array on the main inclined surface, wherein the sizes of the corrugated protrusion units and the wedge-shaped protrusion units are both in the micron order;

[0008] A hydrophobic super-slip coating is provided on the wall surface of the flow channel.

[0009] The bionic anti-adhesion and drag reduction structure provided in this application adopts a wedge-shaped protrusion structure that mimics the characteristics of tarpon scales and a corrugated protrusion structure that mimics the skirt of kelp. By combining the micron-scale bionic anti-adhesion and drag reduction structure with the nano-scale hydrophobic super-slip coating, synergistic anti-adhesion and drag reduction are achieved. The specific principles are as follows:

[0010] Grooves are formed between the micron-sized wedge-shaped protrusions, which are low in front and high in the back. When the fluid flows through the tail of the wedge-shaped protrusion, the fluid swirls to generate vortices, causing the part of the fluid near the wedge-shaped protrusion to generate a non-zero initial velocity, promptly washing away the settled impurities and viscous fluid, and reducing the viscous resistance inside the fluid. At the same time, the wedge-shaped protrusions, which are low in front and high in the back, keep the fluid at a high contact angle front. The micron-sized corrugated protrusion structure increases the roughness of the main inclined surface of the wedge-shaped protrusion. Combined with the hydrophobic coating, it further enhances the super-slip anti-stick properties, reduces the thickness of the fluid boundary layer, and reduces the direct contact and adhesion of the fluid and impurities with the channel wall, thereby reducing the frictional resistance between the fluid and the wall. This not only reduces the residual, adhesion or backflow of the fluid on the channel wall, achieving anti-stick drag reduction when the fluid and impurities contact the channel wall, but also reduces viscous friction, thereby reducing the energy loss of the fluid vortex, which is conducive to maintaining a stable fluid vortex and further enhancing the anti-stick effect.

[0011] Furthermore, the angle between the main inclined surface and the flow channel wall is less than 10°.

[0012] Furthermore, the wedge-shaped protrusion unit further includes a wall-adhering surface adhered to the wall surface of the flow channel, and the shape of the wall-adhering surface includes one or a combination of polygonal, circular, elliptical or fan-shaped.

[0013] Preferably, the polygonal shape of the wall-adhering surface includes any one of a triangle, a quadrilateral, and a pentagon, or a combination of several of them.

[0014] Furthermore, a plurality of the wedge-shaped protrusion units form a planar array on the wall surface of the flow channel, and the arrangement of the array includes any one or a combination of square, rhombus, hexagonal and irregular arrays.

[0015] Furthermore, a plurality of the wedge-shaped protrusion units form a planar array on the channel wall, and the center spacing between the front and rear adjacent wedge-shaped protrusion units is 1.0-2.0 times the length of the wedge-shaped protrusion unit's wall surface shape along the fluid flow direction.

[0016] Preferably, the protrusion height of the wedge-shaped protrusion unit is 0.02-0.2 times the length of the wall-adhering surface pattern of the wedge-shaped protrusion unit along the flow direction.

[0017] Preferably, the protrusion height of the wedge-shaped protrusion unit is less than 0.5 mm.

[0018] Preferably, the length of the wedge-shaped protrusion unit along the fluid flow direction is 0.5-5.0 mm, and the width along the circumferential direction of the flow channel wall is 0.1-1.0 mm.

[0019] When the wedge-shaped protrusions are too large, the inward convergence and rotation of the fluid from the previous wedge-shaped protrusion cannot continue to the next adjacent wedge-shaped protrusion, making it impossible to maintain a stable vortex to achieve anti-viscosity and drag reduction. This results in an excessively large fluid boundary layer and increased resistance. Similarly, when the spacing between adjacent wedge-shaped protrusions is too large, it is impossible to maintain a stable fluid vortex to flush away heavier impurities. The wedge-shaped protrusions cannot be used to adjust the flow field distribution and reduce the thickness of the turbulent layer of easily settling fluids, making it difficult to promptly flush away dense impurities. Setting an appropriate angle between the main inclined surface and the channel wall is also beneficial for maintaining a stable fluid vortex.

