Porous support particle, functional component supporting particle, and method for producing porous support particle

Abstract

Porous support particles containing a water-soluble polymer having a helical structure in glucose units and having a BET specific surface area of 1 m2 / g or more. The water-soluble polymer is preferably a water-soluble polysaccharide. It is preferable that the water-soluble polysaccharide is one or more substances selected from the group consisting of dextrin, glucan, agarose, and pullulan.

Description

Technical Field

[0001] The invention relates to porous carrier particles, functional component-carrying particles and a method for producing the porous carrier particles. This application claims priority based on Japanese Patent Application No. 2022-122676 filed in Japan on August 1, 2022, and the contents are incorporated herein by reference. Background Art

[0002] Methods for administering functional ingredients such as pharmaceutical active ingredients into the body include topical administration, enteral administration, and parenteral administration. The administered functional ingredients need to be transported from the site where they are introduced into the body to the target site where their functions are expressed. In the case of oral administration, which is one of enteral administrations, the functional ingredient is absorbed by the small intestine through the mouth and stomach. Therefore, the functional ingredient needs to be transported to the small intestine.

[0003] In order to deliver functional components to target sites in the body, a structure in which the functional components are supported on a carrier called a carrier is useful. For example, the carrier is required to have a larger capacity of functional components with a smaller particle size. As such a material, porous inorganic materials are being studied.

[0004] For example, Patent Document 1 discloses a crystalline mesoporous silica material having a zeolite-type microporous skeleton (explicitly indicated as a nano-sized structural unit) that does not produce Bragg diffraction in X-ray diffraction and the use of the material for delivering a drug. Patent Document 1 discloses that when the zeolite material is used, the release rate of the drug is less than 80%. Prior art literature Patent Literature

[0005] Patent Document 1: Japanese Patent Application No. 2007-523817 Summary of the invention Problems to be solved by the invention

[0006] Porous materials formed of inorganic compounds tend to increase their specific surface area. On the other hand, inorganic compounds are water-insoluble and cannot be dissolved in the body. In this case, there is a problem that the functional components carried by the carrier are not fully released and the desired dosage cannot be administered into the body.

[0007] The present invention has been made in view of the above circumstances, and an object of the present invention is to provide water-soluble porous carrier particles capable of supporting functional components and having a high BET specific surface area. Solutions for solving problems

[0008] The present invention includes the following [1] to [7]. [1] A porous carrier particle, wherein the porous carrier particle contains a water-soluble polymer having a helical structure with glucose as a unit and a BET specific surface area of ​​1 m 2 / g or above. [2] The porous carrier particle according to [1], wherein the water-soluble polymer is a water-soluble polysaccharide. [3] The porous carrier particle according to [1] or [2], wherein the water-soluble polysaccharide is one or more selected from the group consisting of dextrin, dextran, agarose, and pullulan. [4] The porous support particle according to any one of [1] to [3], wherein the porous support particle is spherical. [5] A functional component-carrying particle, wherein the functional component-carrying particle is obtained by causing the porous carrier particle according to any one of [1] to [4] to carry a functional component. [6] The functional ingredient-carrying particles according to [5], wherein the functional ingredient is a pharmaceutical ingredient. [7] A method for producing porous carrier particles having a BET specific surface area of ​​1 m 2 / g or more water-soluble porous carrier particles, wherein the manufacturing method comprises: a step of spray-drying a solution containing a water-soluble polymer having a helical structure with glucose as a unit to obtain precursor particles; and a step of removing liquid from the mixture after mixing an organic solvent into the precursor particles to obtain a mixture. Effects of the Invention

[0009] According to the present invention, it is possible to provide water-soluble porous carrier particles that can support functional components and have a high BET specific surface area. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 is an electron microscope photograph of the porous support particles produced in Example 1. Figure 2 is an electron microscope photograph of the porous support particles produced in Example 2. DETAILED DESCRIPTION

[0011] <Porous Carrier Particles> The porous carrier particles of the present invention contain water-soluble polymers and are water-soluble. Hereinafter, the porous carrier particles of the present invention are sometimes referred to as "carrier particles". Water-soluble carrier particles completely dissolve in the body. Therefore, both the carried functional components and the carrier particles completely dissolve in the body, and the functional components can be completely released. In addition, by being porous, the contact area with the surrounding liquid medium becomes larger, so that rapid solubility can also be exerted.