[0020] Furthermore, the waveform of the corrugated protrusion unit is any one of C-shape, U-shape, S-shape, sawtooth shape, sine waveform or attenuated waveform or a combination of several of them.

[0021] Furthermore, the wave path of the corrugated protrusion unit is 0.5-100 wavelengths.

[0022] Furthermore, the height of the corrugated protrusion unit is 0.1-10 times the wavelength of the corrugated protrusion unit.

[0023] Preferably, one or more of the corrugated protrusion units form the corrugated protrusion structure that is arranged horizontally, vertically or staggered at an oblique angle.

[0024] Preferably, the interval between adjacent corrugated protrusion units is 0.1-2 times the protrusion height of the corrugated protrusion units, and the sizes are all in micron order.

[0025] Furthermore, the hydrophobic super-slip coating is a biocompatible hydrophobic flexible polymer molecular brush coating with a thickness of 5-100 nm.

[0026] Preferably, the hydrophobic flexible polymer is selected from any one of polydimethylsiloxane, perfluoropolyether, polyisobutylene and their derivatives.

[0027] The high flexibility and low chemical bond rotation energy of the hydrophobic flexible polymer molecular chain maintain the ultra-slip properties of the surface (ultra-low dynamic contact hysteresis angle CAH or Δθ < 5°) and give the surface good air-philic, oleophilic and hydrophobic properties.

[0028] The present application also provides an ultra-slip anti-stick urinary catheter with a bionic drag reduction structure, which adopts the above-mentioned bionic drag reduction structure. The ultra-slip anti-stick urinary catheter with a bionic drag reduction structure includes:

[0029] Catheter body;

[0030] The wedge-shaped protrusion structure includes a plurality of wedge-shaped protrusion units arranged in an array and attached to the inner wall surface of the catheter body, each of the wedge-shaped protrusion units includes one or more main inclined surfaces inclined to the inner wall surface of the catheter body, and the main inclined surfaces face the flow direction of urine;

[0031] A corrugated protrusion structure comprising a plurality of corrugated protrusion units arranged in an array on the main inclined surface, wherein the sizes of the corrugated protrusion units and the wedge-shaped protrusion units are both in the micron order;

[0032] The hydrophobic super-slip coating is arranged on the inner wall surface of the catheter body.

[0033] Preferably, the main body material of the urinary catheter is any one of latex, rubber, polyvinyl chloride and polyurethane or a combination of several of them.

[0034] Preferably, the ultra-slip anti-stick urinary catheter with a bionic drag-reducing structure further comprises an anti-slip balloon, and the base material of the anti-slip balloon is selected from any one of elastic latex, rubber, and polyurethane materials.

[0035] Preferably, before inserting the catheter into the urethra, a lubricant is applied to the outside of the catheter. The lubricant is any one or more of silicone lubricants, gels, water-based lubricants and polyvinyl alcohol lubricants. The selected lubricant does not swell with the catheter body and the anti-fall-off balloon.

[0036] In summary, this application includes at least one of the following beneficial technical effects:

[0037] The present application sets up a micron-scale bionic anti-adhesion and drag reduction structure on the inner wall of the catheter, fully imitating the surface characteristics of animals and plants such as silver carp and kelp that swing with low resistance in seawater and are not easily adhered to pollutants, and imitates a multi-level bionic anti-adhesion and drag reduction structure that combines the structure and arrangement of silver carp scales, the corrugated structure of the kelp skirt, and the anti-adhesion and super-slip flexible coating on its surface.

[0038] 1. The bionic drag-reducing structure on the inner wall of the catheter alters the urine flow field characteristics. Fluid vortices are generated by the grooves between adjacent wedge-shaped protrusions to propel the flow. The secondary corrugated protrusion structure increases the roughness of the main inclined surface of the wedge-shaped protrusion. Combined with the hydrophobic catheter material, it enhances the resistance-reducing and viscosity-reducing properties, promptly flushing away settled impurities and viscous fluids, delaying the formation of a turbulent layer within the catheter and reducing direct contact and adhesion between the fluid and impurities and the flow channel wall. This reduces frictional resistance between the fluid and the wall, accelerating the low-resistance flow of urine through the catheter.

[0039] 2. The bionic drag-reducing structure is combined with a hydrophobic polymer super-slippery coating. The multi-level bionic drag-reducing structure synergistically exerts hydrophobic, anti-stick, and super-slip effects, effectively preventing the adhesion and deposition of urine, blood, and stones. It also prevents urine residue, urine scaling and stones, bacterial adhesion, and biofilm formation, reducing catheter blockage and even infection, effectively extending the life of the catheter and increasing the safety and convenience of long-term indwelling catheterization.

[0040] 3. The nano-scale hydrophobic polymer super-slip coating on the outer wall of the catheter reduces the patient's discomfort during insertion and removal of the catheter and prevents friction damage to the urethral mucosal tissue by enhancing the adhesion of the lubricant. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 The present invention is a schematic diagram mainly used to illustrate the arrangement of wedge-shaped protrusion units on the flow channel wall, wherein (a)-(c) are schematic diagrams of wedge-shaped protrusion units with triangular, quadrilateral, and pentagonal wall surfaces, respectively;

[0042] Figure 2 This is a cross-sectional schematic diagram of an embodiment of the present application mainly used to illustrate the arrangement of wedge-shaped protrusion units on the flow channel wall;

[0043] Figure 3 Schematic diagrams of the structures of corrugated protrusion units of different shapes in the embodiments of the present application, wherein (a)-(f) are schematic diagrams of waveforms of C-shape, U-shape, S-shape, sawtooth shape, sinusoidal waveform or attenuated waveform, respectively;

[0044] Figure 4 Schematic diagrams of multiple horizontal arrangements of corrugated protrusion units on the main inclined surface in an embodiment of the present application, wherein (a) is one horizontal arrangement of sinusoidal protrusion units of different wave paths; (b) is a second horizontal arrangement of sinusoidal protrusion units of different wave paths; and (c) is a horizontal arrangement of sinusoidal protrusion units of the same wave path.

[0045] Figure 5 This is a schematic diagram of the overall structure of an ultra-slip anti-stick urinary catheter with a bionic drag reduction structure according to an embodiment of the present application;

[0046] Figure 6 This is a schematic diagram of the anti-viscosity and drag reduction mechanism of an ultra-slip anti-viscosity catheter with a bionic drag reduction structure according to an embodiment of the present application.

[0047] Figure numerals: 1. Catheter body; 1-1. Catheterization main tube; 1-2. Inflation / liquid channel; 1-3. Flushing and injection channel; 1-4. Catheterization port; 1-5. Inflation / liquid outlet; 1-6. Flushing and injection outlet; 2. Anti-slip balloon; 3. Diverter cone interface; 3-1. Urine outlet; 3-2. Inflation / liquid inlet; 3-3. Flushing and injection inlet; 4. Bionic anti-viscosity and drag reduction structure; 4-1. Wedge-shaped protrusion structure; 4-2. Corrugated protrusion structure; 5. Hydrophobic super-slip coating. DETAILED DESCRIPTION

[0048] The following is combined with Figure 1-6 This application is described in further detail.