[0012] As water-soluble porous particles, for example, the BET specific surface area of ​​the known water-soluble porous particles described in Japanese Patent Application Laid-Open No. 4-335870 is 0.2 m 2 / g or less, and the specific surface area is very small.

[0013] In contrast, the carrier particles of the present invention have a higher specific surface area than conventional water-soluble porous particles, and thus can carry a larger amount of functional components than conventional water-soluble porous particles.

[0014] The term "water-soluble" means that the compound has a solubility of 1 g or more in 100 g of distilled water at 25°C and 1 atmosphere.

[0015] “Porous” means having many pores and a BET specific surface area of ​​1 m 2 / g or above.

[0016] The carrier particles are preferably substantially composed of a water-soluble polymer. Here, “substantially composed of a water-soluble polymer” means a form in which the carrier particles consist only of a water-soluble polymer and contain other components to an extent that the function of the carrier as a functional component is not reduced.

[0017] “Does not reduce the function of the carrier as a functional component, etc.” means that the amount of functional components carried is not reduced, and when used as a pharmaceutical, it can be administered into a living body, etc. Specifically, it means that the content ratio of other components relative to the entire carrier particle is 1% by mass or less, preferably 0.1% by mass or less. Hereinafter, each component will be described.

[0018] Water-soluble polymers The water-soluble polymer in this embodiment has a helical structure with glucose as a unit. Whether or not the carrier particles contain a water-soluble polymer having a helical structure with glucose as a unit can be confirmed by the following method.

[0019] According to the confirmation method of dextrin described in the 18th edition of the Japanese Pharmacopoeia, page 1150, 100 mL of water is added to 0.1 g of the carrier particles, and 1 drop of iodine test solution is added. After the addition of iodine test solution, when the liquid turns light reddish brown or light reddish purple, it is judged that the carrier particles contain a water-soluble polymer having a helical structure with glucose as the unit.

[0020] From the viewpoint of safe administration when the carrier particles are used for pharmaceutical applications, the water-soluble polymer used in the present embodiment is preferably a natural polymer. Specifically, a water-soluble polysaccharide can be used as the natural polymer.

[0021] The water-soluble polysaccharide used in the present embodiment is a water-soluble polymer having a helical structure in which glucose is polymerized in a chain. The water-soluble polysaccharide preferably has a three-dimensional network structure branched into a plurality of branches.

[0022] The water-soluble polysaccharide having a three-dimensional network structure is preferably at least one selected from the group consisting of dextrin, dextran, agarose, and pullulan, and among them, dextrin is more preferred.

[0023] In addition, from the viewpoint of safe administration, the water-soluble polymer preferably does not contain any metal element. In addition, the entire carrier particle preferably does not contain any metal element.

[0024] The method for producing the carrier particles will be described in detail later, and a solution containing a water-soluble polymer is spray-dried to obtain precursor particles, and the obtained precursor particles are mixed with an organic solvent to obtain a mixture. The carrier particles are obtained by removing the liquid from the obtained mixture.

[0025] When the water-soluble polymer has a three-dimensional network structure, a portion of the glucose chains (such as maltose, maltotriose, etc.) contained in the three-dimensional network structure (precursor particles) are extracted and removed by an organic solvent, and the site where the extract once existed becomes a micropore, forming a carrier particle.

[0026] 《Any ingredient》 The carrier particles preferably do not contain an organic acid described below, but may contain a small amount of the organic acid. “The carrier particles do not contain an organic acid” means that when the amount of the organic acid contained in the carrier particles is measured, the measured amount of the organic acid is below the detection limit.

[0027] In the manufacturing process of the carrier particles, the organic acid may or may not be used, but if used, it is eventually removed. Depending on the removal method, the organic acid may slightly remain in the carrier particles. In this case, the amount of the organic acid in the carrier particles measured by the following method is preferably 1% or less.

[0028] [Method for determining organic acid in carrier particles] The organic acid can be detected by dissolving the carrier particles in an aqueous phosphoric acid solution and then analyzing the solution using high performance liquid chromatography (HPLC).

[0029] 《BET specific surface area》 The BET specific surface area of ​​the carrier particles is 1 m 2 / g or more, preferably 40m 2 / g or more, more preferably 50m 2 / g or more, particularly preferably 100m 2 / g or more, more preferably 150m 2The upper limit of the BET specific surface area is, for example, 1000 m 2 / g or less, 900m 2 / g or less, 800m 2 / g or less. The above upper limit and lower limit of the BET specific surface area may be combined arbitrarily. 2 / g to 1000m 2 / g, 40m 2 / g to 1000m 2 / g, 50m 2 / g to 1000m 2 / g、100m 2 / g to 900m 2 / g, and 150m 2 / g to 800m 2 / g.