[0049] The present application discloses a bionic anti-viscosity drag reduction structure for easily settling fluids, referring to Figure 1 and Figure 2 The bionic anti-viscosity drag reduction structure includes a wedge-shaped protrusion structure 4-1 and a corrugated protrusion structure 4-2. The wedge-shaped protrusion structure 4-1 includes a plurality of wedge-shaped protrusion units arranged in an array and attached to the wall of the flow channel. Each wedge-shaped protrusion unit includes one or more main inclined surfaces inclined to the wall of the flow channel and a wall-attached surface attached to the wall of the flow channel. The main inclined surface faces the flow direction of the fluid. Figure 2 In the direction of fluid flow, multiple wedge-shaped protrusion units are arranged in a fish-scale pattern with the front lower and the back higher, and grooves are formed between the adjacent wedge-shaped protrusion units.

[0050] Reference Figure 1 The wall-adhering surface is a polygon, which can be any one or a combination of polygons such as a triangle, a quadrilateral, a pentagon, etc. The wedge-shaped protrusion unit can be a polygonal pyramid or a polygonal prism truncated along the vertex.

[0051] Taking a tetrahedral wedge-shaped protrusion unit design as an example, one side of the tetrahedral pyramid is the wall-adhering surface, and the side opposite to the wall-adhering surface is the main inclined surface. The cross-section of the tetrahedral pyramid along the direction parallel to the flow channel is a triangle with an inclination angle of 5°. The height of the wedge-shaped protrusion unit is 0.4 mm, the length of the wedge-shaped protrusion unit along the flow direction is 4 mm, and the width is 0.9 mm. The center distance between two adjacent tetrahedral pyramids is about 6 mm. They are arranged in a fish scale-like manner, with the front lower and the back higher, staggered on the inner wall of the main urinary catheter channel. The arrangement method refers to Figure 1 (a) in the.

[0052] Reference Figure 1 、 Figure 3 and Figure 4The corrugated protrusion structure 4-2 includes a plurality of corrugated protrusion units arranged on the main inclined surface. The waveform of the corrugated protrusion unit can be any one of a C-shape, a U-shape, an S-shape, a sawtooth shape, a sine waveform, or a decaying waveform, or a combination thereof. The corrugated protrusion structure can be an arrangement and combination of multiple corrugated protrusion units of different heights, wave lengths, or waveforms.

[0053] As an example, Figure 4 As shown in (a), the structural parameters of a sinusoidal corrugated protrusion unit are: wavelength 100 μm, amplitude 50 μm, and protrusion height 100 μm. The corrugated protrusion structure is composed of multiple horizontally arranged sinusoidal corrugated protrusion units with wave lengths of 200 μm, 400 μm, and 600 μm, respectively. The spacing between adjacent corrugated protrusion units is 25 μm.

[0054] The bionic anti-viscosity and drag-reducing structure also includes a hydrophobic super-slip coating coated on the wall of the flow channel, which is a biocompatible hydrophobic flexible polymer molecular brush coating with a thickness of 5-100 nm.

[0055] The embodiment of the present application discloses an ultra-slip anti-stick urinary catheter having the above-mentioned bionic anti-stick drag reduction structure. Figure 5 The ultra-slip anti-stick catheter with a bionic anti-stick drag reduction structure includes a catheter body 1, an anti-slip balloon 2 and a diversion cone interface 3.

[0056] Reference Figure 5 The urinary catheter body 1 includes a main catheter tube 1-1, flanked by flushing and injection channels 1-3 and an inflation / liquid channel 1-2. The diverter cone 3 includes a urine outlet 3-1, a flushing and injection inlet 3-3, and an inflation / liquid inlet 3-2. A urinary catheter port 1-4 is defined on the end of the main catheter tube 1-1 opposite the urine outlet 3-1; a flushing and injection outlet 1-6 is defined on the end of the flushing and injection channel 1-3 opposite the flushing and injection inlet 3-3; and an inflation / liquid outlet 1-5 is defined on the end of the inflation / liquid channel 1-2 opposite the inflation / liquid inlet 3-2.

[0057] Reference Figure 5 The anti-drop-off balloon 2 is sheathed over the catheter body 1 and located near one end of the catheter port 1-4. The inner walls of both ends of the anti-drop-off balloon 2 are fixedly connected to the outer wall of the catheter body 1, which can be bonded together to form a sealed cavity between the anti-drop-off balloon 2 and the catheter body 1. The inflation / liquid outlet 1-5 is located within the sealed cavity, so that the sealed cavity is connected to the inflation / liquid channel 1-2.

[0058] The inner wall of the main catheter tube 1-1 is provided with a bionic anti-viscosity drag reduction structure 4, which includes a wedge-shaped protrusion structure, a corrugated protrusion structure and a hydrophobic super-slippery coating 5. The hydrophobic super-slippery coating 5 is applied to the outer wall of the catheter body 1 and the inner wall of the main catheter tube 1-1.

[0059] The present application provides an ultra-slip, anti-stick urinary catheter with a biomimetic drag-reducing structure, manufactured using the following method: The catheter body 1 is manufactured using a molding process such as injection molding or 3D printing. The specific method for injection molding is as follows: a uniformly mixed silicone raw material is injected into a mold, and then an inner mold with a biomimetic anti-stick drag-reducing structure 4 is inserted for extrusion molding. The biomimetic anti-stick drag-reducing structure 4 is completely replicated, and catheter ports 1-4, inflation / liquid outlets 1-5, and flushing and injection outlets 1-6 are punched into the molded catheter body. The catheter body 1 is then smoothly bonded to an anti-dropout balloon 2 and a diverter tapered interface 3, both molded using the same method.

[0060] After the catheter is pretreated with oxygen plasma, the inner and outer surfaces are repeatedly dipped in a biocompatible hydrophobic polydimethylsiloxane solution. A high-density hydrophobic polymer molecular brush coating with a thickness of 5-100 nm is grafted onto it through covalent bonds. The high flexibility and low chemical bond rotation energy of the polydimethylsiloxane molecular chain maintain the surface's ultra-slip properties (ultra-low dynamic contact hysteresis angle CAH or Δθ < 5°) and give the surface good lipophilic and hydrophobic properties (θ 油 <90°, θ 水 >90°).

[0061] During use, a suitable amount of silicone lubricant is applied to the outer wall of the catheter, and then the catheter is inserted through the urethra, allowing the anti-loosening balloon 2 to reach the bladder. A suitable amount of air or sterile saline is injected into the anti-loosening balloon 2 through the inflation / liquid channel 1-2, causing the anti-loosening balloon 2 to inflate and become lodged in the bladder, preventing the catheter from falling out during use. Urine in the bladder enters the main catheter tube 1-1 through the catheter port 1-4 and is then discharged from the urine outlet 3-1.

[0062] The principle of reducing resistance and viscosity of the ultra-slip anti-adhesive catheter with a bionic drag-reducing structure provided by this application is as follows: Figure 6 As shown, the details are as follows:

[0063] Grooves are formed between the micron-sized wedge-shaped protrusions, which are low in front and high in the back. When the fluid flows through the tail of the wedge-shaped protrusion, the fluid swirls to generate vortices, causing the part of the fluid near the wedge-shaped protrusion to generate a non-zero initial velocity, promptly washing away the settled impurities and viscous fluid, and reducing the viscous resistance inside the fluid. At the same time, the wedge-shaped protrusions, which are low in front and high in the back, keep the fluid at a high contact angle front. The micron-sized corrugated protrusion structure increases the roughness of the main inclined surface of the wedge-shaped protrusion. Combined with the hydrophobic coating, it further enhances the super-slip anti-stick properties, reduces the thickness of the fluid boundary layer, and reduces the direct contact and adhesion of the fluid and impurities with the channel wall, thereby reducing the frictional resistance between the fluid and the wall. This not only reduces the residual, adhesion or backflow of the fluid on the channel wall, achieving anti-stick drag reduction when the fluid and impurities contact the channel wall, but also reduces viscous friction, thereby reducing the energy loss of the fluid vortex, which is conducive to maintaining a stable fluid vortex and further enhancing the anti-stick effect.