[0030] [Measurement method of BET specific surface area] The BET specific surface area of ​​the carrier particles is measured by the nitrogen adsorption BET (Brunauer, Emmett, Teller) method using a specific surface area measuring device. As the specific surface area measuring device, for example, a specific surface area measuring device manufactured by Mountech (device name: Macsorb) can be used.

[0031] "shape" The shape of the carrier particles is not particularly limited, but is preferably spherical. The particle shape can be confirmed by static image analysis. Still image analysis can be performed using a still image automatic analysis device. As a still image automatic analysis device, for example, MORPHOLOGI4 manufactured by Malvern Panalytical can be used.

[0032] Particle size The average particle size of the carrier particles can be set to, for example, a range of 5 μm to 1000 μm, 10 μm to 800 μm, 20 μm to 600 μm, 30 μm to 500 μm, 40 μm to 400 μm, or 50 μm to 300 μm.

[0033] [Method for measuring average particle size] The average particle size of the carrier particles can be measured by laser diffraction or laser scattering.

[0034] Hereinafter, the method for producing the carrier particles of the present invention will be described.

[0035] <Method for producing carrier particles> The method for producing carrier particles will be described by taking the case of producing spherical carrier particles as an example. The method for producing the carrier particles may include the following production method 1 or production method 2.

[0036] 《Manufacturing method 1》 The method 1 for producing carrier particles includes a step of obtaining precursor particles using a water-soluble polymer (production raw material) and a step of obtaining carrier particles.

[0037] [Step of Obtaining Precursor Particles] First, a water-soluble polymer as a raw material is dissolved in water to obtain an aqueous solution. Then, the obtained aqueous solution is spray-dried to obtain precursor particles. Spray drying can be performed using a known spray drying device. The concentration of the solid content (solute) contained in the aqueous solution is preferably in the range of 30% to 80%, and more preferably 40% to 60%.

[0038] If the concentration of the solid component in the aqueous solution is above the lower limit, a solid structured precursor particle with internal obstruction can be obtained, and more pores are formed when the liquid is removed by mixing with an organic solvent in a subsequent step. When the concentration of the solid component in the aqueous solution is below the upper limit, spray drying is easy, and the precursor particles and the carrier particles obtained in the subsequent steps are close to spherical.

[0039] An example of the spray drying conditions is a condition in which the inlet temperature is 120° C. to 160° C., the outlet temperature is 80° C. to 120° C., and the supply rate of the aqueous solution is 5 kg / hour to 25 kg / hour. The water-soluble polymer is the same as described in the above-mentioned <Porous Carrier Particles>.

[0040] [Step of Obtaining Carrier Particles] The precursor particles are mixed with an organic solvent and the liquid is removed from the mixture. As the organic solvent, a known organic solvent can be used. In the present embodiment, a hydrophilic organic solvent is preferred, and as the hydrophilic organic solvent, for example, ethanol and methanol are preferred.

[0041] The precursor particles can be mixed with the organic solvent by suspending the precursor particles in the heated organic solvent and keeping the suspension for a predetermined time or longer. The heating temperature and heating time can be appropriately adjusted according to the organic solvent used, for example, keeping the suspension at 0°C to 70°C for 10 minutes or longer and 120 minutes or shorter.

[0042] Next, by removing the liquid from the mixture, a portion of the glucose chains constituting the water-soluble polymer (manufacturing raw material) (for example, sugars such as maltose and maltotriose having glucose as a basic unit) are removed from the precursor particles, and the removal traces become pores to obtain carrier particles.

[0043] The liquid removed here is an organic solvent containing a part of the glucose chain constituting the water-soluble polymer (production raw material).

[0044] In the production method 1, examples of the water-soluble polymer used as a production raw material include dextrin. The saccharification rate of starch of the dextrin used as the production raw material is not particularly limited, and may be dextrin having a DE value of 10 or less, maltodextrin having a DE value of more than 10 and less than 20, or dextrin having a DE value of more than 20.

[0045] As a method for removing the liquid from the mixture, a known method can be used, such as filtration and decantation. In addition, by repeatedly mixing the organic solvent in the particles obtained by removing the liquid and removing the liquid from the mixture, the specific surface area of ​​the carrier particles obtained can be increased.

[0046] Among them, when dextrin having a high content of maltose or maltotriose is used as the dextrin used as the production raw material, traces of the removal of maltose or maltotriose become pores, and carrier particles with a high BET specific surface area are easily obtained.

[0047] Manufacturing Method 2 The method 2 for producing carrier particles includes a step of obtaining precursor particles of particles of a water-soluble polymer (production raw material) and a step of obtaining carrier particles. The difference from the above-mentioned production method 1 is that a template (mold agent) is added to the aqueous solution in the step of obtaining precursor particles. As the template, an organic acid, sugar or sugar alcohol can be used.

[0048] (Organic Acid) The organic acid is preferably citric acid, malic acid, tartaric acid, succinic acid, or adipic acid, and more preferably citric acid, malic acid, or tartaric acid.

[0049] (Sugar or sugar alcohol) The sugar is, for example, a monosaccharide or a disaccharide. As monosaccharides, glucose, fructose and galactose can be used. As the disaccharide, sucrose, lactose, maltose, trehalose, and cellobiose can be used, among which maltose or trehalose is preferred, and trehalose is particularly preferred.

[0050] Examples of sugar alcohol include mannitol, erythritol, and xylitol. Production method 2 is preferably used when dextrin with a low content of maltose or maltotriose is used as a production raw material. In this production method 2, traces of the template added instead of maltose or maltotriose in the dextrin used as the production raw material are removed to form pores, making it easy to obtain carrier particles with a high BET specific surface area.

[0051] <Functional ingredient-carrying particles> The present invention provides functional component-carrying particles in which the functional component is carried on the above-mentioned carrier particles. Examples of the functional ingredients include pharmaceutical active ingredients, pharmaceutical additives, functional food ingredients, pigments, and flavorings.

[0052] The carrier particles of the present embodiment have rapid solubility and can release all the supported components, and therefore can be suitably used as a carrier of active ingredients of pharmaceuticals.

[0053] As the pharmaceutical active ingredient to be carried, for example, one or more components selected from antipyretic, analgesic and anti-inflammatory drugs, psychotropic drugs, antianxiety drugs, antidepressants, sleep sedatives, tranquilizers, central nervous system drugs, brain metabolism improving drugs, brain circulation improving drugs, antiepileptic drugs, sympathetic nerve stimulants, gastrointestinal drugs, antacids, antiulcer drugs, antitussive expectorants, antiemetics, respiratory stimulants, bronchodilators, allergy drugs, dental and oral drugs, antihistamines, cardiotonic drugs, arrhythmia drugs, diuretics, hypotensive drugs, vasoconstrictors, coronary vasodilators, peripheral vasodilators, hyperlipidemia drugs, choleretics, antibiotics, chemotherapeutic agents, diabetes drugs, osteoporosis drugs, antirheumatic drugs, analgesics, hormone agents, alkaloid anesthetics, sulfonamides, gout therapeutic agents, blood coagulation inhibitors, anti-malignant tumor agents, nourishing and strengthening health care drugs, etc. can be used.

[0054] Examples of functional food ingredients include vitamins such as vitamin A, vitamin D, and vitamin E, and higher unsaturated fatty acids such as DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), and hepatic oil.

[0055] The method for making the carrier particles support the functional component is preferably to impregnate the carrier particles with the desired functional component. As such a method, for example, the method described in US 10004682 B2 can be used.

[0056] In addition, examples of methods for making carrier particles support functional components include the following methods. First, the functional component is dissolved in an organic solvent to obtain a functional component solution. The organic solvent is, for example, ethanol. At this time, in order to increase the solubility of the functional component, a small amount of water (about 1% relative to the total amount of the functional component solution) can be added to the organic solvent. The carrier particles are then mixed with the functional ingredient solution. Examples of a method for mixing the carrier particles and the functional component solution include a method of dripping or spraying the obtained functional component solution onto the carrier particles. After a predetermined amount of the functional component solution is mixed with the carrier particles, the mixture is dried under reduced pressure at a temperature of 20° C. to 60° C., thereby obtaining carrier particles carrying the functional component.

[0057] <Powdered base material of oily substance> The carrier particles of this embodiment have a high affinity for oily substances and can be suitably used as a base material for powdering oily substances.

[0058] <Catalyst or catalyst carrier> The carrier particles of this embodiment can be used as a catalyst or as a catalyst carrier. Examples of the supported catalyst include catalysts containing platinum, palladium, or iridium as a main component, and titanium oxide. Example

[0059] Next, the present invention will be described in more detail by way of examples.