[0064] In this way, urine residue, urine scale and stones, bacterial adhesion and biofilm formation can be effectively prevented, catheter blockage and even infection can be reduced, and the service life of the catheter can be effectively extended.

[0065] The nano-scale hydrophobic and super-slip coating on the outer wall of the catheter can enhance the adhesion of the lubricant, reduce the patient's discomfort when inserting and removing the catheter, and prevent friction damage to the urethral mucosal tissue.

[0066] It should be noted that the bionic anti-viscosity and drag reduction structure provided in this application can be used not only for urinary catheters, but also for other medical catheters, such as blood transfusion tubes, infusion tubes, etc., to achieve the effect of anti-viscosity and drag reduction.

[0067] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A bionic anti-viscosity drag reduction structure for easily settling fluids, characterized by: include: The wedge-shaped protrusion structure includes a plurality of wedge-shaped protrusion units arranged in an array and attached to the wall surface of the flow channel, each of the wedge-shaped protrusion units includes one or more main inclined surfaces inclined to the wall surface of the flow channel, and the main inclined surfaces face the flow direction of the fluid; A corrugated protrusion structure comprising a plurality of corrugated protrusion units arranged in an array on the main inclined surface, wherein the sizes of the corrugated protrusion units and the wedge-shaped protrusion units are both in the micron order; A hydrophobic super-slip coating is provided on the wall surface of the flow channel.

2. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 1, characterized in that: The angle between the main inclined surface and the flow channel wall is less than 10°.

3. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 1, characterized in that: The wedge-shaped protrusion unit further includes a wall-adhering surface that adheres to the wall of the flow channel. The shape of the wall-adhering surface includes one or a combination of polygonal, circular, elliptical or fan-shaped.

4. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 3, characterized in that: A plurality of the wedge-shaped protrusion units form a planar array on the wall surface of the flow channel, and the arrangement of the array includes any one of square, rhombus, hexagonal and irregular arrays or a combination of several of them.

5. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 3, characterized in that: The center distance between the front and rear adjacent wedge-shaped protrusion units is 1.0-2.0 times the length of the wall-adhering surface of the wedge-shaped protrusion unit along the fluid flow direction.

6. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 1, characterized in that: The waveform of the corrugated protrusion unit includes any one of a C-shape, a U-shape, an S-shape, a sawtooth shape, a sine waveform or an attenuated waveform or a combination of several of them.

7. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 6, characterized in that: The wave path of the corrugated protrusion unit is 0.5-100 wavelengths.

8. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 7, characterized in that: The height of the corrugated protrusion unit is 0.1-10 times the wavelength of the corrugated protrusion unit.

9. The bionic anti-viscosity drag reduction structure for easily settling fluids according to claim 1, characterized in that: The hydrophobic super-slip coating is a biocompatible hydrophobic flexible polymer molecular brush coating with a thickness of 5-100 nm.

10. An ultra-slip anti-viscosity urinary catheter with a bionic drag-reducing structure, employing the bionic anti-viscosity drag-reducing structure for easily settling fluids according to any one of claims 1 to 9, characterized in that: include: Catheter body; The wedge-shaped protrusion structure includes a plurality of wedge-shaped protrusion units arranged in an array and attached to the inner wall surface of the catheter body, each of the wedge-shaped protrusion units includes one or more main inclined surfaces inclined to the inner wall surface of the catheter body, and the main inclined surfaces face the flow direction of urine; A corrugated protrusion structure comprising a plurality of corrugated protrusion units arranged in an array on the main inclined surface, wherein the sizes of the corrugated protrusion units and the wedge-shaped protrusion units are both in the micron order; The hydrophobic super-slip coating is arranged on the inner wall surface of the catheter body.

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