[0060] <Example 1> [Step of Obtaining Precursor Particles] 2.0 kg of dextrin (GLUCIDEX IT47) was dissolved in 3.0 kg of water heated to 70°C to obtain an aqueous solution 1. The DE value of the dextrin used was 47. The aqueous solution 1 was sprayed using a spray dryer under the following conditions to obtain precursor particles 1. (Spray conditions) Inlet temperature: 140℃ Outlet temperature: 96℃~100℃ Disc speed: 5000rpm Aqueous solution supply rate: Liquid rate 7kg / hour

[0061] [Step of Obtaining Carrier Particles] 60 ml of anhydrous ethanol was added to 3 g of the precursor particles, and the mixture was shaken and mixed in a water bath at 50°C for 10 minutes. After the shaking was completed, the mixture was allowed to stand for 2 minutes, and the supernatant was removed by decantation. 60 ml of anhydrous ethanol was added again, and the same shaking and decantation were performed as above, and this was repeated 10 times in total from the beginning. After the final decantation, the mixture was dried at 40°C and -0.1 MPa overnight, and passed through an 83M sieve to obtain carrier particles 1.

[0062] The carrier particles 1 satisfy the conditions of water solubility and porosity defined in this specification.

[0063] The electron microscope photo of the carrier particle 1 (magnification 2000 times) is as follows Figure 1 As shown. Figure 1 As shown, the carrier particles 1 are spherical.

[0064] The specific surface area of ​​the carrier particles 1 measured by the above-mentioned [BET specific surface area measurement method] is 174 m 2 / g.

[0065] The pore diameter of carrier particle 1 is 11.9 nm and the pore volume is 0.52 cm 3 / g.

[0066] <Example 2> [Step of Obtaining Precursor Particles] 9 kg of water (water temperature 70° C.), 12.6 kg of trehalose (Trehalose P, manufactured by Hayashibara Co., Ltd.), 6.3 kg of dextrin (SANDEK#300, manufactured by Sanwa Starch Industries, Ltd.), and 2.1 kg of anhydrous citric acid were mixed to obtain an aqueous solution 2 having a solid content concentration of 70%. The dextrin used had a DE of 27. The aqueous solution 2 obtained under the following conditions was sprayed with a spray dryer to obtain precursor particles 2. (Spray conditions) Inlet temperature: 140℃ Outlet temperature: 101℃ Disc speed: 8000rpm Supply rate of aqueous solution: 23kg / hour

[0067] [Step of Obtaining Carrier Particles] 300 ml of anhydrous ethanol was added to 15 g of the obtained precursor particles, and the mixture was shaken and mixed in a water bath at 50° C. for 15 minutes. After the shaking was completed, the mixture was allowed to stand for 2 minutes, and the supernatant was removed by decantation. 300 ml of anhydrous ethanol was added again, and the same shaking and decantation as above were repeated 10 times in total from the beginning. After the final decantation, the mixture was dried at 40° C. and -0.1 MPa for 2 hours, and passed through an 83M sieve to obtain carrier particles 2.

[0068] The carrier particles 2 satisfy the conditions of water solubility and porosity defined in this specification.

[0069] The electron microscope photo of the carrier particle 2 (magnification 2000 times) is as follows Figure 2 As shown. Figure 2 As shown, the carrier particles 2 are spherical.

[0070] The specific surface area of ​​the carrier particles 2 measured by the above-mentioned [BET specific surface area measurement method] is 144 m 2 / g.

[0071] The pore diameter of carrier particle 2 is 13.8 and the pore volume is 0.50 cm 3 / g.

[0072] <Example 3> [Step of Obtaining Precursor Particles] 400 g of water (water temperature 70° C.), 390 g of trehalose (Trehalose P, manufactured by Hayashibara Co., Ltd.), 180 g of dextrin (Palindex #3, manufactured by Matsutani Chemical Industry Co., Ltd.), and 30 g of anhydrous citric acid were mixed to obtain an aqueous solution 3 having a solid content concentration of 60%. The dextrin used had a DE of 25. The aqueous solution 3 obtained under the following conditions was sprayed with a spray dryer to obtain precursor particles 3. (Spray conditions) Inlet temperature: 140℃ Outlet temperature: 98℃ Disc speed: 10000rpm Aqueous solution supply rate: 100ml / min

[0073] [Step of Obtaining Carrier Particles] Add 20 ml of anhydrous ethanol to 5 g of the obtained precursor particles, and shake and mix in a water bath at 60°C for 30 minutes to 1 hour. After the shaking is completed, let it stand and remove the supernatant by decantation. Add 20 ml of anhydrous ethanol again, shake and decant in the same way as above, and repeat it 11 times in total from the beginning. After the final decantation, add 20 ml of anhydrous ethanol, mix gently and let it stand, then decant and remove the supernatant. Dry at 50°C and -0.08 MPa to obtain carrier particles 3.

[0074] The carrier particles 3 satisfy the conditions of water solubility and porosity defined in this specification.

[0075] The specific surface area of ​​the carrier particles 3 measured by the above-mentioned [BET specific surface area measurement method] is 7.64 m 2 / g.

[0076] <Example 4> [Step of Obtaining Precursor Particles] 1000 g of water (water temperature 70° C.), 1500 g of trehalose (Trehalose P, manufactured by Hayashibara Co., Ltd.), 600 g of dextrin (GLUCIDEX IT29, manufactured by ROQUETTE), and 233 g of anhydrous citric acid were mixed to obtain an aqueous solution 4 having a solid content concentration of 70%. The dextrin used had a DE of 29. The aqueous solution 4 obtained under the following conditions was sprayed with a spray dryer to obtain precursor particles 4. (Spray conditions) Inlet temperature: 140℃ Outlet temperature: 99℃-100℃ Disc speed: 13000rpm Aqueous solution supply rate: 100ml / min

[0077] [Step of Obtaining Carrier Particles] 120 ml of anhydrous ethanol was added to 6 g of the obtained precursor particles, and the mixture was shaken in a water bath at 40°C for 10 minutes. After the shaking was completed, the mixture was allowed to stand for 5 minutes, and the supernatant was removed by decantation. 120 ml of anhydrous ethanol was added again, and the mixture was shaken and decanted in the same manner as above, and this was repeated 10 times in total from the beginning. After the final decantation, 120 ml of anhydrous ethanol was added, the mixture was gently mixed, and the mixture was allowed to stand for 5 minutes, and then the supernatant was removed by decantation. The mixture was dried at 50°C and -0.08 MPa to obtain carrier particles 4.

[0078] The carrier particles 4 satisfy the conditions of water solubility and porosity defined in this specification.

[0079] The specific surface area of ​​the carrier particles 4 measured by the above-mentioned [BET specific surface area measurement method] is 67.29 m 2 / g.

[0080] <Example 5> Carrier particles 5 were obtained by the same method as in Example 4 except that dextrin was changed to dextrin (GLUCIDEX IT33, ROQUETTE).

[0081] The carrier particles 5 satisfy the conditions of water solubility and porosity defined in this specification.

[0082] The specific surface area of ​​the carrier particles 5 measured by the above-mentioned [BET specific surface area measurement method] is 82.17 m 2 / g.

[0083] The carrier particles of Examples 1 to 5 are porous and have a high specific surface area, so the amount of functional components carried can be increased. In addition, the porous carrier particles of Examples 1 to 5 are water-soluble and therefore completely dissolved in the body. Therefore, both the carried functional components and the carrier particles are completely dissolved in the body, and the functional components can be completely released.

Claims

1. A porous carrier particle, wherein: The porous carrier particles contain a water-soluble polymer having a helical structure with glucose as a unit, and the BET specific surface area is 1 m 2 / g or above.

2. The porous carrier particle according to claim 1, wherein The water-soluble polymer is a water-soluble polysaccharide.

3. The porous carrier particle according to claim 2, wherein: The water-soluble polysaccharide is one or more selected from the group consisting of dextrin, dextran, agarose, and pullulan.

4. The porous carrier particle according to claim 1 or 2, wherein: The porous carrier particles are spherical.

5. A functional ingredient-carrying particle, wherein: The functional component-carrying particles are obtained by allowing the porous carrier particles according to claim 1 or 2 to carry the functional component.

6. The functional ingredient-carrying particles according to claim 5, wherein The functional ingredients are medicinal ingredients.

7. A method for producing porous carrier particles, wherein the porous carrier particles have a BET specific surface area of ​​1 m 2 / g or more, among which, The manufacturing method comprises: A step of spray drying a solution containing a water-soluble polymer having a helical structure with glucose as a unit to obtain precursor particles; and A step of mixing the precursor particles and an organic solvent to obtain a mixture and then removing the liquid from the mixture.

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